SIMILAR PATTERNS OF AMINO ACIDS FOR 1E7W_A_MTXA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ai1 IGG1-KAPPA 59.1 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG H  66
SER H  60
LEU H  20
LEU H  18
ASP H  86
 None
 1.40A 1e7wA-1ai1H:
undetectable		 1e7wA-1ai1H:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c12 PROTEIN (ANTIBODY
FRAGMENT FAB)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG B 366
SER B 362
LEU B 380
LEU B 318
ASP B 386
 None
 1.40A 1e7wA-1c12B:
undetectable		 1e7wA-1c12B:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 ARG 1 248
LEU 1 309
LEU 1 302
LEU 1 188
ASP 1 252
 None
 1.20A 1e7wA-1gt91:
2.2		 1e7wA-1gt91:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 ARG 1 248
SER 1 229
LEU 1 302
LEU 1 188
ASP 1 252
 None
 1.29A 1e7wA-1gt91:
2.2		 1e7wA-1gt91:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 PHE A 526
TYR A 320
LEU A 377
LEU A 409
ASP A 412
 None
 1.29A 1e7wA-1gz7A:
1.5		 1e7wA-1gz7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv3 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Thermus
thermophilus) 		PF02542
(YgbB) 		5 PRO A  26
ASP A  38
LEU A  23
LEU A 116
LEU A 129
 None
 1.43A 1e7wA-1iv3A:
undetectable		 1e7wA-1iv3A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		5 PHE A 656
LEU A 423
TYR A 432
LEU A 551
ASP A 554
 None
 1.44A 1e7wA-1k1xA:
undetectable		 1e7wA-1k1xA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0w GLUTATHIONE
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		5 LEU A 490
TYR A 491
LEU A 443
LEU A 466
ASP A 486
 None
 1.43A 1e7wA-1m0wA:
undetectable		 1e7wA-1m0wA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 SER B 316
PHE B 422
LEU B 309
LEU B 499
LEU B 512
 None
 1.40A 1e7wA-1m2vB:
2.4		 1e7wA-1m2vB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 SER A 492
PRO A 473
LEU A 314
TYR A 315
MET A 263
 None
 1.43A 1e7wA-1mroA:
undetectable		 1e7wA-1mroA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw5 HYPOTHETICAL PROTEIN
HI1480

(Haemophilus
influenzae) 		no annotation 5 SER A 130
PHE A 131
LEU A  73
LEU A  92
LEU A  96
 None
 1.37A 1e7wA-1mw5A:
undetectable		 1e7wA-1mw5A:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		8 ARG A  22
SER A 103
PRO A 107
ASP A 169
LEU A 176
TYR A 182
LEU A 214
LEU A 217
 NDP  A1277 ( 3.9A)
MTX  A1278 ( 2.7A)
None
NDP  A1277 (-3.9A)
MTX  A1278 (-4.5A)
MTX  A1278 ( 4.7A)
MTX  A1278 (-4.4A)
None
 0.77A 1e7wA-1mxfA:
40.6		 1e7wA-1mxfA:
48.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		8 ARG A  22
SER A 103
PRO A 107
ASP A 169
LEU A 176
TYR A 182
LEU A 217
MET A 221
 NDP  A1277 ( 3.9A)
MTX  A1278 ( 2.7A)
None
NDP  A1277 (-3.9A)
MTX  A1278 (-4.5A)
MTX  A1278 ( 4.7A)
None
MTX  A1278 (-4.6A)
 0.65A 1e7wA-1mxfA:
40.6		 1e7wA-1mxfA:
48.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		5 SER A 103
PRO A 107
LEU A 176
TYR A 182
LEU A 214
 MTX  A1278 ( 2.7A)
None
MTX  A1278 (-4.5A)
MTX  A1278 ( 4.7A)
MTX  A1278 (-4.4A)
 1.22A 1e7wA-1mxfA:
40.6		 1e7wA-1mxfA:
48.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		11 ARG A  17
SER A 111
PHE A 113
PRO A 115
ASP A 181
LEU A 188
TYR A 191
TYR A 194
LEU A 226
LEU A 229
MET A 233
 NDP  A 300 ( 3.7A)
MTX  A 351 ( 2.8A)
MTX  A 351 (-3.5A)
MTX  A 351 (-4.2A)
NDP  A 300 ( 3.7A)
MTX  A 351 (-4.5A)
MTX  A 351 (-4.8A)
MTX  A 351 ( 4.4A)
MTX  A 351 ( 4.4A)
MTX  A 351 (-4.9A)
MTX  A 351 ( 4.8A)
 0.54A 1e7wA-1p33A:
44.8		 1e7wA-1p33A:
79.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		6 SER A 111
PHE A 113
PRO A 115
TYR A 191
TYR A 194
LEU A 226
 MTX  A 351 ( 2.8A)
MTX  A 351 (-3.5A)
MTX  A 351 (-4.2A)
MTX  A 351 (-4.8A)
MTX  A 351 ( 4.4A)
MTX  A 351 ( 4.4A)
 0.93A 1e7wA-1p33A:
44.8		 1e7wA-1p33A:
79.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 SER A 316
PHE A 422
LEU A 309
LEU A 499
LEU A 512
 None
 1.38A 1e7wA-1pd1A:
2.3		 1e7wA-1pd1A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttz CONSERVED
HYPOTHETICAL PROTEIN

(Xanthomonas
campestris) 		PF05768
(DUF836) 		5 ARG A  57
LEU A   5
LEU A  68
LEU A  72
ASP A  53
 None
 1.31A 1e7wA-1ttzA:
undetectable		 1e7wA-1ttzA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 ARG B 456
LEU B 414
LEU B 437
LEU B 445
ASP B 389
 None
 1.44A 1e7wA-1wytB:
2.1		 1e7wA-1wytB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj3 FAB M18, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG B  66
PRO B  41
LEU B  20
LEU B  18
ASP B  86
 None
 1.29A 1e7wA-2aj3B:
undetectable		 1e7wA-2aj3B:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PRO A 298
LEU A 285
LEU A 269
LEU A 236
ASP A 217
 NAD  A1403 (-4.8A)
None
None
NAD  A1403 (-4.7A)
NAD  A1403 (-2.9A)
 1.40A 1e7wA-2dphA:
7.9		 1e7wA-2dphA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f58 PROTEIN (IGG1 FAB
58.2 ANTIBODY (HEAVY
CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG H  66
PRO H  41
LEU H  20
LEU H  18
ASP H  86
 None
 1.12A 1e7wA-2f58H:
undetectable		 1e7wA-2f58H:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG H  68
PRO H  43
LEU H  20
LEU H  18
ASP H  91
 None
 1.31A 1e7wA-2f5aH:
undetectable		 1e7wA-2f5aH:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1

(Trypanosoma
brucei) 		PF09387
(MRP) 		5 PHE B 118
LEU B 154
TYR B 125
LEU B  56
LEU B  93
 None
 1.30A 1e7wA-2gidB:
undetectable		 1e7wA-2gidB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsz NOVEL PREDICTED
PHOSPHATASE

(Histophilus
somni) 		PF13419
(HAD_2) 		5 SER A  18
ASP A  10
LEU A 194
TYR A 196
LEU A 104
 None
 1.39A 1e7wA-2hszA:
5.9		 1e7wA-2hszA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Saccharomyces
cerevisiae) 		PF03770
(IPK) 		5 PHE A 219
LEU A 130
TYR A 218
LEU A 348
LEU A 240
 None
 1.16A 1e7wA-2iewA:
undetectable		 1e7wA-2iewA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kom PARTITIONING
DEFECTIVE 3 HOMOLOG

(Homo sapiens) 		PF00595
(PDZ) 		5 PRO A 487
LEU A 519
LEU A 542
LEU A 505
ASP A 509
 None
 1.27A 1e7wA-2komA:
undetectable		 1e7wA-2komA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mv7 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC
PROTEIN AF-9

(Homo sapiens) 		no annotation 5 PHE A 545
PRO B 880
LEU A 547
LEU A 562
LEU A 517
 None
 1.44A 1e7wA-2mv7A:
undetectable		 1e7wA-2mv7A:
13.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		10 ARG A  17
SER A 111
PHE A 113
PRO A 115
ASP A 181
LEU A 188
TYR A 191
TYR A 194
LEU A 226
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
None
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
None
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
 0.23A 1e7wA-2qhxA:
45.3		 1e7wA-2qhxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans) 		PF14514
(TetR_C_9) 		5 SER A 175
LEU A 114
LEU A  67
ASP A  70
MET A  71
 GOL  A 225 (-3.9A)
None
None
None
None
 1.43A 1e7wA-2rhaA:
undetectable		 1e7wA-2rhaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE

(Staphylococcus
aureus) 		PF00884
(Sulfatase) 		5 ARG A 563
PHE A 547
LEU A 545
LEU A 613
ASP A 610
 None
 1.32A 1e7wA-2w5sA:
undetectable		 1e7wA-2w5sA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7l FAB HEAVY CHAIN

(unidentified) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG A  67
PRO A  41
LEU A  20
LEU A  81
ASP A  88
 None
 1.34A 1e7wA-2x7lA:
undetectable		 1e7wA-2x7lA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5q INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 SER A  49
PHE A  53
LEU A 105
LEU A 116
LEU A 119
 None
 1.36A 1e7wA-2y5qA:
undetectable		 1e7wA-2y5qA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		5 SER A  93
PHE A  94
TYR A  81
LEU A 130
LEU A 151
 None
 1.22A 1e7wA-3alfA:
undetectable		 1e7wA-3alfA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9k FAB HEAVY CHAIN

(Rattus rattus) 		no annotation 5 ARG H  66
PRO H  41
LEU H  20
LEU H  18
ASP H  86
 None
 1.28A 1e7wA-3b9kH:
undetectable		 1e7wA-3b9kH:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9v HEAVY CHAIN VARIABLE
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		5 PRO A  41
LEU A 108
LEU A  18
LEU A  82
ASP A  86
 None
 1.26A 1e7wA-3b9vA:
undetectable		 1e7wA-3b9vA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwn L-TRYPTOPHAN
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF04864
(Alliinase_C) 		5 PHE A 279
TYR A  35
TYR A  38
LEU A 263
LEU A  80
 None
 1.23A 1e7wA-3bwnA:
undetectable		 1e7wA-3bwnA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1o EUGENOL SYNTHASE

(Clarkia breweri) 		PF05368
(NmrA) 		5 PHE A 304
PRO A 310
LEU A 300
LEU A 224
LEU A 161
 None
 1.34A 1e7wA-3c1oA:
13.8		 1e7wA-3c1oA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		5 ARG A 272
PRO A 171
LEU A 106
TYR A 169
ASP A  90
 None
 1.37A 1e7wA-3c4nA:
3.6		 1e7wA-3c4nA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF01636
(APH) 		5 PRO A 129
LEU A  68
TYR A  67
LEU A 119
LEU A 120
 None
None
EDO  A 346 (-4.3A)
None
None
 1.25A 1e7wA-3csvA:
undetectable		 1e7wA-3csvA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 PRO A 586
LEU A 596
LEU A 698
LEU A 112
MET A 115
 None
 1.31A 1e7wA-3dwbA:
undetectable		 1e7wA-3dwbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eea GAF DOMAIN/HD DOMAIN
PROTEIN

(Geobacter
sulfurreducens) 		PF13492
(GAF_3) 		5 PHE A 125
LEU A  75
TYR A  37
LEU A  96
LEU A  87
 PG6  A 163 ( 4.2A)
PG6  A 163 ( 4.8A)
None
None
None
 1.35A 1e7wA-3eeaA:
undetectable		 1e7wA-3eeaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzu IMMUNOGLOBULIN IGG1
FAB, HEAVY CHAIN

(Homo sapiens) 		no annotation 5 PRO H  43
LEU H 113
LEU H  18
LEU H  88
ASP H  92
 None
 1.06A 1e7wA-3fzuH:
undetectable		 1e7wA-3fzuH:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge4 DNA PROTECTION
DURING STARVATION
PROTEIN

(Brucella
melitensis) 		PF00210
(Ferritin) 		5 ARG A 126
SER A 128
LEU A  66
LEU A 155
ASP A 152
 None
 1.35A 1e7wA-3ge4A:
undetectable		 1e7wA-3ge4A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go1 FAB 268-D, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG H  66
SER H  62
LEU H  80
LEU H  18
ASP H  86
 None
 1.43A 1e7wA-3go1H:
undetectable		 1e7wA-3go1H:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)

(Homo sapiens) 		PF00702
(Hydrolase) 		5 PHE A 350
LEU A 345
TYR A 348
LEU A 325
ASP A 324
 None
 1.35A 1e7wA-3hb0A:
2.7		 1e7wA-3hb0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 SER A 375
PHE A 361
LEU A 402
LEU A 394
MET A 387
 None
 1.26A 1e7wA-3k28A:
undetectable		 1e7wA-3k28A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		5 PHE A 405
TYR A 367
TYR A 355
LEU A 387
LEU A 446
 None
 1.24A 1e7wA-3k8kA:
undetectable		 1e7wA-3k8kA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7f H2L6 HEAVY CHAIN

(Homo sapiens) 		no annotation 5 ARG H  68
PRO H  43
LEU H  20
LEU H  18
ASP H  91
 None
 1.44A 1e7wA-3l7fH:
undetectable		 1e7wA-3l7fH:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PRO A 141
LEU A 193
TYR A 156
LEU A 229
ASP A 206
 None
None
None
None
MG  A1243 (-3.3A)
 1.41A 1e7wA-3mqtA:
undetectable		 1e7wA-3mqtA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9w HUMAN VEGF

(Homo sapiens) 		PF07686
(V-set) 		5 PRO B  41
LEU B 108
LEU B  18
LEU B  82
ASP B  86
 PRO  B  41 ( 1.1A)
LEU  B 108 ( 0.6A)
LEU  B  18 ( 0.5A)
LEU  B  82 ( 0.5A)
ASP  B  86 ( 0.5A)
 1.26A 1e7wA-3p9wB:
undetectable		 1e7wA-3p9wB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		5 ARG A1240
PHE A1202
PRO A1204
TYR A1172
LEU A1154
 None
 1.42A 1e7wA-3pvlA:
undetectable		 1e7wA-3pvlA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhf HUMAN MONOCLONAL
ANTIBODY DEL2D1,
FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG H  66
PRO H  41
LEU H  20
LEU H  18
ASP H  86
 None
 1.36A 1e7wA-3qhfH:
undetectable		 1e7wA-3qhfH:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slr UNCHARACTERIZED
PROTEIN BF1531

(Bacteroides
fragilis) 		no annotation 5 PRO A 357
LEU A 367
LEU A 225
LEU A 227
ASP A 228
 None
None
None
None
MG  A 388 ( 2.7A)
 1.41A 1e7wA-3slrA:
7.6		 1e7wA-3slrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 5 PRO A 157
LEU A 166
TYR A 222
LEU A 139
MET A 201
 None
 1.43A 1e7wA-3tdgA:
undetectable		 1e7wA-3tdgA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Lactobacillus
acidophilus) 		PF00215
(OMPdecase) 		5 PRO A  27
LEU A  50
TYR A  55
LEU A  38
LEU A  11
 None
 0.92A 1e7wA-3tfxA:
undetectable		 1e7wA-3tfxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		5 PRO A 141
LEU A 118
LEU A 218
LEU A 132
MET A 133
 None
 1.36A 1e7wA-3wrtA:
undetectable		 1e7wA-3wrtA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN

(Escherichia
coli;
Mus musculus) 		PF07679
(I-set)
PF13416
(SBP_bac_8) 		5 PHE A  86
PRO A  82
LEU A  90
LEU A 291
LEU A 285
 None
 1.33A 1e7wA-4edqA:
undetectable		 1e7wA-4edqA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6k HEAVY CHAIN OF
GEVOKIZUMAB ANTIBODY
BINDING FRAGMENT

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG H  68
SER H  64
LEU H  20
LEU H  18
ASP H  91
 None
 1.24A 1e7wA-4g6kH:
undetectable		 1e7wA-4g6kH:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqp ANTI-METH SCFV

(Mus musculus) 		PF07686
(V-set) 		5 ARG H  66
PRO H  41
LEU H  20
LEU H  18
ASP H  86
 None
 1.34A 1e7wA-4gqpH:
undetectable		 1e7wA-4gqpH:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG H  68
PRO H  43
LEU H  20
LEU H  18
ASP H  91
 None
 1.36A 1e7wA-4hjjH:
undetectable		 1e7wA-4hjjH:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inf METAL-DEPENDENT
HYDROLASE

(Novosphingobium
aromaticivorans) 		PF04909
(Amidohydro_2) 		5 SER A 282
PHE A 229
LEU A 223
LEU A 185
LEU A 178
 None
 1.38A 1e7wA-4infA:
undetectable		 1e7wA-4infA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlr MOTAVIZUMAB FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 ARG H  66
PRO H  41
LEU H  20
LEU H  18
ASP H  86
 None
 1.32A 1e7wA-4jlrH:
undetectable		 1e7wA-4jlrH:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jy4 PGT121 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG B  66
SER B  60
LEU B  20
LEU B  18
ASP B  86
 None
 1.36A 1e7wA-4jy4B:
undetectable		 1e7wA-4jy4B:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG H  66
PRO H  41
LEU H  20
LEU H  18
ASP H  86
 None
 1.28A 1e7wA-4k3dH:
undetectable		 1e7wA-4k3dH:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 ARG H  66
PRO H  41
LEU H  20
LEU H  18
ASP H  86
 None
 1.33A 1e7wA-4laqH:
undetectable		 1e7wA-4laqH:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lar SINGLE HEAVY CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 ARG H  66
PRO H  41
LEU H  20
LEU H  18
ASP H  86
 None
 1.37A 1e7wA-4larH:
undetectable		 1e7wA-4larH:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9r CELL DEATH PROTEIN 3

(Caenorhabditis
elegans) 		PF00656
(Peptidase_C14) 		5 SER A 307
PRO A 496
LEU A 272
TYR A 278
LEU A 458
 None
 1.32A 1e7wA-4m9rA:
5.0		 1e7wA-4m9rA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		5 ASP A 475
LEU A 388
TYR A 390
TYR A 350
ASP A 358
 None
 1.29A 1e7wA-4qlbA:
4.6		 1e7wA-4qlbA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Homo sapiens) 		PF01704
(UDPGP) 		5 PHE A 446
LEU A 432
TYR A 442
LEU A 455
LEU A 472
 None
 1.36A 1e7wA-4r7pA:
undetectable		 1e7wA-4r7pA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 PRO D  41
LEU D 119
LEU D  18
LEU D  86
ASP D  90
 None
 1.14A 1e7wA-4v1dD:
undetectable		 1e7wA-4v1dD:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbp CAPRIN-1

(Homo sapiens) 		no annotation 5 ARG A 165
SER A 179
LEU A 233
LEU A 156
ASP A 187
 None
 1.40A 1e7wA-4wbpA:
undetectable		 1e7wA-4wbpA:
15.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wcd PTERIDINE REDUCTASE

(Trypanosoma
brucei) 		PF13561
(adh_short_C2) 		8 ARG A  14
SER A  95
PHE A  97
PRO A  99
ASP A 161
TYR A 174
LEU A 209
MET A 213
 NAP  A 301 (-3.7A)
NAP  A 301 ( 3.1A)
3KH  A 302 (-3.5A)
None
NAP  A 301 ( 3.8A)
3KH  A 302 ( 4.7A)
None
None
 0.55A 1e7wA-4wcdA:
41.2		 1e7wA-4wcdA:
48.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wcd PTERIDINE REDUCTASE

(Trypanosoma
brucei) 		PF13561
(adh_short_C2) 		5 SER A  95
PHE A  97
PRO A  99
TYR A 174
LEU A 209
 NAP  A 301 ( 3.1A)
3KH  A 302 (-3.5A)
None
3KH  A 302 ( 4.7A)
None
 1.13A 1e7wA-4wcdA:
41.2		 1e7wA-4wcdA:
48.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		5 ARG A 245
LEU A 169
LEU A  78
ASP A  81
MET A  82
 None
 1.29A 1e7wA-4zmhA:
undetectable		 1e7wA-4zmhA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		5 ARG A 245
LEU A 192
LEU A 169
LEU A  78
ASP A  81
 None
 1.18A 1e7wA-4zmhA:
undetectable		 1e7wA-4zmhA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 ARG A 144
PHE A  63
LEU A  18
LEU A  35
LEU A  91
 GOL  A3001 (-3.5A)
None
None
None
GOL  A3001 (-4.5A)
 1.22A 1e7wA-4ztxA:
undetectable		 1e7wA-4ztxA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhz ANTI-REV ANTIBODY
FAB SINGLE-CHAIN
VARIABLE FRAGMENT,
HEAVY CHAIN

(Oryctolagus
cuniculus) 		PF07686
(V-set) 		5 ARG H  67
PRO H  41
LEU H  79
LEU H  81
ASP H  88
 None
 1.42A 1e7wA-5dhzH:
undetectable		 1e7wA-5dhzH:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e94 ANTIBODY FAB
FRAGMENT HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG B  67
PRO B  42
LEU B  20
LEU B  18
ASP B  90
 None
 1.13A 1e7wA-5e94B:
undetectable		 1e7wA-5e94B:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS

(Mus musculus) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		5 PHE C 437
PRO C 432
LEU C  66
ASP C 414
MET C  62
 None
 1.41A 1e7wA-5eg6C:
undetectable		 1e7wA-5eg6C:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT

(Escherichia
coli) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 SER B 243
LEU B  91
TYR B 228
LEU B 113
LEU B 190
 None
 1.31A 1e7wA-5g5gB:
undetectable		 1e7wA-5g5gB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 SER A 490
LEU A 519
LEU A 500
LEU A 428
ASP A 427
 NAG  A 902 (-3.7A)
None
None
None
SO4  A 920 (-4.5A)
 1.42A 1e7wA-5gmhA:
undetectable		 1e7wA-5gmhA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 5 PRO B  37
LEU B 426
TYR B  39
LEU B 464
LEU B 530
 None
 1.20A 1e7wA-5i61B:
undetectable		 1e7wA-5i61B:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw6 DDB_G0293866

(Dictyostelium
discoideum) 		no annotation 5 SER A 116
LEU A 145
TYR A 146
LEU A 166
LEU A 160
 None
 1.20A 1e7wA-5lw6A:
undetectable		 1e7wA-5lw6A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly3 ACTIN/ACTIN FAMILY
PROTEIN

(Pyrobaculum
calidifontis) 		PF00022
(Actin) 		5 ARG A   9
PHE A 429
PRO A 430
LEU A 417
LEU A 413
 None
 1.26A 1e7wA-5ly3A:
undetectable		 1e7wA-5ly3A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		5 ARG A 875
PHE A 830
PRO A 821
LEU A 706
ASP A 683
 None
 1.06A 1e7wA-5mqmA:
undetectable		 1e7wA-5mqmA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o14 FAB 1A12 HEAVY CHAIN

(Homo sapiens) 		no annotation 5 ARG C  67
PRO C  41
LEU C  18
LEU C  86
ASP C  90
 None
 1.05A 1e7wA-5o14C:
undetectable		 1e7wA-5o14C:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4z ANTIBODY DH501 FAB
HEAVY CHAIN

(Macaca mulatta) 		no annotation 5 ARG H  66
PRO H  41
LEU H  20
LEU H  18
ASP H  86
 None
 1.32A 1e7wA-5t4zH:
undetectable		 1e7wA-5t4zH:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE

(Brucella suis) 		PF00106
(adh_short) 		5 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.53A 1e7wA-5tgdA:
30.7		 1e7wA-5tgdA:
31.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		5 PRO A1198
LEU A1195
LEU A1326
LEU A1344
ASP A1343
 None
 1.26A 1e7wA-5u1sA:
undetectable		 1e7wA-5u1sA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 ARG A 299
SER A 325
TYR A 268
LEU A 285
LEU A 277
 None
UDP  A 503 (-3.1A)
None
None
None
 1.44A 1e7wA-5u6sA:
5.4		 1e7wA-5u6sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		5 ARG A 266
PHE A 299
TYR A 327
TYR A 131
MET A 183
 LLP  A 184 ( 4.7A)
None
LLP  A 184 ( 4.3A)
None
None
 1.34A 1e7wA-5uidA:
undetectable		 1e7wA-5uidA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 SER A 140
ASP A 614
LEU A 612
TYR A 146
LEU A  86
 None
 1.29A 1e7wA-5x7hA:
undetectable		 1e7wA-5x7hA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aliivibrio
fischeri) 		no annotation 5 PRO A  41
LEU A 316
TYR A 317
LEU A 334
LEU A 270
 None
 1.42A 1e7wA-5xi0A:
17.7		 1e7wA-5xi0A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwd VH CHAIN OF 059-152

(Homo sapiens) 		no annotation 5 PRO H  43
LEU H 115
LEU H  20
LEU H  18
ASP H  91
 None
 1.37A 1e7wA-5xwdH:
undetectable		 1e7wA-5xwdH:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yax SCFV1 ANTIBODY

(Homo sapiens) 		no annotation 5 ARG A  75
PRO A  46
LEU A  21
LEU A  19
ASP A  98
 None
 1.24A 1e7wA-5yaxA:
undetectable		 1e7wA-5yaxA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 5 ARG A  62
ASP A 162
TYR A 135
TYR A 169
ASP A 110
 None
 1.33A 1e7wA-5ykbA:
undetectable		 1e7wA-5ykbA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6be3 FAB (F598) HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 ARG H  66
PRO H  41
LEU H  20
LEU H  18
ASP H  89
 None
 1.39A 1e7wA-6be3H:
undetectable		 1e7wA-6be3H:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 5 PHE A 488
PRO A 491
LEU A  70
TYR A  64
LEU A 397
 None
 1.16A 1e7wA-6dk2A:
undetectable		 1e7wA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg8 SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		no annotation 5 ASP A 123
LEU A 148
TYR A 125
LEU A 143
LEU A 167
 None
 1.43A 1e7wA-6fg8A:
undetectable		 1e7wA-6fg8A:
17.37