SIMILAR PATTERNS OF AMINO ACIDS FOR 1EE2_B_CHDB1250_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcn DELTA 2 CRYSTALLIN

(Anas
platyrhynchos)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
3 MET A 252
LEU A 255
SER A 256
None
0.54A 1ee2A-1dcnA:
0.0
1ee2A-1dcnA:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ee2 ALCOHOL
DEHYDROGENASE


(Equus caballus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 MET A 305
LEU A 308
SER A 309
None
0.00A 1ee2A-1ee2A:
71.0
1ee2A-1ee2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezj NUCLEOCAPSID
PHOSPHOPROTEIN


(Murine
respirovirus)
PF01806
(Paramyxo_P)
3 MET A 104
LEU A 107
SER A 108
None
0.61A 1ee2A-1ezjA:
undetectable
1ee2A-1ezjA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbr PROTEIN (HEMOGLOBIN
D)


(Gallus gallus)
PF00042
(Globin)
3 MET A  80
LEU A  83
SER A  84
None
HEM  A 142 (-4.6A)
None
0.54A 1ee2A-1hbrA:
undetectable
1ee2A-1hbrA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR


(Equus caballus)
PF00079
(Serpin)
3 MET A  23
LEU A  26
SER A  27
ACE  A  22 ( 4.2A)
None
None
0.54A 1ee2A-1hleA:
undetectable
1ee2A-1hleA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0a DELTA CRYSTALLIN I

(Meleagris
gallopavo)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
3 MET A 250
LEU A 253
SER A 254
None
0.58A 1ee2A-1i0aA:
0.0
1ee2A-1i0aA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1


(Bacillus
subtilis)
PF00067
(p450)
3 MET A  97
LEU A 100
SER A 101
None
0.56A 1ee2A-1izoA:
undetectable
1ee2A-1izoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK


(Rattus
norvegicus)
PF07714
(Pkinase_Tyr)
3 MET A 712
LEU A 715
SER A 716
None
0.68A 1ee2A-1lufA:
0.0
1ee2A-1lufA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus)
PF00067
(p450)
3 MET A 132
LEU A 135
SER A 136
None
0.57A 1ee2A-1n97A:
0.0
1ee2A-1n97A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE


(Bacillus
subtilis)
PF05448
(AXE1)
3 MET C 242
LEU C 245
SER C 246
None
0.60A 1ee2A-1odtC:
2.5
1ee2A-1odtC:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE


(Escherichia
coli)
PF00311
(PEPcase)
3 MET A 657
LEU A 660
SER A 661
None
0.67A 1ee2A-1qb4A:
0.7
1ee2A-1qb4A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS


(Escherichia
coli)
PF01614
(IclR)
3 MET A  11
LEU A  14
SER A  15
None
0.61A 1ee2A-1tf1A:
undetectable
1ee2A-1tf1A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE


(Escherichia
coli)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
3 MET A 246
LEU A 249
SER A 250
None
0.56A 1ee2A-1tj7A:
undetectable
1ee2A-1tj7A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq8 ALPHA-SYNUCLEIN

(Homo sapiens)
PF01387
(Synuclein)
3 MET A   5
LEU A   8
SER A   9
None
0.68A 1ee2A-1xq8A:
undetectable
1ee2A-1xq8A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852


(Thermoplasma
acidophilum)
PF08704
(GCD14)
3 MET A 132
LEU A 135
SER A 136
None
0.36A 1ee2A-1yb2A:
8.3
1ee2A-1yb2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2i AMMONIUM TRANSPORTER

(Archaeoglobus
fulgidus)
PF00909
(Ammonium_transp)
3 MET A  39
LEU A  42
SER A  43
None
0.68A 1ee2A-2b2iA:
undetectable
1ee2A-2b2iA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnx DIAPHANOUS PROTEIN
HOMOLOG 1


(Mus musculus)
PF06367
(Drf_FH3)
PF06371
(Drf_GBD)
3 MET A 150
LEU A 153
SER A 154
None
0.62A 1ee2A-2bnxA:
undetectable
1ee2A-2bnxA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2


(Rattus
norvegicus)
PF03114
(BAR)
3 MET A 121
LEU A 124
SER A 125
None
0.69A 1ee2A-2c08A:
undetectable
1ee2A-2c08A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE


(Thermus
thermophilus)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
3 MET A 249
LEU A 252
SER A 253
None
0.68A 1ee2A-2e9fA:
undetectable
1ee2A-2e9fA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd5 CHARGED
MULTIVESICULAR BODY
PROTEIN 3


(Homo sapiens)
PF03357
(Snf7)
3 MET A 127
LEU A 130
SER A 131
None
0.69A 1ee2A-2gd5A:
undetectable
1ee2A-2gd5A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvi CONSERVED
HYPOTHETICAL PROTEIN


(Thermoplasma
acidophilum)
PF02663
(FmdE)
3 MET A 108
LEU A 111
SER A 112
None
0.30A 1ee2A-2gviA:
undetectable
1ee2A-2gviA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj3 SULFHYDRYL OXIDASE
ERV1P


(Arabidopsis
thaliana)
PF04777
(Evr1_Alr)
3 MET A  45
LEU A  48
SER A  49
None
None
SO4  A 503 ( 3.9A)
0.62A 1ee2A-2hj3A:
undetectable
1ee2A-2hj3A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iai PUTATIVE
TRANSCRIPTIONAL
REGULATOR SCO3833


(Streptomyces
coelicolor)
PF00440
(TetR_N)
3 MET A  32
LEU A  35
SER A  36
None
0.68A 1ee2A-2iaiA:
undetectable
1ee2A-2iaiA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idl HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae)
PF04327
(Peptidase_Prp)
3 MET A  95
LEU A  98
SER A  99
None
0.50A 1ee2A-2idlA:
undetectable
1ee2A-2idlA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijr HYPOTHETICAL PROTEIN
API92


(Yersinia
pseudotuberculosis)
PF06924
(DUF1281)
3 MET A 238
LEU A 241
SER A 242
None
0.45A 1ee2A-2ijrA:
undetectable
1ee2A-2ijrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2


(Saccharomyces
cerevisiae)
PF03095
(PTPA)
3 MET A  56
LEU A  59
SER A  60
None
0.63A 1ee2A-2ixnA:
undetectable
1ee2A-2ixnA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4d CRYPTOCHROME DASH

(Arabidopsis
thaliana)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 MET A 380
LEU A 383
SER A 384
None
0.58A 1ee2A-2j4dA:
2.4
1ee2A-2j4dA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE


(Cryptosporidium
parvum)
PF00348
(polyprenyl_synt)
3 MET A 148
LEU A 151
SER A 152
None
0.44A 1ee2A-2o1oA:
undetectable
1ee2A-2o1oA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 MET A 952
LEU A 955
SER A 956
None
MR9  A 301 (-4.4A)
None
0.63A 1ee2A-2p4iA:
undetectable
1ee2A-2p4iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pon BECLIN-1

(Homo sapiens)
PF15285
(BH3)
3 MET A  24
LEU A  27
SER A  28
None
0.33A 1ee2A-2ponA:
undetectable
1ee2A-2ponA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 MET A 734
LEU A 737
SER A 738
None
0.52A 1ee2A-2qobA:
undetectable
1ee2A-2qobA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus)
PF00221
(Lyase_aromatic)
3 MET A 447
LEU A 150
SER A 149
None
None
MDO  A 152 ( 4.0A)
0.66A 1ee2A-2qveA:
undetectable
1ee2A-2qveA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
3 MET A 788
LEU A 791
SER A 792
None
0.56A 1ee2A-2r2pA:
undetectable
1ee2A-2r2pA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT


(Vaccinia virus)
PF03291
(Pox_MCEL)
3 MET A 694
LEU A 697
SER A 698
None
0.56A 1ee2A-2vdwA:
6.0
1ee2A-2vdwA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
3 MET A 734
LEU A 737
SER A 738
None
0.50A 1ee2A-2xyuA:
undetectable
1ee2A-2xyuA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER


(Pseudomonas
putida)
PF16591
(HBM)
3 MET A 148
LEU A 151
SER A 152
None
0.36A 1ee2A-2yfbA:
undetectable
1ee2A-2yfbA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA


(Chlorobaculum
tepidum)
PF01134
(GIDA)
PF13932
(GIDA_assoc)
3 MET A 476
LEU A 505
SER A 506
None
0.67A 1ee2A-3cp8A:
4.0
1ee2A-3cp8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frv CHARGED
MULTIVESICULAR BODY
PROTEIN 3


(Homo sapiens)
PF03357
(Snf7)
3 MET A 127
LEU A 130
SER A 131
None
0.61A 1ee2A-3frvA:
undetectable
1ee2A-3frvA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1p PROTEIN PHNP

(Escherichia
coli)
PF12706
(Lactamase_B_2)
3 MET A 186
LEU A 162
SER A 163
None
0.60A 1ee2A-3g1pA:
undetectable
1ee2A-3g1pA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
3 MET A 748
LEU A 751
SER A 752
None
0.42A 1ee2A-3kulA:
undetectable
1ee2A-3kulA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN


(Rhodopseudomonas
palustris)
PF02743
(dCache_1)
3 MET A  56
LEU A  59
SER A  60
None
0.53A 1ee2A-3lifA:
undetectable
1ee2A-3lifA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpz GET4 (YOR164C
HOMOLOG)


(Chaetomium
thermophilum)
PF04190
(DUF410)
3 MET A 243
LEU A 246
SER A 247
None
0.38A 1ee2A-3lpzA:
undetectable
1ee2A-3lpzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhv BH2092 PROTEIN

(Bacillus
halodurans)
PF00581
(Rhodanese)
3 MET A  26
LEU A  29
SER A  30
None
0.59A 1ee2A-3nhvA:
undetectable
1ee2A-3nhvA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P


(Drosophila
melanogaster)
PF11701
(UNC45-central)
3 MET A 889
LEU A 892
SER A 893
None
0.50A 1ee2A-3nowA:
undetectable
1ee2A-3nowA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3w BH2092 PROTEIN

(Bacillus
halodurans)
PF00581
(Rhodanese)
3 MET A  26
LEU A  29
SER A  30
None
0.63A 1ee2A-3o3wA:
undetectable
1ee2A-3o3wA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1


(Homo sapiens)
PF00621
(RhoGEF)
3 MET A 634
LEU A 635
SER A 636
None
0.62A 1ee2A-3odwA:
undetectable
1ee2A-3odwA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oon OUTER MEMBRANE
PROTEIN (TPN50)


(Borreliella
burgdorferi)
PF00691
(OmpA)
3 MET A 331
LEU A 334
SER A 335
SO4  A 401 ( 4.0A)
None
None
0.45A 1ee2A-3oonA:
undetectable
1ee2A-3oonA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1


(Homo sapiens)
PF09735
(Nckap1)
3 MET B 144
LEU B 147
SER B 148
None
0.52A 1ee2A-3p8cB:
undetectable
1ee2A-3p8cB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfs BROMODOMAIN AND PHD
FINGER-CONTAINING
PROTEIN 3


(Homo sapiens)
PF00855
(PWWP)
3 MET A1187
LEU A1190
SER A1191
None
0.63A 1ee2A-3pfsA:
undetectable
1ee2A-3pfsA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H


(Human
gammaherpesvirus
4)
no annotation 3 MET A 361
LEU A 364
SER A 398
None
0.57A 1ee2A-3phfA:
undetectable
1ee2A-3phfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE


(Campylobacter
jejuni)
PF00215
(OMPdecase)
3 MET A  98
LEU A 101
SER A 102
None
0.63A 1ee2A-3ru6A:
undetectable
1ee2A-3ru6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis)
PF00128
(Alpha-amylase)
3 MET A 155
LEU A 158
SER A 159
None
0.69A 1ee2A-3ucqA:
0.7
1ee2A-3ucqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viq SWI5-DEPENDENT
RECOMBINATION DNA
REPAIR PROTEIN 1


(Schizosaccharomyces
pombe)
PF10376
(Mei5)
3 MET A 180
LEU A 183
SER A 184
None
0.61A 1ee2A-3viqA:
undetectable
1ee2A-3viqA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsb FARNESYLTRANSFERASE,
PUTATIVE


(Trypanosoma
cruzi)
PF00494
(SQS_PSY)
3 MET A 291
LEU A 294
SER A 295
None
0.66A 1ee2A-3wsbA:
undetectable
1ee2A-3wsbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4


(Mus musculus)
PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
3 MET A 298
LEU A 301
SER A 302
None
0.67A 1ee2A-4f7zA:
undetectable
1ee2A-4f7zA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3


(Mus musculus)
PF07714
(Pkinase_Tyr)
3 MET A 633
LEU A 636
SER A 637
None
0.62A 1ee2A-4feqA:
undetectable
1ee2A-4feqA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3


(Legionella
pneumophila)
no annotation 3 MET A 630
LEU A 633
SER A 634
None
0.35A 1ee2A-4fyeA:
2.9
1ee2A-4fyeA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1


(Homo sapiens)
PF03493
(BK_channel_a)
3 MET A 431
LEU A 434
SER A 435
None
0.64A 1ee2A-4hpfA:
4.9
1ee2A-4hpfA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inw PHEROMONE-BINDING
PROTEIN 1


(Amyelois
transitella)
PF01395
(PBP_GOBP)
3 MET A   5
LEU A   8
SER A   9
1EY  A 201 (-4.6A)
1EY  A 201 (-3.9A)
None
0.61A 1ee2A-4inwA:
undetectable
1ee2A-4inwA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inw PHEROMONE-BINDING
PROTEIN 1


(Amyelois
transitella)
PF01395
(PBP_GOBP)
3 MET A 109
LEU A 112
SER A 113
None
0.38A 1ee2A-4inwA:
undetectable
1ee2A-4inwA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is4 GLUTAMINE SYNTHETASE

(Medicago
truncatula)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
3 MET A   1
LEU A   4
SER A   5
None
0.66A 1ee2A-4is4A:
undetectable
1ee2A-4is4A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgp SPORULATION KINASE D

(Bacillus
subtilis)
PF02743
(dCache_1)
3 MET A  73
LEU A  76
SER A  77
None
0.48A 1ee2A-4jgpA:
undetectable
1ee2A-4jgpA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6e MRNA-DECAPPING
ENZYME SUBUNIT 2


(Saccharomyces
cerevisiae)
PF00293
(NUDIX)
3 MET A 228
LEU A 231
SER A 232
None
0.66A 1ee2A-4k6eA:
undetectable
1ee2A-4k6eA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p79 CLAUDIN-15

(Mus musculus)
PF00822
(PMP22_Claudin)
3 MET A  68
LEU A  71
SER A  72
None
0.48A 1ee2A-4p79A:
undetectable
1ee2A-4p79A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288


(Thermotoga
maritima)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
3 MET B 101
LEU B 104
SER B 105
None
0.46A 1ee2A-4q4aB:
undetectable
1ee2A-4q4aB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis)
PF00285
(Citrate_synt)
3 MET A 134
LEU A 137
SER A 138
None
0.61A 1ee2A-4tvmA:
undetectable
1ee2A-4tvmA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wph UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7


(Homo sapiens)
PF12436
(USP7_ICP0_bdg)
3 MET A 648
LEU A 651
SER A 652
None
0.68A 1ee2A-4wphA:
undetectable
1ee2A-4wphA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H


(Human
alphaherpesvirus
3)
PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
3 MET A 590
LEU A 593
SER A 594
None
0.56A 1ee2A-4xhjA:
undetectable
1ee2A-4xhjA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER


(Streptococcus
thermophilus)
PF00854
(PTR2)
3 MET A  66
LEU A  69
SER A  70
None
0.63A 1ee2A-4xniA:
undetectable
1ee2A-4xniA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER


(Streptococcus
thermophilus)
PF00854
(PTR2)
3 MET A 426
LEU A 429
SER A 430
None
0.61A 1ee2A-4xniA:
undetectable
1ee2A-4xniA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE


(Vesicular
stomatitis
virus)
PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap)
3 MET A1198
LEU A1201
SER A1202
None
0.67A 1ee2A-5a22A:
undetectable
1ee2A-5a22A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4r METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
D HOMOLOG,
MITOCHONDRIAL


(Mus musculus)
PF10229
(MMADHC)
3 MET A 290
LEU A 293
SER A 294
None
0.49A 1ee2A-5a4rA:
undetectable
1ee2A-5a4rA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus)
PF04196
(Bunya_RdRp)
PF15518
(L_protein_N)
3 MET A1557
LEU A1560
SER A1561
None
0.68A 1ee2A-5amqA:
undetectable
1ee2A-5amqA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE


(Thermotoga
neapolitana)
PF00933
(Glyco_hydro_3)
3 MET A  49
LEU A  52
SER A  53
None
0.60A 1ee2A-5bzaA:
undetectable
1ee2A-5bzaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7


(Homo sapiens)
PF12436
(USP7_ICP0_bdg)
3 MET A 648
LEU A 651
SER A 652
MET  A 648 ( 0.0A)
LEU  A 651 ( 0.5A)
SER  A 652 ( 0.0A)
0.65A 1ee2A-5c6dA:
undetectable
1ee2A-5c6dA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE


(Pseudomonas
putida)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
3 MET A  79
LEU A  82
SER A  83
None
0.59A 1ee2A-5dgtA:
undetectable
1ee2A-5dgtA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE


(Streptomyces
coelicolor)
no annotation 3 MET A 163
LEU A 166
SER A 167
None
0.58A 1ee2A-5dz2A:
undetectable
1ee2A-5dz2A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1


(Homo sapiens)
PF00083
(Sugar_tr)
3 MET A 364
LEU A 367
SER A 368
None
0.53A 1ee2A-5eqiA:
undetectable
1ee2A-5eqiA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA


(Saccharomyces
cerevisiae)
PF00118
(Cpn60_TCP1)
3 MET g  78
LEU g  81
SER g  82
None
0.65A 1ee2A-5gw4g:
undetectable
1ee2A-5gw4g:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A


(Homo sapiens;
Dictyostelium
discoideum)
PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N)
3 MET A 682
LEU A 685
SER A 686
None
0.67A 1ee2A-5i4eA:
undetectable
1ee2A-5i4eA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4a TRNA NUCLEASE CDIA

(Burkholderia
pseudomallei)
no annotation 3 MET A 269
LEU A 272
SER A 273
None
0.66A 1ee2A-5j4aA:
undetectable
1ee2A-5j4aA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7


(Homo sapiens)
PF00443
(UCH)
PF12436
(USP7_ICP0_bdg)
3 MET A 648
LEU A 651
SER A 652
None
0.61A 1ee2A-5j7tA:
undetectable
1ee2A-5j7tA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsz CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN


(Lactobacillus
delbrueckii)
PF12822
(ECF_trnsprt)
3 MET C 139
LEU C 142
SER C 143
None
0.49A 1ee2A-5jszC:
undetectable
1ee2A-5jszC:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 MET A 746
LEU A 749
SER A 750
None
0.54A 1ee2A-5l6oA:
undetectable
1ee2A-5l6oA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd MON1

(Chaetomium
thermophilum)
PF03164
(Mon1)
3 MET A 308
LEU A 311
SER A 312
None
0.36A 1ee2A-5lddA:
undetectable
1ee2A-5lddA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN


(Leishmania
mexicana)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
3 MET A  61
LEU A  66
SER A  67
None
0.63A 1ee2A-5lnqA:
undetectable
1ee2A-5lnqA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2


(Eremothecium
gossypii)
PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C)
3 MET A 919
LEU A 922
SER A 923
None
0.64A 1ee2A-5me3A:
undetectable
1ee2A-5me3A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjv CAPSID SUBUNIT VP3

(Parechovirus A)
no annotation 3 MET B 236
LEU B 139
SER B 138
None
0.62A 1ee2A-5mjvB:
undetectable
1ee2A-5mjvB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE


(Ruminiclostridium
thermocellum)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
3 MET A 694
LEU A 697
SER A 698
None
0.60A 1ee2A-5nz7A:
undetectable
1ee2A-5nz7A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o30 PUTATIVE
OXIDOREDUCTASE


(Ilumatobacter
coccineus)
PF13561
(adh_short_C2)
3 MET A 231
LEU A 234
SER A 235
None
0.38A 1ee2A-5o30A:
undetectable
1ee2A-5o30A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5


(Homo sapiens)
no annotation 3 MET A 269
LEU A 272
SER A 273
None
0.62A 1ee2A-5o8fA:
undetectable
1ee2A-5o8fA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE


(Papaver
somniferum)
no annotation 3 MET A 182
LEU A 185
SER A 186
None
EDO  A 412 ( 4.0A)
None
0.53A 1ee2A-5o9wA:
undetectable
1ee2A-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B


(Homo sapiens)
PF08210
(APOBEC_N)
3 MET A  69
LEU A  72
SER A  73
None
0.61A 1ee2A-5tkmA:
undetectable
1ee2A-5tkmA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1d ANTIGEN PEPTIDE
TRANSPORTER 2


(Homo sapiens)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
3 MET B 389
LEU B 392
SER B 393
None
0.66A 1ee2A-5u1dB:
undetectable
1ee2A-5u1dB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO


(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 MET A 660
LEU A 663
SER A 664
None
0.50A 1ee2A-5u6bA:
undetectable
1ee2A-5u6bA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE


(Hydrogenophilus
thermoluteolus)
PF00374
(NiFeSe_Hases)
3 MET D 202
LEU D 205
SER D 206
None
0.45A 1ee2A-5xfaD:
undetectable
1ee2A-5xfaD:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861


(Pseudomonas
aeruginosa)
no annotation 3 MET A 367
LEU A 370
SER A 371
None
0.69A 1ee2A-5xgeA:
undetectable
1ee2A-5xgeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN


(Electrophorus
electricus)
PF00520
(Ion_trans)
PF06512
(Na_trans_assoc)
3 MET A1009
LEU A1012
SER A1013
None
0.68A 1ee2A-5xsyA:
undetectable
1ee2A-5xsyA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9p -

(-)
no annotation 3 MET A 208
LEU A 211
SER A 212
None
0.35A 1ee2A-5y9pA:
undetectable
1ee2A-5y9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2


(Homo sapiens)
no annotation 3 MET E 276
LEU E 279
SER E 280
None
0.36A 1ee2A-6d6uE:
undetectable
1ee2A-6d6uE:
22.62