SIMILAR PATTERNS OF AMINO ACIDS FOR 1ERE_F_ESTF600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		4 ALA A 330
LEU A 361
LEU A 362
ARG A 219
 None
 0.91A 1ereF-1c7jA:
undetectable		 1ereF-1c7jA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 ALA A  59
GLU A  58
LEU A  20
ARG A 311
LEU A 109
 None
 1.35A 1ereF-1cj2A:
undetectable		 1ereF-1cj2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 GLU A 398
LEU A  53
LEU A  54
LEU A  46
 None
 0.96A 1ereF-1d8cA:
undetectable		 1ereF-1d8cA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 ALA A 307
GLU A 308
ARG A 364
LEU A 477
 None
 0.94A 1ereF-1fehA:
undetectable		 1ereF-1fehA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ALA A 192
GLU A 193
LEU A 349
LEU A 350
 None
 0.98A 1ereF-1fotA:
undetectable		 1ereF-1fotA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gs9 APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 GLU A 121
LEU A 133
LEU A 137
ARG A 114
 None
 0.82A 1ereF-1gs9A:
undetectable		 1ereF-1gs9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  48
GLU A  51
LEU A  78
LEU A  37
 None
 0.91A 1ereF-1h4lA:
undetectable		 1ereF-1h4lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ALA A 226
GLU A 229
LEU A 186
LEU A 183
 None
 0.89A 1ereF-1iqrA:
undetectable		 1ereF-1iqrA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		4 ALA A 290
GLU A 294
LEU A 253
LEU A 282
 None
 0.96A 1ereF-1j1uA:
undetectable		 1ereF-1j1uA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j4j TABTOXIN RESISTANCE
PROTEIN

(Pseudomonas
amygdali) 		PF13673
(Acetyltransf_10) 		4 MET A 123
LEU A  92
LEU A  73
LEU A 138
 None
 0.85A 1ereF-1j4jA:
undetectable		 1ereF-1j4jA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsw L-ASPARTATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ALA A  61
GLU A  64
LEU A 248
LEU A 230
 None
 0.94A 1ereF-1jswA:
0.4		 1ereF-1jswA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		4 MET A  58
ALA A  65
GLU A  68
LEU A  39
 None
 0.84A 1ereF-1l2qA:
undetectable		 1ereF-1l2qA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpe APOLIPOPROTEIN E3

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 GLU A 121
LEU A 133
LEU A 137
ARG A 114
 None
 0.74A 1ereF-1lpeA:
undetectable		 1ereF-1lpeA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqa TAS PROTEIN

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 ALA A  85
LEU A  82
ARG A  79
LEU A 306
 None
None
None
NDP  A1400 (-4.2A)
 0.86A 1ereF-1lqaA:
undetectable		 1ereF-1lqaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p50 ARGININE KINASE

(Limulus
polyphemus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ALA A  69
LEU A  81
HIS A  90
LEU A 275
 None
 0.90A 1ereF-1p50A:
undetectable		 1ereF-1p50A:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 350
LEU A 540
LEU A 539
LEU A 384
 EST  A   1 ( 3.7A)
None
None
None
 0.85A 1ereF-1pcgA:
37.9		 1ereF-1pcgA:
98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 MET A 343
ALA A 350
GLU A 353
LEU A 387
LEU A 391
ARG A 394
HIS A 524
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
 0.26A 1ereF-1pcgA:
37.9		 1ereF-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 MET A 138
ALA A 145
LEU A   6
LEU A  10
 None
 0.83A 1ereF-1pvdA:
undetectable		 1ereF-1pvdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ALA A  76
LEU A  88
HIS A  97
LEU A 287
 None
 0.88A 1ereF-1qh4A:
undetectable		 1ereF-1qh4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		4 ALA A1554
GLU A1452
LEU A1443
LEU A1470
 None
 0.89A 1ereF-1qhmA:
undetectable		 1ereF-1qhmA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 ALA A 129
LEU A 149
LEU A 125
LEU A 269
 None
 0.92A 1ereF-1qo8A:
undetectable		 1ereF-1qo8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 MET B 168
ALA B 174
LEU B 207
LEU B 112
 None
None
FAD  B1900 (-4.6A)
None
 0.96A 1ereF-1sb3B:
undetectable		 1ereF-1sb3B:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE

(Escherichia
coli) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		4 ALA A  29
LEU A  51
LEU A  47
LEU A 140
 None
 0.91A 1ereF-1sfeA:
undetectable		 1ereF-1sfeA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		5 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.19A 1ereF-1sgvA:
undetectable		 1ereF-1sgvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te2 2-DEOXYGLUCOSE-6-P
PHOSPHATASE

(Escherichia
coli) 		PF13419
(HAD_2) 		4 ALA A 100
GLU A  99
LEU A  93
LEU A 171
 None
 0.90A 1ereF-1te2A:
undetectable		 1ereF-1te2A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ALA A  75
LEU A  87
HIS A  96
LEU A 286
 None
 0.91A 1ereF-1u6rA:
undetectable		 1ereF-1u6rA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugo BCL2-ASSOCIATED
ATHANOGENE 5

(Mus musculus) 		PF02179
(BAG) 		5 ALA A  79
GLU A  83
LEU A  57
LEU A  53
LEU A  20
 None
 1.08A 1ereF-1ugoA:
undetectable		 1ereF-1ugoA:
15.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 343
LEU A 380
ARG A 387
LEU A 507
 MEI  A1001 (-3.3A)
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
MEI  A1001 (-4.6A)
 0.96A 1ereF-1uhlA:
25.9		 1ereF-1uhlA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w4t ARYLAMINE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00797
(Acetyltransf_2) 		4 ALA A  81
LEU A  91
HIS A 113
LEU A 114
 None
 0.70A 1ereF-1w4tA:
undetectable		 1ereF-1w4tA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w4t ARYLAMINE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00797
(Acetyltransf_2) 		4 GLU A  92
LEU A 183
HIS A 113
LEU A 114
 None
 0.70A 1ereF-1w4tA:
undetectable		 1ereF-1w4tA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2

(Infectious
bursal disease
virus) 		PF01766
(Birna_VP2) 		4 GLU J 135
LEU J 346
ARG J 204
LEU J 351
 None
 0.81A 1ereF-1wcdJ:
undetectable		 1ereF-1wcdJ:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Bacillus
subtilis) 		PF01368
(DHH) 		4 ALA A  64
GLU A  67
LEU A   5
ARG A  59
 None
 0.93A 1ereF-1wpnA:
undetectable		 1ereF-1wpnA:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 454
GLU A 457
HIS A 296
LEU A 297
 None
 0.96A 1ereF-1xb7A:
28.4		 1ereF-1xb7A:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 GLU A 331
LEU A 365
ARG A 372
HIS A 494
 None
 0.59A 1ereF-1xb7A:
28.4		 1ereF-1xb7A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		4 ALA A 246
LEU A 283
ARG A 290
LEU A 410
 9CR  A 201 (-3.6A)
9CR  A 201 ( 4.1A)
9CR  A 201 (-2.8A)
9CR  A 201 ( 4.8A)
 0.91A 1ereF-1xiuA:
23.4		 1ereF-1xiuA:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		4 ALA A 337
LEU A 367
LEU A 366
LEU A  30
 None
 0.96A 1ereF-1xkdA:
undetectable		 1ereF-1xkdA:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 272
LEU A 309
ARG A 316
LEU A 436
 9CR  A 801 (-3.5A)
9CR  A 801 (-4.2A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.7A)
 0.91A 1ereF-1xlsA:
25.5		 1ereF-1xlsA:
31.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yga HYPOTHETICAL 37.9
KDA PROTEIN IN
BIO3-HXT17
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		4 ALA A 268
LEU A 181
HIS A 233
LEU A 232
 None
 0.86A 1ereF-1ygaA:
undetectable		 1ereF-1ygaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 ALA A  65
LEU A  96
LEU A 124
LEU A  86
 None
 0.91A 1ereF-1yrgA:
undetectable		 1ereF-1yrgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4k 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 ALA A  14
LEU A  43
LEU A  42
LEU A  50
 None
 0.90A 1ereF-2a4kA:
undetectable		 1ereF-2a4kA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8q U8 SNORNA-BINDING
PROTEIN X29

(Xenopus laevis) 		PF00293
(NUDIX) 		4 MET A  61
ALA A  38
LEU A  86
LEU A  94
 None
 0.94A 1ereF-2a8qA:
undetectable		 1ereF-2a8qA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		4 ALA A 138
LEU A 136
LEU A 135
LEU A 187
 None
 0.74A 1ereF-2avnA:
undetectable		 1ereF-2avnA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bap DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		no annotation 4 MET B 266
ALA B 273
GLU B 276
LEU B 233
 None
 0.95A 1ereF-2bapB:
undetectable		 1ereF-2bapB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  62
GLU A  65
LEU A  96
LEU A  85
 None
 0.79A 1ereF-2bujA:
undetectable		 1ereF-2bujA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ce9 TRANSDUCIN-LIKE
ENHANCER PROTEIN 1

(Homo sapiens) 		PF00400
(WD40) 		4 ALA A 673
LEU A 704
HIS A 695
LEU A 694
 None
 0.77A 1ereF-2ce9A:
undetectable		 1ereF-2ce9A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 MET A 286
ALA A 331
GLU A 330
ARG A 344
 None
 0.95A 1ereF-2d52A:
undetectable		 1ereF-2d52A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4z TGTWINSCAN_2721 - E2
DOMAIN

(Toxoplasma
gondii) 		PF00179
(UQ_con) 		4 MET A 111
LEU A  41
LEU A  37
LEU A 148
 None
 0.82A 1ereF-2f4zA:
undetectable		 1ereF-2f4zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2

(Pseudomonas
syringae) 		PF05721
(PhyH) 		4 ALA A 124
GLU A 271
ARG A 100
LEU A 203
 None
 0.98A 1ereF-2fctA:
undetectable		 1ereF-2fctA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
GLU A 275
LEU A 309
ARG A 316
HIS A 434
 OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
 0.65A 1ereF-2gpvA:
26.5		 1ereF-2gpvA:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11

(Brucella suis) 		PF00437
(T2SSE) 		4 ALA A 266
GLU A 265
LEU A 261
LEU A 318
 None
 0.93A 1ereF-2gzaA:
undetectable		 1ereF-2gzaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haw MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Bacillus
subtilis) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 ALA A  64
GLU A  67
LEU A   5
ARG A  59
 None
 0.91A 1ereF-2hawA:
undetectable		 1ereF-2hawA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ALA A 428
LEU A 448
LEU A 444
ARG A 386
 None
 0.95A 1ereF-2hpiA:
undetectable		 1ereF-2hpiA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF12176
(MtaB) 		4 GLU B 165
LEU B 157
ARG A 133
LEU B 178
 None
 0.97A 1ereF-2i2xB:
undetectable		 1ereF-2i2xB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijc HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF02627
(CMD) 		4 ALA A  59
GLU A  64
LEU A  69
LEU A  72
 None
 0.97A 1ereF-2ijcA:
undetectable		 1ereF-2ijcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ALA A 192
LEU A 244
LEU A 247
LEU A 310
 None
 0.96A 1ereF-2ip4A:
undetectable		 1ereF-2ip4A:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 350
LEU A 540
LEU A 539
LEU A 384
 EST  A 596 ( 3.9A)
None
None
None
 0.97A 1ereF-2ocfA:
36.2		 1ereF-2ocfA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 MET A 343
ALA A 350
GLU A 353
LEU A 387
LEU A 391
ARG A 394
HIS A 524
LEU A 525
 EST  A 596 (-4.8A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
 0.44A 1ereF-2ocfA:
36.2		 1ereF-2ocfA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjq UNCHARACTERIZED
PROTEIN LP_2664

(Lactobacillus
plantarum) 		PF01966
(HD) 		4 ALA A  37
LEU A  52
LEU A  50
HIS A  58
 None
 0.97A 1ereF-2pjqA:
undetectable		 1ereF-2pjqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ALA A  50
GLU A  53
LEU A  80
LEU A  40
 None
AGS  A3001 ( 4.8A)
None
None
 0.87A 1ereF-2pmiA:
undetectable		 1ereF-2pmiA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ALA B  46
GLU B  47
HIS B 141
LEU B  60
 None
 0.92A 1ereF-2po2B:
undetectable		 1ereF-2po2B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		4 ALA A  44
LEU A  33
LEU A  40
LEU A  67
 None
 0.93A 1ereF-2psyA:
undetectable		 1ereF-2psyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		4 ALA A 265
LEU A 272
HIS A 233
LEU A 230
 None
 0.92A 1ereF-2q01A:
undetectable		 1ereF-2q01A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 ALA A 235
GLU A 232
LEU A 147
LEU A 154
 None
 0.98A 1ereF-2v9iA:
undetectable		 1ereF-2v9iA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 MET A 138
ALA A 145
LEU A   6
LEU A  10
 None
 0.85A 1ereF-2vk4A:
undetectable		 1ereF-2vk4A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtn EST1E

(Butyrivibrio
proteoclasticus) 		PF08386
(Abhydrolase_4)
PF12146
(Hydrolase_4) 		4 ALA A 237
LEU A 190
LEU A 217
HIS A 104
 None
None
None
GOL  A1249 (-3.8A)
 0.88A 1ereF-2wtnA:
undetectable		 1ereF-2wtnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuq BETA-LACTAMASE
REGULATORY PROTEIN
BLAB

(Streptomyces
cacaoi) 		PF13354
(Beta-lactamase2) 		4 MET A 144
ALA A 116
LEU A 101
LEU A  53
 None
 0.95A 1ereF-2wuqA:
undetectable		 1ereF-2wuqA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4l MANNOSYLGLYCERATE
SYNTHASE

(Rhodothermus
marinus) 		no annotation 4 MET A 229
ALA A 236
LEU A 194
LEU A 163
 MLI  A 402 ( 4.1A)
None
None
MLI  A 402 (-4.6A)
 0.79A 1ereF-2y4lA:
undetectable		 1ereF-2y4lA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		4 GLU A  28
LEU A  31
ARG A 261
LEU A 126
 None
BR  A1293 ( 4.6A)
None
None
 0.97A 1ereF-2ykfA:
undetectable		 1ereF-2ykfA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b90 ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		4 ALA A 271
LEU A 344
HIS A 247
LEU A 250
 None
 0.94A 1ereF-3b90A:
undetectable		 1ereF-3b90A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		4 MET P 157
GLU P 129
HIS P 115
LEU P 112
 None
 0.96A 1ereF-3c5wP:
undetectable		 1ereF-3c5wP:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cio TYROSINE-PROTEIN
KINASE ETK

(Escherichia
coli) 		PF13614
(AAA_31) 		4 ALA A 671
LEU A 669
LEU A 668
LEU A 459
 None
 0.88A 1ereF-3cioA:
undetectable		 1ereF-3cioA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 ALA A 272
LEU A 309
ARG A 316
LEU A 436
 9CR  A7223 (-4.2A)
9CR  A7223 ( 4.4A)
9CR  A7223 (-3.7A)
9CR  A7223 ( 4.7A)
 0.87A 1ereF-3dzuA:
25.4		 1ereF-3dzuA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-3

(Homo sapiens) 		PF09507
(CDC27) 		4 GLU B  82
LEU B  57
ARG B  49
LEU B 114
 None
 0.78A 1ereF-3e0jB:
undetectable		 1ereF-3e0jB:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 ALA A 482
LEU A 709
LEU A 708
LEU A 716
 None
 0.94A 1ereF-3e1sA:
undetectable		 1ereF-3e1sA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 426
LEU A 410
ARG A 494
LEU A 465
 None
 0.87A 1ereF-3e7wA:
undetectable		 1ereF-3e7wA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8j COPROPORPHYRINOGEN
III OXIDASE

(Leishmania
naiffi) 		PF01218
(Coprogen_oxidas) 		5 ALA A 180
GLU A 179
LEU A 290
ARG A 237
HIS A 146
 None
 1.36A 1ereF-3e8jA:
undetectable		 1ereF-3e8jA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE

(Bacillus
subtilis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.27A 1ereF-3egoA:
undetectable		 1ereF-3egoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emk GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		4 ALA A  74
GLU A  75
LEU A 122
ARG A 129
 None
 0.86A 1ereF-3emkA:
undetectable		 1ereF-3emkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ALA H  44
LEU H  33
LEU H  40
LEU H  68
 None
 0.95A 1ereF-3f6uH:
undetectable		 1ereF-3f6uH:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE

(Oenococcus oeni) 		PF12697
(Abhydrolase_6) 		4 ALA A  78
GLU A  81
LEU A   5
HIS A  25
 None
 0.77A 1ereF-3fsgA:
undetectable		 1ereF-3fsgA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)

(Streptomyces
matensis) 		PF16483
(Glyco_hydro_64) 		4 MET A 124
ALA A  91
LEU A 128
LEU A  60
 None
 0.95A 1ereF-3gd9A:
undetectable		 1ereF-3gd9A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 4 ALA A 206
GLU A 209
LEU A 239
ARG A 162
 None
 0.69A 1ereF-3gjyA:
undetectable		 1ereF-3gjyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ALA A 608
LEU A 331
LEU A 332
LEU A 324
 None
 0.78A 1ereF-3gm8A:
undetectable		 1ereF-3gm8A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		4 GLU A 221
LEU A 195
HIS A 151
LEU A 152
 None
 0.94A 1ereF-3i5gA:
undetectable		 1ereF-3i5gA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		4 GLU A 920
LEU A 901
ARG A 891
LEU A 942
 None
 0.91A 1ereF-3j9dA:
undetectable		 1ereF-3j9dA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 ALA A 440
LEU A 220
LEU A 215
LEU A 423
 None
 0.97A 1ereF-3k5wA:
undetectable		 1ereF-3k5wA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 GLU A 281
LEU A 257
LEU A 254
HIS A 239
 None
 0.91A 1ereF-3k5wA:
undetectable		 1ereF-3k5wA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 ALA B 163
LEU B 159
LEU B 158
LEU B 201
 None
 0.94A 1ereF-3k70B:
undetectable		 1ereF-3k70B:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 298
LEU A 385
HIS A 420
LEU A 424
 None
 0.84A 1ereF-3kmuA:
undetectable		 1ereF-3kmuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kux PUTATIVE
OXIDOREDUCTASE

(Yersinia pestis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ALA A 185
LEU A 225
ARG A 237
LEU A 329
 None
 0.84A 1ereF-3kuxA:
undetectable		 1ereF-3kuxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2h PUTATIVE SUGAR
PHOSPHATE ISOMERASE

(Acidithiobacillus
ferrooxidans) 		PF07883
(Cupin_2) 		5 GLU A  12
LEU A   8
LEU A   7
ARG A   4
LEU A  49
 None
None
None
None
CXS  A 164 (-4.4A)
 1.48A 1ereF-3l2hA:
undetectable		 1ereF-3l2hA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 ALA B 168
GLU B 167
LEU B  76
LEU B  95
 None
 0.90A 1ereF-3lcvB:
undetectable		 1ereF-3lcvB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		4 ALA A 136
LEU A 151
LEU A 150
LEU A 104
 None
 0.89A 1ereF-3lezA:
undetectable		 1ereF-3lezA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvg CLATHRIN HEAVY CHAIN
1

(Bos taurus) 		PF00637
(Clathrin) 		4 ALA A1568
LEU A1554
LEU A1558
LEU A1583
 None
 0.84A 1ereF-3lvgA:
undetectable		 1ereF-3lvgA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5r NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		4 MET A 104
ALA A 149
LEU A 146
LEU A 119
 None
 0.95A 1ereF-3m5rA:
undetectable		 1ereF-3m5rA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 MET B1000
ALA B1062
LEU B1088
LEU B1087
 None
 0.84A 1ereF-3p8cB:
undetectable		 1ereF-3p8cB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		4 ALA A 286
LEU A 265
LEU A 264
LEU A 272
 None
 0.79A 1ereF-3p8rA:
undetectable		 1ereF-3p8rA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0g ENOYL-COA HYDRATASE
ECHA8

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.37A 1ereF-3q0gA:
undetectable		 1ereF-3q0gA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 ALA A 247
LEU A 258
LEU A 234
LEU A 285
 None
 0.96A 1ereF-3qp9A:
undetectable		 1ereF-3qp9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL

(Homo sapiens) 		PF00271
(Helicase_C)
PF12513
(SUV3_C) 		4 GLU A 482
LEU A 354
ARG A 365
LEU A 494
 None
 0.96A 1ereF-3rc3A:
undetectable		 1ereF-3rc3A:
16.74