SIMILAR PATTERNS OF AMINO ACIDS FOR 1E7C_A_HLTA4007_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdr FLAVODOXIN REDUCTASE

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A  67
ASN A  14
LEU A  82
LEU A  22
 FAD  A 249 (-4.5A)
None
None
None
 0.98A 1e7cA-1fdrA:
undetectable		 1e7cA-1fdrA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A 135
ASP A 199
LEU A 198
LEU A 174
 None
 0.99A 1e7cA-1hjvA:
undetectable		 1e7cA-1hjvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		4 LEU A 610
PHE A 578
LEU A 617
LEU A 614
 None
 1.05A 1e7cA-1j1wA:
2.3		 1e7cA-1j1wA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		4 LEU A 113
HIS A 110
LEU A  76
LEU A  79
 None
 1.06A 1e7cA-1j33A:
undetectable		 1e7cA-1j33A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		4 LEU A   5
HIS A   6
ASP A 257
LEU A 256
 None
 0.78A 1e7cA-1k8qA:
0.0		 1e7cA-1k8qA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9s INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF09479
(Flg_new)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13457
(SH3_8) 		4 LEU A 169
ASP A 189
LEU A 210
LEU A 188
 None
 0.95A 1e7cA-1m9sA:
undetectable		 1e7cA-1m9sA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhm S-ADENOSYLMETHIONINE
DECARBOXYLASE

(Solanum
tuberosum) 		PF01536
(SAM_decarbox) 		4 LEU B  70
ASP B  46
LEU B  45
LEU B  49
 PYR  A  73 ( 4.1A)
None
None
None
 0.94A 1e7cA-1mhmB:
undetectable		 1e7cA-1mhmB:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1j HEMOGLOBIN ALPHA
CHAIN

(Homo sapiens) 		PF00042
(Globin) 		4 LEU A 247
ASP A 268
LEU A 267
LEU A 271
 None
 1.07A 1e7cA-1o1jA:
2.6		 1e7cA-1o1jA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t71 PHOSPHATASE

(Mycoplasma
pneumoniae) 		PF13277
(YmdB) 		4 LEU A 141
PHE A 138
ASN A 136
LEU A 123
 None
 0.93A 1e7cA-1t71A:
undetectable		 1e7cA-1t71A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 LEU A 309
ASN A  85
LEU A  93
LEU A  94
 None
 1.02A 1e7cA-1tufA:
0.0		 1e7cA-1tufA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 LEU A 528
HIS A 527
ASN A 650
LEU A 641
 None
 1.05A 1e7cA-1w27A:
1.9		 1e7cA-1w27A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		4 LEU C 564
PHE C 483
LEU C 571
LEU C 568
 None
 0.96A 1e7cA-1w36C:
2.2		 1e7cA-1w36C:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		4 LEU C 432
ASN C 435
LEU C 449
LEU C 450
 None
 1.02A 1e7cA-1wa5C:
2.5		 1e7cA-1wa5C:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Pyrococcus
horikoshii) 		PF03483
(B3_4)
PF03484
(B5) 		4 LEU A 112
ASP A 115
LEU A 119
LEU A 114
 None
 1.08A 1e7cA-2cxiA:
undetectable		 1e7cA-2cxiA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 LEU A 199
PHE A 203
LEU A 236
LEU A 235
 None
 0.79A 1e7cA-2dkdA:
2.3		 1e7cA-2dkdA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B

(Homo sapiens) 		PF14580
(LRR_9) 		4 LEU A  31
ASN A  58
LEU A  61
LEU A  56
 None
 0.98A 1e7cA-2ellA:
undetectable		 1e7cA-2ellA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exh BETA-D-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43) 		4 HIS A 341
ASN A 340
ASP A 327
LEU A  51
 MES  A2005 (-3.9A)
None
None
MES  A2005 ( 4.7A)
 0.95A 1e7cA-2exhA:
undetectable		 1e7cA-2exhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 255
HIS A 258
ASP A 270
LEU A 271
 None
 0.91A 1e7cA-2f9qA:
3.1		 1e7cA-2f9qA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933

(Haemophilus
influenzae) 		PF03486
(HI0933_like) 		4 TYR A 229
LEU A 261
ASN A 264
LEU A 216
 None
 0.64A 1e7cA-2gqfA:
undetectable		 1e7cA-2gqfA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A

(Homo sapiens) 		PF14580
(LRR_9) 		4 LEU A  44
PHE A  46
LEU A  69
LEU A  66
 None
 0.94A 1e7cA-2je1A:
undetectable		 1e7cA-2je1A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		4 LEU A 463
ASP A 125
LEU A 124
LEU A 128
 None
 0.95A 1e7cA-2oodA:
undetectable		 1e7cA-2oodA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk2 LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		4 LEU A 394
ASN A 433
LEU A 439
LEU A 440
 None
 1.07A 1e7cA-2qk2A:
undetectable		 1e7cA-2qk2A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvs CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT

(Mus musculus) 		PF00027
(cNMP_binding) 		4 ASN B 240
ASP B 140
LEU B 144
LEU B 139
 ASN  B 240 ( 0.6A)
ASP  B 140 ( 0.5A)
LEU  B 144 ( 0.6A)
LEU  B 139 ( 0.6A)
 1.00A 1e7cA-2qvsB:
undetectable		 1e7cA-2qvsB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 325
ASN A 225
LEU A 230
LEU A 231
 None
 1.02A 1e7cA-2qyvA:
undetectable		 1e7cA-2qyvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 HIS A  43
ASP A 282
LEU A 283
LEU A 284
 None
 1.08A 1e7cA-2r9lA:
undetectable		 1e7cA-2r9lA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 381
ASN A 408
LEU A 414
LEU A 419
 None
 0.96A 1e7cA-2vosA:
3.5		 1e7cA-2vosA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 362
PHE A 364
LEU A 392
LEU A 389
 None
 0.88A 1e7cA-2z81A:
undetectable		 1e7cA-2z81A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpk FERREDOXIN-NADP
REDUCTASE

(Salmonella
enterica) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A  67
ASN A  14
LEU A  82
LEU A  22
 FAD  A 301 (-4.1A)
None
None
None
 0.91A 1e7cA-3fpkA:
undetectable		 1e7cA-3fpkA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT

(Mus musculus) 		PF00027
(cNMP_binding)
PF02197
(RIIa) 		4 ASN B 242
ASP B 142
LEU B 146
LEU B 141
 None
 1.01A 1e7cA-3j4rB:
undetectable		 1e7cA-3j4rB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9h PF-32 PROTEIN

(Borreliella
burgdorferi) 		PF13614
(AAA_31) 		4 LEU A 143
ASP A 136
LEU A 135
LEU A 139
 None
 1.07A 1e7cA-3k9hA:
undetectable		 1e7cA-3k9hA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhq ACRAB OPERON
REPRESSOR (TETR/ACRR
FAMILY)

(Salmonella
enterica) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 LEU A 109
ASP A  18
LEU A  17
LEU A  21
 None
 1.01A 1e7cA-3lhqA:
3.5		 1e7cA-3lhqA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		4 LEU A  46
HIS A  47
LEU A  28
LEU A  32
 None
 0.76A 1e7cA-3lomA:
2.6		 1e7cA-3lomA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lul 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Legionella
pneumophila) 		PF01063
(Aminotran_4) 		4 LEU A 205
HIS A 208
ASP A 269
LEU A 266
 None
 1.07A 1e7cA-3lulA:
undetectable		 1e7cA-3lulA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		4 LEU A 171
ASP A  77
LEU A  73
LEU A  76
 None
MN3  A1001 (-2.2A)
None
None
 1.07A 1e7cA-3mjoA:
undetectable		 1e7cA-3mjoA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS
RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
no annotation 		4 LEU G 506
PHE A1218
LEU G 513
LEU G 510
 None
 1.04A 1e7cA-3mmpG:
1.6		 1e7cA-3mmpG:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 LEU A 240
HIS A 243
LEU A  80
LEU A  78
 None
 1.08A 1e7cA-3nksA:
undetectable		 1e7cA-3nksA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 LEU A 169
HIS A 166
LEU A 137
LEU A 140
 None
 1.07A 1e7cA-3pwzA:
undetectable		 1e7cA-3pwzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		4 TYR A 128
LEU A  34
PHE A  38
LEU A  27
 None
 1.06A 1e7cA-3q1oA:
2.4		 1e7cA-3q1oA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN

(Danio rerio;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU A  73
PHE A  75
LEU A 101
LEU A  98
 None
 0.94A 1e7cA-3v44A:
undetectable		 1e7cA-3v44A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0s HYGROMYCIN-B
4-O-KINASE

(Escherichia
coli) 		PF01636
(APH) 		4 LEU A 267
PHE A 234
LEU A 274
LEU A 271
 None
 0.87A 1e7cA-3w0sA:
undetectable		 1e7cA-3w0sA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 LEU A 270
HIS A 267
ASP A 313
LEU A 309
 None
 1.05A 1e7cA-3x0yA:
3.4		 1e7cA-3x0yA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3t DNA MISMATCH REPAIR
PROTEIN HSM3

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 138
ASN A 133
LEU A 101
LEU A 105
 None
 1.04A 1e7cA-4a3tA:
undetectable		 1e7cA-4a3tA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0r PUTATIVE AMINO ACID
BINDING PROTEIN

(Streptococcus
mutans) 		PF00497
(SBP_bac_3) 		4 LEU A 211
ASN A 217
LEU A 223
LEU A 220
 None
 0.98A 1e7cA-4c0rA:
undetectable		 1e7cA-4c0rA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 LEU A 474
ASP A 454
LEU A 455
LEU A 453
 None
 0.83A 1e7cA-4c2xA:
undetectable		 1e7cA-4c2xA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwn BCL10-INTERACTING
CARD PROTEIN

(Homo sapiens) 		no annotation 4 LEU A  62
PHE A  51
LEU A  69
LEU A  66
 CSO  A  63 ( 3.8A)
None
None
CSO  A  63 ( 4.4A)
 1.08A 1e7cA-4dwnA:
undetectable		 1e7cA-4dwnA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

([Candida]
glabrata) 		PF16796
(Microtub_bd) 		4 LEU A 425
ASP A 438
LEU A 439
LEU A 440
 None
 1.05A 1e7cA-4gkpA:
undetectable		 1e7cA-4gkpA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h18 CMT1

(Corynebacterium
glutamicum) 		PF00756
(Esterase) 		4 TYR A 206
LEU A 173
LEU A 165
LEU A 169
 None
 0.65A 1e7cA-4h18A:
undetectable		 1e7cA-4h18A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 LEU M  31
ASN M  36
LEU M   4
LEU M   8
 None
 0.95A 1e7cA-4heaM:
1.6		 1e7cA-4heaM:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i16 CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11

(Mus musculus) 		PF00619
(CARD) 		4 LEU A  33
ASN A  71
LEU A  76
LEU A  77
 None
 0.94A 1e7cA-4i16A:
undetectable		 1e7cA-4i16A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmf EXOENZYME T
PROBABLE CHAPERONE

(Pseudomonas
aeruginosa) 		PF05932
(CesT)
no annotation 		4 LEU B 105
HIS B 102
LEU A  53
LEU A  54
 None
 0.67A 1e7cA-4jmfB:
undetectable		 1e7cA-4jmfB:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jup CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11

(Homo sapiens) 		PF00619
(CARD) 		4 LEU A  33
ASN A  71
LEU A  76
LEU A  77
 None
 0.97A 1e7cA-4jupA:
undetectable		 1e7cA-4jupA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcm TRANSESTERASE

(Aspergillus
terreus) 		PF00144
(Beta-lactamase) 		4 LEU A 198
ASP A 107
LEU A 108
LEU A 105
 None
 0.92A 1e7cA-4lcmA:
undetectable		 1e7cA-4lcmA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgm VPS4 AAA ATPASE

(Sulfolobus
solfataricus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 LEU A 207
ASP A 257
LEU A 261
LEU A 256
 None
 1.08A 1e7cA-4lgmA:
undetectable		 1e7cA-4lgmA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 TYR A 328
ASP A 148
LEU A 150
LEU A 147
 CL  A 406 ( 4.6A)
None
None
None
 0.98A 1e7cA-4onoA:
undetectable		 1e7cA-4onoA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN

(Vibrio cholerae) 		no annotation 4 TYR E 255
LEU E 192
ASP E 185
LEU E 188
 None
 1.04A 1e7cA-4p9uE:
2.1		 1e7cA-4p9uE:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 HIS A 268
ASP A 232
LEU A 231
LEU A 235
 None
 0.97A 1e7cA-4pzvA:
undetectable		 1e7cA-4pzvA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd9 AMYLOID-LIKE PROTEIN
1

(Homo sapiens) 		PF12925
(APP_E2) 		4 LEU A 477
ASP A 468
LEU A 464
LEU A 467
 None
 1.02A 1e7cA-4rd9A:
2.8		 1e7cA-4rd9A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Arthrobacter
sp. FB24) 		PF13377
(Peripla_BP_3) 		4 TYR A  84
LEU A 331
ASP A 153
LEU A 152
 LBT  A 401 ( 3.7A)
None
LBT  A 401 (-3.0A)
None
 1.05A 1e7cA-4rkrA:
undetectable		 1e7cA-4rkrA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN

(Chlamydomonas
reinhardtii) 		PF12895
(ANAPC3)
PF13174
(TPR_6) 		4 ASN A 244
ASP A 275
LEU A 279
LEU A 274
 None
 0.82A 1e7cA-4uzyA:
2.2		 1e7cA-4uzyA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)

(Clostridium
acetobutylicum) 		PF07470
(Glyco_hydro_88) 		4 LEU A  83
ASN A  78
ASP A  32
LEU A  31
 None
 1.04A 1e7cA-4wu0A:
undetectable		 1e7cA-4wu0A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 446
PHE A 448
LEU A 473
LEU A 470
 None
 0.84A 1e7cA-4z0cA:
undetectable		 1e7cA-4z0cA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE

(Streptomyces
globisporus) 		PF00668
(Condensation) 		4 LEU A  78
HIS A  85
ASP A  28
LEU A  24
 None
 0.98A 1e7cA-4zxwA:
undetectable		 1e7cA-4zxwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5c LRRTM

(synthetic
construct) 		PF13855
(LRR_8) 		4 LEU A 152
PHE A 154
LEU A 179
LEU A 176
 None
 0.88A 1e7cA-5a5cA:
undetectable		 1e7cA-5a5cA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 TYR A 148
ASP A 214
LEU A 217
LEU A 213
 None
 0.96A 1e7cA-5aa5A:
undetectable		 1e7cA-5aa5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		4 LEU A 141
HIS A 138
LEU A  64
LEU A  63
 None
 1.08A 1e7cA-5b5rA:
2.1		 1e7cA-5b5rA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola) 		PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 LEU A  98
PHE A 100
ASP A  79
LEU A  78
 None
 1.01A 1e7cA-5c92A:
undetectable		 1e7cA-5c92A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN

(Leishmania
donovani) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 TYR A  60
ASN A  31
LEU A  52
LEU A  51
 None
 1.04A 1e7cA-5cfkA:
undetectable		 1e7cA-5cfkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9c HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		4 LEU A 366
PHE A 363
ASP A 403
LEU A 406
 None
 1.09A 1e7cA-5e9cA:
undetectable		 1e7cA-5e9cA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epf PEROXIREDOXIN

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 HIS A  58
PHE A  59
ASP A 150
LEU A 153
 None
 0.81A 1e7cA-5epfA:
undetectable		 1e7cA-5epfA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 4 LEU C  99
HIS C  96
LEU C 348
LEU C  88
 None
HEM  C 502 (-3.9A)
HEM  C 502 ( 4.3A)
HEM  C 502 (-3.7A)
 1.07A 1e7cA-5ex6C:
3.3		 1e7cA-5ex6C:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis) 		PF00067
(p450) 		4 LEU A  96
HIS A  93
LEU A 343
LEU A  85
 None
HEM  A 401 (-3.9A)
HEM  A 401 ( 4.0A)
HEM  A 401 (-3.9A)
 0.97A 1e7cA-5ex8A:
undetectable		 1e7cA-5ex8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5u BETA-HEXOSAMINIDASE

(Pseudomonas
aeruginosa) 		PF00933
(Glyco_hydro_3) 		4 LEU A  30
ASP A 111
LEU A 110
LEU A  59
 None
 1.02A 1e7cA-5g5uA:
undetectable		 1e7cA-5g5uA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1

(Schizosaccharomyces
pombe) 		PF09427
(DUF2014) 		4 TYR A 860
LEU A 790
PHE A 791
LEU A 787
 None
 0.98A 1e7cA-5gpdA:
3.2		 1e7cA-5gpdA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hca CALRETICULIN,CALRETI
CULIN

(Entamoeba
histolytica) 		no annotation 4 HIS C  19
PHE C  18
ASP C 324
LEU C 326
 None
 1.02A 1e7cA-5hcaC:
undetectable		 1e7cA-5hcaC:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh3 OXYA PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		4 LEU A  96
HIS A  93
LEU A 343
LEU A  85
 None
HEM  A 401 (-3.9A)
HEM  A 401 (-4.1A)
HEM  A 401 (-3.9A)
 0.97A 1e7cA-5hh3A:
undetectable		 1e7cA-5hh3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkq CDII IMMUNITY
PROTEIN
CONTACT-DEPENDENT
INHIBITOR A

(Escherichia
coli) 		PF14436
(EndoU_bacteria)
no annotation 		4 TYR A 236
HIS A 204
PHE A 209
ASP I  48
 None
 1.05A 1e7cA-5hkqA:
undetectable		 1e7cA-5hkqA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA

(Listeria
monocytogenes) 		PF01297
(ZnuA) 		4 LEU A 308
HIS A 305
ASP A 194
LEU A 195
 None
 1.05A 1e7cA-5i4kA:
undetectable		 1e7cA-5i4kA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		4 LEU A 247
HIS A 251
LEU A 282
LEU A 279
 None
 0.79A 1e7cA-5jjpA:
undetectable		 1e7cA-5jjpA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 LEU B  72
HIS B 192
PHE B  76
ASP B 367
 None
 1.08A 1e7cA-5kohB:
undetectable		 1e7cA-5kohB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1t MUCR
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		4 LEU A 552
HIS A 550
ASP A 506
LEU A 505
 None
 1.04A 1e7cA-5m1tA:
undetectable		 1e7cA-5m1tA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nws SAACMM

(Streptomyces
antibioticus) 		no annotation 4 LEU A 426
ASP A 168
LEU A 169
LEU A 170
 None
 1.06A 1e7cA-5nwsA:
3.8		 1e7cA-5nwsA:
9.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 4 TYR A  30
LEU A  66
HIS A  67
ASN A  99
 None
 0.79A 1e7cA-5oriA:
39.4		 1e7cA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3t FUSION PROTEIN OF
NUCLEOPROTEIN AND
MINOR NUCLEOPROTEIN
VP30

(Zaire
ebolavirus) 		PF05505
(Ebola_NP)
PF11507
(Transcript_VP30) 		4 TYR A 211
LEU A 235
PHE A 238
LEU A 171
 None
 1.07A 1e7cA-5t3tA:
2.4		 1e7cA-5t3tA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 LEU A  76
HIS A  77
LEU A 165
LEU A 169
 None
TYR  A 401 (-3.5A)
None
None
 0.95A 1e7cA-5thhA:
undetectable		 1e7cA-5thhA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 TYR A  96
PHE A 328
ASP A 233
LEU A 234
 None
 1.06A 1e7cA-5thhA:
undetectable		 1e7cA-5thhA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 LEU C 437
ASN C 434
LEU C1022
LEU C 706
 None
 1.08A 1e7cA-5tw1C:
undetectable		 1e7cA-5tw1C:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E

(Micromonospora
griseorubida) 		PF00067
(p450) 		4 LEU A  94
HIS A  91
LEU A 347
LEU A  83
 None
HEM  A 401 (-3.9A)
HEM  A 401 (-3.2A)
HEM  A 401 (-3.4A)
 0.84A 1e7cA-5uhuA:
undetectable		 1e7cA-5uhuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6p ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE HRD1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 125
HIS A 122
ASP A 161
LEU A 157
 None
 1.04A 1e7cA-5v6pA:
1.7		 1e7cA-5v6pA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbn DNA POLYMERASE
EPSILON SUBUNIT 2

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF12213
(Dpoe2NT) 		4 LEU A 451
HIS A 450
ASP A 466
LEU A 469
 None
 1.06A 1e7cA-5vbnA:
undetectable		 1e7cA-5vbnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7k OXAG

(Penicillium
oxalicum) 		no annotation 4 LEU A  64
ASN A 102
LEU A  48
LEU A  50
 None
 1.08A 1e7cA-5w7kA:
undetectable		 1e7cA-5w7kA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		4 LEU A 200
HIS A 197
LEU A 177
LEU A 181
 None
 0.90A 1e7cA-5wayA:
undetectable		 1e7cA-5wayA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		4 LEU A 225
HIS A 228
ASP A  94
LEU A  92
 None
 0.93A 1e7cA-5wwtA:
undetectable		 1e7cA-5wwtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 4 LEU 4 685
PHE 4 683
LEU 4 607
LEU 4 634
 None
 0.84A 1e7cA-5zvs4:
undetectable		 1e7cA-5zvs4:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 4 HIS A1217
PHE A1214
ASP A1196
LEU A1195
 None
 0.65A 1e7cA-6apxA:
2.6		 1e7cA-6apxA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 4 LEU A 292
ASP A 326
LEU A 325
LEU A 329
 None
 1.02A 1e7cA-6bfiA:
2.1		 1e7cA-6bfiA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckg D-GLYCERATE 3-KINASE

(Cryptococcus
neoformans) 		no annotation 4 LEU A 212
HIS A 213
LEU A 173
LEU A 178
 None
 0.82A 1e7cA-6ckgA:
undetectable		 1e7cA-6ckgA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Homo sapiens) 		no annotation 4 TYR A 161
LEU A 241
HIS A 201
LEU A 195
 None
 0.98A 1e7cA-6d7tA:
undetectable		 1e7cA-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejj WLAC PROTEIN

(Campylobacter
jejuni) 		no annotation 4 LEU A 317
ASN A 322
ASP A 209
LEU A 208
 None
 0.93A 1e7cA-6ejjA:
undetectable		 1e7cA-6ejjA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekv TOXIN COMPLEX
COMPONENT ORF-X2

(Clostridium
botulinum) 		no annotation 4 LEU A 736
ASN A 485
ASP A 169
LEU A 170
 None
 0.96A 1e7cA-6ekvA:
2.9		 1e7cA-6ekvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f36 MITOCHONDRIAL ATP
SYNTHASE SUBUNIT 6
MITOCHONDRIAL ATP
SYNTHASE SUBUNIT
ASA6

(Polytomella sp.
Pringsheim
198.80) 		no annotation 4 LEU M 251
HIS M 252
ASP N 102
LEU N 105
 None
 1.05A 1e7cA-6f36M:
3.1		 1e7cA-6f36M:
9.07