SIMILAR PATTERNS OF AMINO ACIDS FOR 1ERR_A_RALA600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		5 THR A 326
ALA A 330
LEU A 331
LEU A 362
ARG A 219
 SO4  A 490 (-3.3A)
None
None
None
None
 1.24A 1errA-1c7jA:
undetectable		 1errA-1c7jA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 GLU A  49
LEU A  48
LEU A 301
ARG A 335
ILE A 290
 None
 0.97A 1errA-1cj2A:
undetectable		 1errA-1cj2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		5 ALA D 269
GLU D 272
LEU D 273
ILE D 286
LEU D 240
 None
 1.21A 1errA-1dkgD:
undetectable		 1errA-1dkgD:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		6 THR A  97
ALA A  92
GLU A  93
LEU A  91
ARG A 301
ILE A 261
 None
 1.37A 1errA-1fhuA:
undetectable		 1errA-1fhuA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw1 GLUTATHIONE
TRANSFERASE ZETA

(Homo sapiens) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		5 THR A 160
ALA A 162
ASP A 163
LEU A 166
MET A 101
 None
 1.23A 1errA-1fw1A:
undetectable		 1errA-1fw1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 THR A 179
ALA A 567
LEU A 565
TRP A 595
LEU A 574
 None
 1.06A 1errA-1g8kA:
undetectable		 1errA-1g8kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		6 ALA A 327
ASP A 328
LEU A 326
LEU A 179
ILE A 316
LEU A 335
 None
 1.47A 1errA-1hlgA:
undetectable		 1errA-1hlgA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN GAMMA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 THR C 259
ALA C 260
ASP C 261
MET C 379
ILE C 367
 None
 0.99A 1errA-1m1jC:
undetectable		 1errA-1m1jC:
17.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASP A 351
GLU A 353
LEU A 354
TRP A 383
LEU A 391
ARG A 394
 None
EST  A   1 (-2.8A)
None
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
 0.94A 1errA-1pcgA:
32.5		 1errA-1pcgA:
98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASP A 351
GLU A 353
TRP A 383
LEU A 391
ARG A 394
ILE A 424
LEU A 525
 None
EST  A   1 (-2.8A)
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.6A)
 0.82A 1errA-1pcgA:
32.5		 1errA-1pcgA:
98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 THR A 347
ALA A 350
GLU A 353
LEU A 354
TRP A 383
MET A 388
LEU A 391
ARG A 394
 None
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
None
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
 0.53A 1errA-1pcgA:
32.5		 1errA-1pcgA:
98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 THR A 347
ALA A 350
GLU A 353
TRP A 383
MET A 388
LEU A 391
ARG A 394
ILE A 424
LEU A 525
 None
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.6A)
 0.73A 1errA-1pcgA:
32.5		 1errA-1pcgA:
98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 THR A 347
ALA A 350
GLU A 353
TRP A 383
MET A 388
LEU A 391
ARG A 394
MET A 421
LEU A 525
 None
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 (-3.6A)
 0.72A 1errA-1pcgA:
32.5		 1errA-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tah LIPASE

(Burkholderia
glumae) 		no annotation 5 ALA B 246
LEU B 245
LEU B 265
ILE B 289
LEU B 292
 None
 1.22A 1errA-1tahB:
undetectable		 1errA-1tahB:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 343
LEU A 347
TRP A 376
ARG A 387
ILE A 499
 MEI  A1001 (-3.3A)
None
None
MEI  A1001 (-3.6A)
None
 1.13A 1errA-1uhlA:
22.2		 1errA-1uhlA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v76 RNASE P PROTEIN
PH1771P

(Pyrococcus
horikoshii) 		PF01868
(UPF0086) 		5 THR A 103
ALA A  99
ASP A 101
LEU A  48
ILE A  44
 None
 1.23A 1errA-1v76A:
undetectable		 1errA-1v76A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ALA A 156
ASP A 157
LEU A 160
MET A  94
ARG A  69
 None
 1.17A 1errA-1vf1A:
undetectable		 1errA-1vf1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		5 ALA A 246
LEU A 250
TRP A 279
ARG A 290
ILE A 402
 9CR  A 201 (-3.6A)
None
None
9CR  A 201 (-2.8A)
None
 1.07A 1errA-1xiuA:
22.2		 1errA-1xiuA:
29.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
LEU A 276
TRP A 305
ARG A 316
ILE A 428
 9CR  A 801 (-3.5A)
None
None
9CR  A 801 (-2.6A)
None
 1.17A 1errA-1xlsA:
22.1		 1errA-1xlsA:
31.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddw PYRIDOXINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		5 ALA A 153
TRP A 191
LEU A 120
ARG A 114
ILE A  18
 None
 1.15A 1errA-2ddwA:
undetectable		 1errA-2ddwA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyk GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1) 		5 THR A  94
ALA A  96
ASP A  97
GLU A  99
TRP A  60
 None
 1.12A 1errA-2dykA:
undetectable		 1errA-2dykA:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 272
ASP A 273
GLU A 275
LEU A 276
TRP A 305
ARG A 316
 OHT  A 500 (-3.5A)
OHT  A 500 (-3.1A)
OHT  A 500 (-2.6A)
OHT  A 500 (-4.9A)
None
OHT  A 500 (-3.8A)
 0.70A 1errA-2gpvA:
26.4		 1errA-2gpvA:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Thermotoga
maritima) 		PF01680
(SOR_SNZ) 		5 THR A 218
ALA A 220
ASP A 221
LEU A 224
LEU A 266
 None
 1.13A 1errA-2issA:
undetectable		 1errA-2issA:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASP A 351
GLU A 353
ARG A 394
ILE A 424
LEU A 525
 None
EST  A 596 (-2.7A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 (-3.6A)
 1.09A 1errA-2ocfA:
31.6		 1errA-2ocfA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 THR A 347
ALA A 350
GLU A 353
TRP A 383
MET A 388
ARG A 394
ILE A 424
LEU A 525
 None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
None
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 (-3.6A)
 0.86A 1errA-2ocfA:
31.6		 1errA-2ocfA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 THR A 347
ALA A 350
GLU A 353
TRP A 383
MET A 388
ARG A 394
MET A 421
LEU A 525
 None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
None
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 (-3.6A)
 0.89A 1errA-2ocfA:
31.6		 1errA-2ocfA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 THR A 347
ALA A 350
GLU A 353
TRP A 383
MET A 388
LEU A 391
ARG A 394
ILE A 424
 None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
 0.67A 1errA-2ocfA:
31.6		 1errA-2ocfA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 THR A 347
ALA A 350
GLU A 353
TRP A 383
MET A 388
LEU A 391
ARG A 394
MET A 421
 None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.68A 1errA-2ocfA:
31.6		 1errA-2ocfA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 THR A 347
GLU A 353
LEU A 354
TRP A 383
MET A 388
LEU A 391
ARG A 394
 None
EST  A 596 (-2.7A)
None
None
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
 0.70A 1errA-2ocfA:
31.6		 1errA-2ocfA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		5 ALA A 348
ASP A 345
MET A 355
LEU A 354
ILE A 370
 None
 1.22A 1errA-2paaA:
undetectable		 1errA-2paaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		5 THR A 351
ALA A 354
LEU A 358
LEU A 286
LEU A 328
 None
 1.20A 1errA-2q09A:
undetectable		 1errA-2q09A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 ALA A  36
TRP A  69
LEU A  77
ARG A  80
MET A 108
 1CA  A 247 (-3.6A)
None
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
 0.88A 1errA-2q3yA:
24.9		 1errA-2q3yA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis) 		PF01636
(APH) 		5 LEU A 247
MET A 141
LEU A 144
ILE A 274
LEU A 131
 None
 1.14A 1errA-2q83A:
undetectable		 1errA-2q83A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 ALA A 164
GLU A 554
LEU A  49
ARG A  47
LEU A   7
 None
 1.17A 1errA-2qxlA:
undetectable		 1errA-2qxlA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		5 THR A 211
ALA A 213
LEU A 217
LEU A 197
ILE A 353
 None
 1.21A 1errA-2r26A:
undetectable		 1errA-2r26A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT

(Bacillus
subtilis) 		PF02302
(PTS_IIB) 		5 ALA A  96
LEU A  97
LEU A  77
ILE A   6
LEU A  23
 None
 1.22A 1errA-2r48A:
undetectable		 1errA-2r48A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 THR G 279
ALA G 282
GLU G 285
ILE G 439
LEU G 303
 None
 1.05A 1errA-2uv8G:
undetectable		 1errA-2uv8G:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va1 URIDYLATE KINASE

(Ureaplasma
parvum) 		PF00696
(AA_kinase) 		5 THR A 182
ALA A 186
LEU A 187
MET A 194
ILE A 154
 None
 0.94A 1errA-2va1A:
undetectable		 1errA-2va1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqd BIOTIN CARBOXYLASE

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 THR A  28
ALA A  45
ASP A  46
MET A  40
LEU A  39
 None
 1.18A 1errA-2vqdA:
undetectable		 1errA-2vqdA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ALA A 534
LEU A 532
LEU A 543
ILE A 483
LEU A 476
 None
 1.11A 1errA-2w1zA:
undetectable		 1errA-2w1zA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w35 ENDONUCLEASE V

(Thermotoga
maritima) 		PF04493
(Endonuclease_5) 		5 THR A 210
ASP A  43
LEU A  44
LEU A 100
ILE A 132
 None
MG  A1224 (-2.5A)
None
None
None
 1.22A 1errA-2w35A:
undetectable		 1errA-2w35A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Homo sapiens) 		PF05645
(RNA_pol_Rpc82)
PF08221
(HTH_9) 		5 ALA A 431
LEU A 435
MET A 398
LEU A 399
LEU A 370
 None
 0.91A 1errA-2xubA:
undetectable		 1errA-2xubA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayr ENDOGLUCANASE

(Piromyces
rhizinflatus) 		PF00150
(Cellulase) 		5 THR A  22
ALA A  25
ASP A  24
TRP A  87
LEU A  31
 None
 1.19A 1errA-3ayrA:
undetectable		 1errA-3ayrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 THR C 259
ALA C 260
ASP C 261
MET C 379
ILE C 367
 None
 0.97A 1errA-3bvhC:
undetectable		 1errA-3bvhC:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byv RHOPTRY KINASE

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ALA A 548
LEU A 546
LEU A 404
ARG A 558
ILE A 497
 None
 1.21A 1errA-3byvA:
undetectable		 1errA-3byvA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 ALA A 272
LEU A 276
TRP A 305
ARG A 316
ILE A 428
 9CR  A7223 (-4.2A)
None
None
9CR  A7223 (-3.7A)
None
 1.03A 1errA-3dzuA:
21.9		 1errA-3dzuA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1h PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 THR A 118
ALA A 158
LEU A 156
LEU A 165
ILE A 112
 None
 1.24A 1errA-3e1hA:
undetectable		 1errA-3e1hA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE

(Neisseria
meningitidis) 		PF01225
(Mur_ligase)
PF08245
(Mur_ligase_M) 		5 THR A 154
ALA A 133
GLU A 128
LEU A 132
ILE A  20
 None
 1.16A 1errA-3eagA:
undetectable		 1errA-3eagA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fib FIBRINOGEN GAMMA
CHAIN RESIDUES

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		5 THR A 259
ALA A 260
ASP A 261
MET A 379
ILE A 367
 None
 1.02A 1errA-3fibA:
undetectable		 1errA-3fibA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		5 THR A  33
ALA A  36
ASP A  37
LEU A  40
LEU A  72
 None
 1.19A 1errA-3g87A:
undetectable		 1errA-3g87A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc2 O-SUCCINYLBENZOATE
SYNTHASE

(Salmonella
enterica) 		PF13378
(MR_MLE_C) 		5 ALA A  92
GLU A  93
LEU A  91
ARG A 301
ILE A 261
 None
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-3.2A)
None
 1.21A 1errA-3gc2A:
undetectable		 1errA-3gc2A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcg L0028 (MITOCHONDRIA
ASSOCIATED PROTEIN)

(Escherichia
coli) 		PF03278
(IpaB_EvcA) 		5 THR B 190
ALA B 193
GLU B 196
LEU B 195
LEU B  91
 None
 1.26A 1errA-3gcgB:
undetectable		 1errA-3gcgB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4r A-KINASE ANCHOR
PROTEIN 18

(Homo sapiens) 		PF10469
(AKAP7_NLS)
PF10470
(AKAP7_RIRII_bdg) 		5 THR A 150
ALA A 152
GLU A 155
LEU A 156
LEU A 140
 None
 1.25A 1errA-3j4rA:
undetectable		 1errA-3j4rA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE

(Methanocaldococcus
jannaschii) 		PF02277
(DBI_PRT) 		5 THR A  48
ALA A  51
ASP A  52
GLU A  54
LEU A  55
 None
 0.49A 1errA-3l0zA:
undetectable		 1errA-3l0zA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 ALA A 108
ASP A 111
LEU A 110
LEU A 153
LEU A 208
 None
 1.14A 1errA-3l2zA:
undetectable		 1errA-3l2zA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv9 PUTATIVE TRANSPORTER

(Clostridioides
difficile) 		PF00571
(CBS) 		5 THR A  54
GLU A  51
MET A  32
ILE A  66
LEU A 117
 None
 1.20A 1errA-3lv9A:
undetectable		 1errA-3lv9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1

(Saccharomyces
cerevisiae) 		PF01680
(SOR_SNZ) 		5 THR A 217
ALA A 219
ASP A 220
LEU A 223
LEU A 265
 None
 1.17A 1errA-3o07A:
undetectable		 1errA-3o07A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 THR A 229
LEU A 361
LEU A 139
ILE A 169
LEU A 160
 None
 1.25A 1errA-3olzA:
undetectable		 1errA-3olzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp6 CVIR TRANSCRIPTIONAL
REGULATOR

(Chromobacterium
violaceum) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		5 THR A 175
ALA A 143
LEU A 104
ILE A 185
LEU A  58
 None
 1.05A 1errA-3qp6A:
undetectable		 1errA-3qp6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp8 CVIR TRANSCRIPTIONAL
REGULATOR

(Chromobacterium
violaceum) 		PF03472
(Autoind_bind) 		5 THR A 175
ALA A 143
LEU A 104
ILE A 185
LEU A  58
 None
 1.07A 1errA-3qp8A:
undetectable		 1errA-3qp8A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 THR A  60
ALA A  58
ASP A 126
ILE A  68
LEU A 154
 None
None
VBN  A   1 (-3.7A)
None
None
 1.06A 1errA-3r5tA:
undetectable		 1errA-3r5tA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rju BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Yersinia pestis) 		PF00144
(Beta-lactamase) 		5 ALA A 165
ASP A 166
MET A  64
ILE A  57
LEU A 195
 None
 1.23A 1errA-3rjuA:
undetectable		 1errA-3rjuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s83 GGDEF FAMILY PROTEIN

(Caulobacter
vibrioides) 		PF00563
(EAL) 		5 THR A 387
ASP A 421
MET A 358
ILE A 304
LEU A 342
 None
 1.14A 1errA-3s83A:
undetectable		 1errA-3s83A:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		5 ALA A 297
GLU A 300
LEU A 298
ARG A 132
ILE A 203
 None
 1.06A 1errA-3wwxA:
undetectable		 1errA-3wwxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		5 ALA A 297
LEU A 298
LEU A 107
ARG A 132
ILE A 203
 None
 1.24A 1errA-3wwxA:
undetectable		 1errA-3wwxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 THR A  98
ALA A 151
LEU A 128
MET A 134
ILE A 168
 None
None
None
CL  A 503 ( 4.9A)
None
 1.17A 1errA-3zx2A:
undetectable		 1errA-3zx2A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akx EXOU

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 THR B 231
ALA B 234
LEU B 236
MET B 138
LEU B 269
 None
 1.14A 1errA-4akxB:
undetectable		 1errA-4akxB:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0n POLYKETIDE SYNTHASE
III

(Ectocarpus
siliculosus) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ALA A 311
ASP A 312
LEU A 315
ILE A 338
LEU A 347
 None
 1.25A 1errA-4b0nA:
undetectable		 1errA-4b0nA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8n CONJUGATED
POLYKETONE REDUCTASE
C2

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		5 THR A 242
ALA A 236
GLU A 237
LEU A 235
LEU A 220
 None
None
None
None
NDP  A3001 ( 4.2A)
 1.09A 1errA-4h8nA:
undetectable		 1errA-4h8nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 5 ALA D 272
LEU D 276
TRP D 305
ARG D 316
ILE D 428
 None
 1.05A 1errA-4j5xD:
22.2		 1errA-4j5xD:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 THR A 504
ASP A 501
LEU A 518
ILE A 485
LEU A 478
 None
 1.24A 1errA-4k17A:
undetectable		 1errA-4k17A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		5 THR A  41
ALA A  40
TRP A 255
LEU A 213
ILE A  27
 None
 1.11A 1errA-4mwzA:
undetectable		 1errA-4mwzA:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 ALA A 287
GLU A 290
LEU A 291
TRP A 320
ARG A 331
 None
 0.57A 1errA-4n1yA:
27.5		 1errA-4n1yA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 ALA A 287
GLU A 290
TRP A 320
ARG A 331
MET A 358
 None
 0.96A 1errA-4n1yA:
27.5		 1errA-4n1yA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnz PROBABLE ZINC
PROTEASE

(Pseudomonas
aeruginosa) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ALA A 393
ASP A 390
GLU A 392
LEU A 391
ILE A 402
 None
 1.24A 1errA-4nnzA:
undetectable		 1errA-4nnzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmd ENDO-1,4-BETA-XYLANA
SE

(Caldicellulosiruptor
bescii) 		PF00331
(Glyco_hydro_10) 		5 ALA A 107
ASP A 102
GLU A 106
ARG A 156
ILE A 165
 None
 1.14A 1errA-4pmdA:
undetectable		 1errA-4pmdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		5 GLU A 388
LEU A  44
LEU A 437
ARG A 475
ILE A 432
 None
 1.09A 1errA-4qvhA:
undetectable		 1errA-4qvhA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 ALA A 134
LEU A 131
LEU A 165
ILE A 119
LEU A  30
 None
 1.13A 1errA-4u1rA:
undetectable		 1errA-4u1rA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v39 SIALYLTRANSFERASE

(Pasteurella
dagmatis) 		PF11477
(PM0188) 		5 ASP A 121
GLU A 123
MET A 365
LEU A 368
ARG A 367
 None
 1.18A 1errA-4v39A:
undetectable		 1errA-4v39A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh0 PUTATIVE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		5 THR A 123
ALA A 126
GLU A 129
ILE A  82
LEU A  16
 None
 1.05A 1errA-4wh0A:
undetectable		 1errA-4wh0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjb PUTATIVE
AMIDOHYDROLASE/PEPTI
DASE

(Burkholderia
cenocepacia) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 THR A 399
ALA A 402
ASP A 403
LEU A 406
ILE A 101
 None
 1.14A 1errA-4wjbA:
undetectable		 1errA-4wjbA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Shewanella
loihica) 		PF01156
(IU_nuc_hydro) 		5 THR A  49
LEU A  45
LEU A  69
ARG A 104
LEU A 295
 None
 1.25A 1errA-4wr2A:
undetectable		 1errA-4wr2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo7 SUGAR ABC
TRANSPORTER
(SUGAR-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF13407
(Peripla_BP_4) 		5 ASP A 234
LEU A 238
MET A 216
LEU A 215
ILE A 226
 None
 1.21A 1errA-4yo7A:
undetectable		 1errA-4yo7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		5 THR A 206
ALA A 209
GLU A 212
LEU A 213
ILE A 186
 None
 0.71A 1errA-5allA:
undetectable		 1errA-5allA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 THR A  54
ALA A  56
ASP A  57
GLU A  59
LEU A  60
 None
 1.13A 1errA-5bswA:
undetectable		 1errA-5bswA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		5 THR A  28
ALA A  31
ASP A  32
LEU A  35
LEU A  67
 None
 1.21A 1errA-5dz6A:
undetectable		 1errA-5dz6A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzx NUDIX (NUCLEOSIDE
DIPHOSPHATE LINKED
MOIETY X)-TYPE MOTIF
1

(Danio rerio) 		PF00293
(NUDIX) 		5 ALA A  49
GLU A  52
LEU A  53
LEU A   7
ILE A  70
 None
None
None
2GE  A 201 ( 4.0A)
None
 1.09A 1errA-5hzxA:
undetectable		 1errA-5hzxA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 THR A 211
ALA A 214
GLU A 217
ARG A  95
LEU A 195
 None
 0.83A 1errA-5iq0A:
undetectable		 1errA-5iq0A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 THR L 168
ALA L 171
ASP L 172
LEU L 211
ILE L 206
 None
 1.12A 1errA-5jfcL:
undetectable		 1errA-5jfcL:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		5 THR A 566
ALA A 596
ASP A 593
LEU A 575
ILE A 561
 None
 1.26A 1errA-5jxrA:
undetectable		 1errA-5jxrA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxt CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		no annotation 5 THR B 566
ALA B 596
ASP B 593
LEU B 575
ILE B 561
 None
 1.25A 1errA-5jxtB:
undetectable		 1errA-5jxtB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m72 SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68
SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP72

(Homo sapiens) 		PF16969
(SRP68)
PF17004
(SRP_TPR_like) 		5 THR A  46
ALA A  47
ASP A  44
LEU A  31
LEU B 603
 None
 1.23A 1errA-5m72A:
undetectable		 1errA-5m72A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3)
PF14598
(PAS_11) 		5 ALA B 152
TRP B 108
LEU B 287
ILE B 142
LEU A 159
 None
 1.19A 1errA-5sy5B:
undetectable		 1errA-5sy5B:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 THR A 299
ALA A 302
GLU A 305
TRP A 335
MET A 340
LEU A 343
ARG A 346
ILE A 376
LEU A 476
 None
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
None
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-3.5A)
 0.78A 1errA-5toaA:
29.8		 1errA-5toaA:
57.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 THR A 299
GLU A 305
LEU A 306
TRP A 335
MET A 340
LEU A 343
ARG A 346
ILE A 376
LEU A 476
 None
EST  A 601 (-2.4A)
None
None
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-3.5A)
 0.90A 1errA-5toaA:
29.8		 1errA-5toaA:
57.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 5 ALA A 272
LEU A 276
TRP A 305
ARG A 316
ILE A 428
 9CR  A 503 (-3.5A)
None
None
9CR  A 503 (-3.0A)
None
 1.24A 1errA-5uanA:
21.7		 1errA-5uanA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 THR A 168
ALA A 171
ASP A 172
LEU A 211
ILE A 206
 None
 1.15A 1errA-5vj7A:
undetectable		 1errA-5vj7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3w ARYLDIALKYLPHOSPHATA
SE

(Sulfolobus
solfataricus) 		no annotation 5 ALA A 213
ASP A 214
LEU A 196
ILE A 253
LEU A 242
 None
 1.21A 1errA-5w3wA:
undetectable		 1errA-5w3wA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aoo MALATE DEHYDROGENASE

(Haemophilus
influenzae) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 THR A 297
ALA A 300
ASP A 301
GLU A 303
LEU A 304
 None
 0.68A 1errA-6aooA:
undetectable		 1errA-6aooA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 5 GLU A  49
LEU A  48
LEU A 301
ARG A 335
ILE A 290
 CL  A 402 ( 4.6A)
None
CL  A 402 (-4.8A)
CL  A 402 (-3.5A)
None
 1.01A 1errA-6dllA:
undetectable		 1errA-6dllA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0z PROTEIN
(PHOSPHOGLUCOSE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00342
(PGI) 		4 LEU A 376
LEU A 365
LEU A  19
LEU A  22
 None
 0.73A 1errA-1b0zA:
0.2		 1errA-1b0zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 279
LEU A 236
LEU A 269
LEU A 439
 None
 0.88A 1errA-1dj3A:
0.0		 1errA-1dj3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		4 LEU A 164
LEU A 216
HIS A  55
LEU A 139
 None
None
FAD  A 801 ( 4.9A)
None
 0.67A 1errA-1e1kA:
undetectable		 1errA-1e1kA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5a POLY(A) POLYMERASE

(Bos taurus) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 LEU A 105
HIS A 212
LEU A 190
LEU A 193
 None
 0.89A 1errA-1f5aA:
0.0		 1errA-1f5aA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipk BETA-CONGLYCININ,
BETA CHAIN

(Glycine max) 		PF00190
(Cupin_1)
PF07883
(Cupin_2) 		4 LEU A 125
LEU A 244
LEU A 111
LEU A  62
 None
 0.93A 1errA-1ipkA:
undetectable		 1errA-1ipkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 LEU A 644
LEU A 401
LEU A 681
LEU A 679
 None
 0.91A 1errA-1j0nA:
0.4		 1errA-1j0nA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B

(Escherichia
coli) 		PF02527
(GidB) 		4 LEU A  78
LEU A  83
LEU A  24
LEU A 199
 None
 0.84A 1errA-1jsxA:
0.8		 1errA-1jsxA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4i ANTIBODY VARIABLE
HEAVY CHAIN
ANTIBODY VARIABLE
LIGHT CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 LEU H 145
HIS L  50
LEU H  55
LEU H  74
 None
 0.90A 1errA-1p4iH:
undetectable		 1errA-1p4iH:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 346
LEU A 387
LEU A 428
HIS A 524
 EST  A   1 (-4.4A)
EST  A   1 (-4.0A)
None
EST  A   1 (-3.8A)
 0.50A 1errA-1pcgA:
32.5		 1errA-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)
RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (SMALL CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
no annotation 		4 LEU A 390
LEU A 170
HIS A 383
LEU M  18
 None
 0.91A 1errA-1rblA:
undetectable		 1errA-1rblA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		4 LEU A  98
LEU A 273
LEU A  52
LEU A  55
 None
 0.91A 1errA-1taqA:
undetectable		 1errA-1taqA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		4 LEU C 788
LEU C 798
LEU C 767
LEU C 770
 None
 0.83A 1errA-1wa5C:
undetectable		 1errA-1wa5C:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cv6 SEED STORAGE PROTEIN

(Vigna radiata) 		PF00190
(Cupin_1) 		4 LEU A 130
LEU A 255
LEU A 116
LEU A  67
 None
 0.94A 1errA-2cv6A:
undetectable		 1errA-2cv6A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbs HYPOTHETICAL PROTEIN
TTHC002

(Thermus
thermophilus) 		no annotation 4 LEU A  11
LEU A  39
LEU A  28
LEU A  25
 None
 0.92A 1errA-2dbsA:
undetectable		 1errA-2dbsA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 4 LEU A  92
LEU A  97
LEU A  67
LEU A  70
 None
 0.91A 1errA-2f9rA:
undetectable		 1errA-2f9rA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guu ODCASE

(Plasmodium
vivax) 		PF00215
(OMPdecase) 		4 LEU A 188
LEU A 140
LEU A 293
LEU A 320
 None
 0.90A 1errA-2guuA:
undetectable		 1errA-2guuA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		4 LEU A 464
LEU A 368
LEU A 417
LEU A 414
 None
 0.92A 1errA-2ja2A:
undetectable		 1errA-2ja2A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 346
LEU A 387
LEU A 428
HIS A 524
 EST  A 596 (-4.4A)
EST  A 596 ( 4.2A)
None
EST  A 596 (-4.2A)
 0.50A 1errA-2ocfA:
31.6		 1errA-2ocfA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		4 LEU A  37
LEU A 112
LEU A 119
LEU A 249
 None
 0.92A 1errA-2p35A:
undetectable		 1errA-2p35A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 LEU A 131
LEU A 161
LEU A 248
LEU A 253
 None
 0.92A 1errA-2q6zA:
undetectable		 1errA-2q6zA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qj9 BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE IA

(Homo sapiens) 		no annotation 4 LEU D 111
LEU D  73
HIS D  43
LEU D  36
 None
 0.85A 1errA-2qj9D:
undetectable		 1errA-2qj9D:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU A 768
LEU A 784
LEU A 813
LEU A 779
 None
 0.79A 1errA-2wfhA:
undetectable		 1errA-2wfhA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		4 LEU A 169
HIS A  92
LEU A  59
LEU A  62
 None
UPG  A1415 (-4.6A)
None
None
 0.94A 1errA-2xa2A:
undetectable		 1errA-2xa2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 LEU A1094
LEU A1051
LEU A1184
LEU A1195
 None
 0.91A 1errA-2xt6A:
undetectable		 1errA-2xt6A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwg SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		4 LEU A 167
LEU A 201
LEU A 216
LEU A 230
 None
 0.94A 1errA-2xwgA:
undetectable		 1errA-2xwgA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 LEU A 634
LEU A 997
LEU A1009
LEU A 820
 None
 0.90A 1errA-2y3aA:
1.9		 1errA-2y3aA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		4 LEU A 214
LEU A 194
LEU A 185
LEU A 219
 None
 0.80A 1errA-2ychA:
undetectable		 1errA-2ychA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		4 LEU A 284
LEU A 276
LEU A 113
LEU A 110
 None
GOL  A 501 ( 3.6A)
None
None
 0.93A 1errA-2yysA:
undetectable		 1errA-2yysA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byw PUTATIVE
ARABINOFURANOSYLTRAN
SFERASE

(Corynebacterium
diphtheriae) 		PF04602
(Arabinose_trans) 		4 LEU A 100
LEU A  88
LEU A  83
LEU A  57
 None
 0.84A 1errA-3bywA:
undetectable		 1errA-3bywA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqg NUCLEAR PORE COMPLEX
PROTEIN NUP107

(Homo sapiens) 		PF04121
(Nup84_Nup100) 		4 LEU A 875
LEU A 865
LEU A 821
LEU A 822
 None
 0.83A 1errA-3cqgA:
undetectable		 1errA-3cqgA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3k ENHANCER OF
MRNA-DECAPPING
PROTEIN 3

(Homo sapiens) 		PF03853
(YjeF_N) 		4 LEU A 411
LEU A 339
LEU A 399
LEU A 305
 None
 0.88A 1errA-3d3kA:
undetectable		 1errA-3d3kA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db1 STS-2 PROTEIN

(Mus musculus) 		PF00300
(His_Phos_1) 		4 LEU A 547
LEU A 583
LEU A 495
LEU A 492
 None
 0.86A 1errA-3db1A:
undetectable		 1errA-3db1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxq CHOLINE/ETHANOLAMINE
KINASE FAMILY
PROTEIN

(Mesorhizobium
loti) 		PF01633
(Choline_kinase) 		4 LEU A 284
LEU A 294
LEU A 255
LEU A 258
 None
 0.87A 1errA-3dxqA:
undetectable		 1errA-3dxqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 165
LEU A 168
LEU A 152
LEU A  89
 None
35F  A   1 (-4.5A)
None
None
 0.74A 1errA-3e7oA:
undetectable		 1errA-3e7oA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU A  55
LEU A  62
LEU A 112
LEU A  81
 None
 0.91A 1errA-3fgqA:
undetectable		 1errA-3fgqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		4 LEU A 105
LEU A 149
LEU A 205
LEU A  66
 GOL  A 312 (-4.3A)
None
None
None
 0.81A 1errA-3hc1A:
1.9		 1errA-3hc1A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 374
LEU A 360
LEU A 306
LEU A 304
 None
 0.92A 1errA-3hd8A:
undetectable		 1errA-3hd8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 LEU A 425
LEU A 461
LEU A 387
LEU A 390
 None
 0.89A 1errA-3nafA:
undetectable		 1errA-3nafA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		4 LEU A 454
LEU A 425
HIS A 413
LEU A 365
 None
 0.78A 1errA-3nawA:
undetectable		 1errA-3nawA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		5 LEU B 466
LEU B 518
HIS B 460
LEU B 420
LEU B 422
 None
 1.49A 1errA-3ojaB:
undetectable		 1errA-3ojaB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqc UFM1-SPECIFIC
PROTEASE 2

(Mus musculus) 		PF07910
(Peptidase_C78) 		4 LEU A 205
LEU A 215
LEU A  33
LEU A  36
 None
 0.87A 1errA-3oqcA:
undetectable		 1errA-3oqcA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE

(Pseudomonas
aeruginosa) 		PF01048
(PNP_UDP_1) 		4 LEU A  62
LEU A  32
LEU A 213
LEU A 211
 None
 0.88A 1errA-3ozbA:
undetectable		 1errA-3ozbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		4 LEU A 180
LEU A  79
LEU A 290
LEU A 287
 None
 0.77A 1errA-3p8lA:
undetectable		 1errA-3p8lA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p94 GDSL-LIKE LIPASE

(Parabacteroides
distasonis) 		PF13472
(Lipase_GDSL_2) 		4 LEU A 104
LEU A 126
LEU A 195
LEU A 199
 None
 0.69A 1errA-3p94A:
undetectable		 1errA-3p94A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 LEU A 811
LEU A 762
LEU A 830
LEU A1069
 None
 0.84A 1errA-3qcwA:
undetectable		 1errA-3qcwA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qit POLYKETIDE SYNTHASE

(Moorea
producens) 		PF00561
(Abhydrolase_1) 		4 LEU A  79
HIS A  61
LEU A  96
LEU A 120
 None
 0.70A 1errA-3qitA:
undetectable		 1errA-3qitA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzy BACULOVIRUS
SULFHYDRYL OXIDASE
AC92

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF05214
(Baculo_p33) 		4 LEU A  22
LEU A 116
LEU A  94
LEU A  92
 None
 0.91A 1errA-3qzyA:
undetectable		 1errA-3qzyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1p ALPHA-1-ANTITRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU A 353
LEU A 172
LEU A  80
LEU A  77
 None
 0.86A 1errA-3t1pA:
undetectable		 1errA-3t1pA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 LEU A 170
HIS A 101
LEU A  69
LEU A  79
 None
 0.94A 1errA-3vm5A:
undetectable		 1errA-3vm5A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 663
HIS A 645
LEU A 628
LEU A 598
 None
 0.78A 1errA-3wpeA:
undetectable		 1errA-3wpeA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		4 LEU A 527
LEU A 546
LEU A 615
LEU A 612
 None
 0.88A 1errA-3wxoA:
undetectable		 1errA-3wxoA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		4 LEU A 149
LEU A 693
LEU A 651
LEU A 262
 None
 0.84A 1errA-3zgbA:
2.6		 1errA-3zgbA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		4 LEU A 426
LEU A 398
LEU A 276
LEU A 279
 None
 0.74A 1errA-4bq4A:
undetectable		 1errA-4bq4A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 809
LEU A 802
HIS A 696
LEU A 677
 None
None
ZN  A1001 (-3.4A)
None
 0.88A 1errA-4htzA:
undetectable		 1errA-4htzA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE

(Trypanosoma
cruzi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 132
LEU A 124
LEU A  29
LEU A  32
 None
 0.94A 1errA-4iv5A:
undetectable		 1errA-4iv5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU A 405
LEU A 434
LEU A 400
LEU A 376
 None
 0.92A 1errA-4kngA:
undetectable		 1errA-4kngA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp2 HOMOACONITASE LARGE
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		4 LEU A 380
LEU A 373
HIS A 278
LEU A 173
 None
 0.86A 1errA-4kp2A:
undetectable		 1errA-4kp2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 LEU A 270
LEU A 404
LEU A 304
LEU A 309
 LEU  A 270 ( 0.6A)
LEU  A 404 ( 0.6A)
LEU  A 304 ( 0.6A)
LEU  A 309 ( 0.6A)
 0.57A 1errA-4kqnA:
undetectable		 1errA-4kqnA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kry ACETYL ESTERASE

(Escherichia
coli) 		PF07859
(Abhydrolase_3) 		4 LEU A 170
LEU A 229
LEU A 247
LEU A 275
 None
 0.87A 1errA-4kryA:
undetectable		 1errA-4kryA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C

(Homo sapiens) 		PF10294
(Methyltransf_16) 		4 LEU A 117
LEU A 149
LEU A 256
LEU A 246
 None
 0.94A 1errA-4mtlA:
undetectable		 1errA-4mtlA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		4 LEU A 613
LEU A 663
LEU A 568
LEU A 565
 None
 0.83A 1errA-4ppmA:
undetectable		 1errA-4ppmA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 4 LEU B 179
LEU B  75
LEU B  62
LEU B  59
 None
 0.90A 1errA-4r0mB:
undetectable		 1errA-4r0mB:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r10 PROTEIN HUMPBACK-2

(Caenorhabditis
elegans) 		PF00514
(Arm) 		4 LEU A 233
LEU A 210
LEU A 246
LEU A 165
 None
 0.83A 1errA-4r10A:
undetectable		 1errA-4r10A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN SAC3

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		4 LEU A 544
LEU A 532
LEU A 342
LEU A 345
 None
 0.86A 1errA-4trqA:
undetectable		 1errA-4trqA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU A 217
LEU A 246
LEU A 212
LEU A 188
 None
 0.93A 1errA-4ufsA:
undetectable		 1errA-4ufsA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 LEU B 423
LEU B 360
LEU B 429
LEU B  92
 None
 0.90A 1errA-4um8B:
undetectable		 1errA-4um8B:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU A 254
LEU A 283
LEU A 249
LEU A 227
 None
 0.93A 1errA-4v2eA:
undetectable		 1errA-4v2eA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		4 LEU B 734
LEU B 697
LEU B 678
LEU B 264
 None
 0.77A 1errA-4yg8B:
undetectable		 1errA-4yg8B:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 LEU A 163
LEU A 166
LEU A 150
LEU A  87
 None
ANP  A 401 ( 4.5A)
None
None
 0.87A 1errA-5awmA:
undetectable		 1errA-5awmA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsy POLY [ADP-RIBOSE]
POLYMERASE 2

(Homo sapiens) 		PF00644
(PARP) 		4 LEU A 412
HIS A 415
LEU A 391
LEU A 359
 None
UHB  A1001 (-3.7A)
None
None
 0.88A 1errA-5dsyA:
undetectable		 1errA-5dsyA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elt KH
DOMAIN-CONTAINING,
RNA-BINDING, SIGNAL
TRANSDUCTION-ASSOCIA
TED PROTEIN 3

(Homo sapiens) 		no annotation 4 LEU B  56
LEU B 148
LEU B  87
LEU B  84
 None
None
None
A  E   2 ( 4.8A)
 0.85A 1errA-5eltB:
undetectable		 1errA-5eltB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 390
LEU A 364
LEU A 321
LEU A 324
 None
 0.74A 1errA-5elxA:
undetectable		 1errA-5elxA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1024
LEU A1165
LEU A1128
LEU A1124
 None
 0.94A 1errA-5f1zA:
undetectable		 1errA-5f1zA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwj HISTONE DEMETHYLASE
JARID1C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2) 		4 LEU A 716
LEU A 747
LEU A 760
LEU A 763
 None
 0.93A 1errA-5fwjA:
undetectable		 1errA-5fwjA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5p NUCLEAR MRNA EXPORT
PROTEIN SAC3

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		4 LEU A 544
LEU A 532
LEU A 342
LEU A 345
 None
 0.94A 1errA-5g5pA:
undetectable		 1errA-5g5pA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		4 LEU A 622
LEU A 555
HIS A 573
LEU A 439
 None
 0.89A 1errA-5gggA:
undetectable		 1errA-5gggA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 LEU A  81
LEU A 105
LEU A 170
LEU A 177
 None
 0.73A 1errA-5gjeA:
undetectable		 1errA-5gjeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		4 LEU A 481
LEU A 645
LEU A 369
LEU A 365
 None
 0.89A 1errA-5gslA:
undetectable		 1errA-5gslA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 LEU A 443
LEU A 504
LEU A 478
LEU A 549
 PPI  A 808 (-4.0A)
None
None
None
 0.69A 1errA-5gsmA:
undetectable		 1errA-5gsmA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwo PROBABLE PROTEIN
PHOSPHATASE 2C 50

(Oryza sativa) 		PF00481
(PP2C) 		4 LEU A 109
LEU A 207
LEU A  97
LEU A 100
 None
 0.78A 1errA-5gwoA:
undetectable		 1errA-5gwoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl3 LMO2470 PROTEIN

(Listeria
monocytogenes) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 LEU A 226
LEU A 253
LEU A 221
LEU A 199
 None
 0.93A 1errA-5hl3A:
undetectable		 1errA-5hl3A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		4 LEU A 229
LEU A 316
LEU A 394
LEU A 390
 None
 0.80A 1errA-5hlbA:
undetectable		 1errA-5hlbA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		4 LEU B  98
LEU B 143
LEU B 105
LEU B  84
 None
 0.90A 1errA-5hz1B:
undetectable		 1errA-5hz1B:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iu9 PROTOCADHERIN-19
ISOFORM 1

(Danio rerio) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 LEU A 373
LEU A 398
LEU A 325
LEU A 388
 None
 0.91A 1errA-5iu9A:
undetectable		 1errA-5iu9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 LEU A 310
LEU A 625
LEU A 566
LEU A 569
 None
 0.93A 1errA-5k3hA:
2.1		 1errA-5k3hA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 LEU A 204
LEU A 231
LEU A 199
LEU A 175
 None
 0.94A 1errA-5kzsA:
undetectable		 1errA-5kzsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3t NUCLEAR MRNA EXPORT
PROTEIN SAC3

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		4 LEU A 544
LEU A 532
LEU A 342
LEU A 345
 None
 0.94A 1errA-5l3tA:
undetectable		 1errA-5l3tA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 4 LEU D  35
LEU D 226
LEU D  65
HIS D 230
 None
 0.90A 1errA-5llyD:
undetectable		 1errA-5llyD:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 LEU A 613
LEU A 977
LEU A 989
LEU A 800
 None
 0.90A 1errA-5m6uA:
undetectable		 1errA-5m6uA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN12
26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF08375
(Rpn3_C)
PF10075
(CSN8_PSD8_EIF3K) 		4 LEU S 372
HIS T 132
LEU T 110
LEU T 113
 None
 0.88A 1errA-5mpdS:
undetectable		 1errA-5mpdS:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx0 FIBROMODULIN

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 207
LEU A 235
LEU A 202
LEU A 178
 None
 0.88A 1errA-5mx0A:
undetectable		 1errA-5mx0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		no annotation 4 LEU A 591
LEU A 381
LEU A 511
LEU A 435
 None
 0.86A 1errA-5nfuA:
undetectable		 1errA-5nfuA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 4 LEU A 474
HIS A 576
LEU A 622
LEU A 660
 None
 0.93A 1errA-5ohsA:
undetectable		 1errA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 2
CONDENSIN COMPLEX
SUBUNIT 3

(Schizosaccharomyces
pombe) 		no annotation 4 LEU A 504
LEU A 551
LEU A 522
LEU C 531
 None
 0.85A 1errA-5oqrA:
undetectable		 1errA-5oqrA:
15.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 298
LEU A 339
LEU A 380
HIS A 475
 EST  A 601 (-4.1A)
EST  A 601 (-3.9A)
None
EST  A 601 (-4.4A)
 0.45A 1errA-5toaA:
29.8		 1errA-5toaA:
57.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		4 LEU A 544
LEU A 532
LEU A 342
LEU A 345
 None
 0.91A 1errA-5ubpA:
undetectable		 1errA-5ubpA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue0 CT622 PROTEIN

(Chlamydia
trachomatis) 		no annotation 4 LEU A 558
LEU A 639
LEU A 548
LEU A 515
 None
 0.91A 1errA-5ue0A:
undetectable		 1errA-5ue0A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbu CYTOCHROME P450
21-HYDROXYLASE

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 216
LEU A 224
HIS A 204
LEU A  38
 None
 0.77A 1errA-5vbuA:
undetectable		 1errA-5vbuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdi UBIQUITIN-ASSOCIATED
AND SH3
DOMAIN-CONTAINING
PROTEIN A

(Homo sapiens) 		PF00300
(His_Phos_1) 		4 LEU A 584
LEU A 620
LEU A 532
LEU A 529
 None
 0.78A 1errA-5wdiA:
undetectable		 1errA-5wdiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Enterococcus
faecalis) 		no annotation 4 LEU A 185
LEU A 200
LEU A  35
LEU A  41
 None
 0.84A 1errA-6c8qA:
undetectable		 1errA-6c8qA:
15.14