SIMILAR PATTERNS OF AMINO ACIDS FOR 1EII_A_RTLA135_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 GLN A 252
THR A 213
SER A 247
GLN A 207
 None
 1.43A 1eiiA-1ahiA:
0.0		 1eiiA-1ahiA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cl7 PROTEIN (IGG1
ANTIBODY 1696
(VARIABLE HEAVY
CHAIN))

(Mus musculus) 		PF07686
(V-set) 		4 GLN H   6
THR H 107
SER H   7
TYR H  90
 None
 1.35A 1eiiA-1cl7H:
0.0		 1eiiA-1cl7H:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 TYR A  89
GLN A 197
SER A 239
TYR A 243
 DCA  A 801 (-4.0A)
None
DCA  A 801 ( 4.1A)
B12  A 800 ( 4.6A)
 1.32A 1eiiA-1e1cA:
0.0		 1eiiA-1e1cA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 GLN P 476
SER P 475
TRP P 124
GLN P 139
 None
 1.33A 1eiiA-1e33P:
0.0		 1eiiA-1e33P:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2d TATA BOX ZINC FINGER
PROTEIN

(Mus musculus) 		PF00096
(zf-C2H2)
PF13894
(zf-C2H2_4) 		4 GLN C 146
THR C 124
SER C 145
GLN C 118
 None
 1.35A 1eiiA-1g2dC:
undetectable		 1eiiA-1g2dC:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		4 THR A  53
SER A  55
TYR A  60
TRP A 106
 None
 0.79A 1eiiA-1gglA:
7.3		 1eiiA-1gglA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxm GAMMA-DELTA T-CELL
RECEPTOR

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN B   8
THR B 117
SER B  11
TYR B  95
 None
 1.43A 1eiiA-1hxmB:
undetectable		 1eiiA-1hxmB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j05 ANTI-CEA MAB T84.66,
HEAVY CHAIN
ANTI-CEA MAB T84.66,
LIGHT CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 GLN H   6
SER H   7
TYR H  90
GLN L  38
 None
 1.48A 1eiiA-1j05H:
0.0		 1eiiA-1j05H:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		5 GLN A  38
THR A  53
SER A  55
TRP A 106
GLN A 108
 None
 1.09A 1eiiA-1kqxA:
8.0		 1eiiA-1kqxA:
73.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 GLN A 404
SER A 405
TYR A 583
GLN A 431
 None
 1.33A 1eiiA-1nl3A:
undetectable		 1eiiA-1nl3A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 TYR Q  97
GLN Q 398
THR Q 376
GLN Q 360
 None
 1.16A 1eiiA-1oh2Q:
1.8		 1eiiA-1oh2Q:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 TYR Q  97
THR Q 376
SER Q 396
GLN Q 360
 None
 1.43A 1eiiA-1oh2Q:
1.8		 1eiiA-1oh2Q:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 TYR Q 213
THR Q 248
TYR Q 228
GLN Q 257
 None
 1.39A 1eiiA-1oh2Q:
1.8		 1eiiA-1oh2Q:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 TYR A 438
THR A 335
SER A 312
TRP A 560
 None
CA  A 602 (-4.3A)
None
None
 1.47A 1eiiA-1ot5A:
undetectable		 1eiiA-1ot5A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 TYR A  42
SER A 397
TYR A  76
TRP A 138
 None
 1.32A 1eiiA-1pw4A:
undetectable		 1eiiA-1pw4A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 TYR B 348
GLN B 379
SER B 748
GLN B 419
 None
 1.50A 1eiiA-1t3qB:
undetectable		 1eiiA-1t3qB:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE

(Clostridium
perfringens) 		PF00722
(Glyco_hydro_16) 		4 TYR A 335
GLN A 195
THR A 199
SER A 197
 None
 1.11A 1eiiA-1upsA:
undetectable		 1eiiA-1upsA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xio ANABAENA SENSORY
RHODOPSIN

(Nostoc sp. PCC
7120) 		PF01036
(Bac_rhodopsin) 		4 GLN A 157
THR A 154
SER A 158
TYR A 165
 None
 1.18A 1eiiA-1xioA:
undetectable		 1eiiA-1xioA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqm KINDLING FLUORESCENT
PROTEIN

(Anemonia
sulcata) 		PF01353
(GFP) 		4 TYR A  72
SER A  83
TYR A 178
GLN A  39
 None
None
None
CH6  A  63 ( 3.5A)
 1.22A 1eiiA-1xqmA:
undetectable		 1eiiA-1xqmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypz T CELL RECEPTOR
DELTA

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN E   6
THR E 112
SER E   7
TYR E  86
 None
 1.39A 1eiiA-1ypzE:
undetectable		 1eiiA-1ypzE:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 4 TYR P 271
THR P 309
SER P 306
TRP P 278
 None
 1.41A 1eiiA-2btvP:
undetectable		 1eiiA-2btvP:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 TYR A 155
THR A 106
TYR A 108
TRP A 171
 None
 1.44A 1eiiA-2esnA:
undetectable		 1eiiA-2esnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		4 GLN A  60
THR A  71
TYR A  68
GLN A 100
 None
None
PE4  A4124 (-3.8A)
FMN  A4401 (-3.0A)
 1.22A 1eiiA-2gouA:
undetectable		 1eiiA-2gouA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 GLN A 156
THR A  18
SER A  22
GLN A 275
 None
 1.47A 1eiiA-2l7bA:
undetectable		 1eiiA-2l7bA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C

(Neurospora
crassa) 		PF00225
(Kinesin) 		4 GLN A 145
THR A 400
SER A 393
TYR A 397
 None
 1.40A 1eiiA-2owmA:
undetectable		 1eiiA-2owmA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 TYR A  89
GLN A 161
THR A 165
GLN A 400
 None
 1.45A 1eiiA-2po4A:
undetectable		 1eiiA-2po4A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 TYR A 868
TYR A 857
TRP A 860
GLN A 905
 None
 1.40A 1eiiA-2qepA:
0.7		 1eiiA-2qepA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE

(Escherichia
coli) 		PF02618
(YceG) 		4 TYR A 142
THR A 286
SER A 213
GLN A 126
 None
 1.38A 1eiiA-2r1fA:
undetectable		 1eiiA-2r1fA:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 GLN A  38
THR A  53
SER A  55
TRP A 106
GLN A 108
 None
 1.17A 1eiiA-2rcqA:
8.0		 1eiiA-2rcqA:
88.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
GLN A  38
TRP A 106
GLN A 108
 None
 1.14A 1eiiA-2rcqA:
8.0		 1eiiA-2rcqA:
88.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato bushy
stunt virus) 		PF00729
(Viral_coat) 		4 TYR A 155
THR A 228
SER A 226
GLN A 133
 None
 1.40A 1eiiA-2tbvA:
undetectable		 1eiiA-2tbvA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLN B 234
THR B 339
SER B 337
GLN B 197
 None
None
None
XAX  B1778 (-3.5A)
 1.32A 1eiiA-2w55B:
undetectable		 1eiiA-2w55B:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xiv HYPOTHETICAL
INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 THR A 463
SER A 414
TRP A 267
GLN A 431
 None
 1.41A 1eiiA-2xivA:
undetectable		 1eiiA-2xivA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		4 TYR A  88
GLN A 159
SER A 158
GLN A 173
 None
 1.41A 1eiiA-2xmzA:
undetectable		 1eiiA-2xmzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		4 GLN A 180
THR A 156
SER A 154
TRP A 172
 None
 1.35A 1eiiA-2ybqA:
undetectable		 1eiiA-2ybqA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apm PROTEIN-ARGININE
DEIMINASE TYPE-4

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 GLN A 286
THR A 268
SER A 270
GLN A 136
 None
 1.45A 1eiiA-3apmA:
undetectable		 1eiiA-3apmA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bew MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
GLYCOPROTEIN
HAPLOTYPE B21

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 156
SER A  69
TYR A   7
TRP A 164
 None
 1.14A 1eiiA-3bewA:
undetectable		 1eiiA-3bewA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc7 PUTATIVE
UNCHARACTERIZED
PROTEIN LP_3323

(Lactobacillus
plantarum) 		PF13472
(Lipase_GDSL_2) 		4 GLN A  99
THR A  64
SER A  67
TYR A  69
 None
 1.28A 1eiiA-3dc7A:
undetectable		 1eiiA-3dc7A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C)
PF02665
(Nitrate_red_gam) 		4 TYR B 100
THR B 225
TYR B  62
GLN C  41
 None
None
None
HEM  C 806 (-4.5A)
 1.41A 1eiiA-3egwB:
undetectable		 1eiiA-3egwB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esu ANTIBODY 14B7* LIGHT
CHAIN AND ANTIBODY
14B7* HEAVY CHAIN
LINKED WITH A
SYNTHETIC (GGGGS)4
LINKER

(Mus musculus) 		PF07686
(V-set) 		4 GLN F1006
SER F1007
TYR F1090
GLN F  38
 None
 1.49A 1eiiA-3esuF:
undetectable		 1eiiA-3esuF:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 GLN C 174
THR C 352
SER C 172
GLN C 241
 None
 1.32A 1eiiA-3gzdC:
undetectable		 1eiiA-3gzdC:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0z PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Streptococcus
pneumoniae) 		PF01380
(SIS) 		4 GLN A 166
THR A 187
SER A 183
TYR A  35
 None
 1.37A 1eiiA-3i0zA:
undetectable		 1eiiA-3i0zA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLN A 311
THR A 314
SER A 302
TYR A 300
 None
 1.29A 1eiiA-3iplA:
undetectable		 1eiiA-3iplA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC

(Escherichia
coli) 		no annotation 4 TYR A 374
THR A 229
SER A 449
GLN A 303
 None
 1.15A 1eiiA-3ly9A:
undetectable		 1eiiA-3ly9A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		4 TYR A 110
THR A  87
SER A 120
TYR A 118
 None
 1.29A 1eiiA-3q6tA:
0.9		 1eiiA-3q6tA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qg7 AP4-24H11 ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN H  81
THR H  70
SER H  68
GLN H  77
 None
None
P6G  H 229 (-4.2A)
None
 1.44A 1eiiA-3qg7H:
undetectable		 1eiiA-3qg7H:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwb PROBABLE QUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TYR A 307
THR A 324
SER A 321
GLN A 132
 None
None
None
NDP  A 335 (-3.6A)
 1.38A 1eiiA-3qwbA:
undetectable		 1eiiA-3qwbA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6d PUTATIVE
TRIOSEPHOSPHATE
ISOMERASE

(Coccidioides
immitis) 		PF00121
(TIM) 		4 THR A  31
SER A  29
TYR A  34
GLN A  96
 None
 1.02A 1eiiA-3s6dA:
undetectable		 1eiiA-3s6dA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 GLN A 215
SER A 213
TYR A 147
GLN A  88
 None
 1.29A 1eiiA-3tlkA:
undetectable		 1eiiA-3tlkA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		4 THR A 353
SER A 428
TYR A 223
GLN A 357
 None
 1.36A 1eiiA-3vtaA:
undetectable		 1eiiA-3vtaA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 TYR A 236
GLN A 485
SER A 509
TRP A 351
 None
 1.32A 1eiiA-3w6qA:
undetectable		 1eiiA-3w6qA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buh CLONE M0418 SCFV

(Homo sapiens) 		PF07686
(V-set) 		4 GLN A   6
SER A   7
TYR A  94
GLN A 180
 None
 1.45A 1eiiA-4buhA:
undetectable		 1eiiA-4buhA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		4 THR A 246
TYR A 248
TRP A 225
GLN A 262
 None
 1.36A 1eiiA-4ci8A:
undetectable		 1eiiA-4ci8A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxo LEA X(6) GFP-LIKE
PROTEINS

(synthetic
construct) 		PF01353
(GFP) 		4 TYR A  71
SER A  82
TYR A 177
GLN A  38
 None
None
None
CR8  A  63 ( 3.7A)
 1.48A 1eiiA-4dxoA:
undetectable		 1eiiA-4dxoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		4 TYR A 308
GLN A 396
THR A 359
SER A 263
 None
 1.44A 1eiiA-4f7aA:
undetectable		 1eiiA-4f7aA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963

(Streptomyces
coelicolor) 		no annotation 4 GLN B  95
THR B 151
SER B 149
TRP B 393
 None
 1.05A 1eiiA-4gt2B:
undetectable		 1eiiA-4gt2B:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuz ANTIBODY 4A5 HEAVY
CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN H   6
THR H 114
SER H   7
TYR H  94
 None
 1.31A 1eiiA-4kuzH:
undetectable		 1eiiA-4kuzH:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 GLN A  59
THR A 314
TYR A 315
GLN A 343
 None
 1.41A 1eiiA-4lvqA:
undetectable		 1eiiA-4lvqA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		PF09084
(NMT1) 		4 GLN A 249
THR A  19
SER A 229
TYR A 219
 None
 1.40A 1eiiA-4nmyA:
undetectable		 1eiiA-4nmyA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 TYR A 844
GLN A 820
THR A 840
TRP A 843
 None
 1.40A 1eiiA-4o9xA:
undetectable		 1eiiA-4o9xA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 SER A 404
TYR A 380
TRP A 371
GLN A 417
 None
 1.33A 1eiiA-4pvgA:
1.1		 1eiiA-4pvgA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql0 FILAMENTOUS
HEMAGGLUTININ
TRANSPORTER PROTEIN
FHAC

(Bordetella
pertussis) 		PF03865
(ShlB)
PF08479
(POTRA_2)
PF17287
(POTRA_3) 		4 TYR A 447
THR A 527
SER A 529
TYR A 547
 None
 1.19A 1eiiA-4ql0A:
1.5		 1eiiA-4ql0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qre METHIONYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 TYR A 123
THR A 133
SER A 128
TRP A 237
 None
3BG  A 601 (-3.7A)
None
None
 1.41A 1eiiA-4qreA:
undetectable		 1eiiA-4qreA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
HEAVY CHAIN
HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 GLN H   6
SER H   7
TYR H  90
GLN L  38
 None
 1.48A 1eiiA-4rqqH:
undetectable		 1eiiA-4rqqH:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tl3 ANABAENA SENSORY
RHODOPSIN

(Nostoc sp. PCC
7120) 		PF01036
(Bac_rhodopsin) 		4 GLN A 157
THR A 154
SER A 158
TYR A 165
 None
 1.20A 1eiiA-4tl3A:
undetectable		 1eiiA-4tl3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 THR A 137
SER A 185
TYR A 183
TRP A 149
 None
 1.36A 1eiiA-4uaqA:
undetectable		 1eiiA-4uaqA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 GLN A 138
THR A 137
TRP A 621
GLN A 645
 None
 1.49A 1eiiA-4xwhA:
undetectable		 1eiiA-4xwhA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a20 MAJOR TAIL PROTEIN
GP17.1

(Bacillus phage
SPP1) 		PF06199
(Phage_tail_2) 		4 TYR H 104
GLN H  16
THR H  22
GLN H  32
 None
 1.20A 1eiiA-5a20H:
undetectable		 1eiiA-5a20H:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 TYR A 752
GLN A 693
SER A 692
GLN A1065
 U  C   5 ( 4.1A)
U  C   5 ( 3.0A)
U  C   7 ( 2.5A)
None
 1.28A 1eiiA-5aorA:
undetectable		 1eiiA-5aorA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epd GLYCEROL TRINITRATE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		4 GLN A  60
THR A  71
TYR A  68
GLN A 100
 None
 1.15A 1eiiA-5epdA:
undetectable		 1eiiA-5epdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 SER A 404
TYR A 380
TRP A 371
GLN A 417
 None
 1.32A 1eiiA-5i6vA:
undetectable		 1eiiA-5i6vA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		4 GLN A 392
THR A 431
TYR A 432
GLN A 362
 None
 1.37A 1eiiA-5j5uA:
undetectable		 1eiiA-5j5uA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1

(Mus musculus) 		PF01094
(ANF_receptor) 		4 THR A 106
SER A 104
TYR A 139
TRP A 359
 None
 1.37A 1eiiA-5kc9A:
0.9		 1eiiA-5kc9A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1x HMPV F1 SUBUNIT

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		4 GLN B 312
THR B 317
TYR B 310
GLN B 346
 None
 1.23A 1eiiA-5l1xB:
undetectable		 1eiiA-5l1xB:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		4 TYR A 175
GLN A  63
TYR A 102
GLN A 212
 None
 1.15A 1eiiA-5ltqA:
undetectable		 1eiiA-5ltqA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans) 		PF04261
(Dyp_perox) 		4 GLN A  95
THR A 151
SER A 149
TRP A 393
 None
 1.04A 1eiiA-5mapA:
undetectable		 1eiiA-5mapA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC

(synthetic
construct) 		no annotation 4 TYR D 260
GLN D  73
TYR D 112
GLN D 297
 None
CR2  D  70 ( 4.9A)
CR2  D  70 ( 4.8A)
None
 1.21A 1eiiA-5mwcD:
undetectable		 1eiiA-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8d FIBER

(Murine
mastadenovirus
B) 		no annotation 4 GLN A 744
THR A 746
TYR A 747
GLN A 683
 None
None
None
GOL  A 801 (-4.0A)
 1.35A 1eiiA-5n8dA:
undetectable		 1eiiA-5n8dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 GLN A  26
TYR A  16
TRP A  49
GLN A  53
 None
 1.42A 1eiiA-5te1A:
undetectable		 1eiiA-5te1A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
pombe) 		no annotation 4 GLN A 215
THR A 214
SER A 216
GLN A 142
 None
 1.46A 1eiiA-5wjcA:
undetectable		 1eiiA-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqw N-ACETYLGLUCOSAMINID
ASE

(Clostridium
perfringens) 		PF01832
(Glucosaminidase) 		4 GLN A1085
SER A1074
TYR A1067
GLN A 892
 None
None
None
EDO  A1201 ( 4.3A)
 1.48A 1eiiA-5wqwA:
undetectable		 1eiiA-5wqwA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 TYR A 186
THR A 115
TYR A 116
GLN A 108
 None
None
GOL  A 402 (-4.5A)
None
 1.49A 1eiiA-5x18A:
undetectable		 1eiiA-5x18A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4t PHOTOACTIVATED
ADENYLYL CYCLASE

(Cyanobacteria) 		PF00211
(Guanylate_cyc)
PF04940
(BLUF) 		4 THR A 330
SER A 334
TRP A 303
GLN A 216
 None
 1.42A 1eiiA-5x4tA:
undetectable		 1eiiA-5x4tA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd2 NUDIX FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF00293
(NUDIX)
PF00300
(His_Phos_1) 		4 GLN A 202
THR A 300
TYR A 315
GLN A 195
 None
None
GOL  A 403 (-4.8A)
None
 1.47A 1eiiA-5xd2A:
undetectable		 1eiiA-5xd2A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 TYR A 737
THR A 724
SER A 693
TYR A 728
 None
 1.35A 1eiiA-5y4fA:
undetectable		 1eiiA-5y4fA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yd5 SCFV 4B08

(Mus musculus) 		no annotation 4 GLN A   8
SER A   9
TYR A  96
GLN A 183
 None
 1.37A 1eiiA-5yd5A:
undetectable		 1eiiA-5yd5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1

(Moorea
bouillonii) 		no annotation 4 GLN A  78
THR A  76
SER A  63
TYR A  66
 None
 1.33A 1eiiA-6b3bA:
undetectable		 1eiiA-6b3bA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejg SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 4 GLN C 175
SER C 176
TYR C 263
GLN C  80
 None
 1.42A 1eiiA-6ejgC:
undetectable		 1eiiA-6ejgC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 4 TYR B 216
THR B  32
SER B 406
TYR B  26
 D5E  B 501 ( 4.5A)
D5E  B 501 (-3.4A)
D5E  B 501 ( 3.4A)
D5E  B 501 (-3.7A)
 1.08A 1eiiA-6fd2B:
undetectable		 1eiiA-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 4 TYR B 123
THR B 365
SER B 116
TYR B 119
 None
 1.48A 1eiiA-6fosB:
undetectable		 1eiiA-6fosB:
undetectable