SIMILAR PATTERNS OF AMINO ACIDS FOR 1EQB_C_FFOC3293_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ar1 CYTOCHROME C OXIDASE

(Paracoccus
denitrificans) 		PF00116
(COX2)
PF02790
(COX2_TM) 		3 GLU B 153
TYR B 149
PHE B 213
 None
 0.54A 1eqbD-1ar1B:
undetectable		 1eqbD-1ar1B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		3 GLU A 469
TYR A 465
PHE A 453
 None
 0.74A 1eqbD-1b41A:
undetectable		 1eqbD-1b41A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		3 GLU A 469
TYR A 465
PHE A 453
 None
 0.87A 1eqbD-1c2oA:
undetectable		 1eqbD-1c2oA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLU A 379
TYR A 445
PHE A 381
 None
 0.86A 1eqbD-1ciyA:
undetectable		 1eqbD-1ciyA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		3 GLU A  57
TYR A  64
PHE A 257
 None
 0.66A 1eqbD-1cj0A:
50.9		 1eqbD-1cj0A:
45.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlm CATECHOL
1,2-DIOXYGENASE

(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 GLU A 106
TYR A 110
PHE A 228
 None
 0.78A 1eqbD-1dlmA:
undetectable		 1eqbD-1dlmA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		3 GLU A 462
TYR A 458
PHE A 446
 None
 0.89A 1eqbD-1gqrA:
undetectable		 1eqbD-1gqrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i31 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		3 GLU A 172
TYR A 205
PHE A 174
 None
 0.77A 1eqbD-1i31A:
undetectable		 1eqbD-1i31A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		3 GLU A 112
TYR A  15
PHE A 108
 None
 0.86A 1eqbD-1ihpA:
undetectable		 1eqbD-1ihpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 GLU A 184
TYR A 181
PHE A 484
 None
 0.96A 1eqbD-1jf5A:
undetectable		 1eqbD-1jf5A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0w RIBONUCLEASE III

(Thermotoga
maritima) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		3 GLU A 226
TYR A 169
PHE A 155
 None
 0.94A 1eqbD-1o0wA:
undetectable		 1eqbD-1o0wA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		3 GLU A 117
TYR A 120
PHE A  72
 None
 0.82A 1eqbD-1o2dA:
4.0		 1eqbD-1o2dA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C) 		3 GLU D 728
TYR D 644
PHE D 662
 None
 0.94A 1eqbD-1o7dD:
undetectable		 1eqbD-1o7dD:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 GLU A 265
TYR A 296
PHE A 268
 None
 0.51A 1eqbD-1q5aA:
undetectable		 1eqbD-1q5aA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		3 GLU A 580
TYR A 578
PHE A 374
 None
 0.54A 1eqbD-1qhbA:
undetectable		 1eqbD-1qhbA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE II

(Paracoccus
denitrificans) 		PF00116
(COX2)
PF02790
(COX2_TM) 		3 GLU B 153
TYR B 149
PHE B 213
 None
 0.76A 1eqbD-1qleB:
undetectable		 1eqbD-1qleB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri7 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Pyrococcus
horikoshii) 		PF01037
(AsnC_trans_reg)
PF13404
(HTH_AsnC-type) 		3 GLU A 112
TYR A 110
PHE A 140
 None
 0.80A 1eqbD-1ri7A:
undetectable		 1eqbD-1ri7A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		3 GLU A  63
TYR A 169
PHE A 344
 MG  A1601 ( 2.7A)
None
None
 0.92A 1eqbD-1t8qA:
undetectable		 1eqbD-1t8qA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2

(Homo sapiens) 		PF10275
(Peptidase_C65) 		3 GLU A 194
TYR A 217
PHE A  39
 None
 0.81A 1eqbD-1tffA:
undetectable		 1eqbD-1tffA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor;
Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 GLU B 160
TYR B 334
PHE A 140
 None
 0.83A 1eqbD-1tqyB:
undetectable		 1eqbD-1tqyB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u84 HYPOTHETICAL PROTEIN

(Geobacillus
stearothermophilus) 		PF08958
(DUF1871) 		3 GLU A  30
TYR A  27
PHE A  59
 None
 0.60A 1eqbD-1u84A:
undetectable		 1eqbD-1u84A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlm SAM-DEPENDENT
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		3 GLU A  26
TYR A  23
PHE A  49
 None
 0.95A 1eqbD-1vlmA:
undetectable		 1eqbD-1vlmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE

(Streptococcus
pneumoniae) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		3 GLU A 260
TYR A 276
PHE A 262
 None
EDO  A 402 ( 3.4A)
EDO  A 408 (-4.1A)
 0.68A 1eqbD-1vqzA:
undetectable		 1eqbD-1vqzA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcu NON-CATALYTIC
PROTEIN 1

(Piromyces equi) 		no annotation 3 GLU A  88
TYR A  84
PHE A  90
 None
 0.95A 1eqbD-1wcuA:
undetectable		 1eqbD-1wcuA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 GLU A 167
TYR A 194
PHE A 169
 None
 0.67A 1eqbD-1we5A:
undetectable		 1eqbD-1we5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 GLU A 295
TYR A 125
PHE A 315
 None
 0.90A 1eqbD-1xrcA:
undetectable		 1eqbD-1xrcA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		3 GLU A  57
TYR A  83
PHE A  63
 None
 0.88A 1eqbD-1z7mA:
undetectable		 1eqbD-1z7mA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284

(Homo sapiens) 		PF00179
(UQ_con) 		3 GLU A  52
TYR A  49
PHE A  54
 None
 0.85A 1eqbD-2a7lA:
undetectable		 1eqbD-2a7lA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azq CATECHOL
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 GLU A 105
TYR A 109
PHE A 224
 None
 0.78A 1eqbD-2azqA:
undetectable		 1eqbD-2azqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp5 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		3 GLU M 172
TYR M 205
PHE M 174
 None
 0.78A 1eqbD-2bp5M:
undetectable		 1eqbD-2bp5M:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE

(Campylobacter
jejuni) 		PF08761
(dUTPase_2) 		3 GLU A 223
TYR A 226
PHE A 181
 None
 0.94A 1eqbD-2cicA:
undetectable		 1eqbD-2cicA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyy PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PH1519

(Pyrococcus
horikoshii) 		PF01037
(AsnC_trans_reg)
PF13404
(HTH_AsnC-type) 		3 GLU A  92
TYR A  90
PHE A 120
 None
 0.78A 1eqbD-2cyyA:
undetectable		 1eqbD-2cyyA:
16.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		3 GLU A  53
TYR A  60
PHE A 252
 None
 0.38A 1eqbD-2dkjA:
60.6		 1eqbD-2dkjA:
59.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea3 CHYMOTRYPSIN

(Cellulomonas
bogoriensis) 		PF00089
(Trypsin) 		3 GLU A 119
TYR A 117
PHE A  52
 None
 0.64A 1eqbD-2ea3A:
undetectable		 1eqbD-2ea3A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE

(Enterococcus
faecalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		3 GLU A 382
TYR A 345
PHE A 308
 None
 0.87A 1eqbD-2j3mA:
undetectable		 1eqbD-2j3mA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mmy TATA-BINDING
PROTEIN-ASSOCIATED
FACTOR 2N

(Homo sapiens) 		PF00076
(RRM_1) 		3 GLU A 285
TYR A 274
PHE A 237
 None
 0.57A 1eqbD-2mmyA:
undetectable		 1eqbD-2mmyA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0g SELENOPROTEIN
W-RELATED PROTEIN

(Vibrio cholerae) 		PF10262
(Rdx) 		3 GLU A  49
TYR A   9
PHE A  51
 None
 0.72A 1eqbD-2p0gA:
undetectable		 1eqbD-2p0gA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfe ALKALINE SERINE
PROTEASE

(Thermobifida
fusca) 		PF00089
(Trypsin) 		3 GLU A 174
TYR A 171
PHE A  94
 None
 0.80A 1eqbD-2pfeA:
undetectable		 1eqbD-2pfeA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii) 		PF01823
(MACPF) 		3 GLU A 148
TYR A 221
PHE A 147
 None
 0.82A 1eqbD-2qp2A:
undetectable		 1eqbD-2qp2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE

(Agrobacterium
fabrum) 		PF06559
(DCD) 		3 GLU A 317
TYR A 294
PHE A 261
 None
 0.95A 1eqbD-2r9qA:
undetectable		 1eqbD-2r9qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri8 MANNOSYL-OLIGOSACCHA
RIDE
ALPHA-1,2-MANNOSIDAS
E

(Penicillium
citrinum) 		PF01532
(Glyco_hydro_47) 		3 GLU A1362
TYR A1365
PHE A1414
 NAG  A1700 (-4.7A)
None
None
 0.79A 1eqbD-2ri8A:
undetectable		 1eqbD-2ri8A:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		3 GLU A  53
TYR A  60
PHE A 251
 None
 0.49A 1eqbD-2vmxA:
61.5		 1eqbD-2vmxA:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS

(Fasciola
hepatica) 		PF14497
(GST_C_3) 		3 GLU A 103
TYR A 106
PHE A 162
 None
 0.94A 1eqbD-2wduA:
undetectable		 1eqbD-2wduA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdd TOXN

(Pectobacterium
atrosepticum) 		PF13958
(ToxN_toxin) 		3 GLU A  16
TYR A  13
PHE A  17
 None
 0.97A 1eqbD-2xddA:
undetectable		 1eqbD-2xddA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsr CATECHOL 1,2
DIOXYGENASE

(Acinetobacter
radioresistens) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 GLU A 102
TYR A 106
PHE A 223
 None
 0.69A 1eqbD-2xsrA:
undetectable		 1eqbD-2xsrA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt4 MCBG-LIKE PROTEIN

(Xanthomonas
albilineans) 		PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4) 		3 GLU A  14
TYR A  11
PHE A  16
 None
 0.85A 1eqbD-2xt4A:
undetectable		 1eqbD-2xt4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 GLU A  39
TYR A 215
PHE A  38
 None
 0.88A 1eqbD-3decA:
undetectable		 1eqbD-3decA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpu RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF08477
(Roc)
PF16095
(COR) 		3 GLU A 890
TYR A 904
PHE A 798
 None
 0.87A 1eqbD-3dpuA:
undetectable		 1eqbD-3dpuA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		3 GLU A  57
TYR A  64
PHE A 257
 None
 0.61A 1eqbD-3g8mA:
58.1		 1eqbD-3g8mA:
99.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Vibrio
parahaemolyticus) 		PF00106
(adh_short) 		3 GLU A 138
TYR A 141
PHE A  83
 None
 0.97A 1eqbD-3guyA:
2.8		 1eqbD-3guyA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxj PYRROLO-QUINOLINE
QUINONE

(Methanococcus
maripaludis) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13570
(PQQ_3) 		3 GLU A 286
TYR A 278
PHE A 250
 None
 0.96A 1eqbD-3hxjA:
undetectable		 1eqbD-3hxjA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4u BINDING COMPONENT OF
ABC TRANSPORTER

(Wolinella
succinogenes) 		PF00497
(SBP_bac_3) 		3 GLU A 143
TYR A  13
PHE A 160
 LYS  A 501 (-3.5A)
LYS  A 501 (-4.3A)
LYS  A 501 (-4.6A)
 0.81A 1eqbD-3k4uA:
undetectable		 1eqbD-3k4uA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00067
(p450) 		3 GLU A 116
TYR A 119
PHE A 450
 None
 0.90A 1eqbD-3k9yA:
undetectable		 1eqbD-3k9yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks7 PUTATIVE PUTATIVE
PNGASE F

(Bacteroides
fragilis) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		3 GLU A 373
TYR A 280
PHE A 311
 EDO  A 420 ( 3.5A)
None
EDO  A 418 ( 4.4A)
 0.95A 1eqbD-3ks7A:
undetectable		 1eqbD-3ks7A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		3 GLU A 278
TYR A 277
PHE A 233
 None
 0.95A 1eqbD-3mjoA:
undetectable		 1eqbD-3mjoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU

(Mus musculus;
Rattus
norvegicus) 		PF00610
(DEP)
PF00928
(Adap_comp_sub) 		3 GLU A1172
TYR A1205
PHE A1174
 None
 0.75A 1eqbD-3ml6A:
undetectable		 1eqbD-3ml6A:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		3 GLU A  52
TYR A  59
PHE A 250
 None
 0.62A 1eqbD-3n0lA:
56.7		 1eqbD-3n0lA:
54.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om3 CYTOCHROME C OXIDASE
SUBUNIT 2

(Rhodobacter
sphaeroides) 		PF00116
(COX2)
PF02790
(COX2_TM) 		3 GLU B 189
TYR B 185
PHE B 249
 None
 0.95A 1eqbD-3om3B:
undetectable		 1eqbD-3om3B:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2x HB36.3, DESIGNED
HEMAGGLUTININ
BINDING PROTEIN

(synthetic
construct) 		PF08958
(DUF1871) 		3 GLU C  34
TYR C  31
PHE C  63
 None
 0.52A 1eqbD-3r2xC:
undetectable		 1eqbD-3r2xC:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		3 GLU A 171
TYR A 169
PHE A 211
 None
 0.86A 1eqbD-3s69A:
undetectable		 1eqbD-3s69A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		3 GLU A 478
TYR A 316
PHE A 415
 None
 0.85A 1eqbD-3thcA:
undetectable		 1eqbD-3thcA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnx PAPAIN

(Carica papaya) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 GLU A 157
TYR A 195
PHE A 135
 None
 0.87A 1eqbD-3tnxA:
undetectable		 1eqbD-3tnxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0f LAMININ-BINDING
SURFACE PROTEIN

(Streptococcus
agalactiae) 		PF01297
(ZnuA) 		3 GLU A  48
TYR A 290
PHE A 179
 None
 0.96A 1eqbD-4h0fA:
undetectable		 1eqbD-4h0fA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hd1 SQUALENE SYNTHASE
HPNC

(Alicyclobacillus
acidocaldarius) 		PF00494
(SQS_PSY) 		3 GLU A  72
TYR A  69
PHE A  86
 None
 0.89A 1eqbD-4hd1A:
undetectable		 1eqbD-4hd1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huh TAIL CONNECTOR
PROTEIN GP15

(Escherichia
virus T4) 		PF16724
(T4-gp15_tss) 		3 GLU A 151
TYR A 109
PHE A 153
 None
 0.94A 1eqbD-4huhA:
undetectable		 1eqbD-4huhA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnh GAG POLYPROTEIN

(Simian foamy
virus) 		PF03276
(Gag_spuma) 		3 GLU A  49
TYR A 123
PHE A  51
 None
 0.92A 1eqbD-4jnhA:
undetectable		 1eqbD-4jnhA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 GLU A 334
TYR A 341
PHE A 330
 None
 0.75A 1eqbD-4kxbA:
undetectable		 1eqbD-4kxbA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 GLU A 539
TYR A 790
PHE A  33
 None
 0.92A 1eqbD-4lglA:
17.8		 1eqbD-4lglA:
18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		3 GLU A  56
TYR A  63
PHE A 266
 None
 0.62A 1eqbD-4o6zA:
55.6		 1eqbD-4o6zA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Psychromonas
ingrahamii) 		PF00464
(SHMT) 		3 GLU A  57
TYR A  64
PHE A 257
 None
 0.35A 1eqbD-4p3mA:
47.2		 1eqbD-4p3mA:
74.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN

(Vibrio cholerae) 		no annotation 3 GLU E 155
TYR E 153
PHE E 183
 None
 0.88A 1eqbD-4p9uE:
undetectable		 1eqbD-4p9uE:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgw UNCHARACTERIZED
PROTEIN YETJ

(Bacillus
subtilis) 		PF01027
(Bax1-I) 		3 GLU A  99
TYR A  95
PHE A 207
 None
 0.80A 1eqbD-4pgwA:
undetectable		 1eqbD-4pgwA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmz XYLANASE

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		3 GLU A 226
TYR A 190
PHE A 225
 None
 0.83A 1eqbD-4pmzA:
undetectable		 1eqbD-4pmzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhb UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		3 GLU A 374
TYR A 281
PHE A 312
 None
 0.96A 1eqbD-4qhbA:
undetectable		 1eqbD-4qhbA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhx UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF11958
(DUF3472)
PF16871
(DUF5077) 		3 GLU A 322
TYR A 191
PHE A 324
 SO4  A 508 (-3.6A)
None
PEG  A 520 (-3.7A)
 0.97A 1eqbD-4qhxA:
undetectable		 1eqbD-4qhxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		3 GLU A 462
TYR A 458
PHE A 446
 None
 0.92A 1eqbD-4qwwA:
undetectable		 1eqbD-4qwwA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urq DIGUANYLATE CYCLASE

(Thermotoga
maritima) 		PF00990
(GGDEF) 		3 GLU U 170
TYR U 166
PHE U 124
 None
 0.79A 1eqbD-4urqU:
undetectable		 1eqbD-4urqU:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urs DIGUANYLATE CYCLASE

(Thermotoga
maritima) 		PF00990
(GGDEF) 		3 GLU A 170
TYR A 166
PHE A 124
 GLU  A 170 ( 0.6A)
TYR  A 166 ( 1.3A)
PHE  A 124 ( 1.3A)
 0.92A 1eqbD-4ursA:
undetectable		 1eqbD-4ursA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		3 GLU A 945
TYR A1017
PHE A 941
 None
 0.96A 1eqbD-4uvkA:
undetectable		 1eqbD-4uvkA:
18.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		3 GLU A  51
TYR A  58
PHE A 250
 None
 0.71A 1eqbD-4wxbA:
59.0		 1eqbD-4wxbA:
58.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		3 GLU A 460
TYR A 456
PHE A 444
 None
 0.89A 1eqbD-4xiiA:
undetectable		 1eqbD-4xiiA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 GLU A  45
TYR A  42
PHE A 460
 None
 0.95A 1eqbD-5brqA:
undetectable		 1eqbD-5brqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e76 SUSD-LIKE PROTEIN
BACOVA_02651

(Bacteroides
ovatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 GLU A 445
TYR A 383
PHE A 261
 None
 0.77A 1eqbD-5e76A:
undetectable		 1eqbD-5e76A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 GLU A 210
TYR A 238
PHE A 212
 None
 0.68A 1eqbD-5f7cA:
undetectable		 1eqbD-5f7cA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Ureibacillus
thermosphaericus) 		PF01113
(DapB_N)
PF16654
(DAPDH_C) 		3 GLU A 200
TYR A 172
PHE A 202
 None
 0.73A 1eqbD-5gz1A:
2.3		 1eqbD-5gz1A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE

(Medicago
truncatula) 		PF00795
(CN_hydrolase) 		3 GLU A  96
TYR A  70
PHE A  94
 None
 0.75A 1eqbD-5h8kA:
undetectable		 1eqbD-5h8kA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		3 GLU A 226
TYR A 224
PHE A 239
 None
 0.69A 1eqbD-5l2rA:
undetectable		 1eqbD-5l2rA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		3 GLU A 384
TYR A 380
PHE A 390
 None
 0.67A 1eqbD-5n6mA:
undetectable		 1eqbD-5n6mA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td3 CATECHOL
1,2-DIOXYGENASE

(Burkholderia
vietnamiensis) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 GLU A 117
TYR A 121
PHE A 239
 None
 0.73A 1eqbD-5td3A:
undetectable		 1eqbD-5td3A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umh CATECHOL
1,2-DIOXYGENASE

(Burkholderia
multivorans) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 GLU A 106
TYR A 110
PHE A 228
 None
 0.75A 1eqbD-5umhA:
undetectable		 1eqbD-5umhA:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 GLU A  98
TYR A 105
PHE A 320
 None
 0.46A 1eqbD-5v7iA:
51.3		 1eqbD-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		3 GLU A  56
TYR A  63
PHE A 256
 None
 0.85A 1eqbD-5vmbA:
57.3		 1eqbD-5vmbA:
71.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrk AP-2 COMPLEX SUBUNIT
MU

(Rattus
norvegicus) 		no annotation 3 GLU A 172
TYR A 205
PHE A 174
 None
NI  A 502 (-4.8A)
NI  A 502 ( 4.0A)
 0.75A 1eqbD-5wrkA:
undetectable		 1eqbD-5wrkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrl AP-2 COMPLEX SUBUNIT
MU

(Rattus
norvegicus) 		no annotation 3 GLU A 172
TYR A 205
PHE A 174
 None
 0.78A 1eqbD-5wrlA:
undetectable		 1eqbD-5wrlA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
vivax) 		no annotation 3 GLU A  56
TYR A  63
PHE A 266
 None
 0.31A 1eqbD-5xmrA:
56.8		 1eqbD-5xmrA:
40.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yc1 TNF
RECEPTOR-ASSOCIATED
FACTOR 4

(Homo sapiens) 		no annotation 3 GLU A 331
TYR A 366
PHE A 351
 None
 0.85A 1eqbD-5yc1A:
undetectable		 1eqbD-5yc1A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq0 COFJ

(Escherichia
coli) 		no annotation 3 GLU A 158
TYR A  86
PHE A 160
 None
 0.94A 1eqbD-5yq0A:
undetectable		 1eqbD-5yq0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 3 GLU A 141
TYR A 139
PHE A 180
 EQG  A 504 (-2.0A)
EQG  A 504 (-3.2A)
EQG  A 504 (-3.1A)
 0.96A 1eqbD-6c4gA:
undetectable		 1eqbD-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 3 GLU A 136
TYR A 143
PHE A 349
 None
 0.21A 1eqbD-6cczA:
56.9		 1eqbD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 3 GLU A 366
TYR A 362
PHE A  52
 None
 0.83A 1eqbD-6f8zA:
undetectable		 1eqbD-6f8zA:
undetectable