SIMILAR PATTERNS OF AMINO ACIDS FOR 1EQG_B_IBPB1701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au8 CATHEPSIN G

(Homo sapiens) 		PF00089
(Trypsin) 		6 VAL A  52
LEU A  68
ILE A  64
ALA A  85
SER A 109
LEU A 108
 None
 1.02A 1eqgB-1au8A:
0.0		 1eqgB-1au8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 TYR A 366
ILE A  88
ALA A  92
SER A  95
LEU A  96
 CAA  A 384 (-4.1A)
None
CAA  A 384 ( 4.2A)
None
CAA  A 384 (-4.7A)
 1.10A 1eqgB-1bucA:
0.2		 1eqgB-1bucA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjw PROTEIN (SEROTONIN
N-ACETYLTRANSFERASE)

(Ovis aries) 		PF00583
(Acetyltransf_1) 		6 VAL A  48
SER A  81
LEU A  74
ILE A  94
ALA A 123
LEU A  65
 None
None
None
None
COT  A 400 (-4.1A)
None
 1.14A 1eqgB-1cjwA:
0.0		 1eqgB-1cjwA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ctt CYTIDINE DEAMINASE

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF08211
(dCMP_cyt_deam_2) 		5 SER A 106
LEU A 249
ILE A 108
ALA A 111
SER A 114
 None
 1.15A 1eqgB-1cttA:
0.0		 1eqgB-1cttA:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 VAL A 116
ARG A 120
VAL A 349
SER A 353
TYR A 355
LEU A 359
TYR A 385
ILE A 523
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 (-3.4A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.36A 1eqgB-1ebvA:
63.6		 1eqgB-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 VAL A  52
LEU B  67
ILE B  63
ALA B  85
SER B 109
LEU B 108
 None
 1.16A 1eqgB-1eptA:
undetectable		 1eqgB-1eptA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpj GLUTAMYL-TRNA
REDUCTASE

(Methanopyrus
kandleri) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		5 VAL A  88
LEU A  45
ILE A 131
ALA A 130
LEU A  85
 None
 1.14A 1eqgB-1gpjA:
0.0		 1eqgB-1gpjA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		6 VAL A  52
LEU A  67
ILE A  63
ALA A  85
SER A 109
LEU A 108
 None
 1.18A 1eqgB-1h4wA:
0.0		 1eqgB-1h4wA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 VAL A 235
LEU A 226
ILE A 193
ALA A 215
LEU A 237
 None
 1.01A 1eqgB-1h6uA:
undetectable		 1eqgB-1h6uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 VAL E  52
LEU E  67
ILE E  63
ALA E  85
SER E 109
LEU E 108
 None
 1.24A 1eqgB-1h9hE:
undetectable		 1eqgB-1h9hE:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwu PII PROTEIN

(Herbaspirillum
seropedicae) 		PF00543
(P-II) 		5 VAL A  63
VAL A  16
LEU A  20
ILE A  91
ALA A   6
 None
 1.04A 1eqgB-1hwuA:
undetectable		 1eqgB-1hwuA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ib1 SEROTONIN
N-ACETYLTRANSFERASE

(Ovis aries) 		PF00583
(Acetyltransf_1) 		5 VAL E  48
SER E  81
LEU E  74
ILE E  94
ALA E 123
 None
None
None
None
COT  E 401 (-4.1A)
 0.99A 1eqgB-1ib1E:
undetectable		 1eqgB-1ib1E:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		6 VAL T  52
LEU T  68
ILE T  63
ALA T  85
SER T 109
LEU T 108
 None
 1.16A 1eqgB-1j17T:
undetectable		 1eqgB-1j17T:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.86A 1eqgB-1jy1A:
undetectable		 1eqgB-1jy1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lki LEUKEMIA INHIBITORY
FACTOR

(Mus musculus) 		PF01291
(LIF_OSM) 		5 LEU A  94
ILE A 173
ALA A  37
SER A  36
LEU A  40
 None
 1.08A 1eqgB-1lkiA:
undetectable		 1eqgB-1lkiA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0w GLUTATHIONE
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		5 VAL A 152
SER A 462
LEU A 195
ILE A 445
SER A 158
 3GC  A 501 (-4.2A)
None
None
None
None
 1.05A 1eqgB-1m0wA:
undetectable		 1eqgB-1m0wA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		5 VAL A 223
VAL A 214
LEU A 216
ILE A 166
LEU A 225
 None
 1.02A 1eqgB-1qcxA:
undetectable		 1eqgB-1qcxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdf THIOREDOXIN
REDUCTASE

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		5 VAL A  49
LEU A  59
ILE A 296
ALA A 295
LEU A  43
 FAD  A 500 (-3.4A)
None
None
FAD  A 500 (-3.6A)
FAD  A 500 (-3.3A)
 1.13A 1eqgB-1tdfA:
undetectable		 1eqgB-1tdfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhb TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 VAL A  52
LEU A  67
ILE A  63
ALA A  85
SER A 109
LEU A 108
 None
 1.23A 1eqgB-1uhbA:
undetectable		 1eqgB-1uhbA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl1 6-PHOSPHOGLUCONOLACT
ONASE

(Thermotoga
maritima) 		PF01182
(Glucosamine_iso) 		5 VAL A 208
VAL A  38
SER A  67
LEU A 131
ALA A 174
 None
 1.02A 1eqgB-1vl1A:
undetectable		 1eqgB-1vl1A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		5 VAL A 494
VAL A 372
LEU A 375
ILE A 614
LEU A 492
 None
 0.99A 1eqgB-1w7cA:
undetectable		 1eqgB-1w7cA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		5 VAL A 494
VAL A 372
LEU A 375
TYR A 720
LEU A 492
 None
 1.03A 1eqgB-1w7cA:
undetectable		 1eqgB-1w7cA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 VAL B 288
SER B 249
ILE B 247
ALA B 280
LEU B 284
 None
 1.16A 1eqgB-1w85B:
undetectable		 1eqgB-1w85B:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 VAL A 306
SER A 298
ILE A 222
ALA A 225
LEU A 227
 None
 1.16A 1eqgB-1yq2A:
undetectable		 1eqgB-1yq2A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 VAL A 240
LEU A 256
ALA A 267
SER A 269
LEU A 270
 None
 1.14A 1eqgB-1zczA:
undetectable		 1eqgB-1zczA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Homo sapiens) 		PF01424
(R3H)
PF04857
(CAF1) 		5 VAL A 284
LEU A 322
ILE A 274
ALA A 278
SER A 280
 None
 0.97A 1eqgB-2a1rA:
undetectable		 1eqgB-2a1rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 VAL A  42
LEU A  34
ALA A  88
SER A  91
LEU A  92
 None
 1.06A 1eqgB-2d3lA:
undetectable		 1eqgB-2d3lA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01937
(DUF89) 		5 LEU A 222
ILE A  49
ALA A  53
SER A  55
LEU A  56
 None
None
None
None
EDO  A 289 ( 4.2A)
 1.13A 1eqgB-2g8lA:
undetectable		 1eqgB-2g8lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs8 MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Streptococcus
pyogenes) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 VAL A  90
SER A  49
ILE A   6
ALA A 117
LEU A 114
 None
 1.14A 1eqgB-2gs8A:
undetectable		 1eqgB-2gs8A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwf RING FINGER PROTEIN
41

(Homo sapiens) 		PF08941
(USP8_interact) 		5 VAL B 287
LEU B 233
ILE B 199
SER B 205
LEU B 206
 None
 0.86A 1eqgB-2gwfB:
undetectable		 1eqgB-2gwfB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		5 VAL A 195
LEU A 196
ILE A 156
ALA A 161
LEU A 165
 None
 1.17A 1eqgB-2ibdA:
0.6		 1eqgB-2ibdA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3n TUSP1

(Nephila
antipodiana) 		PF12042
(RP1-2) 		5 SER A 127
ILE A  56
ALA A  60
SER A  63
LEU A  64
 None
 1.07A 1eqgB-2k3nA:
undetectable		 1eqgB-2k3nA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 264
VAL A 254
SER A 255
LEU A 251
ALA A 239
 None
 1.10A 1eqgB-2nqlA:
undetectable		 1eqgB-2nqlA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsv UNCHARACTERIZED
PROTEIN

(Porphyromonas
gingivalis) 		PF07610
(DUF1573) 		5 VAL A  27
ARG A  61
VAL A  39
LEU A  84
LEU A  63
 None
 1.15A 1eqgB-2qsvA:
undetectable		 1eqgB-2qsvA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4y PILP PROTEIN

(Pseudomonas
aeruginosa) 		PF04351
(PilP) 		5 VAL A 118
VAL A 150
LEU A 133
ILE A 143
LEU A 168
 None
 1.16A 1eqgB-2y4yA:
undetectable		 1eqgB-2y4yA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA

(Escherichia
coli) 		PF13580
(SIS_2) 		5 VAL A 140
LEU A 114
ILE A  27
ALA A  31
LEU A  34
 None
 0.96A 1eqgB-2yvaA:
0.9		 1eqgB-2yvaA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 VAL A 592
SER A 596
LEU A 559
TYR A 570
LEU A 610
 None
 1.13A 1eqgB-2zxhA:
undetectable		 1eqgB-2zxhA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE

(Streptomyces
ansochromogenes) 		PF03060
(NMO) 		5 VAL A 212
VAL A 125
SER A 127
ALA A 168
LEU A   5
 None
 1.16A 1eqgB-3bw2A:
undetectable		 1eqgB-3bw2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1v DNA POLYMERASE III
SUBUNIT BETA

(Escherichia
coli) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 VAL A 321
LEU A 325
ILE A 292
ALA A 270
SER A 274
 None
 0.96A 1eqgB-3f1vA:
undetectable		 1eqgB-3f1vA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj1 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Ruegeria
pomeroyi) 		PF01380
(SIS) 		5 VAL A  48
VAL A 134
SER A 135
LEU A 131
ALA A 113
 None
 1.15A 1eqgB-3fj1A:
1.1		 1eqgB-3fj1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 VAL A 301
ILE A 307
ALA A 385
SER A 388
LEU A 389
 None
 0.97A 1eqgB-3hz6A:
undetectable		 1eqgB-3hz6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i10 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Bacteroides
thetaiotaomicron) 		PF03009
(GDPD)
PF16387
(DUF4996) 		5 VAL A 168
LEU A 145
ILE A 141
ALA A 137
LEU A 134
 None
 1.16A 1eqgB-3i10A:
undetectable		 1eqgB-3i10A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 VAL A 399
LEU A 396
ILE A 417
ALA A 421
LEU A 424
 None
 1.08A 1eqgB-3ibjA:
undetectable		 1eqgB-3ibjA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jab GAFB DOMAIN OF
PHOSPHODIESTERASE 2A

(Bos taurus) 		PF01590
(GAF) 		5 VAL B 399
LEU B 396
ILE B 417
ALA B 421
LEU B 424
 None
 1.06A 1eqgB-3jabB:
undetectable		 1eqgB-3jabB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		5 VAL A  85
LEU A 102
ILE A 144
ALA A 139
LEU A 135
 None
 1.13A 1eqgB-3k8kA:
undetectable		 1eqgB-3k8kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khn MOTB PROTEIN,
PUTATIVE

(Desulfovibrio
vulgaris) 		PF00691
(OmpA) 		5 VAL A 116
VAL A  49
SER A  51
ALA A  66
LEU A  70
 None
 1.10A 1eqgB-3khnA:
undetectable		 1eqgB-3khnA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf0 NITROGEN REGULATORY
PROTEIN P-II

(Mycobacterium
tuberculosis) 		PF00543
(P-II) 		5 VAL A  63
VAL A  16
SER A  76
LEU A  20
ALA A   6
 None
 1.02A 1eqgB-3lf0A:
undetectable		 1eqgB-3lf0A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 VAL A 157
LEU A  22
ILE A 139
SER A 143
LEU A 146
 None
 1.14A 1eqgB-3lkdA:
0.0		 1eqgB-3lkdA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdp CYCLIC
NUCLEOTIDE-BINDING
DOMAIN (CNMP-BD)
PROTEIN

(Geobacter
metallireducens) 		PF00027
(cNMP_binding) 		5 VAL A  77
ILE A  39
ALA A  98
SER A  96
LEU A  59
 None
None
None
SIN  A 142 (-3.2A)
SIN  A 142 (-4.5A)
 1.08A 1eqgB-3mdpA:
undetectable		 1eqgB-3mdpA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwy URIDYLATE KINASE

(Mycobacterium
tuberculosis) 		PF00696
(AA_kinase) 		5 VAL A  73
VAL A  57
LEU A 111
ILE A 246
LEU A  37
 None
 1.09A 1eqgB-3nwyA:
undetectable		 1eqgB-3nwyA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5t PII-LIKE PROTEIN PZ

(Azospirillum
brasilense) 		PF00543
(P-II) 		5 VAL B  63
VAL B  16
LEU B  20
ILE B  91
ALA B   6
 ADP  B 113 (-4.1A)
None
None
None
None
 0.97A 1eqgB-3o5tB:
undetectable		 1eqgB-3o5tB:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omb EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		5 VAL A 422
VAL A  43
ILE A 355
ALA A 369
LEU A 372
 None
 1.14A 1eqgB-3ombA:
undetectable		 1eqgB-3ombA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		5 VAL A 248
VAL A 220
LEU A 260
ILE A 353
LEU A 389
 None
 1.03A 1eqgB-3p24A:
undetectable		 1eqgB-3p24A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9z NITROGEN REGULATORY
PROTEIN P-II
(GLNB-3)

(Archaeoglobus
fulgidus) 		PF00543
(P-II) 		5 VAL A  63
VAL A  16
LEU A  20
ILE A  91
ALA A   6
 None
 1.08A 1eqgB-3t9zA:
undetectable		 1eqgB-3t9zA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 VAL A 162
VAL A 174
LEU A 170
ILE A 409
ALA A 385
 None
 1.06A 1eqgB-3vf1A:
undetectable		 1eqgB-3vf1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		5 VAL A  64
ARG A  94
LEU A  75
ALA A 100
LEU A  91
 None
 1.08A 1eqgB-3vzbA:
undetectable		 1eqgB-3vzbA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		5 SER A 376
TYR A 133
ILE A 453
ALA A 457
SER A 460
 None
 1.07A 1eqgB-4b8sA:
undetectable		 1eqgB-4b8sA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN

(Escherichia
coli) 		PF05171
(HemS) 		5 VAL A 242
LEU A 230
ILE A 311
ALA A  71
LEU A 276
 None
 1.16A 1eqgB-4cdpA:
undetectable		 1eqgB-4cdpA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL38

(Sus scrofa) 		no annotation 5 VAL b 204
LEU b 216
TYR b 154
ALA b 317
LEU b 173
 None
 1.16A 1eqgB-4ce4b:
undetectable		 1eqgB-4ce4b:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7e L-LYS MONOOXYGENASE

(Nocardia
farcinica) 		PF13434
(K_oxygenase) 		5 VAL A 332
ILE A 233
ALA A 209
SER A 207
LEU A 330
 None
 0.95A 1eqgB-4d7eA:
undetectable		 1eqgB-4d7eA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2o ALPHA-AMYLASE

(Geobacillus
thermoleovorans) 		PF00128
(Alpha-amylase) 		5 VAL A 136
VAL A  73
LEU A 125
ILE A  80
LEU A  90
 None
 1.11A 1eqgB-4e2oA:
undetectable		 1eqgB-4e2oA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ed9 CAIB/BAIF FAMILY
PROTEIN

(Brucella suis) 		PF02515
(CoA_transf_3) 		5 VAL A  96
LEU A  27
ILE A 200
ALA A 187
LEU A 188
 None
 1.13A 1eqgB-4ed9A:
undetectable		 1eqgB-4ed9A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		5 VAL A 366
LEU A 182
ILE A 170
ALA A 171
LEU A 362
 None
 1.12A 1eqgB-4ei8A:
undetectable		 1eqgB-4ei8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fho INTERNALIN C2

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 VAL A 235
LEU A 226
ILE A 193
ALA A 215
LEU A 237
 None
 1.02A 1eqgB-4fhoA:
undetectable		 1eqgB-4fhoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		5 VAL C 439
VAL C 372
ILE C 280
ALA C 285
LEU C 443
 None
 1.14A 1eqgB-4j16C:
undetectable		 1eqgB-4j16C:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		5 TYR A 306
ILE A 327
ALA A 332
SER A 335
LEU A 336
 None
 1.14A 1eqgB-4j5uA:
undetectable		 1eqgB-4j5uA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		6 VAL A 479
TYR A 411
LEU A 420
ILE A 424
ALA A 337
LEU A 384
 None
 1.28A 1eqgB-4jcmA:
undetectable		 1eqgB-4jcmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 5 VAL A 153
LEU A 214
ALA A 141
SER A 145
LEU A 142
 None
 1.16A 1eqgB-4jw1A:
undetectable		 1eqgB-4jw1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxt REGULATION OF
NUCLEAR PRE-MRNA
DOMAIN-CONTAINING
PROTEIN 1A

(Homo sapiens) 		PF04818
(CTD_bind) 		5 TYR A 117
LEU A 125
ILE A  67
ALA A  63
LEU A  60
 UNX  A 202 ( 4.9A)
None
None
None
None
 1.02A 1eqgB-4jxtA:
undetectable		 1eqgB-4jxtA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 532
VAL A 500
LEU A 515
ILE A 472
ALA A 524
 None
CSO  A 519 ( 4.6A)
None
HG  A 909 (-3.6A)
None
 1.09A 1eqgB-4nhoA:
undetectable		 1eqgB-4nhoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 VAL B 418
VAL B 432
LEU B 408
ILE B 379
ALA B 390
 None
None
None
ACP  B 801 (-4.0A)
ACP  B 801 (-3.2A)
 1.08A 1eqgB-4oavB:
undetectable		 1eqgB-4oavB:
22.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 VAL A 117
ARG A 121
VAL A 350
SER A 354
TYR A 356
LEU A 360
TYR A 386
ALA A 528
SER A 531
LEU A 532
 BOG  A 604 (-3.9A)
BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
None
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.8A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.50A 1eqgB-4ph9A:
59.3		 1eqgB-4ph9A:
63.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		5 VAL A  38
ILE A 221
ALA A 225
SER A 227
LEU A 228
 None
 1.00A 1eqgB-4ql6A:
undetectable		 1eqgB-4ql6A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rni MOTILITY REGULATOR

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 LEU A 169
ILE A 203
ALA A 207
SER A 209
LEU A 210
 None
 1.17A 1eqgB-4rniA:
undetectable		 1eqgB-4rniA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvo MALATE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  70
LEU A  42
ILE A  38
ALA A  27
LEU A  59
 None
 1.11A 1eqgB-4tvoA:
undetectable		 1eqgB-4tvoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 LEU A 204
ILE A 269
ALA A 191
SER A 194
LEU A 195
 None
 1.08A 1eqgB-4us4A:
0.0		 1eqgB-4us4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		6 VAL A  52
LEU A  67
ILE A  63
ALA A  85
SER A 109
LEU A 108
 None
 1.20A 1eqgB-4wwyA:
undetectable		 1eqgB-4wwyA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		5 SER A 349
LEU A  73
ILE A 351
ALA A 354
SER A 356
 None
None
CLR  A 604 (-4.3A)
None
CL  A 603 (-2.9A)
 1.15A 1eqgB-4xnuA:
undetectable		 1eqgB-4xnuA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xze NUCLEOPROTEIN

(Hazara
orthonairovirus) 		PF02477
(Nairo_nucleo) 		5 VAL A 330
SER A 313
TYR A 112
ALA A 320
LEU A 362
 None
 1.14A 1eqgB-4xzeA:
undetectable		 1eqgB-4xzeA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 5 VAL A 590
VAL A1030
LEU A 624
ILE A 601
LEU A1045
 None
 1.17A 1eqgB-4yhcA:
undetectable		 1eqgB-4yhcA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF02826
(2-Hacid_dh_C) 		5 SER A  69
LEU A  77
ILE A  49
ALA A  48
LEU A  58
 None
 1.13A 1eqgB-4zqbA:
undetectable		 1eqgB-4zqbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyl RPHYB PROTEIN

(Rhodopseudomonas
palustris) 		PF00072
(Response_reg) 		5 VAL A  67
VAL A  81
LEU A  85
ALA A  13
LEU A  69
 None
 1.14A 1eqgB-4zylA:
undetectable		 1eqgB-4zylA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2p SYNTENIN-1

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 VAL A 140
VAL A 117
ILE A 127
ALA A 149
LEU A 154
 None
 1.17A 1eqgB-5a2pA:
undetectable		 1eqgB-5a2pA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8z NEUTROPHIL ELASTASE

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  59
VAL A  52
LEU A 106
ILE A 212
LEU A  33
 None
 1.06A 1eqgB-5a8zA:
undetectable		 1eqgB-5a8zA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0u ALKYLMERCURY LYASE

(Escherichia
coli) 		PF03243
(MerB)
PF12324
(HTH_15) 		5 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.90A 1eqgB-5c0uA:
undetectable		 1eqgB-5c0uA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		5 VAL A 362
VAL A 442
LEU A 385
ILE A 348
LEU A 367
 CME  A 352 ( 4.0A)
None
None
None
None
 1.03A 1eqgB-5d8gA:
undetectable		 1eqgB-5d8gA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 VAL h 420
LEU h 507
ILE h 439
ALA h 443
LEU h 446
 None
 1.03A 1eqgB-5gw5h:
0.6		 1eqgB-5gw5h:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 VAL A 116
ARG A 120
VAL A 349
SER A 353
TYR A 355
LEU A 359
TYR A 385
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.35A 1eqgB-5ikrA:
59.3		 1eqgB-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		5 VAL A 199
VAL A  73
LEU A 178
SER A  77
LEU A 214
 None
 1.04A 1eqgB-5mq6A:
undetectable		 1eqgB-5mq6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npy FLAGELLAR BASAL BODY
PROTEIN

(Helicobacter
pylori) 		no annotation 5 VAL A 197
VAL A 400
SER A 375
LEU A 448
LEU A 199
 None
 1.09A 1eqgB-5npyA:
undetectable		 1eqgB-5npyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		5 VAL A 283
TYR A 516
LEU A 517
ILE A 491
LEU A 285
 None
 1.11A 1eqgB-5ntfA:
undetectable		 1eqgB-5ntfA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		5 VAL A 250
SER A 216
ALA A 225
SER A 223
LEU A 195
 None
 1.14A 1eqgB-5oe5A:
undetectable		 1eqgB-5oe5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo NITROGEN REGULATORY
PROTEIN P-II 1

(Azospirillum
brasilense) 		no annotation 5 VAL B  63
VAL B  16
LEU B  20
ILE B  91
ALA B   6
 ADP  B 201 (-4.0A)
None
None
None
None
 0.94A 1eqgB-5ovoB:
undetectable		 1eqgB-5ovoB:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqb 60S RIBOSOMAL
PROTEIN L4-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00573
(Ribosomal_L4) 		5 VAL A 163
VAL A 153
SER A 155
ALA A  12
LEU A 172
 None
 1.06A 1eqgB-5tqbA:
undetectable		 1eqgB-5tqbA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 VAL A 137
ILE A 395
ALA A 398
SER A 401
LEU A 404
 None
SO4  A1209 (-4.5A)
SO4  A1209 ( 3.9A)
None
None
 1.16A 1eqgB-5u09A:
undetectable		 1eqgB-5u09A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf4 UNCHARACTERIZED
PROTEIN

(Thermus
aquaticus) 		PF03781
(FGE-sulfatase) 		5 VAL A  32
SER A  83
LEU A  34
ALA A 102
SER A 105
 None
 1.16A 1eqgB-5vf4A:
undetectable		 1eqgB-5vf4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgz 26S PROTEASOME
REGULATORY SUBUNIT
6B
26S PROTEASOME
REGULATORY SUBUNIT 8

(Homo sapiens) 		no annotation 5 SER D 117
LEU C  59
ILE D 115
ALA D 138
LEU C  66
 None
 1.12A 1eqgB-5vgzD:
undetectable		 1eqgB-5vgzD:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpb HISTONE DEACETYLASE
6

(Homo sapiens) 		PF02148
(zf-UBP) 		5 VAL A1190
VAL A1119
LEU A1172
ALA A1194
LEU A1195
 None
 1.07A 1eqgB-5wpbA:
undetectable		 1eqgB-5wpbA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 5 VAL A 131
VAL A 161
LEU A 172
ILE A 140
LEU A 222
 None
 1.12A 1eqgB-5wypA:
undetectable		 1eqgB-5wypA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum) 		no annotation 5 VAL A 232
LEU A 241
TYR A  56
ILE A 184
LEU A 192
 None
 1.12A 1eqgB-5x7uA:
undetectable		 1eqgB-5x7uA:
8.46