SIMILAR PATTERNS OF AMINO ACIDS FOR 1EPB_A_9CRA165

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 1.00A 1epbA-1d6hA:
undetectable		 1epbA-1d6hA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei6 PHOSPHONOACETATE
HYDROLASE

(Pseudomonas
fluorescens) 		PF01663
(Phosphodiest) 		5 PHE A 142
ILE A 160
VAL A 123
ALA A 121
ILE A  22
 None
 1.00A 1epbA-1ei6A:
undetectable		 1epbA-1ei6A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hh2 N UTILIZATION
SUBSTANCE PROTEIN A

(Thermotoga
maritima) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		5 TRP P 166
VAL P 142
ALA P 150
ILE P 152
ILE P 154
 None
 0.94A 1epbA-1hh2P:
undetectable		 1epbA-1hh2P:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 VAL A 406
LEU A 404
VAL A 496
ALA A 414
ILE A 398
 None
 1.04A 1epbA-1jedA:
undetectable		 1epbA-1jedA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji0 ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 PHE A 125
VAL A  85
VAL A 180
ILE A 181
ILE A  33
 None
 0.94A 1epbA-1ji0A:
undetectable		 1epbA-1ji0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3g CYTOCHROME C-553

(Sporosarcina
pasteurii) 		PF13442
(Cytochrome_CBB3) 		5 ILE A  33
MET A  71
VAL A  84
ALA A  76
ILE A  64
 None
HEC  A  93 (-2.4A)
HEC  A  93 (-4.2A)
HEC  A  93 ( 3.6A)
HEC  A  93 (-3.6A)
 0.96A 1epbA-1k3gA:
undetectable		 1epbA-1k3gA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A 500
VAL A 210
LEU A 443
ALA A 226
ILE A 474
 None
 0.91A 1epbA-1knrA:
undetectable		 1epbA-1knrA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktj ALLERGEN DER P 2

(Dermatophagoides
pteronyssinus) 		PF02221
(E1_DerP2_DerF2) 		6 ILE A  29
LEU A  37
VAL A  65
ALA A  56
ILE A  54
ILE A  52
 None
 1.24A 1epbA-1ktjA:
0.9		 1epbA-1ktjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktj ALLERGEN DER P 2

(Dermatophagoides
pteronyssinus) 		PF02221
(E1_DerP2_DerF2) 		5 LEU A  37
VAL A 110
ALA A  72
ILE A  52
ILE A  54
 None
 1.00A 1epbA-1ktjA:
0.9		 1epbA-1ktjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1

(Homo sapiens) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LYS A 249
VAL A 253
ALA A 329
ILE A 327
ILE A 325
 None
 0.77A 1epbA-1l1fA:
undetectable		 1epbA-1l1fA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 PHE A  12
ILE A 361
VAL A 335
ALA A 375
ILE A 311
ILE A 292
 None
 1.29A 1epbA-1mewA:
undetectable		 1epbA-1mewA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A1012
VAL A1033
ALA A1053
ILE A1056
ILE A1058
 None
 0.97A 1epbA-1ofeA:
undetectable		 1epbA-1ofeA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A  72
VAL A   5
LEU A  23
ALA A  79
ILE A  81
 None
 1.03A 1epbA-1p43A:
undetectable		 1epbA-1p43A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		5 ILE A  41
LEU A 105
VAL A  38
ALA A  47
ILE A  57
 None
 1.02A 1epbA-1pe9A:
undetectable		 1epbA-1pe9A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 ILE A  11
LEU A  87
VAL A 144
ALA A 243
ILE A 185
 None
 1.01A 1epbA-1spxA:
undetectable		 1epbA-1spxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 385
LEU A 373
VAL A 227
ILE A  21
ILE A  24
 None
 0.92A 1epbA-1u0uA:
undetectable		 1epbA-1u0uA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0x NITROPHORIN 4

(Rhodnius
prolixus) 		PF02087
(Nitrophorin) 		5 PHE A  12
TRP A  23
VAL A 109
ALA A 117
ILE A 119
 None
 0.90A 1epbA-1u0xA:
15.0		 1epbA-1u0xA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uit HUMAN DISCS LARGE 5
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A  49
VAL A  23
ALA A  97
ILE A  95
ILE A  93
 None
 0.91A 1epbA-1uitA:
undetectable		 1epbA-1uitA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v74 COLICIN D IMMUNITY
PROTEIN

(Escherichia
coli) 		PF09204
(Colicin_immun) 		5 PHE B  23
ILE B  27
VAL B  78
ILE B  81
LYS B  84
 None
 1.01A 1epbA-1v74B:
undetectable		 1epbA-1v74B:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE

(Sulfurisphaera
tokodaii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A  28
LYS A  97
VAL A  71
ALA A  89
ILE A  92
 None
 1.01A 1epbA-1wydA:
undetectable		 1epbA-1wydA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwv DER F II

(Dermatophagoides
farinae) 		PF02221
(E1_DerP2_DerF2) 		6 ILE A  29
LEU A  37
VAL A  65
ALA A  56
ILE A  54
ILE A  52
 None
PE3  A1001 (-4.5A)
PE3  A1001 ( 4.0A)
PE3  A1001 ( 4.1A)
PE3  A1001 (-4.8A)
PE3  A1001 ( 4.3A)
 1.09A 1epbA-1xwvA:
undetectable		 1epbA-1xwvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N

(Mus musculus) 		PF00079
(Serpin) 		5 PHE A  54
ILE A  78
VAL A 355
LEU A 205
ILE A  97
 None
 0.95A 1epbA-1yxaA:
undetectable		 1epbA-1yxaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czt PROSTAGLANDIN-H2
D-ISOMERASE

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  34
TRP A  43
VAL A  69
LEU A  79
VAL A 120
 None
 0.74A 1epbA-2cztA:
18.4		 1epbA-2cztA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czt PROSTAGLANDIN-H2
D-ISOMERASE

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  34
TRP A  43
VAL A  69
VAL A 120
ALA A 129
 None
 0.45A 1epbA-2cztA:
18.4		 1epbA-2cztA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Methanothermobacter
thermautotrophicus) 		PF00710
(Asparaginase) 		5 ILE A 143
VAL A 140
ALA A 159
ILE A  96
ILE A  95
 None
 1.01A 1epbA-2d6fA:
undetectable		 1epbA-2d6fA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj3 PROTEIN
DISULFIDE-ISOMERASE
A4

(Mus musculus) 		PF00085
(Thioredoxin) 		5 PHE A  17
ILE A  72
VAL A  21
ALA A  88
ILE A  62
 None
 1.01A 1epbA-2dj3A:
undetectable		 1epbA-2dj3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 VAL A 272
VAL A 316
ALA A 288
ILE A 285
ILE A 309
 None
 0.98A 1epbA-2e4uA:
undetectable		 1epbA-2e4uA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		5 ILE A 383
VAL A 655
LEU A 366
ILE A 353
ILE A 349
 None
 0.99A 1epbA-2i7xA:
undetectable		 1epbA-2i7xA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jan TYROSYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00579
(tRNA-synt_1b) 		5 MET A  33
VAL A  35
LEU A 190
ALA A  63
ILE A   5
 None
 1.02A 1epbA-2janA:
undetectable		 1epbA-2janA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qos COMPLEMENT COMPONENT
8, GAMMA POLYPEPTIDE

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE C  22
TRP C  31
VAL C  57
VAL C 107
ALA C 116
LYS C 129
 None
 0.91A 1epbA-2qosC:
18.3		 1epbA-2qosC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rir DIPICOLINATE
SYNTHASE, A CHAIN

(Bacillus
subtilis) 		PF01262
(AlaDh_PNT_C)
PF16924
(DpaA_N) 		5 ILE A 224
MET A 233
VAL A 229
LEU A 230
ALA A 158
 None
 0.86A 1epbA-2rirA:
undetectable		 1epbA-2rirA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A 977
VAL A 998
ALA A1018
ILE A1021
ILE A1023
 None
 1.03A 1epbA-2vdcA:
undetectable		 1epbA-2vdcA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcv L-FUCOSE MUTAROTASE

(Escherichia
coli) 		PF05025
(RbsD_FucU) 		5 ILE A  43
MET A  20
VAL A  16
LEU A  17
ALA A 117
 None
 0.89A 1epbA-2wcvA:
undetectable		 1epbA-2wcvA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 199
LEU A 203
LYS A 338
ALA A 307
ILE A 281
 None
 0.98A 1epbA-2wvgA:
undetectable		 1epbA-2wvgA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7s UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		5 ILE A 186
VAL A 166
VAL A 203
ILE A 204
ILE A 208
 None
 0.94A 1epbA-3a7sA:
undetectable		 1epbA-3a7sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2q UNCHARACTERIZED
CONSERVED PROTEIN

(Methanococcus
maripaludis) 		no annotation 5 ILE A 217
LEU A 401
ALA A 239
ILE A 237
ILE A 234
 None
 1.02A 1epbA-3c2qA:
undetectable		 1epbA-3c2qA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 PHE A 302
ILE A 129
LEU A  73
VAL A   9
ALA A  19
 None
 1.04A 1epbA-3dahA:
undetectable		 1epbA-3dahA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etu PROTEIN TRANSPORT
PROTEIN DSL1

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		5 PHE A 284
ILE A 310
VAL A 288
ILE A 295
ILE A 294
 None
 0.90A 1epbA-3etuA:
undetectable		 1epbA-3etuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsa PLECKSTRIN HOMOLOGY
DOMAIN

(Shewanella
amazonensis) 		PF08000
(bPH_1) 		5 ILE A  95
LEU A  53
ALA A 123
ILE A 119
ILE A 115
 None
MLY  A 104 ( 4.8A)
None
None
None
 0.97A 1epbA-3hsaA:
undetectable		 1epbA-3hsaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwr 2-DEHYDROPANTOATE
2-REDUCTASE

(Cupriavidus
pinatubonensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 MET A   1
VAL A   3
LEU A  70
VAL A 163
ALA A 161
 None
 0.95A 1epbA-3hwrA:
undetectable		 1epbA-3hwrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4u BINDING COMPONENT OF
ABC TRANSPORTER

(Wolinella
succinogenes) 		PF00497
(SBP_bac_3) 		6 MET A  40
VAL A  42
VAL A   7
ALA A  33
ILE A  65
ILE A 193
 None
 1.28A 1epbA-3k4uA:
undetectable		 1epbA-3k4uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Thermoanaerobacter
pseudethanolicus) 		PF00724
(Oxidored_FMN) 		5 PHE A 195
ILE A 141
VAL A  61
ILE A 162
ILE A 213
 None
 0.93A 1epbA-3krzA:
undetectable		 1epbA-3krzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lae UPF0053 PROTEIN
HI0107

(Haemophilus
influenzae) 		PF03471
(CorC_HlyC) 		5 ILE A  55
LEU A  16
VAL A  75
ALA A  73
ILE A  10
 None
 1.04A 1epbA-3laeA:
undetectable		 1epbA-3laeA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvk PROTEIN FUCU

(Bifidobacterium
longum) 		PF05025
(RbsD_FucU) 		5 MET A  20
VAL A  16
LEU A  17
VAL A  27
ALA A 122
 None
 0.96A 1epbA-3mvkA:
undetectable		 1epbA-3mvkA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n92 ALPHA-AMYLASE, GH57
FAMILY

(Thermococcus
kodakarensis) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 PHE A 172
LEU A  41
VAL A 138
ILE A  58
ILE A  56
 None
 0.96A 1epbA-3n92A:
undetectable		 1epbA-3n92A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2y PROSTAGLANDIN-H2
D-ISOMERASE

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  34
TRP A  43
VAL A  69
VAL A 120
ALA A 129
 None
 0.61A 1epbA-3o2yA:
18.9		 1epbA-3o2yA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ALA A  17
ILE A 236
 None
 0.88A 1epbA-3ov3A:
undetectable		 1epbA-3ov3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 1.02A 1epbA-3ov3A:
undetectable		 1epbA-3ov3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Entamoeba
histolytica) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ILE A  80
VAL A 101
LEU A  92
VAL A  18
ILE A  54
 None
 1.00A 1epbA-3p91A:
undetectable		 1epbA-3p91A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tny YFIY (ABC TRANSPORT
SYSTEM
SUBSTRATE-BINDING
PROTEIN)

(Bacillus cereus) 		PF01497
(Peripla_BP_2) 		5 PHE A 163
ILE A 236
VAL A 247
VAL A 161
ILE A 158
 None
 1.02A 1epbA-3tnyA:
undetectable		 1epbA-3tnyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		5 VAL A 969
LEU A 957
VAL A 811
ILE A 606
ILE A 609
 None
 1.02A 1epbA-3tsyA:
undetectable		 1epbA-3tsyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		6 PHE A  95
ILE A 102
VAL A  66
VAL A 141
ILE A 150
ILE A  79
 None
 1.16A 1epbA-3v8vA:
undetectable		 1epbA-3v8vA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vml 3-ISOPROPYLMALATE
DEHYDROGENASE

(Shewanella
benthica;
Shewanella
oneidensis) 		PF00180
(Iso_dh) 		6 ILE A  36
LEU A  70
VAL A  28
ALA A 316
ILE A 320
ILE A 300
 None
 1.33A 1epbA-3vmlA:
undetectable		 1epbA-3vmlA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 VAL  A 382 ( 0.6A)
LEU  A 370 ( 0.5A)
VAL  A 224 ( 0.6A)
ILE  A  19 ( 0.7A)
ILE  A  22 ( 0.7A)
 0.97A 1epbA-3wd7A:
undetectable		 1epbA-3wd7A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 0.92A 1epbA-3wd8A:
undetectable		 1epbA-3wd8A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyf RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00638
(Ran_BP1) 		5 PHE B 274
ILE B 268
LEU B 222
VAL B 276
ILE B 290
 None
 1.03A 1epbA-3wyfB:
2.1		 1epbA-3wyfB:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zc1 AFTRAX

(Archaeoglobus
fulgidus) 		PF01997
(Translin) 		5 PHE A 108
VAL A  82
ALA A  86
ILE A  85
ILE A  54
 None
 0.99A 1epbA-3zc1A:
undetectable		 1epbA-3zc1A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bws THIOREDOXIN-LIKE
PROTEIN 4A

(Homo sapiens) 		PF02966
(DIM1) 		5 PHE A  83
ILE A 115
VAL A  27
ALA A  56
ILE A  58
 None
 1.01A 1epbA-4bwsA:
undetectable		 1epbA-4bwsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c84 E3 UBIQUITIN-PROTEIN
LIGASE ZNRF3

(Danio rerio) 		no annotation 5 ILE A 128
VAL A  35
VAL A 168
ALA A 174
ILE A 167
 None
 1.00A 1epbA-4c84A:
undetectable		 1epbA-4c84A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8t E3 UBIQUITIN-PROTEIN
LIGASE ZNRF3

(Xenopus
tropicalis) 		no annotation 5 ILE A 128
VAL A  34
VAL A 168
ALA A 174
ILE A 167
 None
 0.89A 1epbA-4c8tA:
undetectable		 1epbA-4c8tA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdo THIOREDOXIN-LIKE
PROTEIN 4A,
POLYGLUTAMINE-BINDIN
G PROTEIN

(Homo sapiens) 		PF02966
(DIM1) 		5 PHE A  83
ILE A 115
VAL A  27
ALA A  56
ILE A  58
 None
 0.97A 1epbA-4cdoA:
undetectable		 1epbA-4cdoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es7 PROTEIN AMBP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A   9
ILE A  11
VAL A  96
ALA A 105
LYS A 123
 None
 0.75A 1epbA-4es7A:
19.5		 1epbA-4es7A:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es7 PROTEIN AMBP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A   9
TRP A  18
VAL A  96
ALA A 105
LYS A 123
 None
 0.57A 1epbA-4es7A:
19.5		 1epbA-4es7A:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE A1005
MET A1021
VAL A1017
LEU A1018
VAL A 135
 None
 1.04A 1epbA-4f4cA:
undetectable		 1epbA-4f4cA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A  92
VAL A 130
VAL A 150
ALA A 201
ILE A 203
 None
 0.86A 1epbA-4f9oA:
undetectable		 1epbA-4f9oA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnf HEAT-LABILE
ENTEROTOXIN IIB, B
CHAIN

(Escherichia
coli) 		no annotation 6 PHE D   6
VAL D  21
LEU D  23
ALA D  82
ILE D  91
ILE D  49
 None
 1.25A 1epbA-4fnfD:
undetectable		 1epbA-4fnfD:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		5 ILE A  21
MET A 312
VAL A 308
LEU A 309
ILE A  36
 None
 0.83A 1epbA-4hy3A:
undetectable		 1epbA-4hy3A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxk OXIDOREDUCTASE

(Rhodococcus
opacus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 269
LEU A 282
VAL A 161
ALA A 165
ILE A 126
 None
 1.02A 1epbA-4jxkA:
undetectable		 1epbA-4jxkA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9p FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		5 PHE A 611
VAL A 606
VAL A 647
ALA A 581
ILE A 654
 None
 1.00A 1epbA-4m9pA:
undetectable		 1epbA-4m9pA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orx PROSTAGLANDIN-H2
D-ISOMERASE

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  34
TRP A  43
VAL A  69
VAL A 120
ALA A 129
 None
 0.59A 1epbA-4orxA:
19.0		 1epbA-4orxA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8x URICASE

(Bacillus
fastidiosus) 		PF01014
(Uricase) 		6 VAL A 265
LEU A 262
LYS A  26
ALA A 232
ILE A 231
ILE A  28
 None
 1.36A 1epbA-4r8xA:
undetectable		 1epbA-4r8xA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		6 ILE A 260
MET A 124
VAL A  81
LEU A 126
ILE A   7
ILE A 204
 None
 1.28A 1epbA-4r9oA:
undetectable		 1epbA-4r9oA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 1.00A 1epbA-4wumA:
undetectable		 1epbA-4wumA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		5 VAL A 367
LEU A 371
VAL A  14
ILE A 108
ILE A 106
 None
 1.01A 1epbA-4zhtA:
undetectable		 1epbA-4zhtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		5 ILE A 442
MET A 284
VAL A 288
VAL A 684
ILE A 690
 None
 1.03A 1epbA-5amqA:
undetectable		 1epbA-5amqA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 ILE A 324
LEU A  20
VAL A  33
ILE A  66
ILE A  68
 None
 0.99A 1epbA-5c3mA:
undetectable		 1epbA-5c3mA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 ILE A 264
VAL A 310
ALA A 338
ILE A 339
ILE A 317
 None
 1.01A 1epbA-5d6nA:
undetectable		 1epbA-5d6nA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 VAL A2138
LEU A2107
ALA A2133
ILE A2095
ILE A2090
 None
 0.95A 1epbA-5fbyA:
undetectable		 1epbA-5fbyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 MET g 449
VAL g 445
LEU g 427
ALA g 513
ILE g 136
 None
 0.98A 1epbA-5gw4g:
undetectable		 1epbA-5gw4g:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB

(Escherichia
coli) 		PF00072
(Response_reg) 		5 ILE A  19
VAL A   6
VAL A 107
ALA A 119
ILE A 103
 None
 1.00A 1epbA-5i4cA:
undetectable		 1epbA-5i4cA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		6 PHE A 226
ILE A 235
TRP A 206
VAL A 268
ILE A 259
LYS A 291
 None
 1.47A 1epbA-5k5tA:
undetectable		 1epbA-5k5tA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5klp ORF34

(Pseudomonas
syringae) 		PF03421
(Acetyltransf_14) 		5 ILE A 122
VAL A 197
LEU A 199
ALA A 154
ILE A 168
 None
 1.02A 1epbA-5klpA:
undetectable		 1epbA-5klpA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxj L-ASPARTATE OXIDASE

(Salmonella
enterica) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A 500
VAL A 210
LEU A 443
ALA A 226
ILE A 474
 None
 0.99A 1epbA-5kxjA:
undetectable		 1epbA-5kxjA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llb POLYPHOSPHATE KINASE
2

(Francisella
tularensis) 		no annotation 5 PHE C  58
ILE C  70
LEU C  77
ALA C 235
ILE C 239
 None
 1.01A 1epbA-5llbC:
undetectable		 1epbA-5llbC:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6j NITROPHORIN-7

(Rhodnius
prolixus) 		no annotation 5 TRP A  25
VAL A 111
ALA A 119
ILE A 121
ILE A 123
 None
None
None
None
HEM  A 201 (-4.4A)
 0.86A 1epbA-5m6jA:
15.1		 1epbA-5m6jA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my3 RHO
GTPASE-ACTIVATING
PROTEIN RGD1

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A 114
LEU A 110
VAL A  37
ALA A 156
ILE A  40
 None
 1.01A 1epbA-5my3A:
undetectable		 1epbA-5my3A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 5 ILE A 468
LEU A 361
ALA A 475
ILE A 474
ILE A 567
 None
 0.96A 1epbA-5n6vA:
undetectable		 1epbA-5n6vA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 5 ILE A 937
LEU A 901
VAL A 845
ALA A 880
ILE A 823
 CSO  A 938 ( 3.9A)
None
None
None
None
 1.00A 1epbA-5nn8A:
undetectable		 1epbA-5nn8A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o32 COMPLEMENT FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00530
(SRCR) 		5 PHE D 112
VAL D 184
VAL D 114
ALA D 153
ILE D 126
 None
 1.03A 1epbA-5o32D:
undetectable		 1epbA-5o32D:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 5 ILE B  97
LEU B 247
ALA B  45
ILE B  48
ILE B  50
 None
 1.00A 1epbA-5ofbB:
undetectable		 1epbA-5ofbB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy9 GLYCOPROTEIN G

(Indiana
vesiculovirus) 		no annotation 5 PHE A 237
ILE A 186
LEU A 195
VAL A 229
ALA A 218
 None
 1.03A 1epbA-5oy9A:
undetectable		 1epbA-5oy9A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		5 PHE A 402
ILE A 376
VAL A 373
LEU A 369
VAL A 404
 None
 1.03A 1epbA-5szsA:
undetectable		 1epbA-5szsA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1b MTRE
PROTEIN,FERRITIN
CHIMERA

(Helicobacter
pylori;
Neisseria
gonorrhoeae) 		no annotation 5 ILE A 101
LEU A  57
ALA A 108
ILE A   6
ILE A   7
 None
 0.93A 1epbA-5u1bA:
undetectable		 1epbA-5u1bA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A 255
VAL A 273
ALA A 330
ILE A 328
ILE A 326
 None
 1.01A 1epbA-5utuA:
undetectable		 1epbA-5utuA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 VAL 7 410
VAL 7 437
ALA 7 645
ILE 7 642
ILE 7 476
 None
 1.00A 1epbA-5v8f7:
undetectable		 1epbA-5v8f7:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13

(Homo sapiens) 		PF01564
(Spermine_synth) 		5 MET A 573
VAL A 571
LEU A 497
ALA A 479
ILE A 478
 None
 1.02A 1epbA-5wcjA:
undetectable		 1epbA-5wcjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 5 ILE A  17
TRP A 250
ALA A 274
ILE A 286
ILE A 223
 None
 1.00A 1epbA-5z5dA:
undetectable		 1epbA-5z5dA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD

(Bacillus
thuringiensis) 		no annotation 5 PHE A 167
ILE A  17
VAL A 165
ALA A 215
ILE A 148
 None
NAP  A 401 (-3.8A)
None
None
None
 1.00A 1epbA-6bwcA:
undetectable		 1epbA-6bwcA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-) 		no annotation 5 VAL A  46
LEU A  40
ALA A 331
ILE A  60
ILE A  63
 None
 0.94A 1epbA-6gu8A:
undetectable		 1epbA-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a1s ORNITHINE
CARBAMOYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 213
ALA A 184
VAL A 160
VAL A 158
 None
 0.77A 1epbA-1a1sA:
undetectable		 1epbA-1a1sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1afi MERP

(Shigella
flexneri) 		PF00403
(HMA) 		4 LEU A   7
ALA A  43
VAL A  36
VAL A  34
 None
 0.79A 1epbA-1afiA:
undetectable		 1epbA-1afiA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao3 VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		4 PHE A 138
LEU A   9
PHE A  32
VAL A 176
 None
 0.90A 1epbA-1ao3A:
0.1		 1epbA-1ao3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)

(Bos taurus) 		PF00246
(Peptidase_M14) 		4 LEU A 107
PHE A  86
VAL A  33
TYR A   9
 None
 0.66A 1epbA-1arlA:
undetectable		 1epbA-1arlA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2p PROTEIN (LECTIN)

(Hyacinthoides
hispanica) 		PF01453
(B_lectin) 		4 LEU A  17
ALA A  65
VAL A  75
TYR A  45
 None
 0.73A 1epbA-1b2pA:
undetectable		 1epbA-1b2pA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)

(Thermotoga
maritima) 		PF01584
(CheW)
PF02518
(HATPase_c)
PF02895
(H-kinase_dim) 		4 LEU A 567
ALA A 612
VAL A 625
VAL A 592
 None
 0.64A 1epbA-1b3qA:
0.0		 1epbA-1b3qA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 ALA A 551
PHE A 539
VAL A 541
VAL A 568
 None
 0.56A 1epbA-1d0nA:
1.2		 1epbA-1d0nA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		4 LEU A 324
ALA A 148
VAL A 192
TYR A 130
 None
 0.58A 1epbA-1e1kA:
undetectable		 1epbA-1e1kA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		4 LEU A  73
ALA A  58
VAL A  96
TYR A  18
 None
 0.68A 1epbA-1hdfA:
undetectable		 1epbA-1hdfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdi PHOSPHOGLYCERATE
KINASE

(Sus scrofa) 		PF00162
(PGK) 		4 LEU A   6
ALA A 184
VAL A 161
VAL A 159
 None
 0.81A 1epbA-1hdiA:
undetectable		 1epbA-1hdiA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		4 LEU B 234
ALA B 239
PHE B 247
VAL B 249
 None
 0.57A 1epbA-1htrB:
undetectable		 1epbA-1htrB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iba GLUCOSE PERMEASE

(Escherichia
coli) 		PF00367
(PTS_EIIB) 		5 LEU A  39
ALA A  71
PHE A  73
VAL A  62
TYR A  87
 None
 1.32A 1epbA-1ibaA:
undetectable		 1epbA-1ibaA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j4a D-LACTATE
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 293
ALA A 258
VAL A 232
VAL A 230
 None
 0.85A 1epbA-1j4aA:
undetectable		 1epbA-1j4aA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01135
(PCMT) 		4 LEU A 108
ALA A  42
PHE A  43
TYR A  49
 None
 0.83A 1epbA-1jg3A:
undetectable		 1epbA-1jg3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn1 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Haemophilus
influenzae) 		PF02542
(YgbB) 		4 PHE A  82
LEU A  45
VAL A 130
VAL A 128
 None
 0.88A 1epbA-1jn1A:
undetectable		 1epbA-1jn1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv4 MAJOR URINARY
PROTEIN 2

(Mus musculus) 		PF00061
(Lipocalin) 		4 LEU A  52
ALA A  71
VAL A  82
TYR A 120
 None
None
None
TZL  A 170 (-4.1A)
 0.57A 1epbA-1jv4A:
17.0		 1epbA-1jv4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6r HYPOTHETICAL PROTEIN
TA0175

(Thermoplasma
acidophilum) 		PF08282
(Hydrolase_3) 		4 PHE A 204
LEU A 170
ALA A   5
VAL A  38
 None
 0.87A 1epbA-1l6rA:
undetectable		 1epbA-1l6rA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 LEU A 317
ALA A 150
VAL A 194
TYR A 132
 None
 0.73A 1epbA-1lqtA:
undetectable		 1epbA-1lqtA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7j PHENYLETHANOLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		4 LEU A 262
VAL A 269
VAL A 272
TYR A  85
 None
None
None
SAH  A2002 (-4.6A)
 0.82A 1epbA-1n7jA:
undetectable		 1epbA-1n7jA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		4 ALA A 551
PHE A 539
VAL A 541
VAL A 568
 None
 0.47A 1epbA-1nphA:
undetectable		 1epbA-1nphA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata) 		PF02932
(Neur_chan_memb) 		4 PHE B 293
ALA B 235
VAL B 238
VAL B 301
 None
 0.73A 1epbA-1oedB:
undetectable		 1epbA-1oedB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p90 HYPOTHETICAL PROTEIN

(Azotobacter
vinelandii) 		PF02579
(Nitro_FeMo-Co) 		4 LEU A 169
ALA A 109
PHE A 128
VAL A 130
 None
 0.87A 1epbA-1p90A:
undetectable		 1epbA-1p90A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q40 MRNA TRANSPORT
REGULATOR MTR2

(Candida
albicans) 		PF10429
(Mtr2) 		4 LEU A  85
ALA A 105
VAL A 146
VAL A 148
 None
 0.87A 1epbA-1q40A:
undetectable		 1epbA-1q40A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd6 PROTEIN (OUTER
MEMBRANE
PHOSPHOLIPASE
(OMPLA))

(Escherichia
coli) 		PF02253
(PLA1) 		4 LEU C 133
ALA C 164
VAL C 171
VAL C 173
 None
 0.88A 1epbA-1qd6C:
2.4		 1epbA-1qd6C:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfj PROTEIN (FLAVIN
REDUCTASE)

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 192
ALA A 219
PHE A 213
TYR A 198
 None
 0.86A 1epbA-1qfjA:
undetectable		 1epbA-1qfjA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos) 		4 ALA B 146
PHE B 157
VAL B 159
VAL B 196
 None
 0.89A 1epbA-1sr4B:
undetectable		 1epbA-1sr4B:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 191
ALA A 196
VAL A 178
VAL A 156
 None
 0.86A 1epbA-1tt7A:
undetectable		 1epbA-1tt7A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		4 PHE A 223
ALA A 268
VAL A 241
VAL A 203
 None
 0.90A 1epbA-1up2A:
undetectable		 1epbA-1up2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		4 LEU A 129
PHE A 151
VAL A 153
VAL A 186
 None
 0.90A 1epbA-1vcgA:
undetectable		 1epbA-1vcgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Nostoc sp. PCC
7120) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 LEU A 320
ALA A 319
VAL A 337
VAL A 276
 None
 0.90A 1epbA-1vquA:
undetectable		 1epbA-1vquA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wo8 METHYLGLYOXAL
SYNTHASE

(Thermus
thermophilus) 		PF02142
(MGS) 		4 LEU A  33
ALA A   5
VAL A  76
VAL A  68
 None
 0.90A 1epbA-1wo8A:
undetectable		 1epbA-1wo8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs3 HYPOTHETICAL PROTEIN
XC975

(Xanthomonas
euvesicatoria) 		PF01722
(BolA) 		4 LEU A  81
ALA A  45
VAL A  35
VAL A  33
 None
 0.79A 1epbA-1xs3A:
undetectable		 1epbA-1xs3A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		4 PHE A 173
PHE A  66
VAL A  68
VAL A 185
 None
 0.85A 1epbA-1ytmA:
undetectable		 1epbA-1ytmA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuo HYPOTHETICAL PROTEIN
LOC92912

(Homo sapiens) 		PF00179
(UQ_con) 		4 PHE A 272
LEU A 209
ALA A 205
PHE A 278
 None
 0.84A 1epbA-1zuoA:
undetectable		 1epbA-1zuoA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 PHE A 118
ALA A 154
VAL A 159
TYR A  77
 None
 0.90A 1epbA-2afbA:
undetectable		 1epbA-2afbA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 ALA A 109
PHE A 111
VAL A  57
VAL A  55
 None
 0.85A 1epbA-2b39A:
undetectable		 1epbA-2b39A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cda GLUCOSE
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		5 PHE A 123
ALA A 149
PHE A 313
VAL A 317
VAL A 136
 None
 1.27A 1epbA-2cdaA:
undetectable		 1epbA-2cdaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A  68
ALA A  73
VAL A  28
VAL A   5
 None
 0.85A 1epbA-2cduA:
undetectable		 1epbA-2cduA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7u ADENYLOSUCCINATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00709
(Adenylsucc_synt) 		4 LEU A  69
ALA A  33
VAL A 175
VAL A 173
 None
 0.65A 1epbA-2d7uA:
undetectable		 1epbA-2d7uA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7u ADENYLOSUCCINATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00709
(Adenylsucc_synt) 		4 LEU A 322
ALA A 281
VAL A 220
VAL A   6
 None
 0.65A 1epbA-2d7uA:
undetectable		 1epbA-2d7uA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyx V-CRK SARCOMA VIRUS
CT10 ONCOGENE
HOMOLOG ISOFORM A

(Homo sapiens) 		PF07653
(SH3_2) 		4 LEU A 293
ALA A 240
VAL A 264
VAL A 266
 None
 0.76A 1epbA-2eyxA:
undetectable		 1epbA-2eyxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhx SPM-1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 ALA B  45
PHE B  53
VAL B  55
VAL B  73
 None
 0.75A 1epbA-2fhxB:
undetectable		 1epbA-2fhxB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 218
ALA A 226
PHE A 228
VAL A 149
 None
 0.90A 1epbA-2glxA:
undetectable		 1epbA-2glxA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG

(Escherichia
coli) 		PF13098
(Thioredoxin_2) 		4 LEU A 195
ALA A 197
PHE A 104
TYR A 205
 None
 0.78A 1epbA-2h0iA:
undetectable		 1epbA-2h0iA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350

(Human
gammaherpesvirus
4) 		PF05109
(Herpes_BLLF1) 		4 LEU A  63
ALA A  48
VAL A 130
VAL A 128
 None
 0.63A 1epbA-2h6oA:
undetectable		 1epbA-2h6oA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 LEU A  55
ALA A  70
VAL A  79
VAL A 128
 None
 0.86A 1epbA-2hakA:
undetectable		 1epbA-2hakA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 LEU A 296
ALA A 299
VAL A 233
VAL A 265
 None
 0.87A 1epbA-2iyfA:
undetectable		 1epbA-2iyfA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5u MREC PROTEIN

(Listeria
monocytogenes) 		PF04085
(MreC) 		4 PHE A 194
LEU A 209
ALA A 256
VAL A 245
 None
 0.83A 1epbA-2j5uA:
undetectable		 1epbA-2j5uA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkh PUTATIVE HEAVY METAL
TRANSPORTER

(Arabidopsis
thaliana) 		no annotation 4 ALA A  82
PHE A  21
VAL A  23
VAL A  57
 None
 0.83A 1epbA-2kkhA:
undetectable		 1epbA-2kkhA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9c DARCIN

(Mus musculus) 		PF00061
(Lipocalin) 		4 LEU A  71
ALA A  90
VAL A 101
TYR A 139
 None
 0.68A 1epbA-2l9cA:
13.9		 1epbA-2l9cA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkn AH
RECEPTOR-INTERACTING
PROTEIN

(Homo sapiens) 		PF00254
(FKBP_C) 		5 PHE A 150
LEU A  62
ALA A  34
PHE A  36
VAL A 157
 None
 1.46A 1epbA-2lknA:
undetectable		 1epbA-2lknA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqb COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		4 LEU A  11
ALA A  47
VAL A  40
VAL A  38
 None
 0.84A 1epbA-2lqbA:
undetectable		 1epbA-2lqbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m2b RNA-BINDING PROTEIN
10

(Homo sapiens) 		PF00076
(RRM_1) 		4 LEU A  28
ALA A  70
VAL A  57
VAL A  55
 None
 0.89A 1epbA-2m2bA:
undetectable		 1epbA-2m2bA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00590
(TP_methylase) 		4 LEU A  34
PHE A 106
VAL A 108
VAL A   6
 None
 0.72A 1epbA-2npnA:
undetectable		 1epbA-2npnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 786
ALA A 792
PHE A 758
VAL A 762
 None
 0.82A 1epbA-2ogvA:
undetectable		 1epbA-2ogvA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozu HISTONE
ACETYLTRANSFERASE
MYST3

(Homo sapiens) 		PF01853
(MOZ_SAS) 		4 ALA A 567
PHE A 579
VAL A 581
VAL A 617
 None
 0.85A 1epbA-2ozuA:
undetectable		 1epbA-2ozuA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		4 LEU A   6
ALA A 184
VAL A 161
VAL A 159
 None
 0.63A 1epbA-2paaA:
undetectable		 1epbA-2paaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfy PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		4 LEU A 137
ALA A 158
PHE A 142
VAL A 159
 None
 0.84A 1epbA-2pfyA:
undetectable		 1epbA-2pfyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pim PHENYLACETIC ACID
DEGRADATION-RELATED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF13622
(4HBT_3) 		4 LEU A  87
ALA A 132
VAL A 116
TYR A  42
 None
 0.76A 1epbA-2pimA:
2.9		 1epbA-2pimA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3l UNCHARACTERIZED
PROTEIN

(Shewanella
loihica) 		PF11964
(SpoIIAA-like) 		4 LEU A  21
ALA A  55
VAL A  87
TYR A  34
 None
None
None
MPD  A 129 (-4.3A)
 0.78A 1epbA-2q3lA:
undetectable		 1epbA-2q3lA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r73 TRICHOSURIN

(Trichosurus
vulpecula) 		PF00061
(Lipocalin) 		4 LEU A  61
ALA A  80
PHE A  89
VAL A  99
 None
 0.85A 1epbA-2r73A:
15.0		 1epbA-2r73A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rog HEAVY METAL BINDING
PROTEIN

(Thermus
thermophilus) 		PF00403
(HMA) 		4 LEU A   4
ALA A  40
VAL A  33
VAL A  18
 None
 0.90A 1epbA-2rogA:
undetectable		 1epbA-2rogA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A  85
ALA A  65
PHE A  37
VAL A  39
 None
None
None
IN5  A1394 (-4.6A)
 0.85A 1epbA-2vd9A:
undetectable		 1epbA-2vd9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Bacillus
subtilis) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		4 LEU A  90
ALA A 116
VAL A 133
VAL A 128
 None
 0.74A 1epbA-2vt2A:
undetectable		 1epbA-2vt2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfb PUTATIVE
UNCHARACTERIZED
PROTEIN ORP

(Desulfovibrio
gigas) 		PF02579
(Nitro_FeMo-Co) 		4 ALA A   8
PHE A  30
VAL A  32
VAL A  43
 None
 0.72A 1epbA-2wfbA:
undetectable		 1epbA-2wfbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 PHE A  42
PHE A  93
VAL A  91
VAL A  77
 None
 0.88A 1epbA-2x2iA:
1.5		 1epbA-2x2iA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		5 PHE A 368
LEU A 454
ALA A 449
VAL A 445
VAL A 392
 None
 1.44A 1epbA-2x2iA:
1.5		 1epbA-2x2iA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmr PROTEIN NDRG2

(Homo sapiens) 		PF03096
(Ndr) 		5 LEU A  52
ALA A  50
VAL A  82
VAL A  40
TYR A 120
 None
 1.48A 1epbA-2xmrA:
undetectable		 1epbA-2xmrA:
18.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xst LIPOCALIN 15

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  71
PHE A  99
VAL A 101
VAL A 109
 None
 0.64A 1epbA-2xstA:
18.1		 1epbA-2xstA:
31.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y93 CIS-2,3-DIHYDROBIPHE
NYL-2,3-DIOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF00106
(adh_short) 		4 LEU A   9
ALA A  33
VAL A  54
VAL A  56
 None
 0.75A 1epbA-2y93A:
undetectable		 1epbA-2y93A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvt HYPOTHETICAL PROTEIN
AQ_1956

(Aquifex
aeolicus) 		PF14582
(Metallophos_3) 		4 PHE A 134
PHE A  93
VAL A  95
VAL A  37
 None
 0.90A 1epbA-2yvtA:
undetectable		 1epbA-2yvtA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 PHE A 296
LEU A 326
VAL A 265
VAL A 262
 None
 0.86A 1epbA-2yxxA:
undetectable		 1epbA-2yxxA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 299
ALA A 324
PHE A 321
VAL A 317
 None
 0.90A 1epbA-3a9vA:
undetectable		 1epbA-3a9vA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai2 NADPH-SORBOSE
REDUCTASE

(Gluconobacter
frateurii) 		PF13561
(adh_short_C2) 		4 LEU A 127
ALA A  86
VAL A   9
VAL A  35
 None
 0.81A 1epbA-3ai2A:
undetectable		 1epbA-3ai2A:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 LEU A 140
ALA A 143
VAL A  64
TYR A 112
 None
GOL  A 146 ( 4.6A)
GOL  A 146 ( 4.8A)
GOL  A 145 (-4.4A)
 0.83A 1epbA-3b8lA:
undetectable		 1epbA-3b8lA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE

(Streptomyces
venezuelae) 		PF13649
(Methyltransf_25) 		4 LEU A  42
ALA A 101
VAL A 134
VAL A 136
 None
 0.69A 1epbA-3bxoA:
undetectable		 1epbA-3bxoA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0u UNCHARACTERIZED
PROTEIN YAEQ

(Escherichia
coli) 		PF07152
(YaeQ) 		4 LEU A 163
ALA A 154
VAL A  14
VAL A  12
 None
 0.81A 1epbA-3c0uA:
undetectable		 1epbA-3c0uA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		4 LEU A 132
ALA A 239
PHE A 214
VAL A 216
 None
 0.79A 1epbA-3d2lA:
undetectable		 1epbA-3d2lA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21

(Actinoplanes
teichomyceticus) 		PF02585
(PIG-L) 		4 LEU A 150
ALA A  12
VAL A  40
VAL A  38
 None
 0.61A 1epbA-3dfiA:
undetectable		 1epbA-3dfiA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl3 TELLURITE RESISTANCE
PROTEIN B

(Aliivibrio
fischeri) 		PF09313
(DUF1971) 		4 LEU A  86
ALA A  90
PHE A  92
VAL A  44
 None
 0.82A 1epbA-3dl3A:
undetectable		 1epbA-3dl3A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU B 210
VAL B 181
VAL B 179
TYR B 301
 None
 0.67A 1epbA-3dm9B:
undetectable		 1epbA-3dm9B:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evn OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
agalactiae) 		PF01408
(GFO_IDH_MocA) 		4 PHE A 111
LEU A  88
ALA A  87
VAL A  73
 None
 0.90A 1epbA-3evnA:
undetectable		 1epbA-3evnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		4 ALA A 267
PHE A 112
VAL A 110
VAL A 250
 None
 0.75A 1epbA-3ez6A:
undetectable		 1epbA-3ez6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1c PUTATIVE
2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
2

(Listeria
monocytogenes) 		PF01128
(IspD) 		4 LEU A 129
ALA A 128
VAL A 134
VAL A 107
 None
 0.90A 1epbA-3f1cA:
undetectable		 1epbA-3f1cA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE

(Salmonella
enterica) 		PF00215
(OMPdecase) 		4 LEU A  73
ALA A  78
VAL A  56
VAL A  31
 None
 0.90A 1epbA-3f4wA:
undetectable		 1epbA-3f4wA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 LEU A 477
ALA A 471
PHE A 469
VAL A 352
VAL A 354
 None
 1.18A 1epbA-3fahA:
undetectable		 1epbA-3fahA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU A 292
ALA A 291
PHE A 277
VAL A 279
 None
 0.90A 1epbA-3fr8A:
undetectable		 1epbA-3fr8A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gle PILIN

(Streptococcus
pyogenes) 		PF12892
(FctA) 		4 PHE A 194
ALA A 227
VAL A 210
VAL A 245
 PHE  A 194 ( 1.3A)
ALA  A 227 ( 0.0A)
VAL  A 210 ( 0.6A)
VAL  A 245 ( 0.5A)
 0.60A 1epbA-3gleA:
undetectable		 1epbA-3gleA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		4 LEU A  86
PHE A  69
VAL A  67
VAL A  18
 None
 0.71A 1epbA-3go7A:
undetectable		 1epbA-3go7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		4 ALA A  88
PHE A  68
VAL A  70
VAL A  61
 None
 0.79A 1epbA-3gs9A:
undetectable		 1epbA-3gs9A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		5 PHE A 197
LEU A 111
ALA A 110
VAL A 252
VAL A 244
 None
 1.35A 1epbA-3h14A:
undetectable		 1epbA-3h14A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		4 LEU A 194
ALA A 249
PHE A 231
VAL A 233
 None
 0.73A 1epbA-3h2bA:
undetectable		 1epbA-3h2bA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		4 ALA A 172
PHE A 144
VAL A 146
VAL A 120
 None
 0.87A 1epbA-3h7tA:
undetectable		 1epbA-3h7tA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 PHE A 903
ALA A 924
PHE A 659
VAL A 922
VAL A 913
 None
 1.35A 1epbA-3hmjA:
undetectable		 1epbA-3hmjA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		4 PHE B 311
ALA B 189
VAL B 205
VAL B 202
 None
 0.87A 1epbA-3hrdB:
undetectable		 1epbA-3hrdB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxl UNCHARACTERIZED
PROTEIN DSY3957

(Desulfitobacterium
hafniense) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 LEU A 405
ALA A 420
VAL A 433
VAL A 435
 None
 0.77A 1epbA-3hxlA:
undetectable		 1epbA-3hxlA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		5 PHE A 304
LEU A  47
ALA A 102
PHE A  89
VAL A 103
 None
 1.47A 1epbA-3i3lA:
undetectable		 1epbA-3i3lA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ia7 CALG4

(Micromonospora
echinospora) 		PF00201
(UDPGT) 		4 LEU A 294
ALA A 297
VAL A 232
VAL A 263
 None
 0.87A 1epbA-3ia7A:
undetectable		 1epbA-3ia7A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib7 ICC PROTEIN

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		4 LEU A 168
ALA A 205
VAL A 223
VAL A 221
 None
 0.89A 1epbA-3ib7A:
undetectable		 1epbA-3ib7A:
21.12