SIMILAR PATTERNS OF AMINO ACIDS FOR 1EQB_D_GLYD4292_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 HIS A 133
SER A 179
LYS A 236
ARG A 361
 None
None
SO4  A 400 ( 3.0A)
None
 1.24A 1eqbC-1bs0A:
28.9
1eqbD-1bs0A:
28.9		 1eqbC-1bs0A:
24.22
1eqbD-1bs0A:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		6 SER A  35
HIS A 126
SER A 175
HIS A 203
LYS A 229
ARG A 363
 None
PLP  A2291 ( 3.8A)
PLP  A2291 (-2.9A)
PLP  A2291 (-4.0A)
PLP  A2291 (-1.4A)
None
 0.73A 1eqbC-1cj0A:
51.3
1eqbD-1cj0A:
50.9		 1eqbC-1cj0A:
45.22
1eqbD-1cj0A:
45.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		4 SER C3119
HIS C3157
HIS C3159
ARG A1421
 None
 1.33A 1eqbC-1e6yC:
undetectable
1eqbD-1e6yC:
undetectable		 1eqbC-1e6yC:
20.15
1eqbD-1e6yC:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		4 SER C3119
SER C3160
HIS C3159
ARG A1421
 None
 1.12A 1eqbC-1e6yC:
undetectable
1eqbD-1e6yC:
undetectable		 1eqbC-1e6yC:
20.15
1eqbD-1e6yC:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 HIS A 136
SER A 185
HIS A 213
LYS A 244
ARG A 368
 PLP  A1201 ( 3.4A)
AKB  A1200 ( 2.9A)
PLP  A1201 ( 3.9A)
PLP  A1201 ( 2.9A)
AKB  A1200 (-2.6A)
 0.93A 1eqbC-1fc4A:
29.2
1eqbD-1fc4A:
28.9		 1eqbC-1fc4A:
26.22
1eqbD-1fc4A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		4 SER A  29
HIS A 437
SER A  25
ARG A  33
 None
CUZ  A4801 (-3.0A)
None
None
 0.98A 1eqbC-1fwxA:
undetectable
1eqbD-1fwxA:
undetectable		 1eqbC-1fwxA:
21.68
1eqbD-1fwxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE
METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		4 SER C 118
SER C 159
HIS C 158
ARG A 401
 None
 1.18A 1eqbC-1mroC:
undetectable
1eqbD-1mroC:
undetectable		 1eqbC-1mroC:
19.66
1eqbD-1mroC:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		4 PHE A 216
HIS A 238
SER A 231
HIS A 232
 None
None
None
K  A 502 (-3.8A)
 1.30A 1eqbC-1p9eA:
undetectable
1eqbD-1p9eA:
undetectable		 1eqbC-1p9eA:
23.47
1eqbD-1p9eA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz9 KYNURENINASE

(Pseudomonas
fluorescens) 		PF00266
(Aminotran_5) 		4 SER A  36
HIS A 204
LYS A 227
ARG A 375
 P3G  A 701 ( 2.9A)
PLP  A1227 ( 4.0A)
PLP  A1227 (-1.3A)
CL  A 601 (-3.1A)
 0.89A 1eqbC-1qz9A:
26.8
1eqbD-1qz9A:
26.8		 1eqbC-1qz9A:
24.63
1eqbD-1qz9A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 TYR A 499
PHE A 500
SER A 543
HIS A 488
 None
 1.17A 1eqbC-1u1hA:
undetectable
1eqbD-1u1hA:
undetectable		 1eqbC-1u1hA:
20.42
1eqbD-1u1hA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyp BETA-FRUCTOSIDASE

(Thermotoga
maritima) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE A 393
SER A 401
HIS A   7
SER A 389
 None
 1.15A 1eqbC-1uypA:
undetectable
1eqbD-1uypA:
undetectable		 1eqbC-1uypA:
21.81
1eqbD-1uypA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN

(Thermus
thermophilus) 		PF06778
(Chlor_dismutase) 		4 TYR A 145
HIS A 172
SER A 223
ARG A 218
 None
 1.18A 1eqbC-1vdhA:
undetectable
1eqbD-1vdhA:
undetectable		 1eqbC-1vdhA:
19.48
1eqbD-1vdhA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		4 TYR A  41
SER A  45
HIS A  28
SER A  54
 None
 1.30A 1eqbC-1xmxA:
undetectable
1eqbD-1xmxA:
undetectable		 1eqbC-1xmxA:
20.13
1eqbD-1xmxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH

(Desulfovibrio
vulgaris) 		PF01814
(Hemerythrin) 		4 TYR A 126
PHE A  67
HIS A 118
HIS A  59
 None
None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 1.24A 1eqbC-2awcA:
undetectable
1eqbD-2awcA:
undetectable		 1eqbC-2awcA:
15.44
1eqbD-2awcA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwp 5-AMINOLEVULINATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00155
(Aminotran_1_2) 		4 HIS A 142
HIS A 217
LYS A 248
ARG A 374
 PLG  A 500 (-3.4A)
PLG  A 500 (-3.8A)
PLG  A 500 (-2.7A)
PLG  A 500 ( 4.0A)
 1.12A 1eqbC-2bwpA:
28.5
1eqbD-2bwpA:
28.1		 1eqbC-2bwpA:
23.80
1eqbD-2bwpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwp 5-AMINOLEVULINATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00155
(Aminotran_1_2) 		4 SER A 189
HIS A 217
LYS A 248
ARG A 374
 PLG  A 500 (-3.6A)
PLG  A 500 (-3.8A)
PLG  A 500 (-2.7A)
PLG  A 500 ( 4.0A)
 1.19A 1eqbC-2bwpA:
28.5
1eqbD-2bwpA:
28.1		 1eqbC-2bwpA:
23.80
1eqbD-2bwpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 TYR A 276
PHE A 266
SER A 262
HIS A 280
 None
 0.95A 1eqbC-2cy7A:
undetectable
1eqbD-2cy7A:
undetectable		 1eqbC-2cy7A:
20.50
1eqbD-2cy7A:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		6 SER A  31
HIS A 122
SER A 172
HIS A 200
LYS A 226
ARG A 358
 SO4  A2520 (-2.7A)
PLP  A 510 (-3.5A)
PLP  A 510 ( 3.2A)
SO4  A2520 ( 4.0A)
PLP  A 510 ( 1.3A)
SO4  A2520 (-2.9A)
 0.50A 1eqbC-2dkjA:
61.8
1eqbD-2dkjA:
60.6		 1eqbC-2dkjA:
59.52
1eqbD-2dkjA:
59.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE

(Pseudomonas
aeruginosa) 		no annotation 4 SER A 704
HIS A 651
HIS A 710
LYS A 702
 ATP  A1304 (-2.6A)
ATP  A1304 (-4.1A)
ATP  A1304 (-3.9A)
None
 1.29A 1eqbC-2faqA:
undetectable
1eqbD-2faqA:
undetectable		 1eqbC-2faqA:
22.76
1eqbD-2faqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu2 ASPA PROTEIN

(Rattus
norvegicus) 		PF04952
(AstE_AspA) 		4 TYR A 287
PHE A 281
HIS A  20
HIS A 183
 None
None
ZN  A 601 (-3.3A)
None
 1.32A 1eqbC-2gu2A:
undetectable
1eqbD-2gu2A:
undetectable		 1eqbC-2gu2A:
21.05
1eqbD-2gu2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib5 CHROMO PROTEIN

(Epiactis
japonica) 		PF01353
(GFP) 		4 TYR A 178
PHE A  80
HIS A 197
SER A 195
 None
None
CRQ  A  65 ( 3.7A)
None
 1.18A 1eqbC-2ib5A:
undetectable
1eqbD-2ib5A:
undetectable		 1eqbC-2ib5A:
19.95
1eqbD-2ib5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n03 PLECTIN

(Homo sapiens) 		PF00681
(Plectin) 		4 TYR A4517
HIS A4401
SER A4400
HIS A4395
 None
 1.31A 1eqbC-2n03A:
undetectable
1eqbD-2n03A:
undetectable		 1eqbC-2n03A:
19.19
1eqbD-2n03A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlz TRANSCRIPTION FACTOR
PF0095

(Pyrococcus
furiosus) 		PF12840
(HTH_20) 		4 SER A  19
SER A  32
HIS A  20
ARG A 187
 None
 1.18A 1eqbC-2qlzA:
undetectable
1eqbD-2qlzA:
undetectable		 1eqbC-2qlzA:
20.34
1eqbD-2qlzA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm0 BES

(Bacillus cereus) 		PF00756
(Esterase) 		4 PHE A  56
HIS A 254
SER A 181
LYS A 158
 None
SVY  A 157 ( 3.8A)
None
SVY  A 157 ( 2.9A)
 1.00A 1eqbC-2qm0A:
undetectable
1eqbD-2qm0A:
undetectable		 1eqbC-2qm0A:
22.14
1eqbD-2qm0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Paraburkholderia
phymatum) 		PF13377
(Peripla_BP_3) 		4 TYR A 305
HIS A 318
SER A 352
ARG A 354
 None
 1.09A 1eqbC-2rgyA:
3.0
1eqbD-2rgyA:
2.0		 1eqbC-2rgyA:
21.18
1eqbD-2rgyA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		6 SER A  31
HIS A 122
SER A 172
HIS A 200
LYS A 226
ARG A 357
 ALO  A 502 (-2.7A)
PLP  A 501 ( 3.4A)
ALO  A 502 (-3.9A)
ALO  A 502 ( 3.9A)
PLP  A 501 ( 3.6A)
ALO  A 502 (-3.0A)
 0.50A 1eqbC-2vmxA:
62.0
1eqbD-2vmxA:
61.5		 1eqbC-2vmxA:
58.85
1eqbD-2vmxA:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		4 HIS A 133
SER A 177
HIS A 205
ARG A 358
 PLP  A 600 (-3.4A)
PLP  A 600 (-3.5A)
PLP  A 600 (-3.9A)
None
 0.72A 1eqbC-2wk8A:
28.3
1eqbD-2wk8A:
28.3		 1eqbC-2wk8A:
22.94
1eqbD-2wk8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		4 HIS A 133
SER A 177
HIS A 205
LYS A 236
 PLP  A 600 (-3.4A)
PLP  A 600 (-3.5A)
PLP  A 600 (-3.9A)
PLP  A 600 (-2.6A)
 1.06A 1eqbC-2wk8A:
28.3
1eqbD-2wk8A:
28.3		 1eqbC-2wk8A:
22.94
1eqbD-2wk8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A

(Brevibacillus
brevis) 		PF00668
(Condensation) 		4 SER A 322
HIS A 463
SER A 459
LYS A 326
 None
 1.15A 1eqbC-2xhgA:
undetectable
1eqbD-2xhgA:
undetectable		 1eqbC-2xhgA:
23.31
1eqbD-2xhgA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu2 UPF0271 PROTEIN
PA4511

(Pseudomonas
aeruginosa) 		PF03746
(LamB_YcsF) 		4 TYR A 121
HIS A 232
HIS A  68
LYS A 115
 CIT  A1249 ( 4.4A)
CIT  A1249 (-3.7A)
CIT  A1249 (-4.4A)
CIT  A1249 (-2.7A)
 1.16A 1eqbC-2xu2A:
undetectable
1eqbD-2xu2A:
undetectable		 1eqbC-2xu2A:
20.95
1eqbD-2xu2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2b SERINE
PALMITOYLTRANSFERASE

(Sphingobacterium
multivorum) 		PF00155
(Aminotran_1_2) 		5 HIS A 138
SER A 185
HIS A 213
LYS A 244
ARG A 367
 PLP  A 400 ( 3.2A)
PLP  A 400 ( 4.2A)
PLP  A 400 (-4.1A)
PLP  A 400 ( 3.3A)
None
 1.14A 1eqbC-3a2bA:
28.6
1eqbD-3a2bA:
28.2		 1eqbC-3a2bA:
25.11
1eqbD-3a2bA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD

(Ruegeria
pomeroyi) 		PF05853
(BKACE) 		4 TYR A 123
PHE A 118
HIS A  53
SER A  18
 None
None
ZN  A 302 (-3.2A)
None
 1.16A 1eqbC-3chvA:
undetectable
1eqbD-3chvA:
undetectable		 1eqbC-3chvA:
23.31
1eqbD-3chvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD

(Ruegeria
pomeroyi) 		PF05853
(BKACE) 		4 TYR A 123
PHE A 118
HIS A  53
SER A  92
 None
None
ZN  A 302 (-3.2A)
None
 1.07A 1eqbC-3chvA:
undetectable
1eqbD-3chvA:
undetectable		 1eqbC-3chvA:
23.31
1eqbD-3chvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1

(Cavia porcellus) 		PF00106
(adh_short) 		4 PHE A 194
SER A 151
HIS A 120
SER A 146
 None
 1.27A 1eqbC-3dwfA:
3.2
1eqbD-3dwfA:
3.2		 1eqbC-3dwfA:
20.95
1eqbD-3dwfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzb PREPHENATE
DEHYDROGENASE

(Streptococcus
thermophilus) 		PF02153
(PDH) 		4 SER A  99
HIS A 193
SER A 189
HIS A 190
 None
 1.14A 1eqbC-3dzbA:
3.4
1eqbD-3dzbA:
3.4		 1eqbC-3dzbA:
22.14
1eqbD-3dzbA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)

(Paracoccus
denitrificans) 		PF05853
(BKACE) 		4 TYR A 123
PHE A 118
HIS A  53
SER A  18
 None
None
MG  A 282 (-3.5A)
None
 1.18A 1eqbC-3fa5A:
undetectable
1eqbD-3fa5A:
undetectable		 1eqbC-3fa5A:
21.91
1eqbD-3fa5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)

(Paracoccus
denitrificans) 		PF05853
(BKACE) 		4 TYR A 123
PHE A 118
HIS A  53
SER A  92
 None
None
MG  A 282 (-3.5A)
None
 1.14A 1eqbC-3fa5A:
undetectable
1eqbD-3fa5A:
undetectable		 1eqbC-3fa5A:
21.91
1eqbD-3fa5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fle SE_1780 PROTEIN

(Staphylococcus
epidermidis) 		PF06028
(DUF915) 		4 SER A  60
HIS A 269
SER A 270
HIS A 273
 None
 1.13A 1eqbC-3fleA:
undetectable
1eqbD-3fleA:
undetectable		 1eqbC-3fleA:
20.10
1eqbD-3fleA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		4 HIS A 126
HIS A 203
LYS A 229
ARG A 363
 PLP  A 418 (-4.1A)
None
PLP  A 418 (-1.5A)
None
 0.89A 1eqbC-3g8mA:
58.2
1eqbD-3g8mA:
58.1		 1eqbC-3g8mA:
99.52
1eqbD-3g8mA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1

(Mycobacterium
tuberculosis) 		PF00464
(SHMT) 		4 SER A  32
HIS A 123
SER A 173
HIS A 201
 None
LLP  A 227 ( 3.6A)
None
LLP  A 227 ( 4.2A)
 0.74A 1eqbC-3h7fA:
55.9
1eqbD-3h7fA:
54.8		 1eqbC-3h7fA:
51.43
1eqbD-3h7fA:
51.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 HIS B 467
SER B  75
HIS B 360
ARG B 282
 CO  B 563 ( 3.1A)
CO  B 563 (-1.8A)
3PG  B 564 ( 4.2A)
3PG  B 564 ( 2.8A)
 1.27A 1eqbC-3igzB:
undetectable
1eqbD-3igzB:
undetectable		 1eqbC-3igzB:
21.80
1eqbD-3igzB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR PRP5

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 PHE K 346
SER K 348
HIS K 329
HIS K 330
 None
 1.23A 1eqbC-3jb9K:
undetectable
1eqbD-3jb9K:
undetectable		 1eqbC-3jb9K:
17.65
1eqbD-3jb9K:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no5 UNCHARACTERIZED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF05853
(BKACE) 		4 TYR A 119
PHE A 114
HIS A  49
SER A  14
 None
None
ZN  A 275 (-3.3A)
None
 1.23A 1eqbC-3no5A:
undetectable
1eqbD-3no5A:
undetectable		 1eqbC-3no5A:
21.77
1eqbD-3no5A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF02126
(PTE) 		4 PHE A 326
SER A 212
HIS A  22
SER A 236
 None
None
ZN  A 333 ( 3.3A)
None
 1.30A 1eqbC-3pnzA:
undetectable
1eqbD-3pnzA:
undetectable		 1eqbC-3pnzA:
22.45
1eqbD-3pnzA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 TYR A 508
PHE A 509
SER A 552
HIS A 497
 None
 1.23A 1eqbC-3ppcA:
undetectable
1eqbD-3ppcA:
undetectable		 1eqbC-3ppcA:
21.41
1eqbD-3ppcA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrt FUSION GLYCOPROTEIN
F0

(Human
orthopneumovirus) 		PF00523
(Fusion_gly) 		4 TYR B 299
PHE B 237
SER B 287
SER B 248
 None
 1.22A 1eqbC-3rrtB:
undetectable
1eqbD-3rrtB:
undetectable		 1eqbC-3rrtB:
22.49
1eqbD-3rrtB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE X 473
SER X 482
HIS X  33
SER X 469
 None
 1.13A 1eqbC-3rwkX:
undetectable
1eqbD-3rwkX:
undetectable		 1eqbC-3rwkX:
22.69
1eqbD-3rwkX:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE

(Glycine max) 		PF00291
(PALP) 		4 TYR A 241
PHE A 207
SER A 244
LYS A 245
 None
 1.07A 1eqbC-3vbeA:
undetectable
1eqbD-3vbeA:
undetectable		 1eqbC-3vbeA:
22.12
1eqbD-3vbeA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wau 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE

(Bacteroides
fragilis) 		PF04041
(Glyco_hydro_130) 		4 TYR A 246
PHE A 369
SER A 302
LYS A 251
 None
 1.23A 1eqbC-3wauA:
undetectable
1eqbD-3wauA:
undetectable		 1eqbC-3wauA:
22.27
1eqbD-3wauA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 SER A 568
HIS A 525
HIS A 567
ARG A 574
 None
MTT  A 802 (-3.9A)
None
None
 1.30A 1eqbC-3wdjA:
undetectable
1eqbD-3wdjA:
undetectable		 1eqbC-3wdjA:
21.21
1eqbD-3wdjA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 4 PHE A 456
SER A 432
SER A 402
HIS A 401
 None
 1.31A 1eqbC-4a7kA:
undetectable
1eqbD-4a7kA:
undetectable		 1eqbC-4a7kA:
18.65
1eqbD-4a7kA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 SER A  66
HIS A 191
HIS A 100
ARG A 189
 None
 1.15A 1eqbC-4b92A:
undetectable
1eqbD-4b92A:
undetectable		 1eqbC-4b92A:
23.09
1eqbD-4b92A:
23.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 SER A  30
HIS A 121
HIS A 199
LYS A 226
ARG A 363
 None
 0.72A 1eqbC-4bhdA:
48.2
1eqbD-4bhdA:
47.8		 1eqbC-4bhdA:
35.99
1eqbD-4bhdA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 SER A  30
HIS A 121
SER A 171
HIS A 199
LYS A 226
 None
 0.96A 1eqbC-4bhdA:
48.2
1eqbD-4bhdA:
47.8		 1eqbC-4bhdA:
35.99
1eqbD-4bhdA:
35.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 TYR B  22
PHE B  18
SER B  67
HIS B  62
 None
 1.22A 1eqbC-4ccyB:
undetectable
1eqbD-4ccyB:
undetectable		 1eqbC-4ccyB:
23.37
1eqbD-4ccyB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		4 HIS A 278
SER A  37
HIS A  36
LYS A 341
 None
 1.32A 1eqbC-4e8dA:
undetectable
1eqbD-4e8dA:
undetectable		 1eqbC-4e8dA:
22.62
1eqbD-4e8dA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE A 477
SER A 486
HIS A  44
SER A 473
 None
 1.21A 1eqbC-4fffA:
undetectable
1eqbD-4fffA:
undetectable		 1eqbC-4fffA:
20.83
1eqbD-4fffA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		5 HIS A 121
SER A 163
HIS A 188
LYS A 220
ARG A 344
 None
 1.03A 1eqbC-4iw7A:
27.3
1eqbD-4iw7A:
27.3		 1eqbC-4iw7A:
22.51
1eqbD-4iw7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		4 SER A  35
SER A 163
HIS A 188
LYS A 220
 None
 1.12A 1eqbC-4iw7A:
27.3
1eqbD-4iw7A:
27.3		 1eqbC-4iw7A:
22.51
1eqbD-4iw7A:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		4 SER A  35
HIS A 126
SER A 176
HIS A 204
 LLP  A 230 ( 4.9A)
LLP  A 230 ( 3.5A)
None
LLP  A 230 ( 4.1A)
 0.69A 1eqbC-4j5uA:
60.8
1eqbD-4j5uA:
60.8		 1eqbC-4j5uA:
55.79
1eqbD-4j5uA:
55.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx9 ARCHAEAL
AMINO-TERMINAL
ACETYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF00583
(Acetyltransf_1) 		4 TYR A  86
PHE A  90
HIS A 137
ARG A 118
 None
None
ZN  A 302 (-3.3A)
None
 1.15A 1eqbC-4lx9A:
undetectable
1eqbD-4lx9A:
undetectable		 1eqbC-4lx9A:
17.99
1eqbD-4lx9A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmq FUSION GLYCOPROTEIN
F1 FUSED WITH
FIBRITIN
TRIMERIZATION DOMAIN

(Escherichia
virus T4;
Human
orthopneumovirus) 		PF00523
(Fusion_gly) 		4 TYR B 299
PHE B 237
SER B 287
SER B 248
 None
 1.23A 1eqbC-4mmqB:
undetectable
1eqbD-4mmqB:
undetectable		 1eqbC-4mmqB:
21.52
1eqbD-4mmqB:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		4 SER A  34
HIS A 129
HIS A 211
LYS A 237
 None
PLP  A 701 (-3.6A)
PLP  A 701 (-4.0A)
PLP  A 701 (-1.5A)
 0.56A 1eqbC-4o6zA:
54.8
1eqbD-4o6zA:
55.6		 1eqbC-4o6zA:
38.51
1eqbD-4o6zA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		4 SER A  34
HIS A 211
LYS A 237
ARG A 371
 None
PLP  A 701 (-4.0A)
PLP  A 701 (-1.5A)
None
 0.59A 1eqbC-4o6zA:
54.8
1eqbD-4o6zA:
55.6		 1eqbC-4o6zA:
38.51
1eqbD-4o6zA:
38.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qla JUVENILE HORMONE
EPOXIDE HYDROLASE

(Bombyx mori) 		PF06441
(EHN) 		4 SER A 157
HIS A 131
SER A 185
HIS A 152
 None
 1.16A 1eqbC-4qlaA:
undetectable
1eqbD-4qlaA:
undetectable		 1eqbC-4qlaA:
21.97
1eqbD-4qlaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF08662
(eIF2A) 		4 TYR A 205
PHE A 207
SER A 200
SER A 239
 None
 1.22A 1eqbC-4u1fA:
undetectable
1eqbD-4u1fA:
undetectable		 1eqbC-4u1fA:
21.46
1eqbD-4u1fA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 SER A 521
HIS A 582
SER A 524
LYS A 494
 None
 1.16A 1eqbC-4u7mA:
undetectable
1eqbD-4u7mA:
undetectable		 1eqbC-4u7mA:
21.31
1eqbD-4u7mA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3B

(Lachancea
kluyveri) 		PF00318
(Ribosomal_S2) 		4 TYR b 271
PHE b 273
SER b 266
SER b 305
 None
 1.22A 1eqbC-4uerb:
undetectable
1eqbD-4uerb:
undetectable		 1eqbC-4uerb:
19.21
1eqbD-4uerb:
19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		5 SER A  29
SER A 170
HIS A 198
LYS A 224
ARG A 357
 CAC  A 502 (-3.2A)
CAC  A 502 ( 4.8A)
CAC  A 502 (-4.0A)
CIT  A 501 ( 2.8A)
CAC  A 502 (-3.1A)
 0.71A 1eqbC-4wxbA:
60.2
1eqbD-4wxbA:
59.0		 1eqbC-4wxbA:
58.60
1eqbD-4wxbA:
58.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb1 BLUE CHROMOPROTEIN,
SGBP

(Stichodactyla
gigantea) 		PF01353
(GFP) 		4 TYR A 177
PHE A  79
HIS A 196
SER A 194
 None
None
CRQ  A  62 ( 3.7A)
None
 1.15A 1eqbC-4zb1A:
undetectable
1eqbD-4zb1A:
undetectable		 1eqbC-4zb1A:
19.43
1eqbD-4zb1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 TYR A 503
PHE A 504
SER A 547
HIS A 492
 None
 1.25A 1eqbC-4ztxA:
undetectable
1eqbD-4ztxA:
undetectable		 1eqbC-4ztxA:
20.10
1eqbD-4ztxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 SER A 341
SER A 375
HIS A 373
LYS A 367
 C  E   0 ( 3.2A)
C  E   0 ( 2.5A)
C  E   0 ( 3.7A)
None
 1.22A 1eqbC-5a0tA:
undetectable
1eqbD-5a0tA:
undetectable		 1eqbC-5a0tA:
23.68
1eqbD-5a0tA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		4 SER C 121
HIS C 159
HIS C 161
ARG A 403
 None
 1.29A 1eqbC-5a8rC:
undetectable
1eqbD-5a8rC:
undetectable		 1eqbC-5a8rC:
21.12
1eqbD-5a8rC:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		4 SER C 121
SER C 162
HIS C 161
ARG A 403
 None
 1.09A 1eqbC-5a8rC:
undetectable
1eqbD-5a8rC:
undetectable		 1eqbC-5a8rC:
21.12
1eqbD-5a8rC:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeb LRA-12

(uncultured
bacterium BLR12) 		PF00753
(Lactamase_B) 		4 TYR A 290
PHE A 256
HIS A 192
SER A 202
 None
 1.32A 1eqbC-5aebA:
undetectable
1eqbD-5aebA:
undetectable		 1eqbC-5aebA:
21.98
1eqbD-5aebA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c69 FUSION GLYCOPROTEIN
F0,FIBRITIN

(Enterobacteria
phage Ox2;
Human
orthopneumovirus) 		PF00523
(Fusion_gly) 		4 TYR A 272
PHE A 210
SER A 260
SER A 221
 None
 1.24A 1eqbC-5c69A:
undetectable
1eqbD-5c69A:
undetectable		 1eqbC-5c69A:
21.70
1eqbD-5c69A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 TYR A 488
PHE A 452
SER A 256
HIS A 258
 None
 1.32A 1eqbC-5d0fA:
undetectable
1eqbD-5d0fA:
undetectable		 1eqbC-5d0fA:
14.35
1eqbD-5d0fA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus;
Influenza C
virus) 		PF00603
(Flu_PA)
PF00602
(Flu_PB1) 		4 PHE B  61
SER B  58
SER A 198
ARG B  65
 None
 1.31A 1eqbC-5d9aB:
undetectable
1eqbD-5d9aB:
undetectable		 1eqbC-5d9aB:
20.13
1eqbD-5d9aB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		4 SER A 102
HIS A  79
SER A 133
HIS A  97
 None
 1.20A 1eqbC-5f4zA:
undetectable
1eqbD-5f4zA:
undetectable		 1eqbC-5f4zA:
24.11
1eqbD-5f4zA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 TYR C 319
PHE C 316
SER C 378
SER C 271
 None
 1.27A 1eqbC-5flzC:
undetectable
1eqbD-5flzC:
undetectable		 1eqbC-5flzC:
22.00
1eqbD-5flzC:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		4 TYR A  61
PHE A  34
SER A 402
LYS A 412
 PO4  A1442 (-4.5A)
None
None
PO4  A1442 (-3.2A)
 1.06A 1eqbC-5g4iA:
21.0
1eqbD-5g4iA:
20.8		 1eqbC-5g4iA:
24.15
1eqbD-5g4iA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh9 PVDN

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		4 HIS A 148
SER A 205
HIS A 241
LYS A 264
 PLP  A 501 (-3.5A)
PLP  A 501 (-2.6A)
PLP  A 501 (-3.6A)
PLP  A 501 (-2.7A)
 1.19A 1eqbC-5hh9A:
29.0
1eqbD-5hh9A:
28.8		 1eqbC-5hh9A:
25.38
1eqbD-5hh9A:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 4 SER A  75
HIS A 125
SER A  71
ARG A  79
 None
 1.24A 1eqbC-5i5jA:
undetectable
1eqbD-5i5jA:
undetectable		 1eqbC-5i5jA:
20.60
1eqbD-5i5jA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Paraburkholderia
xenovorans) 		PF00155
(Aminotran_1_2) 		4 SER A 183
HIS A 211
LYS A 242
ARG A 367
 None
 1.30A 1eqbC-5jayA:
28.5
1eqbD-5jayA:
28.5		 1eqbC-5jayA:
24.89
1eqbD-5jayA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE

(Saccharomyces
cerevisiae) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 PHE A 842
SER A 917
HIS A 910
SER A 908
 None
 1.33A 1eqbC-5jm0A:
undetectable
1eqbD-5jm0A:
undetectable		 1eqbC-5jm0A:
17.89
1eqbD-5jm0A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus;
Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		4 SER C 121
SER C 163
HIS C 162
ARG A 403
 None
 1.17A 1eqbC-5n28C:
undetectable
1eqbD-5n28C:
undetectable		 1eqbC-5n28C:
21.45
1eqbD-5n28C:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdg FUSION GLYCOPROTEIN
F0,FIBRITIN

(Bovine
orthopneumovirus;
Enterobacteria
phage T4 sensu
lato) 		PF00523
(Fusion_gly)
PF07921
(Fibritin_C) 		4 TYR A 299
PHE A 237
SER A 287
SER A 248
 None
 1.19A 1eqbC-5tdgA:
undetectable
1eqbD-5tdgA:
undetectable		 1eqbC-5tdgA:
20.95
1eqbD-5tdgA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 4 HIS B 209
HIS B 284
LYS B 337
ARG B 461
 PLP  B 605 (-3.4A)
PLP  B 605 (-3.6A)
PLP  B 605 (-2.9A)
None
 1.33A 1eqbC-5txrB:
24.3
1eqbD-5txrB:
24.2		 1eqbC-5txrB:
undetectable
1eqbD-5txrB:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.25A 1eqbC-5v7iA:
51.7
1eqbD-5v7iA:
51.3		 1eqbC-5v7iA:
44.38
1eqbD-5v7iA:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 PHE A1216
SER A1272
SER A1122
HIS A1173
 PRO  A1602 (-4.3A)
PRO  A1602 (-3.3A)
None
PRO  A1602 ( 4.5A)
 1.13A 1eqbC-5vadA:
undetectable
1eqbD-5vadA:
undetectable		 1eqbC-5vadA:
22.81
1eqbD-5vadA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		4 SER A  32
SER A 172
LYS A 226
ARG A 358
 None
 0.71A 1eqbC-5vc2A:
52.9
1eqbD-5vc2A:
53.0		 1eqbC-5vc2A:
51.88
1eqbD-5vc2A:
51.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 SER A  34
SER A 175
HIS A 203
LYS A 229
ARG A 362
 None
 0.75A 1eqbC-5vmbA:
58.3
1eqbD-5vmbA:
57.3		 1eqbC-5vmbA:
71.06
1eqbD-5vmbA:
71.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Burkholderia
multivorans) 		PF00155
(Aminotran_1_2) 		4 HIS A 137
SER A 183
HIS A 211
ARG A 367
 9EV  A 242 ( 3.5A)
9EV  A 242 ( 2.9A)
9EV  A 242 ( 3.5A)
None
 1.09A 1eqbC-5vnxA:
28.8
1eqbD-5vnxA:
28.4		 1eqbC-5vnxA:
25.17
1eqbD-5vnxA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 HIS A 445
SER A  67
HIS A 339
ARG A 262
 MN  A 602 ( 3.2A)
MN  A 602 ( 1.8A)
3PG  A 603 (-4.3A)
3PG  A 603 (-3.0A)
 1.28A 1eqbC-5vpuA:
undetectable
1eqbD-5vpuA:
undetectable		 1eqbC-5vpuA:
23.02
1eqbD-5vpuA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
vivax) 		no annotation 5 SER A  34
HIS A 129
HIS A 211
LYS A 237
ARG A 371
 PLG  A 501 (-2.4A)
PLG  A 501 ( 3.5A)
PLG  A 501 (-3.8A)
PLG  A 501 (-3.4A)
PLG  A 501 (-3.1A)
 0.25A 1eqbC-5xmrA:
56.1
1eqbD-5xmrA:
56.8		 1eqbC-5xmrA:
40.55
1eqbD-5xmrA:
40.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Homo sapiens) 		PF15879
(MWFE) 		4 PHE s 242
SER s 178
SER s 152
HIS s 304
 None
 1.08A 1eqbC-5xtds:
undetectable
1eqbD-5xtds:
undetectable		 1eqbC-5xtds:
20.56
1eqbD-5xtds:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 4 PHE A 158
SER A 219
HIS A  95
SER A  96
 TLF  A 300 (-4.6A)
TLF  A 300 (-2.7A)
None
TLF  A 300 (-2.6A)
 1.33A 1eqbC-6ap6A:
undetectable
1eqbD-6ap6A:
undetectable		 1eqbC-6ap6A:
undetectable
1eqbD-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 4 TYR A 169
PHE A 182
HIS A 133
HIS A 131
 None
 1.31A 1eqbC-6byxA:
undetectable
1eqbD-6byxA:
undetectable		 1eqbC-6byxA:
undetectable
1eqbD-6byxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 5 SER A 114
HIS A 209
SER A 264
HIS A 292
ARG A 454
 ACT  A 612 (-2.3A)
LLP  A 318 (-3.5A)
ACT  A 612 (-2.7A)
LLP  A 318 (-3.4A)
ACT  A 612 (-2.9A)
 0.62A 1eqbC-6cczA:
56.1
1eqbD-6cczA:
56.9		 1eqbC-6cczA:
undetectable
1eqbD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC4

(Saccharomyces
cerevisiae) 		no annotation 4 SER N 372
HIS N 366
LYS N 370
ARG N 364
 None
 1.02A 1eqbC-6eu2N:
undetectable
1eqbD-6eu2N:
undetectable		 1eqbC-6eu2N:
undetectable
1eqbD-6eu2N:
undetectable