SIMILAR PATTERNS OF AMINO ACIDS FOR 1EJ0_A_SAMA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		12 ALA A  35
GLY A  59
PRO A  62
GLY A  63
GLY A  64
TRP A  65
LEU A  84
LEU A  85
PHE A 100
ARG A 101
LEU A 143
LYS A 164
 SAM  A 301 (-3.3A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.2A)
SAM  A 301 ( 4.2A)
None
SAM  A 301 (-4.7A)
SAM  A 301 (-4.6A)
SAM  A 301 ( 3.9A)
 0.14A 1ej0A-1eizA:
36.9		 1ej0A-1eizA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		6 GLY A  59
GLY A  63
PHE A 100
ARG A 101
LEU A 143
LYS A 164
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.9A)
None
SAM  A 301 (-4.7A)
SAM  A 301 (-4.6A)
SAM  A 301 ( 3.9A)
 0.93A 1ej0A-1eizA:
36.9		 1ej0A-1eizA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 ALA A 563
GLY A 567
TRP A 568
LEU A 540
LEU A 791
 None
 1.01A 1ej0A-1h7wA:
2.8		 1ej0A-1h7wA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8u EOSINOPHIL GRANULE
MAJOR BASIC PROTEIN
1

(Homo sapiens) 		PF00059
(Lectin_C) 		5 ALA A  16
GLY A  56
TRP A  53
PHE A  67
ARG A  66
 None
 0.86A 1ej0A-1h8uA:
undetectable		 1ej0A-1h8uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		5 ALA A  87
GLY A 102
GLY A  61
GLY A  83
LEU A 132
 None
 0.85A 1ej0A-1kyhA:
4.1		 1ej0A-1kyhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A 313
GLY A 182
GLY A 310
GLY A 311
PHE A  11
 None
 0.88A 1ej0A-1mzjA:
undetectable		 1ej0A-1mzjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhy ELONGATION FACTOR
1-GAMMA 1

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ALA A   8
GLY A  19
LEU A  24
LEU A  26
LEU A 163
 None
 0.93A 1ej0A-1nhyA:
undetectable		 1ej0A-1nhyA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		5 ALA A 114
GLY A 263
GLY A 257
TRP A 261
LEU A 269
 None
 0.99A 1ej0A-1o9bA:
7.7		 1ej0A-1o9bA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		6 GLY A 299
GLY A  50
GLY A  51
LEU A  74
PHE A 296
ARG A 275
 None
 1.24A 1ej0A-1oywA:
undetectable		 1ej0A-1oywA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LYS A 181
 SAH  A 887 (-3.6A)
SAH  A 887 ( 4.3A)
SAH  A 887 (-3.3A)
SAH  A 887 (-3.5A)
None
 0.61A 1ej0A-1r6aA:
13.1		 1ej0A-1r6aA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		PF00590
(TP_methylase) 		5 ALA A 214
GLY A 101
GLY A 134
GLY A 135
LEU A  98
 None
SAH  A1501 (-3.5A)
GOL  A1001 ( 4.2A)
None
None
 1.01A 1ej0A-1s4dA:
undetectable		 1ej0A-1s4dA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		5 ALA A 246
GLY A 190
GLY A 213
LEU A 126
LEU A 206
 None
FMN  A 501 (-3.8A)
None
None
None
 0.97A 1ej0A-1vcgA:
undetectable		 1ej0A-1vcgA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 GLY A  74
GLY A  67
GLY A  66
LEU A  78
LEU A  79
 None
None
NAP  A1330 (-3.5A)
None
None
 1.00A 1ej0A-1w8dA:
9.3		 1ej0A-1w8dA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 GLY A 212
GLY A 268
GLY A 267
PHE A 338
LEU A 217
 None
13P  A2002 (-2.8A)
SO4  A1003 ( 4.3A)
None
None
 1.00A 1ej0A-1wpqA:
3.4		 1ej0A-1wpqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wps HUT OPERON POSITIVE
REGULATORY PROTEIN

(Bacillus
subtilis) 		PF09021
(HutP) 		5 ALA A  82
GLY A  10
GLY A 142
LEU A  16
ARG A   7
 None
 0.97A 1ej0A-1wpsA:
undetectable		 1ej0A-1wpsA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a00 POTASSIUM-TRANSPORTI
NG ATPASE B CHAIN

(Escherichia
coli) 		no annotation 5 ALA A 407
GLY A 436
GLY A 410
GLY A 409
LEU A 440
 None
 0.94A 1ej0A-2a00A:
undetectable		 1ej0A-2a00A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		5 GLY A 405
GLY A  64
GLY A  65
LEU A 397
LEU A 363
 None
 0.99A 1ej0A-2cy8A:
2.5		 1ej0A-2cy8A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 374
GLY A 410
GLY A 426
GLY A 427
LEU A 416
 None
 0.99A 1ej0A-2e6kA:
2.5		 1ej0A-2e6kA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		6 ALA A 116
GLY A  85
GLY A 258
GLY A 259
LEU A 252
LEU A 255
 None
GOL  A2010 ( 4.5A)
None
None
None
None
 1.21A 1ej0A-2elcA:
2.1		 1ej0A-2elcA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		8 GLY A  30
PRO A  33
GLY A  34
TRP A  36
LEU A  63
LEU A  64
LEU A 123
LYS A 144
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-4.1A)
None
SAM  A 201 (-3.5A)
 0.57A 1ej0A-2nyuA:
26.3		 1ej0A-2nyuA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		6 GLY A  82
GLY A  86
GLY A  87
TRP A  88
LEU A 106
LYS A 184
 SAM  A 300 (-3.3A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 4.3A)
 0.65A 1ej0A-2oxtA:
14.7		 1ej0A-2oxtA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LYS A 182
 SAH  A 301 (-3.0A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.7A)
SAH  A 301 ( 4.9A)
 0.35A 1ej0A-2oy0A:
14.8		 1ej0A-2oy0A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfe ALKALINE SERINE
PROTEASE

(Thermobifida
fusca) 		PF00089
(Trypsin) 		5 GLY A 196
GLY A 193
GLY A 192
PHE A  45
LEU A 234
 None
None
AES  A1002 ( 3.8A)
None
None
 0.85A 1ej0A-2pfeA:
undetectable		 1ej0A-2pfeA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		7 ALA A   6
GLY A  30
PRO A  33
GLY A  34
TRP A  36
LEU A 132
LYS A 153
 SAM  A 203 (-3.5A)
SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.6A)
SAM  A 203 (-3.8A)
SAM  A 203 (-4.9A)
SAM  A 203 ( 4.1A)
 0.72A 1ej0A-2plwA:
24.8		 1ej0A-2plwA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LYS A 182
 SAH  A 500 (-3.4A)
SAH  A 500 ( 4.6A)
SAH  A 500 (-3.2A)
SAH  A 500 (-3.4A)
None
 0.67A 1ej0A-2px5A:
15.0		 1ej0A-2px5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		5 GLY A 265
PRO A 226
GLY A 225
PHE A 261
LEU A 282
 None
 0.90A 1ej0A-2q6zA:
undetectable		 1ej0A-2q6zA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		5 GLY C  26
PRO C 153
GLY C 132
LEU C 157
LEU C  56
 None
 0.97A 1ej0A-2vpwC:
undetectable		 1ej0A-2vpwC:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa2 NON-STRUCTURAL
PROTEIN 5

(Modoc virus) 		PF01728
(FtsJ) 		5 GLY A  82
GLY A  86
TRP A  88
LEU A 106
LYS A 184
 SAM  A1248 (-3.3A)
SAM  A1248 (-4.4A)
SAM  A1248 (-3.7A)
SAM  A1248 (-4.1A)
None
 0.63A 1ej0A-2wa2A:
16.3		 1ej0A-2wa2A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 157
GLY A 158
LEU A 110
LEU A 111
LEU A  45
 FAD  A 601 (-3.4A)
FAD  A 601 (-3.3A)
None
None
None
 0.89A 1ej0A-2wdwA:
undetectable		 1ej0A-2wdwA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ALA A 357
GLY A 326
GLY A 351
GLY A 353
PHE A 450
 None
 0.90A 1ej0A-2wtbA:
6.6		 1ej0A-2wtbA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		5 GLY A 235
PRO A 129
GLY A 227
LEU A 136
LEU A 133
 None
 0.98A 1ej0A-2x24A:
undetectable		 1ej0A-2x24A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		5 GLY A 372
GLY A 224
GLY A 226
LEU A 368
PHE A 348
 None
None
None
SFE  A1447 (-4.9A)
None
 0.92A 1ej0A-2ykyA:
2.7		 1ej0A-2ykyA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		5 PRO A 270
GLY A 271
GLY A 272
ARG A 320
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.5A)
None
 0.51A 1ej0A-2yxlA:
12.1		 1ej0A-2yxlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		5 ALA A 139
GLY A 190
GLY A 173
GLY A 174
ARG A 256
 None
 0.98A 1ej0A-3a1iA:
undetectable		 1ej0A-3a1iA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		5 PRO A  94
GLY A  95
GLY A  96
ARG A 144
LEU A 193
 SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
None
None
 0.42A 1ej0A-3a4tA:
11.7		 1ej0A-3a4tA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		8 ALA A  22
GLY A  46
PRO A  49
GLY A  50
GLY A  51
TRP A  52
LEU A  68
LYS A 151
 SAM  A   1 (-3.3A)
SAM  A   1 (-3.5A)
SAM  A   1 (-3.5A)
SAM  A   1 (-3.8A)
SAM  A   1 (-3.2A)
SAM  A   1 (-4.0A)
SAM  A   1 (-4.2A)
SAM  A   1 (-3.5A)
 0.33A 1ej0A-3douA:
26.8		 1ej0A-3douA:
33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LEU A 105
 SAM  A4633 (-3.2A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.5A)
SAM  A4633 (-4.1A)
 0.28A 1ej0A-3eluA:
14.7		 1ej0A-3eluA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
TRP A  87
LEU A 105
LYS A 182
 SAM  A4633 (-3.2A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.5A)
SAM  A4633 (-4.1A)
None
 0.72A 1ej0A-3eluA:
14.7		 1ej0A-3eluA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LEU A 105
 SAH  A 901 (-3.4A)
SAH  A 901 ( 4.4A)
SAH  A 901 (-3.1A)
SAH  A 901 (-3.6A)
SAH  A 901 (-4.0A)
 0.31A 1ej0A-3evcA:
15.0		 1ej0A-3evcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LEU A 105
 SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.0A)
 0.35A 1ej0A-3gczA:
15.1		 1ej0A-3gczA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
TRP A  87
LEU A 105
LYS A 183
 SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.0A)
SAM  A4633 ( 4.8A)
 0.77A 1ej0A-3gczA:
15.1		 1ej0A-3gczA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 261
GLY A 463
GLY A 462
LEU A 265
LEU A 266
 FAD  A 522 ( 4.0A)
None
None
None
None
 1.01A 1ej0A-3gdnA:
undetectable		 1ej0A-3gdnA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gei TRNA MODIFICATION
GTPASE MNME

(Chlorobaculum
tepidum) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		5 ALA A  28
GLY A 106
GLY A 101
GLY A 100
LEU A 113
 None
 0.94A 1ej0A-3geiA:
undetectable		 1ej0A-3geiA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7o GROUP 3 ALLERGEN
SMIPP-S YV6023A04

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 ALA A 198
GLY A 131
GLY A  30
GLY A 185
LEU A 143
 None
GOL  A 232 ( 4.0A)
None
None
None
 0.97A 1ej0A-3h7oA:
undetectable		 1ej0A-3h7oA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 ALA A 200
GLY A 126
GLY A  27
GLY A 187
LEU A 139
 None
 1.01A 1ej0A-3h7tA:
undetectable		 1ej0A-3h7tA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		5 ALA A 303
GLY A 247
GLY A 407
LEU A 241
LEU A 293
 None
 1.01A 1ej0A-3hvyA:
undetectable		 1ej0A-3hvyA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		5 ALA A  18
GLY A 331
GLY A  13
GLY A  16
ARG A  54
 None
FAD  A 371 (-3.1A)
FAD  A 371 (-3.2A)
None
None
 0.99A 1ej0A-3if9A:
undetectable		 1ej0A-3if9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 GLY A 137
GLY A 168
LEU A 112
LEU A  70
LYS A 145
 None
 0.96A 1ej0A-3ju1A:
undetectable		 1ej0A-3ju1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kci PROBABLE E3
UBIQUITIN-PROTEIN
LIGASE HERC2

(Homo sapiens) 		PF00415
(RCC1) 		5 GLY A3956
GLY A3966
GLY A3967
LEU A3990
LEU A4298
 None
 1.01A 1ej0A-3kciA:
undetectable		 1ej0A-3kciA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3li9 HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE

(Methanosarcina
mazei) 		PF02743
(dCache_1) 		5 ALA A 255
GLY A 264
GLY A 265
PHE A  58
LEU A 230
 None
 0.99A 1ej0A-3li9A:
undetectable		 1ej0A-3li9A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLY A  86
TRP A  87
ARG A 163
LYS A 182
 SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
None
SFG  A 301 ( 4.1A)
 1.16A 1ej0A-3lkzA:
15.3		 1ej0A-3lkzA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 6 ALA A 504
GLY A 104
GLY A 264
GLY A 507
PHE A 229
ARG A 228
 None
FAD  A 601 (-3.1A)
FAD  A 601 (-3.2A)
None
None
None
 1.27A 1ej0A-3nlcA:
undetectable		 1ej0A-3nlcA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pty ARABINOSYLTRANSFERAS
E C

(Mycobacterium
tuberculosis) 		PF14896
(Arabino_trans_C) 		5 ALA A 771
GLY A 780
LEU A 898
LEU A 945
LEU A 871
 None
 0.98A 1ej0A-3ptyA:
undetectable		 1ej0A-3ptyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		5 ALA A 194
GLY A 158
GLY A 197
GLY A 196
LEU A 353
 None
 0.96A 1ej0A-3qfwA:
undetectable		 1ej0A-3qfwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 262
GLY A 464
GLY A 463
LEU A 266
LEU A 267
 FAD  A 773 ( 4.0A)
None
None
FAD  A 773 ( 4.6A)
None
 0.98A 1ej0A-3redA:
2.4		 1ej0A-3redA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 ALA A 115
GLY A  24
GLY A  54
GLY A  53
LEU A  29
 None
 0.88A 1ej0A-3rreA:
4.4		 1ej0A-3rreA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 ALA A 256
GLY A 184
GLY A 275
GLY A 276
LEU A 218
 None
 0.82A 1ej0A-3tbhA:
3.0		 1ej0A-3tbhA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		5 ALA A 633
GLY A 622
GLY A 642
GLY A 641
LEU A 665
 None
 0.93A 1ej0A-3txaA:
undetectable		 1ej0A-3txaA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		6 ALA A 152
GLY A 146
GLY A 148
LEU A 102
LEU A 104
LEU A 138
 None
 1.10A 1ej0A-3v9aA:
2.6		 1ej0A-3v9aA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A1319
GLY A1479
GLY A1347
GLY A1348
LEU A1484
 None
None
BTI  A1901 (-3.1A)
BTI  A1901 (-4.3A)
None
 0.94A 1ej0A-3va7A:
3.3		 1ej0A-3va7A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		5 ALA A  30
GLY A  80
GLY A 111
GLY A  26
LEU A 116
 None
None
SO4  A 402 (-3.3A)
SO4  A 402 (-3.3A)
None
 0.85A 1ej0A-3vzbA:
undetectable		 1ej0A-3vzbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE

(Xenopus laevis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 371
GLY A 292
GLY A 288
GLY A 287
LEU A 299
 None
 0.79A 1ej0A-3w0lA:
undetectable		 1ej0A-3w0lA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 GLY A 106
PRO A 117
GLY A 115
GLY A 114
LEU A 134
 GDP  A1368 (-3.6A)
None
None
None
None
 1.00A 1ej0A-4b46A:
undetectable		 1ej0A-4b46A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3y 3-KETOSTEROID
DEHYDROGENASE

(Rhodococcus
erythropolis) 		PF00890
(FAD_binding_2) 		5 ALA A 497
GLY A  16
GLY A  17
LEU A 195
LEU A 472
 FAD  A 551 ( 4.5A)
FAD  A 551 (-3.4A)
None
FAD  A 551 (-4.6A)
None
 0.91A 1ej0A-4c3yA:
3.0		 1ej0A-4c3yA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 GLY A  61
GLY A  55
GLY A  54
TRP A  57
LEU A 438
ARG A 416
 None
 1.45A 1ej0A-4d5gA:
2.5		 1ej0A-4d5gA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		6 PRO A 185
GLY A 185
GLY A 186
LEU A 205
ARG A 239
LEU A 291
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.8A)
None
None
 0.89A 1ej0A-4fzvA:
9.0		 1ej0A-4fzvA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 ALA A 100
GLY A 354
GLY A 146
GLY A 147
LEU A 800
 None
 0.77A 1ej0A-4iugA:
undetectable		 1ej0A-4iugA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 108
GLY A 236
LEU A 167
LEU A 170
LEU A 114
 None
 0.81A 1ej0A-4jatA:
undetectable		 1ej0A-4jatA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyl ENOYL-COA HYDRATASE

(Thermoplasma
volcanium) 		PF00378
(ECH_1) 		5 ALA A 111
GLY A 140
GLY A 105
GLY A 107
LEU A 156
 None
None
CL  A 301 (-3.6A)
None
None
 0.96A 1ej0A-4jylA:
undetectable		 1ej0A-4jylA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  85
GLY A  86
TRP A  87
ARG A 160
LEU A 184
 SAH  A1001 (-4.3A)
SAH  A1001 (-3.2A)
SAH  A1001 (-3.9A)
None
None
 1.00A 1ej0A-4k6mA:
14.8		 1ej0A-4k6mA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 ALA A  46
GLY A  75
GLY A  79
LEU A  97
LEU A 100
 SAM  A 301 (-3.2A)
SAM  A 301 (-3.5A)
None
SAM  A 301 (-4.4A)
SAM  A 301 ( 4.8A)
 0.78A 1ej0A-4lg1A:
10.4		 1ej0A-4lg1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 ALA A  95
GLY A 120
PRO A 123
GLY A 124
LEU A 142
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
None
UNX  A1016 ( 2.9A)
SAH  A1001 (-4.2A)
 0.57A 1ej0A-4mtlA:
11.6		 1ej0A-4mtlA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		7 ALA A 236
PRO A 280
GLY A 281
GLY A 282
LEU A 302
LEU A 383
LYS A 404
 SAM  A 601 (-3.2A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.6A)
SAM  A 601 ( 4.1A)
 0.58A 1ej0A-4n49A:
17.9		 1ej0A-4n49A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqi SH3
DOMAIN-CONTAINING
PROTEIN

(Dictyostelium
discoideum) 		PF08397
(IMD) 		5 GLY A  72
GLY A  66
GLY A  67
LEU A  58
LEU A  61
 None
 0.96A 1ej0A-4nqiA:
undetectable		 1ej0A-4nqiA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Deinococcus
radiodurans) 		PF02540
(NAD_synthase) 		5 ALA A 102
GLY A  53
GLY A  64
LEU A 155
LEU A  84
 None
 0.96A 1ej0A-4q16A:
undetectable		 1ej0A-4q16A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q48 DNA HELICASE RECQ

(Deinococcus
radiodurans) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		6 ALA A  42
GLY A  39
GLY A  40
LEU A  61
LEU A  62
LEU A 117
 None
 1.13A 1ej0A-4q48A:
undetectable		 1ej0A-4q48A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		5 ALA A  80
GLY A  73
GLY A 298
GLY A 299
LEU A  96
 None
None
None
None
SAH  A1000 (-4.0A)
 1.00A 1ej0A-4qppA:
7.2		 1ej0A-4qppA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY

(Alcanivorax
borkumensis) 		PF03806
(ABG_transport) 		5 ALA A 172
GLY A 168
GLY A 169
LEU A 474
LEU A 473
 None
 1.00A 1ej0A-4r0cA:
undetectable		 1ej0A-4r0cA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqo L-SERINE DEHYDRATASE

(Legionella
pneumophila) 		PF03313
(SDH_alpha)
PF03315
(SDH_beta) 		5 GLY A  52
GLY A 449
GLY A 450
LEU A 116
LEU A 121
 None
 0.81A 1ej0A-4rqoA:
undetectable		 1ej0A-4rqoA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 ALA A 224
GLY A 407
GLY A 421
GLY A 420
LEU A 729
 None
 0.89A 1ej0A-4umvA:
3.1		 1ej0A-4umvA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca) 		PF07993
(NAD_binding_4) 		5 ALA A1318
GLY A1243
GLY A1262
LEU A1153
LEU A1160
 None
 0.87A 1ej0A-4w4tA:
5.7		 1ej0A-4w4tA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrw BEXL

(Amycolatopsis
orientalis) 		PF10604
(Polyketide_cyc2) 		5 ALA A 113
PRO A 118
GLY A 119
GLY A 120
LYS A   1
 None
 0.99A 1ej0A-4xrwA:
undetectable		 1ej0A-4xrwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqz PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 ALA A 116
GLY A 119
GLY A 118
LEU A   9
LEU A  72
 None
 0.99A 1ej0A-4yqzA:
10.1		 1ej0A-4yqzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A 382
GLY A  99
GLY A 219
LEU A  53
LEU A 104
 None
 1.01A 1ej0A-4zyjA:
undetectable		 1ej0A-4zyjA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		6 ALA A1484
GLY A1478
GLY A1473
LEU A1567
LEU A1564
LEU A1656
 None
 1.45A 1ej0A-5a31A:
undetectable		 1ej0A-5a31A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 GLY A 169
PRO A  86
GLY A  87
GLY A  88
LEU A 597
 None
 0.98A 1ej0A-5dmyA:
undetectable		 1ej0A-5dmyA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 ALA A 522
GLY A 243
TRP A 242
LEU A 205
LEU A 259
 None
 0.83A 1ej0A-5ficA:
undetectable		 1ej0A-5ficA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fus PUTATIVE ENOYL COA
HYDRATASE

(Burkholderia
cenocepacia) 		PF00378
(ECH_1) 		5 ALA A 140
GLY A 169
GLY A 134
GLY A 136
LEU A 185
 None
 0.94A 1ej0A-5fusA:
undetectable		 1ej0A-5fusA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 ALA A 522
GLY A 243
TRP A 242
LEU A 205
LEU A 259
 None
 0.81A 1ej0A-5hqnA:
undetectable		 1ej0A-5hqnA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		5 ALA A 524
GLY A 245
TRP A 244
LEU A 207
LEU A 261
 None
 0.88A 1ej0A-5i85A:
2.2		 1ej0A-5i85A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A1319
GLY A1479
GLY A1347
GLY A1348
LEU A1484
 None
 0.93A 1ej0A-5i8iA:
4.1		 1ej0A-5i8iA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig8 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 5 ALA A 282
GLY A 301
GLY A 302
LEU A 172
LEU A 135
 None
 0.90A 1ej0A-5ig8A:
undetectable		 1ej0A-5ig8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LYS A 180
 SAH  A1003 (-3.4A)
SAH  A1003 ( 4.6A)
SAH  A1003 (-3.0A)
SAH  A1003 (-3.4A)
None
 0.69A 1ej0A-5jjrA:
12.8		 1ej0A-5jjrA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		6 ALA A1484
GLY A1478
GLY A1473
LEU A1567
LEU A1564
LEU A1656
 None
 1.47A 1ej0A-5lcwA:
undetectable		 1ej0A-5lcwA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtf RHOMBOID PROTEASE
GLPG

(Escherichia
coli) 		no annotation 5 ALA A  93
GLY A 162
GLY A 163
LEU A 200
PHE A 153
 CL  A 302 ( 3.6A)
None
BNG  A 306 (-3.4A)
None
None
 0.99A 1ej0A-5mtfA:
undetectable		 1ej0A-5mtfA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		5 GLY J 278
GLY J 583
GLY J 584
LEU J 274
LEU J 273
 None
 0.92A 1ej0A-5nilJ:
undetectable		 1ej0A-5nilJ:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 6 GLY A  81
GLY A  85
GLY A  86
TRP A  87
ARG A 163
LYS A 182
 SAH  A1001 (-3.4A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.5A)
None
None
 1.26A 1ej0A-5njuA:
14.6		 1ej0A-5njuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  85
GLY A  86
TRP A  87
ARG A 160
LEU A 184
 SAH  A1001 ( 4.9A)
SAH  A1001 (-3.6A)
SAH  A1001 (-3.5A)
GOL  A1005 (-4.1A)
None
 1.00A 1ej0A-5tmhA:
16.6		 1ej0A-5tmhA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 5 ALA A  84
GLY A 169
GLY A 299
GLY A 300
LEU A  62
 None
None
None
42Y  A 118 ( 3.2A)
None
 0.99A 1ej0A-5wgcA:
undetectable		 1ej0A-5wgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
PERMEAE

(Streptococcus
pneumoniae) 		no annotation 5 GLY M  24
GLY M 350
GLY M 351
LEU M  20
LEU M  19
 None
 0.85A 1ej0A-5xu1M:
undetectable		 1ej0A-5xu1M:
undetectable