SIMILAR PATTERNS OF AMINO ACIDS FOR 1EQG_A_IBPA701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au8 CATHEPSIN G

(Homo sapiens) 		PF00089
(Trypsin) 		6 VAL A  52
LEU A  68
ILE A  64
ALA A  85
SER A 109
LEU A 108
 None
 1.02A 1eqgA-1au8A:
0.0		 1eqgA-1au8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aua PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
SEC14P

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 VAL A 194
VAL A 129
ILE A 182
ALA A 187
SER A 189
 BOG  A   2 (-4.5A)
None
None
None
None
 1.20A 1eqgA-1auaA:
0.0		 1eqgA-1auaA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 TYR A 366
ILE A  88
ALA A  92
SER A  95
LEU A  96
 CAA  A 384 (-4.1A)
None
CAA  A 384 ( 4.2A)
None
CAA  A 384 (-4.7A)
 1.07A 1eqgA-1bucA:
0.3		 1eqgA-1bucA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		5 VAL A1176
ILE A1032
ALA A1020
SER A1019
LEU A1023
 None
 1.18A 1eqgA-1c0iA:
0.0		 1eqgA-1c0iA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpc C-PHYCOCYANIN (ALPHA
SUBUNIT)

(Microchaete
diplosiphon) 		PF00502
(Phycobilisome) 		5 TYR A  91
LEU A 133
ILE A 115
ALA A 172
SER A 174
 None
 1.20A 1eqgA-1cpcA:
undetectable		 1eqgA-1cpcA:
15.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
ILE A 523
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
SCL  A 700 (-3.4A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.40A 1eqgA-1ebvA:
63.6		 1eqgA-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 VAL A  52
LEU B  67
ILE B  63
ALA B  85
SER B 109
LEU B 108
 None
 1.17A 1eqgA-1eptA:
undetectable		 1eqgA-1eptA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 VAL A  72
LEU A  62
ILE A  52
ALA A  32
LEU A   9
 None
 1.18A 1eqgA-1ff9A:
0.0		 1eqgA-1ff9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpj GLUTAMYL-TRNA
REDUCTASE

(Methanopyrus
kandleri) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		5 VAL A  88
LEU A  45
ILE A 131
ALA A 130
LEU A  85
 None
 1.12A 1eqgA-1gpjA:
0.0		 1eqgA-1gpjA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		6 VAL A  52
LEU A  67
ILE A  63
ALA A  85
SER A 109
LEU A 108
 None
 1.17A 1eqgA-1h4wA:
undetectable		 1eqgA-1h4wA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 VAL A 235
LEU A 226
ILE A 193
ALA A 215
LEU A 237
 None
 0.99A 1eqgA-1h6uA:
undetectable		 1eqgA-1h6uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 VAL E  52
LEU E  67
ILE E  63
ALA E  85
SER E 109
LEU E 108
 None
 1.24A 1eqgA-1h9hE:
undetectable		 1eqgA-1h9hE:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg2 CLATHRIN ASSEMBLY
PROTEIN SHORT FORM

(Rattus
norvegicus) 		PF07651
(ANTH) 		5 LEU A  45
ILE A  56
ALA A  60
SER A  62
LEU A  63
 None
 1.16A 1eqgA-1hg2A:
undetectable		 1eqgA-1hg2A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwu PII PROTEIN

(Herbaspirillum
seropedicae) 		PF00543
(P-II) 		5 VAL A  63
VAL A  16
LEU A  20
ILE A  91
ALA A   6
 None
 1.02A 1eqgA-1hwuA:
undetectable		 1eqgA-1hwuA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		6 VAL T  52
LEU T  68
ILE T  63
ALA T  85
SER T 109
LEU T 108
 None
 1.16A 1eqgA-1j17T:
undetectable		 1eqgA-1j17T:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.85A 1eqgA-1jy1A:
undetectable		 1eqgA-1jy1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 VAL A 172
VAL A 184
LEU A 168
ALA A 215
LEU A 216
 None
 1.19A 1eqgA-1k1bA:
undetectable		 1eqgA-1k1bA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lki LEUKEMIA INHIBITORY
FACTOR

(Mus musculus) 		PF01291
(LIF_OSM) 		5 LEU A  94
ILE A 173
ALA A  37
SER A  36
LEU A  40
 None
 1.10A 1eqgA-1lkiA:
undetectable		 1eqgA-1lkiA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		5 VAL A 223
VAL A 214
LEU A 216
ILE A 166
LEU A 225
 None
 0.99A 1eqgA-1qcxA:
undetectable		 1eqgA-1qcxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 VAL A  54
LEU A  71
ILE A 122
ALA A 117
LEU A 113
 None
 1.18A 1eqgA-1qhoA:
undetectable		 1eqgA-1qhoA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdf THIOREDOXIN
REDUCTASE

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		5 VAL A  49
LEU A  59
ILE A 296
ALA A 295
LEU A  43
 FAD  A 500 (-3.4A)
None
None
FAD  A 500 (-3.6A)
FAD  A 500 (-3.3A)
 1.14A 1eqgA-1tdfA:
undetectable		 1eqgA-1tdfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhb TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 VAL A  52
LEU A  67
ILE A  63
ALA A  85
SER A 109
LEU A 108
 None
 1.23A 1eqgA-1uhbA:
undetectable		 1eqgA-1uhbA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Toxoplasma
gondii) 		no annotation 5 VAL D 108
LEU D 151
ILE D 135
ALA D 176
LEU D 180
 None
 1.17A 1eqgA-1upfD:
0.0		 1eqgA-1upfD:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		5 VAL A 128
VAL A  66
LEU A  43
ALA A  94
LEU A  97
 None
None
None
SAM  A 302 (-3.3A)
None
 1.21A 1eqgA-1ve3A:
undetectable		 1eqgA-1ve3A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		5 VAL A 494
VAL A 372
LEU A 375
ILE A 614
LEU A 492
 None
 0.98A 1eqgA-1w7cA:
undetectable		 1eqgA-1w7cA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptococcus
pneumoniae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 VAL A 108
LEU A 112
ILE A 131
ALA A  69
LEU A  70
 None
None
None
None
IOD  A 471 ( 4.6A)
 1.15A 1eqgA-1xp4A:
undetectable		 1eqgA-1xp4A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 VAL A 240
LEU A 256
ALA A 267
SER A 269
LEU A 270
 None
 1.13A 1eqgA-1zczA:
undetectable		 1eqgA-1zczA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Homo sapiens) 		PF01424
(R3H)
PF04857
(CAF1) 		5 VAL A 284
LEU A 322
ILE A 274
ALA A 278
SER A 280
 None
 0.95A 1eqgA-2a1rA:
undetectable		 1eqgA-2a1rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 VAL A 430
TYR A 226
LEU A 335
ILE A 352
ALA A 355
 None
 1.15A 1eqgA-2bf4A:
undetectable		 1eqgA-2bf4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 VAL A  42
LEU A  34
ALA A  88
SER A  91
LEU A  92
 None
 1.05A 1eqgA-2d3lA:
undetectable		 1eqgA-2d3lA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg1 NITROGEN REGULATORY
PROTEIN P-II

(Aquifex
aeolicus) 		PF00543
(P-II) 		5 VAL A  63
VAL A  16
LEU A  20
ILE A  91
ALA A   6
 None
 1.10A 1eqgA-2eg1A:
undetectable		 1eqgA-2eg1A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 VAL A 254
LEU A 282
ILE A 295
ALA A 300
LEU A 304
 None
 1.17A 1eqgA-2f3oA:
undetectable		 1eqgA-2f3oA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01937
(DUF89) 		5 LEU A 222
ILE A  49
ALA A  53
SER A  55
LEU A  56
 None
None
None
None
EDO  A 289 ( 4.2A)
 1.13A 1eqgA-2g8lA:
undetectable		 1eqgA-2g8lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwf RING FINGER PROTEIN
41

(Homo sapiens) 		PF08941
(USP8_interact) 		5 VAL B 287
LEU B 233
ILE B 199
SER B 205
LEU B 206
 None
 0.85A 1eqgA-2gwfB:
undetectable		 1eqgA-2gwfB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN

(Bacillus
megaterium) 		PF13377
(Peripla_BP_3) 		5 VAL G 142
VAL G 127
ILE G  66
SER G 147
LEU G 144
 None
 1.19A 1eqgA-2nzuG:
undetectable		 1eqgA-2nzuG:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		5 VAL A 201
VAL A 390
ALA A  83
SER A  87
LEU A  84
 None
 1.21A 1eqgA-2q8nA:
undetectable		 1eqgA-2q8nA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsd UNCHARACTERIZED
CONSERVED PROTEIN

(Idiomarina
loihiensis) 		PF07566
(DUF1543) 		5 VAL A  59
VAL A 106
LEU A 167
ILE A  69
LEU A  10
 None
 1.15A 1eqgA-2qsdA:
undetectable		 1eqgA-2qsdA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4y PILP PROTEIN

(Pseudomonas
aeruginosa) 		PF04351
(PilP) 		5 VAL A 118
VAL A 150
LEU A 133
ILE A 143
LEU A 168
 None
 1.14A 1eqgA-2y4yA:
undetectable		 1eqgA-2y4yA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA

(Escherichia
coli) 		PF13580
(SIS_2) 		5 VAL A 140
LEU A 114
ILE A  27
ALA A  31
LEU A  34
 None
 0.94A 1eqgA-2yvaA:
0.3		 1eqgA-2yvaA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 VAL A 716
VAL A 674
ILE A 575
SER A 679
LEU A 680
 None
 1.20A 1eqgA-3ai7A:
0.0		 1eqgA-3ai7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		5 VAL A 277
LEU A 315
ILE A 267
ALA A 271
SER A 273
 None
 0.96A 1eqgA-3d45A:
undetectable		 1eqgA-3d45A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		5 VAL A  36
LEU A  26
ILE A  63
ALA A  60
LEU A  59
 None
 1.20A 1eqgA-3douA:
undetectable		 1eqgA-3douA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1v DNA POLYMERASE III
SUBUNIT BETA

(Escherichia
coli) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 VAL A 321
LEU A 325
ILE A 292
ALA A 270
SER A 274
 None
 0.94A 1eqgA-3f1vA:
undetectable		 1eqgA-3f1vA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 VAL A 301
ILE A 307
ALA A 385
SER A 388
LEU A 389
 None
 0.99A 1eqgA-3hz6A:
undetectable		 1eqgA-3hz6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 VAL A 399
LEU A 396
ILE A 417
ALA A 421
LEU A 424
 None
 1.07A 1eqgA-3ibjA:
undetectable		 1eqgA-3ibjA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		5 VAL A  85
LEU A 102
ILE A 144
ALA A 139
LEU A 135
 None
 1.12A 1eqgA-3k8kA:
undetectable		 1eqgA-3k8kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 VAL A 157
LEU A  22
ILE A 139
SER A 143
LEU A 146
 None
 1.15A 1eqgA-3lkdA:
undetectable		 1eqgA-3lkdA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdp CYCLIC
NUCLEOTIDE-BINDING
DOMAIN (CNMP-BD)
PROTEIN

(Geobacter
metallireducens) 		PF00027
(cNMP_binding) 		5 VAL A  77
ILE A  39
ALA A  98
SER A  96
LEU A  59
 None
None
None
SIN  A 142 (-3.2A)
SIN  A 142 (-4.5A)
 1.06A 1eqgA-3mdpA:
undetectable		 1eqgA-3mdpA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncp NITROGEN REGULATORY
PROTEIN P-II
(GLNB-2)

(Archaeoglobus
fulgidus) 		PF00543
(P-II) 		5 VAL A  16
LEU A  20
ILE A  91
ALA A   6
LEU A  61
 None
 1.19A 1eqgA-3ncpA:
undetectable		 1eqgA-3ncpA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwy URIDYLATE KINASE

(Mycobacterium
tuberculosis) 		PF00696
(AA_kinase) 		5 VAL A  73
VAL A  57
LEU A 111
ILE A 246
LEU A  37
 None
 1.07A 1eqgA-3nwyA:
undetectable		 1eqgA-3nwyA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5t PII-LIKE PROTEIN PZ

(Azospirillum
brasilense) 		PF00543
(P-II) 		5 VAL B  63
VAL B  16
LEU B  20
ILE B  91
ALA B   6
 ADP  B 113 (-4.1A)
None
None
None
None
 0.96A 1eqgA-3o5tB:
undetectable		 1eqgA-3o5tB:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oac GERANYL DIPHOSPHATE
SYNTHASE SMALL
SUBUNIT

(Mentha x
piperita) 		no annotation 5 VAL B 138
LEU B 193
ILE B  69
ALA B  68
LEU B 120
 None
 1.18A 1eqgA-3oacB:
0.7		 1eqgA-3oacB:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omb EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		5 VAL A 422
VAL A  43
ILE A 355
ALA A 369
LEU A 372
 None
 1.12A 1eqgA-3ombA:
undetectable		 1eqgA-3ombA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		5 VAL A 248
VAL A 220
LEU A 260
ILE A 353
LEU A 389
 None
 1.01A 1eqgA-3p24A:
undetectable		 1eqgA-3p24A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		5 VAL B 225
LEU B 217
ILE B 210
SER B 249
LEU B 250
 None
 1.16A 1eqgA-3s4wB:
undetectable		 1eqgA-3s4wB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9z NITROGEN REGULATORY
PROTEIN P-II
(GLNB-3)

(Archaeoglobus
fulgidus) 		PF00543
(P-II) 		5 VAL A  63
VAL A  16
LEU A  20
ILE A  91
ALA A   6
 None
 1.07A 1eqgA-3t9zA:
undetectable		 1eqgA-3t9zA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		5 VAL A 361
LEU A 254
ILE A 223
ALA A 238
LEU A 359
 None
 1.12A 1eqgA-3ut3A:
undetectable		 1eqgA-3ut3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 VAL A 162
VAL A 174
LEU A 170
ILE A 409
ALA A 385
 None
 1.06A 1eqgA-3vf1A:
0.0		 1eqgA-3vf1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN

(Escherichia
coli) 		PF05171
(HemS) 		5 VAL A 242
LEU A 230
ILE A 311
ALA A  71
LEU A 276
 None
 1.17A 1eqgA-4cdpA:
undetectable		 1eqgA-4cdpA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7e L-LYS MONOOXYGENASE

(Nocardia
farcinica) 		PF13434
(K_oxygenase) 		5 VAL A 332
ILE A 233
ALA A 209
SER A 207
LEU A 330
 None
 0.93A 1eqgA-4d7eA:
undetectable		 1eqgA-4d7eA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2o ALPHA-AMYLASE

(Geobacillus
thermoleovorans) 		PF00128
(Alpha-amylase) 		5 VAL A 136
VAL A  73
LEU A 125
ILE A  80
LEU A  90
 None
 1.11A 1eqgA-4e2oA:
undetectable		 1eqgA-4e2oA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		5 VAL A 366
LEU A 182
ILE A 170
ALA A 171
LEU A 362
 None
 1.12A 1eqgA-4ei8A:
undetectable		 1eqgA-4ei8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fho INTERNALIN C2

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 VAL A 235
LEU A 226
ILE A 193
ALA A 215
LEU A 237
 None
 1.00A 1eqgA-4fhoA:
undetectable		 1eqgA-4fhoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA
ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 VAL A 332
LEU A  39
ALA B 308
SER B 312
LEU B 309
 None
None
None
EDO  B 902 (-2.8A)
None
 1.18A 1eqgA-4hdsA:
undetectable		 1eqgA-4hdsA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		5 VAL A 221
LEU A 147
ILE A 214
SER A 164
LEU A 168
 None
 1.18A 1eqgA-4im4A:
undetectable		 1eqgA-4im4A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isb LONG CHAIN FATTY
ACID COA LIGASE
FADD10

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 VAL A  83
LEU A 233
ILE A 175
ALA A 173
LEU A 172
 None
 1.06A 1eqgA-4isbA:
undetectable		 1eqgA-4isbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		5 VAL C 439
VAL C 372
ILE C 280
ALA C 285
LEU C 443
 None
 1.13A 1eqgA-4j16C:
undetectable		 1eqgA-4j16C:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		5 TYR A 306
ILE A 327
ALA A 332
SER A 335
LEU A 336
 None
 1.13A 1eqgA-4j5uA:
undetectable		 1eqgA-4j5uA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		6 VAL A 479
TYR A 411
LEU A 420
ILE A 424
ALA A 337
LEU A 384
 None
 1.31A 1eqgA-4jcmA:
undetectable		 1eqgA-4jcmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 5 VAL A 153
LEU A 214
ALA A 141
SER A 145
LEU A 142
 None
 1.17A 1eqgA-4jw1A:
undetectable		 1eqgA-4jw1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxt REGULATION OF
NUCLEAR PRE-MRNA
DOMAIN-CONTAINING
PROTEIN 1A

(Homo sapiens) 		PF04818
(CTD_bind) 		5 TYR A 117
LEU A 125
ILE A  67
ALA A  63
LEU A  60
 UNX  A 202 ( 4.9A)
None
None
None
None
 1.01A 1eqgA-4jxtA:
undetectable		 1eqgA-4jxtA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krc PHO85 CYCLIN-10

(Saccharomyces
cerevisiae) 		PF08613
(Cyclin) 		5 VAL B 406
LEU B 411
ILE B 335
ALA B 366
LEU B 369
 None
 1.19A 1eqgA-4krcB:
undetectable		 1eqgA-4krcB:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 532
VAL A 500
LEU A 515
ILE A 472
ALA A 524
 None
CSO  A 519 ( 4.6A)
None
HG  A 909 (-3.6A)
None
 1.08A 1eqgA-4nhoA:
undetectable		 1eqgA-4nhoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		5 VAL B 439
VAL B 372
ILE B 280
ALA B 285
LEU B 443
 None
 1.18A 1eqgA-4o9uB:
undetectable		 1eqgA-4o9uB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 VAL B 418
VAL B 432
LEU B 408
ILE B 379
ALA B 390
 None
None
None
ACP  B 801 (-4.0A)
ACP  B 801 (-3.2A)
 1.09A 1eqgA-4oavB:
undetectable		 1eqgA-4oavB:
22.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 VAL A 117
ARG A 121
VAL A 350
TYR A 356
LEU A 360
ALA A 528
SER A 531
LEU A 532
 BOG  A 604 (-3.9A)
BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.55A 1eqgA-4ph9A:
59.2		 1eqgA-4ph9A:
63.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB

(Escherichia
coli) 		PF07244
(POTRA)
PF13360
(PQQ_2) 		5 VAL A1081
LEU A1134
ALA A1109
SER A1126
LEU A1111
 None
 1.19A 1eqgA-4pk1A:
undetectable		 1eqgA-4pk1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 VAL A2781
VAL A2800
ILE A2725
ALA A2721
LEU A2718
 None
 1.12A 1eqgA-4qyrA:
undetectable		 1eqgA-4qyrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rni MOTILITY REGULATOR

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 LEU A 169
ILE A 203
ALA A 207
SER A 209
LEU A 210
 None
 1.14A 1eqgA-4rniA:
undetectable		 1eqgA-4rniA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 LEU A 204
ILE A 269
ALA A 191
SER A 194
LEU A 195
 None
 1.08A 1eqgA-4us4A:
0.0		 1eqgA-4us4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		6 VAL A  52
LEU A  67
ILE A  63
ALA A  85
SER A 109
LEU A 108
 None
 1.20A 1eqgA-4wwyA:
undetectable		 1eqgA-4wwyA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 5 VAL A 590
VAL A1030
LEU A 624
ILE A 601
LEU A1045
 None
 1.17A 1eqgA-4yhcA:
undetectable		 1eqgA-4yhcA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyl RPHYB PROTEIN

(Rhodopseudomonas
palustris) 		PF00072
(Response_reg) 		5 VAL A  67
VAL A  81
LEU A  85
ALA A  13
LEU A  69
 None
 1.14A 1eqgA-4zylA:
undetectable		 1eqgA-4zylA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2p SYNTENIN-1

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 VAL A 140
VAL A 117
ILE A 127
ALA A 149
LEU A 154
 None
 1.13A 1eqgA-5a2pA:
undetectable		 1eqgA-5a2pA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8z NEUTROPHIL ELASTASE

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  59
VAL A  52
LEU A 106
ILE A 212
LEU A  33
 None
 1.05A 1eqgA-5a8zA:
undetectable		 1eqgA-5a8zA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0u ALKYLMERCURY LYASE

(Escherichia
coli) 		PF03243
(MerB)
PF12324
(HTH_15) 		5 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.90A 1eqgA-5c0uA:
undetectable		 1eqgA-5c0uA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		5 VAL A 362
VAL A 442
LEU A 385
ILE A 348
LEU A 367
 CME  A 352 ( 4.0A)
None
None
None
None
 1.04A 1eqgA-5d8gA:
undetectable		 1eqgA-5d8gA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fac ALANINE RACEMASE

(Streptomyces
coelicolor) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 VAL A 272
VAL A 318
LEU A 338
ALA A 347
LEU A 269
 None
 1.18A 1eqgA-5facA:
undetectable		 1eqgA-5facA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.34A 1eqgA-5ikrA:
59.2		 1eqgA-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		5 VAL A 312
LEU A 159
ALA A 209
SER A 212
LEU A 213
 1YN  A 602 ( 4.3A)
None
None
None
None
 1.19A 1eqgA-5jlcA:
undetectable		 1eqgA-5jlcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		5 VAL A 199
VAL A  73
LEU A 178
SER A  77
LEU A 214
 None
 1.03A 1eqgA-5mq6A:
undetectable		 1eqgA-5mq6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		5 VAL A 283
TYR A 516
LEU A 517
ILE A 491
LEU A 285
 None
 1.12A 1eqgA-5ntfA:
undetectable		 1eqgA-5ntfA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 VAL A 292
VAL A 302
LEU A 333
ILE A 282
LEU A 294
 None
 1.17A 1eqgA-5o0jA:
undetectable		 1eqgA-5o0jA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L9,
MITOCHONDRIAL

(Homo sapiens) 		PF01281
(Ribosomal_L9_N) 		5 VAL H 102
VAL H 114
ILE H  97
ALA H 129
LEU H 123
 None
 1.18A 1eqgA-5oolH:
undetectable		 1eqgA-5oolH:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo NITROGEN REGULATORY
PROTEIN P-II 1

(Azospirillum
brasilense) 		no annotation 5 VAL B  63
VAL B  16
LEU B  20
ILE B  91
ALA B   6
 ADP  B 201 (-4.0A)
None
None
None
None
 0.93A 1eqgA-5ovoB:
undetectable		 1eqgA-5ovoB:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 VAL A 137
ILE A 395
ALA A 398
SER A 401
LEU A 404
 None
SO4  A1209 (-4.5A)
SO4  A1209 ( 3.9A)
None
None
 1.18A 1eqgA-5u09A:
undetectable		 1eqgA-5u09A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um0 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Neisseria
gonorrhoeae) 		PF00300
(His_Phos_1) 		5 VAL A   4
VAL A  67
LEU A  42
ALA A 179
LEU A 177
 None
 1.20A 1eqgA-5um0A:
undetectable		 1eqgA-5um0A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpb HISTONE DEACETYLASE
6

(Homo sapiens) 		PF02148
(zf-UBP) 		5 VAL A1190
VAL A1119
LEU A1172
ALA A1194
LEU A1195
 None
 1.08A 1eqgA-5wpbA:
undetectable		 1eqgA-5wpbA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 5 VAL A 131
VAL A 161
LEU A 172
ILE A 140
LEU A 222
 None
 1.12A 1eqgA-5wypA:
undetectable		 1eqgA-5wypA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 5 VAL A  26
VAL A  18
ILE A  83
SER A  89
LEU A  90
 None
 1.16A 1eqgA-5xmdA:
undetectable		 1eqgA-5xmdA:
8.45