SIMILAR PATTERNS OF AMINO ACIDS FOR 1EKJ_G_CUG2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ekj BETA-CARBONIC
ANHYDRASE

(Pisum sativum) 		PF00484
(Pro_CA) 		4 CYH A 166
PRO A 167
SER A 168
ARG A 182
 None
 0.87A 1ekjG-1ekjA:
31.6
1ekjH-1ekjA:
32.7		 1ekjG-1ekjA:
100.00
1ekjH-1ekjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		4 CYH C 103
PRO C 104
SER C 102
CYH C  42
 SF4  C1413 (-2.3A)
None
SF4  C1413 (-4.7A)
SF4  C1413 (-2.3A)
 1.16A 1ekjG-2ynmC:
3.9
1ekjH-2ynmC:
2.5		 1ekjG-2ynmC:
19.04
1ekjH-2ynmC:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		4 CYH A 112
PRO A 113
SER A 111
CYH A  51
 SF4  A 425 (-2.4A)
SF4  A 425 (-4.5A)
None
SF4  A 425 (-2.5A)
 1.25A 1ekjG-3aeuA:
4.2
1ekjH-3aeuA:
2.4		 1ekjG-3aeuA:
20.51
1ekjH-3aeuA:
20.51