SIMILAR PATTERNS OF AMINO ACIDS FOR 1EPB_B_9CRB165

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 0.89A 1epbB-1d6hA:
0.0		 1epbB-1d6hA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 387
LEU A 375
VAL A 229
ILE A  24
ILE A  27
 None
 0.95A 1epbB-1ee0A:
0.0		 1epbB-1ee0A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji0 ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 PHE A 125
VAL A  85
VAL A 180
ILE A 181
ILE A  33
 None
 0.93A 1epbB-1ji0A:
undetectable		 1epbB-1ji0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A 500
VAL A 210
LEU A 443
ALA A 226
ILE A 474
 None
 0.98A 1epbB-1knrA:
0.0		 1epbB-1knrA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktj ALLERGEN DER P 2

(Dermatophagoides
pteronyssinus) 		PF02221
(E1_DerP2_DerF2) 		6 ILE A  29
LEU A  37
VAL A  65
ALA A  56
ILE A  54
ILE A  52
 None
 1.30A 1epbB-1ktjA:
undetectable		 1epbB-1ktjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktj ALLERGEN DER P 2

(Dermatophagoides
pteronyssinus) 		PF02221
(E1_DerP2_DerF2) 		5 LEU A  37
VAL A 110
ALA A  72
ILE A  52
ILE A  54
 None
 0.90A 1epbB-1ktjA:
undetectable		 1epbB-1ktjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 LEU A 339
VAL A 252
ALA A 234
ILE A 306
ILE A 259
 None
 0.96A 1epbB-1lbqA:
0.0		 1epbB-1lbqA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leh LEUCINE
DEHYDROGENASE

(Lysinibacillus
sphaericus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ILE A 286
LEU A 188
VAL A 255
ALA A 162
ILE A 233
 None
 1.02A 1epbB-1lehA:
0.0		 1epbB-1lehA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ILE A 116
VAL A  63
ALA A  30
ILE A  32
ILE A 131
 None
None
None
None
NAD  A5500 (-3.9A)
 0.93A 1epbB-1m2wA:
0.0		 1epbB-1m2wA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 PHE A 193
ILE A  60
VAL A 272
ILE A 273
ILE A 277
 None
 1.03A 1epbB-1nj1A:
undetectable		 1epbB-1nj1A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		5 PHE A 177
ILE A  43
VAL A 256
ILE A 257
ILE A 261
 None
 1.02A 1epbB-1nj8A:
undetectable		 1epbB-1nj8A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A1012
VAL A1033
ALA A1053
ILE A1056
ILE A1058
 None
 0.89A 1epbB-1ofeA:
undetectable		 1epbB-1ofeA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A  72
VAL A   5
LEU A  23
ALA A  79
ILE A  81
 None
 1.02A 1epbB-1p43A:
undetectable		 1epbB-1p43A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		5 ILE A  41
LEU A 105
VAL A  38
ALA A  47
ILE A  57
 None
 1.00A 1epbB-1pe9A:
undetectable		 1epbB-1pe9A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00117
(GATase) 		5 ILE B  31
LEU B  49
VAL B  14
ALA B  18
ILE B  17
 None
 1.01A 1epbB-1qdlB:
undetectable		 1epbB-1qdlB:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvi HYPOTHETICAL UPF0054
PROTEIN TM1509

(Thermotoga
maritima) 		PF02130
(UPF0054) 		5 VAL A 133
LEU A  17
VAL A  34
ILE A   2
ILE A   4
 None
 1.04A 1epbB-1tviA:
undetectable		 1epbB-1tviA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 385
LEU A 373
VAL A 227
ILE A  21
ILE A  24
 None
 0.80A 1epbB-1u0uA:
undetectable		 1epbB-1u0uA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uit HUMAN DISCS LARGE 5
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A  49
VAL A  23
ALA A  97
ILE A  95
ILE A  93
 None
 0.85A 1epbB-1uitA:
undetectable		 1epbB-1uitA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE

(Sulfurisphaera
tokodaii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A  28
LYS A  97
VAL A  71
ALA A  89
ILE A  92
 None
 0.96A 1epbB-1wydA:
undetectable		 1epbB-1wydA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptococcus
pneumoniae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 ILE A 205
VAL A  63
LEU A  60
ILE A 196
ILE A 262
 None
 1.01A 1epbB-1xp4A:
undetectable		 1epbB-1xp4A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwv DER F II

(Dermatophagoides
farinae) 		PF02221
(E1_DerP2_DerF2) 		6 ILE A  29
LEU A  37
VAL A  65
ALA A  56
ILE A  54
ILE A  52
 None
PE3  A1001 (-4.5A)
PE3  A1001 ( 4.0A)
PE3  A1001 ( 4.1A)
PE3  A1001 (-4.8A)
PE3  A1001 ( 4.3A)
 1.12A 1epbB-1xwvA:
undetectable		 1epbB-1xwvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N

(Mus musculus) 		PF00079
(Serpin) 		5 PHE A  54
ILE A  78
VAL A 355
LEU A 205
ILE A  97
 None
 0.88A 1epbB-1yxaA:
undetectable		 1epbB-1yxaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af4 PHOSPHATE
ACETYLTRANSFERASE

(Methanosarcina
thermophila) 		PF01515
(PTA_PTB) 		5 ILE C 249
VAL C 156
ALA C 285
ILE C 154
ILE C 153
 None
CSO  C 159 ( 4.2A)
None
None
None
 1.03A 1epbB-2af4C:
undetectable		 1epbB-2af4C:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czt PROSTAGLANDIN-H2
D-ISOMERASE

(Mus musculus) 		PF00061
(Lipocalin) 		6 PHE A  34
TRP A  43
VAL A  69
LEU A  79
VAL A 120
ALA A 129
 None
 0.66A 1epbB-2cztA:
18.5		 1epbB-2cztA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czt PROSTAGLANDIN-H2
D-ISOMERASE

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  34
VAL A  69
LEU A  79
VAL A 120
ALA A 123
 None
 0.99A 1epbB-2cztA:
18.5		 1epbB-2cztA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 VAL A 272
VAL A 316
ALA A 288
ILE A 285
ILE A 309
 None
 0.94A 1epbB-2e4uA:
undetectable		 1epbB-2e4uA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 ILE A 188
VAL A 217
LEU A 221
ILE A  61
ILE A  74
 None
 0.92A 1epbB-2gouA:
undetectable		 1epbB-2gouA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE

(Aedes aegypti) 		PF00266
(Aminotran_5) 		5 VAL A 166
LEU A 177
VAL A 123
ALA A 139
ILE A  97
 None
 1.03A 1epbB-2hufA:
undetectable		 1epbB-2hufA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j67 TOLL LIKE RECEPTOR
10

(Homo sapiens) 		PF01582
(TIR) 		5 LEU A 656
LYS A 691
VAL A 695
ILE A 728
ILE A 726
 None
 1.02A 1epbB-2j67A:
undetectable		 1epbB-2j67A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		5 ILE A 140
LEU A 184
VAL A 135
ALA A 146
ILE A 108
 None
 1.04A 1epbB-2nmpA:
undetectable		 1epbB-2nmpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum) 		PF01979
(Amidohydro_1) 		5 PHE A  14
VAL A  69
VAL A  38
ALA A 401
ILE A  44
 None
 0.99A 1epbB-2p9bA:
undetectable		 1epbB-2p9bA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1

(Streptococcus
agalactiae) 		PF13672
(PP2C_2) 		5 ILE A   3
LEU A 181
ARG A 125
VAL A 189
ILE A 121
 None
 1.00A 1epbB-2pk0A:
undetectable		 1epbB-2pk0A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A 977
VAL A 998
ALA A1018
ILE A1021
ILE A1023
 None
 0.92A 1epbB-2vdcA:
undetectable		 1epbB-2vdcA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		6 ILE A 299
LEU A 293
VAL A 348
ALA A 317
ILE A 318
ILE A 357
 None
 1.31A 1epbB-2vk9A:
undetectable		 1epbB-2vk9A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcv L-FUCOSE MUTAROTASE

(Escherichia
coli) 		PF05025
(RbsD_FucU) 		6 PHE A  28
ILE A  57
LEU A  14
VAL A 121
ALA A  45
ILE A  43
 None
 1.25A 1epbB-2wcvA:
undetectable		 1epbB-2wcvA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1

(Homo sapiens) 		PF02144
(Rad1) 		5 ILE C  65
LEU C  93
ALA C  40
ILE C  84
ILE C 134
 None
 1.02A 1epbB-3a1jC:
undetectable		 1epbB-3a1jC:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etu PROTEIN TRANSPORT
PROTEIN DSL1

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		5 PHE A 284
ILE A 310
VAL A 288
ILE A 295
ILE A 294
 None
 0.90A 1epbB-3etuA:
undetectable		 1epbB-3etuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etv PROTEIN TRANSPORT
PROTEIN TIP20,
PROTEIN TRANSPORT
PROTEIN DSL1 CHIMERA

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		5 PHE A 296
ILE A 322
VAL A 300
ILE A 307
ILE A 306
 None
 0.93A 1epbB-3etvA:
undetectable		 1epbB-3etvA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		5 LEU A 260
VAL A 125
ALA A 129
ILE A 128
ILE A 291
 None
 1.02A 1epbB-3hc1A:
undetectable		 1epbB-3hc1A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Thermoanaerobacter
pseudethanolicus) 		PF00724
(Oxidored_FMN) 		5 PHE A 195
ILE A 141
VAL A  61
ILE A 162
ILE A 213
 None
 0.95A 1epbB-3krzA:
undetectable		 1epbB-3krzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 ILE A 231
VAL A 274
LEU A 275
ALA A 245
ILE A 199
 None
 1.03A 1epbB-3m07A:
undetectable		 1epbB-3m07A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n92 ALPHA-AMYLASE, GH57
FAMILY

(Thermococcus
kodakarensis) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 PHE A 172
LEU A  41
VAL A 138
ILE A  58
ILE A  56
 None
 0.96A 1epbB-3n92A:
undetectable		 1epbB-3n92A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ALA A  17
ILE A 236
 None
 0.93A 1epbB-3ov3A:
undetectable		 1epbB-3ov3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 0.94A 1epbB-3ov3A:
undetectable		 1epbB-3ov3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		6 ILE A 160
VAL A 157
VAL A 189
ALA A 191
ILE A   9
ILE A  32
 None
FAD  A 601 (-4.1A)
None
None
None
None
 1.47A 1epbB-3p4sA:
undetectable		 1epbB-3p4sA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL

(Homo sapiens) 		PF00271
(Helicase_C)
PF12513
(SUV3_C) 		5 PHE A 373
ILE A 459
LEU A 498
VAL A 371
ILE A 438
 None
 1.04A 1epbB-3rc3A:
undetectable		 1epbB-3rc3A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		5 ILE A  68
LEU A 101
ALA A 140
ILE A 119
ILE A 121
 None
 1.04A 1epbB-3tlkA:
undetectable		 1epbB-3tlkA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		5 VAL A 969
LEU A 957
VAL A 811
ILE A 606
ILE A 609
 None
 0.89A 1epbB-3tsyA:
undetectable		 1epbB-3tsyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4y UNCHARACTERIZED
PROTEIN

(Desulfotomaculum
acetoxidans) 		PF10282
(Lactonase) 		5 ILE A 178
VAL A  98
ALA A 127
ILE A 123
ILE A 121
 None
 1.00A 1epbB-3u4yA:
undetectable		 1epbB-3u4yA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 PHE A  95
ILE A 102
VAL A  66
ILE A 150
ILE A  79
 None
 0.99A 1epbB-3v8vA:
undetectable		 1epbB-3v8vA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vml 3-ISOPROPYLMALATE
DEHYDROGENASE

(Shewanella
benthica;
Shewanella
oneidensis) 		PF00180
(Iso_dh) 		6 ILE A  36
LEU A  70
VAL A  28
ALA A 316
ILE A 320
ILE A 300
 None
 1.32A 1epbB-3vmlA:
undetectable		 1epbB-3vmlA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 VAL  A 382 ( 0.6A)
LEU  A 370 ( 0.5A)
VAL  A 224 ( 0.6A)
ILE  A  19 ( 0.7A)
ILE  A  22 ( 0.7A)
 0.83A 1epbB-3wd7A:
undetectable		 1epbB-3wd7A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 0.83A 1epbB-3wd8A:
undetectable		 1epbB-3wd8A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyf RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00638
(Ran_BP1) 		5 PHE B 274
ILE B 268
LEU B 222
VAL B 276
ILE B 290
 None
 0.99A 1epbB-3wyfB:
undetectable		 1epbB-3wyfB:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zc1 AFTRAX

(Archaeoglobus
fulgidus) 		PF01997
(Translin) 		5 PHE A 108
VAL A  82
ALA A  86
ILE A  85
ILE A  54
 None
 0.95A 1epbB-3zc1A:
undetectable		 1epbB-3zc1A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bws THIOREDOXIN-LIKE
PROTEIN 4A

(Homo sapiens) 		PF02966
(DIM1) 		5 PHE A  83
ILE A 115
VAL A  27
ALA A  56
ILE A  58
 None
 1.04A 1epbB-4bwsA:
undetectable		 1epbB-4bwsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c84 E3 UBIQUITIN-PROTEIN
LIGASE ZNRF3

(Danio rerio) 		no annotation 5 ILE A 128
VAL A  35
VAL A 168
ALA A 174
ILE A 167
 None
 0.96A 1epbB-4c84A:
undetectable		 1epbB-4c84A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8t E3 UBIQUITIN-PROTEIN
LIGASE ZNRF3

(Xenopus
tropicalis) 		no annotation 5 ILE A 128
VAL A  34
VAL A 168
ALA A 174
ILE A 167
 None
 0.86A 1epbB-4c8tA:
undetectable		 1epbB-4c8tA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdo THIOREDOXIN-LIKE
PROTEIN 4A,
POLYGLUTAMINE-BINDIN
G PROTEIN

(Homo sapiens) 		PF02966
(DIM1) 		5 PHE A  83
ILE A 115
VAL A  27
ALA A  56
ILE A  58
 None
 1.01A 1epbB-4cdoA:
undetectable		 1epbB-4cdoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LYS A  83
VAL A  87
ILE A  39
ILE A  41
LYS A  26
 None
 0.76A 1epbB-4d28A:
undetectable		 1epbB-4d28A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es7 PROTEIN AMBP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A   9
ILE A  11
VAL A  96
ALA A 105
LYS A 123
 None
 0.90A 1epbB-4es7A:
19.6		 1epbB-4es7A:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es7 PROTEIN AMBP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A   9
TRP A  18
VAL A  96
ALA A 105
LYS A 123
 None
 0.74A 1epbB-4es7A:
19.6		 1epbB-4es7A:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A  92
VAL A 130
VAL A 150
ALA A 201
ILE A 203
 None
 0.92A 1epbB-4f9oA:
undetectable		 1epbB-4f9oA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		5 VAL A 443
LEU A 415
ALA A 345
ILE A 346
ILE A 530
 None
 0.99A 1epbB-4fajA:
undetectable		 1epbB-4fajA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcu 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Acinetobacter
baumannii) 		PF02348
(CTP_transf_3) 		5 ILE A  29
VAL A  63
VAL A  97
ALA A  36
ILE A   4
 None
 1.03A 1epbB-4fcuA:
undetectable		 1epbB-4fcuA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdz SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C)
PF17210
(SdrD_B) 		5 PHE A 284
ILE A 272
LEU A 268
ALA A 320
ILE A 329
 None
 0.93A 1epbB-4jdzA:
undetectable		 1epbB-4jdzA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		5 ILE A 345
VAL A 381
LEU A 352
ILE A 324
ILE A 326
 None
 0.93A 1epbB-4jlcA:
undetectable		 1epbB-4jlcA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phb UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF14262
(Cthe_2159) 		6 ILE A 276
VAL A 252
VAL A 261
ALA A 245
ILE A 239
ILE A 208
 None
 1.35A 1epbB-4phbA:
undetectable		 1epbB-4phbA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		5 LEU B1327
VAL B1308
ALA B1314
ILE B1317
ILE B1286
 None
 0.97A 1epbB-4plbB:
undetectable		 1epbB-4plbB:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
DNA-DIRECTED RNA
POLYMERASE SUBUNIT H

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF01191
(RNA_pol_Rpb5_C)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE C  58
VAL A 860
ARG H  65
ALA C  68
ILE C 286
 None
 1.02A 1epbB-4qiwC:
undetectable		 1epbB-4qiwC:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 VAL A  58
LEU A  11
VAL A  28
ALA A 390
ILE A  33
 None
 0.87A 1epbB-4v1yA:
undetectable		 1epbB-4v1yA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 0.88A 1epbB-4wumA:
undetectable		 1epbB-4wumA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		5 PHE A 276
ILE A 241
LEU A 344
ALA A 217
ILE A 215
 None
 1.03A 1epbB-4zhtA:
undetectable		 1epbB-4zhtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		5 VAL A 367
LEU A 371
VAL A  14
ILE A 108
ILE A 106
 None
 1.03A 1epbB-4zhtA:
undetectable		 1epbB-4zhtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aju PHOSPHORIBOHYDROLASE
LONELY GUY

(Claviceps
purpurea) 		PF03641
(Lysine_decarbox) 		5 ILE A 177
TRP A 167
VAL A 139
ALA A 136
ILE A 140
 None
 0.91A 1epbB-5ajuA:
undetectable		 1epbB-5ajuA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		5 ILE A 731
VAL A 670
LEU A 672
ALA A 739
ILE A 690
 None
 1.03A 1epbB-5c1bA:
undetectable		 1epbB-5c1bA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 ILE A 264
VAL A 310
ALA A 338
ILE A 339
ILE A 317
 None
 0.97A 1epbB-5d6nA:
undetectable		 1epbB-5d6nA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		5 ILE A  84
VAL A 246
VAL A  72
ILE A  40
ILE A 342
 None
 1.03A 1epbB-5do7A:
undetectable		 1epbB-5do7A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewr BOX C/D SNORNP AND
U4 SNRNP COMPONENT
SNU13P

(Cyanidioschyzon
merolae) 		PF01248
(Ribosomal_L7Ae) 		6 PHE A  70
ILE A  39
ARG A 114
VAL A 121
ALA A  46
ILE A  52
 None
 1.46A 1epbB-5ewrA:
undetectable		 1epbB-5ewrA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 VAL A2138
LEU A2107
ALA A2133
ILE A2095
ILE A2090
 None
 1.03A 1epbB-5fbyA:
undetectable		 1epbB-5fbyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm5 MYOMESIN-1
OBSCURIN-LIKE-1

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		5 ILE O 248
VAL M 551
ALA M 604
ILE M 526
ILE M 528
 None
 0.96A 1epbB-5fm5O:
undetectable		 1epbB-5fm5O:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB

(Escherichia
coli) 		PF00072
(Response_reg) 		5 ILE A  19
VAL A   6
VAL A 107
ALA A 119
ILE A 103
 None
 1.00A 1epbB-5i4cA:
undetectable		 1epbB-5i4cA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ji5 BUPHA.10154.A.B1

(Paraburkholderia
phymatum) 		PF00850
(Hist_deacetyl) 		5 ILE A 159
LEU A 149
VAL A 281
ALA A 101
ILE A 109
 None
 1.03A 1epbB-5ji5A:
undetectable		 1epbB-5ji5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5klp ORF34

(Pseudomonas
syringae) 		PF03421
(Acetyltransf_14) 		5 ILE A 122
VAL A 197
LEU A 199
ALA A 154
ILE A 168
 None
 1.01A 1epbB-5klpA:
undetectable		 1epbB-5klpA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		5 PHE A  81
ARG A  72
VAL A 112
ALA A 132
ILE A  66
 None
 1.03A 1epbB-5l2pA:
1.3		 1epbB-5l2pA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 5 ILE A 468
LEU A 361
ALA A 475
ILE A 474
ILE A 567
 None
 0.95A 1epbB-5n6vA:
undetectable		 1epbB-5n6vA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 5 ILE B  97
LEU B 247
ALA B  45
ILE B  48
ILE B  50
 None
 1.01A 1epbB-5ofbB:
undetectable		 1epbB-5ofbB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-) 		no annotation 5 PHE A  46
ILE A 121
LEU A 328
VAL A 383
ILE A 360
 None
 0.99A 1epbB-5oieA:
undetectable		 1epbB-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		5 PHE A 402
ILE A 376
VAL A 373
LEU A 369
VAL A 404
 None
 0.98A 1epbB-5szsA:
undetectable		 1epbB-5szsA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1b MTRE
PROTEIN,FERRITIN
CHIMERA

(Helicobacter
pylori;
Neisseria
gonorrhoeae) 		no annotation 5 ILE A 101
LEU A  57
ALA A 108
ILE A   6
ILE A   7
 None
 0.93A 1epbB-5u1bA:
undetectable		 1epbB-5u1bA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 5 VAL A 382
LEU A 384
VAL A 188
ALA A 174
ILE A 224
 None
 0.95A 1epbB-5uc5A:
undetectable		 1epbB-5uc5A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE

(Hypericum
androsaemum) 		no annotation 5 VAL A 386
LEU A 388
VAL A 191
ALA A 177
ILE A 227
 None
 0.92A 1epbB-5ucoA:
undetectable		 1epbB-5ucoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A 255
VAL A 273
ALA A 330
ILE A 328
ILE A 326
 None
 0.95A 1epbB-5utuA:
undetectable		 1epbB-5utuA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 VAL 7 410
VAL 7 437
ALA 7 645
ILE 7 642
ILE 7 476
 None
 0.96A 1epbB-5v8f7:
undetectable		 1epbB-5v8f7:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x47 3-DEHYDROQUINATE
DEHYDRATASE

(Acinetobacter
baumannii) 		PF01220
(DHquinase_II) 		6 ILE A  32
ARG A  61
VAL A 101
ALA A 137
ILE A  74
ILE A  73
 None
 1.41A 1epbB-5x47A:
undetectable		 1epbB-5x47A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 5 ILE A 147
LYS A 118
VAL A  30
ALA A  24
ILE A 114
 None
 1.04A 1epbB-6bz0A:
undetectable		 1epbB-6bz0A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo2 TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB

(Salmonella
enterica) 		no annotation 5 ILE A  19
VAL A   6
VAL A 107
ALA A 119
ILE A 103
 None
 0.99A 1epbB-6eo2A:
undetectable		 1epbB-6eo2A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-) 		no annotation 5 VAL A  46
LEU A  40
ALA A 331
ILE A  60
ILE A  63
 None
 0.91A 1epbB-6gu8A:
1.8		 1epbB-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao3 VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		4 PHE A 138
LEU A   9
PHE A  32
VAL A 176
 None
 0.87A 1epbB-1ao3A:
0.0		 1epbB-1ao3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)

(Bos taurus) 		PF00246
(Peptidase_M14) 		4 LEU A 107
PHE A  86
VAL A  33
TYR A   9
 None
 0.78A 1epbB-1arlA:
0.0		 1epbB-1arlA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 ALA A 551
PHE A 539
VAL A 541
VAL A 568
 None
 0.48A 1epbB-1d0nA:
0.0		 1epbB-1d0nA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		4 LEU A 324
ALA A 148
VAL A 192
TYR A 130
 None
 0.62A 1epbB-1e1kA:
0.0		 1epbB-1e1kA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdi PHOSPHOGLYCERATE
KINASE

(Sus scrofa) 		PF00162
(PGK) 		4 LEU A   6
ALA A 184
VAL A 161
VAL A 159
 None
 0.85A 1epbB-1hdiA:
0.0		 1epbB-1hdiA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		4 LEU B 234
ALA B 239
PHE B 247
VAL B 249
 None
 0.55A 1epbB-1htrB:
0.0		 1epbB-1htrB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j4a D-LACTATE
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 293
ALA A 258
VAL A 232
VAL A 230
 None
 0.87A 1epbB-1j4aA:
0.0		 1epbB-1j4aA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv4 MAJOR URINARY
PROTEIN 2

(Mus musculus) 		PF00061
(Lipocalin) 		4 LEU A  52
ALA A  71
VAL A  82
TYR A 120
 None
None
None
TZL  A 170 (-4.1A)
 0.60A 1epbB-1jv4A:
17.4		 1epbB-1jv4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6r HYPOTHETICAL PROTEIN
TA0175

(Thermoplasma
acidophilum) 		PF08282
(Hydrolase_3) 		4 PHE A 204
LEU A 170
ALA A   5
VAL A  38
 None
 0.82A 1epbB-1l6rA:
undetectable		 1epbB-1l6rA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		4 ALA A 551
PHE A 539
VAL A 541
VAL A 568
 None
 0.45A 1epbB-1nphA:
undetectable		 1epbB-1nphA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata) 		PF02932
(Neur_chan_memb) 		4 PHE B 293
ALA B 235
VAL B 238
VAL B 301
 None
 0.73A 1epbB-1oedB:
undetectable		 1epbB-1oedB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p90 HYPOTHETICAL PROTEIN

(Azotobacter
vinelandii) 		PF02579
(Nitro_FeMo-Co) 		4 LEU A 169
ALA A 109
PHE A 128
VAL A 130
 None
 0.73A 1epbB-1p90A:
undetectable		 1epbB-1p90A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd6 PROTEIN (OUTER
MEMBRANE
PHOSPHOLIPASE
(OMPLA))

(Escherichia
coli) 		PF02253
(PLA1) 		4 LEU C 133
ALA C 164
VAL C 171
VAL C 173
 None
 0.82A 1epbB-1qd6C:
3.3		 1epbB-1qd6C:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfj PROTEIN (FLAVIN
REDUCTASE)

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 192
ALA A 219
PHE A 213
TYR A 198
 None
 0.81A 1epbB-1qfjA:
undetectable		 1epbB-1qfjA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Nostoc sp. PCC
7120) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 LEU A 320
ALA A 319
VAL A 337
VAL A 276
 None
 0.84A 1epbB-1vquA:
undetectable		 1epbB-1vquA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 PHE A 118
ALA A 154
VAL A 159
TYR A  77
 None
 0.86A 1epbB-2afbA:
undetectable		 1epbB-2afbA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)

(Archaeoglobus
fulgidus) 		PF00590
(TP_methylase) 		4 PHE A 149
ALA A  80
VAL A  79
VAL A 120
 None
SAH  A 201 (-3.4A)
SAH  A 201 (-3.9A)
None
 0.87A 1epbB-2bb3A:
undetectable		 1epbB-2bb3A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7u ADENYLOSUCCINATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00709
(Adenylsucc_synt) 		4 LEU A 322
ALA A 281
VAL A 220
VAL A   6
 None
 0.57A 1epbB-2d7uA:
undetectable		 1epbB-2d7uA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		4 LEU A 167
ALA A 125
VAL A  10
VAL A  32
 None
 0.79A 1epbB-2detA:
undetectable		 1epbB-2detA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6) 		PF01593
(Amino_oxidase) 		4 MET A 354
LEU A  62
ALA B 401
VAL C 640
 None
 0.78A 1epbB-2e1mA:
undetectable		 1epbB-2e1mA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhx SPM-1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 ALA B  45
PHE B  53
VAL B  55
VAL B  73
 None
 0.64A 1epbB-2fhxB:
undetectable		 1epbB-2fhxB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 LEU A 223
ALA A 220
PHE A 211
TYR A 402
 None
 0.87A 1epbB-2gmhA:
1.7		 1epbB-2gmhA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG

(Escherichia
coli) 		PF13098
(Thioredoxin_2) 		4 LEU A 195
ALA A 197
PHE A 104
TYR A 205
 None
 0.77A 1epbB-2h0iA:
undetectable		 1epbB-2h0iA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5u MREC PROTEIN

(Listeria
monocytogenes) 		PF04085
(MreC) 		4 PHE A 194
LEU A 209
ALA A 256
VAL A 245
 None
 0.76A 1epbB-2j5uA:
undetectable		 1epbB-2j5uA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkh PUTATIVE HEAVY METAL
TRANSPORTER

(Arabidopsis
thaliana) 		no annotation 4 ALA A  82
PHE A  21
VAL A  23
VAL A  57
 None
 0.76A 1epbB-2kkhA:
undetectable		 1epbB-2kkhA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00590
(TP_methylase) 		4 LEU A  34
PHE A 106
VAL A 108
VAL A   6
 None
 0.67A 1epbB-2npnA:
undetectable		 1epbB-2npnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqt HYPOTHETICAL PROTEIN
SPY0176

(Streptococcus
pyogenes) 		PF00359
(PTS_EIIA_2) 		4 LEU A 100
ALA A  29
VAL A  30
TYR A  57
 None
 0.83A 1epbB-2oqtA:
undetectable		 1epbB-2oqtA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		4 LEU A   6
ALA A 184
VAL A 161
VAL A 159
 None
 0.70A 1epbB-2paaA:
undetectable		 1epbB-2paaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfy PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		4 LEU A 137
ALA A 158
PHE A 142
VAL A 159
 None
 0.81A 1epbB-2pfyA:
undetectable		 1epbB-2pfyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pim PHENYLACETIC ACID
DEGRADATION-RELATED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF13622
(4HBT_3) 		4 LEU A  87
ALA A 132
VAL A 116
TYR A  42
 None
 0.88A 1epbB-2pimA:
undetectable		 1epbB-2pimA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 LEU A 454
ALA A 449
VAL A 445
VAL A 392
 None
 0.85A 1epbB-2x2iA:
undetectable		 1epbB-2x2iA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6k REPLICATION PROTEIN
A 32 KDA SUBUNIT

(Homo sapiens) 		PF08784
(RPA_C) 		4 PHE A 135
MET A 102
ALA A  57
PHE A  64
 None
 0.79A 1epbB-2z6kA:
undetectable		 1epbB-2z6kA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		4 LEU A 132
ALA A 239
PHE A 214
VAL A 216
 None
 0.81A 1epbB-3d2lA:
undetectable		 1epbB-3d2lA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU B 210
VAL B 181
VAL B 179
TYR B 301
 None
 0.80A 1epbB-3dm9B:
undetectable		 1epbB-3dm9B:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 146
ALA A 161
VAL A 168
VAL A 219
 None
 0.89A 1epbB-3dtcA:
undetectable		 1epbB-3dtcA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		4 ALA A 267
PHE A 112
VAL A 110
VAL A 250
 None
 0.85A 1epbB-3ez6A:
undetectable		 1epbB-3ez6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gle PILIN

(Streptococcus
pyogenes) 		PF12892
(FctA) 		4 PHE A 194
ALA A 227
VAL A 210
VAL A 245
 PHE  A 194 ( 1.3A)
ALA  A 227 ( 0.0A)
VAL  A 210 ( 0.6A)
VAL  A 245 ( 0.5A)
 0.63A 1epbB-3gleA:
undetectable		 1epbB-3gleA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		4 LEU A  86
PHE A  69
VAL A  67
VAL A  18
 None
 0.78A 1epbB-3go7A:
undetectable		 1epbB-3go7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		4 LEU A 194
ALA A 249
PHE A 231
VAL A 233
 None
 0.78A 1epbB-3h2bA:
undetectable		 1epbB-3h2bA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itd 17BETA-HYDROXYSTEROI
D DEHYDROGENASE

(Curvularia
lunata) 		PF13561
(adh_short_C2) 		4 PHE A 132
LEU A 150
ALA A 194
VAL A 262
 None
 0.58A 1epbB-3itdA:
undetectable		 1epbB-3itdA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k85 D-GLYCERO-D-MANNO-HE
PTOSE 1-PHOSPHATE
KINASE

(Bacteroides
thetaiotaomicron) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ALA A 288
PHE A 304
VAL A 306
VAL A 199
 None
 0.54A 1epbB-3k85A:
undetectable		 1epbB-3k85A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		4 LEU A 223
PHE A 188
VAL A 190
VAL A 281
 None
 0.76A 1epbB-3lfvA:
undetectable		 1epbB-3lfvA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxl NITROSOSYNTHASE

(Micromonospora
sp. ATCC 39149) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 133
PHE A 170
VAL A 172
VAL A 190
 None
 0.85A 1epbB-3mxlA:
undetectable		 1epbB-3mxlA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		4 LEU A 192
ALA A 214
VAL A 118
VAL A 146
 None
 0.63A 1epbB-3nk7A:
undetectable		 1epbB-3nk7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 LEU A 212
ALA A 252
PHE A 254
VAL A 241
 None
 0.86A 1epbB-3op1A:
undetectable		 1epbB-3op1A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqp PUTATIVE
ISOCHORISMATASE

(Paraburkholderia
xenovorans) 		PF00857
(Isochorismatase) 		4 ALA A 173
PHE A 138
VAL A 136
VAL A 113
 None
 0.84A 1epbB-3oqpA:
undetectable		 1epbB-3oqpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqp PUTATIVE
ISOCHORISMATASE

(Paraburkholderia
xenovorans) 		PF00857
(Isochorismatase) 		4 LEU A 168
ALA A 173
PHE A 138
VAL A 113
 None
 0.88A 1epbB-3oqpA:
undetectable		 1epbB-3oqpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfq PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
MOAB2

(Mycobacterium
marinum) 		PF00994
(MoCF_biosynth) 		4 LEU A  87
ALA A  28
PHE A  58
VAL A  60
 None
 0.73A 1epbB-3rfqA:
undetectable		 1epbB-3rfqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t02 PHOSPHONOACETATE
HYDROLASE

(Sinorhizobium
meliloti) 		PF01663
(Phosphodiest) 		5 PHE A 409
LEU A 402
ALA A  60
PHE A 387
VAL A 385
 None
 1.39A 1epbB-3t02A:
undetectable		 1epbB-3t02A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA

(Pyrococcus
furiosus) 		PF09376
(NurA) 		4 LEU A  78
ALA A  71
VAL A  50
TYR A 173
 None
 0.70A 1epbB-3talA:
undetectable		 1epbB-3talA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ALA A1592
PHE A1577
VAL A1579
VAL A1669
 None
 0.57A 1epbB-3va7A:
undetectable		 1epbB-3va7A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwh (R)-AMINE
TRANSAMINASE

(Arthrobacter
sp. KNK168) 		PF01063
(Aminotran_4) 		4 LEU A  80
ALA A  77
VAL A  72
VAL A 123
 None
 0.87A 1epbB-3wwhA:
undetectable		 1epbB-3wwhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp2 EPITHELIAL ADHESIN 9

([Candida]
glabrata) 		PF10528
(GLEYA) 		4 PHE A 267
LEU A 238
ALA A 226
PHE A 201
 None
 0.62A 1epbB-4cp2A:
undetectable		 1epbB-4cp2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn2 NITROREDUCTASE

(Geobacter
metallireducens) 		PF00881
(Nitroreductase) 		4 PHE A 136
LEU A  83
ALA A  82
VAL A 131
 None
 0.89A 1epbB-4dn2A:
undetectable		 1epbB-4dn2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 511
ALA A 526
VAL A 540
VAL A 587
 None
 0.88A 1epbB-4f0iA:
undetectable		 1epbB-4f0iA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE

(Mycobacterium
sp. JLS) 		PF04471
(Mrr_cat) 		4 LEU A 156
ALA A 182
VAL A 210
VAL A 112
 None
 0.57A 1epbB-4f0qA:
undetectable		 1epbB-4f0qA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 463
PHE A 168
VAL A 164
VAL A 212
 None
 0.79A 1epbB-4fdhA:
undetectable		 1epbB-4fdhA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyk UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		4 LEU A 193
ALA A 136
PHE A 138
VAL A 127
 None
 0.80A 1epbB-4iykA:
undetectable		 1epbB-4iykA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2o UDP-N-ACETYLGLUCOSAM
INE
4,6-DEHYDRATASE/5-EP
IMERASE

(Acinetobacter
baumannii) 		PF02719
(Polysacc_synt_2)
PF08485
(Polysacc_syn_2C) 		4 ALA A 273
PHE A 280
VAL A 282
VAL A 223
 None
 0.67A 1epbB-4j2oA:
undetectable		 1epbB-4j2oA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Paenarthrobacter
aurescens) 		PF00378
(ECH_1) 		4 LEU A 186
ALA A 183
PHE A 178
TYR A 151
 None
 0.81A 1epbB-4mouA:
undetectable		 1epbB-4mouA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3o PUTATIVE
D-GLYCERO-D-MANNO-HE
PTOSE 7-PHOSPHATE
KINASE

(Campylobacter
jejuni) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ALA A 287
PHE A 303
VAL A 305
VAL A 200
 None
 0.61A 1epbB-4n3oA:
undetectable		 1epbB-4n3oA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf) 		4 LEU A  51
ALA A   4
PHE A  34
VAL A  36
 None
 0.81A 1epbB-4o6mA:
undetectable		 1epbB-4o6mA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdv M7GPPPX
DIPHOSPHATASE

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		4 LEU A 202
ALA A 220
VAL A 278
VAL A 265
 None
 0.87A 1epbB-4qdvA:
undetectable		 1epbB-4qdvA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 4 PHE H 443
LEU H 500
ALA H 296
VAL H 429
 None
 0.68A 1epbB-4qfkH:
undetectable		 1epbB-4qfkH:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qu2 JMJC
DOMAIN-CONTAINING
PROTEIN 7

(Mus musculus) 		PF13621
(Cupin_8) 		4 LEU A 168
VAL A 288
VAL A 189
TYR A  71
 None
 0.83A 1epbB-4qu2A:
undetectable		 1epbB-4qu2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvj VP1

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 PHE A 493
ALA A 502
PHE A 227
VAL A 225
 None
 0.81A 1epbB-4qvjA:
undetectable		 1epbB-4qvjA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rz2 SITE-DETERMINING
PROTEIN

(Geobacillus
thermodenitrificans) 		PF10609
(ParA) 		4 LEU A 223
PHE A 159
VAL A 161
VAL A  27
 None
 0.83A 1epbB-4rz2A:
undetectable		 1epbB-4rz2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tjv VACUOLAR-SORTING
RECEPTOR 1

(Arabidopsis
thaliana) 		PF02225
(PA) 		4 LEU A 150
ALA A  43
PHE A  21
VAL A  23
 None
 0.87A 1epbB-4tjvA:
undetectable		 1epbB-4tjvA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		4 ALA A 224
PHE A 192
VAL A 194
VAL A 261
 None
 0.46A 1epbB-4u48A:
undetectable		 1epbB-4u48A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utg SUGAR KINASE

(Burkholderia
pseudomallei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ALA A 292
PHE A 308
VAL A 310
VAL A 203
 None
 0.63A 1epbB-4utgA:
undetectable		 1epbB-4utgA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8d CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43) 		4 LEU A 194
ALA A 177
VAL A 171
VAL A 111
 None
 0.79A 1epbB-5a8dA:
undetectable		 1epbB-5a8dA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		4 LEU A 182
ALA A 233
VAL A 308
VAL A 350
 None
 0.88A 1epbB-5axhA:
undetectable		 1epbB-5axhA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU A 584
ALA A 581
VAL A 571
VAL A 549
 None
 0.87A 1epbB-5c70A:
undetectable		 1epbB-5c70A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE

(Archaeoglobus
fulgidus;
Renibacterium
salmoninarum) 		PF01066
(CDP-OH_P_transf) 		4 LEU A -80
ALA A-127
PHE A -97
VAL A -95
 None
 0.83A 1epbB-5d91A:
undetectable		 1epbB-5d91A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du2 ESPG2
GLYCOSYLTRANSFERASE

(Actinomadura
verrucosospora) 		PF00201
(UDPGT) 		4 LEU A 294
ALA A 297
VAL A 232
VAL A 263
 None
 0.78A 1epbB-5du2A:
undetectable		 1epbB-5du2A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF01855
(POR_N)
PF17147
(PFOR_II) 		4 PHE A 298
ALA A 293
PHE A 267
VAL A 292
 None
 0.83A 1epbB-5exeA:
undetectable		 1epbB-5exeA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd CASEIN KINASE I
ISOFORM ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU C  19
ALA C  34
VAL C  43
VAL C  89
 None
 0.84A 1epbB-5fqdC:
undetectable		 1epbB-5fqdC:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 LEU A 116
ALA A 115
VAL A  69
VAL A  95
 None
 0.84A 1epbB-5fsrA:
undetectable		 1epbB-5fsrA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gha SULFUR CARRIER TTUB

(Thermus
thermophilus) 		no annotation 4 LEU E  44
ALA E  37
VAL E  58
VAL E   3
 None
EDO  E 101 (-3.3A)
None
None
 0.71A 1epbB-5ghaE:
undetectable		 1epbB-5ghaE:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 LEU A   6
ALA A  15
VAL A  23
VAL A  58
 None
 0.86A 1epbB-5ginA:
undetectable		 1epbB-5ginA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h55 MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Kluyveromyces
lactis) 		no annotation 4 PHE A 217
LEU A  40
ALA A 106
VAL A 122
 None
 0.83A 1epbB-5h55A:
undetectable		 1epbB-5h55A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 LEU A1991
ALA A1934
VAL A1919
TYR A1874
 None
 0.69A 1epbB-5i6gA:
2.5		 1epbB-5i6gA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 LEU A1991
ALA A1934
VAL A1919
TYR A1874
 None
 0.75A 1epbB-5i6hA:
undetectable		 1epbB-5i6hA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 LEU A1991
ALA A1934
VAL A1919
TYR A1874
 None
 0.72A 1epbB-5i6iA:
2.4		 1epbB-5i6iA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ALA A1592
PHE A1577
VAL A1579
VAL A1669
 None
 0.55A 1epbB-5i8iA:
undetectable		 1epbB-5i8iA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it9 RIBOSOMAL PROTEIN
ES12

(Kluyveromyces
lactis) 		PF01248
(Ribosomal_L7Ae) 		4 LEU M  79
ALA M  53
VAL M 113
VAL M 111
 None
 0.83A 1epbB-5it9M:
undetectable		 1epbB-5it9M:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kpe DE NOVO BETA SHEET
DESIGN PROTEIN OR664

(synthetic
construct) 		no annotation 4 LEU A  35
PHE A  94
VAL A  96
VAL A  71
 None
 0.76A 1epbB-5kpeA:
undetectable		 1epbB-5kpeA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ALA A 522
PHE A 492
VAL A 494
VAL A 489
 None
 0.84A 1epbB-5kshA:
undetectable		 1epbB-5kshA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7

(Homo sapiens) 		no annotation 4 LEU A 168
VAL A 288
VAL A 189
TYR A  71
 None
 0.76A 1epbB-5nfnA:
undetectable		 1epbB-5nfnA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2

(Homo sapiens) 		no annotation 4 LEU A 464
ALA A 479
VAL A 488
VAL A 543
 None
 0.82A 1epbB-5o0yA:
undetectable		 1epbB-5o0yA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 4 PHE A 235
ALA A 133
VAL A 104
TYR A 251
 None
PLM  A 401 (-2.8A)
PLM  A 401 ( 4.7A)
None
 0.81A 1epbB-5oceA:
undetectable		 1epbB-5oceA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE

(Xenopus
tropicalis) 		no annotation 4 LEU A 256
ALA A 282
VAL A 297
VAL A 299
 None
 0.81A 1epbB-5oj7A:
undetectable		 1epbB-5oj7A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t13 CYANURIC ACID
AMIDOHYDROLASE

(Enterobacter
cloacae) 		PF09663
(Amido_AtzD_TrzD) 		4 PHE A 159
LEU A 114
ALA A   3
VAL A  98
 None
 0.73A 1epbB-5t13A:
undetectable		 1epbB-5t13A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE

(Zika virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		4 ALA A  13
VAL A  87
VAL A 103
TYR A 195
 None
 0.83A 1epbB-5t1vA:
undetectable		 1epbB-5t1vA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t77 PUTATIVE LIPID II
FLIPPASE MURJ

(Thermosipho
africanus) 		PF03023
(MVIN) 		4 LEU A 377
ALA A 393
PHE A 381
VAL A 390
 None
None
OLC  A 531 ( 4.4A)
None
 0.88A 1epbB-5t77A:
undetectable		 1epbB-5t77A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuj ANCESTRAL PROTEIN
CDT-ANC1

(unidentified) 		no annotation 4 PHE C 151
ALA C 177
VAL C 115
VAL C 200
 None
 0.75A 1epbB-5tujC:
undetectable		 1epbB-5tujC:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A  13
ALA A  28
VAL A  37
VAL A  91
 None
 0.84A 1epbB-5u94A:
undetectable		 1epbB-5u94A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vol PUTATIVE ESTERASE

(Bacteroides
intestinalis) 		PF00756
(Esterase) 		4 PHE A  44
LEU A  62
ALA A 149
VAL A 281
 None
 0.88A 1epbB-5volA:
undetectable		 1epbB-5volA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 4 LEU A  21
ALA A  35
VAL A  44
VAL A  94
 None
 0.89A 1epbB-5w5jA:
undetectable		 1epbB-5w5jA:
18.60