SIMILAR PATTERNS OF AMINO ACIDS FOR 1EA1_A_TPFA470

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 PHE A 318
MET A 313
PHE A 309
LEU A 345
 None
 0.99A 1ea1A-1fc4A:
undetectable		 1ea1A-1fc4A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 MET A 189
PHE A 185
THR A 332
LEU A 328
 SAM  A1699 ( 4.2A)
None
None
None
 1.01A 1ea1A-1fpqA:
undetectable		 1ea1A-1fpqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkt HEAT-SHOCK
TRANSCRIPTION FACTOR

(Drosophila
melanogaster) 		PF00447
(HSF_DNA-bind) 		4 TYR A  92
PHE A 100
THR A  62
LEU A  56
 None
 1.28A 1ea1A-1hktA:
0.0		 1ea1A-1hktA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		4 TYR A  96
PHE A 100
MET A  92
THR A  48
 NAG  A 461 ( 4.3A)
None
None
None
 1.25A 1ea1A-1ituA:
undetectable		 1ea1A-1ituA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 TYR A 137
PHE A 138
ARG A  86
PHE A 130
 None
 1.07A 1ea1A-1kl7A:
2.2		 1ea1A-1kl7A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		4 PHE A  73
MET A  67
PHE A 171
LEU A 205
 None
 1.27A 1ea1A-1pd5A:
undetectable		 1ea1A-1pd5A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqj FUMARYLACETOACETATE
HYDROLASE

(Mus musculus) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		4 MET A 270
PHE A 295
THR A 325
LEU A 327
 None
 1.30A 1ea1A-1qqjA:
undetectable		 1ea1A-1qqjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 TYR A 182
PHE A 172
PHE A 102
THR A  99
 None
 1.11A 1ea1A-1uz4A:
0.0		 1ea1A-1uz4A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhm PROTEIN YEBR

(Escherichia
coli) 		PF13185
(GAF_2) 		4 TYR A  25
PHE A  24
THR A  49
LEU A  53
 None
 1.30A 1ea1A-1vhmA:
undetectable		 1ea1A-1vhmA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpb PUTATIVE MODULATOR
OF DNA GYRASE

(Bacteroides
thetaiotaomicron) 		PF01523
(PmbA_TldD) 		4 TYR A 379
PHE A 365
PHE A 436
LEU A 407
 None
 1.21A 1ea1A-1vpbA:
undetectable		 1ea1A-1vpbA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 PHE A  78
MET A  79
ARG A  96
PHE A 255
 ESL  A 471 ( 4.9A)
ESL  A 471 ( 4.4A)
ESL  A 471 (-3.6A)
None
 0.80A 1ea1A-1x8vA:
61.2		 1ea1A-1x8vA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		6 TYR A  76
PHE A  78
MET A  79
PHE A 255
THR A 260
LEU A 321
 ESL  A 471 ( 3.8A)
ESL  A 471 ( 4.9A)
ESL  A 471 ( 4.4A)
None
HEM  A 470 (-3.6A)
HEM  A 470 (-4.1A)
 0.52A 1ea1A-1x8vA:
61.2		 1ea1A-1x8vA:
99.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 PHE A 326
MET A 325
THR A 171
LEU A 163
 None
 1.28A 1ea1A-1zgjA:
undetectable		 1ea1A-1zgjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2g PROTEIN
(ALPHA-2U-GLOBULIN)

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		4 TYR A  80
PHE A  90
THR A  95
LEU A  15
 None
LEO  A 201 ( 4.2A)
None
None
 1.09A 1ea1A-2a2gA:
undetectable		 1ea1A-2a2gA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 PHE A 243
MET A 411
PHE A 426
LEU A  71
 None
 1.26A 1ea1A-2aj4A:
undetectable		 1ea1A-2aj4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN

(Ovis aries) 		PF00230
(MIP) 		4 TYR A 204
PHE A 198
THR A 195
LEU A 118
 None
 1.20A 1ea1A-2b6oA:
undetectable		 1ea1A-2b6oA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		4 MET A 296
PHE A 333
THR A 277
LEU A 273
 None
 1.24A 1ea1A-2braA:
undetectable		 1ea1A-2braA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsi YOPT CHAPERONE SYCT

(Yersinia
enterocolitica) 		PF05932
(CesT) 		4 PHE A  13
MET A   9
PHE A   5
LEU A  50
 None
 1.28A 1ea1A-2bsiA:
undetectable		 1ea1A-2bsiA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 TYR A 163
PHE A 164
MET A 160
THR A  50
 None
 1.27A 1ea1A-2cgjA:
undetectable		 1ea1A-2cgjA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 PHE A 338
MET A 339
PHE A 729
LEU A 393
 None
 1.20A 1ea1A-2cvtA:
undetectable		 1ea1A-2cvtA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		4 TYR A 322
PHE A 325
THR A 344
LEU A 313
 None
 1.26A 1ea1A-2g28A:
undetectable		 1ea1A-2g28A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT

(Sphingobium
yanoikuyae) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 PHE A 147
MET A  40
PHE A 311
LEU A 168
 None
 1.23A 1ea1A-2gbxA:
undetectable		 1ea1A-2gbxA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdo PHOSPHOGLYCOLATE
PHOSPHATASE

(Lactobacillus
plantarum) 		PF13419
(HAD_2) 		4 TYR A 118
PHE A 120
MET A 121
THR A 104
 None
None
None
PO4  A 209 (-3.7A)
 0.87A 1ea1A-2hdoA:
undetectable		 1ea1A-2hdoA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		4 PHE A 652
MET A 678
THR A 648
LEU A 462
 None
 1.27A 1ea1A-2iutA:
undetectable		 1ea1A-2iutA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4e INOSINE TRIPHOSPHATE
PYROPHOSPHATASE

(Homo sapiens) 		PF01725
(Ham1p_like) 		4 TYR A 188
PHE A 132
THR A 122
LEU A   5
 None
 1.19A 1ea1A-2j4eA:
undetectable		 1ea1A-2j4eA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1e YCDH

(Bacillus
subtilis) 		PF01297
(ZnuA) 		4 TYR A 280
PHE A  29
PHE A  23
LEU A 131
 None
 1.17A 1ea1A-2o1eA:
undetectable		 1ea1A-2o1eA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojq PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF13949
(ALIX_LYPXL_bnd) 		4 TYR A 677
PHE A 676
ARG A 446
LEU A 499
 None
 0.97A 1ea1A-2ojqA:
undetectable		 1ea1A-2ojqA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pal PARVALBUMIN

(Esox lucius) 		PF13499
(EF-hand_7) 		4 PHE A  30
PHE A  24
THR A  82
LEU A  63
 None
 1.25A 1ea1A-2palA:
undetectable		 1ea1A-2palA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 TYR A 539
PHE A 422
THR A 555
LEU A 622
 None
 1.28A 1ea1A-2x2iA:
undetectable		 1ea1A-2x2iA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfx MHC CLASS 1

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 159
PHE A 156
ARG A  62
THR A  24
 None
 1.22A 1ea1A-2xfxA:
undetectable		 1ea1A-2xfxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 PHE B 422
MET B 384
PHE B 387
LEU B 398
 None
 1.27A 1ea1A-2y7cB:
undetectable		 1ea1A-2y7cB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 TYR A  97
PHE A 342
THR A 104
LEU A  57
 None
 1.29A 1ea1A-2y9xA:
undetectable		 1ea1A-2y9xA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3y O-METHYLTRANSFERASE

(Mesembryanthemum
crystallinum) 		PF01596
(Methyltransf_3) 		4 PHE A 232
PHE A 152
THR A  88
LEU A  66
 None
 1.27A 1ea1A-3c3yA:
undetectable		 1ea1A-3c3yA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cou NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 16

(Homo sapiens) 		PF00293
(NUDIX) 		4 PHE A  57
MET A  47
PHE A 158
LEU A 175
 None
 1.21A 1ea1A-3couA:
undetectable		 1ea1A-3couA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 290
MET A 267
PHE A 213
LEU A 220
 None
 1.18A 1ea1A-3dakA:
undetectable		 1ea1A-3dakA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 PHE A 531
PHE A 538
THR A 233
LEU A 398
 None
 1.12A 1ea1A-3dwbA:
undetectable		 1ea1A-3dwbA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0u GLUTATHIONE
PEROXIDASE

(Trypanosoma
cruzi) 		PF00255
(GSHPx) 		4 PHE A  75
MET A 106
THR A  71
LEU A  39
 NH4  A   1 (-4.7A)
None
None
None
 1.28A 1ea1A-3e0uA:
undetectable		 1ea1A-3e0uA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 TYR A 199
PHE A 200
MET A 196
LEU A 213
 None
 0.90A 1ea1A-3e53A:
undetectable		 1ea1A-3e53A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 TYR A 199
PHE A 200
MET A 196
PHE A 192
 None
 0.94A 1ea1A-3e53A:
undetectable		 1ea1A-3e53A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		4 TYR A 104
PHE A 186
MET A 106
THR A 387
 None
 1.17A 1ea1A-3fgqA:
undetectable		 1ea1A-3fgqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7q VALINE-PYRUVATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		4 TYR A  49
PHE A  50
MET A  46
ARG A 300
 None
 1.29A 1ea1A-3g7qA:
undetectable		 1ea1A-3g7qA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		4 TYR A  98
PHE A 124
ARG A  48
THR A 324
 None
 1.01A 1ea1A-3gveA:
undetectable		 1ea1A-3gveA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 PHE A 173
MET A  60
THR A 205
LEU A 198
 None
 0.92A 1ea1A-3gzyA:
undetectable		 1ea1A-3gzyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 PHE A 387
PHE A 381
THR A 334
LEU A 310
 None
 1.18A 1ea1A-3i2tA:
undetectable		 1ea1A-3i2tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		4 PHE A 562
ARG A 439
PHE A  89
THR A 205
 None
 1.27A 1ea1A-3i3lA:
undetectable		 1ea1A-3i3lA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 PHE A 118
MET A 114
THR A 142
LEU A 128
 None
 0.98A 1ea1A-3ig4A:
undetectable		 1ea1A-3ig4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2i ACYL-COENZYME A
THIOESTERASE 4

(Homo sapiens) 		PF04775
(Bile_Hydr_Trans)
PF08840
(BAAT_C) 		4 TYR A 190
PHE A 208
THR A 263
LEU A 233
 None
None
None
CL  A 423 ( 4.1A)
 1.22A 1ea1A-3k2iA:
undetectable		 1ea1A-3k2iA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		5 TYR A 102
MET A 105
PHE A 289
THR A 294
LEU A 355
 HEM  A 481 (-4.7A)
TPF  A 490 ( 4.0A)
TPF  A 490 (-4.3A)
TPF  A 490 ( 3.5A)
TPF  A 490 (-4.4A)
 0.91A 1ea1A-3l4dA:
37.1		 1ea1A-3l4dA:
32.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		4 TYR A 102
PHE A 104
MET A 105
PHE A 289
 HEM  A 481 (-4.7A)
None
TPF  A 490 ( 4.0A)
TPF  A 490 (-4.3A)
 0.92A 1ea1A-3l4dA:
37.1		 1ea1A-3l4dA:
32.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lx2 DNA POLYMERASE
SLIDING CLAMP 2

(Thermococcus
kodakarensis) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 PHE A  29
MET A  38
THR A  19
LEU A  16
 None
 1.18A 1ea1A-3lx2A:
undetectable		 1ea1A-3lx2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 TYR A  45
PHE A 218
MET A 221
THR A 108
 None
IMD  A 226 (-3.6A)
None
None
 1.28A 1ea1A-3mvuA:
undetectable		 1ea1A-3mvuA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER

(Pseudomonas
aeruginosa) 		PF12974
(Phosphonate-bd) 		4 TYR A 252
PHE A 270
PHE A  32
LEU A 265
 None
 1.21A 1ea1A-3n5lA:
undetectable		 1ea1A-3n5lA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzg PUTATIVE RACEMASE

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 212
PHE A 216
THR A 256
LEU A 226
 None
 1.31A 1ea1A-3nzgA:
undetectable		 1ea1A-3nzgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER

(Escherichia
coli) 		PF12974
(Phosphonate-bd) 		4 TYR A 228
PHE A 246
PHE A   9
LEU A 241
 None
 1.27A 1ea1A-3s4uA:
2.6		 1ea1A-3s4uA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5t DUF3298 FAMILY
PROTEIN

(Bacteroides
fragilis) 		PF11738
(DUF3298)
PF13739
(DUF4163) 		4 TYR A 265
MET A 268
PHE A 190
LEU A 237
 None
 1.07A 1ea1A-3s5tA:
undetectable		 1ea1A-3s5tA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8

(Homo sapiens) 		PF00076
(RRM_1)
PF13532
(2OG-FeII_Oxy_2) 		4 PHE A 333
MET A 224
THR A 329
LEU A 254
 None
 1.28A 1ea1A-3thtA:
undetectable		 1ea1A-3thtA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqx 2-AMINO-3-KETOBUTYRA
TE COENZYME A LIGASE

(Coxiella
burnetii) 		PF00155
(Aminotran_1_2) 		4 PHE A 317
MET A 312
PHE A 308
LEU A 344
 None
 1.03A 1ea1A-3tqxA:
undetectable		 1ea1A-3tqxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts3 CAPSID POLYPROTEIN

(Avastrovirus 3) 		PF16580
(Astro_capsid_p2) 		4 TYR A 542
PHE A 579
PHE A 491
LEU A 549
 None
 1.11A 1ea1A-3ts3A:
undetectable		 1ea1A-3ts3A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E

(Homo sapiens) 		PF00067
(p450) 		4 TYR A 464
PHE A 465
MET A 461
PHE A 457
 None
 1.10A 1ea1A-3v8dA:
29.7		 1ea1A-3v8dA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c47 INNER MEMBRANE
LIPOPROTEIN

(Salmonella
enterica) 		PF11622
(DUF3251) 		4 PHE A 145
MET A 172
THR A 184
LEU A 178
 None
 1.27A 1ea1A-4c47A:
undetectable		 1ea1A-4c47A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmo N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Bacillus cereus) 		PF00797
(Acetyltransf_2) 		4 TYR A 161
PHE A 186
THR A 114
LEU A 119
 None
 1.27A 1ea1A-4dmoA:
undetectable		 1ea1A-4dmoA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f47 ENOYL-COA HYDRATASE
ECHA19

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 MET A 190
ARG A 180
THR A 127
LEU A 163
 None
 1.19A 1ea1A-4f47A:
undetectable		 1ea1A-4f47A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Rickettsia
bellii) 		PF02350
(Epimerase_2) 		4 TYR A  41
PHE A  59
THR A   6
LEU A  32
 None
 1.24A 1ea1A-4hwgA:
undetectable		 1ea1A-4hwgA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 480
PHE A 184
THR A 173
LEU A 170
 None
 1.05A 1ea1A-4i8vA:
29.6		 1ea1A-4i8vA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbu VIRULENCE-ASSOCIATED
V ANTIGEN

(Yersinia pestis) 		PF04792
(LcrV) 		4 TYR A 312
PHE A 308
PHE A  78
LEU A 115
 None
 1.08A 1ea1A-4jbuA:
undetectable		 1ea1A-4jbuA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 TYR A 409
PHE A 408
PHE A 249
LEU A 215
 None
 1.28A 1ea1A-4l37A:
undetectable		 1ea1A-4l37A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 CALCIUM-BINDING
PROTEIN 39

(Homo sapiens) 		PF08569
(Mo25) 		4 TYR A 214
PHE A 210
THR A 193
LEU A 236
 None
 1.19A 1ea1A-4o27A:
undetectable		 1ea1A-4o27A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc8 RESTRICTION
ENDONUCLEASE ASPBHI

(Azoarcus sp.
BH72) 		PF04471
(Mrr_cat) 		4 TYR A  82
PHE A  80
ARG A  87
THR A 127
 None
 0.98A 1ea1A-4oc8A:
undetectable		 1ea1A-4oc8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqo SORTING NEXIN-14

(Homo sapiens) 		PF00787
(PX) 		4 TYR A 617
PHE A 589
PHE A 682
LEU A 639
 None
 1.24A 1ea1A-4pqoA:
undetectable		 1ea1A-4pqoA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ps6 INHIBITOR OF
VERTEBRATE LYSOZYME

(Pseudomonas
aeruginosa) 		PF08816
(Ivy) 		4 TYR A 131
PHE A  47
MET A  46
LEU A  93
 None
 1.12A 1ea1A-4ps6A:
undetectable		 1ea1A-4ps6A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0l T-CELL COSTIMULATORY
MOLECULE CD28

(Canis lupus) 		PF15910
(V-set_2) 		4 TYR C  54
PHE C  33
PHE C  60
THR C  78
 None
 1.28A 1ea1A-4r0lC:
undetectable		 1ea1A-4r0lC:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		4 PHE A 168
MET A 159
THR A 139
LEU A 137
 None
 1.26A 1ea1A-4rnzA:
undetectable		 1ea1A-4rnzA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqk LECTIN 2

(Agrocybe
aegerita) 		PF13517
(VCBS) 		4 MET A 399
PHE A 357
THR A 380
LEU A  39
 None
 1.12A 1ea1A-4tqkA:
undetectable		 1ea1A-4tqkA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3w 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 PHE A 457
PHE A 465
THR A 240
LEU A 169
 None
 1.10A 1ea1A-4u3wA:
undetectable		 1ea1A-4u3wA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)

(Candidatus
Korarchaeum
cryptofilum) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		4 PHE A 156
MET A 209
PHE A 284
LEU A 163
 None
 1.19A 1ea1A-4xz3A:
undetectable		 1ea1A-4xz3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		4 TYR A 242
PHE A 241
ARG A 388
LEU A 138
 None
 1.19A 1ea1A-5a08A:
undetectable		 1ea1A-5a08A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA

(Mycolicibacterium
smegmatis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A 299
MET A 297
PHE A 333
LEU A 363
 None
 1.27A 1ea1A-5ah4A:
undetectable		 1ea1A-5ah4A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp3 MYCOCEROSIC ACID
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF14765
(PS-DH) 		4 TYR A 947
MET A 950
THR A 980
LEU A 974
 None
 1.31A 1ea1A-5bp3A:
undetectable		 1ea1A-5bp3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cpr HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1

(Homo sapiens) 		PF00856
(SET) 		4 PHE B 189
MET B 188
THR B  97
LEU B  93
 None
 0.91A 1ea1A-5cprB:
2.2		 1ea1A-5cprB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csc CITRATE SYNTHASE

(Gallus gallus) 		PF00285
(Citrate_synt) 		4 MET B 176
PHE B  93
THR B  98
LEU B  10
 None
 1.26A 1ea1A-5cscB:
undetectable		 1ea1A-5cscB:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA

(Mycolicibacterium
thermoresistibile) 		no annotation 4 TYR C 222
MET C 175
PHE C 231
THR C 229
 None
 1.07A 1ea1A-5cw2C:
undetectable		 1ea1A-5cw2C:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezb CHICKEN PRESTIN STAS
DOMAIN,CHICKEN
PRESTIN STAS DOMAIN

(Gallus gallus) 		PF01740
(STAS) 		4 TYR A 514
PHE A 544
THR A 674
LEU A 550
 None
 1.17A 1ea1A-5ezbA:
undetectable		 1ea1A-5ezbA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 PHE A 337
MET A 402
PHE A 398
LEU A 288
 None
 1.25A 1ea1A-5fv4A:
undetectable		 1ea1A-5fv4A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		4 TYR A 501
PHE A 463
THR A  49
LEU A  53
 None
 1.18A 1ea1A-5glgA:
undetectable		 1ea1A-5glgA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 TYR A 307
PHE A 322
PHE A 295
THR A 779
 None
 1.25A 1ea1A-5im3A:
undetectable		 1ea1A-5im3A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 TYR A 592
PHE A 623
THR A 618
LEU A 614
 None
 1.14A 1ea1A-5j6sA:
undetectable		 1ea1A-5j6sA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		4 TYR A 127
PHE A 242
PHE A 237
LEU A 381
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.5A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 4.7A)
 1.29A 1ea1A-5jlcA:
33.1		 1ea1A-5jlcA:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC

(Mycobacterium
tuberculosis) 		PF01547
(SBP_bac_1) 		4 MET A 345
PHE A  58
THR A  72
LEU A  45
 None
 1.24A 1ea1A-5k2yA:
undetectable		 1ea1A-5k2yA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8n TYPE VI SECRETION
PROTEIN, FAMILY

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A 107
MET A 104
PHE A  70
LEU A  46
 None
 1.25A 1ea1A-5n8nA:
undetectable		 1ea1A-5n8nA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 4 TYR A  88
PHE A 100
MET A 103
THR A 141
 None
 1.24A 1ea1A-5na7A:
undetectable		 1ea1A-5na7A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 4 MET A 323
ARG A 337
PHE A 332
LEU A 286
 None
 1.30A 1ea1A-5oltA:
undetectable		 1ea1A-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Synechocystis
sp. PCC 6803) 		no annotation 4 MET b 129
PHE b 124
THR b  61
LEU b 142
 ECH  b1847 (-3.7A)
ECH  b1847 (-4.5A)
CLA  b1831 ( 3.3A)
ECH  b1847 ( 4.4A)
 1.21A 1ea1A-5oy0b:
undetectable		 1ea1A-5oy0b:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		4 PHE A 231
ARG A 302
THR A 247
LEU A 203
 None
 1.24A 1ea1A-5xd0A:
undetectable		 1ea1A-5xd0A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys6 PRV GLYCOPROTEN B

(Suid
alphaherpesvirus
1) 		no annotation 4 TYR A 293
PHE A 311
THR A 371
LEU A 421
 None
 0.93A 1ea1A-5ys6A:
undetectable		 1ea1A-5ys6A:
11.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 5 TYR A 107
MET A 110
PHE A 292
THR A 297
LEU A 358
 TPF  A 506 (-4.2A)
TPF  A 506 (-4.6A)
TPF  A 506 ( 4.0A)
HEM  A 501 (-3.4A)
TPF  A 506 ( 4.4A)
 0.74A 1ea1A-6ay4A:
40.4		 1ea1A-6ay4A:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 4 TYR A 107
PHE A 109
MET A 110
PHE A 292
 TPF  A 506 (-4.2A)
None
TPF  A 506 (-4.6A)
TPF  A 506 ( 4.0A)
 0.94A 1ea1A-6ay4A:
40.4		 1ea1A-6ay4A:
32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co1 TUDOR-INTERACTING
REPAIR REGULATOR
PROTEIN

(Homo sapiens) 		no annotation 4 PHE A  62
MET A  52
PHE A 160
LEU A 177
 None
 1.12A 1ea1A-6co1A:
undetectable		 1ea1A-6co1A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co2 NUDT16-TUDOR-INTERAC
TING (NUDT16TI)

(Homo sapiens) 		no annotation 4 PHE A  57
MET A  47
PHE A 159
LEU A 176
 None
 1.21A 1ea1A-6co2A:
undetectable		 1ea1A-6co2A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d47 BETA SLIDING CLAMP

(Mycobacterium
marinum) 		no annotation 4 PHE A 301
MET A 299
PHE A 335
LEU A 365
 None
 1.28A 1ea1A-6d47A:
undetectable		 1ea1A-6d47A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 TYR B 475
ARG B 217
PHE B 105
THR B 259
 None
 1.26A 1ea1A-6f0kB:
undetectable		 1ea1A-6f0kB:
11.26