SIMILAR PATTERNS OF AMINO ACIDS FOR 1EE2_B_CHDB1250_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dcn | DELTA 2 CRYSTALLIN (Anasplatyrhynchos) |
PF00206(Lyase_1)PF14698(ASL_C2) | 3 | MET A 252LEU A 255SER A 256 | None | 0.54A | 1ee2A-1dcnA:0.0 | 1ee2A-1dcnA:22.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ee2 | ALCOHOLDEHYDROGENASE (Equus caballus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | MET A 305LEU A 308SER A 309 | None | 0.00A | 1ee2A-1ee2A:71.0 | 1ee2A-1ee2A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ezj | NUCLEOCAPSIDPHOSPHOPROTEIN (Murinerespirovirus) |
PF01806(Paramyxo_P) | 3 | MET A 104LEU A 107SER A 108 | None | 0.61A | 1ee2A-1ezjA:undetectable | 1ee2A-1ezjA:14.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hbr | PROTEIN (HEMOGLOBIND) (Gallus gallus) |
PF00042(Globin) | 3 | MET A 80LEU A 83SER A 84 | NoneHEM A 142 (-4.6A)None | 0.54A | 1ee2A-1hbrA:undetectable | 1ee2A-1hbrA:16.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hle | HORSE LEUKOCYTEELASTASE INHIBITOR (Equus caballus) |
PF00079(Serpin) | 3 | MET A 23LEU A 26SER A 27 | ACE A 22 ( 4.2A)NoneNone | 0.54A | 1ee2A-1hleA:undetectable | 1ee2A-1hleA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i0a | DELTA CRYSTALLIN I (Meleagrisgallopavo) |
PF00206(Lyase_1)PF14698(ASL_C2) | 3 | MET A 250LEU A 253SER A 254 | None | 0.58A | 1ee2A-1i0aA:0.0 | 1ee2A-1i0aA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1izo | CYTOCHROME P450152A1 (Bacillussubtilis) |
PF00067(p450) | 3 | MET A 97LEU A 100SER A 101 | None | 0.56A | 1ee2A-1izoA:undetectable | 1ee2A-1izoA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1luf | MUSCLE-SPECIFICTYROSINE KINASERECEPTOR MUSK (Rattusnorvegicus) |
PF07714(Pkinase_Tyr) | 3 | MET A 712LEU A 715SER A 716 | None | 0.68A | 1ee2A-1lufA:0.0 | 1ee2A-1lufA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n97 | CYP175A1 (Thermusthermophilus) |
PF00067(p450) | 3 | MET A 132LEU A 135SER A 136 | None | 0.57A | 1ee2A-1n97A:0.0 | 1ee2A-1n97A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1odt | CEPHALOSPORIN CDEACETYLASE (Bacillussubtilis) |
PF05448(AXE1) | 3 | MET C 242LEU C 245SER C 246 | None | 0.60A | 1ee2A-1odtC:2.5 | 1ee2A-1odtC:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qb4 | PHOSPHOENOLPYRUVATECARBOXYLASE (Escherichiacoli) |
PF00311(PEPcase) | 3 | MET A 657LEU A 660SER A 661 | None | 0.67A | 1ee2A-1qb4A:0.7 | 1ee2A-1qb4A:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tf1 | NEGATIVE REGULATOROF ALLANTOIN ANDGLYOXYLATEUTILIZATION OPERONS (Escherichiacoli) |
PF01614(IclR) | 3 | MET A 11LEU A 14SER A 15 | None | 0.61A | 1ee2A-1tf1A:undetectable | 1ee2A-1tf1A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tj7 | ARGININOSUCCINATELYASE (Escherichiacoli) |
PF00206(Lyase_1)PF14698(ASL_C2) | 3 | MET A 246LEU A 249SER A 250 | None | 0.56A | 1ee2A-1tj7A:undetectable | 1ee2A-1tj7A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xq8 | ALPHA-SYNUCLEIN (Homo sapiens) |
PF01387(Synuclein) | 3 | MET A 5LEU A 8SER A 9 | None | 0.68A | 1ee2A-1xq8A:undetectable | 1ee2A-1xq8A:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yb2 | HYPOTHETICAL PROTEINTA0852 (Thermoplasmaacidophilum) |
PF08704(GCD14) | 3 | MET A 132LEU A 135SER A 136 | None | 0.36A | 1ee2A-1yb2A:8.3 | 1ee2A-1yb2A:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b2i | AMMONIUM TRANSPORTER (Archaeoglobusfulgidus) |
PF00909(Ammonium_transp) | 3 | MET A 39LEU A 42SER A 43 | None | 0.68A | 1ee2A-2b2iA:undetectable | 1ee2A-2b2iA:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bnx | DIAPHANOUS PROTEINHOMOLOG 1 (Mus musculus) |
PF06367(Drf_FH3)PF06371(Drf_GBD) | 3 | MET A 150LEU A 153SER A 154 | None | 0.62A | 1ee2A-2bnxA:undetectable | 1ee2A-2bnxA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c08 | SH3-CONTAININGGRB2-LIKE PROTEIN 2 (Rattusnorvegicus) |
PF03114(BAR) | 3 | MET A 121LEU A 124SER A 125 | None | 0.69A | 1ee2A-2c08A:undetectable | 1ee2A-2c08A:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e9f | ARGININOSUCCINATELYASE (Thermusthermophilus) |
PF00206(Lyase_1)PF14698(ASL_C2) | 3 | MET A 249LEU A 252SER A 253 | None | 0.68A | 1ee2A-2e9fA:undetectable | 1ee2A-2e9fA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gd5 | CHARGEDMULTIVESICULAR BODYPROTEIN 3 (Homo sapiens) |
PF03357(Snf7) | 3 | MET A 127LEU A 130SER A 131 | None | 0.69A | 1ee2A-2gd5A:undetectable | 1ee2A-2gd5A:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gvi | CONSERVEDHYPOTHETICAL PROTEIN (Thermoplasmaacidophilum) |
PF02663(FmdE) | 3 | MET A 108LEU A 111SER A 112 | None | 0.30A | 1ee2A-2gviA:undetectable | 1ee2A-2gviA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hj3 | SULFHYDRYL OXIDASEERV1P (Arabidopsisthaliana) |
PF04777(Evr1_Alr) | 3 | MET A 45LEU A 48SER A 49 | NoneNoneSO4 A 503 ( 3.9A) | 0.62A | 1ee2A-2hj3A:undetectable | 1ee2A-2hj3A:14.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iai | PUTATIVETRANSCRIPTIONALREGULATOR SCO3833 (Streptomycescoelicolor) |
PF00440(TetR_N) | 3 | MET A 32LEU A 35SER A 36 | None | 0.68A | 1ee2A-2iaiA:undetectable | 1ee2A-2iaiA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2idl | HYPOTHETICAL PROTEIN (Streptococcuspneumoniae) |
PF04327(Peptidase_Prp) | 3 | MET A 95LEU A 98SER A 99 | None | 0.50A | 1ee2A-2idlA:undetectable | 1ee2A-2idlA:16.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijr | HYPOTHETICAL PROTEINAPI92 (Yersiniapseudotuberculosis) |
PF06924(DUF1281) | 3 | MET A 238LEU A 241SER A 242 | None | 0.45A | 1ee2A-2ijrA:undetectable | 1ee2A-2ijrA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ixn | SERINE/THREONINE-PROTEIN PHOSPHATASE 2AACTIVATOR 2 (Saccharomycescerevisiae) |
PF03095(PTPA) | 3 | MET A 56LEU A 59SER A 60 | None | 0.63A | 1ee2A-2ixnA:undetectable | 1ee2A-2ixnA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4d | CRYPTOCHROME DASH (Arabidopsisthaliana) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | MET A 380LEU A 383SER A 384 | None | 0.58A | 1ee2A-2j4dA:2.4 | 1ee2A-2j4dA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1o | PUTATIVE FARNESYLPYROPHOSPHATESYNTHASE (Cryptosporidiumparvum) |
PF00348(polyprenyl_synt) | 3 | MET A 148LEU A 151SER A 152 | None | 0.44A | 1ee2A-2o1oA:undetectable | 1ee2A-2o1oA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4i | ANGIOPOIETIN-1RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | MET A 952LEU A 955SER A 956 | NoneMR9 A 301 (-4.4A)None | 0.63A | 1ee2A-2p4iA:undetectable | 1ee2A-2p4iA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pon | BECLIN-1 (Homo sapiens) |
PF15285(BH3) | 3 | MET A 24LEU A 27SER A 28 | None | 0.33A | 1ee2A-2ponA:undetectable | 1ee2A-2ponA:6.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qob | EPHRIN RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | MET A 734LEU A 737SER A 738 | None | 0.52A | 1ee2A-2qobA:undetectable | 1ee2A-2qobA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qve | TYROSINE AMINOMUTASE (Streptomycesglobisporus) |
PF00221(Lyase_aromatic) | 3 | MET A 447LEU A 150SER A 149 | NoneNoneMDO A 152 ( 4.0A) | 0.66A | 1ee2A-2qveA:undetectable | 1ee2A-2qveA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r2p | EPHRIN TYPE-ARECEPTOR 5 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 3 | MET A 788LEU A 791SER A 792 | None | 0.56A | 1ee2A-2r2pA:undetectable | 1ee2A-2r2pA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdw | VACCINIA VIRUSCAPPING ENZYME D1SUBUNIT (Vaccinia virus) |
PF03291(Pox_MCEL) | 3 | MET A 694LEU A 697SER A 698 | None | 0.56A | 1ee2A-2vdwA:6.0 | 1ee2A-2vdwA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xyu | EPHRIN TYPE-ARECEPTOR 4, (Mus musculus) |
PF07714(Pkinase_Tyr) | 3 | MET A 734LEU A 737SER A 738 | None | 0.50A | 1ee2A-2xyuA:undetectable | 1ee2A-2xyuA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yfb | METHYL-ACCEPTINGCHEMOTAXISTRANSDUCER (Pseudomonasputida) |
PF16591(HBM) | 3 | MET A 148LEU A 151SER A 152 | None | 0.36A | 1ee2A-2yfbA:undetectable | 1ee2A-2yfbA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cp8 | TRNA URIDINE5-CARBOXYMETHYLAMINOMETHYL MODIFICATIONENZYME GIDA (Chlorobaculumtepidum) |
PF01134(GIDA)PF13932(GIDA_assoc) | 3 | MET A 476LEU A 505SER A 506 | None | 0.67A | 1ee2A-3cp8A:4.0 | 1ee2A-3cp8A:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3frv | CHARGEDMULTIVESICULAR BODYPROTEIN 3 (Homo sapiens) |
PF03357(Snf7) | 3 | MET A 127LEU A 130SER A 131 | None | 0.61A | 1ee2A-3frvA:undetectable | 1ee2A-3frvA:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1p | PROTEIN PHNP (Escherichiacoli) |
PF12706(Lactamase_B_2) | 3 | MET A 186LEU A 162SER A 163 | None | 0.60A | 1ee2A-3g1pA:undetectable | 1ee2A-3g1pA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kul | EPHRIN TYPE-ARECEPTOR 8 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 3 | MET A 748LEU A 751SER A 752 | None | 0.42A | 1ee2A-3kulA:undetectable | 1ee2A-3kulA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lif | PUTATIVE DIGUANYLATECYCLASE (GGDEF) WITHPAS/PAC DOMAIN (Rhodopseudomonaspalustris) |
PF02743(dCache_1) | 3 | MET A 56LEU A 59SER A 60 | None | 0.53A | 1ee2A-3lifA:undetectable | 1ee2A-3lifA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpz | GET4 (YOR164CHOMOLOG) (Chaetomiumthermophilum) |
PF04190(DUF410) | 3 | MET A 243LEU A 246SER A 247 | None | 0.38A | 1ee2A-3lpzA:undetectable | 1ee2A-3lpzA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nhv | BH2092 PROTEIN (Bacillushalodurans) |
PF00581(Rhodanese) | 3 | MET A 26LEU A 29SER A 30 | None | 0.59A | 1ee2A-3nhvA:undetectable | 1ee2A-3nhvA:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3now | UNC-45 PROTEIN,SD10334P (Drosophilamelanogaster) |
PF11701(UNC45-central) | 3 | MET A 889LEU A 892SER A 893 | None | 0.50A | 1ee2A-3nowA:undetectable | 1ee2A-3nowA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o3w | BH2092 PROTEIN (Bacillushalodurans) |
PF00581(Rhodanese) | 3 | MET A 26LEU A 29SER A 30 | None | 0.63A | 1ee2A-3o3wA:undetectable | 1ee2A-3o3wA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3odw | RHO GUANINENUCLEOTIDE EXCHANGEFACTOR 1 (Homo sapiens) |
PF00621(RhoGEF) | 3 | MET A 634LEU A 635SER A 636 | None | 0.62A | 1ee2A-3odwA:undetectable | 1ee2A-3odwA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oon | OUTER MEMBRANEPROTEIN (TPN50) (Borreliellaburgdorferi) |
PF00691(OmpA) | 3 | MET A 331LEU A 334SER A 335 | SO4 A 401 ( 4.0A)NoneNone | 0.45A | 1ee2A-3oonA:undetectable | 1ee2A-3oonA:16.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8c | NCK-ASSOCIATEDPROTEIN 1 (Homo sapiens) |
PF09735(Nckap1) | 3 | MET B 144LEU B 147SER B 148 | None | 0.52A | 1ee2A-3p8cB:undetectable | 1ee2A-3p8cB:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pfs | BROMODOMAIN AND PHDFINGER-CONTAININGPROTEIN 3 (Homo sapiens) |
PF00855(PWWP) | 3 | MET A1187LEU A1190SER A1191 | None | 0.63A | 1ee2A-3pfsA:undetectable | 1ee2A-3pfsA:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3phf | ENVELOPEGLYCOPROTEIN H (Humangammaherpesvirus4) |
no annotation | 3 | MET A 361LEU A 364SER A 398 | None | 0.57A | 1ee2A-3phfA:undetectable | 1ee2A-3phfA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ru6 | OROTIDINE5'-PHOSPHATEDECARBOXYLASE (Campylobacterjejuni) |
PF00215(OMPdecase) | 3 | MET A 98LEU A 101SER A 102 | None | 0.63A | 1ee2A-3ru6A:undetectable | 1ee2A-3ru6A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ucq | AMYLOSUCRASE (Deinococcusgeothermalis) |
PF00128(Alpha-amylase) | 3 | MET A 155LEU A 158SER A 159 | None | 0.69A | 1ee2A-3ucqA:0.7 | 1ee2A-3ucqA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3viq | SWI5-DEPENDENTRECOMBINATION DNAREPAIR PROTEIN 1 (Schizosaccharomycespombe) |
PF10376(Mei5) | 3 | MET A 180LEU A 183SER A 184 | None | 0.61A | 1ee2A-3viqA:undetectable | 1ee2A-3viqA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wsb | FARNESYLTRANSFERASE,PUTATIVE (Trypanosomacruzi) |
PF00494(SQS_PSY) | 3 | MET A 291LEU A 294SER A 295 | None | 0.66A | 1ee2A-3wsbA:undetectable | 1ee2A-3wsbA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f7z | RAP GUANINENUCLEOTIDE EXCHANGEFACTOR 4 (Mus musculus) |
PF00027(cNMP_binding)PF00610(DEP)PF00617(RasGEF)PF00618(RasGEF_N) | 3 | MET A 298LEU A 301SER A 302 | None | 0.67A | 1ee2A-4f7zA:undetectable | 1ee2A-4f7zA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4feq | TYROSINE-PROTEINKINASE RECEPTORTYRO3 (Mus musculus) |
PF07714(Pkinase_Tyr) | 3 | MET A 633LEU A 636SER A 637 | None | 0.62A | 1ee2A-4feqA:undetectable | 1ee2A-4feqA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fye | SIDF, INHIBITOR OFGROWTH FAMILY,MEMBER 3 (Legionellapneumophila) |
no annotation | 3 | MET A 630LEU A 633SER A 634 | None | 0.35A | 1ee2A-4fyeA:2.9 | 1ee2A-4fyeA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hpf | POTASSIUM CHANNELSUBFAMILY U MEMBER 1 (Homo sapiens) |
PF03493(BK_channel_a) | 3 | MET A 431LEU A 434SER A 435 | None | 0.64A | 1ee2A-4hpfA:4.9 | 1ee2A-4hpfA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inw | PHEROMONE-BINDINGPROTEIN 1 (Amyeloistransitella) |
PF01395(PBP_GOBP) | 3 | MET A 5LEU A 8SER A 9 | 1EY A 201 (-4.6A)1EY A 201 (-3.9A)None | 0.61A | 1ee2A-4inwA:undetectable | 1ee2A-4inwA:15.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inw | PHEROMONE-BINDINGPROTEIN 1 (Amyeloistransitella) |
PF01395(PBP_GOBP) | 3 | MET A 109LEU A 112SER A 113 | None | 0.38A | 1ee2A-4inwA:undetectable | 1ee2A-4inwA:15.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4is4 | GLUTAMINE SYNTHETASE (Medicagotruncatula) |
PF00120(Gln-synt_C)PF03951(Gln-synt_N) | 3 | MET A 1LEU A 4SER A 5 | None | 0.66A | 1ee2A-4is4A:undetectable | 1ee2A-4is4A:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jgp | SPORULATION KINASE D (Bacillussubtilis) |
PF02743(dCache_1) | 3 | MET A 73LEU A 76SER A 77 | None | 0.48A | 1ee2A-4jgpA:undetectable | 1ee2A-4jgpA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6e | MRNA-DECAPPINGENZYME SUBUNIT 2 (Saccharomycescerevisiae) |
PF00293(NUDIX) | 3 | MET A 228LEU A 231SER A 232 | None | 0.66A | 1ee2A-4k6eA:undetectable | 1ee2A-4k6eA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p79 | CLAUDIN-15 (Mus musculus) |
PF00822(PMP22_Claudin) | 3 | MET A 68LEU A 71SER A 72 | None | 0.48A | 1ee2A-4p79A:undetectable | 1ee2A-4p79A:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q4a | UNCHARACTERIZED ABCTRANSPORTERATP-BINDING PROTEINTM_0288 (Thermotogamaritima) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 3 | MET B 101LEU B 104SER B 105 | None | 0.46A | 1ee2A-4q4aB:undetectable | 1ee2A-4q4aB:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tvm | CITRATE SYNTHASE (Mycobacteriumtuberculosis) |
PF00285(Citrate_synt) | 3 | MET A 134LEU A 137SER A 138 | None | 0.61A | 1ee2A-4tvmA:undetectable | 1ee2A-4tvmA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wph | UBIQUITINCARBOXYL-TERMINALHYDROLASE 7 (Homo sapiens) |
PF12436(USP7_ICP0_bdg) | 3 | MET A 648LEU A 651SER A 652 | None | 0.68A | 1ee2A-4wphA:undetectable | 1ee2A-4wphA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhj | ENVELOPEGLYCOPROTEIN H (Humanalphaherpesvirus3) |
PF02489(Herpes_glycop_H)PF17488(Herpes_glycoH_C) | 3 | MET A 590LEU A 593SER A 594 | None | 0.56A | 1ee2A-4xhjA:undetectable | 1ee2A-4xhjA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xni | DI-OR TRIPEPTIDE:H+SYMPORTER (Streptococcusthermophilus) |
PF00854(PTR2) | 3 | MET A 66LEU A 69SER A 70 | None | 0.63A | 1ee2A-4xniA:undetectable | 1ee2A-4xniA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xni | DI-OR TRIPEPTIDE:H+SYMPORTER (Streptococcusthermophilus) |
PF00854(PTR2) | 3 | MET A 426LEU A 429SER A 430 | None | 0.61A | 1ee2A-4xniA:undetectable | 1ee2A-4xniA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a22 | VESICULAR STOMATITISVIRUS L POLYMERASE (Vesicularstomatitisvirus) |
PF00946(Mononeg_RNA_pol)PF14314(Methyltrans_Mon)PF14318(Mononeg_mRNAcap) | 3 | MET A1198LEU A1201SER A1202 | None | 0.67A | 1ee2A-5a22A:undetectable | 1ee2A-5a22A:10.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a4r | METHYLMALONICACIDURIA ANDHOMOCYSTINURIA TYPED HOMOLOG,MITOCHONDRIAL (Mus musculus) |
PF10229(MMADHC) | 3 | MET A 290LEU A 293SER A 294 | None | 0.49A | 1ee2A-5a4rA:undetectable | 1ee2A-5a4rA:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5amq | RNA POLYMERASE L (Californiaencephalitisorthobunyavirus) |
PF04196(Bunya_RdRp)PF15518(L_protein_N) | 3 | MET A1557LEU A1560SER A1561 | None | 0.68A | 1ee2A-5amqA:undetectable | 1ee2A-5amqA:10.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bza | BETA-N-ACETYLHEXOSAMINIDASE (Thermotoganeapolitana) |
PF00933(Glyco_hydro_3) | 3 | MET A 49LEU A 52SER A 53 | None | 0.60A | 1ee2A-5bzaA:undetectable | 1ee2A-5bzaA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c6d | UBIQUITINCARBOXYL-TERMINALHYDROLASE 7 (Homo sapiens) |
PF12436(USP7_ICP0_bdg) | 3 | MET A 648LEU A 651SER A 652 | MET A 648 ( 0.0A)LEU A 651 ( 0.5A)SER A 652 ( 0.0A) | 0.65A | 1ee2A-5c6dA:undetectable | 1ee2A-5c6dA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dgt | BENZOYLFORMATEDECARBOXYLASE (Pseudomonasputida) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 3 | MET A 79LEU A 82SER A 83 | None | 0.59A | 1ee2A-5dgtA:undetectable | 1ee2A-5dgtA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dz2 | GERMACRADIENOL/GEOSMIN SYNTHASE (Streptomycescoelicolor) |
no annotation | 3 | MET A 163LEU A 166SER A 167 | None | 0.58A | 1ee2A-5dz2A:undetectable | 1ee2A-5dz2A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eqi | SOLUTE CARRIERFAMILY 2,FACILITATED GLUCOSETRANSPORTER MEMBER 1 (Homo sapiens) |
PF00083(Sugar_tr) | 3 | MET A 364LEU A 367SER A 368 | None | 0.53A | 1ee2A-5eqiA:undetectable | 1ee2A-5eqiA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw4 | T-COMPLEX PROTEIN 1SUBUNIT GAMMA (Saccharomycescerevisiae) |
PF00118(Cpn60_TCP1) | 3 | MET g 78LEU g 81SER g 82 | None | 0.65A | 1ee2A-5gw4g:undetectable | 1ee2A-5gw4g:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i4e | MYOSIN-14,ALPHA-ACTININ A (Homo sapiens;Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF00435(Spectrin)PF02736(Myosin_N) | 3 | MET A 682LEU A 685SER A 686 | None | 0.67A | 1ee2A-5i4eA:undetectable | 1ee2A-5i4eA:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j4a | TRNA NUCLEASE CDIA (Burkholderiapseudomallei) |
no annotation | 3 | MET A 269LEU A 272SER A 273 | None | 0.66A | 1ee2A-5j4aA:undetectable | 1ee2A-5j4aA:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j7t | UBIQUITINCARBOXYL-TERMINALHYDROLASE 7 (Homo sapiens) |
PF00443(UCH)PF12436(USP7_ICP0_bdg) | 3 | MET A 648LEU A 651SER A 652 | None | 0.61A | 1ee2A-5j7tA:undetectable | 1ee2A-5j7tA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jsz | CONSERVEDHYPOTHETICALMEMBRANE PROTEIN (Lactobacillusdelbrueckii) |
PF12822(ECF_trnsprt) | 3 | MET C 139LEU C 142SER C 143 | None | 0.49A | 1ee2A-5jszC:undetectable | 1ee2A-5jszC:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l6o | EPHRIN TYPE-BRECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | MET A 746LEU A 749SER A 750 | None | 0.54A | 1ee2A-5l6oA:undetectable | 1ee2A-5l6oA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldd | MON1 (Chaetomiumthermophilum) |
PF03164(Mon1) | 3 | MET A 308LEU A 311SER A 312 | None | 0.36A | 1ee2A-5lddA:undetectable | 1ee2A-5lddA:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lnq | 3-KETOACYL-COATHIOLASE-LIKEPROTEIN (Leishmaniamexicana) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 3 | MET A 61LEU A 66SER A 67 | None | 0.63A | 1ee2A-5lnqA:undetectable | 1ee2A-5lnqA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5me3 | SISTER CHROMATIDCOHESION PROTEIN 2 (Eremotheciumgossypii) |
PF12765(Cohesin_HEAT)PF12830(Nipped-B_C) | 3 | MET A 919LEU A 922SER A 923 | None | 0.64A | 1ee2A-5me3A:undetectable | 1ee2A-5me3A:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mjv | CAPSID SUBUNIT VP3 (Parechovirus A) |
no annotation | 3 | MET B 236LEU B 139SER B 138 | None | 0.62A | 1ee2A-5mjvB:undetectable | 1ee2A-5mjvB:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nz7 | CELLODEXTRINPHOSPHORYLASE (Ruminiclostridiumthermocellum) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 3 | MET A 694LEU A 697SER A 698 | None | 0.60A | 1ee2A-5nz7A:undetectable | 1ee2A-5nz7A:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o30 | PUTATIVEOXIDOREDUCTASE (Ilumatobactercoccineus) |
PF13561(adh_short_C2) | 3 | MET A 231LEU A 234SER A 235 | None | 0.38A | 1ee2A-5o30A:undetectable | 1ee2A-5o30A:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o8f | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITBETA-3,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNITALPHA-5,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-5 (Homo sapiens) |
no annotation | 3 | MET A 269LEU A 272SER A 273 | None | 0.62A | 1ee2A-5o8fA:undetectable | 1ee2A-5o8fA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o9w | THEBAINE6-O-DEMETHYLASE (Papaversomniferum) |
no annotation | 3 | MET A 182LEU A 185SER A 186 | NoneEDO A 412 ( 4.0A)None | 0.53A | 1ee2A-5o9wA:undetectable | 1ee2A-5o9wA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tkm | DNA DC->DU-EDITINGENZYME APOBEC-3B (Homo sapiens) |
PF08210(APOBEC_N) | 3 | MET A 69LEU A 72SER A 73 | None | 0.61A | 1ee2A-5tkmA:undetectable | 1ee2A-5tkmA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u1d | ANTIGEN PEPTIDETRANSPORTER 2 (Homo sapiens) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 3 | MET B 389LEU B 392SER B 393 | None | 0.66A | 1ee2A-5u1dB:undetectable | 1ee2A-5u1dB:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u6b | TYROSINE-PROTEINKINASE RECEPTOR UFO (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | MET A 660LEU A 663SER A 664 | None | 0.50A | 1ee2A-5u6bA:undetectable | 1ee2A-5u6bA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfa | NAD-REDUCINGHYDROGENASE (Hydrogenophilusthermoluteolus) |
PF00374(NiFeSe_Hases) | 3 | MET D 202LEU D 205SER D 206 | None | 0.45A | 1ee2A-5xfaD:undetectable | 1ee2A-5xfaD:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xge | UNCHARACTERIZEDPROTEIN PA0861 (Pseudomonasaeruginosa) |
no annotation | 3 | MET A 367LEU A 370SER A 371 | None | 0.69A | 1ee2A-5xgeA:undetectable | 1ee2A-5xgeA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xsy | SODIUM CHANNELPROTEIN (Electrophoruselectricus) |
PF00520(Ion_trans)PF06512(Na_trans_assoc) | 3 | MET A1009LEU A1012SER A1013 | None | 0.68A | 1ee2A-5xsyA:undetectable | 1ee2A-5xsyA:12.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y9p | - (-) |
no annotation | 3 | MET A 208LEU A 211SER A 212 | None | 0.35A | 1ee2A-5y9pA:undetectable | 1ee2A-5y9pA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6u | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITGAMMA-2,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT GAMMA-2 (Homo sapiens) |
no annotation | 3 | MET E 276LEU E 279SER E 280 | None | 0.36A | 1ee2A-6d6uE:undetectable | 1ee2A-6d6uE:22.62 |