SIMILAR PATTERNS OF AMINO ACIDS FOR 1EII_A_RTLA135_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwu ENOYL ACP REDUCTASE

(Brassica napus) 		PF13561
(adh_short_C2) 		5 ALA A 272
ILE A 226
LEU A 133
LEU A 186
LEU A  40
 None
None
None
NAD  A 501 (-3.6A)
None
 1.23A 1eiiA-1cwuA:
0.0		 1eiiA-1cwuA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE

(Escherichia
coli) 		PF01634
(HisG)
PF08029
(HisG_C) 		5 THR A 129
ILE A 196
LEU A 106
ARG A 137
LEU A  82
 None
 1.22A 1eiiA-1h3dA:
0.0		 1eiiA-1h3dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		5 ALA A 249
ILE A 309
ARG A 256
LEU A 269
LEU A 227
 None
None
A  B  36 ( 3.7A)
None
None
 0.94A 1eiiA-1h3eA:
0.0		 1eiiA-1h3eA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 5 ALA A 146
ILE A 205
THR A 258
LEU A 183
LEU A  84
 None
 1.32A 1eiiA-1onsA:
0.0		 1eiiA-1onsA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otw COENZYME PQQ
SYNTHESIS PROTEIN C

(Klebsiella
pneumoniae) 		PF03070
(TENA_THI-4) 		5 THR A 146
ALA A 150
ILE A  43
PHE A 149
LEU A 218
 PQQ  A 500 (-3.7A)
PEO  A 600 (-3.1A)
None
None
None
 1.23A 1eiiA-1otwA:
undetectable		 1eiiA-1otwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 ALA A 377
ILE A 423
LEU A 481
LEU A 383
LEU A 510
 None
 1.41A 1eiiA-1oywA:
0.0		 1eiiA-1oywA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 ALA A 377
ILE A 423
PHE A 374
LEU A 481
LEU A 510
 None
 1.31A 1eiiA-1oywA:
0.0		 1eiiA-1oywA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		5 THR A 110
ILE A   5
THR A 165
LEU A 117
LEU A 142
 FMT  A3010 (-2.7A)
None
None
None
None
 1.07A 1eiiA-1r4pA:
0.0		 1eiiA-1r4pA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfl PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Escherichia
coli) 		PF01926
(MMR_HSR1) 		5 ALA A  87
ARG A  89
LEU A  24
LEU A 163
LEU A  46
 None
 1.30A 1eiiA-1rflA:
0.0		 1eiiA-1rflA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00378
(ECH_1) 		5 THR A 150
ILE A  38
LEU A  36
LEU A 114
LEU A 100
 None
 1.35A 1eiiA-1sg4A:
0.0		 1eiiA-1sg4A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		5 ALA A 129
ILE A 118
PHE A 326
LEU A 120
LEU A  95
 None
 1.40A 1eiiA-1vgpA:
0.0		 1eiiA-1vgpA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wym TRANSGELIN-2

(Homo sapiens) 		PF00307
(CH) 		5 ALA A 130
ILE A 102
THR A 120
LEU A 121
LEU A  61
 None
 1.35A 1eiiA-1wymA:
undetectable		 1eiiA-1wymA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Mus musculus) 		PF00005
(ABC_tran)
PF14396
(CFTR_R) 		5 MET A 645
ILE A 661
THR A 665
LEU A 666
LEU A 610
 None
 1.33A 1eiiA-1xfaA:
undetectable		 1eiiA-1xfaA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		5 ALA A  39
PHE A  40
ARG A  42
LEU A 121
LEU A  96
 None
 1.08A 1eiiA-1xkdA:
undetectable		 1eiiA-1xkdA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yac YCAC GENE PRODUCT

(Escherichia
coli) 		PF00857
(Isochorismatase) 		5 ALA A  13
ILE A  82
THR A  57
LEU A  56
LEU A  43
 None
 1.41A 1eiiA-1yacA:
undetectable		 1eiiA-1yacA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC

(Homo sapiens) 		PF01063
(Aminotran_4) 		5 ALA A 163
PHE A 164
LEU A 108
LEU A 135
LEU A 185
 None
 0.99A 1eiiA-2abjA:
undetectable		 1eiiA-2abjA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 687
ILE A 899
THR A 877
LEU A 880
LEU A 700
 None
None
BHM  A   1 (-3.0A)
None
None
 1.37A 1eiiA-2ax9A:
undetectable		 1eiiA-2ax9A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 LYS A 187
ILE A 231
THR A 226
ARG A 288
ARG A 293
 FAD  A2001 (-2.8A)
None
FAD  A2001 (-3.6A)
None
FAD  A2001 (-3.8A)
 1.15A 1eiiA-2g37A:
undetectable		 1eiiA-2g37A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 ALA A 519
ILE A 446
ARG A 531
LEU A 472
LEU A 512
 None
 1.37A 1eiiA-2g3nA:
undetectable		 1eiiA-2g3nA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		5 THR A  91
ALA A  72
ILE A  63
LEU A 117
LEU A  97
 None
 1.13A 1eiiA-2hf8A:
undetectable		 1eiiA-2hf8A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		5 ALA A 239
THR A  50
LEU A 230
LEU A  22
LEU A  81
 None
 1.16A 1eiiA-2ivdA:
undetectable		 1eiiA-2ivdA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kt2 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF00403
(HMA) 		5 THR A  48
ALA A  52
LYS A  63
THR A   7
LEU A  42
 None
 1.21A 1eiiA-2kt2A:
undetectable		 1eiiA-2kt2A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8b PROTEIN TRAI

(Escherichia
coli) 		no annotation 5 ILE A 466
THR A 518
ARG A 527
LEU A 519
LEU A 433
 None
 1.21A 1eiiA-2l8bA:
undetectable		 1eiiA-2l8bA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		5 THR C 245
ALA C 243
LEU C  89
LEU C  96
LEU C 253
 None
 1.29A 1eiiA-2nn3C:
undetectable		 1eiiA-2nn3C:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		5 ALA A 160
ILE A 169
THR A 315
LEU A 262
LEU A 186
 None
 1.37A 1eiiA-2obmA:
undetectable		 1eiiA-2obmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ALA B 625
ARG B 577
LEU B 506
LEU B 515
LEU B 689
 None
 1.41A 1eiiA-2rhqB:
undetectable		 1eiiA-2rhqB:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		5 MET A  20
ILE A 290
PHE A  55
LEU A   8
LEU A 183
 None
 1.06A 1eiiA-2uutA:
undetectable		 1eiiA-2uutA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkt CTP SYNTHASE 2

(Homo sapiens) 		PF00117
(GATase) 		5 ALA A 410
ILE A 375
THR A 378
PHE A 409
LEU A 379
 None
 1.22A 1eiiA-2vktA:
undetectable		 1eiiA-2vktA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		5 MET A 154
THR A 171
ALA A 143
ILE A 118
THR A 114
 None
 1.28A 1eiiA-3eegA:
undetectable		 1eiiA-3eegA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		5 ILE A 141
THR A 135
PHE A 215
LEU A 132
LEU A 166
 None
 1.22A 1eiiA-3ehmA:
undetectable		 1eiiA-3ehmA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ing HOMOSERINE
DEHYDROGENASE

(Thermoplasma
acidophilum) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 ALA A 142
ILE A   7
PHE A 151
LEU A 101
LEU A 120
 NDP  A 326 (-4.8A)
None
None
None
None
 1.37A 1eiiA-3ingA:
undetectable		 1eiiA-3ingA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 THR E 410
ALA E 413
LEU E 247
LEU E 384
LEU E 447
 None
 1.18A 1eiiA-3kfuE:
undetectable		 1eiiA-3kfuE:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Thermoanaerobacter
pseudethanolicus) 		PF00724
(Oxidored_FMN) 		5 THR A  45
ALA A  47
ILE A  74
THR A  59
LEU A  72
 None
 1.37A 1eiiA-3krzA:
undetectable		 1eiiA-3krzA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l84 TRANSKETOLASE

(Campylobacter
jejuni) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 THR A 240
ALA A 238
ILE A 146
LEU A  61
LEU A 224
 None
 1.15A 1eiiA-3l84A:
undetectable		 1eiiA-3l84A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l84 TRANSKETOLASE

(Campylobacter
jejuni) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 THR A 240
ILE A 146
LEU A  61
LEU A  35
LEU A 224
 None
 1.06A 1eiiA-3l84A:
undetectable		 1eiiA-3l84A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m51 14-3-3-LIKE PROTEIN
C

(Nicotiana
tabacum) 		PF00244
(14-3-3) 		5 THR A 167
ALA A 165
THR A 154
LEU A 155
LEU A 200
 None
 1.13A 1eiiA-3m51A:
undetectable		 1eiiA-3m51A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 THR B 536
ARG B 343
LEU B 375
LEU B 408
LEU B 230
 None
CL  B1131 (-3.8A)
None
None
None
 1.25A 1eiiA-3p8cB:
undetectable		 1eiiA-3p8cB:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sll PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 ALA A 121
ILE A  13
LEU A  15
LEU A  18
LEU A 194
 None
 1.31A 1eiiA-3sllA:
undetectable		 1eiiA-3sllA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slu M23 PEPTIDASE DOMAIN
PROTEIN

(Neisseria
meningitidis) 		PF01551
(Peptidase_M23) 		5 ALA A 302
ILE A 331
THR A 339
LEU A 340
LEU A 344
 None
 1.20A 1eiiA-3sluA:
undetectable		 1eiiA-3sluA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 MET A 323
ALA A 403
ILE A 505
LEU A 396
LEU A 389
 None
 1.23A 1eiiA-3tchA:
undetectable		 1eiiA-3tchA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 ALA A 245
ILE A 715
THR A 692
PHE A 554
LEU A 426
 None
 1.33A 1eiiA-3ue1A:
undetectable		 1eiiA-3ue1A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		5 THR A 120
ALA A 118
ILE A 208
LEU A 362
LEU A 165
 None
None
None
HEM  A 501 ( 4.4A)
None
 1.36A 1eiiA-3wecA:
undetectable		 1eiiA-3wecA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 THR A 119
ALA A 115
THR A  47
LEU A  96
LEU A  57
 None
 1.16A 1eiiA-3wkyA:
undetectable		 1eiiA-3wkyA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am6 ACTIN-LIKE PROTEIN
ARP8

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 THR A 717
ALA A 714
ILE A 503
THR A 508
LEU A 526
 None
 1.34A 1eiiA-4am6A:
undetectable		 1eiiA-4am6A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 PHE A 328
ARG A 331
LEU A 389
LEU A 352
LEU A 220
 None
 1.28A 1eiiA-4b56A:
1.0		 1eiiA-4b56A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 157
ILE A 120
THR A 288
LEU A 287
LEU A 160
 None
 1.36A 1eiiA-4bgqA:
undetectable		 1eiiA-4bgqA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 THR A 532
ALA A 506
LYS A 726
LEU A 393
LEU A 586
 None
 1.38A 1eiiA-4cakA:
undetectable		 1eiiA-4cakA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		5 ALA A  37
ILE A  60
THR A  89
LEU A 125
LEU A 276
 None
 1.29A 1eiiA-4d1iA:
undetectable		 1eiiA-4d1iA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus) 		PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel) 		5 MET A 405
THR A 369
ALA A 373
ILE A 409
LEU A 397
 None
 1.19A 1eiiA-4d2iA:
undetectable		 1eiiA-4d2iA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djb E4-ORF3

(Human
mastadenovirus
C) 		PF06931
(Adeno_E4_ORF3) 		5 THR A  96
ALA A  20
ILE A  51
LEU A  28
LEU A  13
 None
 1.34A 1eiiA-4djbA:
undetectable		 1eiiA-4djbA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0e POLY [ADP-RIBOSE]
POLYMERASE 15

(Homo sapiens) 		PF00644
(PARP) 		5 MET A 593
ALA A 571
ILE A 503
PHE A 638
ARG A 533
 None
 1.15A 1eiiA-4f0eA:
undetectable		 1eiiA-4f0eA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2n SUPEROXIDE DISMUTASE

(Leishmania
major) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 THR A  90
ALA A  88
LEU A  29
LEU A 180
LEU A  70
 None
 1.31A 1eiiA-4f2nA:
undetectable		 1eiiA-4f2nA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f48 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF00563
(EAL) 		5 MET A 108
PHE A  21
LEU A  82
LEU A  23
LEU A 128
 None
 1.41A 1eiiA-4f48A:
undetectable		 1eiiA-4f48A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhy HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis) 		PF14730
(DUF4468) 		5 ALA A 137
ILE A 115
PHE A 159
LEU A 170
LEU A  90
 None
 1.38A 1eiiA-4jhyA:
undetectable		 1eiiA-4jhyA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jot ENOYL-COA HYDRATASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF00378
(ECH_1) 		5 MET A 107
THR A   9
ALA A  25
LEU A 124
LEU A  48
 None
 1.18A 1eiiA-4jotA:
undetectable		 1eiiA-4jotA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldz TRANSCRIPTIONAL
REGULATORY PROTEIN
DESR

(Bacillus
subtilis) 		PF00072
(Response_reg)
PF00196
(GerE) 		5 THR A 139
ILE A  78
THR A  80
LEU A 101
LEU A 131
 None
None
BEF  A 202 (-3.7A)
None
None
 1.22A 1eiiA-4ldzA:
undetectable		 1eiiA-4ldzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 ALA A 342
ILE A 171
THR A 199
PHE A 379
LEU A 104
 None
 1.34A 1eiiA-4lihA:
undetectable		 1eiiA-4lihA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n30 PROTEIN DISULFIDE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13462
(Thioredoxin_4) 		5 THR A 193
THR A 185
ARG A 195
LEU A 186
LEU A 215
 None
 1.41A 1eiiA-4n30A:
undetectable		 1eiiA-4n30A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		5 ALA A 117
ILE A 166
THR A 159
LEU A 100
LEU A 310
 None
 1.20A 1eiiA-4oanA:
undetectable		 1eiiA-4oanA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens) 		PF08389
(Xpo1) 		5 THR B 784
ALA B 782
LEU B 767
LEU B 799
LEU B 752
 None
 1.36A 1eiiA-4ol0B:
undetectable		 1eiiA-4ol0B:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 524
ARG A 511
LEU A 691
LEU A 466
LEU A 493
 None
 1.33A 1eiiA-4oqjA:
undetectable		 1eiiA-4oqjA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcv BDCA (YJGI)

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 ALA A 113
ILE A  85
ARG A  63
LEU A 102
LEU A 153
 None
 1.30A 1eiiA-4pcvA:
undetectable		 1eiiA-4pcvA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A  39
ILE A 111
LEU A  62
LEU A  55
LEU A  32
 None
 1.25A 1eiiA-4plsA:
undetectable		 1eiiA-4plsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A  81
ILE A 153
LEU A 104
LEU A  97
LEU A  74
 None
 1.16A 1eiiA-4plsA:
undetectable		 1eiiA-4plsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A 123
ILE A 195
LEU A 146
LEU A 139
LEU A 116
 None
 1.40A 1eiiA-4plsA:
undetectable		 1eiiA-4plsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A 165
ILE A 237
LEU A 188
LEU A 181
LEU A 158
 None
 1.32A 1eiiA-4plsA:
undetectable		 1eiiA-4plsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 THR A 668
ALA A 747
ILE A 680
LEU B 928
ARG B 958
 None
 1.37A 1eiiA-4qiwA:
undetectable		 1eiiA-4qiwA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		5 MET A 146
ALA A 182
THR A 287
LEU A 272
LEU A 190
 None
 1.10A 1eiiA-4rgqA:
undetectable		 1eiiA-4rgqA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnw AVERMECTIN-SENSITIVE
GLUTAMATE-GATED
CHLORIDE CHANNEL
GLUCL ALPHA

(Caenorhabditis
elegans) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 THR A  90
ALA A 149
LEU A  36
LEU A  55
LEU A 128
 None
 1.37A 1eiiA-4tnwA:
undetectable		 1eiiA-4tnwA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD

(Mycolicibacterium
smegmatis) 		PF10017
(Methyltransf_33) 		5 ALA A  77
ILE A 164
LEU A  85
LEU A  82
LEU A 183
 None
 1.10A 1eiiA-4uy6A:
undetectable		 1eiiA-4uy6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3q YIII_M4_AII

(synthetic
construct) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ALA A  81
ILE A 153
LEU A 104
LEU A  97
LEU A  74
 None
 1.29A 1eiiA-4v3qA:
undetectable		 1eiiA-4v3qA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3q YIII_M4_AII

(synthetic
construct) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ALA A 165
ILE A 237
LEU A 188
LEU A 181
LEU A 158
 None
 1.38A 1eiiA-4v3qA:
undetectable		 1eiiA-4v3qA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh0 PUTATIVE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		5 ALA A  13
ILE A  82
THR A  57
LEU A  56
LEU A  43
 None
 1.34A 1eiiA-4wh0A:
undetectable		 1eiiA-4wh0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 MET A 536
ALA A 509
ILE A 744
ARG A 483
LEU A 498
 None
 1.11A 1eiiA-4xhjA:
undetectable		 1eiiA-4xhjA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01008
(IF-2B)
PF01008
(IF-2B) 		5 ALA C 299
ARG G 438
LEU G 341
LEU G 439
LEU G 329
 None
 1.37A 1eiiA-5b04C:
undetectable		 1eiiA-5b04C:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		5 MET A 212
ALA A  78
THR A 364
ARG A  41
LEU A  31
 None
 1.31A 1eiiA-5c2iA:
undetectable		 1eiiA-5c2iA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyu CONSERVED MEMBRANE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF05108
(T7SS_ESX1_EccB) 		5 ALA A 225
THR A 294
ARG A 213
LEU A 330
LEU A 199
 None
 1.17A 1eiiA-5cyuA:
undetectable		 1eiiA-5cyuA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 5 THR B 819
ALA B 816
ILE B 914
LEU B 921
LEU B 835
 None
 1.24A 1eiiA-5dlqB:
undetectable		 1eiiA-5dlqB:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE

(Chromohalobacter
salexigens) 		PF00120
(Gln-synt_C) 		5 ALA A 365
ILE A 216
PHE A 305
ARG A 121
LEU A 222
 None
 1.38A 1eiiA-5dm3A:
undetectable		 1eiiA-5dm3A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ALA A 325
PHE A 275
ARG A 278
LEU A 336
LEU A 167
 None
 1.16A 1eiiA-5gz4A:
0.9		 1eiiA-5gz4A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ALA A 325
PHE A 275
LEU A 336
LEU A 299
LEU A 167
 None
 1.13A 1eiiA-5gz4A:
0.9		 1eiiA-5gz4A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd0 ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00620
(RhoGAP) 		5 ILE A 919
THR A1030
ARG A 995
LEU A1031
LEU A 996
 None
 1.35A 1eiiA-5jd0A:
undetectable		 1eiiA-5jd0A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvo ARGININE REPRESSOR

(Corynebacterium
pseudotuberculosis) 		PF02863
(Arg_repressor_C) 		5 THR A 109
PHE A 155
ARG A 159
LEU A  94
LEU A  87
 None
 1.27A 1eiiA-5jvoA:
undetectable		 1eiiA-5jvoA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k50 L-THREONINE
3-DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 5 MET A1217
ALA A1021
THR A1179
LEU A1045
LEU A1077
 None
None
None
None
NAD  A1401 (-4.3A)
 1.35A 1eiiA-5k50A:
undetectable		 1eiiA-5k50A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT

(Lactococcus
lactis;
Lactococcus
lactis) 		PF01180
(DHO_dh)
PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		5 ALA B 233
THR A 198
LEU A 220
LEU B  51
LEU A 213
 FES  B 302 ( 4.3A)
FMN  A 401 ( 4.7A)
None
FAD  B 301 ( 4.2A)
None
 1.17A 1eiiA-5kswB:
undetectable		 1eiiA-5kswB:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfd YIIIM''6AII

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A 123
ILE A 195
LEU A 146
LEU A 139
LEU A 116
 None
 1.37A 1eiiA-5mfdA:
undetectable		 1eiiA-5mfdA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfd YIIIM''6AII

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A 165
ILE A 237
LEU A 188
LEU A 181
LEU A 158
 None
 1.28A 1eiiA-5mfdA:
undetectable		 1eiiA-5mfdA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfo YIIIM3AIII

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A  39
ILE A 111
LEU A  62
LEU A  55
LEU A  32
 None
 1.27A 1eiiA-5mfoA:
undetectable		 1eiiA-5mfoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfo YIIIM3AIII

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A  81
ILE A 153
LEU A 104
LEU A  97
LEU A  74
 None
 1.34A 1eiiA-5mfoA:
undetectable		 1eiiA-5mfoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		5 THR A 130
ALA A 134
ARG A 228
LEU A 189
LEU A 224
 None
 1.16A 1eiiA-5mscA:
undetectable		 1eiiA-5mscA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 5 THR B 214
ALA B 182
THR B 208
LEU B 134
LEU B 146
 None
 1.34A 1eiiA-5swiB:
1.0		 1eiiA-5swiB:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umf RIBULOSE-PHOSPHATE
3-EPIMERASE

(Neisseria
gonorrhoeae) 		PF00834
(Ribul_P_3_epim) 		5 ALA A  85
ILE A 175
PHE A  35
LEU A 114
LEU A  68
 None
 1.20A 1eiiA-5umfA:
undetectable		 1eiiA-5umfA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf4 UNCHARACTERIZED
PROTEIN

(Thermus
aquaticus) 		PF03781
(FGE-sulfatase) 		5 ALA A 297
THR A 279
LEU A 253
LEU A 207
LEU A 304
 None
 1.31A 1eiiA-5vf4A:
undetectable		 1eiiA-5vf4A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xaw SODIUM CHANNEL
SUBUNIT BETA-4

(Homo sapiens) 		PF07686
(V-set) 		5 ALA A  75
PHE A  76
LEU A 121
LEU A  79
ARG A 100
 PG4  A 202 ( 4.5A)
P33  A 201 ( 4.9A)
None
None
PG4  A 202 (-4.0A)
 1.38A 1eiiA-5xawA:
undetectable		 1eiiA-5xawA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 THR A 292
ALA A 344
THR A 445
LEU A  96
LEU A 399
 None
 1.39A 1eiiA-5xh9A:
undetectable		 1eiiA-5xh9A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0m -

(-) 		no annotation 5 ALA A  81
ILE A 269
THR A 309
LEU A 310
LEU A 283
 None
 1.32A 1eiiA-5y0mA:
undetectable		 1eiiA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bma INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Campylobacter
jejuni) 		no annotation 5 ALA A  85
ILE A  67
LEU A  91
LEU A 115
LEU A 239
 None
 1.20A 1eiiA-6bmaA:
undetectable		 1eiiA-6bmaA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 5 ALA A 298
ILE A 266
ARG A 283
LEU A 341
LEU A 287
 None
 1.39A 1eiiA-6d46A:
undetectable		 1eiiA-6d46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis) 		no annotation 5 MET A  15
ALA A  33
PHE A  52
LEU A  72
LEU A  26
 None
 1.39A 1eiiA-6f2cA:
undetectable		 1eiiA-6f2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 5 THR A 196
ALA A 200
ILE A 619
LEU A 621
LEU A 703
 None
None
None
HEM  A1001 (-4.8A)
None
 1.25A 1eiiA-6fwfA:
undetectable		 1eiiA-6fwfA:
undetectable