SIMILAR PATTERNS OF AMINO ACIDS FOR 1EKJ_G_ACTG3009

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		4 LEU A 262
THR A 263
ARG A  46
VAL A  48
 None
 1.04A 1ekjF-1bf6A:
undetectable
1ekjG-1bf6A:
0.5		 1ekjF-1bf6A:
22.30
1ekjG-1bf6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmg RIBOSOMAL PROTEIN L4

(Thermotoga
maritima) 		PF00573
(Ribosomal_L4) 		4 GLY A 171
LEU A 139
THR A 136
VAL A 177
 None
 1.13A 1ekjF-1dmgA:
undetectable
1ekjG-1dmgA:
undetectable		 1ekjF-1dmgA:
20.16
1ekjG-1dmgA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)

(Aspergillus
nidulans) 		PF01761
(DHQ_synthase) 		4 GLY A 191
LEU A 141
THR A 140
VAL A 195
 None
None
NAD  A 400 (-2.7A)
None
 1.10A 1ekjF-1dqsA:
undetectable
1ekjG-1dqsA:
2.1		 1ekjF-1dqsA:
21.09
1ekjG-1dqsA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 GLY A 139
LEU A 128
THR A 129
VAL A 168
 None
 1.01A 1ekjF-1eovA:
undetectable
1ekjG-1eovA:
undetectable		 1ekjF-1eovA:
18.14
1ekjG-1eovA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A 158
THR A 157
ARG A 116
VAL A 120
 None
 1.09A 1ekjF-1hkkA:
undetectable
1ekjG-1hkkA:
1.4		 1ekjF-1hkkA:
21.11
1ekjG-1hkkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		4 GLY A 125
LEU A 126
THR A 157
VAL A 142
 None
 1.07A 1ekjF-1idjA:
undetectable
1ekjG-1idjA:
undetectable		 1ekjF-1idjA:
23.03
1ekjG-1idjA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1

(Streptomyces
coelicolor) 		PF01183
(Glyco_hydro_25) 		4 GLY A  60
LEU A  93
THR A  92
VAL A  96
 None
 1.09A 1ekjF-1jfxA:
0.8
1ekjG-1jfxA:
0.8		 1ekjF-1jfxA:
21.14
1ekjG-1jfxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 GLY A 259
LEU A 262
THR A 263
VAL A 277
 None
 0.76A 1ekjF-1o2dA:
undetectable
1ekjG-1o2dA:
2.1		 1ekjF-1o2dA:
22.96
1ekjG-1o2dA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE

(Saccharomyces
cerevisiae) 		PF01259
(SAICAR_synt) 		4 GLY A  54
LEU A  57
THR A  58
VAL A  20
 None
None
None
SO4  A 311 (-3.4A)
 1.07A 1ekjF-1obgA:
undetectable
1ekjG-1obgA:
undetectable		 1ekjF-1obgA:
24.04
1ekjG-1obgA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Escherichia
coli) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 GLY A 241
LEU A 237
THR A 238
VAL A 222
 None
 0.98A 1ekjF-1oj4A:
undetectable
1ekjG-1oj4A:
undetectable		 1ekjF-1oj4A:
20.89
1ekjG-1oj4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1om2 PROTEIN
(MITOCHONDRIAL
IMPORT RECEPTOR
SUBUNIT TOM20)

(Rattus
norvegicus) 		PF02064
(MAS20) 		4 GLY A  39
LEU A  43
THR A  44
VAL A  68
 None
 1.05A 1ekjF-1om2A:
undetectable
1ekjG-1om2A:
undetectable		 1ekjF-1om2A:
16.43
1ekjG-1om2A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		4 GLY A 102
LEU A 103
THR A 104
VAL A  78
 None
None
SAH  A 887 (-4.5A)
None
 1.11A 1ekjF-1r6aA:
undetectable
1ekjG-1r6aA:
2.0		 1ekjF-1r6aA:
21.50
1ekjG-1r6aA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		4 GLY A 578
LEU A 595
THR A 591
VAL A 613
 None
 0.95A 1ekjF-1u2lA:
undetectable
1ekjG-1u2lA:
undetectable		 1ekjF-1u2lA:
22.70
1ekjG-1u2lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE

(Thermus
thermophilus) 		PF01761
(DHQ_synthase) 		4 GLY A  93
LEU A  96
THR A  97
VAL A  39
 None
 0.92A 1ekjF-1ujnA:
3.0
1ekjG-1ujnA:
3.2		 1ekjF-1ujnA:
21.91
1ekjG-1ujnA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A 158
THR A 157
ARG A 116
VAL A 120
 None
SO4  A 469 (-4.3A)
SO4  A 469 (-3.7A)
None
 1.07A 1ekjF-1wb0A:
undetectable
1ekjG-1wb0A:
undetectable		 1ekjF-1wb0A:
19.55
1ekjG-1wb0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x57 ENDOTHELIAL
DIFFERENTIATION-RELA
TED FACTOR 1

(Homo sapiens) 		PF01381
(HTH_3) 		4 GLY A  26
LEU A  27
THR A  28
ARG A  22
 None
 1.10A 1ekjF-1x57A:
undetectable
1ekjG-1x57A:
undetectable		 1ekjF-1x57A:
17.81
1ekjG-1x57A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv2 HYPOTHETICAL
PROTEIN, SIMILAR TO
ALPHA-ACETOLACTATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF03306
(AAL_decarboxy) 		4 GLY A 166
LEU A  11
THR A  10
VAL A 226
 None
 0.82A 1ekjF-1xv2A:
undetectable
1ekjG-1xv2A:
undetectable		 1ekjF-1xv2A:
20.48
1ekjG-1xv2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00266
(Aminotran_5) 		4 GLY A 317
LEU A 318
THR A 319
VAL A 146
 None
 1.06A 1ekjF-2bkwA:
2.0
1ekjG-2bkwA:
2.0		 1ekjF-2bkwA:
23.68
1ekjG-2bkwA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c27 MYCOTHIOL SYNTHASE

(Mycobacterium
tuberculosis) 		PF00583
(Acetyltransf_1) 		4 GLY A 250
LEU A 253
THR A 254
VAL A 240
 COA  A1314 (-3.3A)
None
None
COA  A1314 (-4.0A)
 0.93A 1ekjF-2c27A:
undetectable
1ekjG-2c27A:
undetectable		 1ekjF-2c27A:
22.86
1ekjG-2c27A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE

(Mycobacterium
tuberculosis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 GLY A 175
LEU A 178
THR A 179
VAL A 163
 None
 0.80A 1ekjF-2c2yA:
undetectable
1ekjG-2c2yA:
undetectable		 1ekjF-2c2yA:
22.11
1ekjG-2c2yA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy9 THIOESTERASE
SUPERFAMILY MEMBER 2

(Mus musculus) 		PF03061
(4HBT) 		4 GLY A 139
LEU A 138
THR A 112
VAL A  82
 None
 1.10A 1ekjF-2cy9A:
undetectable
1ekjG-2cy9A:
undetectable		 1ekjF-2cy9A:
19.81
1ekjG-2cy9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		4 GLY A 167
LEU A 245
THR A 246
VAL A 242
 None
 1.08A 1ekjF-2d4eA:
1.9
1ekjG-2d4eA:
undetectable		 1ekjF-2d4eA:
18.06
1ekjG-2d4eA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		4 GLY A 138
LEU A 143
THR A 142
VAL A 181
 None
 0.97A 1ekjF-2ejaA:
undetectable
1ekjG-2ejaA:
undetectable		 1ekjF-2ejaA:
21.14
1ekjG-2ejaA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLY A 106
LEU A  12
THR A   8
VAL A 346
 None
 0.94A 1ekjF-2f7vA:
undetectable
1ekjG-2f7vA:
undetectable		 1ekjF-2f7vA:
20.92
1ekjG-2f7vA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdq YITF

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 100
THR A 101
ARG A  78
VAL A  82
 None
 1.11A 1ekjF-2gdqA:
undetectable
1ekjG-2gdqA:
undetectable		 1ekjF-2gdqA:
18.94
1ekjG-2gdqA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4u THIOESTERASE
SUPERFAMILY MEMBER 2

(Homo sapiens) 		PF03061
(4HBT) 		4 GLY A 139
LEU A 138
THR A 112
VAL A  82
 None
 1.11A 1ekjF-2h4uA:
undetectable
1ekjG-2h4uA:
undetectable		 1ekjF-2h4uA:
18.34
1ekjG-2h4uA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		4 LEU A 204
THR A 205
ARG A 216
VAL A 197
 CL  A 501 (-4.9A)
None
None
None
 1.09A 1ekjF-2hxvA:
undetectable
1ekjG-2hxvA:
undetectable		 1ekjF-2hxvA:
21.88
1ekjG-2hxvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llk CYCLIN-D-BINDING
MYB-LIKE
TRANSCRIPTION FACTOR
1

(Homo sapiens) 		PF00249
(Myb_DNA-binding) 		4 GLY A 250
LEU A 253
ARG A 255
VAL A 260
 None
 1.11A 1ekjF-2llkA:
undetectable
1ekjG-2llkA:
undetectable		 1ekjF-2llkA:
16.19
1ekjG-2llkA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lyi PROTEIN (ENTITY)

(Nephila
antipodiana) 		PF12042
(RP1-2) 		4 GLY A   5
LEU A   8
THR A   9
VAL A  93
 None
 0.96A 1ekjF-2lyiA:
undetectable
1ekjG-2lyiA:
undetectable		 1ekjF-2lyiA:
24.24
1ekjG-2lyiA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5u UDP-GLUCOSE
4-EPIMERASE

(Thermus
thermophilus) 		PF01370
(Epimerase) 		4 GLY A 299
LEU A 302
THR A 303
VAL A 294
 None
 1.08A 1ekjF-2p5uA:
undetectable
1ekjG-2p5uA:
2.2		 1ekjF-2p5uA:
19.62
1ekjG-2p5uA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I

(Escherichia
coli) 		PF00365
(PFK) 		4 LEU A  28
THR A  29
ARG A  54
VAL A  57
 None
 0.93A 1ekjF-2pfkA:
2.4
1ekjG-2pfkA:
undetectable		 1ekjF-2pfkA:
20.12
1ekjG-2pfkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7v THIOREDOXIN
REDUCTASE

(Deinococcus
radiodurans) 		PF07992
(Pyr_redox_2) 		4 GLY A 168
LEU A 171
THR A 172
VAL A 157
 None
 0.73A 1ekjF-2q7vA:
undetectable
1ekjG-2q7vA:
undetectable		 1ekjF-2q7vA:
22.42
1ekjG-2q7vA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ver AFIMBRIAL ADHESIN
AFA-III

(Escherichia
coli) 		PF04619
(Adhesin_Dr) 		4 GLY A 136
LEU A 116
THR A 117
VAL A  28
 None
 1.04A 1ekjF-2verA:
undetectable
1ekjG-2verA:
undetectable		 1ekjF-2verA:
21.43
1ekjG-2verA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whd THIOREDOXIN
REDUCTASE

(Hordeum vulgare) 		PF07992
(Pyr_redox_2) 		4 GLY A 173
LEU A 176
THR A 177
VAL A 162
 None
 0.84A 1ekjF-2whdA:
undetectable
1ekjG-2whdA:
undetectable		 1ekjF-2whdA:
20.17
1ekjG-2whdA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 GLY A 527
LEU A 526
THR A 525
VAL A 631
 None
 0.89A 1ekjF-2xqyA:
undetectable
1ekjG-2xqyA:
undetectable		 1ekjF-2xqyA:
16.26
1ekjG-2xqyA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bil PROBABLE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF13407
(Peripla_BP_4) 		4 GLY A 274
LEU A 288
THR A 289
VAL A 255
 None
 1.02A 1ekjF-3bilA:
2.8
1ekjG-3bilA:
3.1		 1ekjF-3bilA:
18.31
1ekjG-3bilA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN

(Idiomarina
baltica) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		4 GLY A 209
LEU A 210
THR A 211
ARG A 237
 None
 0.94A 1ekjF-3bq9A:
undetectable
1ekjG-3bq9A:
undetectable		 1ekjF-3bq9A:
18.68
1ekjG-3bq9A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyv UROPORPHYRINOGEN
DECARBOXYLASE

(Shigella
flexneri) 		PF01208
(URO-D) 		4 GLY A 146
LEU A 151
THR A 150
VAL A 189
 None
 0.84A 1ekjF-3cyvA:
undetectable
1ekjG-3cyvA:
undetectable		 1ekjF-3cyvA:
21.47
1ekjG-3cyvA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1n POU DOMAIN, CLASS 6,
TRANSCRIPTION FACTOR
1

(Homo sapiens) 		PF00046
(Homeobox)
PF00157
(Pou) 		4 GLY I 162
LEU I 163
THR I 164
ARG I 158
 None
 1.11A 1ekjF-3d1nI:
undetectable
1ekjG-3d1nI:
undetectable		 1ekjF-3d1nI:
22.22
1ekjG-3d1nI:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0s UNCHARACTERIZED
PROTEIN

(Chlorobaculum
tepidum) 		PF05235
(CHAD) 		4 LEU A 453
THR A 454
ARG A 491
VAL A 494
 None
 1.04A 1ekjF-3e0sA:
undetectable
1ekjG-3e0sA:
undetectable		 1ekjF-3e0sA:
20.54
1ekjG-3e0sA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eus DNA-BINDING PROTEIN

(Ruegeria
pomeroyi) 		PF01381
(HTH_3) 		4 GLY A  25
LEU A  26
THR A  27
ARG A  21
 None
 1.12A 1ekjF-3eusA:
undetectable
1ekjG-3eusA:
undetectable		 1ekjF-3eusA:
16.97
1ekjG-3eusA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		4 GLY A 354
LEU A  20
THR A  19
VAL A 130
 None
 1.06A 1ekjF-3g5sA:
undetectable
1ekjG-3g5sA:
undetectable		 1ekjF-3g5sA:
19.51
1ekjG-3g5sA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN

(Methanopyrus
kandleri) 		PF00383
(dCMP_cyt_deam_1)
PF02926
(THUMP) 		4 GLY A 243
LEU A 246
THR A 247
VAL A 222
 None
 0.92A 1ekjF-3g8qA:
undetectable
1ekjG-3g8qA:
undetectable		 1ekjF-3g8qA:
23.88
1ekjG-3g8qA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hck HCK SH2

(Homo sapiens) 		PF00017
(SH2) 		4 GLY A  28
LEU A  27
ARG A  47
VAL A  46
 None
 1.13A 1ekjF-3hckA:
undetectable
1ekjG-3hckA:
undetectable		 1ekjF-3hckA:
19.82
1ekjG-3hckA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hly FLAVODOXIN-LIKE
DOMAIN

(Synechococcus
elongatus) 		no annotation 4 GLY A 399
LEU A 402
THR A 403
VAL A 263
 None
 0.98A 1ekjF-3hlyA:
2.5
1ekjG-3hlyA:
2.5		 1ekjF-3hlyA:
21.43
1ekjG-3hlyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 GLY A 482
LEU A 483
THR A 465
VAL A 253
 None
 1.11A 1ekjF-3ialA:
undetectable
1ekjG-3ialA:
undetectable		 1ekjF-3ialA:
19.01
1ekjG-3ialA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivp PUTATIVE
TRANSPOSON-RELATED
DNA-BINDING PROTEIN

(Clostridioides
difficile) 		PF01381
(HTH_3) 		4 GLY A  25
LEU A  26
THR A  27
ARG A  21
 None
 1.11A 1ekjF-3ivpA:
undetectable
1ekjG-3ivpA:
undetectable		 1ekjF-3ivpA:
22.97
1ekjG-3ivpA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7e H16.V5 FAB LIGHT
CHAIN

(Mus musculus) 		no annotation 4 GLY L  70
LEU L  79
THR L  78
VAL L  54
 None
 1.09A 1ekjF-3j7eL:
undetectable
1ekjG-3j7eL:
undetectable		 1ekjF-3j7eL:
19.13
1ekjG-3j7eL:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbq PROTEIN TA0487

(Thermoplasma
acidophilum) 		PF00994
(MoCF_biosynth) 		4 GLY A  26
LEU A  29
THR A  30
VAL A   5
 None
 0.79A 1ekjF-3kbqA:
2.5
1ekjG-3kbqA:
1.3		 1ekjF-3kbqA:
21.88
1ekjG-3kbqA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l39 PUTATIVE PHOU-LIKE
PHOSPHATE REGULATORY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01865
(PhoU_div) 		4 GLY A  60
LEU A  63
THR A  64
VAL A  26
 None
 0.99A 1ekjF-3l39A:
undetectable
1ekjG-3l39A:
undetectable		 1ekjF-3l39A:
17.32
1ekjG-3l39A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Listeria
monocytogenes) 		PF00275
(EPSP_synthase) 		4 GLY A 203
LEU A 222
THR A 223
VAL A 219
 None
 0.82A 1ekjF-3r38A:
undetectable
1ekjG-3r38A:
undetectable		 1ekjF-3r38A:
19.22
1ekjG-3r38A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry0 PUTATIVE TAUTOMERASE

(Streptomyces
achromogenes) 		PF01361
(Tautomerase) 		4 GLY A  20
LEU A  23
THR A  24
VAL A  42
 None
 0.74A 1ekjF-3ry0A:
undetectable
1ekjG-3ry0A:
undetectable		 1ekjF-3ry0A:
17.02
1ekjG-3ry0A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sll PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		4 GLY A 212
LEU A 215
THR A 216
VAL A 243
 None
 0.83A 1ekjF-3sllA:
undetectable
1ekjG-3sllA:
undetectable		 1ekjF-3sllA:
20.00
1ekjG-3sllA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		4 GLY A 204
LEU A 223
THR A 224
VAL A 220
 None
None
None
GOL  A 507 (-3.9A)
 0.87A 1ekjF-3sweA:
undetectable
1ekjG-3sweA:
undetectable		 1ekjF-3sweA:
18.91
1ekjG-3sweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Roseiflexus sp.
RS-1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 241
LEU A 245
THR A 246
VAL A 234
 None
 1.11A 1ekjF-3u9iA:
undetectable
1ekjG-3u9iA:
undetectable		 1ekjF-3u9iA:
19.60
1ekjG-3u9iA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uep YSCQ-C, TYPE III
SECRETION PROTEIN

(Yersinia
pseudotuberculosis) 		PF01052
(FliMN_C) 		4 GLY A 245
LEU A 265
THR A 266
ARG A 246
 None
 1.09A 1ekjF-3uepA:
undetectable
1ekjG-3uepA:
undetectable		 1ekjF-3uepA:
19.91
1ekjG-3uepA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235

(Bacillus
licheniformis) 		PF13535
(ATP-grasp_4) 		4 GLY A 268
LEU A 211
THR A 210
VAL A 313
 None
 1.10A 1ekjF-3votA:
undetectable
1ekjG-3votA:
undetectable		 1ekjF-3votA:
19.20
1ekjG-3votA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
ALPHA

(Mammuthus
primigenius) 		PF00042
(Globin) 		4 GLY A  63
LEU A  66
THR A  67
VAL A  25
 None
 1.07A 1ekjF-3vreA:
undetectable
1ekjG-3vreA:
undetectable		 1ekjF-3vreA:
22.42
1ekjG-3vreA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN

(Streptomyces
thermoviolaceus) 		PF01547
(SBP_bac_1) 		4 GLY A 279
LEU A 188
THR A 194
VAL A 166
 None
 1.06A 1ekjF-3vxcA:
undetectable
1ekjG-3vxcA:
undetectable		 1ekjF-3vxcA:
22.82
1ekjG-3vxcA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 GLY A 589
LEU A 590
THR A 591
ARG A 595
 None
 1.07A 1ekjF-3zukA:
undetectable
1ekjG-3zukA:
undetectable		 1ekjF-3zukA:
13.93
1ekjG-3zukA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exq UROPORPHYRINOGEN
DECARBOXYLASE

(Burkholderia
thailandensis) 		PF01208
(URO-D) 		4 GLY A 152
LEU A 157
THR A 156
VAL A 195
 None
 1.00A 1ekjF-4exqA:
undetectable
1ekjG-4exqA:
undetectable		 1ekjF-4exqA:
22.93
1ekjG-4exqA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		4 GLY A 142
LEU A 145
THR A 146
VAL A 114
 None
 0.82A 1ekjF-4g2rA:
undetectable
1ekjG-4g2rA:
undetectable		 1ekjF-4g2rA:
17.72
1ekjG-4g2rA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcm THIOREDOXIN
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		4 GLY A 160
LEU A 163
THR A 164
VAL A 149
 None
 0.71A 1ekjF-4gcmA:
undetectable
1ekjG-4gcmA:
undetectable		 1ekjF-4gcmA:
20.92
1ekjG-4gcmA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		4 GLY A 257
LEU A 236
THR A 253
VAL A 123
 None
 0.96A 1ekjF-4hxqA:
undetectable
1ekjG-4hxqA:
1.8		 1ekjF-4hxqA:
21.78
1ekjG-4hxqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2o FIXK2 PROTEIN

(Bradyrhizobium
japonicum) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 GLY A 188
LEU A 191
ARG A 160
VAL A 198
 None
 1.07A 1ekjF-4i2oA:
undetectable
1ekjG-4i2oA:
undetectable		 1ekjF-4i2oA:
20.16
1ekjG-4i2oA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 GLY A  85
LEU A 346
THR A 347
VAL A 394
 GLY  A  85 ( 0.0A)
LEU  A 346 ( 0.5A)
THR  A 347 ( 0.8A)
VAL  A 394 ( 0.6A)
 1.06A 1ekjF-4kqnA:
undetectable
1ekjG-4kqnA:
undetectable		 1ekjF-4kqnA:
19.38
1ekjG-4kqnA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6n CYSTATIN-M

(Homo sapiens) 		PF00031
(Cystatin) 		4 LEU B  85
THR B  86
ARG B  45
VAL B  31
 None
 1.06A 1ekjF-4n6nB:
undetectable
1ekjG-4n6nB:
undetectable		 1ekjF-4n6nB:
22.07
1ekjG-4n6nB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		4 GLY A 215
LEU A 216
THR A 217
ARG A 243
 None
 0.79A 1ekjF-4npaA:
undetectable
1ekjG-4npaA:
undetectable		 1ekjF-4npaA:
21.43
1ekjG-4npaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LEU A  66
THR A  65
ARG A 344
VAL A 311
 None
 0.89A 1ekjF-4nsxA:
undetectable
1ekjG-4nsxA:
undetectable		 1ekjF-4nsxA:
16.46
1ekjG-4nsxA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3

(Homo sapiens) 		PF10189
(Ints3) 		4 GLY A 376
LEU A 379
THR A 380
VAL A 418
 None
 0.99A 1ekjF-4owtA:
undetectable
1ekjG-4owtA:
undetectable		 1ekjF-4owtA:
18.95
1ekjG-4owtA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgs ALCOHOL
DEHYDROGENASE YQHD

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 GLY A 270
LEU A 273
THR A 274
VAL A 288
 None
 0.94A 1ekjF-4qgsA:
2.3
1ekjG-4qgsA:
2.0		 1ekjF-4qgsA:
21.83
1ekjG-4qgsA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 GLY A 511
LEU A 514
THR A 515
VAL A 653
 None
 1.11A 1ekjF-4qiwA:
undetectable
1ekjG-4qiwA:
undetectable		 1ekjF-4qiwA:
13.60
1ekjG-4qiwA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 4 GLY A 322
LEU A 325
THR A 326
VAL A 592
 None
 0.86A 1ekjF-4qnlA:
undetectable
1ekjG-4qnlA:
undetectable		 1ekjF-4qnlA:
14.11
1ekjG-4qnlA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru4 TAIL SPIKE PROTEIN
GP49

(Pseudomonas
virus LKA1) 		PF13229
(Beta_helix) 		4 GLY A 382
LEU A 407
THR A 406
VAL A 278
 None
None
NA  A 804 ( 4.8A)
None
 0.78A 1ekjF-4ru4A:
undetectable
1ekjG-4ru4A:
undetectable		 1ekjF-4ru4A:
16.86
1ekjG-4ru4A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuo CYTOSOLIC MALATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A  16
LEU A  19
THR A  20
VAL A  85
 None
 1.04A 1ekjF-4uuoA:
2.5
1ekjG-4uuoA:
undetectable		 1ekjF-4uuoA:
22.57
1ekjG-4uuoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsh UROPORPHYRINOGEN
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF01208
(URO-D) 		4 GLY A 147
LEU A 152
THR A 151
VAL A 190
 None
 1.01A 1ekjF-4wshA:
1.5
1ekjG-4wshA:
undetectable		 1ekjF-4wshA:
20.89
1ekjG-4wshA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynv ACL4

(Chaetomium
thermophilum) 		PF13432
(TPR_16) 		4 GLY A  68
LEU A  71
THR A  72
VAL A  97
 None
 0.97A 1ekjF-4ynvA:
undetectable
1ekjG-4ynvA:
undetectable		 1ekjF-4ynvA:
21.10
1ekjG-4ynvA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr8 UROPORPHYRINOGEN
DECARBOXYLASE

(Acinetobacter
baumannii) 		PF01208
(URO-D) 		4 GLY A 146
LEU A 151
THR A 150
VAL A 189
 None
 0.90A 1ekjF-4zr8A:
undetectable
1ekjG-4zr8A:
undetectable		 1ekjF-4zr8A:
20.22
1ekjG-4zr8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbk SHHTL5

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		4 GLY A  27
LEU A 178
THR A 177
VAL A 161
 None
 0.84A 1ekjF-5cbkA:
undetectable
1ekjG-5cbkA:
undetectable		 1ekjF-5cbkA:
22.26
1ekjG-5cbkA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejh NAD KINASE 1

(Listeria
monocytogenes) 		PF01513
(NAD_kinase) 		4 GLY A 151
LEU A 152
THR A 125
VAL A 135
 None
 1.13A 1ekjF-5ejhA:
undetectable
1ekjG-5ejhA:
undetectable		 1ekjF-5ejhA:
21.36
1ekjG-5ejhA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb0 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		no annotation 4 LEU B1366
THR B1367
ARG B1391
VAL B1394
 None
 0.84A 1ekjF-5hb0B:
undetectable
1ekjG-5hb0B:
undetectable		 1ekjF-5hb0B:
17.80
1ekjG-5hb0B:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb1 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF03177
(Nucleoporin_C) 		4 LEU A1366
THR A1367
ARG A1391
VAL A1394
 None
 0.85A 1ekjF-5hb1A:
undetectable
1ekjG-5hb1A:
undetectable		 1ekjF-5hb1A:
14.25
1ekjG-5hb1A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 4 GLY B  74
LEU B  73
THR B  77
VAL B 154
 None
 1.03A 1ekjF-5hdfB:
undetectable
1ekjG-5hdfB:
undetectable		 1ekjF-5hdfB:
21.80
1ekjG-5hdfB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7v GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13320
(DUF4091) 		4 GLY A 168
LEU A  84
THR A  85
VAL A  81
 None
 0.97A 1ekjF-5l7vA:
undetectable
1ekjG-5l7vA:
undetectable		 1ekjF-5l7vA:
16.76
1ekjG-5l7vA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 GLY A 309
LEU A 243
THR A 244
VAL A 291
 None
 0.93A 1ekjF-5lhkA:
undetectable
1ekjG-5lhkA:
1.9		 1ekjF-5lhkA:
17.00
1ekjG-5lhkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 GLY A  60
LEU A  61
THR A  62
ARG A  56
 None
 1.07A 1ekjF-5lkdA:
undetectable
1ekjG-5lkdA:
undetectable		 1ekjF-5lkdA:
19.37
1ekjG-5lkdA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oup PERFORIN-LIKE
PROTEIN 1

(Toxoplasma
gondii) 		no annotation 4 GLY A 796
LEU A 797
THR A 798
VAL A 476
 None
 1.10A 1ekjF-5oupA:
undetectable
1ekjG-5oupA:
undetectable		 1ekjF-5oupA:
undetectable
1ekjG-5oupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 GLY A 178
LEU A 135
THR A 134
VAL A 196
 NAP  A 301 (-4.7A)
None
NAP  A 301 (-4.2A)
None
 1.08A 1ekjF-5t2uA:
2.9
1ekjG-5t2uA:
1.9		 1ekjF-5t2uA:
22.43
1ekjG-5t2uA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpw GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 GLY B 295
LEU B 299
THR B 300
VAL B  99
 None
 1.08A 1ekjF-5tpwB:
3.1
1ekjG-5tpwB:
3.1		 1ekjF-5tpwB:
18.46
1ekjG-5tpwB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 4 GLY B 343
LEU B 335
THR B 334
VAL B 373
 None
None
PLP  B 605 (-3.6A)
None
 1.09A 1ekjF-5txrB:
undetectable
1ekjG-5txrB:
undetectable		 1ekjF-5txrB:
undetectable
1ekjG-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 GLY A 563
LEU A 562
THR A 561
VAL A 852
 None
 1.01A 1ekjF-5um6A:
2.9
1ekjG-5um6A:
1.4		 1ekjF-5um6A:
11.83
1ekjG-5um6A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 GLY A  12
LEU A 442
ARG A 356
VAL A 355
 None
 1.07A 1ekjF-5ur2A:
2.3
1ekjG-5ur2A:
undetectable		 1ekjF-5ur2A:
12.23
1ekjG-5ur2A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wkn NUCLEOPROTEIN

(Mammalian
rubulavirus 5) 		no annotation 4 GLY A  71
LEU A  74
THR A  75
VAL A 102
 None
 1.04A 1ekjF-5wknA:
undetectable
1ekjG-5wknA:
undetectable		 1ekjF-5wknA:
undetectable
1ekjG-5wknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 4 GLY A 133
LEU A 377
THR A 376
VAL A 131
 None
 1.12A 1ekjF-5x09A:
undetectable
1ekjG-5x09A:
undetectable		 1ekjF-5x09A:
17.46
1ekjG-5x09A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus) 		no annotation 4 GLY B 436
LEU B 437
THR B 438
VAL B 504
 None
 0.98A 1ekjF-5x1yB:
undetectable
1ekjG-5x1yB:
undetectable		 1ekjF-5x1yB:
18.94
1ekjG-5x1yB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 GLY A 592
LEU A 595
THR A 596
VAL A 587
 None
 1.12A 1ekjF-5xapA:
undetectable
1ekjG-5xapA:
undetectable		 1ekjF-5xapA:
16.22
1ekjG-5xapA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ynl ARGINASE

(Glaciozyma
antarctica) 		no annotation 4 GLY A 268
LEU A 247
THR A 264
VAL A 134
 None
 0.97A 1ekjF-5ynlA:
undetectable
1ekjG-5ynlA:
undetectable		 1ekjF-5ynlA:
undetectable
1ekjG-5ynlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dcq IMMUNOGLOBULIN G
PGT151 FAB, LIGHT
CHAIN

(Homo sapiens) 		no annotation 4 GLY L  64
LEU L  73
THR L  72
VAL L  48
 None
 0.90A 1ekjF-6dcqL:
undetectable
1ekjG-6dcqL:
undetectable		 1ekjF-6dcqL:
undetectable
1ekjG-6dcqL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 4 LEU A 105
THR A 106
ARG A 129
VAL A 132
 None
 1.10A 1ekjF-6dk2A:
undetectable
1ekjG-6dk2A:
undetectable		 1ekjF-6dk2A:
undetectable
1ekjG-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 GLY A2916
LEU A2919
THR A2920
VAL A2550
 None
 0.67A 1ekjF-6ez8A:
undetectable
1ekjG-6ez8A:
undetectable		 1ekjF-6ez8A:
undetectable
1ekjG-6ez8A:
undetectable