SIMILAR PATTERNS OF AMINO ACIDS FOR 1EKJ_B_CUB4

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		4 CYH A  99
CYH A 145
PRO A 146
SER A 147
 ZN  A 999 (-2.3A)
ZN  A 999 (-2.3A)
None
ZN  A 999 ( 4.3A)
 0.93A 1ekjA-1cu1A:
1.0
1ekjB-1cu1A:
1.1		 1ekjA-1cu1A:
16.32
1ekjB-1cu1A:
16.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ekj BETA-CARBONIC
ANHYDRASE

(Pisum sativum) 		PF00484
(Pro_CA) 		4 CYH A 166
PRO A 167
SER A 168
ARG A 182
 None
 0.20A 1ekjA-1ekjA:
34.8
1ekjB-1ekjA:
31.7		 1ekjA-1ekjA:
100.00
1ekjB-1ekjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yuz NIGERYTHRIN

(Desulfovibrio
vulgaris) 		PF02915
(Rubrerythrin) 		4 CYH A 192
ARG A 194
CYH A 174
PRO A 175
 FE  A 303 (-2.2A)
None
FE  A 303 (-2.2A)
None
 1.36A 1ekjA-1yuzA:
undetectable
1ekjB-1yuzA:
undetectable		 1ekjA-1yuzA:
21.46
1ekjB-1yuzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs3 PROTEIN C14ORF4

(Homo sapiens) 		PF00097
(zf-C3HC4) 		4 CYH A  67
CYH A  33
PRO A  34
SER A  35
 ZN  A 400 (-2.3A)
ZN  A 400 (-2.3A)
None
ZN  A 400 ( 4.7A)
 0.98A 1ekjA-2cs3A:
undetectable
1ekjB-2cs3A:
undetectable		 1ekjA-2cs3A:
17.70
1ekjB-2cs3A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9w HYPOTHETICAL PROTEIN

(Psychrobacter
arcticus) 		PF02810
(SEC-C) 		4 CYH A  29
CYH A  10
PRO A   9
SER A  61
 ZN  A 200 (-2.3A)
ZN  A 200 (-2.3A)
None
ZN  A 200 ( 3.8A)
 1.39A 1ekjA-2i9wA:
0.0
1ekjB-2i9wA:
0.0		 1ekjA-2i9wA:
23.28
1ekjB-2i9wA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqj STROMAL
MEMBRANE-ASSOCIATED
PROTEIN 1-LIKE

(Homo sapiens) 		PF01412
(ArfGap) 		4 CYH A  48
CYH A  31
SER A  33
ARG A  50
 ZN  A 301 ( 2.3A)
ZN  A 301 (-2.3A)
ZN  A 301 ( 4.2A)
None
 1.50A 1ekjA-2iqjA:
undetectable
1ekjB-2iqjA:
undetectable		 1ekjA-2iqjA:
20.09
1ekjB-2iqjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 CYH A 271
CYH A 310
PRO A 269
SER A 312
 None
 1.48A 1ekjA-3cc1A:
0.0
1ekjB-3cc1A:
0.0		 1ekjA-3cc1A:
22.06
1ekjB-3cc1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcs TNF
RECEPTOR-ASSOCIATED
FACTOR 6

(Homo sapiens) 		PF13923
(zf-C3HC4_2) 		4 CYH A 165
ARG A 167
CYH A 182
PRO A 183
 ZN  A 304 (-2.4A)
None
ZN  A 304 (-2.4A)
None
 1.36A 1ekjA-3hcsA:
0.0
1ekjB-3hcsA:
0.0		 1ekjA-3hcsA:
17.94
1ekjB-3hcsA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 CYH A 363
ARG A 288
CYH A 291
PRO A 366
 None
 1.48A 1ekjA-3j4pA:
0.0
1ekjB-3j4pA:
0.0		 1ekjA-3j4pA:
18.33
1ekjB-3j4pA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knv TNF
RECEPTOR-ASSOCIATED
FACTOR 2

(Homo sapiens) 		PF00097
(zf-C3HC4) 		4 CYH A 129
CYH A 107
PRO A 108
SER A 109
 ZN  A 203 (-2.3A)
ZN  A 203 (-2.4A)
None
ZN  A 203 ( 4.1A)
 0.86A 1ekjA-3knvA:
undetectable
1ekjB-3knvA:
undetectable		 1ekjA-3knvA:
20.55
1ekjB-3knvA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 CYH A 438
CYH A 389
PRO A 442
SER A 440
 ZN  A 901 (-2.5A)
ZN  A 901 (-2.1A)
None
ZN  A 901 ( 4.0A)
 1.31A 1ekjA-5gl7A:
1.4
1ekjB-5gl7A:
1.5		 1ekjA-5gl7A:
15.85
1ekjB-5gl7A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6djw RBR-TYPE E3
UBIQUITIN
TRANSFERASE,RBR-TYPE
E3 UBIQUITIN
TRANSFERASE

(Bactrocera
dorsalis) 		no annotation 4 CYH A 324
CYH A 288
PRO A 287
SER A 331
 ZN  A1004 (-2.3A)
ZN  A1004 (-2.3A)
None
ZN  A1004 ( 4.9A)
 1.41A 1ekjA-6djwA:
0.0
1ekjB-6djwA:
0.0		 1ekjA-6djwA:
undetectable
1ekjB-6djwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6djx RBR-TYPE E3
UBIQUITIN
TRANSFERASE,RBR-TYPE
E3 UBIQUITIN
TRANSFERASE

(Bactrocera
dorsalis) 		no annotation 4 CYH A 324
CYH A 288
PRO A 287
SER A 331
 ZN  A1004 (-2.2A)
ZN  A1004 (-2.3A)
None
ZN  A1004 ( 4.9A)
 1.42A 1ekjA-6djxA:
0.0
1ekjB-6djxA:
0.0		 1ekjA-6djxA:
undetectable
1ekjB-6djxA:
undetectable