SIMILAR PATTERNS OF AMINO ACIDS FOR 1EIZ_A_SAMA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		12 ALA A  35
GLY A  59
PRO A  62
GLY A  63
GLY A  64
TRP A  65
LEU A  84
LEU A  85
PHE A 100
ARG A 101
LEU A 143
LYS A 164
 SAM  A 301 (-3.3A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.2A)
SAM  A 301 ( 4.2A)
None
SAM  A 301 (-4.7A)
SAM  A 301 (-4.6A)
SAM  A 301 ( 3.9A)
 0.00A 1eizA-1eizA:
38.6		 1eizA-1eizA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8u EOSINOPHIL GRANULE
MAJOR BASIC PROTEIN
1

(Homo sapiens) 		PF00059
(Lectin_C) 		5 ALA A  16
GLY A  56
TRP A  53
PHE A  67
ARG A  66
 None
 0.93A 1eizA-1h8uA:
undetectable		 1eizA-1h8uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		5 ALA A  87
GLY A 102
GLY A  61
GLY A  83
LEU A 132
 None
 0.83A 1eizA-1kyhA:
4.2		 1eizA-1kyhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		6 ALA A 313
GLY A 182
GLY A 310
GLY A 311
LEU A  15
PHE A  11
 None
 1.23A 1eizA-1mzjA:
undetectable		 1eizA-1mzjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhy ELONGATION FACTOR
1-GAMMA 1

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ALA A   8
GLY A  19
LEU A  24
LEU A  26
LEU A 163
 None
 0.96A 1eizA-1nhyA:
undetectable		 1eizA-1nhyA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT

(Klebsiella
pneumoniae) 		PF03830
(PTSIIB_sorb) 		5 GLY A 106
GLY A 107
LEU A 155
LEU A 141
LYS A 114
 None
 1.00A 1eizA-1nrzA:
undetectable		 1eizA-1nrzA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		5 ALA A 114
GLY A 263
GLY A 257
TRP A 261
LEU A 269
 None
 0.99A 1eizA-1o9bA:
7.7		 1eizA-1o9bA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		6 GLY A 299
GLY A  50
GLY A  51
LEU A  74
PHE A 296
ARG A 275
 None
 1.25A 1eizA-1oywA:
2.5		 1eizA-1oywA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLY A  86
TRP A  87
ARG A 163
LYS A 181
 SAH  A 887 (-3.6A)
SAH  A 887 ( 4.3A)
SAH  A 887 (-3.3A)
SAH  A 887 (-3.5A)
None
None
 1.32A 1eizA-1r6aA:
14.7		 1eizA-1r6aA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9k RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE C

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		5 ALA A 112
GLY A 116
GLY A 115
LEU A 200
ARG A 208
 None
 0.87A 1eizA-1v9kA:
undetectable		 1eizA-1v9kA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		5 ALA A 246
GLY A 190
GLY A 213
LEU A 126
LEU A 206
 None
FMN  A 501 (-3.8A)
None
None
None
 0.97A 1eizA-1vcgA:
undetectable		 1eizA-1vcgA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN

(Thermus
thermophilus) 		PF06778
(Chlor_dismutase) 		5 GLY A  14
GLY A  82
LEU A  79
ARG A 131
LEU A 114
 None
 0.93A 1eizA-1vdhA:
undetectable		 1eizA-1vdhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 GLY A  74
GLY A  67
GLY A  66
LEU A  78
LEU A  79
 None
None
NAP  A1330 (-3.5A)
None
None
 1.00A 1eizA-1w8dA:
9.4		 1eizA-1w8dA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a00 POTASSIUM-TRANSPORTI
NG ATPASE B CHAIN

(Escherichia
coli) 		no annotation 5 ALA A 407
GLY A 436
GLY A 410
GLY A 409
LEU A 440
 None
 0.96A 1eizA-2a00A:
undetectable		 1eizA-2a00A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		5 GLY A 405
GLY A  64
GLY A  65
LEU A 397
LEU A 363
 None
 1.00A 1eizA-2cy8A:
undetectable		 1eizA-2cy8A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 374
GLY A 410
GLY A 426
GLY A 427
LEU A 416
 None
 1.00A 1eizA-2e6kA:
2.4		 1eizA-2e6kA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		6 ALA A 116
GLY A  85
GLY A 258
GLY A 259
LEU A 252
LEU A 255
 None
GOL  A2010 ( 4.5A)
None
None
None
None
 1.23A 1eizA-2elcA:
2.2		 1eizA-2elcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 GLY A 149
GLY A 145
GLY A 144
LEU A 207
LEU A 132
 None
 0.83A 1eizA-2fncA:
undetectable		 1eizA-2fncA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 GLY A 149
GLY A 145
GLY A 144
LEU A 207
LEU A 132
 None
 0.86A 1eizA-2ghbA:
undetectable		 1eizA-2ghbA:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		8 GLY A  30
PRO A  33
GLY A  34
TRP A  36
LEU A  63
LEU A  64
LEU A 123
LYS A 144
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-4.1A)
None
SAM  A 201 (-3.5A)
 0.57A 1eizA-2nyuA:
26.6		 1eizA-2nyuA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		6 GLY A  82
GLY A  86
GLY A  87
TRP A  88
LEU A 106
LYS A 184
 SAM  A 300 (-3.3A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 4.3A)
 0.62A 1eizA-2oxtA:
14.9		 1eizA-2oxtA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LYS A 182
 SAH  A 301 (-3.0A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.7A)
SAH  A 301 ( 4.9A)
 0.33A 1eizA-2oy0A:
14.9		 1eizA-2oy0A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfe ALKALINE SERINE
PROTEASE

(Thermobifida
fusca) 		PF00089
(Trypsin) 		5 GLY A 196
GLY A 193
GLY A 192
PHE A  45
LEU A 234
 None
None
AES  A1002 ( 3.8A)
None
None
 0.87A 1eizA-2pfeA:
undetectable		 1eizA-2pfeA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		7 ALA A   6
GLY A  30
PRO A  33
GLY A  34
TRP A  36
LEU A 132
LYS A 153
 SAM  A 203 (-3.5A)
SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.6A)
SAM  A 203 (-3.8A)
SAM  A 203 (-4.9A)
SAM  A 203 ( 4.1A)
 0.75A 1eizA-2plwA:
24.7		 1eizA-2plwA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLY A  86
TRP A  87
ARG A 163
LYS A 182
 SAH  A 500 (-3.4A)
SAH  A 500 ( 4.6A)
SAH  A 500 (-3.2A)
SAH  A 500 (-3.4A)
None
None
 1.30A 1eizA-2px5A:
15.1		 1eizA-2px5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		5 GLY A 265
PRO A 226
GLY A 225
PHE A 261
LEU A 282
 None
 0.90A 1eizA-2q6zA:
undetectable		 1eizA-2q6zA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		5 GLY C  26
PRO C 153
GLY C 132
LEU C 157
LEU C  56
 None
 0.97A 1eizA-2vpwC:
undetectable		 1eizA-2vpwC:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa2 NON-STRUCTURAL
PROTEIN 5

(Modoc virus) 		PF01728
(FtsJ) 		5 GLY A  82
GLY A  86
TRP A  88
LEU A 106
LYS A 184
 SAM  A1248 (-3.3A)
SAM  A1248 (-4.4A)
SAM  A1248 (-3.7A)
SAM  A1248 (-4.1A)
None
 0.59A 1eizA-2wa2A:
16.5		 1eizA-2wa2A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 157
GLY A 158
LEU A 110
LEU A 111
LEU A  45
 FAD  A 601 (-3.4A)
FAD  A 601 (-3.3A)
None
None
None
 0.90A 1eizA-2wdwA:
undetectable		 1eizA-2wdwA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ALA A 357
GLY A 326
GLY A 351
GLY A 353
PHE A 450
 None
 0.90A 1eizA-2wtbA:
6.6		 1eizA-2wtbA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		5 GLY A 235
PRO A 129
GLY A 227
LEU A 136
LEU A 133
 None
 0.99A 1eizA-2x24A:
2.0		 1eizA-2x24A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		5 GLY A 372
GLY A 224
GLY A 226
LEU A 368
PHE A 348
 None
None
None
SFE  A1447 (-4.9A)
None
 0.94A 1eizA-2ykyA:
2.5		 1eizA-2ykyA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		5 PRO A 270
GLY A 271
GLY A 272
ARG A 320
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.5A)
None
 0.55A 1eizA-2yxlA:
12.0		 1eizA-2yxlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		5 ALA A 139
GLY A 190
GLY A 173
GLY A 174
ARG A 256
 None
 0.99A 1eizA-3a1iA:
undetectable		 1eizA-3a1iA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		5 PRO A  94
GLY A  95
GLY A  96
ARG A 144
LEU A 193
 SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
None
None
 0.46A 1eizA-3a4tA:
14.2		 1eizA-3a4tA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		8 ALA A  22
GLY A  46
PRO A  49
GLY A  50
GLY A  51
TRP A  52
LEU A  68
LYS A 151
 SAM  A   1 (-3.3A)
SAM  A   1 (-3.5A)
SAM  A   1 (-3.5A)
SAM  A   1 (-3.8A)
SAM  A   1 (-3.2A)
SAM  A   1 (-4.0A)
SAM  A   1 (-4.2A)
SAM  A   1 (-3.5A)
 0.33A 1eizA-3douA:
26.9		 1eizA-3douA:
33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LEU A 105
LYS A 182
 SAM  A4633 (-3.2A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.5A)
SAM  A4633 (-4.1A)
None
 0.63A 1eizA-3eluA:
14.8		 1eizA-3eluA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLY A  86
TRP A  87
ARG A 163
LYS A 182
 SAH  A 901 (-3.4A)
SAH  A 901 ( 4.4A)
SAH  A 901 (-3.1A)
SAH  A 901 (-3.6A)
None
None
 1.22A 1eizA-3evcA:
15.1		 1eizA-3evcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LEU A 105
LYS A 182
 SAH  A 901 (-3.4A)
SAH  A 901 ( 4.4A)
SAH  A 901 (-3.1A)
SAH  A 901 (-3.6A)
SAH  A 901 (-4.0A)
None
 0.66A 1eizA-3evcA:
15.1		 1eizA-3evcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LEU A 105
LYS A 183
 SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.0A)
SAM  A4633 ( 4.8A)
 0.66A 1eizA-3gczA:
15.3		 1eizA-3gczA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 261
GLY A 463
GLY A 462
LEU A 265
LEU A 266
 FAD  A 522 ( 4.0A)
None
None
None
None
 1.01A 1eizA-3gdnA:
2.3		 1eizA-3gdnA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gei TRNA MODIFICATION
GTPASE MNME

(Chlorobaculum
tepidum) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		6 ALA A  28
GLY A 106
PRO A 102
GLY A 101
GLY A 100
LEU A 113
 None
 1.27A 1eizA-3geiA:
undetectable		 1eizA-3geiA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE
ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		PF00890
(FAD_binding_2)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		6 GLY A 388
PRO B   2
GLY A 248
TRP B  48
PHE A 382
LEU A 383
 None
 1.29A 1eizA-3gyxA:
2.2		 1eizA-3gyxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7o GROUP 3 ALLERGEN
SMIPP-S YV6023A04

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 ALA A 198
GLY A 131
GLY A  30
GLY A 185
LEU A 143
 None
GOL  A 232 ( 4.0A)
None
None
None
 0.98A 1eizA-3h7oA:
undetectable		 1eizA-3h7oA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		5 ALA A 303
GLY A 247
GLY A 407
LEU A 241
LEU A 293
 None
 1.01A 1eizA-3hvyA:
3.9		 1eizA-3hvyA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		5 ALA A  18
GLY A 331
GLY A  13
GLY A  16
ARG A  54
 None
FAD  A 371 (-3.1A)
FAD  A 371 (-3.2A)
None
None
 0.99A 1eizA-3if9A:
undetectable		 1eizA-3if9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 GLY A 137
GLY A 168
LEU A 112
LEU A  70
LYS A 145
 None
 0.94A 1eizA-3ju1A:
undetectable		 1eizA-3ju1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kci PROBABLE E3
UBIQUITIN-PROTEIN
LIGASE HERC2

(Homo sapiens) 		PF00415
(RCC1) 		5 GLY A3956
GLY A3966
GLY A3967
LEU A3990
LEU A4298
 None
 1.00A 1eizA-3kciA:
undetectable		 1eizA-3kciA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLY A  86
TRP A  87
ARG A 163
LYS A 182
 SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
None
SFG  A 301 ( 4.1A)
 1.14A 1eizA-3lkzA:
15.4		 1eizA-3lkzA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pty ARABINOSYLTRANSFERAS
E C

(Mycobacterium
tuberculosis) 		PF14896
(Arabino_trans_C) 		5 ALA A 771
GLY A 780
LEU A 898
LEU A 945
LEU A 871
 None
 0.98A 1eizA-3ptyA:
undetectable		 1eizA-3ptyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		5 ALA A 194
GLY A 158
GLY A 197
GLY A 196
LEU A 353
 None
 0.98A 1eizA-3qfwA:
2.2		 1eizA-3qfwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc2 SUGAR
3-KETOREDUCTASE

(Actinomadura
kijaniata) 		PF01408
(GFO_IDH_MocA) 		5 ALA A  81
GLY A 178
GLY A 177
LEU A 232
LEU A 318
 NAP  A 336 ( 4.4A)
None
None
None
None
 0.93A 1eizA-3rc2A:
4.9		 1eizA-3rc2A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 262
GLY A 464
GLY A 463
LEU A 266
LEU A 267
 FAD  A 773 ( 4.0A)
None
None
FAD  A 773 ( 4.6A)
None
 0.99A 1eizA-3redA:
2.4		 1eizA-3redA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 ALA A 115
GLY A  24
GLY A  54
GLY A  53
LEU A  29
 None
 0.87A 1eizA-3rreA:
4.0		 1eizA-3rreA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 ALA A 256
GLY A 184
GLY A 275
GLY A 276
LEU A 218
 None
 0.82A 1eizA-3tbhA:
2.5		 1eizA-3tbhA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		5 ALA A 633
GLY A 622
GLY A 642
GLY A 641
LEU A 665
 None
 0.94A 1eizA-3txaA:
undetectable		 1eizA-3txaA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		6 ALA A 152
GLY A 146
GLY A 148
LEU A 102
LEU A 104
LEU A 138
 None
 1.12A 1eizA-3v9aA:
3.4		 1eizA-3v9aA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A1319
GLY A1479
GLY A1347
GLY A1348
LEU A1484
 None
None
BTI  A1901 (-3.1A)
BTI  A1901 (-4.3A)
None
 0.95A 1eizA-3va7A:
3.5		 1eizA-3va7A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		5 ALA A  30
GLY A  80
GLY A 111
GLY A  26
LEU A 116
 None
None
SO4  A 402 (-3.3A)
SO4  A 402 (-3.3A)
None
 0.88A 1eizA-3vzbA:
undetectable		 1eizA-3vzbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE

(Xenopus laevis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 371
GLY A 292
GLY A 288
GLY A 287
LEU A 299
 None
 0.78A 1eizA-3w0lA:
undetectable		 1eizA-3w0lA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 GLY A 106
PRO A 117
GLY A 115
GLY A 114
LEU A 134
 GDP  A1368 (-3.6A)
None
None
None
None
 0.99A 1eizA-4b46A:
4.6		 1eizA-4b46A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3y 3-KETOSTEROID
DEHYDROGENASE

(Rhodococcus
erythropolis) 		PF00890
(FAD_binding_2) 		5 ALA A 497
GLY A  16
GLY A  17
LEU A 195
LEU A 472
 FAD  A 551 ( 4.5A)
FAD  A 551 (-3.4A)
None
FAD  A 551 (-4.6A)
None
 0.90A 1eizA-4c3yA:
3.1		 1eizA-4c3yA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE

(Paraburkholderia
xenovorans) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A  21
GLY A  83
GLY A  85
TRP A  86
LEU A 322
 None
 0.99A 1eizA-4efiA:
undetectable		 1eizA-4efiA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		6 PRO A 185
GLY A 185
GLY A 186
LEU A 205
ARG A 239
LEU A 291
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.8A)
None
None
 0.91A 1eizA-4fzvA:
9.0		 1eizA-4fzvA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 ALA A 100
GLY A 354
GLY A 146
GLY A 147
LEU A 800
 None
 0.78A 1eizA-4iugA:
undetectable		 1eizA-4iugA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 108
GLY A 236
LEU A 167
LEU A 170
LEU A 114
 None
 0.83A 1eizA-4jatA:
undetectable		 1eizA-4jatA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyl ENOYL-COA HYDRATASE

(Thermoplasma
volcanium) 		PF00378
(ECH_1) 		5 ALA A 111
GLY A 140
GLY A 105
GLY A 107
LEU A 156
 None
None
CL  A 301 (-3.6A)
None
None
 0.96A 1eizA-4jylA:
undetectable		 1eizA-4jylA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  85
GLY A  86
TRP A  87
ARG A 160
LEU A 184
 SAH  A1001 (-4.3A)
SAH  A1001 (-3.2A)
SAH  A1001 (-3.9A)
None
None
 0.96A 1eizA-4k6mA:
15.0		 1eizA-4k6mA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 ALA A  95
GLY A 120
PRO A 123
GLY A 124
LEU A 142
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
None
UNX  A1016 ( 2.9A)
SAH  A1001 (-4.2A)
 0.56A 1eizA-4mtlA:
11.6		 1eizA-4mtlA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		7 ALA A 236
PRO A 280
GLY A 281
GLY A 282
LEU A 302
LEU A 383
LYS A 404
 SAM  A 601 (-3.2A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.6A)
SAM  A 601 ( 4.1A)
 0.62A 1eizA-4n49A:
17.8		 1eizA-4n49A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqi SH3
DOMAIN-CONTAINING
PROTEIN

(Dictyostelium
discoideum) 		PF08397
(IMD) 		5 GLY A  72
GLY A  66
GLY A  67
LEU A  58
LEU A  61
 None
 0.99A 1eizA-4nqiA:
undetectable		 1eizA-4nqiA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Deinococcus
radiodurans) 		PF02540
(NAD_synthase) 		5 ALA A 102
GLY A  53
GLY A  64
LEU A 155
LEU A  84
 None
 0.94A 1eizA-4q16A:
undetectable		 1eizA-4q16A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q48 DNA HELICASE RECQ

(Deinococcus
radiodurans) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 ALA A  42
GLY A  39
GLY A  40
LEU A  61
LEU A  62
 None
 0.73A 1eizA-4q48A:
2.1		 1eizA-4q48A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q48 DNA HELICASE RECQ

(Deinococcus
radiodurans) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 ALA A  42
GLY A  39
GLY A  40
LEU A  62
LEU A 117
 None
 0.92A 1eizA-4q48A:
2.1		 1eizA-4q48A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		5 ALA A  80
GLY A  73
GLY A 298
GLY A 299
LEU A  96
 None
None
None
None
SAH  A1000 (-4.0A)
 0.99A 1eizA-4qppA:
7.4		 1eizA-4qppA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		5 ALA A  80
GLY A  73
PRO A 297
GLY A 298
GLY A 299
 None
 0.93A 1eizA-4qppA:
7.4		 1eizA-4qppA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		5 GLY A  73
PRO A 297
GLY A 298
GLY A 299
LEU A 307
 None
 1.00A 1eizA-4qppA:
7.4		 1eizA-4qppA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqo L-SERINE DEHYDRATASE

(Legionella
pneumophila) 		PF03313
(SDH_alpha)
PF03315
(SDH_beta) 		5 GLY A  52
GLY A 449
GLY A 450
LEU A 116
LEU A 121
 None
 0.83A 1eizA-4rqoA:
undetectable		 1eizA-4rqoA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 ALA A 224
GLY A 407
GLY A 421
GLY A 420
LEU A 729
 None
 0.90A 1eizA-4umvA:
3.1		 1eizA-4umvA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca) 		PF07993
(NAD_binding_4) 		5 ALA A1318
GLY A1243
GLY A1262
LEU A1153
LEU A1160
 None
 0.85A 1eizA-4w4tA:
5.8		 1eizA-4w4tA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrw BEXL

(Amycolatopsis
orientalis) 		PF10604
(Polyketide_cyc2) 		5 ALA A 113
PRO A 118
GLY A 119
GLY A 120
LYS A   1
 None
 0.98A 1eizA-4xrwA:
undetectable		 1eizA-4xrwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqz PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 ALA A 116
GLY A 119
GLY A 118
LEU A   9
LEU A  72
 None
 0.99A 1eizA-4yqzA:
10.1		 1eizA-4yqzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		6 ALA A1484
GLY A1478
GLY A1473
LEU A1567
LEU A1564
LEU A1656
 None
 1.47A 1eizA-5a31A:
undetectable		 1eizA-5a31A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 ALA A 522
GLY A 243
TRP A 242
LEU A 205
LEU A 259
 None
 0.81A 1eizA-5ficA:
undetectable		 1eizA-5ficA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fus PUTATIVE ENOYL COA
HYDRATASE

(Burkholderia
cenocepacia) 		PF00378
(ECH_1) 		5 ALA A 140
GLY A 169
GLY A 134
GLY A 136
LEU A 185
 None
 0.94A 1eizA-5fusA:
undetectable		 1eizA-5fusA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 ALA A 522
GLY A 243
TRP A 242
LEU A 205
LEU A 259
 None
 0.80A 1eizA-5hqnA:
undetectable		 1eizA-5hqnA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		5 ALA A 524
GLY A 245
TRP A 244
LEU A 207
LEU A 261
 None
 0.87A 1eizA-5i85A:
undetectable		 1eizA-5i85A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A1319
GLY A1479
GLY A1347
GLY A1348
LEU A1484
 None
 0.94A 1eizA-5i8iA:
4.3		 1eizA-5i8iA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig8 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 5 ALA A 282
GLY A 301
GLY A 302
LEU A 172
LEU A 135
 None
 0.92A 1eizA-5ig8A:
undetectable		 1eizA-5ig8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLY A  86
TRP A  87
ARG A 163
LYS A 180
 SAM  A 311 (-3.2A)
SAM  A 311 ( 4.5A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.5A)
MLT  A 313 (-2.8A)
None
 1.31A 1eizA-5ikmA:
13.7		 1eizA-5ikmA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LYS A 180
 SAH  A1003 (-3.4A)
SAH  A1003 ( 4.6A)
SAH  A1003 (-3.0A)
SAH  A1003 (-3.4A)
None
 0.65A 1eizA-5jjrA:
13.8		 1eizA-5jjrA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		6 ALA A1484
GLY A1478
GLY A1473
LEU A1567
LEU A1564
LEU A1656
 None
 1.48A 1eizA-5lcwA:
undetectable		 1eizA-5lcwA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtf RHOMBOID PROTEASE
GLPG

(Escherichia
coli) 		no annotation 5 ALA A  93
GLY A 162
GLY A 163
LEU A 200
PHE A 153
 CL  A 302 ( 3.6A)
None
BNG  A 306 (-3.4A)
None
None
 0.98A 1eizA-5mtfA:
undetectable		 1eizA-5mtfA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		5 GLY J 278
GLY J 583
GLY J 584
LEU J 274
LEU J 273
 None
 0.95A 1eizA-5nilJ:
undetectable		 1eizA-5nilJ:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 6 GLY A  81
GLY A  85
GLY A  86
TRP A  87
ARG A 163
LYS A 182
 SAH  A1001 (-3.4A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.5A)
None
None
 1.22A 1eizA-5njuA:
14.7		 1eizA-5njuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  85
GLY A  86
TRP A  87
ARG A 160
LEU A 184
 SAH  A1001 ( 4.9A)
SAH  A1001 (-3.6A)
SAH  A1001 (-3.5A)
GOL  A1005 (-4.1A)
None
 0.95A 1eizA-5tmhA:
16.7		 1eizA-5tmhA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 5 ALA A  84
GLY A 169
GLY A 299
GLY A 300
LEU A  62
 None
None
None
42Y  A 118 ( 3.2A)
None
 0.99A 1eizA-5wgcA:
undetectable		 1eizA-5wgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
PERMEAE

(Streptococcus
pneumoniae) 		no annotation 5 GLY M  24
GLY M 350
GLY M 351
LEU M  20
LEU M  19
 None
 0.87A 1eizA-5xu1M:
undetectable		 1eizA-5xu1M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg8 PROBABLE INACTIVE
RECEPTOR KINASE
AT1G27190

(Arabidopsis
thaliana) 		no annotation 5 GLY B 134
GLY B 135
LEU B 103
LEU B 108
LEU B 120
 None
 0.98A 1eizA-6fg8B:
undetectable		 1eizA-6fg8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3w PROBABLE INACTIVE
RECEPTOR KINASE
AT1G27190

(Arabidopsis
thaliana) 		no annotation 5 GLY B 134
GLY B 135
LEU B 103
LEU B 108
LEU B 120
 None
 0.99A 1eizA-6g3wB:
undetectable		 1eizA-6g3wB:
undetectable