SIMILAR PATTERNS OF AMINO ACIDS FOR 1EQH_B_FLPB1701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au8 CATHEPSIN G

(Homo sapiens) 		PF00089
(Trypsin) 		6 VAL A  52
LEU A  68
ILE A  64
ALA A  85
SER A 109
LEU A 108
 None
 1.04A 1eqhB-1au8A:
0.0		 1eqhB-1au8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		6 VAL A 134
VAL A 117
ILE A 163
GLY A 164
SER A 168
LEU A 170
 None
 1.45A 1eqhB-1dysA:
0.0		 1eqhB-1dysA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.35A 1eqhB-1ebvA:
63.7		 1eqhB-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 VAL A  52
LEU B  67
ILE B  63
ALA B  85
SER B 109
LEU B 108
 None
 1.18A 1eqhB-1eptA:
undetectable		 1eqhB-1eptA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eq9 CHYMOTRYPSIN

(Solenopsis
invicta) 		PF00089
(Trypsin) 		5 VAL A  59
VAL A  52
ILE A 212
GLY A 197
LEU A  33
 None
 0.87A 1eqhB-1eq9A:
0.0		 1eqhB-1eq9A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A 289
ILE A  54
GLY A  31
ALA A  30
LEU A 291
 None
None
FAD  A 600 (-3.2A)
FAD  A 600 ( 4.8A)
None
 0.91A 1eqhB-1gpeA:
0.0		 1eqhB-1gpeA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		6 VAL A  52
LEU A  67
ILE A  63
ALA A  85
SER A 109
LEU A 108
 None
 1.17A 1eqhB-1h4wA:
0.0		 1eqhB-1h4wA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 VAL A 235
LEU A 226
ILE A 193
ALA A 215
LEU A 237
 None
 1.04A 1eqhB-1h6uA:
undetectable		 1eqhB-1h6uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 VAL E  52
LEU E  67
ILE E  63
ALA E  85
SER E 109
LEU E 108
 None
 1.18A 1eqhB-1h9hE:
0.0		 1eqhB-1h9hE:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		5 VAL A  27
TYR A 171
GLY A  50
ALA A  49
SER A  18
 None
 1.01A 1eqhB-1hixA:
undetectable		 1eqhB-1hixA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwu PII PROTEIN

(Herbaspirillum
seropedicae) 		PF00543
(P-II) 		5 VAL A  63
VAL A  16
LEU A  20
ILE A  91
ALA A   6
 None
 1.03A 1eqhB-1hwuA:
undetectable		 1eqhB-1hwuA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		5 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.03A 1eqhB-1i8dA:
undetectable		 1eqhB-1i8dA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		6 VAL T  52
LEU T  68
ILE T  63
ALA T  85
SER T 109
LEU T 108
 None
 1.16A 1eqhB-1j17T:
undetectable		 1eqhB-1j17T:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 VAL A2814
VAL A2795
LEU A2852
GLY A2798
ALA A2797
 None
 1.01A 1eqhB-1js8A:
undetectable		 1eqhB-1js8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.93A 1eqhB-1jy1A:
undetectable		 1eqhB-1jy1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		6 VAL A  43
VAL A 200
ILE A 190
GLY A 185
ALA A 189
LEU A  51
 None
None
None
NAD  A1201 ( 4.2A)
None
None
 1.50A 1eqhB-1kaeA:
undetectable		 1eqhB-1kaeA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		5 VAL H  52
LEU H 106
ILE H 212
GLY H 197
LEU H  33
 None
 1.03A 1eqhB-1kigH:
undetectable		 1eqhB-1kigH:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		5 VAL A 332
LEU A  81
GLY A 179
ALA A 178
LEU A 125
 None
 0.93A 1eqhB-1l8wA:
undetectable		 1eqhB-1l8wA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n12 MATURE FIMBRIAL
PROTEIN PAPE

(Escherichia
coli) 		PF00419
(Fimbrial) 		5 VAL A  57
LEU A 144
ILE A 109
GLY A 107
LEU A 120
 None
 0.85A 1eqhB-1n12A:
undetectable		 1eqhB-1n12A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 6 VAL A 116
VAL A  94
ILE A 139
GLY A  99
ALA A 100
SER A  12
 None
 1.23A 1eqhB-1oy1A:
0.7		 1eqhB-1oy1A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 VAL A 558
VAL A 606
LEU A 615
GLY A 593
LEU A 560
 None
 0.86A 1eqhB-1ps9A:
undetectable		 1eqhB-1ps9A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzx HYPOTHETICAL PROTEIN
APC36103

(Geobacillus
stearothermophilus) 		PF02645
(DegV) 		5 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 0.99A 1eqhB-1pzxA:
undetectable		 1eqhB-1pzxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		6 VAL A  36
LEU A 152
ILE A  43
GLY A  41
ALA A  44
LEU A  57
 None
 1.40A 1eqhB-1toaA:
undetectable		 1eqhB-1toaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhb TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 VAL A  52
LEU A  67
ILE A  63
ALA A  85
SER A 109
LEU A 108
 None
 1.18A 1eqhB-1uhbA:
undetectable		 1eqhB-1uhbA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		5 VAL A 494
VAL A 372
LEU A 375
ILE A 614
LEU A 492
 None
 1.00A 1eqhB-1w7cA:
undetectable		 1eqhB-1w7cA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynq OXIDOREDUCTASE

(Bacillus
halodurans) 		PF00248
(Aldo_ket_red) 		5 VAL A 270
VAL A 195
TYR A  51
GLY A 256
ALA A 255
 None
None
SO4  A 300 ( 4.9A)
SO4  A 300 (-3.8A)
SO4  A 300 (-4.0A)
 0.87A 1eqhB-1ynqA:
undetectable		 1eqhB-1ynqA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Homo sapiens) 		PF01424
(R3H)
PF04857
(CAF1) 		5 VAL A 284
LEU A 322
ILE A 274
ALA A 278
SER A 280
 None
 0.94A 1eqhB-2a1rA:
undetectable		 1eqhB-2a1rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9c SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		6 VAL A 306
LEU A 270
ILE A 256
GLY A 259
ALA A 261
LEU A 223
 None
 1.29A 1eqhB-2a9cA:
undetectable		 1eqhB-2a9cA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aiz OUTER MEMBRANE
PROTEIN P6

(Haemophilus
influenzae) 		PF00691
(OmpA) 		5 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.02A 1eqhB-2aizP:
undetectable		 1eqhB-2aizP:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 VAL A 120
VAL A  82
ILE A  31
GLY A 106
ALA A 109
 None
 0.99A 1eqhB-2d0dA:
undetectable		 1eqhB-2d0dA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh8 DAZ-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL A  67
TYR A  29
ILE A  80
GLY A  15
LEU A  12
 None
 1.03A 1eqhB-2dh8A:
undetectable		 1eqhB-2dh8A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		5 VAL A  32
LEU A  49
GLY A  12
ALA A  13
LEU A  34
 None
None
NAD  A 300 (-3.3A)
None
None
 1.04A 1eqhB-2gdzA:
undetectable		 1eqhB-2gdzA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnj PUTATIVE
UNCHARACTERIZED
PROTEIN SLL1418

(Synechocystis
sp. PCC 6803) 		PF01789
(PsbP) 		5 VAL A 152
LEU A  92
GLY A  61
SER A  81
LEU A 159
 None
 0.93A 1eqhB-2lnjA:
undetectable		 1eqhB-2lnjA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A1538
ILE A1641
GLY A1595
ALA A1596
LEU A1600
 None
 0.84A 1eqhB-2pffA:
undetectable		 1eqhB-2pffA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		5 VAL A 203
LEU A  26
ILE A  30
GLY A 261
LEU A 267
 None
 1.02A 1eqhB-2r98A:
undetectable		 1eqhB-2r98A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmh FIBRONECTIN TYPE III
DOMAIN PROTEIN

(Clostridium
perfringens) 		PF08305
(NPCBM) 		5 TYR A 962
LEU A1026
ILE A 952
GLY A1045
ALA A1047
 None
 1.02A 1eqhB-2vmhA:
undetectable		 1eqhB-2vmhA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 VAL A  90
VAL A 290
LEU A 293
GLY A 244
ALA A 243
 HEM  A 450 (-3.2A)
HEM  A 450 (-4.6A)
HEM  A 450 (-4.4A)
HEM  A 450 (-3.4A)
HEM  A 450 (-3.5A)
 0.95A 1eqhB-2wgyA:
undetectable		 1eqhB-2wgyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA

(Escherichia
coli) 		PF13580
(SIS_2) 		5 VAL A 140
LEU A 114
ILE A  27
ALA A  31
LEU A  34
 None
 0.97A 1eqhB-2yvaA:
1.0		 1eqhB-2yvaA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 485
GLY A 524
ALA A 525
SER A 527
LEU A 529
 None
 1.03A 1eqhB-2z1qA:
undetectable		 1eqhB-2z1qA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brk GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00483
(NTP_transferase) 		5 VAL X 376
VAL X  38
LEU X  29
GLY X  41
LEU X 361
 None
 1.03A 1eqhB-3brkX:
undetectable		 1eqhB-3brkX:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		5 VAL A 282
ILE A 234
GLY A 238
ALA A 237
LEU A 337
 None
 0.97A 1eqhB-3d0qA:
undetectable		 1eqhB-3d0qA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		5 VAL A 277
LEU A 315
ILE A 267
ALA A 271
SER A 273
 None
 0.91A 1eqhB-3d45A:
undetectable		 1eqhB-3d45A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egc PUTATIVE RIBOSE
OPERON REPRESSOR

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		5 VAL A 275
ILE A 190
GLY A 259
ALA A 260
LEU A 264
 None
 0.89A 1eqhB-3egcA:
undetectable		 1eqhB-3egcA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emk GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		5 VAL A  33
LEU A  50
GLY A  13
ALA A  14
LEU A  35
 None
 1.00A 1eqhB-3emkA:
undetectable		 1eqhB-3emkA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		5 VAL A 200
VAL A 251
LEU A 253
GLY A 182
LEU A 207
 None
 1.01A 1eqhB-3gxoA:
undetectable		 1eqhB-3gxoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 VAL A 301
ILE A 307
ALA A 385
SER A 388
LEU A 389
 None
 1.01A 1eqhB-3hz6A:
undetectable		 1eqhB-3hz6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00271
(Helicase_C) 		5 VAL A 339
VAL A 228
LEU A 232
GLY A 343
LEU A 341
 None
 1.04A 1eqhB-3i32A:
undetectable		 1eqhB-3i32A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		5 VAL A 523
ILE A 502
GLY A 565
ALA A 566
LEU A 570
 None
 1.02A 1eqhB-3ifqA:
undetectable		 1eqhB-3ifqA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khn MOTB PROTEIN,
PUTATIVE

(Desulfovibrio
vulgaris) 		PF00691
(OmpA) 		5 VAL A 116
VAL A  49
GLY A  65
ALA A  66
LEU A  70
 None
 0.90A 1eqhB-3khnA:
undetectable		 1eqhB-3khnA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 VAL A 108
LEU A 112
GLY A  76
SER A  79
LEU A  80
 None
None
AKG  A 224 (-3.1A)
None
None
 0.87A 1eqhB-3la2A:
undetectable		 1eqhB-3la2A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		5 VAL A  28
TYR A 171
GLY A  51
ALA A  50
SER A  19
 None
 0.94A 1eqhB-3mf9A:
undetectable		 1eqhB-3mf9A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		5 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 0.97A 1eqhB-3nixA:
undetectable		 1eqhB-3nixA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 LEU A  78
ILE A  12
GLY A  14
ALA A  16
SER A  18
 None
 0.98A 1eqhB-3nksA:
undetectable		 1eqhB-3nksA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3num SERINE PROTEASE
HTRA1

(Homo sapiens) 		PF13365
(Trypsin_2) 		5 VAL A 209
LEU A 364
ILE A 342
GLY A 341
LEU A 267
 None
 0.98A 1eqhB-3numA:
undetectable		 1eqhB-3numA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5t PII-LIKE PROTEIN PZ

(Azospirillum
brasilense) 		PF00543
(P-II) 		5 VAL B  63
VAL B  16
LEU B  20
ILE B  91
ALA B   6
 ADP  B 113 (-4.1A)
None
None
None
None
 0.97A 1eqhB-3o5tB:
undetectable		 1eqhB-3o5tB:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		5 VAL A 248
VAL A 220
LEU A 260
ILE A 353
LEU A 389
 None
 1.04A 1eqhB-3p24A:
undetectable		 1eqhB-3p24A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		5 LEU A  41
ILE A  59
GLY A  61
ALA A  60
LEU A  68
 None
 1.02A 1eqhB-3q1yA:
undetectable		 1eqhB-3q1yA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r18 SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		6 VAL A 306
LEU A 270
ILE A 256
GLY A 259
ALA A 261
LEU A 223
 None
 1.30A 1eqhB-3r18A:
undetectable		 1eqhB-3r18A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A 485
VAL A 272
LEU A 267
GLY A 479
LEU A 483
 None
 1.02A 1eqhB-3redA:
undetectable		 1eqhB-3redA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		5 VAL B 246
LEU B 229
ILE B 216
GLY B 218
LEU B 250
 None
 0.99A 1eqhB-3s4wB:
undetectable		 1eqhB-3s4wB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukf UDP-GALACTOPYRANOSE
MUTASE

(Aspergillus
fumigatus) 		PF13450
(NAD_binding_8) 		5 VAL A  10
TYR A  71
GLY A  21
ALA A  22
LEU A  26
 None
 0.95A 1eqhB-3ukfA:
undetectable		 1eqhB-3ukfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 TYR A 247
GLY A 216
ALA A 218
SER A 220
LEU A 221
 None
KCX  A 219 ( 4.5A)
KCX  A 219 ( 3.1A)
KCX  A 219 ( 4.3A)
None
 0.91A 1eqhB-4c13A:
undetectable		 1eqhB-4c13A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dna PROBABLE GLUTATHIONE
REDUCTASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 VAL A 260
LEU A 151
ILE A 199
GLY A 177
ALA A 176
LEU A 262
 None
 1.29A 1eqhB-4dnaA:
undetectable		 1eqhB-4dnaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsq PEROXIREDOXIN TYPE-2

(Saccharomyces
cerevisiae) 		PF08534
(Redoxin) 		5 VAL A 106
VAL A  86
ILE A  67
GLY A  69
LEU A  74
 None
 1.02A 1eqhB-4dsqA:
undetectable		 1eqhB-4dsqA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		5 VAL A 322
LEU A 259
ILE A 272
GLY A  22
LEU A 308
 None
 1.00A 1eqhB-4e8dA:
undetectable		 1eqhB-4e8dA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehc PE-PGRS FAMILY
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 VAL A  21
VAL A 142
ILE A 130
GLY A 117
LEU A  35
 None
 1.04A 1eqhB-4ehcA:
undetectable		 1eqhB-4ehcA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomyces
pombe) 		no annotation 5 VAL B 155
LEU B  62
ALA B  80
SER B  83
LEU B  84
 None
 1.04A 1eqhB-4fcxB:
undetectable		 1eqhB-4fcxB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 VAL A 241
ILE A 205
ALA A 203
SER A 202
LEU A 223
 None
 0.94A 1eqhB-4hzzA:
undetectable		 1eqhB-4hzzA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijn ACETATE KINASE

(Mycolicibacterium
smegmatis) 		PF00871
(Acetate_kinase) 		5 VAL A  74
ILE A 109
GLY A 111
ALA A 108
SER A   9
 EDO  A 404 (-3.9A)
None
None
None
None
 1.01A 1eqhB-4ijnA:
undetectable		 1eqhB-4ijnA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		6 VAL A 479
TYR A 411
LEU A 420
ILE A 424
ALA A 337
LEU A 384
 None
 1.32A 1eqhB-4jcmA:
undetectable		 1eqhB-4jcmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		5 VAL A 993
ILE A 392
GLY A 390
ALA A 391
LEU A 989
 None
 0.93A 1eqhB-4k0eA:
undetectable		 1eqhB-4k0eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Sanguibacter
keddieii) 		PF13377
(Peripla_BP_3) 		5 VAL A 278
GLY A 262
ALA A 263
SER A 266
LEU A 267
 None
 0.98A 1eqhB-4kmrA:
1.2		 1eqhB-4kmrA:
18.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 VAL A 117
ARG A 121
VAL A 350
TYR A 356
LEU A 360
TYR A 386
TRP A 388
GLY A 527
ALA A 528
SER A 531
LEU A 532
 BOG  A 604 (-3.9A)
BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.8A)
None
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.32A 1eqhB-4ph9A:
59.5		 1eqhB-4ph9A:
63.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00106
(adh_short) 		5 VAL A  32
LEU A  49
GLY A  12
ALA A  13
LEU A  34
 None
 1.00A 1eqhB-4pn3A:
undetectable		 1eqhB-4pn3A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 VAL B 442
VAL B 577
LEU B 348
GLY B 464
LEU B 483
 None
 1.04A 1eqhB-4qiwB:
0.8		 1eqhB-4qiwB:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A  81
LEU A  96
GLY A 111
ALA A 110
SER A 170
 None
 0.95A 1eqhB-4rjkA:
undetectable		 1eqhB-4rjkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN

(Chaetomium
thermophilum) 		PF05783
(DLIC) 		5 VAL A 228
LEU A 156
GLY A 265
ALA A 266
LEU A 226
 None
 0.98A 1eqhB-4w7gA:
undetectable		 1eqhB-4w7gA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		5 LEU A 121
TYR A  93
ALA A 252
SER A 270
LEU A 269
 None
 1.03A 1eqhB-4wb0A:
undetectable		 1eqhB-4wb0A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		6 VAL A  52
LEU A  67
ILE A  63
ALA A  85
SER A 109
LEU A 108
 None
 1.16A 1eqhB-4wwyA:
undetectable		 1eqhB-4wwyA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		5 LEU A  72
ILE A 207
GLY A 205
ALA A 206
LEU A 194
 None
 0.98A 1eqhB-4yj1A:
undetectable		 1eqhB-4yj1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a33 RNA2 POLYPROTEIN

(Cowpea mosaic
virus) 		PF02248
(Como_SCP) 		5 VAL A 161
LEU A  74
ILE A  39
GLY A  37
LEU A  34
 None
 0.98A 1eqhB-5a33A:
undetectable		 1eqhB-5a33A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		5 VAL A 241
LEU A 207
GLY A 184
ALA A 182
LEU A 166
 None
 1.01A 1eqhB-5bptA:
undetectable		 1eqhB-5bptA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0u ALKYLMERCURY LYASE

(Escherichia
coli) 		PF03243
(MerB)
PF12324
(HTH_15) 		5 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.90A 1eqhB-5c0uA:
undetectable		 1eqhB-5c0uA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 VAL A  81
TRP A  10
ILE A  42
ALA A  18
LEU A  93
 None
 1.04A 1eqhB-5cnxA:
undetectable		 1eqhB-5cnxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dus ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01661
(Macro) 		5 VAL A 158
LEU A 162
GLY A 128
ALA A 127
LEU A 124
 None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.9A)
None
 0.87A 1eqhB-5dusA:
undetectable		 1eqhB-5dusA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		6 VAL A 129
LEU A 103
ILE A 111
GLY A  76
ALA A  75
LEU A  71
 None
 1.46A 1eqhB-5e72A:
undetectable		 1eqhB-5e72A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Hirschia
baltica) 		PF00160
(Pro_isomerase) 		5 TYR A  58
LEU A 211
ILE A  49
GLY A 187
LEU A 171
 None
 0.95A 1eqhB-5ex2A:
undetectable		 1eqhB-5ex2A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		5 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 0.85A 1eqhB-5f4zA:
undetectable		 1eqhB-5f4zA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		5 VAL A 292
LEU A 290
ILE A 362
GLY A 364
SER A 340
 None
 1.05A 1eqhB-5gkqA:
undetectable		 1eqhB-5gkqA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella ovis) 		PF13561
(adh_short_C2) 		5 VAL A  94
ILE A  30
GLY A  33
ALA A  34
LEU A  12
 None
 0.85A 1eqhB-5ha5A:
undetectable		 1eqhB-5ha5A:
17.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.64A 1eqhB-5ikrA:
59.4		 1eqhB-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j47 LARGE T ANTIGEN

(Human
polyomavirus 2) 		PF06431
(Polyoma_lg_T_C) 		5 VAL A 534
VAL A 527
LEU A 424
GLY A 491
LEU A 538
 None
 0.99A 1eqhB-5j47A:
undetectable		 1eqhB-5j47A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		5 VAL A 174
LEU A 594
ILE A 191
GLY A 193
ALA A 192
 None
 0.83A 1eqhB-5jxrA:
0.6		 1eqhB-5jxrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb8 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		5 LEU A  93
GLY A  55
ALA A  56
SER A  59
LEU A  60
 None
 0.80A 1eqhB-5lb8A:
undetectable		 1eqhB-5lb8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 5 VAL A 285
ILE A  49
GLY A  26
ALA A  25
LEU A 287
 None
None
FAD  A 601 (-3.5A)
None
None
 0.85A 1eqhB-5nitA:
undetectable		 1eqhB-5nitA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo NITROGEN REGULATORY
PROTEIN P-II 1

(Azospirillum
brasilense) 		no annotation 5 VAL B  63
VAL B  16
LEU B  20
ILE B  91
ALA B   6
 ADP  B 201 (-4.0A)
None
None
None
None
 0.93A 1eqhB-5ovoB:
undetectable		 1eqhB-5ovoB:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syn ACYL-PROTEIN
THIOESTERASE 2

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		5 VAL A 220
VAL A  27
LEU A  44
GLY A 141
LEU A 224
 None
 0.98A 1eqhB-5synA:
undetectable		 1eqhB-5synA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 VAL A 309
ILE A 331
GLY A 284
ALA A 283
LEU A 279
 None
 0.94A 1eqhB-5wy3A:
undetectable		 1eqhB-5wy3A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF04212
(MIT) 		6 VAL A 186
LEU A 273
ILE A 296
GLY A 140
ALA A 141
LEU A 145
 None
 1.32A 1eqhB-5xmiA:
undetectable		 1eqhB-5xmiA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezo TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Homo sapiens) 		no annotation 5 VAL A 152
LEU A 168
ILE A 194
GLY A 196
SER A 131
 None
 0.91A 1eqhB-6ezoA:
1.2		 1eqhB-6ezoA:
9.85