SIMILAR PATTERNS OF AMINO ACIDS FOR 1EE2_A_CHDA1150_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ee2 ALCOHOL
DEHYDROGENASE

(Equus caballus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLU A 283
MET A 305
LEU A 308
SER A 309
 None
 0.07A 1ee2B-1ee2A:
68.6		 1ee2B-1ee2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 GLU A 504
MET A 496
LEU A 501
SER A 502
 None
 1.34A 1ee2B-1eovA:
0.0		 1ee2B-1eovA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF13476
(AAA_23)
PF13304
(AAA_21) 		4 GLU B 815
MET A   1
LEU B 818
SER B 817
 None
 1.29A 1ee2B-1ii8B:
0.7		 1ee2B-1ii8B:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF13476
(AAA_23)
no annotation 		4 GLU B 815
MET A   1
LEU B 818
SER B 817
 None
 1.39A 1ee2B-1us8B:
0.9		 1ee2B-1us8B:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		4 GLU A  67
MET A 143
LEU A   6
SER A   5
 None
 1.21A 1ee2B-2zi8A:
0.0		 1ee2B-2zi8A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 GLU A 238
MET A 292
LEU A 165
SER A 166
 None
 1.45A 1ee2B-3ef1A:
2.7		 1ee2B-3ef1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4p PROTEASOME SUBUNIT
BETA

(Methanocaldococcus
jannaschii) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 GLU a 130
MET a 127
LEU a 121
SER a 120
 None
 1.35A 1ee2B-3h4pa:
0.0		 1ee2B-3h4pa:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nre ALDOSE 1-EPIMERASE

(Escherichia
coli) 		PF01263
(Aldose_epim) 		4 GLU A 282
MET A 223
LEU A 285
SER A 284
 None
 1.44A 1ee2B-3nreA:
undetectable		 1ee2B-3nreA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 GLU A 160
MET A 151
LEU A 128
SER A 127
 None
 1.44A 1ee2B-4acqA:
undetectable		 1ee2B-4acqA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyz UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF12436
(USP7_ICP0_bdg) 		4 GLU A 655
MET A 648
LEU A 651
SER A 652
 None
 1.28A 1ee2B-4pyzA:
undetectable		 1ee2B-4pyzA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLU B 470
MET B 433
LEU B 436
SER B 437
 None
 1.31A 1ee2B-4qiwB:
undetectable		 1ee2B-4qiwB:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 GLU A 238
MET A 292
LEU A 165
SER A 166
 None
 1.43A 1ee2B-4xpzA:
undetectable		 1ee2B-4xpzA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF12436
(USP7_ICP0_bdg)
PF14533
(USP7_C2) 		4 GLU A 655
MET A 648
LEU A 651
SER A 652
 None
 1.22A 1ee2B-4z96A:
undetectable		 1ee2B-4z96A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5di0 NATTERIN-LIKE
PROTEIN

(Danio rerio) 		PF03318
(ETX_MTX2) 		4 GLU A 113
MET A 116
LEU A  77
SER A  78
 PG4  A 416 (-3.4A)
None
None
PG4  A 416 ( 4.0A)
 1.45A 1ee2B-5di0A:
undetectable		 1ee2B-5di0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 GLU A 171
MET A 163
LEU A 166
SER A 167
 None
 1.46A 1ee2B-5dz2A:
undetectable		 1ee2B-5dz2A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		4 GLU A 655
MET A 648
LEU A 651
SER A 652
 None
 1.10A 1ee2B-5j7tA:
undetectable		 1ee2B-5j7tA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 4 GLU A 269
MET A 262
LEU A 266
SER A 267
 None
 0.93A 1ee2B-5vqdA:
1.7		 1ee2B-5vqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 GLU A1082
MET A1085
LEU A1042
SER A1043
 None
 1.11A 1ee2B-5x7sA:
undetectable		 1ee2B-5x7sA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9p -

(-) 		no annotation 4 GLU A 221
MET A 208
LEU A 211
SER A 212
 None
 0.80A 1ee2B-5y9pA:
undetectable		 1ee2B-5y9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A 789
MET A 794
LEU A 795
SER A 792
 None
 1.23A 1ee2B-6c6lA:
undetectable		 1ee2B-6c6lA:
undetectable