SIMILAR PATTERNS OF AMINO ACIDS FOR 1EII_A_RTLA135

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwu ENOYL ACP REDUCTASE

(Brassica napus) 		PF13561
(adh_short_C2) 		5 ALA A 272
ILE A 226
LEU A 133
LEU A 186
LEU A  40
 None
None
None
NAD  A 501 (-3.6A)
None
 1.23A 1eiiA-1cwuA:
0.0		 1eiiA-1cwuA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE

(Escherichia
coli) 		PF01634
(HisG)
PF08029
(HisG_C) 		5 THR A 129
ILE A 196
LEU A 106
ARG A 137
LEU A  82
 None
 1.22A 1eiiA-1h3dA:
0.0		 1eiiA-1h3dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		5 ALA A 249
ILE A 309
ARG A 256
LEU A 269
LEU A 227
 None
None
A  B  36 ( 3.7A)
None
None
 0.94A 1eiiA-1h3eA:
0.0		 1eiiA-1h3eA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 5 ALA A 146
ILE A 205
THR A 258
LEU A 183
LEU A  84
 None
 1.32A 1eiiA-1onsA:
0.0		 1eiiA-1onsA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otw COENZYME PQQ
SYNTHESIS PROTEIN C

(Klebsiella
pneumoniae) 		PF03070
(TENA_THI-4) 		5 THR A 146
ALA A 150
ILE A  43
PHE A 149
LEU A 218
 PQQ  A 500 (-3.7A)
PEO  A 600 (-3.1A)
None
None
None
 1.23A 1eiiA-1otwA:
undetectable		 1eiiA-1otwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 ALA A 377
ILE A 423
LEU A 481
LEU A 383
LEU A 510
 None
 1.41A 1eiiA-1oywA:
0.0		 1eiiA-1oywA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 ALA A 377
ILE A 423
PHE A 374
LEU A 481
LEU A 510
 None
 1.31A 1eiiA-1oywA:
0.0		 1eiiA-1oywA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		5 THR A 110
ILE A   5
THR A 165
LEU A 117
LEU A 142
 FMT  A3010 (-2.7A)
None
None
None
None
 1.07A 1eiiA-1r4pA:
0.0		 1eiiA-1r4pA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfl PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Escherichia
coli) 		PF01926
(MMR_HSR1) 		5 ALA A  87
ARG A  89
LEU A  24
LEU A 163
LEU A  46
 None
 1.30A 1eiiA-1rflA:
0.0		 1eiiA-1rflA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00378
(ECH_1) 		5 THR A 150
ILE A  38
LEU A  36
LEU A 114
LEU A 100
 None
 1.35A 1eiiA-1sg4A:
0.0		 1eiiA-1sg4A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		5 ALA A 129
ILE A 118
PHE A 326
LEU A 120
LEU A  95
 None
 1.40A 1eiiA-1vgpA:
0.0		 1eiiA-1vgpA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wym TRANSGELIN-2

(Homo sapiens) 		PF00307
(CH) 		5 ALA A 130
ILE A 102
THR A 120
LEU A 121
LEU A  61
 None
 1.35A 1eiiA-1wymA:
undetectable		 1eiiA-1wymA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Mus musculus) 		PF00005
(ABC_tran)
PF14396
(CFTR_R) 		5 MET A 645
ILE A 661
THR A 665
LEU A 666
LEU A 610
 None
 1.33A 1eiiA-1xfaA:
undetectable		 1eiiA-1xfaA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		5 ALA A  39
PHE A  40
ARG A  42
LEU A 121
LEU A  96
 None
 1.08A 1eiiA-1xkdA:
undetectable		 1eiiA-1xkdA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yac YCAC GENE PRODUCT

(Escherichia
coli) 		PF00857
(Isochorismatase) 		5 ALA A  13
ILE A  82
THR A  57
LEU A  56
LEU A  43
 None
 1.41A 1eiiA-1yacA:
undetectable		 1eiiA-1yacA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC

(Homo sapiens) 		PF01063
(Aminotran_4) 		5 ALA A 163
PHE A 164
LEU A 108
LEU A 135
LEU A 185
 None
 0.99A 1eiiA-2abjA:
undetectable		 1eiiA-2abjA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 687
ILE A 899
THR A 877
LEU A 880
LEU A 700
 None
None
BHM  A   1 (-3.0A)
None
None
 1.37A 1eiiA-2ax9A:
undetectable		 1eiiA-2ax9A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 LYS A 187
ILE A 231
THR A 226
ARG A 288
ARG A 293
 FAD  A2001 (-2.8A)
None
FAD  A2001 (-3.6A)
None
FAD  A2001 (-3.8A)
 1.15A 1eiiA-2g37A:
undetectable		 1eiiA-2g37A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 ALA A 519
ILE A 446
ARG A 531
LEU A 472
LEU A 512
 None
 1.37A 1eiiA-2g3nA:
undetectable		 1eiiA-2g3nA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		5 THR A  91
ALA A  72
ILE A  63
LEU A 117
LEU A  97
 None
 1.13A 1eiiA-2hf8A:
undetectable		 1eiiA-2hf8A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		5 ALA A 239
THR A  50
LEU A 230
LEU A  22
LEU A  81
 None
 1.16A 1eiiA-2ivdA:
undetectable		 1eiiA-2ivdA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kt2 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF00403
(HMA) 		5 THR A  48
ALA A  52
LYS A  63
THR A   7
LEU A  42
 None
 1.21A 1eiiA-2kt2A:
undetectable		 1eiiA-2kt2A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8b PROTEIN TRAI

(Escherichia
coli) 		no annotation 5 ILE A 466
THR A 518
ARG A 527
LEU A 519
LEU A 433
 None
 1.21A 1eiiA-2l8bA:
undetectable		 1eiiA-2l8bA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		5 THR C 245
ALA C 243
LEU C  89
LEU C  96
LEU C 253
 None
 1.29A 1eiiA-2nn3C:
undetectable		 1eiiA-2nn3C:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		5 ALA A 160
ILE A 169
THR A 315
LEU A 262
LEU A 186
 None
 1.37A 1eiiA-2obmA:
undetectable		 1eiiA-2obmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ALA B 625
ARG B 577
LEU B 506
LEU B 515
LEU B 689
 None
 1.41A 1eiiA-2rhqB:
undetectable		 1eiiA-2rhqB:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		5 MET A  20
ILE A 290
PHE A  55
LEU A   8
LEU A 183
 None
 1.06A 1eiiA-2uutA:
undetectable		 1eiiA-2uutA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkt CTP SYNTHASE 2

(Homo sapiens) 		PF00117
(GATase) 		5 ALA A 410
ILE A 375
THR A 378
PHE A 409
LEU A 379
 None
 1.22A 1eiiA-2vktA:
undetectable		 1eiiA-2vktA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		5 MET A 154
THR A 171
ALA A 143
ILE A 118
THR A 114
 None
 1.28A 1eiiA-3eegA:
undetectable		 1eiiA-3eegA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		5 ILE A 141
THR A 135
PHE A 215
LEU A 132
LEU A 166
 None
 1.22A 1eiiA-3ehmA:
undetectable		 1eiiA-3ehmA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ing HOMOSERINE
DEHYDROGENASE

(Thermoplasma
acidophilum) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 ALA A 142
ILE A   7
PHE A 151
LEU A 101
LEU A 120
 NDP  A 326 (-4.8A)
None
None
None
None
 1.37A 1eiiA-3ingA:
undetectable		 1eiiA-3ingA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 THR E 410
ALA E 413
LEU E 247
LEU E 384
LEU E 447
 None
 1.18A 1eiiA-3kfuE:
undetectable		 1eiiA-3kfuE:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Thermoanaerobacter
pseudethanolicus) 		PF00724
(Oxidored_FMN) 		5 THR A  45
ALA A  47
ILE A  74
THR A  59
LEU A  72
 None
 1.37A 1eiiA-3krzA:
undetectable		 1eiiA-3krzA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l84 TRANSKETOLASE

(Campylobacter
jejuni) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 THR A 240
ALA A 238
ILE A 146
LEU A  61
LEU A 224
 None
 1.15A 1eiiA-3l84A:
undetectable		 1eiiA-3l84A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l84 TRANSKETOLASE

(Campylobacter
jejuni) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 THR A 240
ILE A 146
LEU A  61
LEU A  35
LEU A 224
 None
 1.06A 1eiiA-3l84A:
undetectable		 1eiiA-3l84A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m51 14-3-3-LIKE PROTEIN
C

(Nicotiana
tabacum) 		PF00244
(14-3-3) 		5 THR A 167
ALA A 165
THR A 154
LEU A 155
LEU A 200
 None
 1.13A 1eiiA-3m51A:
undetectable		 1eiiA-3m51A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 THR B 536
ARG B 343
LEU B 375
LEU B 408
LEU B 230
 None
CL  B1131 (-3.8A)
None
None
None
 1.25A 1eiiA-3p8cB:
undetectable		 1eiiA-3p8cB:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sll PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 ALA A 121
ILE A  13
LEU A  15
LEU A  18
LEU A 194
 None
 1.31A 1eiiA-3sllA:
undetectable		 1eiiA-3sllA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slu M23 PEPTIDASE DOMAIN
PROTEIN

(Neisseria
meningitidis) 		PF01551
(Peptidase_M23) 		5 ALA A 302
ILE A 331
THR A 339
LEU A 340
LEU A 344
 None
 1.20A 1eiiA-3sluA:
undetectable		 1eiiA-3sluA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 MET A 323
ALA A 403
ILE A 505
LEU A 396
LEU A 389
 None
 1.23A 1eiiA-3tchA:
undetectable		 1eiiA-3tchA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 ALA A 245
ILE A 715
THR A 692
PHE A 554
LEU A 426
 None
 1.33A 1eiiA-3ue1A:
undetectable		 1eiiA-3ue1A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		5 THR A 120
ALA A 118
ILE A 208
LEU A 362
LEU A 165
 None
None
None
HEM  A 501 ( 4.4A)
None
 1.36A 1eiiA-3wecA:
undetectable		 1eiiA-3wecA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 THR A 119
ALA A 115
THR A  47
LEU A  96
LEU A  57
 None
 1.16A 1eiiA-3wkyA:
undetectable		 1eiiA-3wkyA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am6 ACTIN-LIKE PROTEIN
ARP8

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 THR A 717
ALA A 714
ILE A 503
THR A 508
LEU A 526
 None
 1.34A 1eiiA-4am6A:
undetectable		 1eiiA-4am6A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 PHE A 328
ARG A 331
LEU A 389
LEU A 352
LEU A 220
 None
 1.28A 1eiiA-4b56A:
1.0		 1eiiA-4b56A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 157
ILE A 120
THR A 288
LEU A 287
LEU A 160
 None
 1.36A 1eiiA-4bgqA:
undetectable		 1eiiA-4bgqA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 THR A 532
ALA A 506
LYS A 726
LEU A 393
LEU A 586
 None
 1.38A 1eiiA-4cakA:
undetectable		 1eiiA-4cakA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		5 ALA A  37
ILE A  60
THR A  89
LEU A 125
LEU A 276
 None
 1.29A 1eiiA-4d1iA:
undetectable		 1eiiA-4d1iA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus) 		PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel) 		5 MET A 405
THR A 369
ALA A 373
ILE A 409
LEU A 397
 None
 1.19A 1eiiA-4d2iA:
undetectable		 1eiiA-4d2iA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djb E4-ORF3

(Human
mastadenovirus
C) 		PF06931
(Adeno_E4_ORF3) 		5 THR A  96
ALA A  20
ILE A  51
LEU A  28
LEU A  13
 None
 1.34A 1eiiA-4djbA:
undetectable		 1eiiA-4djbA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0e POLY [ADP-RIBOSE]
POLYMERASE 15

(Homo sapiens) 		PF00644
(PARP) 		5 MET A 593
ALA A 571
ILE A 503
PHE A 638
ARG A 533
 None
 1.15A 1eiiA-4f0eA:
undetectable		 1eiiA-4f0eA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2n SUPEROXIDE DISMUTASE

(Leishmania
major) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 THR A  90
ALA A  88
LEU A  29
LEU A 180
LEU A  70
 None
 1.31A 1eiiA-4f2nA:
undetectable		 1eiiA-4f2nA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f48 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF00563
(EAL) 		5 MET A 108
PHE A  21
LEU A  82
LEU A  23
LEU A 128
 None
 1.41A 1eiiA-4f48A:
undetectable		 1eiiA-4f48A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhy HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis) 		PF14730
(DUF4468) 		5 ALA A 137
ILE A 115
PHE A 159
LEU A 170
LEU A  90
 None
 1.38A 1eiiA-4jhyA:
undetectable		 1eiiA-4jhyA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jot ENOYL-COA HYDRATASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF00378
(ECH_1) 		5 MET A 107
THR A   9
ALA A  25
LEU A 124
LEU A  48
 None
 1.18A 1eiiA-4jotA:
undetectable		 1eiiA-4jotA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldz TRANSCRIPTIONAL
REGULATORY PROTEIN
DESR

(Bacillus
subtilis) 		PF00072
(Response_reg)
PF00196
(GerE) 		5 THR A 139
ILE A  78
THR A  80
LEU A 101
LEU A 131
 None
None
BEF  A 202 (-3.7A)
None
None
 1.22A 1eiiA-4ldzA:
undetectable		 1eiiA-4ldzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 ALA A 342
ILE A 171
THR A 199
PHE A 379
LEU A 104
 None
 1.34A 1eiiA-4lihA:
undetectable		 1eiiA-4lihA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n30 PROTEIN DISULFIDE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13462
(Thioredoxin_4) 		5 THR A 193
THR A 185
ARG A 195
LEU A 186
LEU A 215
 None
 1.41A 1eiiA-4n30A:
undetectable		 1eiiA-4n30A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		5 ALA A 117
ILE A 166
THR A 159
LEU A 100
LEU A 310
 None
 1.20A 1eiiA-4oanA:
undetectable		 1eiiA-4oanA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens) 		PF08389
(Xpo1) 		5 THR B 784
ALA B 782
LEU B 767
LEU B 799
LEU B 752
 None
 1.36A 1eiiA-4ol0B:
undetectable		 1eiiA-4ol0B:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 524
ARG A 511
LEU A 691
LEU A 466
LEU A 493
 None
 1.33A 1eiiA-4oqjA:
undetectable		 1eiiA-4oqjA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcv BDCA (YJGI)

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 ALA A 113
ILE A  85
ARG A  63
LEU A 102
LEU A 153
 None
 1.30A 1eiiA-4pcvA:
undetectable		 1eiiA-4pcvA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A  39
ILE A 111
LEU A  62
LEU A  55
LEU A  32
 None
 1.25A 1eiiA-4plsA:
undetectable		 1eiiA-4plsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A  81
ILE A 153
LEU A 104
LEU A  97
LEU A  74
 None
 1.16A 1eiiA-4plsA:
undetectable		 1eiiA-4plsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A 123
ILE A 195
LEU A 146
LEU A 139
LEU A 116
 None
 1.40A 1eiiA-4plsA:
undetectable		 1eiiA-4plsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A 165
ILE A 237
LEU A 188
LEU A 181
LEU A 158
 None
 1.32A 1eiiA-4plsA:
undetectable		 1eiiA-4plsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 THR A 668
ALA A 747
ILE A 680
LEU B 928
ARG B 958
 None
 1.37A 1eiiA-4qiwA:
undetectable		 1eiiA-4qiwA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		5 MET A 146
ALA A 182
THR A 287
LEU A 272
LEU A 190
 None
 1.10A 1eiiA-4rgqA:
undetectable		 1eiiA-4rgqA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnw AVERMECTIN-SENSITIVE
GLUTAMATE-GATED
CHLORIDE CHANNEL
GLUCL ALPHA

(Caenorhabditis
elegans) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 THR A  90
ALA A 149
LEU A  36
LEU A  55
LEU A 128
 None
 1.37A 1eiiA-4tnwA:
undetectable		 1eiiA-4tnwA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD

(Mycolicibacterium
smegmatis) 		PF10017
(Methyltransf_33) 		5 ALA A  77
ILE A 164
LEU A  85
LEU A  82
LEU A 183
 None
 1.10A 1eiiA-4uy6A:
undetectable		 1eiiA-4uy6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3q YIII_M4_AII

(synthetic
construct) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ALA A  81
ILE A 153
LEU A 104
LEU A  97
LEU A  74
 None
 1.29A 1eiiA-4v3qA:
undetectable		 1eiiA-4v3qA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3q YIII_M4_AII

(synthetic
construct) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ALA A 165
ILE A 237
LEU A 188
LEU A 181
LEU A 158
 None
 1.38A 1eiiA-4v3qA:
undetectable		 1eiiA-4v3qA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh0 PUTATIVE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		5 ALA A  13
ILE A  82
THR A  57
LEU A  56
LEU A  43
 None
 1.34A 1eiiA-4wh0A:
undetectable		 1eiiA-4wh0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 MET A 536
ALA A 509
ILE A 744
ARG A 483
LEU A 498
 None
 1.11A 1eiiA-4xhjA:
undetectable		 1eiiA-4xhjA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01008
(IF-2B)
PF01008
(IF-2B) 		5 ALA C 299
ARG G 438
LEU G 341
LEU G 439
LEU G 329
 None
 1.37A 1eiiA-5b04C:
undetectable		 1eiiA-5b04C:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		5 MET A 212
ALA A  78
THR A 364
ARG A  41
LEU A  31
 None
 1.31A 1eiiA-5c2iA:
undetectable		 1eiiA-5c2iA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyu CONSERVED MEMBRANE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF05108
(T7SS_ESX1_EccB) 		5 ALA A 225
THR A 294
ARG A 213
LEU A 330
LEU A 199
 None
 1.17A 1eiiA-5cyuA:
undetectable		 1eiiA-5cyuA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 5 THR B 819
ALA B 816
ILE B 914
LEU B 921
LEU B 835
 None
 1.24A 1eiiA-5dlqB:
undetectable		 1eiiA-5dlqB:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE

(Chromohalobacter
salexigens) 		PF00120
(Gln-synt_C) 		5 ALA A 365
ILE A 216
PHE A 305
ARG A 121
LEU A 222
 None
 1.38A 1eiiA-5dm3A:
undetectable		 1eiiA-5dm3A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ALA A 325
PHE A 275
ARG A 278
LEU A 336
LEU A 167
 None
 1.16A 1eiiA-5gz4A:
0.9		 1eiiA-5gz4A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ALA A 325
PHE A 275
LEU A 336
LEU A 299
LEU A 167
 None
 1.13A 1eiiA-5gz4A:
0.9		 1eiiA-5gz4A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd0 ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00620
(RhoGAP) 		5 ILE A 919
THR A1030
ARG A 995
LEU A1031
LEU A 996
 None
 1.35A 1eiiA-5jd0A:
undetectable		 1eiiA-5jd0A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvo ARGININE REPRESSOR

(Corynebacterium
pseudotuberculosis) 		PF02863
(Arg_repressor_C) 		5 THR A 109
PHE A 155
ARG A 159
LEU A  94
LEU A  87
 None
 1.27A 1eiiA-5jvoA:
undetectable		 1eiiA-5jvoA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k50 L-THREONINE
3-DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 5 MET A1217
ALA A1021
THR A1179
LEU A1045
LEU A1077
 None
None
None
None
NAD  A1401 (-4.3A)
 1.35A 1eiiA-5k50A:
undetectable		 1eiiA-5k50A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT

(Lactococcus
lactis;
Lactococcus
lactis) 		PF01180
(DHO_dh)
PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		5 ALA B 233
THR A 198
LEU A 220
LEU B  51
LEU A 213
 FES  B 302 ( 4.3A)
FMN  A 401 ( 4.7A)
None
FAD  B 301 ( 4.2A)
None
 1.17A 1eiiA-5kswB:
undetectable		 1eiiA-5kswB:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfd YIIIM''6AII

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A 123
ILE A 195
LEU A 146
LEU A 139
LEU A 116
 None
 1.37A 1eiiA-5mfdA:
undetectable		 1eiiA-5mfdA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfd YIIIM''6AII

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A 165
ILE A 237
LEU A 188
LEU A 181
LEU A 158
 None
 1.28A 1eiiA-5mfdA:
undetectable		 1eiiA-5mfdA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfo YIIIM3AIII

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A  39
ILE A 111
LEU A  62
LEU A  55
LEU A  32
 None
 1.27A 1eiiA-5mfoA:
undetectable		 1eiiA-5mfoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfo YIIIM3AIII

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A  81
ILE A 153
LEU A 104
LEU A  97
LEU A  74
 None
 1.34A 1eiiA-5mfoA:
undetectable		 1eiiA-5mfoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		5 THR A 130
ALA A 134
ARG A 228
LEU A 189
LEU A 224
 None
 1.16A 1eiiA-5mscA:
undetectable		 1eiiA-5mscA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 5 THR B 214
ALA B 182
THR B 208
LEU B 134
LEU B 146
 None
 1.34A 1eiiA-5swiB:
1.0		 1eiiA-5swiB:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umf RIBULOSE-PHOSPHATE
3-EPIMERASE

(Neisseria
gonorrhoeae) 		PF00834
(Ribul_P_3_epim) 		5 ALA A  85
ILE A 175
PHE A  35
LEU A 114
LEU A  68
 None
 1.20A 1eiiA-5umfA:
undetectable		 1eiiA-5umfA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf4 UNCHARACTERIZED
PROTEIN

(Thermus
aquaticus) 		PF03781
(FGE-sulfatase) 		5 ALA A 297
THR A 279
LEU A 253
LEU A 207
LEU A 304
 None
 1.31A 1eiiA-5vf4A:
undetectable		 1eiiA-5vf4A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xaw SODIUM CHANNEL
SUBUNIT BETA-4

(Homo sapiens) 		PF07686
(V-set) 		5 ALA A  75
PHE A  76
LEU A 121
LEU A  79
ARG A 100
 PG4  A 202 ( 4.5A)
P33  A 201 ( 4.9A)
None
None
PG4  A 202 (-4.0A)
 1.38A 1eiiA-5xawA:
undetectable		 1eiiA-5xawA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 THR A 292
ALA A 344
THR A 445
LEU A  96
LEU A 399
 None
 1.39A 1eiiA-5xh9A:
undetectable		 1eiiA-5xh9A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0m -

(-) 		no annotation 5 ALA A  81
ILE A 269
THR A 309
LEU A 310
LEU A 283
 None
 1.32A 1eiiA-5y0mA:
undetectable		 1eiiA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bma INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Campylobacter
jejuni) 		no annotation 5 ALA A  85
ILE A  67
LEU A  91
LEU A 115
LEU A 239
 None
 1.20A 1eiiA-6bmaA:
undetectable		 1eiiA-6bmaA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 5 ALA A 298
ILE A 266
ARG A 283
LEU A 341
LEU A 287
 None
 1.39A 1eiiA-6d46A:
undetectable		 1eiiA-6d46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis) 		no annotation 5 MET A  15
ALA A  33
PHE A  52
LEU A  72
LEU A  26
 None
 1.39A 1eiiA-6f2cA:
undetectable		 1eiiA-6f2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 5 THR A 196
ALA A 200
ILE A 619
LEU A 621
LEU A 703
 None
None
None
HEM  A1001 (-4.8A)
None
 1.25A 1eiiA-6fwfA:
undetectable		 1eiiA-6fwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 GLN A 252
THR A 213
SER A 247
GLN A 207
 None
 1.43A 1eiiA-1ahiA:
0.0		 1eiiA-1ahiA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cl7 PROTEIN (IGG1
ANTIBODY 1696
(VARIABLE HEAVY
CHAIN))

(Mus musculus) 		PF07686
(V-set) 		4 GLN H   6
THR H 107
SER H   7
TYR H  90
 None
 1.35A 1eiiA-1cl7H:
0.0		 1eiiA-1cl7H:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 TYR A  89
GLN A 197
SER A 239
TYR A 243
 DCA  A 801 (-4.0A)
None
DCA  A 801 ( 4.1A)
B12  A 800 ( 4.6A)
 1.32A 1eiiA-1e1cA:
0.0		 1eiiA-1e1cA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 GLN P 476
SER P 475
TRP P 124
GLN P 139
 None
 1.33A 1eiiA-1e33P:
0.0		 1eiiA-1e33P:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2d TATA BOX ZINC FINGER
PROTEIN

(Mus musculus) 		PF00096
(zf-C2H2)
PF13894
(zf-C2H2_4) 		4 GLN C 146
THR C 124
SER C 145
GLN C 118
 None
 1.35A 1eiiA-1g2dC:
undetectable		 1eiiA-1g2dC:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		4 THR A  53
SER A  55
TYR A  60
TRP A 106
 None
 0.79A 1eiiA-1gglA:
7.3		 1eiiA-1gglA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxm GAMMA-DELTA T-CELL
RECEPTOR

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN B   8
THR B 117
SER B  11
TYR B  95
 None
 1.43A 1eiiA-1hxmB:
undetectable		 1eiiA-1hxmB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j05 ANTI-CEA MAB T84.66,
HEAVY CHAIN
ANTI-CEA MAB T84.66,
LIGHT CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 GLN H   6
SER H   7
TYR H  90
GLN L  38
 None
 1.48A 1eiiA-1j05H:
0.0		 1eiiA-1j05H:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		5 GLN A  38
THR A  53
SER A  55
TRP A 106
GLN A 108
 None
 1.09A 1eiiA-1kqxA:
8.0		 1eiiA-1kqxA:
73.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 GLN A 404
SER A 405
TYR A 583
GLN A 431
 None
 1.33A 1eiiA-1nl3A:
undetectable		 1eiiA-1nl3A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 TYR Q  97
GLN Q 398
THR Q 376
GLN Q 360
 None
 1.16A 1eiiA-1oh2Q:
1.8		 1eiiA-1oh2Q:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 TYR Q  97
THR Q 376
SER Q 396
GLN Q 360
 None
 1.43A 1eiiA-1oh2Q:
1.8		 1eiiA-1oh2Q:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 TYR Q 213
THR Q 248
TYR Q 228
GLN Q 257
 None
 1.39A 1eiiA-1oh2Q:
1.8		 1eiiA-1oh2Q:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 TYR A 438
THR A 335
SER A 312
TRP A 560
 None
CA  A 602 (-4.3A)
None
None
 1.47A 1eiiA-1ot5A:
undetectable		 1eiiA-1ot5A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 TYR A  42
SER A 397
TYR A  76
TRP A 138
 None
 1.32A 1eiiA-1pw4A:
undetectable		 1eiiA-1pw4A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 TYR B 348
GLN B 379
SER B 748
GLN B 419
 None
 1.50A 1eiiA-1t3qB:
undetectable		 1eiiA-1t3qB:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE

(Clostridium
perfringens) 		PF00722
(Glyco_hydro_16) 		4 TYR A 335
GLN A 195
THR A 199
SER A 197
 None
 1.11A 1eiiA-1upsA:
undetectable		 1eiiA-1upsA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xio ANABAENA SENSORY
RHODOPSIN

(Nostoc sp. PCC
7120) 		PF01036
(Bac_rhodopsin) 		4 GLN A 157
THR A 154
SER A 158
TYR A 165
 None
 1.18A 1eiiA-1xioA:
undetectable		 1eiiA-1xioA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqm KINDLING FLUORESCENT
PROTEIN

(Anemonia
sulcata) 		PF01353
(GFP) 		4 TYR A  72
SER A  83
TYR A 178
GLN A  39
 None
None
None
CH6  A  63 ( 3.5A)
 1.22A 1eiiA-1xqmA:
undetectable		 1eiiA-1xqmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypz T CELL RECEPTOR
DELTA

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN E   6
THR E 112
SER E   7
TYR E  86
 None
 1.39A 1eiiA-1ypzE:
undetectable		 1eiiA-1ypzE:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 4 TYR P 271
THR P 309
SER P 306
TRP P 278
 None
 1.41A 1eiiA-2btvP:
undetectable		 1eiiA-2btvP:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 TYR A 155
THR A 106
TYR A 108
TRP A 171
 None
 1.44A 1eiiA-2esnA:
undetectable		 1eiiA-2esnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		4 GLN A  60
THR A  71
TYR A  68
GLN A 100
 None
None
PE4  A4124 (-3.8A)
FMN  A4401 (-3.0A)
 1.22A 1eiiA-2gouA:
undetectable		 1eiiA-2gouA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 GLN A 156
THR A  18
SER A  22
GLN A 275
 None
 1.47A 1eiiA-2l7bA:
undetectable		 1eiiA-2l7bA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C

(Neurospora
crassa) 		PF00225
(Kinesin) 		4 GLN A 145
THR A 400
SER A 393
TYR A 397
 None
 1.40A 1eiiA-2owmA:
undetectable		 1eiiA-2owmA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 TYR A  89
GLN A 161
THR A 165
GLN A 400
 None
 1.45A 1eiiA-2po4A:
undetectable		 1eiiA-2po4A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 TYR A 868
TYR A 857
TRP A 860
GLN A 905
 None
 1.40A 1eiiA-2qepA:
0.7		 1eiiA-2qepA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE

(Escherichia
coli) 		PF02618
(YceG) 		4 TYR A 142
THR A 286
SER A 213
GLN A 126
 None
 1.38A 1eiiA-2r1fA:
undetectable		 1eiiA-2r1fA:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 GLN A  38
THR A  53
SER A  55
TRP A 106
GLN A 108
 None
 1.17A 1eiiA-2rcqA:
8.0		 1eiiA-2rcqA:
88.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
GLN A  38
TRP A 106
GLN A 108
 None
 1.14A 1eiiA-2rcqA:
8.0		 1eiiA-2rcqA:
88.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato bushy
stunt virus) 		PF00729
(Viral_coat) 		4 TYR A 155
THR A 228
SER A 226
GLN A 133
 None
 1.40A 1eiiA-2tbvA:
undetectable		 1eiiA-2tbvA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLN B 234
THR B 339
SER B 337
GLN B 197
 None
None
None
XAX  B1778 (-3.5A)
 1.32A 1eiiA-2w55B:
undetectable		 1eiiA-2w55B:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xiv HYPOTHETICAL
INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 THR A 463
SER A 414
TRP A 267
GLN A 431
 None
 1.41A 1eiiA-2xivA:
undetectable		 1eiiA-2xivA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		4 TYR A  88
GLN A 159
SER A 158
GLN A 173
 None
 1.41A 1eiiA-2xmzA:
undetectable		 1eiiA-2xmzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		4 GLN A 180
THR A 156
SER A 154
TRP A 172
 None
 1.35A 1eiiA-2ybqA:
undetectable		 1eiiA-2ybqA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apm PROTEIN-ARGININE
DEIMINASE TYPE-4

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 GLN A 286
THR A 268
SER A 270
GLN A 136
 None
 1.45A 1eiiA-3apmA:
undetectable		 1eiiA-3apmA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bew MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
GLYCOPROTEIN
HAPLOTYPE B21

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 156
SER A  69
TYR A   7
TRP A 164
 None
 1.14A 1eiiA-3bewA:
undetectable		 1eiiA-3bewA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc7 PUTATIVE
UNCHARACTERIZED
PROTEIN LP_3323

(Lactobacillus
plantarum) 		PF13472
(Lipase_GDSL_2) 		4 GLN A  99
THR A  64
SER A  67
TYR A  69
 None
 1.28A 1eiiA-3dc7A:
undetectable		 1eiiA-3dc7A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C)
PF02665
(Nitrate_red_gam) 		4 TYR B 100
THR B 225
TYR B  62
GLN C  41
 None
None
None
HEM  C 806 (-4.5A)
 1.41A 1eiiA-3egwB:
undetectable		 1eiiA-3egwB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esu ANTIBODY 14B7* LIGHT
CHAIN AND ANTIBODY
14B7* HEAVY CHAIN
LINKED WITH A
SYNTHETIC (GGGGS)4
LINKER

(Mus musculus) 		PF07686
(V-set) 		4 GLN F1006
SER F1007
TYR F1090
GLN F  38
 None
 1.49A 1eiiA-3esuF:
undetectable		 1eiiA-3esuF:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 GLN C 174
THR C 352
SER C 172
GLN C 241
 None
 1.32A 1eiiA-3gzdC:
undetectable		 1eiiA-3gzdC:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0z PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Streptococcus
pneumoniae) 		PF01380
(SIS) 		4 GLN A 166
THR A 187
SER A 183
TYR A  35
 None
 1.37A 1eiiA-3i0zA:
undetectable		 1eiiA-3i0zA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLN A 311
THR A 314
SER A 302
TYR A 300
 None
 1.29A 1eiiA-3iplA:
undetectable		 1eiiA-3iplA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC

(Escherichia
coli) 		no annotation 4 TYR A 374
THR A 229
SER A 449
GLN A 303
 None
 1.15A 1eiiA-3ly9A:
undetectable		 1eiiA-3ly9A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		4 TYR A 110
THR A  87
SER A 120
TYR A 118
 None
 1.29A 1eiiA-3q6tA:
0.9		 1eiiA-3q6tA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qg7 AP4-24H11 ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN H  81
THR H  70
SER H  68
GLN H  77
 None
None
P6G  H 229 (-4.2A)
None
 1.44A 1eiiA-3qg7H:
undetectable		 1eiiA-3qg7H:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwb PROBABLE QUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TYR A 307
THR A 324
SER A 321
GLN A 132
 None
None
None
NDP  A 335 (-3.6A)
 1.38A 1eiiA-3qwbA:
undetectable		 1eiiA-3qwbA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6d PUTATIVE
TRIOSEPHOSPHATE
ISOMERASE

(Coccidioides
immitis) 		PF00121
(TIM) 		4 THR A  31
SER A  29
TYR A  34
GLN A  96
 None
 1.02A 1eiiA-3s6dA:
undetectable		 1eiiA-3s6dA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 GLN A 215
SER A 213
TYR A 147
GLN A  88
 None
 1.29A 1eiiA-3tlkA:
undetectable		 1eiiA-3tlkA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		4 THR A 353
SER A 428
TYR A 223
GLN A 357
 None
 1.36A 1eiiA-3vtaA:
undetectable		 1eiiA-3vtaA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 TYR A 236
GLN A 485
SER A 509
TRP A 351
 None
 1.32A 1eiiA-3w6qA:
undetectable		 1eiiA-3w6qA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buh CLONE M0418 SCFV

(Homo sapiens) 		PF07686
(V-set) 		4 GLN A   6
SER A   7
TYR A  94
GLN A 180
 None
 1.45A 1eiiA-4buhA:
undetectable		 1eiiA-4buhA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		4 THR A 246
TYR A 248
TRP A 225
GLN A 262
 None
 1.36A 1eiiA-4ci8A:
undetectable		 1eiiA-4ci8A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxo LEA X(6) GFP-LIKE
PROTEINS

(synthetic
construct) 		PF01353
(GFP) 		4 TYR A  71
SER A  82
TYR A 177
GLN A  38
 None
None
None
CR8  A  63 ( 3.7A)
 1.48A 1eiiA-4dxoA:
undetectable		 1eiiA-4dxoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		4 TYR A 308
GLN A 396
THR A 359
SER A 263
 None
 1.44A 1eiiA-4f7aA:
undetectable		 1eiiA-4f7aA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963

(Streptomyces
coelicolor) 		no annotation 4 GLN B  95
THR B 151
SER B 149
TRP B 393
 None
 1.05A 1eiiA-4gt2B:
undetectable		 1eiiA-4gt2B:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuz ANTIBODY 4A5 HEAVY
CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN H   6
THR H 114
SER H   7
TYR H  94
 None
 1.31A 1eiiA-4kuzH:
undetectable		 1eiiA-4kuzH:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 GLN A  59
THR A 314
TYR A 315
GLN A 343
 None
 1.41A 1eiiA-4lvqA:
undetectable		 1eiiA-4lvqA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		PF09084
(NMT1) 		4 GLN A 249
THR A  19
SER A 229
TYR A 219
 None
 1.40A 1eiiA-4nmyA:
undetectable		 1eiiA-4nmyA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 TYR A 844
GLN A 820
THR A 840
TRP A 843
 None
 1.40A 1eiiA-4o9xA:
undetectable		 1eiiA-4o9xA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 SER A 404
TYR A 380
TRP A 371
GLN A 417
 None
 1.33A 1eiiA-4pvgA:
1.1		 1eiiA-4pvgA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql0 FILAMENTOUS
HEMAGGLUTININ
TRANSPORTER PROTEIN
FHAC

(Bordetella
pertussis) 		PF03865
(ShlB)
PF08479
(POTRA_2)
PF17287
(POTRA_3) 		4 TYR A 447
THR A 527
SER A 529
TYR A 547
 None
 1.19A 1eiiA-4ql0A:
1.5		 1eiiA-4ql0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qre METHIONYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 TYR A 123
THR A 133
SER A 128
TRP A 237
 None
3BG  A 601 (-3.7A)
None
None
 1.41A 1eiiA-4qreA:
undetectable		 1eiiA-4qreA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
HEAVY CHAIN
HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 GLN H   6
SER H   7
TYR H  90
GLN L  38
 None
 1.48A 1eiiA-4rqqH:
undetectable		 1eiiA-4rqqH:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tl3 ANABAENA SENSORY
RHODOPSIN

(Nostoc sp. PCC
7120) 		PF01036
(Bac_rhodopsin) 		4 GLN A 157
THR A 154
SER A 158
TYR A 165
 None
 1.20A 1eiiA-4tl3A:
undetectable		 1eiiA-4tl3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 THR A 137
SER A 185
TYR A 183
TRP A 149
 None
 1.36A 1eiiA-4uaqA:
undetectable		 1eiiA-4uaqA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 GLN A 138
THR A 137
TRP A 621
GLN A 645
 None
 1.49A 1eiiA-4xwhA:
undetectable		 1eiiA-4xwhA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a20 MAJOR TAIL PROTEIN
GP17.1

(Bacillus phage
SPP1) 		PF06199
(Phage_tail_2) 		4 TYR H 104
GLN H  16
THR H  22
GLN H  32
 None
 1.20A 1eiiA-5a20H:
undetectable		 1eiiA-5a20H:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 TYR A 752
GLN A 693
SER A 692
GLN A1065
 U  C   5 ( 4.1A)
U  C   5 ( 3.0A)
U  C   7 ( 2.5A)
None
 1.28A 1eiiA-5aorA:
undetectable		 1eiiA-5aorA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epd GLYCEROL TRINITRATE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		4 GLN A  60
THR A  71
TYR A  68
GLN A 100
 None
 1.15A 1eiiA-5epdA:
undetectable		 1eiiA-5epdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 SER A 404
TYR A 380
TRP A 371
GLN A 417
 None
 1.32A 1eiiA-5i6vA:
undetectable		 1eiiA-5i6vA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		4 GLN A 392
THR A 431
TYR A 432
GLN A 362
 None
 1.37A 1eiiA-5j5uA:
undetectable		 1eiiA-5j5uA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1

(Mus musculus) 		PF01094
(ANF_receptor) 		4 THR A 106
SER A 104
TYR A 139
TRP A 359
 None
 1.37A 1eiiA-5kc9A:
0.9		 1eiiA-5kc9A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1x HMPV F1 SUBUNIT

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		4 GLN B 312
THR B 317
TYR B 310
GLN B 346
 None
 1.23A 1eiiA-5l1xB:
undetectable		 1eiiA-5l1xB:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		4 TYR A 175
GLN A  63
TYR A 102
GLN A 212
 None
 1.15A 1eiiA-5ltqA:
undetectable		 1eiiA-5ltqA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans) 		PF04261
(Dyp_perox) 		4 GLN A  95
THR A 151
SER A 149
TRP A 393
 None
 1.04A 1eiiA-5mapA:
undetectable		 1eiiA-5mapA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC

(synthetic
construct) 		no annotation 4 TYR D 260
GLN D  73
TYR D 112
GLN D 297
 None
CR2  D  70 ( 4.9A)
CR2  D  70 ( 4.8A)
None
 1.21A 1eiiA-5mwcD:
undetectable		 1eiiA-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8d FIBER

(Murine
mastadenovirus
B) 		no annotation 4 GLN A 744
THR A 746
TYR A 747
GLN A 683
 None
None
None
GOL  A 801 (-4.0A)
 1.35A 1eiiA-5n8dA:
undetectable		 1eiiA-5n8dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 GLN A  26
TYR A  16
TRP A  49
GLN A  53
 None
 1.42A 1eiiA-5te1A:
undetectable		 1eiiA-5te1A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
pombe) 		no annotation 4 GLN A 215
THR A 214
SER A 216
GLN A 142
 None
 1.46A 1eiiA-5wjcA:
undetectable		 1eiiA-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqw N-ACETYLGLUCOSAMINID
ASE

(Clostridium
perfringens) 		PF01832
(Glucosaminidase) 		4 GLN A1085
SER A1074
TYR A1067
GLN A 892
 None
None
None
EDO  A1201 ( 4.3A)
 1.48A 1eiiA-5wqwA:
undetectable		 1eiiA-5wqwA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 TYR A 186
THR A 115
TYR A 116
GLN A 108
 None
None
GOL  A 402 (-4.5A)
None
 1.49A 1eiiA-5x18A:
undetectable		 1eiiA-5x18A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4t PHOTOACTIVATED
ADENYLYL CYCLASE

(Cyanobacteria) 		PF00211
(Guanylate_cyc)
PF04940
(BLUF) 		4 THR A 330
SER A 334
TRP A 303
GLN A 216
 None
 1.42A 1eiiA-5x4tA:
undetectable		 1eiiA-5x4tA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd2 NUDIX FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF00293
(NUDIX)
PF00300
(His_Phos_1) 		4 GLN A 202
THR A 300
TYR A 315
GLN A 195
 None
None
GOL  A 403 (-4.8A)
None
 1.47A 1eiiA-5xd2A:
undetectable		 1eiiA-5xd2A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 TYR A 737
THR A 724
SER A 693
TYR A 728
 None
 1.35A 1eiiA-5y4fA:
undetectable		 1eiiA-5y4fA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yd5 SCFV 4B08

(Mus musculus) 		no annotation 4 GLN A   8
SER A   9
TYR A  96
GLN A 183
 None
 1.37A 1eiiA-5yd5A:
undetectable		 1eiiA-5yd5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1

(Moorea
bouillonii) 		no annotation 4 GLN A  78
THR A  76
SER A  63
TYR A  66
 None
 1.33A 1eiiA-6b3bA:
undetectable		 1eiiA-6b3bA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejg SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 4 GLN C 175
SER C 176
TYR C 263
GLN C  80
 None
 1.42A 1eiiA-6ejgC:
undetectable		 1eiiA-6ejgC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 4 TYR B 216
THR B  32
SER B 406
TYR B  26
 D5E  B 501 ( 4.5A)
D5E  B 501 (-3.4A)
D5E  B 501 ( 3.4A)
D5E  B 501 (-3.7A)
 1.08A 1eiiA-6fd2B:
undetectable		 1eiiA-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 4 TYR B 123
THR B 365
SER B 116
TYR B 119
 None
 1.48A 1eiiA-6fosB:
undetectable		 1eiiA-6fosB:
undetectable