SIMILAR PATTERNS OF AMINO ACIDS FOR 1EPB_A_9CRA165_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a1s ORNITHINE
CARBAMOYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 213
ALA A 184
VAL A 160
VAL A 158
 None
 0.77A 1epbA-1a1sA:
undetectable		 1epbA-1a1sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1afi MERP

(Shigella
flexneri) 		PF00403
(HMA) 		4 LEU A   7
ALA A  43
VAL A  36
VAL A  34
 None
 0.79A 1epbA-1afiA:
undetectable		 1epbA-1afiA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao3 VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		4 PHE A 138
LEU A   9
PHE A  32
VAL A 176
 None
 0.90A 1epbA-1ao3A:
0.1		 1epbA-1ao3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)

(Bos taurus) 		PF00246
(Peptidase_M14) 		4 LEU A 107
PHE A  86
VAL A  33
TYR A   9
 None
 0.66A 1epbA-1arlA:
undetectable		 1epbA-1arlA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2p PROTEIN (LECTIN)

(Hyacinthoides
hispanica) 		PF01453
(B_lectin) 		4 LEU A  17
ALA A  65
VAL A  75
TYR A  45
 None
 0.73A 1epbA-1b2pA:
undetectable		 1epbA-1b2pA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)

(Thermotoga
maritima) 		PF01584
(CheW)
PF02518
(HATPase_c)
PF02895
(H-kinase_dim) 		4 LEU A 567
ALA A 612
VAL A 625
VAL A 592
 None
 0.64A 1epbA-1b3qA:
0.0		 1epbA-1b3qA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 ALA A 551
PHE A 539
VAL A 541
VAL A 568
 None
 0.56A 1epbA-1d0nA:
1.2		 1epbA-1d0nA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		4 LEU A 324
ALA A 148
VAL A 192
TYR A 130
 None
 0.58A 1epbA-1e1kA:
undetectable		 1epbA-1e1kA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		4 LEU A  73
ALA A  58
VAL A  96
TYR A  18
 None
 0.68A 1epbA-1hdfA:
undetectable		 1epbA-1hdfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdi PHOSPHOGLYCERATE
KINASE

(Sus scrofa) 		PF00162
(PGK) 		4 LEU A   6
ALA A 184
VAL A 161
VAL A 159
 None
 0.81A 1epbA-1hdiA:
undetectable		 1epbA-1hdiA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		4 LEU B 234
ALA B 239
PHE B 247
VAL B 249
 None
 0.57A 1epbA-1htrB:
undetectable		 1epbA-1htrB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iba GLUCOSE PERMEASE

(Escherichia
coli) 		PF00367
(PTS_EIIB) 		5 LEU A  39
ALA A  71
PHE A  73
VAL A  62
TYR A  87
 None
 1.32A 1epbA-1ibaA:
undetectable		 1epbA-1ibaA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j4a D-LACTATE
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 293
ALA A 258
VAL A 232
VAL A 230
 None
 0.85A 1epbA-1j4aA:
undetectable		 1epbA-1j4aA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01135
(PCMT) 		4 LEU A 108
ALA A  42
PHE A  43
TYR A  49
 None
 0.83A 1epbA-1jg3A:
undetectable		 1epbA-1jg3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn1 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Haemophilus
influenzae) 		PF02542
(YgbB) 		4 PHE A  82
LEU A  45
VAL A 130
VAL A 128
 None
 0.88A 1epbA-1jn1A:
undetectable		 1epbA-1jn1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv4 MAJOR URINARY
PROTEIN 2

(Mus musculus) 		PF00061
(Lipocalin) 		4 LEU A  52
ALA A  71
VAL A  82
TYR A 120
 None
None
None
TZL  A 170 (-4.1A)
 0.57A 1epbA-1jv4A:
17.0		 1epbA-1jv4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6r HYPOTHETICAL PROTEIN
TA0175

(Thermoplasma
acidophilum) 		PF08282
(Hydrolase_3) 		4 PHE A 204
LEU A 170
ALA A   5
VAL A  38
 None
 0.87A 1epbA-1l6rA:
undetectable		 1epbA-1l6rA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 LEU A 317
ALA A 150
VAL A 194
TYR A 132
 None
 0.73A 1epbA-1lqtA:
undetectable		 1epbA-1lqtA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7j PHENYLETHANOLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		4 LEU A 262
VAL A 269
VAL A 272
TYR A  85
 None
None
None
SAH  A2002 (-4.6A)
 0.82A 1epbA-1n7jA:
undetectable		 1epbA-1n7jA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		4 ALA A 551
PHE A 539
VAL A 541
VAL A 568
 None
 0.47A 1epbA-1nphA:
undetectable		 1epbA-1nphA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata) 		PF02932
(Neur_chan_memb) 		4 PHE B 293
ALA B 235
VAL B 238
VAL B 301
 None
 0.73A 1epbA-1oedB:
undetectable		 1epbA-1oedB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p90 HYPOTHETICAL PROTEIN

(Azotobacter
vinelandii) 		PF02579
(Nitro_FeMo-Co) 		4 LEU A 169
ALA A 109
PHE A 128
VAL A 130
 None
 0.87A 1epbA-1p90A:
undetectable		 1epbA-1p90A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q40 MRNA TRANSPORT
REGULATOR MTR2

(Candida
albicans) 		PF10429
(Mtr2) 		4 LEU A  85
ALA A 105
VAL A 146
VAL A 148
 None
 0.87A 1epbA-1q40A:
undetectable		 1epbA-1q40A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd6 PROTEIN (OUTER
MEMBRANE
PHOSPHOLIPASE
(OMPLA))

(Escherichia
coli) 		PF02253
(PLA1) 		4 LEU C 133
ALA C 164
VAL C 171
VAL C 173
 None
 0.88A 1epbA-1qd6C:
2.4		 1epbA-1qd6C:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfj PROTEIN (FLAVIN
REDUCTASE)

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 192
ALA A 219
PHE A 213
TYR A 198
 None
 0.86A 1epbA-1qfjA:
undetectable		 1epbA-1qfjA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos) 		4 ALA B 146
PHE B 157
VAL B 159
VAL B 196
 None
 0.89A 1epbA-1sr4B:
undetectable		 1epbA-1sr4B:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 191
ALA A 196
VAL A 178
VAL A 156
 None
 0.86A 1epbA-1tt7A:
undetectable		 1epbA-1tt7A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		4 PHE A 223
ALA A 268
VAL A 241
VAL A 203
 None
 0.90A 1epbA-1up2A:
undetectable		 1epbA-1up2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		4 LEU A 129
PHE A 151
VAL A 153
VAL A 186
 None
 0.90A 1epbA-1vcgA:
undetectable		 1epbA-1vcgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Nostoc sp. PCC
7120) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 LEU A 320
ALA A 319
VAL A 337
VAL A 276
 None
 0.90A 1epbA-1vquA:
undetectable		 1epbA-1vquA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wo8 METHYLGLYOXAL
SYNTHASE

(Thermus
thermophilus) 		PF02142
(MGS) 		4 LEU A  33
ALA A   5
VAL A  76
VAL A  68
 None
 0.90A 1epbA-1wo8A:
undetectable		 1epbA-1wo8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs3 HYPOTHETICAL PROTEIN
XC975

(Xanthomonas
euvesicatoria) 		PF01722
(BolA) 		4 LEU A  81
ALA A  45
VAL A  35
VAL A  33
 None
 0.79A 1epbA-1xs3A:
undetectable		 1epbA-1xs3A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		4 PHE A 173
PHE A  66
VAL A  68
VAL A 185
 None
 0.85A 1epbA-1ytmA:
undetectable		 1epbA-1ytmA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuo HYPOTHETICAL PROTEIN
LOC92912

(Homo sapiens) 		PF00179
(UQ_con) 		4 PHE A 272
LEU A 209
ALA A 205
PHE A 278
 None
 0.84A 1epbA-1zuoA:
undetectable		 1epbA-1zuoA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 PHE A 118
ALA A 154
VAL A 159
TYR A  77
 None
 0.90A 1epbA-2afbA:
undetectable		 1epbA-2afbA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 ALA A 109
PHE A 111
VAL A  57
VAL A  55
 None
 0.85A 1epbA-2b39A:
undetectable		 1epbA-2b39A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cda GLUCOSE
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		5 PHE A 123
ALA A 149
PHE A 313
VAL A 317
VAL A 136
 None
 1.27A 1epbA-2cdaA:
undetectable		 1epbA-2cdaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A  68
ALA A  73
VAL A  28
VAL A   5
 None
 0.85A 1epbA-2cduA:
undetectable		 1epbA-2cduA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7u ADENYLOSUCCINATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00709
(Adenylsucc_synt) 		4 LEU A  69
ALA A  33
VAL A 175
VAL A 173
 None
 0.65A 1epbA-2d7uA:
undetectable		 1epbA-2d7uA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7u ADENYLOSUCCINATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00709
(Adenylsucc_synt) 		4 LEU A 322
ALA A 281
VAL A 220
VAL A   6
 None
 0.65A 1epbA-2d7uA:
undetectable		 1epbA-2d7uA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyx V-CRK SARCOMA VIRUS
CT10 ONCOGENE
HOMOLOG ISOFORM A

(Homo sapiens) 		PF07653
(SH3_2) 		4 LEU A 293
ALA A 240
VAL A 264
VAL A 266
 None
 0.76A 1epbA-2eyxA:
undetectable		 1epbA-2eyxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhx SPM-1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 ALA B  45
PHE B  53
VAL B  55
VAL B  73
 None
 0.75A 1epbA-2fhxB:
undetectable		 1epbA-2fhxB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 218
ALA A 226
PHE A 228
VAL A 149
 None
 0.90A 1epbA-2glxA:
undetectable		 1epbA-2glxA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG

(Escherichia
coli) 		PF13098
(Thioredoxin_2) 		4 LEU A 195
ALA A 197
PHE A 104
TYR A 205
 None
 0.78A 1epbA-2h0iA:
undetectable		 1epbA-2h0iA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350

(Human
gammaherpesvirus
4) 		PF05109
(Herpes_BLLF1) 		4 LEU A  63
ALA A  48
VAL A 130
VAL A 128
 None
 0.63A 1epbA-2h6oA:
undetectable		 1epbA-2h6oA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 LEU A  55
ALA A  70
VAL A  79
VAL A 128
 None
 0.86A 1epbA-2hakA:
undetectable		 1epbA-2hakA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 LEU A 296
ALA A 299
VAL A 233
VAL A 265
 None
 0.87A 1epbA-2iyfA:
undetectable		 1epbA-2iyfA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5u MREC PROTEIN

(Listeria
monocytogenes) 		PF04085
(MreC) 		4 PHE A 194
LEU A 209
ALA A 256
VAL A 245
 None
 0.83A 1epbA-2j5uA:
undetectable		 1epbA-2j5uA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkh PUTATIVE HEAVY METAL
TRANSPORTER

(Arabidopsis
thaliana) 		no annotation 4 ALA A  82
PHE A  21
VAL A  23
VAL A  57
 None
 0.83A 1epbA-2kkhA:
undetectable		 1epbA-2kkhA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9c DARCIN

(Mus musculus) 		PF00061
(Lipocalin) 		4 LEU A  71
ALA A  90
VAL A 101
TYR A 139
 None
 0.68A 1epbA-2l9cA:
13.9		 1epbA-2l9cA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkn AH
RECEPTOR-INTERACTING
PROTEIN

(Homo sapiens) 		PF00254
(FKBP_C) 		5 PHE A 150
LEU A  62
ALA A  34
PHE A  36
VAL A 157
 None
 1.46A 1epbA-2lknA:
undetectable		 1epbA-2lknA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqb COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		4 LEU A  11
ALA A  47
VAL A  40
VAL A  38
 None
 0.84A 1epbA-2lqbA:
undetectable		 1epbA-2lqbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m2b RNA-BINDING PROTEIN
10

(Homo sapiens) 		PF00076
(RRM_1) 		4 LEU A  28
ALA A  70
VAL A  57
VAL A  55
 None
 0.89A 1epbA-2m2bA:
undetectable		 1epbA-2m2bA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00590
(TP_methylase) 		4 LEU A  34
PHE A 106
VAL A 108
VAL A   6
 None
 0.72A 1epbA-2npnA:
undetectable		 1epbA-2npnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 786
ALA A 792
PHE A 758
VAL A 762
 None
 0.82A 1epbA-2ogvA:
undetectable		 1epbA-2ogvA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozu HISTONE
ACETYLTRANSFERASE
MYST3

(Homo sapiens) 		PF01853
(MOZ_SAS) 		4 ALA A 567
PHE A 579
VAL A 581
VAL A 617
 None
 0.85A 1epbA-2ozuA:
undetectable		 1epbA-2ozuA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		4 LEU A   6
ALA A 184
VAL A 161
VAL A 159
 None
 0.63A 1epbA-2paaA:
undetectable		 1epbA-2paaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfy PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		4 LEU A 137
ALA A 158
PHE A 142
VAL A 159
 None
 0.84A 1epbA-2pfyA:
undetectable		 1epbA-2pfyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pim PHENYLACETIC ACID
DEGRADATION-RELATED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF13622
(4HBT_3) 		4 LEU A  87
ALA A 132
VAL A 116
TYR A  42
 None
 0.76A 1epbA-2pimA:
2.9		 1epbA-2pimA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3l UNCHARACTERIZED
PROTEIN

(Shewanella
loihica) 		PF11964
(SpoIIAA-like) 		4 LEU A  21
ALA A  55
VAL A  87
TYR A  34
 None
None
None
MPD  A 129 (-4.3A)
 0.78A 1epbA-2q3lA:
undetectable		 1epbA-2q3lA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r73 TRICHOSURIN

(Trichosurus
vulpecula) 		PF00061
(Lipocalin) 		4 LEU A  61
ALA A  80
PHE A  89
VAL A  99
 None
 0.85A 1epbA-2r73A:
15.0		 1epbA-2r73A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rog HEAVY METAL BINDING
PROTEIN

(Thermus
thermophilus) 		PF00403
(HMA) 		4 LEU A   4
ALA A  40
VAL A  33
VAL A  18
 None
 0.90A 1epbA-2rogA:
undetectable		 1epbA-2rogA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A  85
ALA A  65
PHE A  37
VAL A  39
 None
None
None
IN5  A1394 (-4.6A)
 0.85A 1epbA-2vd9A:
undetectable		 1epbA-2vd9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Bacillus
subtilis) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		4 LEU A  90
ALA A 116
VAL A 133
VAL A 128
 None
 0.74A 1epbA-2vt2A:
undetectable		 1epbA-2vt2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfb PUTATIVE
UNCHARACTERIZED
PROTEIN ORP

(Desulfovibrio
gigas) 		PF02579
(Nitro_FeMo-Co) 		4 ALA A   8
PHE A  30
VAL A  32
VAL A  43
 None
 0.72A 1epbA-2wfbA:
undetectable		 1epbA-2wfbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 PHE A  42
PHE A  93
VAL A  91
VAL A  77
 None
 0.88A 1epbA-2x2iA:
1.5		 1epbA-2x2iA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		5 PHE A 368
LEU A 454
ALA A 449
VAL A 445
VAL A 392
 None
 1.44A 1epbA-2x2iA:
1.5		 1epbA-2x2iA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmr PROTEIN NDRG2

(Homo sapiens) 		PF03096
(Ndr) 		5 LEU A  52
ALA A  50
VAL A  82
VAL A  40
TYR A 120
 None
 1.48A 1epbA-2xmrA:
undetectable		 1epbA-2xmrA:
18.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xst LIPOCALIN 15

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  71
PHE A  99
VAL A 101
VAL A 109
 None
 0.64A 1epbA-2xstA:
18.1		 1epbA-2xstA:
31.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y93 CIS-2,3-DIHYDROBIPHE
NYL-2,3-DIOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF00106
(adh_short) 		4 LEU A   9
ALA A  33
VAL A  54
VAL A  56
 None
 0.75A 1epbA-2y93A:
undetectable		 1epbA-2y93A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvt HYPOTHETICAL PROTEIN
AQ_1956

(Aquifex
aeolicus) 		PF14582
(Metallophos_3) 		4 PHE A 134
PHE A  93
VAL A  95
VAL A  37
 None
 0.90A 1epbA-2yvtA:
undetectable		 1epbA-2yvtA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 PHE A 296
LEU A 326
VAL A 265
VAL A 262
 None
 0.86A 1epbA-2yxxA:
undetectable		 1epbA-2yxxA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 299
ALA A 324
PHE A 321
VAL A 317
 None
 0.90A 1epbA-3a9vA:
undetectable		 1epbA-3a9vA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai2 NADPH-SORBOSE
REDUCTASE

(Gluconobacter
frateurii) 		PF13561
(adh_short_C2) 		4 LEU A 127
ALA A  86
VAL A   9
VAL A  35
 None
 0.81A 1epbA-3ai2A:
undetectable		 1epbA-3ai2A:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 LEU A 140
ALA A 143
VAL A  64
TYR A 112
 None
GOL  A 146 ( 4.6A)
GOL  A 146 ( 4.8A)
GOL  A 145 (-4.4A)
 0.83A 1epbA-3b8lA:
undetectable		 1epbA-3b8lA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE

(Streptomyces
venezuelae) 		PF13649
(Methyltransf_25) 		4 LEU A  42
ALA A 101
VAL A 134
VAL A 136
 None
 0.69A 1epbA-3bxoA:
undetectable		 1epbA-3bxoA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0u UNCHARACTERIZED
PROTEIN YAEQ

(Escherichia
coli) 		PF07152
(YaeQ) 		4 LEU A 163
ALA A 154
VAL A  14
VAL A  12
 None
 0.81A 1epbA-3c0uA:
undetectable		 1epbA-3c0uA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		4 LEU A 132
ALA A 239
PHE A 214
VAL A 216
 None
 0.79A 1epbA-3d2lA:
undetectable		 1epbA-3d2lA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21

(Actinoplanes
teichomyceticus) 		PF02585
(PIG-L) 		4 LEU A 150
ALA A  12
VAL A  40
VAL A  38
 None
 0.61A 1epbA-3dfiA:
undetectable		 1epbA-3dfiA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl3 TELLURITE RESISTANCE
PROTEIN B

(Aliivibrio
fischeri) 		PF09313
(DUF1971) 		4 LEU A  86
ALA A  90
PHE A  92
VAL A  44
 None
 0.82A 1epbA-3dl3A:
undetectable		 1epbA-3dl3A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU B 210
VAL B 181
VAL B 179
TYR B 301
 None
 0.67A 1epbA-3dm9B:
undetectable		 1epbA-3dm9B:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evn OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
agalactiae) 		PF01408
(GFO_IDH_MocA) 		4 PHE A 111
LEU A  88
ALA A  87
VAL A  73
 None
 0.90A 1epbA-3evnA:
undetectable		 1epbA-3evnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		4 ALA A 267
PHE A 112
VAL A 110
VAL A 250
 None
 0.75A 1epbA-3ez6A:
undetectable		 1epbA-3ez6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1c PUTATIVE
2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
2

(Listeria
monocytogenes) 		PF01128
(IspD) 		4 LEU A 129
ALA A 128
VAL A 134
VAL A 107
 None
 0.90A 1epbA-3f1cA:
undetectable		 1epbA-3f1cA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE

(Salmonella
enterica) 		PF00215
(OMPdecase) 		4 LEU A  73
ALA A  78
VAL A  56
VAL A  31
 None
 0.90A 1epbA-3f4wA:
undetectable		 1epbA-3f4wA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 LEU A 477
ALA A 471
PHE A 469
VAL A 352
VAL A 354
 None
 1.18A 1epbA-3fahA:
undetectable		 1epbA-3fahA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU A 292
ALA A 291
PHE A 277
VAL A 279
 None
 0.90A 1epbA-3fr8A:
undetectable		 1epbA-3fr8A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gle PILIN

(Streptococcus
pyogenes) 		PF12892
(FctA) 		4 PHE A 194
ALA A 227
VAL A 210
VAL A 245
 PHE  A 194 ( 1.3A)
ALA  A 227 ( 0.0A)
VAL  A 210 ( 0.6A)
VAL  A 245 ( 0.5A)
 0.60A 1epbA-3gleA:
undetectable		 1epbA-3gleA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		4 LEU A  86
PHE A  69
VAL A  67
VAL A  18
 None
 0.71A 1epbA-3go7A:
undetectable		 1epbA-3go7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		4 ALA A  88
PHE A  68
VAL A  70
VAL A  61
 None
 0.79A 1epbA-3gs9A:
undetectable		 1epbA-3gs9A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		5 PHE A 197
LEU A 111
ALA A 110
VAL A 252
VAL A 244
 None
 1.35A 1epbA-3h14A:
undetectable		 1epbA-3h14A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		4 LEU A 194
ALA A 249
PHE A 231
VAL A 233
 None
 0.73A 1epbA-3h2bA:
undetectable		 1epbA-3h2bA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		4 ALA A 172
PHE A 144
VAL A 146
VAL A 120
 None
 0.87A 1epbA-3h7tA:
undetectable		 1epbA-3h7tA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 PHE A 903
ALA A 924
PHE A 659
VAL A 922
VAL A 913
 None
 1.35A 1epbA-3hmjA:
undetectable		 1epbA-3hmjA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		4 PHE B 311
ALA B 189
VAL B 205
VAL B 202
 None
 0.87A 1epbA-3hrdB:
undetectable		 1epbA-3hrdB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxl UNCHARACTERIZED
PROTEIN DSY3957

(Desulfitobacterium
hafniense) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 LEU A 405
ALA A 420
VAL A 433
VAL A 435
 None
 0.77A 1epbA-3hxlA:
undetectable		 1epbA-3hxlA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		5 PHE A 304
LEU A  47
ALA A 102
PHE A  89
VAL A 103
 None
 1.47A 1epbA-3i3lA:
undetectable		 1epbA-3i3lA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ia7 CALG4

(Micromonospora
echinospora) 		PF00201
(UDPGT) 		4 LEU A 294
ALA A 297
VAL A 232
VAL A 263
 None
 0.87A 1epbA-3ia7A:
undetectable		 1epbA-3ia7A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib7 ICC PROTEIN

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		4 LEU A 168
ALA A 205
VAL A 223
VAL A 221
 None
 0.89A 1epbA-3ib7A:
undetectable		 1epbA-3ib7A:
21.12