SIMILAR PATTERNS OF AMINO ACIDS FOR 1E7C_A_HLTA4004_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		4 VAL A 128
PHE A 130
SER A 105
VAL A 103
 None
 0.93A 1e7cA-1dl5A:
0.0		 1e7cA-1dl5A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		4 VAL A 282
PHE A 222
SER A 277
VAL A 278
 None
 1.18A 1e7cA-1gynA:
0.0		 1e7cA-1gynA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j4a D-LACTATE
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 149
PHE A 161
SER A 204
VAL A 202
 None
 1.36A 1e7cA-1j4aA:
undetectable		 1e7cA-1j4aA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvg GUANYLATE KINASE

(Mus musculus) 		PF00625
(Guanylate_kin) 		4 VAL A   8
PHE A 165
SER A  10
VAL A 102
 None
None
None
5GP  A1202 (-3.7A)
 1.46A 1e7cA-1lvgA:
undetectable		 1e7cA-1lvgA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 VAL A 280
PHE A 335
SER A 768
VAL A 769
 None
 1.43A 1e7cA-1rrhA:
2.7		 1e7cA-1rrhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND

(Mycobacterium
tuberculosis) 		PF01436
(NHL) 		4 VAL A  49
PHE A  22
SER A  41
VAL A  39
 None
 1.43A 1e7cA-1rwlA:
undetectable		 1e7cA-1rwlA:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 VAL A 216
PHE A 228
SER A 232
VAL A 235
 None
DKA  A1001 (-4.4A)
DKA  A1001 (-3.5A)
DKA  A1001 ( 4.9A)
 0.49A 1e7cA-1tf0A:
36.9		 1e7cA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		4 VAL A 238
PHE A 230
SER A 242
VAL A 240
 None
 1.38A 1e7cA-2amlA:
1.3		 1e7cA-2amlA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dld D-LACTATE
DEHYDROGENASE

(Lactobacillus
helveticus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 149
PHE A 161
SER A 204
VAL A 202
 None
 1.33A 1e7cA-2dldA:
undetectable		 1e7cA-2dldA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igw PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Caenorhabditis
elegans) 		PF00160
(Pro_isomerase) 		4 VAL A 104
PHE A 120
SER A 106
VAL A 135
 None
PRO  A 202 (-3.6A)
None
None
 1.33A 1e7cA-2igwA:
undetectable		 1e7cA-2igwA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 VAL B 480
PHE B 466
SER B 470
VAL B 474
 None
 1.37A 1e7cA-2o8eB:
0.0		 1e7cA-2o8eB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q78 UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		no annotation 4 VAL A  45
PHE A 114
SER A  49
VAL A  48
 None
 1.48A 1e7cA-2q78A:
undetectable		 1e7cA-2q78A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 465
PHE A 343
SER A 369
VAL A 370
 None
None
CA  A3716 ( 4.7A)
None
 1.35A 1e7cA-2qt6A:
undetectable		 1e7cA-2qt6A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 VAL A 177
PHE A 523
SER A  78
VAL A  79
 None
 1.46A 1e7cA-3h09A:
undetectable		 1e7cA-3h09A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpd HYDROXYETHYLTHIAZOLE
KINASE

(Pyrococcus
horikoshii) 		PF02110
(HK) 		4 VAL A 260
PHE A   3
SER A 216
VAL A 219
 None
 1.41A 1e7cA-3hpdA:
1.9		 1e7cA-3hpdA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		4 VAL A 121
PHE A 156
SER A 158
VAL A 143
 None
 1.30A 1e7cA-3mkqA:
undetectable		 1e7cA-3mkqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC

(Bacillus
anthracis) 		PF00425
(Chorismate_bind) 		4 VAL A 305
PHE A 328
SER A 146
VAL A 144
 None
 1.36A 1e7cA-3os6A:
undetectable		 1e7cA-3os6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps0 CRISPR-ASSOCIATED
PROTEIN, CSA2

(Sulfolobus
solfataricus) 		PF01905
(DevR) 		4 VAL A  62
PHE A  81
SER A  76
VAL A  72
 None
 1.45A 1e7cA-3ps0A:
undetectable		 1e7cA-3ps0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 466
PHE A 344
SER A 370
VAL A 371
 None
 1.34A 1e7cA-3pxlA:
undetectable		 1e7cA-3pxlA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfe PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE FAMILY
PROTEIN

(Coccidioides
immitis) 		PF00701
(DHDPS) 		4 VAL A 139
PHE A 195
SER A 193
VAL A 168
 None
 1.09A 1e7cA-3qfeA:
undetectable		 1e7cA-3qfeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rju BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Yersinia pestis) 		PF00144
(Beta-lactamase) 		4 VAL A 322
PHE A 332
SER A 336
VAL A 339
 None
 1.13A 1e7cA-3rjuA:
undetectable		 1e7cA-3rjuA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqg 2-METHYLCITRATE
SYNTHASE

(Coxiella
burnetii) 		PF00285
(Citrate_synt) 		4 VAL A 123
PHE A  44
SER A 332
VAL A 334
 None
 1.34A 1e7cA-3tqgA:
undetectable		 1e7cA-3tqgA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uvf INTRON-ENCODED DNA
ENDONUCLEASE I-HJEMI

(Trichoderma
reesei) 		PF00961
(LAGLIDADG_1) 		4 VAL A 214
PHE A 189
SER A 210
VAL A 211
 None
 1.43A 1e7cA-3uvfA:
undetectable		 1e7cA-3uvfA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli) 		PF00350
(Dynamin_N) 		4 VAL A 321
PHE A 381
SER A 385
VAL A 388
 None
 1.34A 1e7cA-4aurA:
1.6		 1e7cA-4aurA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5a PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
F, MITOCHONDRIAL

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 VAL X 139
PHE X 155
SER X 141
VAL X 170
 None
67Z  X 301 (-3.8A)
None
None
 1.34A 1e7cA-4j5aX:
undetectable		 1e7cA-4j5aX:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9a TAT PATHWAY SIGNAL
SEQUENCE DOMAIN
PROTEIN

(Parabacteroides
merdae) 		PF13472
(Lipase_GDSL_2) 		4 VAL A 125
PHE A  51
SER A 127
VAL A 171
 None
 1.46A 1e7cA-4q9aA:
undetectable		 1e7cA-4q9aA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		4 VAL A 217
PHE A 238
SER A 231
VAL A 229
 None
 1.27A 1e7cA-5cqfA:
undetectable		 1e7cA-5cqfA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 VAL A 215
PHE A 227
SER A 231
VAL A 234
 None
 0.41A 1e7cA-5dqfA:
40.7		 1e7cA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		4 VAL A 216
PHE A 228
SER A 232
VAL A 235
 None
 0.48A 1e7cA-5ghkA:
37.5		 1e7cA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh1 ALDOSE REDUCTASE,
AKR4C7

(Zea mays) 		PF00248
(Aldo_ket_red) 		4 VAL A 249
PHE A   5
SER A  15
VAL A  16
 None
 1.14A 1e7cA-5jh1A:
undetectable		 1e7cA-5jh1A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 466
PHE A 348
SER A 374
VAL A 375
 None
 1.19A 1e7cA-5mewA:
undetectable		 1e7cA-5mewA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjt MAJOR CAPSID PROTEIN

(Escherichia
virus T5) 		PF05065
(Phage_capsid) 		4 VAL A 345
PHE A 393
SER A 390
VAL A 388
 None
 1.45A 1e7cA-5tjtA:
undetectable		 1e7cA-5tjtA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 4 VAL A 201
PHE A 167
SER A 189
VAL A 191
 None
 1.44A 1e7cA-5w19A:
undetectable		 1e7cA-5w19A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 4 VAL A 216
PHE A 228
SER A 232
VAL A 235
 None
 0.54A 1e7cA-5yxeA:
36.9		 1e7cA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT

(Pyrococcus
furiosus) 		no annotation 4 VAL M 273
PHE M 239
SER M 243
VAL M 246
 None
 1.11A 1e7cA-6cfwM:
2.3		 1e7cA-6cfwM:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 4 VAL A 314
PHE A 318
SER A 429
VAL A 428
 None
 1.49A 1e7cA-6ei3A:
0.5		 1e7cA-6ei3A:
20.88