SIMILAR PATTERNS OF AMINO ACIDS FOR 1EJ0_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		12 ALA A  35
GLY A  59
PRO A  62
GLY A  63
GLY A  64
TRP A  65
LEU A  84
LEU A  85
PHE A 100
ARG A 101
LEU A 143
LYS A 164
 SAM  A 301 (-3.3A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.2A)
SAM  A 301 ( 4.2A)
None
SAM  A 301 (-4.7A)
SAM  A 301 (-4.6A)
SAM  A 301 ( 3.9A)
 0.14A 1ej0A-1eizA:
36.9		 1ej0A-1eizA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		6 GLY A  59
GLY A  63
PHE A 100
ARG A 101
LEU A 143
LYS A 164
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.9A)
None
SAM  A 301 (-4.7A)
SAM  A 301 (-4.6A)
SAM  A 301 ( 3.9A)
 0.93A 1ej0A-1eizA:
36.9		 1ej0A-1eizA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 ALA A 563
GLY A 567
TRP A 568
LEU A 540
LEU A 791
 None
 1.01A 1ej0A-1h7wA:
2.8		 1ej0A-1h7wA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8u EOSINOPHIL GRANULE
MAJOR BASIC PROTEIN
1

(Homo sapiens) 		PF00059
(Lectin_C) 		5 ALA A  16
GLY A  56
TRP A  53
PHE A  67
ARG A  66
 None
 0.86A 1ej0A-1h8uA:
undetectable		 1ej0A-1h8uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		5 ALA A  87
GLY A 102
GLY A  61
GLY A  83
LEU A 132
 None
 0.85A 1ej0A-1kyhA:
4.1		 1ej0A-1kyhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A 313
GLY A 182
GLY A 310
GLY A 311
PHE A  11
 None
 0.88A 1ej0A-1mzjA:
undetectable		 1ej0A-1mzjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhy ELONGATION FACTOR
1-GAMMA 1

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ALA A   8
GLY A  19
LEU A  24
LEU A  26
LEU A 163
 None
 0.93A 1ej0A-1nhyA:
undetectable		 1ej0A-1nhyA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		5 ALA A 114
GLY A 263
GLY A 257
TRP A 261
LEU A 269
 None
 0.99A 1ej0A-1o9bA:
7.7		 1ej0A-1o9bA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		6 GLY A 299
GLY A  50
GLY A  51
LEU A  74
PHE A 296
ARG A 275
 None
 1.24A 1ej0A-1oywA:
undetectable		 1ej0A-1oywA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LYS A 181
 SAH  A 887 (-3.6A)
SAH  A 887 ( 4.3A)
SAH  A 887 (-3.3A)
SAH  A 887 (-3.5A)
None
 0.61A 1ej0A-1r6aA:
13.1		 1ej0A-1r6aA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		PF00590
(TP_methylase) 		5 ALA A 214
GLY A 101
GLY A 134
GLY A 135
LEU A  98
 None
SAH  A1501 (-3.5A)
GOL  A1001 ( 4.2A)
None
None
 1.01A 1ej0A-1s4dA:
undetectable		 1ej0A-1s4dA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		5 ALA A 246
GLY A 190
GLY A 213
LEU A 126
LEU A 206
 None
FMN  A 501 (-3.8A)
None
None
None
 0.97A 1ej0A-1vcgA:
undetectable		 1ej0A-1vcgA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 GLY A  74
GLY A  67
GLY A  66
LEU A  78
LEU A  79
 None
None
NAP  A1330 (-3.5A)
None
None
 1.00A 1ej0A-1w8dA:
9.3		 1ej0A-1w8dA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 GLY A 212
GLY A 268
GLY A 267
PHE A 338
LEU A 217
 None
13P  A2002 (-2.8A)
SO4  A1003 ( 4.3A)
None
None
 1.00A 1ej0A-1wpqA:
3.4		 1ej0A-1wpqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wps HUT OPERON POSITIVE
REGULATORY PROTEIN

(Bacillus
subtilis) 		PF09021
(HutP) 		5 ALA A  82
GLY A  10
GLY A 142
LEU A  16
ARG A   7
 None
 0.97A 1ej0A-1wpsA:
undetectable		 1ej0A-1wpsA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a00 POTASSIUM-TRANSPORTI
NG ATPASE B CHAIN

(Escherichia
coli) 		no annotation 5 ALA A 407
GLY A 436
GLY A 410
GLY A 409
LEU A 440
 None
 0.94A 1ej0A-2a00A:
undetectable		 1ej0A-2a00A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		5 GLY A 405
GLY A  64
GLY A  65
LEU A 397
LEU A 363
 None
 0.99A 1ej0A-2cy8A:
2.5		 1ej0A-2cy8A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 374
GLY A 410
GLY A 426
GLY A 427
LEU A 416
 None
 0.99A 1ej0A-2e6kA:
2.5		 1ej0A-2e6kA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		6 ALA A 116
GLY A  85
GLY A 258
GLY A 259
LEU A 252
LEU A 255
 None
GOL  A2010 ( 4.5A)
None
None
None
None
 1.21A 1ej0A-2elcA:
2.1		 1ej0A-2elcA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		8 GLY A  30
PRO A  33
GLY A  34
TRP A  36
LEU A  63
LEU A  64
LEU A 123
LYS A 144
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-4.1A)
None
SAM  A 201 (-3.5A)
 0.57A 1ej0A-2nyuA:
26.3		 1ej0A-2nyuA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		6 GLY A  82
GLY A  86
GLY A  87
TRP A  88
LEU A 106
LYS A 184
 SAM  A 300 (-3.3A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 4.3A)
 0.65A 1ej0A-2oxtA:
14.7		 1ej0A-2oxtA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LYS A 182
 SAH  A 301 (-3.0A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.7A)
SAH  A 301 ( 4.9A)
 0.35A 1ej0A-2oy0A:
14.8		 1ej0A-2oy0A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfe ALKALINE SERINE
PROTEASE

(Thermobifida
fusca) 		PF00089
(Trypsin) 		5 GLY A 196
GLY A 193
GLY A 192
PHE A  45
LEU A 234
 None
None
AES  A1002 ( 3.8A)
None
None
 0.85A 1ej0A-2pfeA:
undetectable		 1ej0A-2pfeA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		7 ALA A   6
GLY A  30
PRO A  33
GLY A  34
TRP A  36
LEU A 132
LYS A 153
 SAM  A 203 (-3.5A)
SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.6A)
SAM  A 203 (-3.8A)
SAM  A 203 (-4.9A)
SAM  A 203 ( 4.1A)
 0.72A 1ej0A-2plwA:
24.8		 1ej0A-2plwA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LYS A 182
 SAH  A 500 (-3.4A)
SAH  A 500 ( 4.6A)
SAH  A 500 (-3.2A)
SAH  A 500 (-3.4A)
None
 0.67A 1ej0A-2px5A:
15.0		 1ej0A-2px5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		5 GLY A 265
PRO A 226
GLY A 225
PHE A 261
LEU A 282
 None
 0.90A 1ej0A-2q6zA:
undetectable		 1ej0A-2q6zA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		5 GLY C  26
PRO C 153
GLY C 132
LEU C 157
LEU C  56
 None
 0.97A 1ej0A-2vpwC:
undetectable		 1ej0A-2vpwC:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa2 NON-STRUCTURAL
PROTEIN 5

(Modoc virus) 		PF01728
(FtsJ) 		5 GLY A  82
GLY A  86
TRP A  88
LEU A 106
LYS A 184
 SAM  A1248 (-3.3A)
SAM  A1248 (-4.4A)
SAM  A1248 (-3.7A)
SAM  A1248 (-4.1A)
None
 0.63A 1ej0A-2wa2A:
16.3		 1ej0A-2wa2A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 157
GLY A 158
LEU A 110
LEU A 111
LEU A  45
 FAD  A 601 (-3.4A)
FAD  A 601 (-3.3A)
None
None
None
 0.89A 1ej0A-2wdwA:
undetectable		 1ej0A-2wdwA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ALA A 357
GLY A 326
GLY A 351
GLY A 353
PHE A 450
 None
 0.90A 1ej0A-2wtbA:
6.6		 1ej0A-2wtbA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		5 GLY A 235
PRO A 129
GLY A 227
LEU A 136
LEU A 133
 None
 0.98A 1ej0A-2x24A:
undetectable		 1ej0A-2x24A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		5 GLY A 372
GLY A 224
GLY A 226
LEU A 368
PHE A 348
 None
None
None
SFE  A1447 (-4.9A)
None
 0.92A 1ej0A-2ykyA:
2.7		 1ej0A-2ykyA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		5 PRO A 270
GLY A 271
GLY A 272
ARG A 320
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.5A)
None
 0.51A 1ej0A-2yxlA:
12.1		 1ej0A-2yxlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		5 ALA A 139
GLY A 190
GLY A 173
GLY A 174
ARG A 256
 None
 0.98A 1ej0A-3a1iA:
undetectable		 1ej0A-3a1iA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		5 PRO A  94
GLY A  95
GLY A  96
ARG A 144
LEU A 193
 SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
None
None
 0.42A 1ej0A-3a4tA:
11.7		 1ej0A-3a4tA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		8 ALA A  22
GLY A  46
PRO A  49
GLY A  50
GLY A  51
TRP A  52
LEU A  68
LYS A 151
 SAM  A   1 (-3.3A)
SAM  A   1 (-3.5A)
SAM  A   1 (-3.5A)
SAM  A   1 (-3.8A)
SAM  A   1 (-3.2A)
SAM  A   1 (-4.0A)
SAM  A   1 (-4.2A)
SAM  A   1 (-3.5A)
 0.33A 1ej0A-3douA:
26.8		 1ej0A-3douA:
33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LEU A 105
 SAM  A4633 (-3.2A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.5A)
SAM  A4633 (-4.1A)
 0.28A 1ej0A-3eluA:
14.7		 1ej0A-3eluA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
TRP A  87
LEU A 105
LYS A 182
 SAM  A4633 (-3.2A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.5A)
SAM  A4633 (-4.1A)
None
 0.72A 1ej0A-3eluA:
14.7		 1ej0A-3eluA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LEU A 105
 SAH  A 901 (-3.4A)
SAH  A 901 ( 4.4A)
SAH  A 901 (-3.1A)
SAH  A 901 (-3.6A)
SAH  A 901 (-4.0A)
 0.31A 1ej0A-3evcA:
15.0		 1ej0A-3evcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LEU A 105
 SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.0A)
 0.35A 1ej0A-3gczA:
15.1		 1ej0A-3gczA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
TRP A  87
LEU A 105
LYS A 183
 SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.0A)
SAM  A4633 ( 4.8A)
 0.77A 1ej0A-3gczA:
15.1		 1ej0A-3gczA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 261
GLY A 463
GLY A 462
LEU A 265
LEU A 266
 FAD  A 522 ( 4.0A)
None
None
None
None
 1.01A 1ej0A-3gdnA:
undetectable		 1ej0A-3gdnA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gei TRNA MODIFICATION
GTPASE MNME

(Chlorobaculum
tepidum) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		5 ALA A  28
GLY A 106
GLY A 101
GLY A 100
LEU A 113
 None
 0.94A 1ej0A-3geiA:
undetectable		 1ej0A-3geiA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7o GROUP 3 ALLERGEN
SMIPP-S YV6023A04

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 ALA A 198
GLY A 131
GLY A  30
GLY A 185
LEU A 143
 None
GOL  A 232 ( 4.0A)
None
None
None
 0.97A 1ej0A-3h7oA:
undetectable		 1ej0A-3h7oA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 ALA A 200
GLY A 126
GLY A  27
GLY A 187
LEU A 139
 None
 1.01A 1ej0A-3h7tA:
undetectable		 1ej0A-3h7tA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		5 ALA A 303
GLY A 247
GLY A 407
LEU A 241
LEU A 293
 None
 1.01A 1ej0A-3hvyA:
undetectable		 1ej0A-3hvyA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		5 ALA A  18
GLY A 331
GLY A  13
GLY A  16
ARG A  54
 None
FAD  A 371 (-3.1A)
FAD  A 371 (-3.2A)
None
None
 0.99A 1ej0A-3if9A:
undetectable		 1ej0A-3if9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 GLY A 137
GLY A 168
LEU A 112
LEU A  70
LYS A 145
 None
 0.96A 1ej0A-3ju1A:
undetectable		 1ej0A-3ju1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kci PROBABLE E3
UBIQUITIN-PROTEIN
LIGASE HERC2

(Homo sapiens) 		PF00415
(RCC1) 		5 GLY A3956
GLY A3966
GLY A3967
LEU A3990
LEU A4298
 None
 1.01A 1ej0A-3kciA:
undetectable		 1ej0A-3kciA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3li9 HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE

(Methanosarcina
mazei) 		PF02743
(dCache_1) 		5 ALA A 255
GLY A 264
GLY A 265
PHE A  58
LEU A 230
 None
 0.99A 1ej0A-3li9A:
undetectable		 1ej0A-3li9A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLY A  86
TRP A  87
ARG A 163
LYS A 182
 SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
None
SFG  A 301 ( 4.1A)
 1.16A 1ej0A-3lkzA:
15.3		 1ej0A-3lkzA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 6 ALA A 504
GLY A 104
GLY A 264
GLY A 507
PHE A 229
ARG A 228
 None
FAD  A 601 (-3.1A)
FAD  A 601 (-3.2A)
None
None
None
 1.27A 1ej0A-3nlcA:
undetectable		 1ej0A-3nlcA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pty ARABINOSYLTRANSFERAS
E C

(Mycobacterium
tuberculosis) 		PF14896
(Arabino_trans_C) 		5 ALA A 771
GLY A 780
LEU A 898
LEU A 945
LEU A 871
 None
 0.98A 1ej0A-3ptyA:
undetectable		 1ej0A-3ptyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		5 ALA A 194
GLY A 158
GLY A 197
GLY A 196
LEU A 353
 None
 0.96A 1ej0A-3qfwA:
undetectable		 1ej0A-3qfwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 262
GLY A 464
GLY A 463
LEU A 266
LEU A 267
 FAD  A 773 ( 4.0A)
None
None
FAD  A 773 ( 4.6A)
None
 0.98A 1ej0A-3redA:
2.4		 1ej0A-3redA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 ALA A 115
GLY A  24
GLY A  54
GLY A  53
LEU A  29
 None
 0.88A 1ej0A-3rreA:
4.4		 1ej0A-3rreA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 ALA A 256
GLY A 184
GLY A 275
GLY A 276
LEU A 218
 None
 0.82A 1ej0A-3tbhA:
3.0		 1ej0A-3tbhA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		5 ALA A 633
GLY A 622
GLY A 642
GLY A 641
LEU A 665
 None
 0.93A 1ej0A-3txaA:
undetectable		 1ej0A-3txaA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		6 ALA A 152
GLY A 146
GLY A 148
LEU A 102
LEU A 104
LEU A 138
 None
 1.10A 1ej0A-3v9aA:
2.6		 1ej0A-3v9aA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A1319
GLY A1479
GLY A1347
GLY A1348
LEU A1484
 None
None
BTI  A1901 (-3.1A)
BTI  A1901 (-4.3A)
None
 0.94A 1ej0A-3va7A:
3.3		 1ej0A-3va7A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		5 ALA A  30
GLY A  80
GLY A 111
GLY A  26
LEU A 116
 None
None
SO4  A 402 (-3.3A)
SO4  A 402 (-3.3A)
None
 0.85A 1ej0A-3vzbA:
undetectable		 1ej0A-3vzbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE

(Xenopus laevis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 371
GLY A 292
GLY A 288
GLY A 287
LEU A 299
 None
 0.79A 1ej0A-3w0lA:
undetectable		 1ej0A-3w0lA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 GLY A 106
PRO A 117
GLY A 115
GLY A 114
LEU A 134
 GDP  A1368 (-3.6A)
None
None
None
None
 1.00A 1ej0A-4b46A:
undetectable		 1ej0A-4b46A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3y 3-KETOSTEROID
DEHYDROGENASE

(Rhodococcus
erythropolis) 		PF00890
(FAD_binding_2) 		5 ALA A 497
GLY A  16
GLY A  17
LEU A 195
LEU A 472
 FAD  A 551 ( 4.5A)
FAD  A 551 (-3.4A)
None
FAD  A 551 (-4.6A)
None
 0.91A 1ej0A-4c3yA:
3.0		 1ej0A-4c3yA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 GLY A  61
GLY A  55
GLY A  54
TRP A  57
LEU A 438
ARG A 416
 None
 1.45A 1ej0A-4d5gA:
2.5		 1ej0A-4d5gA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		6 PRO A 185
GLY A 185
GLY A 186
LEU A 205
ARG A 239
LEU A 291
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.8A)
None
None
 0.89A 1ej0A-4fzvA:
9.0		 1ej0A-4fzvA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 ALA A 100
GLY A 354
GLY A 146
GLY A 147
LEU A 800
 None
 0.77A 1ej0A-4iugA:
undetectable		 1ej0A-4iugA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 108
GLY A 236
LEU A 167
LEU A 170
LEU A 114
 None
 0.81A 1ej0A-4jatA:
undetectable		 1ej0A-4jatA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyl ENOYL-COA HYDRATASE

(Thermoplasma
volcanium) 		PF00378
(ECH_1) 		5 ALA A 111
GLY A 140
GLY A 105
GLY A 107
LEU A 156
 None
None
CL  A 301 (-3.6A)
None
None
 0.96A 1ej0A-4jylA:
undetectable		 1ej0A-4jylA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  85
GLY A  86
TRP A  87
ARG A 160
LEU A 184
 SAH  A1001 (-4.3A)
SAH  A1001 (-3.2A)
SAH  A1001 (-3.9A)
None
None
 1.00A 1ej0A-4k6mA:
14.8		 1ej0A-4k6mA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 ALA A  46
GLY A  75
GLY A  79
LEU A  97
LEU A 100
 SAM  A 301 (-3.2A)
SAM  A 301 (-3.5A)
None
SAM  A 301 (-4.4A)
SAM  A 301 ( 4.8A)
 0.78A 1ej0A-4lg1A:
10.4		 1ej0A-4lg1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 ALA A  95
GLY A 120
PRO A 123
GLY A 124
LEU A 142
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
None
UNX  A1016 ( 2.9A)
SAH  A1001 (-4.2A)
 0.57A 1ej0A-4mtlA:
11.6		 1ej0A-4mtlA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		7 ALA A 236
PRO A 280
GLY A 281
GLY A 282
LEU A 302
LEU A 383
LYS A 404
 SAM  A 601 (-3.2A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.6A)
SAM  A 601 ( 4.1A)
 0.58A 1ej0A-4n49A:
17.9		 1ej0A-4n49A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqi SH3
DOMAIN-CONTAINING
PROTEIN

(Dictyostelium
discoideum) 		PF08397
(IMD) 		5 GLY A  72
GLY A  66
GLY A  67
LEU A  58
LEU A  61
 None
 0.96A 1ej0A-4nqiA:
undetectable		 1ej0A-4nqiA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Deinococcus
radiodurans) 		PF02540
(NAD_synthase) 		5 ALA A 102
GLY A  53
GLY A  64
LEU A 155
LEU A  84
 None
 0.96A 1ej0A-4q16A:
undetectable		 1ej0A-4q16A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q48 DNA HELICASE RECQ

(Deinococcus
radiodurans) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		6 ALA A  42
GLY A  39
GLY A  40
LEU A  61
LEU A  62
LEU A 117
 None
 1.13A 1ej0A-4q48A:
undetectable		 1ej0A-4q48A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		5 ALA A  80
GLY A  73
GLY A 298
GLY A 299
LEU A  96
 None
None
None
None
SAH  A1000 (-4.0A)
 1.00A 1ej0A-4qppA:
7.2		 1ej0A-4qppA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY

(Alcanivorax
borkumensis) 		PF03806
(ABG_transport) 		5 ALA A 172
GLY A 168
GLY A 169
LEU A 474
LEU A 473
 None
 1.00A 1ej0A-4r0cA:
undetectable		 1ej0A-4r0cA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqo L-SERINE DEHYDRATASE

(Legionella
pneumophila) 		PF03313
(SDH_alpha)
PF03315
(SDH_beta) 		5 GLY A  52
GLY A 449
GLY A 450
LEU A 116
LEU A 121
 None
 0.81A 1ej0A-4rqoA:
undetectable		 1ej0A-4rqoA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 ALA A 224
GLY A 407
GLY A 421
GLY A 420
LEU A 729
 None
 0.89A 1ej0A-4umvA:
3.1		 1ej0A-4umvA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca) 		PF07993
(NAD_binding_4) 		5 ALA A1318
GLY A1243
GLY A1262
LEU A1153
LEU A1160
 None
 0.87A 1ej0A-4w4tA:
5.7		 1ej0A-4w4tA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrw BEXL

(Amycolatopsis
orientalis) 		PF10604
(Polyketide_cyc2) 		5 ALA A 113
PRO A 118
GLY A 119
GLY A 120
LYS A   1
 None
 0.99A 1ej0A-4xrwA:
undetectable		 1ej0A-4xrwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqz PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 ALA A 116
GLY A 119
GLY A 118
LEU A   9
LEU A  72
 None
 0.99A 1ej0A-4yqzA:
10.1		 1ej0A-4yqzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A 382
GLY A  99
GLY A 219
LEU A  53
LEU A 104
 None
 1.01A 1ej0A-4zyjA:
undetectable		 1ej0A-4zyjA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		6 ALA A1484
GLY A1478
GLY A1473
LEU A1567
LEU A1564
LEU A1656
 None
 1.45A 1ej0A-5a31A:
undetectable		 1ej0A-5a31A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 GLY A 169
PRO A  86
GLY A  87
GLY A  88
LEU A 597
 None
 0.98A 1ej0A-5dmyA:
undetectable		 1ej0A-5dmyA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 ALA A 522
GLY A 243
TRP A 242
LEU A 205
LEU A 259
 None
 0.83A 1ej0A-5ficA:
undetectable		 1ej0A-5ficA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fus PUTATIVE ENOYL COA
HYDRATASE

(Burkholderia
cenocepacia) 		PF00378
(ECH_1) 		5 ALA A 140
GLY A 169
GLY A 134
GLY A 136
LEU A 185
 None
 0.94A 1ej0A-5fusA:
undetectable		 1ej0A-5fusA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 ALA A 522
GLY A 243
TRP A 242
LEU A 205
LEU A 259
 None
 0.81A 1ej0A-5hqnA:
undetectable		 1ej0A-5hqnA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		5 ALA A 524
GLY A 245
TRP A 244
LEU A 207
LEU A 261
 None
 0.88A 1ej0A-5i85A:
2.2		 1ej0A-5i85A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A1319
GLY A1479
GLY A1347
GLY A1348
LEU A1484
 None
 0.93A 1ej0A-5i8iA:
4.1		 1ej0A-5i8iA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig8 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 5 ALA A 282
GLY A 301
GLY A 302
LEU A 172
LEU A 135
 None
 0.90A 1ej0A-5ig8A:
undetectable		 1ej0A-5ig8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LYS A 180
 SAH  A1003 (-3.4A)
SAH  A1003 ( 4.6A)
SAH  A1003 (-3.0A)
SAH  A1003 (-3.4A)
None
 0.69A 1ej0A-5jjrA:
12.8		 1ej0A-5jjrA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		6 ALA A1484
GLY A1478
GLY A1473
LEU A1567
LEU A1564
LEU A1656
 None
 1.47A 1ej0A-5lcwA:
undetectable		 1ej0A-5lcwA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtf RHOMBOID PROTEASE
GLPG

(Escherichia
coli) 		no annotation 5 ALA A  93
GLY A 162
GLY A 163
LEU A 200
PHE A 153
 CL  A 302 ( 3.6A)
None
BNG  A 306 (-3.4A)
None
None
 0.99A 1ej0A-5mtfA:
undetectable		 1ej0A-5mtfA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		5 GLY J 278
GLY J 583
GLY J 584
LEU J 274
LEU J 273
 None
 0.92A 1ej0A-5nilJ:
undetectable		 1ej0A-5nilJ:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 6 GLY A  81
GLY A  85
GLY A  86
TRP A  87
ARG A 163
LYS A 182
 SAH  A1001 (-3.4A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.5A)
None
None
 1.26A 1ej0A-5njuA:
14.6		 1ej0A-5njuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  85
GLY A  86
TRP A  87
ARG A 160
LEU A 184
 SAH  A1001 ( 4.9A)
SAH  A1001 (-3.6A)
SAH  A1001 (-3.5A)
GOL  A1005 (-4.1A)
None
 1.00A 1ej0A-5tmhA:
16.6		 1ej0A-5tmhA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 5 ALA A  84
GLY A 169
GLY A 299
GLY A 300
LEU A  62
 None
None
None
42Y  A 118 ( 3.2A)
None
 0.99A 1ej0A-5wgcA:
undetectable		 1ej0A-5wgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
PERMEAE

(Streptococcus
pneumoniae) 		no annotation 5 GLY M  24
GLY M 350
GLY M 351
LEU M  20
LEU M  19
 None
 0.85A 1ej0A-5xu1M:
undetectable		 1ej0A-5xu1M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		3 ASP A 396
ASP A 302
ASP A 360
 None
 0.68A 1ej0A-1amyA:
undetectable		 1ej0A-1amyA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 ASP A 128
ASP A 121
ASP A 133
 None
None
K  A4019 ( 4.6A)
 0.77A 1ej0A-1c30A:
4.7		 1ej0A-1c30A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckm MRNA CAPPING ENZYME

(Paramecium
bursaria
Chlorella virus
1) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		3 ASP A  45
ASP A  49
ASP A  38
 None
 0.64A 1ej0A-1ckmA:
undetectable		 1ej0A-1ckmA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		3 ASP A 670
ASP A 687
ASP A 665
 None
 0.76A 1ej0A-1d0nA:
undetectable		 1ej0A-1d0nA:
14.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		3 ASP A  83
ASP A  99
ASP A 124
 SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
 0.08A 1ej0A-1eizA:
36.9		 1ej0A-1eizA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanopyrus
kandleri) 		PF00296
(Bac_luciferase) 		3 ASP A 303
ASP A 239
ASP A 309
 None
 0.65A 1ej0A-1ezwA:
undetectable		 1ej0A-1ezwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioo SF11-RNASE

(Nicotiana alata) 		PF00445
(Ribonuclease_T2) 		3 ASP A 113
ASP A 116
ASP A  62
 NAG  A 198 ( 3.5A)
NAG  A 197 (-3.7A)
XYP  A 200 ( 4.6A)
 0.69A 1ej0A-1iooA:
undetectable		 1ej0A-1iooA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxi PHOSPHOMETHYLPYRIMID
INE KINASE

(Salmonella
enterica) 		PF08543
(Phos_pyr_kin) 		3 ASP A  58
ASP A  65
ASP A  85
 None
 0.76A 1ej0A-1jxiA:
3.4		 1ej0A-1jxiA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9x M32 CARBOXYPEPTIDASE

(Pyrococcus
furiosus) 		PF02074
(Peptidase_M32) 		3 ASP A 171
ASP A 161
ASP A 484
 None
 0.72A 1ej0A-1k9xA:
undetectable		 1ej0A-1k9xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lss TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKA
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF02254
(TrkA_N) 		3 ASP A  30
ASP A  34
ASP A  51
 NAD  A1001 (-2.9A)
None
NAD  A1001 (-3.3A)
 0.66A 1ej0A-1lssA:
8.5		 1ej0A-1lssA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi8 DNAB INTEIN

(Synechocystis
sp. PCC 6803) 		PF14890
(Intein_splicing) 		3 ASP A  21
ASP A  24
ASP A   5
 None
 0.71A 1ej0A-1mi8A:
undetectable		 1ej0A-1mi8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne2 HYPOTHETICAL PROTEIN
TA1320

(Thermoplasma
acidophilum) 		PF06325
(PrmA) 		3 ASP A  78
ASP A  82
ASP A 100
 None
 0.69A 1ej0A-1ne2A:
13.1		 1ej0A-1ne2A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI

(Rhodobacter
sphaeroides) 		PF01555
(N6_N4_Mtase) 		3 ASP A 271
ASP A  46
ASP A  65
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.3A)
 0.59A 1ej0A-1nw5A:
3.1		 1ej0A-1nw5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		3 ASP A  45
ASP A 169
ASP A 160
 None
 0.77A 1ej0A-1p5sA:
undetectable		 1ej0A-1p5sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp0 VOLVATOXIN A2

(Volvariella
volvacea) 		PF01338
(Bac_thur_toxin) 		3 ASP A  64
ASP A  61
ASP A  88
 None
 0.77A 1ej0A-1pp0A:
undetectable		 1ej0A-1pp0A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		3 ASP A 510
ASP A 543
ASP A 482
 None
MN  A 885 (-3.0A)
None
 0.79A 1ej0A-1qb4A:
undetectable		 1ej0A-1qb4A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6j CALCIUM-DEPENDENT
PROTEIN KINASE SK5

(Glycine max) 		PF13499
(EF-hand_7) 		3 ASP A  33
ASP A  47
ASP A  77
 CA  A  88 (-3.0A)
None
CA  A  89 (-4.3A)
 0.79A 1ej0A-1s6jA:
undetectable		 1ej0A-1s6jA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 ASP A 120
ASP A 251
ASP A 144
 None
 0.67A 1ej0A-1taqA:
undetectable		 1ej0A-1taqA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		3 ASP A  67
ASP A  71
ASP A  93
 SAM  A 302 (-2.8A)
None
SAM  A 302 (-3.4A)
 0.68A 1ej0A-1ve3A:
11.6		 1ej0A-1ve3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl5 UNKNOWN CONSERVED
PROTEIN BH2331

(Bacillus
halodurans) 		PF08241
(Methyltransf_11) 		3 ASP A  71
ASP A  75
ASP A  98
 None
 0.78A 1ej0A-1vl5A:
13.0		 1ej0A-1vl5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wk1 HYPOTHETICAL PROTEIN
YK1067A12

(Caenorhabditis
elegans) 		PF00059
(Lectin_C) 		3 ASP A 117
ASP A  95
ASP A 104
 None
 0.68A 1ej0A-1wk1A:
undetectable		 1ej0A-1wk1A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASP A 509
ASP A 323
ASP A 501
 None
 0.65A 1ej0A-1xkhA:
undetectable		 1ej0A-1xkhA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yo6 PUTATIVE CARBONYL
REDUCTASE SNIFFER

(Caenorhabditis
elegans) 		PF00106
(adh_short) 		3 ASP A 192
ASP A 138
ASP A 189
 None
 0.60A 1ej0A-1yo6A:
9.6		 1ej0A-1yo6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 ASP A 172
ASP A 220
ASP A 278
 None
 0.65A 1ej0A-1yr2A:
2.5		 1ej0A-1yr2A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1

(Medicago
truncatula) 		PF00201
(UDPGT) 		3 ASP A 166
ASP A 168
ASP A 190
 None
 0.79A 1ej0A-2acvA:
3.8		 1ej0A-2acvA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 258
ASP A 285
ASP A 305
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 (-3.7A)
 0.65A 1ej0A-2b9eA:
13.2		 1ej0A-2b9eA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		3 ASP A  78
ASP A  82
ASP A 120
 None
 0.69A 1ej0A-2dulA:
9.7		 1ej0A-2dulA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kma TALIN 1

(Mus musculus) 		PF09379
(FERM_N)
PF16511
(FERM_f0) 		3 ASP A  77
ASP A  69
ASP A  53
 None
 0.66A 1ej0A-2kmaA:
undetectable		 1ej0A-2kmaA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		3 ASP A  62
ASP A  79
ASP A 104
 SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
 0.42A 1ej0A-2nyuA:
26.3		 1ej0A-2nyuA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oka HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF10262
(Rdx) 		3 ASP A  83
ASP A  35
ASP A  87
 None
 0.75A 1ej0A-2okaA:
undetectable		 1ej0A-2okaA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		3 ASP A 195
ASP A 202
ASP A 249
 None
 0.62A 1ej0A-2pg8A:
undetectable		 1ej0A-2pg8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvs CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT

(Mus musculus) 		PF00027
(cNMP_binding) 		3 ASP B 181
ASP B 197
ASP B 159
 ASP  B 181 ( 0.5A)
ASP  B 197 ( 0.6A)
ASP  B 159 ( 0.5A)
 0.70A 1ej0A-2qvsB:
undetectable		 1ej0A-2qvsB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrn PROTEASE I

(Deinococcus
radiodurans) 		PF01965
(DJ-1_PfpI) 		3 ASP A  77
ASP A 184
ASP A  75
 None
 0.77A 1ej0A-2vrnA:
2.7		 1ej0A-2vrnA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmr PROTEIN NDRG2

(Homo sapiens) 		PF03096
(Ndr) 		3 ASP A 158
ASP A 228
ASP A 255
 None
 0.61A 1ej0A-2xmrA:
2.5		 1ej0A-2xmrA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		3 ASP A  99
ASP A 114
ASP A 130
 SAH  A1293 (-2.7A)
SAH  A1293 (-3.7A)
SAH  A1293 (-3.7A)
 0.36A 1ej0A-2xyqA:
14.8		 1ej0A-2xyqA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		3 ASP A  86
ASP A  93
ASP A 110
 None
 0.68A 1ej0A-2yv2A:
7.1		 1ej0A-2yv2A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		3 ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.63A 1ej0A-2yxlA:
12.1		 1ej0A-2yxlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 3 ASP A  76
ASP A 139
ASP A  81
 None
 0.72A 1ej0A-3a0fA:
undetectable		 1ej0A-3a0fA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6v KINESIN-LIKE PROTEIN
KIF3C

(Homo sapiens) 		PF00225
(Kinesin) 		3 ASP A  65
ASP A  36
ASP A  72
 UNX  A1003 (-4.8A)
None
None
 0.62A 1ej0A-3b6vA:
undetectable		 1ej0A-3b6vA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		3 ASP A 404
ASP A 385
ASP A 447
 None
 0.69A 1ej0A-3bz5A:
undetectable		 1ej0A-3bz5A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3y O-METHYLTRANSFERASE

(Mesembryanthemum
crystallinum) 		PF01596
(Methyltransf_3) 		3 ASP A 102
ASP A 130
ASP A 154
 SAH  A 464 (-2.8A)
SAH  A 464 (-4.1A)
CA  A 238 ( 2.2A)
 0.65A 1ej0A-3c3yA:
14.4		 1ej0A-3c3yA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		3 ASP A 108
ASP A  72
ASP A 136
 None
 0.78A 1ej0A-3c9fA:
undetectable		 1ej0A-3c9fA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF13489
(Methyltransf_23) 		3 ASP A 311
ASP A 315
ASP A 330
 None
 0.74A 1ej0A-3dliA:
12.4		 1ej0A-3dliA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		3 ASP A  67
ASP A  83
ASP A 111
 SAM  A   1 (-2.7A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.7A)
 0.20A 1ej0A-3douA:
26.8		 1ej0A-3douA:
33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghg FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 ASP C 294
ASP C 298
ASP C 291
 ASP  C 294 ( 0.5A)
ASP  C 298 ( 0.6A)
ASP  C 291 ( 0.6A)
 0.74A 1ej0A-3ghgC:
undetectable		 1ej0A-3ghgC:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm7 ALLANTOINASE

(Bacillus
halodurans) 		PF01979
(Amidohydro_1) 		3 ASP A 437
ASP A 405
ASP A 394
 None
 0.60A 1ej0A-3hm7A:
undetectable		 1ej0A-3hm7A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT

(Mus musculus) 		PF00027
(cNMP_binding)
PF02197
(RIIa) 		3 ASP B 183
ASP B 199
ASP B 161
 None
 0.71A 1ej0A-3j4rB:
undetectable		 1ej0A-3j4rB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		3 ASP A 415
ASP A 543
ASP A 571
 None
 0.78A 1ej0A-3j9dA:
undetectable		 1ej0A-3j9dA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l39 PUTATIVE PHOU-LIKE
PHOSPHATE REGULATORY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01865
(PhoU_div) 		3 ASP A  93
ASP A  61
ASP A  86
 None
 0.73A 1ej0A-3l39A:
undetectable		 1ej0A-3l39A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		3 ASP A  79
ASP A  69
ASP A  41
 None
CA  A 342 ( 2.5A)
None
 0.79A 1ej0A-3lpdA:
undetectable		 1ej0A-3lpdA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		3 ASP A 166
ASP A  59
ASP A 172
 PGE  A 698 (-4.3A)
None
None
 0.75A 1ej0A-3lvvA:
undetectable		 1ej0A-3lvvA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 3 ASP A 177
ASP A 196
ASP A 139
 None
None
MG  A 324 ( 2.9A)
 0.57A 1ej0A-3p4gA:
undetectable		 1ej0A-3p4gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		3 ASP A 331
ASP A 334
ASP A 429
 None
 0.67A 1ej0A-3qanA:
3.7		 1ej0A-3qanA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r24 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		3 ASP A  99
ASP A 114
ASP A 130
 SAM  A 302 (-2.6A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
 0.41A 1ej0A-3r24A:
14.8		 1ej0A-3r24A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slg PBGP3 PROTEIN

(Burkholderia
pseudomallei) 		PF01370
(Epimerase) 		3 ASP A  35
ASP A  39
ASP A  56
 None
 0.77A 1ej0A-3slgA:
6.4		 1ej0A-3slgA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 3 ASP A 234
ASP A 252
ASP A 275
 SAH  A 601 (-2.8A)
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 0.76A 1ej0A-3ssmA:
13.1		 1ej0A-3ssmA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdu DCN1-LIKE PROTEIN 1

(Homo sapiens) 		PF03556
(Cullin_binding) 		3 ASP A  91
ASP A  96
ASP A  84
 None
 0.65A 1ej0A-3tduA:
undetectable		 1ej0A-3tduA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		3 ASP A 107
ASP A 166
ASP A 189
 SAH  A 258 (-2.7A)
SAH  A 258 (-3.4A)
SAH  A 258 ( 3.6A)
 0.46A 1ej0A-3tosA:
10.7		 1ej0A-3tosA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A

(Saccharomyces
cerevisiae) 		PF16787
(NDC10_II) 		3 ASP A 312
ASP A 320
ASP A 456
 None
 0.74A 1ej0A-4acoA:
undetectable		 1ej0A-4acoA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		3 ASP A 401
ASP A 318
ASP A 378
 None
 0.78A 1ej0A-4dykA:
undetectable		 1ej0A-4dykA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 ASP A 296
ASP A 258
ASP A 334
 None
 0.78A 1ej0A-4ewtA:
undetectable		 1ej0A-4ewtA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 204
ASP A 237
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.61A 1ej0A-4fzvA:
9.0		 1ej0A-4fzvA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gao DCN1-LIKE PROTEIN 2

(Homo sapiens) 		PF03556
(Cullin_binding) 		3 ASP A  91
ASP A  96
ASP A  84
 None
 0.59A 1ej0A-4gaoA:
undetectable		 1ej0A-4gaoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		3 ASP A 259
ASP A  20
ASP A 135
 None
 0.77A 1ej0A-4gpgA:
undetectable		 1ej0A-4gpgA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz4 GLUTATHIONE-S-TRANSF
ERASE

(Actinobacillus
pleuropneumoniae) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASP A  60
ASP A  77
ASP A  62
 None
 0.75A 1ej0A-4hz4A:
undetectable		 1ej0A-4hz4A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ife GENE 2 PROTEIN

(Shigella virus
Sf6) 		PF04466
(Terminase_3)
PF17288
(Terminase_3C) 		3 ASP A 244
ASP A 251
ASP A 298
 None
 0.73A 1ej0A-4ifeA:
3.7		 1ej0A-4ifeA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		3 ASP A 431
ASP A 311
ASP A 385
 MMA  A 502 (-3.1A)
None
None
 0.68A 1ej0A-4mq0A:
undetectable		 1ej0A-4mq0A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1

(Streptomyces
avermitilis) 		PF00698
(Acyl_transf_1) 		3 ASP A  89
ASP A  86
ASP A  69
 None
 0.77A 1ej0A-4rl1A:
undetectable		 1ej0A-4rl1A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wiw GLYCOSIDE HYDROLASE
FAMILY 18

(Desulfitobacterium
hafniense) 		PF00704
(Glyco_hydro_18) 		3 ASP A 464
ASP A 478
ASP A 467
 None
 0.69A 1ej0A-4wiwA:
undetectable		 1ej0A-4wiwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 ASP A 427
ASP A 432
ASP A 420
 None
 0.62A 1ej0A-4xmvA:
undetectable		 1ej0A-4xmvA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 ASP A 118
ASP A 149
ASP A 168
 S4M  A 301 (-3.0A)
S4M  A 301 (-3.9A)
S4M  A 301 (-3.1A)
 0.79A 1ej0A-4yv2A:
11.4		 1ej0A-4yv2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		3 ASP A 669
ASP A 695
ASP A 666
 ASP  A 669 ( 0.5A)
ASP  A 695 ( 0.6A)
ASP  A 666 ( 0.6A)
 0.67A 1ej0A-4zkeA:
undetectable		 1ej0A-4zkeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zte CADHERIN-1

(Homo sapiens) 		PF00028
(Cadherin) 		3 ASP A 100
ASP A  67
ASP A 138
 CA  A 402 (-3.0A)
CA  A 403 (-3.0A)
None
 0.66A 1ej0A-4zteA:
undetectable		 1ej0A-4zteA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		3 ASP A  43
ASP A 252
ASP A  30
 EDO  A1562 (-2.9A)
None
None
 0.70A 1ej0A-5a4jA:
2.2		 1ej0A-5a4jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		3 ASP A  43
ASP A 251
ASP A  30
 None
 0.69A 1ej0A-5a5gA:
undetectable		 1ej0A-5a5gA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		3 ASP A 585
ASP A 590
ASP A 582
 None
 0.62A 1ej0A-5by3A:
undetectable		 1ej0A-5by3A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
BETA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		PF02239
(Cytochrom_D1) 		3 ASP B 337
ASP B 281
ASP B 333
 None
 0.74A 1ej0A-5c2vB:
undetectable		 1ej0A-5c2vB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co1 PROTOCADHERIN-19
ISOFORM 1

(Danio rerio) 		PF00028
(Cadherin) 		3 ASP A 236
ASP A 216
ASP A 269
 CA  A1004 (-3.1A)
None
None
 0.71A 1ej0A-5co1A:
undetectable		 1ej0A-5co1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 ASP A 436
ASP A 441
ASP A 429
 None
CL  A 915 ( 4.7A)
None
 0.73A 1ej0A-5dllA:
undetectable		 1ej0A-5dllA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek5 IRMA

(Escherichia
coli) 		no annotation 3 ASP A  78
ASP A  17
ASP A  33
 None
 0.51A 1ej0A-5ek5A:
undetectable		 1ej0A-5ek5A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 ASP A  55
ASP A 177
ASP A  16
 None
 0.78A 1ej0A-5f7cA:
undetectable		 1ej0A-5f7cA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7o METHYLTHIOADENOSINE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		3 ASP A  95
ASP A 202
ASP A 164
 None
 0.65A 1ej0A-5f7oA:
undetectable		 1ej0A-5f7oA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		3 ASP A 391
ASP A  55
ASP A 404
 None
 0.56A 1ej0A-5jlcA:
undetectable		 1ej0A-5jlcA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		3 ASP A 305
ASP A 302
ASP A 274
 None
 0.74A 1ej0A-5jp9A:
undetectable		 1ej0A-5jp9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 ASP A 286
ASP A 282
ASP A 217
 GOL  A 602 ( 4.8A)
None
None
 0.74A 1ej0A-5kgnA:
2.4		 1ej0A-5kgnA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 ASP A 129
ASP A 122
ASP A 340
 None
 0.59A 1ej0A-5lkdA:
undetectable		 1ej0A-5lkdA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5log PUTATIVE
O-METHYLTRANSFERASE

(Myxococcus
xanthus) 		PF01596
(Methyltransf_3) 		3 ASP A  91
ASP A 119
ASP A 142
 SAH  A1001 (-2.8A)
SAH  A1001 (-3.8A)
MG  A1002 (-2.5A)
 0.67A 1ej0A-5logA:
14.1		 1ej0A-5logA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m58 C-METHYLTRANSFERASE
COUO

(Streptomyces
rishiriensis) 		PF13649
(Methyltransf_25) 		3 ASP A  70
ASP A  74
ASP A  96
 SAH  A 301 (-2.8A)
None
SAH  A 301 (-3.5A)
 0.73A 1ej0A-5m58A:
12.1		 1ej0A-5m58A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 ASP A 383
ASP A 378
ASP A 560
 None
 0.78A 1ej0A-5m6uA:
undetectable		 1ej0A-5m6uA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE

(Streptomyces
niveus) 		PF13649
(Methyltransf_25) 		3 ASP A  70
ASP A  74
ASP A  96
 SAH  A 301 (-2.8A)
None
SAH  A 301 (-3.5A)
 0.71A 1ej0A-5mgzA:
10.4		 1ej0A-5mgzA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v88 LYSOZYME,DCN1-LIKE
PROTEIN 1

(Homo sapiens;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF03556
(Cullin_binding) 		3 ASP A1091
ASP A1096
ASP A1084
 None
 0.60A 1ej0A-5v88A:
undetectable		 1ej0A-5v88A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 3 ASP A 664
ASP A 657
ASP A 683
 None
 0.78A 1ej0A-5whsA:
undetectable		 1ej0A-5whsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 266
ASP A 293
ASP A 323
 None
None
C  C  72 ( 2.8A)
 0.63A 1ej0A-5wwtA:
10.6		 1ej0A-5wwtA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3e KINESIN-LIKE PROTEIN

(Caenorhabditis
elegans) 		PF00225
(Kinesin) 		3 ASP A 223
ASP A 249
ASP A 227
 None
None
SO4  A 519 (-4.4A)
 0.76A 1ej0A-5x3eA:
undetectable		 1ej0A-5x3eA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8h SHORT-CHAIN
DEHYDROGENASE
REDUCTASE

(Chryseobacterium
sp. CA49) 		no annotation 3 ASP A  37
ASP A  41
ASP A  63
 None
 0.72A 1ej0A-5x8hA:
9.9		 1ej0A-5x8hA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xne -

(-) 		no annotation 3 ASP B  33
ASP B 239
ASP B 232
 None
 0.71A 1ej0A-5xneB:
undetectable		 1ej0A-5xneB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygu DIAMINOPIMELATE
EPIMERASE

(Escherichia
coli) 		no annotation 3 ASP A  57
ASP A  53
ASP A  94
 None
 0.65A 1ej0A-5yguA:
undetectable		 1ej0A-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 ASP A 567
ASP A 572
ASP A 653
 None
 0.62A 1ej0A-5zqzA:
5.7		 1ej0A-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE

(Acetobacterium
woodii) 		no annotation 3 ASP A 277
ASP A 355
ASP A 275
 None
 0.68A 1ej0A-6fahA:
2.1		 1ej0A-6fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 3 ASP E 312
ASP E 320
ASP E 456
 None
 0.74A 1ej0A-6gsaE:
undetectable		 1ej0A-6gsaE:
undetectable