SIMILAR PATTERNS OF AMINO ACIDS FOR 1EQB_C_FFOC3293_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6j NITROGEN REGULATORY
IIA PROTEIN

(Escherichia
coli) 		PF00359
(PTS_EIIA_2) 		3 SER A  36
GLU A  37
GLU A  33
 None
 0.69A 1eqbB-1a6jA:
undetectable		 1eqbB-1a6jA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a76 FLAP ENDONUCLEASE-1
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 SER A 151
GLU A 152
GLU A  88
 None
MN  A 340 ( 4.3A)
None
 0.72A 1eqbB-1a76A:
0.7		 1eqbB-1a76A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		3 SER A 293
GLU A 294
GLU A 295
 None
 0.69A 1eqbB-1d2rA:
1.6		 1eqbB-1d2rA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e25 EXTENDED-SPECTRUM
BETA-LACTAMASE PER-1

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		3 SER A  35
GLU A  34
GLU A  31
 None
 0.61A 1eqbB-1e25A:
0.0		 1eqbB-1e25A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF01180
(DHO_dh) 		3 SER A 223
GLU A 224
GLU A 225
 None
 0.54A 1eqbB-1f76A:
1.3		 1eqbB-1f76A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fml RETINOL DEHYDRATASE

(Spodoptera
frugiperda) 		PF00685
(Sulfotransfer_1) 		3 SER A 271
GLU A 272
GLU A 273
 None
 0.46A 1eqbB-1fmlA:
0.0		 1eqbB-1fmlA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus) 		PF00079
(Serpin) 		3 SER A 336
GLU A 294
GLU A 295
 None
 0.60A 1eqbB-1hleA:
undetectable		 1eqbB-1hleA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7h FERREDOXIN

(Escherichia
coli) 		PF00111
(Fer2) 		3 SER A  83
GLU A  82
GLU A  80
 None
 0.62A 1eqbB-1i7hA:
undetectable		 1eqbB-1i7hA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioj APOC-I

(Homo sapiens) 		PF04691
(ApoC-I) 		3 SER A  43
GLU A  44
GLU A  40
 None
 0.59A 1eqbB-1iojA:
undetectable		 1eqbB-1iojA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 SER A 123
GLU A 124
GLU A 125
 None
 0.66A 1eqbB-1l0wA:
1.1		 1eqbB-1l0wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)

(Homo sapiens) 		PF00681
(Plectin) 		3 SER A2402
GLU A2403
GLU A2399
 None
 0.70A 1eqbB-1lm7A:
undetectable		 1eqbB-1lm7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		3 SER A 107
GLU A 108
GLU A 109
 None
 0.56A 1eqbB-1lxyA:
undetectable		 1eqbB-1lxyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ntg TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF01588
(tRNA_bind) 		3 SER A 140
GLU A 141
GLU A 142
 None
 0.62A 1eqbB-1ntgA:
undetectable		 1eqbB-1ntgA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM

(Canis lupus) 		PF01216
(Calsequestrin) 		3 SER A 154
GLU A 155
GLU A 156
 None
 0.60A 1eqbB-1sjiA:
undetectable		 1eqbB-1sjiA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqi 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Rattus
norvegicus) 		PF00903
(Glyoxalase) 		3 SER A 235
GLU A 234
GLU A 233
 None
 0.62A 1eqbB-1sqiA:
undetectable		 1eqbB-1sqiA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli) 		PF02541
(Ppx-GppA) 		3 SER A  58
GLU A  59
GLU A  60
 None
 0.67A 1eqbB-1u6zA:
undetectable		 1eqbB-1u6zA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli) 		PF02541
(Ppx-GppA) 		3 SER A 264
GLU A 265
GLU A 266
 SO4  A 703 (-2.7A)
None
None
 0.52A 1eqbB-1u6zA:
undetectable		 1eqbB-1u6zA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT

(Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 SER A 297
GLU A 298
GLU A 294
 None
 0.68A 1eqbB-1uliA:
undetectable		 1eqbB-1uliA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		3 SER C 199
GLU C 198
GLU C 195
 None
 0.67A 1eqbB-1w36C:
undetectable		 1eqbB-1w36C:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlh GELATION FACTOR

(Dictyostelium
discoideum) 		PF00630
(Filamin) 		3 SER A 570
GLU A 616
GLU A 618
 None
 0.53A 1eqbB-1wlhA:
undetectable		 1eqbB-1wlhA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl3 SECRETION CONTROL
PROTEIN

(Yersinia pestis) 		PF07201
(HrpJ) 		3 SER A 129
GLU A 130
GLU A 131
 MLY  A 128 ( 4.0A)
None
None
 0.68A 1eqbB-1xl3A:
undetectable		 1eqbB-1xl3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm5 HYPOTHETICAL UPF0054
PROTEIN YBEY

(Escherichia
coli) 		PF02130
(UPF0054) 		3 SER A1022
GLU A1021
GLU A1020
 None
 0.69A 1eqbB-1xm5A:
undetectable		 1eqbB-1xm5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE

(Archaeoglobus
fulgidus) 		PF12840
(HTH_20) 		3 SER A  43
GLU A  44
GLU A  45
 None
 0.58A 1eqbB-1y0uA:
undetectable		 1eqbB-1y0uA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y88 HYPOTHETICAL PROTEIN
AF1548

(Archaeoglobus
fulgidus) 		PF04471
(Mrr_cat) 		3 SER A  93
GLU A  94
GLU A  95
 SO4  A 301 (-2.5A)
None
None
 0.51A 1eqbB-1y88A:
undetectable		 1eqbB-1y88A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		3 SER A  81
GLU A  82
GLU A  83
 None
 0.57A 1eqbB-1ztvA:
undetectable		 1eqbB-1ztvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9j BISPHOSPHOGLYCERATE
MUTASE

(Homo sapiens) 		PF00300
(His_Phos_1) 		3 SER A 129
GLU A 128
GLU A 127
 None
 0.55A 1eqbB-2a9jA:
undetectable		 1eqbB-2a9jA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atf CYSTEINE DIOXYGENASE
TYPE I

(Mus musculus) 		PF05995
(CDO_I) 		3 SER A 146
GLU A  79
GLU A 149
 None
 0.71A 1eqbB-2atfA:
undetectable		 1eqbB-2atfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crq MITOCHONDRIAL
TRANSLATIONAL
INITIATION FACTOR 3

(Mus musculus) 		PF00707
(IF3_C) 		3 SER A  59
GLU A  62
GLU A  61
 None
 0.71A 1eqbB-2crqA:
undetectable		 1eqbB-2crqA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4r HYPOTHETICAL PROTEIN
TTHA0849

(Thermus
thermophilus) 		PF03364
(Polyketide_cyc) 		3 SER A  79
GLU A  65
GLU A  81
 None
 0.66A 1eqbB-2d4rA:
undetectable		 1eqbB-2d4rA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dcp HYPOTHETICAL PROTEIN
(RAFL09-17-B18)

(Arabidopsis
thaliana) 		PF01417
(ENTH) 		3 SER A  51
GLU A  52
GLU A  87
 None
 0.68A 1eqbB-2dcpA:
undetectable		 1eqbB-2dcpA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqz R.ECL18KI

(Enterobacter
cloacae) 		PF09019
(EcoRII-C) 		3 SER A 214
GLU A 215
GLU A 216
 None
 0.61A 1eqbB-2fqzA:
undetectable		 1eqbB-2fqzA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE

(Mus musculus) 		PF02485
(Branch) 		3 SER A 161
GLU A 160
GLU A 159
 None
 0.55A 1eqbB-2gamA:
undetectable		 1eqbB-2gamA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfg BH2851

(Bacillus
halodurans) 		PF01928
(CYTH) 		3 SER A 156
GLU A 157
GLU A 158
 EDO  A 504 (-4.6A)
None
None
 0.56A 1eqbB-2gfgA:
undetectable		 1eqbB-2gfgA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpa PROTEIN (ACID
PHOSPHATASE)

(Homo sapiens) 		PF00328
(His_Phos_2) 		3 SER A1142
GLU A1143
GLU A1144
 None
 0.59A 1eqbB-2hpaA:
undetectable		 1eqbB-2hpaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE

(Renilla
reniformis) 		PF00561
(Abhydrolase_1) 		3 SER A 168
GLU A 169
GLU A 170
 None
 0.58A 1eqbB-2psfA:
undetectable		 1eqbB-2psfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7c ORPHAN NUCLEAR
RECEPTOR NR1D2

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 SER A 569
GLU A 571
GLU A 570
 None
 0.62A 1eqbB-2v7cA:
undetectable		 1eqbB-2v7cA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3

(Homo sapiens) 		PF00226
(DnaJ)
PF09976
(TPR_21)
PF13181
(TPR_8) 		3 SER A 317
GLU A 320
GLU A 348
 None
 0.68A 1eqbB-2y4tA:
undetectable		 1eqbB-2y4tA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ag6 PANTOTHENATE
SYNTHETASE

(Staphylococcus
aureus) 		PF02569
(Pantoate_ligase) 		3 SER A  84
GLU A  85
GLU A  81
 None
 0.67A 1eqbB-3ag6A:
undetectable		 1eqbB-3ag6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		3 SER A  18
GLU A  19
GLU A  20
 None
 0.61A 1eqbB-3al0A:
undetectable		 1eqbB-3al0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdk D-MANNONATE
DEHYDRATASE

(Streptococcus
suis) 		PF03786
(UxuA) 		3 SER A 190
GLU A 191
GLU A 192
 None
 0.64A 1eqbB-3bdkA:
undetectable		 1eqbB-3bdkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3v ARACHIN ARAH3
ISOFORM

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		3 SER A 292
GLU A 293
GLU A 294
 None
 0.66A 1eqbB-3c3vA:
undetectable		 1eqbB-3c3vA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4e PUTATIVE
BETA-LACTAMASE
INHIBITOR PROTEIN

(Streptococcus
mutans) 		PF12978
(DUF3862) 		3 SER A 163
GLU A 169
GLU A 170
 ACT  A   1 (-2.7A)
None
None
 0.58A 1eqbB-3d4eA:
undetectable		 1eqbB-3d4eA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efx CHOLERA ENTEROTOXIN
SUBUNIT B,
HEAT-LABILE
ENTEROTOXIN B CHAIN

(Escherichia
coli;
Vibrio cholerae) 		PF01376
(Enterotoxin_b) 		3 SER D  10
GLU D  11
GLU D   7
 None
 0.71A 1eqbB-3efxD:
undetectable		 1eqbB-3efxD:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 SER A 833
GLU A 832
GLU A 829
 None
 0.71A 1eqbB-3ho8A:
undetectable		 1eqbB-3ho8A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv1 POLAR AMINO ACID ABC
UPTAKE TRANSPORTER
SUBSTRATE BINDING
PROTEIN

(Streptococcus
thermophilus) 		PF00497
(SBP_bac_3) 		3 SER A  65
GLU A  60
GLU A  61
 None
 0.65A 1eqbB-3hv1A:
undetectable		 1eqbB-3hv1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 ALPHA-SOLUBLE NSF
ATTACHMENT PROTEIN

(Rattus
norvegicus) 		no annotation 3 SER H 157
GLU H 156
GLU H 155
 None
 0.34A 1eqbB-3j97H:
undetectable		 1eqbB-3j97H:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv9 PUTATIVE TRANSPORTER

(Clostridioides
difficile) 		PF00571
(CBS) 		3 SER A  40
GLU A  41
GLU A  42
 None
 0.68A 1eqbB-3lv9A:
undetectable		 1eqbB-3lv9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyp STRINGENT STARVATION
PROTEIN A

(Pseudomonas
protegens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 SER A 151
GLU A 152
GLU A 153
 None
 0.49A 1eqbB-3lypA:
undetectable		 1eqbB-3lypA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 SER A  23
GLU A  22
GLU A  21
 None
 0.68A 1eqbB-3nx4A:
undetectable		 1eqbB-3nx4A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orj SUGAR-BINDING
PROTEIN

(Bacteroides
ovatus) 		no annotation 3 SER A 201
GLU A 202
GLU A 203
 None
 0.55A 1eqbB-3orjA:
undetectable		 1eqbB-3orjA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pef 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING

(Geobacter
metallireducens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 SER A  57
GLU A  56
GLU A  53
 None
 0.69A 1eqbB-3pefA:
2.6		 1eqbB-3pefA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prh TRYPTOPHANYL-TRNA
SYNTHETASE

(Bacillus
subtilis) 		PF00579
(tRNA-synt_1b) 		3 SER A 294
GLU A 295
GLU A 296
 None
 0.68A 1eqbB-3prhA:
undetectable		 1eqbB-3prhA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi) 		PF04264
(YceI) 		3 SER A  69
GLU A  68
GLU A  66
 None
 0.67A 1eqbB-3q34A:
undetectable		 1eqbB-3q34A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwb PROBABLE QUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 SER A 107
GLU A  37
GLU A  36
 None
 0.71A 1eqbB-3qwbA:
3.4		 1eqbB-3qwbA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		3 SER A 196
GLU A 197
GLU A 198
 None
FAD  A 232 ( 3.9A)
None
 0.70A 1eqbB-3te7A:
undetectable		 1eqbB-3te7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7b UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF09449
(DUF2020) 		3 SER A  75
GLU A  76
GLU A  77
 None
 0.72A 1eqbB-3v7bA:
undetectable		 1eqbB-3v7bA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1e FLAGELLA BASAL-BODY
PROTEIN

(Vibrio
alginolyticus) 		PF16538
(FlgT_C)
PF16539
(FlgT_M)
PF16548
(FlgT_N) 		3 SER A  14
GLU A  15
GLU A  16
 None
 0.57A 1eqbB-3w1eA:
undetectable		 1eqbB-3w1eA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wva UPF0254 PROTEIN
MJ1251

(Methanocaldococcus
jannaschii) 		PF06787
(UPF0254) 		3 SER A  36
GLU A  37
GLU A  38
 None
 0.57A 1eqbB-3wvaA:
undetectable		 1eqbB-3wvaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		3 SER A 476
GLU A 477
GLU A 478
 None
 0.69A 1eqbB-3zgbA:
undetectable		 1eqbB-3zgbA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 SER A 320
GLU A 321
GLU A 322
 None
 0.43A 1eqbB-4a69A:
3.7		 1eqbB-4a69A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		3 SER A 498
GLU A 499
GLU A 495
 None
 0.54A 1eqbB-4e3cA:
undetectable		 1eqbB-4e3cA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN

(Arabidopsis
thaliana) 		PF00225
(Kinesin) 		3 SER A1072
GLU A1073
GLU A1069
 None
 0.67A 1eqbB-4frzA:
undetectable		 1eqbB-4frzA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcv PUTATIVE
TRANSCRIPTION
PROTEIN

(Pseudomonas
aeruginosa) 		PF01638
(HxlR) 		3 SER A 149
GLU A 150
GLU A 151
 None
 0.57A 1eqbB-4gcvA:
undetectable		 1eqbB-4gcvA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huj UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored) 		3 SER A 114
GLU A 115
GLU A 111
 None
 0.69A 1eqbB-4hujA:
undetectable		 1eqbB-4hujA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		3 SER A 185
GLU A 186
GLU A 187
 None
 0.68A 1eqbB-4i59A:
undetectable		 1eqbB-4i59A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE

(Toxoplasma
gondii) 		PF00316
(FBPase) 		3 SER A  87
GLU A  88
GLU A  89
 None
 0.34A 1eqbB-4ir8A:
undetectable		 1eqbB-4ir8A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3w ENOYL-COA
HYDRATASE/ISOMERASE

(Marinobacter
hydrocarbonoclasticus) 		PF00378
(ECH_1) 		3 SER A 195
GLU A 196
GLU A 197
 None
 0.49A 1eqbB-4k3wA:
undetectable		 1eqbB-4k3wA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh8 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF16103
(DUF4822) 		3 SER A  61
GLU A  62
GLU A  58
 None
 0.65A 1eqbB-4kh8A:
undetectable		 1eqbB-4kh8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l15 FIDGETIN-LIKE
PROTEIN 1

(Caenorhabditis
elegans) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 SER A 487
GLU A 486
GLU A 484
 None
 0.66A 1eqbB-4l15A:
undetectable		 1eqbB-4l15A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l18 RUNT-RELATED
TRANSCRIPTION FACTOR
1

(Mus musculus) 		PF00853
(Runt) 		3 SER A 199
GLU A 200
GLU A 196
 None
 0.72A 1eqbB-4l18A:
undetectable		 1eqbB-4l18A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		3 SER A 365
GLU A 367
GLU A 366
 None
 0.70A 1eqbB-4r70A:
undetectable		 1eqbB-4r70A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r80 OR486

(synthetic
construct) 		no annotation 3 SER A   2
GLU A   3
GLU A   4
 None
 0.57A 1eqbB-4r80A:
undetectable		 1eqbB-4r80A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlg SEC14-LIKE PROTEIN 4

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		3 SER A 210
GLU A 211
GLU A 212
 EDO  A 501 ( 4.6A)
None
None
 0.51A 1eqbB-4tlgA:
undetectable		 1eqbB-4tlgA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpv PLATELET INHIBITOR

(Ancylostoma
caninum) 		PF00188
(CAP) 		3 SER A  62
GLU A  63
GLU A  64
 None
 0.53A 1eqbB-4tpvA:
undetectable		 1eqbB-4tpvA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbp CAPRIN-1

(Homo sapiens) 		no annotation 3 SER A 179
GLU A 180
GLU A 181
 None
 0.54A 1eqbB-4wbpA:
undetectable		 1eqbB-4wbpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 SER A 171
GLU A 172
GLU A 173
 None
 0.68A 1eqbB-4woeA:
undetectable		 1eqbB-4woeA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		3 SER A 405
GLU A 406
GLU A 407
 None
 0.67A 1eqbB-4yr1A:
undetectable		 1eqbB-4yr1A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4

(Mus musculus) 		PF01852
(START) 		3 SER A  61
GLU A  62
GLU A  63
 None
 0.69A 1eqbB-5brlA:
undetectable		 1eqbB-5brlA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwj DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 3 SER A  62
GLU A  63
GLU A  64
 None
 0.66A 1eqbB-5cwjA:
undetectable		 1eqbB-5cwjA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		3 SER A  85
GLU A  86
GLU A  87
 None
 0.70A 1eqbB-5fifA:
undetectable		 1eqbB-5fifA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		3 SER A1143
GLU A1144
GLU A1145
 None
 0.63A 1eqbB-5gjvA:
undetectable		 1eqbB-5gjvA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN

(Zika virus) 		PF00948
(Flavi_NS1) 		3 SER A 239
GLU A 238
GLU A 237
 None
 0.63A 1eqbB-5gs6A:
undetectable		 1eqbB-5gs6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4r BETA-1,3-1,4-GLUCANA
SE

(Caldicellulosiruptor
sp. F32) 		PF00150
(Cellulase) 		3 SER A 297
GLU A 298
GLU A 299
 None
 0.50A 1eqbB-5h4rA:
undetectable		 1eqbB-5h4rA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy3 MRNA
ENDORIBONUCLEASE
LSOA

(Escherichia
coli) 		PF15935
(RnlA_toxin) 		3 SER A 112
GLU A 113
GLU A 109
 None
 0.69A 1eqbB-5hy3A:
undetectable		 1eqbB-5hy3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 SER A  35
GLU A  36
GLU A  37
 None
 0.52A 1eqbB-5k3jA:
undetectable		 1eqbB-5k3jA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjz CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT

(Homo sapiens) 		PF00027
(cNMP_binding) 		3 SER A 251
GLU A 247
GLU A 248
 None
 0.71A 1eqbB-5kjzA:
undetectable		 1eqbB-5kjzA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kku POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		3 SER A  69
GLU A  70
GLU A  71
 None
 0.58A 1eqbB-5kkuA:
undetectable		 1eqbB-5kkuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 SER A 464
GLU A 550
GLU A 552
 None
 0.56A 1eqbB-5m2nA:
undetectable		 1eqbB-5m2nA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9n TUDOR
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00567
(TUDOR) 		3 SER A 567
GLU A 568
GLU A 569
 None
None
EDO  A 701 ( 4.9A)
 0.59A 1eqbB-5m9nA:
undetectable		 1eqbB-5m9nA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 SER A 517
GLU A 518
GLU A 983
 None
 0.50A 1eqbB-5um6A:
undetectable		 1eqbB-5um6A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 3 SER A 159
GLU A 160
GLU A 156
 None
 0.65A 1eqbB-5w7qA:
undetectable		 1eqbB-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG

(Saccharomyces
cerevisiae) 		PF10345
(Cohesin_load) 		3 SER A  33
GLU A  34
GLU A  35
 None
 0.54A 1eqbB-5w94A:
undetectable		 1eqbB-5w94A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arr ACETYL-COA
ACETYLTRANSFERASE

(Aspergillus
fumigatus) 		no annotation 3 SER A  82
GLU A  81
GLU A  80
 None
 0.54A 1eqbB-6arrA:
undetectable		 1eqbB-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 3 SER A1143
GLU A1144
GLU A1145
 None
 0.61A 1eqbB-6byoA:
undetectable		 1eqbB-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB

(Rattus
norvegicus) 		no annotation 3 SER P 216
GLU P 217
GLU P 218
 None
 0.68A 1eqbB-6c1dP:
undetectable		 1eqbB-6c1dP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwo RIBONUCLEOTIDE
REDUCTASE

(Flavobacterium
johnsoniae) 		no annotation 3 SER A 251
GLU A 250
GLU A  52
 None
 0.69A 1eqbB-6cwoA:
undetectable		 1eqbB-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama) 		no annotation 3 SER A   7
GLU A   6
GLU A   5
 None
 0.61A 1eqbB-6dbeA:
undetectable		 1eqbB-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 3 SER D 414
GLU D 415
GLU D 416
 None
 0.56A 1eqbB-6fkhD:
undetectable		 1eqbB-6fkhD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 3 SER A 464
GLU A 465
GLU A 466
 None
 0.63A 1eqbB-6gnfA:
undetectable		 1eqbB-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6guo -

(-) 		no annotation 3 SER A 262
GLU A 263
GLU A 259
 None
 0.63A 1eqbB-6guoA:
undetectable		 1eqbB-6guoA:
undetectable