SIMILAR PATTERNS OF AMINO ACIDS FOR 1EPB_A_9CRA165_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 1.00A 1epbA-1d6hA:
undetectable		 1epbA-1d6hA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei6 PHOSPHONOACETATE
HYDROLASE

(Pseudomonas
fluorescens) 		PF01663
(Phosphodiest) 		5 PHE A 142
ILE A 160
VAL A 123
ALA A 121
ILE A  22
 None
 1.00A 1epbA-1ei6A:
undetectable		 1epbA-1ei6A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hh2 N UTILIZATION
SUBSTANCE PROTEIN A

(Thermotoga
maritima) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		5 TRP P 166
VAL P 142
ALA P 150
ILE P 152
ILE P 154
 None
 0.94A 1epbA-1hh2P:
undetectable		 1epbA-1hh2P:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 VAL A 406
LEU A 404
VAL A 496
ALA A 414
ILE A 398
 None
 1.04A 1epbA-1jedA:
undetectable		 1epbA-1jedA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji0 ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 PHE A 125
VAL A  85
VAL A 180
ILE A 181
ILE A  33
 None
 0.94A 1epbA-1ji0A:
undetectable		 1epbA-1ji0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3g CYTOCHROME C-553

(Sporosarcina
pasteurii) 		PF13442
(Cytochrome_CBB3) 		5 ILE A  33
MET A  71
VAL A  84
ALA A  76
ILE A  64
 None
HEC  A  93 (-2.4A)
HEC  A  93 (-4.2A)
HEC  A  93 ( 3.6A)
HEC  A  93 (-3.6A)
 0.96A 1epbA-1k3gA:
undetectable		 1epbA-1k3gA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A 500
VAL A 210
LEU A 443
ALA A 226
ILE A 474
 None
 0.91A 1epbA-1knrA:
undetectable		 1epbA-1knrA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktj ALLERGEN DER P 2

(Dermatophagoides
pteronyssinus) 		PF02221
(E1_DerP2_DerF2) 		6 ILE A  29
LEU A  37
VAL A  65
ALA A  56
ILE A  54
ILE A  52
 None
 1.24A 1epbA-1ktjA:
0.9		 1epbA-1ktjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktj ALLERGEN DER P 2

(Dermatophagoides
pteronyssinus) 		PF02221
(E1_DerP2_DerF2) 		5 LEU A  37
VAL A 110
ALA A  72
ILE A  52
ILE A  54
 None
 1.00A 1epbA-1ktjA:
0.9		 1epbA-1ktjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1

(Homo sapiens) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LYS A 249
VAL A 253
ALA A 329
ILE A 327
ILE A 325
 None
 0.77A 1epbA-1l1fA:
undetectable		 1epbA-1l1fA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 PHE A  12
ILE A 361
VAL A 335
ALA A 375
ILE A 311
ILE A 292
 None
 1.29A 1epbA-1mewA:
undetectable		 1epbA-1mewA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A1012
VAL A1033
ALA A1053
ILE A1056
ILE A1058
 None
 0.97A 1epbA-1ofeA:
undetectable		 1epbA-1ofeA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A  72
VAL A   5
LEU A  23
ALA A  79
ILE A  81
 None
 1.03A 1epbA-1p43A:
undetectable		 1epbA-1p43A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		5 ILE A  41
LEU A 105
VAL A  38
ALA A  47
ILE A  57
 None
 1.02A 1epbA-1pe9A:
undetectable		 1epbA-1pe9A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 ILE A  11
LEU A  87
VAL A 144
ALA A 243
ILE A 185
 None
 1.01A 1epbA-1spxA:
undetectable		 1epbA-1spxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 385
LEU A 373
VAL A 227
ILE A  21
ILE A  24
 None
 0.92A 1epbA-1u0uA:
undetectable		 1epbA-1u0uA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0x NITROPHORIN 4

(Rhodnius
prolixus) 		PF02087
(Nitrophorin) 		5 PHE A  12
TRP A  23
VAL A 109
ALA A 117
ILE A 119
 None
 0.90A 1epbA-1u0xA:
15.0		 1epbA-1u0xA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uit HUMAN DISCS LARGE 5
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A  49
VAL A  23
ALA A  97
ILE A  95
ILE A  93
 None
 0.91A 1epbA-1uitA:
undetectable		 1epbA-1uitA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v74 COLICIN D IMMUNITY
PROTEIN

(Escherichia
coli) 		PF09204
(Colicin_immun) 		5 PHE B  23
ILE B  27
VAL B  78
ILE B  81
LYS B  84
 None
 1.01A 1epbA-1v74B:
undetectable		 1epbA-1v74B:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE

(Sulfurisphaera
tokodaii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A  28
LYS A  97
VAL A  71
ALA A  89
ILE A  92
 None
 1.01A 1epbA-1wydA:
undetectable		 1epbA-1wydA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwv DER F II

(Dermatophagoides
farinae) 		PF02221
(E1_DerP2_DerF2) 		6 ILE A  29
LEU A  37
VAL A  65
ALA A  56
ILE A  54
ILE A  52
 None
PE3  A1001 (-4.5A)
PE3  A1001 ( 4.0A)
PE3  A1001 ( 4.1A)
PE3  A1001 (-4.8A)
PE3  A1001 ( 4.3A)
 1.09A 1epbA-1xwvA:
undetectable		 1epbA-1xwvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N

(Mus musculus) 		PF00079
(Serpin) 		5 PHE A  54
ILE A  78
VAL A 355
LEU A 205
ILE A  97
 None
 0.95A 1epbA-1yxaA:
undetectable		 1epbA-1yxaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czt PROSTAGLANDIN-H2
D-ISOMERASE

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  34
TRP A  43
VAL A  69
LEU A  79
VAL A 120
 None
 0.74A 1epbA-2cztA:
18.4		 1epbA-2cztA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czt PROSTAGLANDIN-H2
D-ISOMERASE

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  34
TRP A  43
VAL A  69
VAL A 120
ALA A 129
 None
 0.45A 1epbA-2cztA:
18.4		 1epbA-2cztA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Methanothermobacter
thermautotrophicus) 		PF00710
(Asparaginase) 		5 ILE A 143
VAL A 140
ALA A 159
ILE A  96
ILE A  95
 None
 1.01A 1epbA-2d6fA:
undetectable		 1epbA-2d6fA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj3 PROTEIN
DISULFIDE-ISOMERASE
A4

(Mus musculus) 		PF00085
(Thioredoxin) 		5 PHE A  17
ILE A  72
VAL A  21
ALA A  88
ILE A  62
 None
 1.01A 1epbA-2dj3A:
undetectable		 1epbA-2dj3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 VAL A 272
VAL A 316
ALA A 288
ILE A 285
ILE A 309
 None
 0.98A 1epbA-2e4uA:
undetectable		 1epbA-2e4uA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		5 ILE A 383
VAL A 655
LEU A 366
ILE A 353
ILE A 349
 None
 0.99A 1epbA-2i7xA:
undetectable		 1epbA-2i7xA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jan TYROSYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00579
(tRNA-synt_1b) 		5 MET A  33
VAL A  35
LEU A 190
ALA A  63
ILE A   5
 None
 1.02A 1epbA-2janA:
undetectable		 1epbA-2janA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qos COMPLEMENT COMPONENT
8, GAMMA POLYPEPTIDE

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE C  22
TRP C  31
VAL C  57
VAL C 107
ALA C 116
LYS C 129
 None
 0.91A 1epbA-2qosC:
18.3		 1epbA-2qosC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rir DIPICOLINATE
SYNTHASE, A CHAIN

(Bacillus
subtilis) 		PF01262
(AlaDh_PNT_C)
PF16924
(DpaA_N) 		5 ILE A 224
MET A 233
VAL A 229
LEU A 230
ALA A 158
 None
 0.86A 1epbA-2rirA:
undetectable		 1epbA-2rirA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A 977
VAL A 998
ALA A1018
ILE A1021
ILE A1023
 None
 1.03A 1epbA-2vdcA:
undetectable		 1epbA-2vdcA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcv L-FUCOSE MUTAROTASE

(Escherichia
coli) 		PF05025
(RbsD_FucU) 		5 ILE A  43
MET A  20
VAL A  16
LEU A  17
ALA A 117
 None
 0.89A 1epbA-2wcvA:
undetectable		 1epbA-2wcvA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 199
LEU A 203
LYS A 338
ALA A 307
ILE A 281
 None
 0.98A 1epbA-2wvgA:
undetectable		 1epbA-2wvgA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7s UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		5 ILE A 186
VAL A 166
VAL A 203
ILE A 204
ILE A 208
 None
 0.94A 1epbA-3a7sA:
undetectable		 1epbA-3a7sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2q UNCHARACTERIZED
CONSERVED PROTEIN

(Methanococcus
maripaludis) 		no annotation 5 ILE A 217
LEU A 401
ALA A 239
ILE A 237
ILE A 234
 None
 1.02A 1epbA-3c2qA:
undetectable		 1epbA-3c2qA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 PHE A 302
ILE A 129
LEU A  73
VAL A   9
ALA A  19
 None
 1.04A 1epbA-3dahA:
undetectable		 1epbA-3dahA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etu PROTEIN TRANSPORT
PROTEIN DSL1

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		5 PHE A 284
ILE A 310
VAL A 288
ILE A 295
ILE A 294
 None
 0.90A 1epbA-3etuA:
undetectable		 1epbA-3etuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsa PLECKSTRIN HOMOLOGY
DOMAIN

(Shewanella
amazonensis) 		PF08000
(bPH_1) 		5 ILE A  95
LEU A  53
ALA A 123
ILE A 119
ILE A 115
 None
MLY  A 104 ( 4.8A)
None
None
None
 0.97A 1epbA-3hsaA:
undetectable		 1epbA-3hsaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwr 2-DEHYDROPANTOATE
2-REDUCTASE

(Cupriavidus
pinatubonensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 MET A   1
VAL A   3
LEU A  70
VAL A 163
ALA A 161
 None
 0.95A 1epbA-3hwrA:
undetectable		 1epbA-3hwrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4u BINDING COMPONENT OF
ABC TRANSPORTER

(Wolinella
succinogenes) 		PF00497
(SBP_bac_3) 		6 MET A  40
VAL A  42
VAL A   7
ALA A  33
ILE A  65
ILE A 193
 None
 1.28A 1epbA-3k4uA:
undetectable		 1epbA-3k4uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Thermoanaerobacter
pseudethanolicus) 		PF00724
(Oxidored_FMN) 		5 PHE A 195
ILE A 141
VAL A  61
ILE A 162
ILE A 213
 None
 0.93A 1epbA-3krzA:
undetectable		 1epbA-3krzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lae UPF0053 PROTEIN
HI0107

(Haemophilus
influenzae) 		PF03471
(CorC_HlyC) 		5 ILE A  55
LEU A  16
VAL A  75
ALA A  73
ILE A  10
 None
 1.04A 1epbA-3laeA:
undetectable		 1epbA-3laeA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvk PROTEIN FUCU

(Bifidobacterium
longum) 		PF05025
(RbsD_FucU) 		5 MET A  20
VAL A  16
LEU A  17
VAL A  27
ALA A 122
 None
 0.96A 1epbA-3mvkA:
undetectable		 1epbA-3mvkA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n92 ALPHA-AMYLASE, GH57
FAMILY

(Thermococcus
kodakarensis) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 PHE A 172
LEU A  41
VAL A 138
ILE A  58
ILE A  56
 None
 0.96A 1epbA-3n92A:
undetectable		 1epbA-3n92A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2y PROSTAGLANDIN-H2
D-ISOMERASE

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  34
TRP A  43
VAL A  69
VAL A 120
ALA A 129
 None
 0.61A 1epbA-3o2yA:
18.9		 1epbA-3o2yA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ALA A  17
ILE A 236
 None
 0.88A 1epbA-3ov3A:
undetectable		 1epbA-3ov3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 1.02A 1epbA-3ov3A:
undetectable		 1epbA-3ov3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Entamoeba
histolytica) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ILE A  80
VAL A 101
LEU A  92
VAL A  18
ILE A  54
 None
 1.00A 1epbA-3p91A:
undetectable		 1epbA-3p91A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tny YFIY (ABC TRANSPORT
SYSTEM
SUBSTRATE-BINDING
PROTEIN)

(Bacillus cereus) 		PF01497
(Peripla_BP_2) 		5 PHE A 163
ILE A 236
VAL A 247
VAL A 161
ILE A 158
 None
 1.02A 1epbA-3tnyA:
undetectable		 1epbA-3tnyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		5 VAL A 969
LEU A 957
VAL A 811
ILE A 606
ILE A 609
 None
 1.02A 1epbA-3tsyA:
undetectable		 1epbA-3tsyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		6 PHE A  95
ILE A 102
VAL A  66
VAL A 141
ILE A 150
ILE A  79
 None
 1.16A 1epbA-3v8vA:
undetectable		 1epbA-3v8vA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vml 3-ISOPROPYLMALATE
DEHYDROGENASE

(Shewanella
benthica;
Shewanella
oneidensis) 		PF00180
(Iso_dh) 		6 ILE A  36
LEU A  70
VAL A  28
ALA A 316
ILE A 320
ILE A 300
 None
 1.33A 1epbA-3vmlA:
undetectable		 1epbA-3vmlA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 VAL  A 382 ( 0.6A)
LEU  A 370 ( 0.5A)
VAL  A 224 ( 0.6A)
ILE  A  19 ( 0.7A)
ILE  A  22 ( 0.7A)
 0.97A 1epbA-3wd7A:
undetectable		 1epbA-3wd7A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 0.92A 1epbA-3wd8A:
undetectable		 1epbA-3wd8A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyf RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00638
(Ran_BP1) 		5 PHE B 274
ILE B 268
LEU B 222
VAL B 276
ILE B 290
 None
 1.03A 1epbA-3wyfB:
2.1		 1epbA-3wyfB:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zc1 AFTRAX

(Archaeoglobus
fulgidus) 		PF01997
(Translin) 		5 PHE A 108
VAL A  82
ALA A  86
ILE A  85
ILE A  54
 None
 0.99A 1epbA-3zc1A:
undetectable		 1epbA-3zc1A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bws THIOREDOXIN-LIKE
PROTEIN 4A

(Homo sapiens) 		PF02966
(DIM1) 		5 PHE A  83
ILE A 115
VAL A  27
ALA A  56
ILE A  58
 None
 1.01A 1epbA-4bwsA:
undetectable		 1epbA-4bwsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c84 E3 UBIQUITIN-PROTEIN
LIGASE ZNRF3

(Danio rerio) 		no annotation 5 ILE A 128
VAL A  35
VAL A 168
ALA A 174
ILE A 167
 None
 1.00A 1epbA-4c84A:
undetectable		 1epbA-4c84A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8t E3 UBIQUITIN-PROTEIN
LIGASE ZNRF3

(Xenopus
tropicalis) 		no annotation 5 ILE A 128
VAL A  34
VAL A 168
ALA A 174
ILE A 167
 None
 0.89A 1epbA-4c8tA:
undetectable		 1epbA-4c8tA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdo THIOREDOXIN-LIKE
PROTEIN 4A,
POLYGLUTAMINE-BINDIN
G PROTEIN

(Homo sapiens) 		PF02966
(DIM1) 		5 PHE A  83
ILE A 115
VAL A  27
ALA A  56
ILE A  58
 None
 0.97A 1epbA-4cdoA:
undetectable		 1epbA-4cdoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es7 PROTEIN AMBP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A   9
ILE A  11
VAL A  96
ALA A 105
LYS A 123
 None
 0.75A 1epbA-4es7A:
19.5		 1epbA-4es7A:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es7 PROTEIN AMBP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A   9
TRP A  18
VAL A  96
ALA A 105
LYS A 123
 None
 0.57A 1epbA-4es7A:
19.5		 1epbA-4es7A:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE A1005
MET A1021
VAL A1017
LEU A1018
VAL A 135
 None
 1.04A 1epbA-4f4cA:
undetectable		 1epbA-4f4cA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A  92
VAL A 130
VAL A 150
ALA A 201
ILE A 203
 None
 0.86A 1epbA-4f9oA:
undetectable		 1epbA-4f9oA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnf HEAT-LABILE
ENTEROTOXIN IIB, B
CHAIN

(Escherichia
coli) 		no annotation 6 PHE D   6
VAL D  21
LEU D  23
ALA D  82
ILE D  91
ILE D  49
 None
 1.25A 1epbA-4fnfD:
undetectable		 1epbA-4fnfD:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		5 ILE A  21
MET A 312
VAL A 308
LEU A 309
ILE A  36
 None
 0.83A 1epbA-4hy3A:
undetectable		 1epbA-4hy3A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxk OXIDOREDUCTASE

(Rhodococcus
opacus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 269
LEU A 282
VAL A 161
ALA A 165
ILE A 126
 None
 1.02A 1epbA-4jxkA:
undetectable		 1epbA-4jxkA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9p FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		5 PHE A 611
VAL A 606
VAL A 647
ALA A 581
ILE A 654
 None
 1.00A 1epbA-4m9pA:
undetectable		 1epbA-4m9pA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orx PROSTAGLANDIN-H2
D-ISOMERASE

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  34
TRP A  43
VAL A  69
VAL A 120
ALA A 129
 None
 0.59A 1epbA-4orxA:
19.0		 1epbA-4orxA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8x URICASE

(Bacillus
fastidiosus) 		PF01014
(Uricase) 		6 VAL A 265
LEU A 262
LYS A  26
ALA A 232
ILE A 231
ILE A  28
 None
 1.36A 1epbA-4r8xA:
undetectable		 1epbA-4r8xA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		6 ILE A 260
MET A 124
VAL A  81
LEU A 126
ILE A   7
ILE A 204
 None
 1.28A 1epbA-4r9oA:
undetectable		 1epbA-4r9oA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 1.00A 1epbA-4wumA:
undetectable		 1epbA-4wumA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		5 VAL A 367
LEU A 371
VAL A  14
ILE A 108
ILE A 106
 None
 1.01A 1epbA-4zhtA:
undetectable		 1epbA-4zhtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		5 ILE A 442
MET A 284
VAL A 288
VAL A 684
ILE A 690
 None
 1.03A 1epbA-5amqA:
undetectable		 1epbA-5amqA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 ILE A 324
LEU A  20
VAL A  33
ILE A  66
ILE A  68
 None
 0.99A 1epbA-5c3mA:
undetectable		 1epbA-5c3mA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 ILE A 264
VAL A 310
ALA A 338
ILE A 339
ILE A 317
 None
 1.01A 1epbA-5d6nA:
undetectable		 1epbA-5d6nA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 VAL A2138
LEU A2107
ALA A2133
ILE A2095
ILE A2090
 None
 0.95A 1epbA-5fbyA:
undetectable		 1epbA-5fbyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 MET g 449
VAL g 445
LEU g 427
ALA g 513
ILE g 136
 None
 0.98A 1epbA-5gw4g:
undetectable		 1epbA-5gw4g:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB

(Escherichia
coli) 		PF00072
(Response_reg) 		5 ILE A  19
VAL A   6
VAL A 107
ALA A 119
ILE A 103
 None
 1.00A 1epbA-5i4cA:
undetectable		 1epbA-5i4cA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		6 PHE A 226
ILE A 235
TRP A 206
VAL A 268
ILE A 259
LYS A 291
 None
 1.47A 1epbA-5k5tA:
undetectable		 1epbA-5k5tA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5klp ORF34

(Pseudomonas
syringae) 		PF03421
(Acetyltransf_14) 		5 ILE A 122
VAL A 197
LEU A 199
ALA A 154
ILE A 168
 None
 1.02A 1epbA-5klpA:
undetectable		 1epbA-5klpA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxj L-ASPARTATE OXIDASE

(Salmonella
enterica) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A 500
VAL A 210
LEU A 443
ALA A 226
ILE A 474
 None
 0.99A 1epbA-5kxjA:
undetectable		 1epbA-5kxjA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llb POLYPHOSPHATE KINASE
2

(Francisella
tularensis) 		no annotation 5 PHE C  58
ILE C  70
LEU C  77
ALA C 235
ILE C 239
 None
 1.01A 1epbA-5llbC:
undetectable		 1epbA-5llbC:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6j NITROPHORIN-7

(Rhodnius
prolixus) 		no annotation 5 TRP A  25
VAL A 111
ALA A 119
ILE A 121
ILE A 123
 None
None
None
None
HEM  A 201 (-4.4A)
 0.86A 1epbA-5m6jA:
15.1		 1epbA-5m6jA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my3 RHO
GTPASE-ACTIVATING
PROTEIN RGD1

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A 114
LEU A 110
VAL A  37
ALA A 156
ILE A  40
 None
 1.01A 1epbA-5my3A:
undetectable		 1epbA-5my3A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 5 ILE A 468
LEU A 361
ALA A 475
ILE A 474
ILE A 567
 None
 0.96A 1epbA-5n6vA:
undetectable		 1epbA-5n6vA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 5 ILE A 937
LEU A 901
VAL A 845
ALA A 880
ILE A 823
 CSO  A 938 ( 3.9A)
None
None
None
None
 1.00A 1epbA-5nn8A:
undetectable		 1epbA-5nn8A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o32 COMPLEMENT FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00530
(SRCR) 		5 PHE D 112
VAL D 184
VAL D 114
ALA D 153
ILE D 126
 None
 1.03A 1epbA-5o32D:
undetectable		 1epbA-5o32D:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 5 ILE B  97
LEU B 247
ALA B  45
ILE B  48
ILE B  50
 None
 1.00A 1epbA-5ofbB:
undetectable		 1epbA-5ofbB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy9 GLYCOPROTEIN G

(Indiana
vesiculovirus) 		no annotation 5 PHE A 237
ILE A 186
LEU A 195
VAL A 229
ALA A 218
 None
 1.03A 1epbA-5oy9A:
undetectable		 1epbA-5oy9A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		5 PHE A 402
ILE A 376
VAL A 373
LEU A 369
VAL A 404
 None
 1.03A 1epbA-5szsA:
undetectable		 1epbA-5szsA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1b MTRE
PROTEIN,FERRITIN
CHIMERA

(Helicobacter
pylori;
Neisseria
gonorrhoeae) 		no annotation 5 ILE A 101
LEU A  57
ALA A 108
ILE A   6
ILE A   7
 None
 0.93A 1epbA-5u1bA:
undetectable		 1epbA-5u1bA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A 255
VAL A 273
ALA A 330
ILE A 328
ILE A 326
 None
 1.01A 1epbA-5utuA:
undetectable		 1epbA-5utuA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 VAL 7 410
VAL 7 437
ALA 7 645
ILE 7 642
ILE 7 476
 None
 1.00A 1epbA-5v8f7:
undetectable		 1epbA-5v8f7:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13

(Homo sapiens) 		PF01564
(Spermine_synth) 		5 MET A 573
VAL A 571
LEU A 497
ALA A 479
ILE A 478
 None
 1.02A 1epbA-5wcjA:
undetectable		 1epbA-5wcjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 5 ILE A  17
TRP A 250
ALA A 274
ILE A 286
ILE A 223
 None
 1.00A 1epbA-5z5dA:
undetectable		 1epbA-5z5dA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD

(Bacillus
thuringiensis) 		no annotation 5 PHE A 167
ILE A  17
VAL A 165
ALA A 215
ILE A 148
 None
NAP  A 401 (-3.8A)
None
None
None
 1.00A 1epbA-6bwcA:
undetectable		 1epbA-6bwcA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-) 		no annotation 5 VAL A  46
LEU A  40
ALA A 331
ILE A  60
ILE A  63
 None
 0.94A 1epbA-6gu8A:
undetectable		 1epbA-6gu8A:
undetectable