SIMILAR PATTERNS OF AMINO ACIDS FOR 1E7C_A_HLTA4002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 ARG A  55
ALA A  56
ALA A 274
GLU A 277
 None
 1.21A 1e7cA-1bjwA:
0.1		 1e7cA-1bjwA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c04 RIBOSOMAL PROTEIN
L11

(Haloarcula
marismortui) 		PF00298
(Ribosomal_L11) 		4 ARG C  41
ALA C  44
ALA C  58
GLU C  57
 None
None
A  E  30 ( 3.5A)
None
 1.11A 1e7cA-1c04C:
undetectable		 1e7cA-1c04C:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		4 ARG A 296
ALA A 319
LYS A 318
GLU A 299
 None
 1.07A 1e7cA-1fp9A:
0.0		 1e7cA-1fp9A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 ARG A  13
ALA A 227
ALA A 331
GLU A 329
 None
 1.23A 1e7cA-1guqA:
undetectable		 1e7cA-1guqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		4 ALA A 105
ALA A  61
LYS A  60
GLU A  55
 None
 0.99A 1e7cA-1h14A:
0.0		 1e7cA-1h14A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9x M32 CARBOXYPEPTIDASE

(Pyrococcus
furiosus) 		PF02074
(Peptidase_M32) 		4 ALA A 413
ALA A 118
LYS A 117
GLU A 120
 None
 1.09A 1e7cA-1k9xA:
2.9		 1e7cA-1k9xA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		4 ARG A 183
ALA A 182
ALA A 219
GLU A 221
 None
 1.19A 1e7cA-1ktnA:
undetectable		 1e7cA-1ktnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no7 MAJOR CAPSID PROTEIN

(Human
alphaherpesvirus
1) 		PF03122
(Herpes_MCP) 		4 ARG A 660
ALA A 613
ALA A 688
GLU A 685
 None
 1.15A 1e7cA-1no7A:
0.0		 1e7cA-1no7A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on0 YYCN PROTEIN

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		4 ALA A 131
ALA A  31
LYS A  30
GLU A  27
 None
 1.12A 1e7cA-1on0A:
undetectable		 1e7cA-1on0A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 316
ALA A 340
LYS A 341
GLU A 344
 None
 0.82A 1e7cA-1r2jA:
0.0		 1e7cA-1r2jA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ALA A 110
ALA A 119
LYS A 118
GLU A 117
 None
 1.13A 1e7cA-1sb3A:
undetectable		 1e7cA-1sb3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		4 ARG A 100
ALA A  58
ALA A 126
GLU A 128
 None
 0.99A 1e7cA-1t9kA:
undetectable		 1e7cA-1t9kA:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 ARG A 209
ALA A 213
ALA A 350
GLU A 354
 DKA  A1001 ( 4.6A)
DKA  A1001 ( 4.0A)
DKA  A1002 ( 3.8A)
DKA  A1002 ( 4.4A)
 0.19A 1e7cA-1tf0A:
36.9		 1e7cA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 ARG A 209
ALA A 350
LYS A 351
GLU A 354
 DKA  A1001 ( 4.6A)
DKA  A1002 ( 3.8A)
DKA  A1002 (-2.6A)
DKA  A1002 ( 4.4A)
 0.97A 1e7cA-1tf0A:
36.9		 1e7cA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 ARG A 289
ALA A 312
LYS A 311
GLU A 292
 None
 1.05A 1e7cA-1tz7A:
undetectable		 1e7cA-1tz7A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5v CITE

(Mycobacterium
tuberculosis) 		PF03328
(HpcH_HpaI) 		4 ARG A 149
ALA A 136
ALA A 180
GLU A 194
 None
 1.06A 1e7cA-1u5vA:
undetectable		 1e7cA-1u5vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 ARG A 176
ALA A 177
ALA A 139
GLU A 140
 None
 1.10A 1e7cA-1ub3A:
undetectable		 1e7cA-1ub3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 ARG A 176
ALA A 177
ALA A 142
GLU A 140
 None
 1.12A 1e7cA-1ub3A:
undetectable		 1e7cA-1ub3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ARG A 247
ALA A 164
ALA A 257
GLU A 253
 None
 1.08A 1e7cA-1vc2A:
undetectable		 1e7cA-1vc2A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ARG A 186
ALA A 189
ALA A 213
GLU A 215
 None
KCX  A 188 ( 3.7A)
None
None
 1.15A 1e7cA-1w78A:
undetectable		 1e7cA-1w78A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 ARG A 151
ALA A 150
ALA A   7
GLU A   5
 None
 0.67A 1e7cA-1yirA:
undetectable		 1e7cA-1yirA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9e PERIDININ-CHLOROPHYL
L A PROTEIN

(Amphidinium
carterae) 		PF02429
(PCP) 		4 ARG A  99
ALA A 102
ALA A 148
LYS A   1
 None
 1.17A 1e7cA-2c9eA:
1.6		 1e7cA-2c9eA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx7 STEROL CARRIER
PROTEIN 2

(Thermus
thermophilus) 		PF02036
(SCP2) 		4 ARG A  38
ALA A  36
LYS A 105
GLU A 103
 None
 1.15A 1e7cA-2cx7A:
undetectable		 1e7cA-2cx7A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 ALA A  65
ALA A  33
LYS A  32
GLU A  71
 None
 1.17A 1e7cA-2dkdA:
2.3		 1e7cA-2dkdA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		4 ARG A 529
ALA A 517
ALA A 440
GLU A 441
 None
 1.17A 1e7cA-2eaeA:
2.2		 1e7cA-2eaeA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehw HYPOTHETICAL PROTEIN
TTHB059

(Thermus
thermophilus) 		PF11483
(DUF3209) 		4 ARG A  38
ALA A   8
LYS A   3
GLU A   5
 None
 0.91A 1e7cA-2ehwA:
3.4		 1e7cA-2ehwA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ARG A  57
ALA A  58
ALA A  18
GLU A  15
 None
 1.14A 1e7cA-2elcA:
undetectable		 1e7cA-2elcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		4 ALA A   8
ALA A  82
LYS A  78
GLU A 181
 TTP  A 500 (-3.5A)
None
None
TTP  A 500 (-3.0A)
 1.21A 1e7cA-2ggqA:
undetectable		 1e7cA-2ggqA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hbo HYPOTHETICAL PROTEIN
(NP_422103.1)

(Caulobacter
vibrioides) 		PF03061
(4HBT) 		4 ARG A 144
ALA A 143
ALA A 152
GLU A 150
 None
 1.12A 1e7cA-2hboA:
undetectable		 1e7cA-2hboA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6e HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02621
(VitK2_biosynth) 		4 ARG A 106
ALA A 146
ALA A 136
GLU A 134
 None
 1.21A 1e7cA-2i6eA:
undetectable		 1e7cA-2i6eA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jvf DE NOVO PROTEIN M7

(unidentified) 		no annotation 4 ARG A  67
ALA A  66
LYS A  59
GLU A  60
 None
 1.02A 1e7cA-2jvfA:
undetectable		 1e7cA-2jvfA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8a POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF00645
(zf-PARP) 		4 ALA A  19
ALA A  14
LYS A  15
GLU A  12
 None
 1.02A 1e7cA-2n8aA:
undetectable		 1e7cA-2n8aA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8i DESIGNED PROTEIN
DA05

(synthetic
construct) 		no annotation 4 ALA A  30
ALA A  18
LYS A  16
GLU A  19
 None
 1.17A 1e7cA-2n8iA:
3.0		 1e7cA-2n8iA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqo GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		4 ARG A 175
ALA A  78
ALA A 183
GLU A 182
 None
 1.07A 1e7cA-2nqoA:
undetectable		 1e7cA-2nqoA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		4 ARG A 216
ALA A 257
LYS A 261
GLU A 260
 None
 1.14A 1e7cA-2pd3A:
undetectable		 1e7cA-2pd3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rno PUTATIVE DNA-BINDING
PROTEIN

(Oryza sativa) 		PF02037
(SAP) 		4 ALA A  88
ALA A  69
LYS A  65
GLU A  66
 None
 1.16A 1e7cA-2rnoA:
2.2		 1e7cA-2rnoA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 ARG A 456
ALA A 480
ALA A 353
GLU A 355
 None
 1.13A 1e7cA-2zpaA:
undetectable		 1e7cA-2zpaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjb PROBABLE
TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 ARG A  49
ALA A  33
LYS A  36
GLU A  35
 None
 1.07A 1e7cA-3bjbA:
3.2		 1e7cA-3bjbA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		4 ARG A 408
ALA A 407
LYS A 411
GLU A 452
 None
 1.19A 1e7cA-3c7oA:
undetectable		 1e7cA-3c7oA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		4 ARG A 213
ALA A 240
LYS A 239
GLU A 234
 None
 1.17A 1e7cA-3cnnA:
undetectable		 1e7cA-3cnnA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2

(Burkholderia
pseudomallei) 		PF00464
(SHMT) 		4 ARG A 409
ALA A 405
ALA A 395
GLU A 391
 None
 1.22A 1e7cA-3ecdA:
2.9		 1e7cA-3ecdA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		4 ALA A 373
ALA A 253
LYS A 254
GLU A 258
 None
 1.21A 1e7cA-3gzsA:
undetectable		 1e7cA-3gzsA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h90 FERROUS-IRON EFFLUX
PUMP FIEF

(Escherichia
coli) 		PF01545
(Cation_efflux)
PF16916
(ZT_dimer) 		4 ARG A 148
ALA A 149
ALA A 201
GLU A 200
 None
 1.11A 1e7cA-3h90A:
2.4		 1e7cA-3h90A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 ARG A  87
ALA A  86
ALA A 114
GLU A 116
 None
 1.19A 1e7cA-3i09A:
undetectable		 1e7cA-3i09A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig0 DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 ARG A 631
ALA A 564
LYS A 526
GLU A 454
 ARG  A 631 ( 0.6A)
ALA  A 564 ( 0.0A)
LYS  A 526 ( 0.0A)
GLU  A 454 ( 0.6A)
 1.09A 1e7cA-3ig0A:
undetectable		 1e7cA-3ig0A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 ARG B 946
ALA B 769
ALA B 823
GLU B 786
 None
 1.01A 1e7cA-3o8oB:
undetectable		 1e7cA-3o8oB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9x PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Bacillus
halodurans) 		PF00551
(Formyl_trans_N) 		4 ARG A 176
ALA A 180
ALA A 151
GLU A 153
 SO4  A 214 (-4.4A)
None
None
None
 0.99A 1e7cA-3p9xA:
undetectable		 1e7cA-3p9xA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pef 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING

(Geobacter
metallireducens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ARG A 250
ALA A 100
ALA A 168
LYS A 166
 None
 1.19A 1e7cA-3pefA:
undetectable		 1e7cA-3pefA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 ARG A 249
ALA A 194
ALA A 154
GLU A 157
 None
 0.96A 1e7cA-3ppiA:
undetectable		 1e7cA-3ppiA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7w EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
nitratireducens) 		PF02335
(Cytochrom_C552) 		4 ARG A 469
ALA A 468
ALA A 455
LYS A 456
 None
 1.19A 1e7cA-3s7wA:
undetectable		 1e7cA-3s7wA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ARG A 413
ALA A 414
ALA A 344
GLU A 348
 None
 1.11A 1e7cA-3ue3A:
undetectable		 1e7cA-3ue3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 ALA A 114
ALA A 574
LYS A 575
GLU A 578
 None
 0.79A 1e7cA-3vueA:
undetectable		 1e7cA-3vueA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1o ROQUIN-1

(Homo sapiens) 		no annotation 4 ARG A 251
ALA A 189
ALA A 294
GLU A 293
 None
 1.23A 1e7cA-3x1oA:
undetectable		 1e7cA-3x1oA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE

(Trypanosoma
cruzi) 		PF00102
(Y_phosphatase) 		4 ARG A 232
ALA A 130
LYS A 129
GLU A 124
 FMT  A1302 (-3.8A)
None
FMT  A1304 (-3.2A)
None
 0.88A 1e7cA-4az1A:
undetectable		 1e7cA-4az1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqy POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF00645
(zf-PARP) 		4 ALA A  19
ALA A  14
LYS A  15
GLU A  12
 None
 1.00A 1e7cA-4dqyA:
undetectable		 1e7cA-4dqyA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 ARG A 329
ALA A  61
ALA A 144
GLU A 143
 None
 1.19A 1e7cA-4dvjA:
undetectable		 1e7cA-4dvjA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 ARG A 344
ALA A 345
ALA A 330
GLU A 295
 None
 0.90A 1e7cA-4dykA:
undetectable		 1e7cA-4dykA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1t INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 2

(Homo sapiens) 		PF13181
(TPR_8) 		4 ALA A 253
ALA A 266
LYS A 265
GLU A 262
 None
 1.08A 1e7cA-4g1tA:
2.3		 1e7cA-4g1tA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		4 ARG A 153
ALA A 154
ALA A 258
GLU A 263
 None
 1.08A 1e7cA-4glfA:
undetectable		 1e7cA-4glfA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgv FUMARATE HYDRATASE
CLASS II

(Sinorhizobium
meliloti) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ARG A  67
ALA A  66
ALA A  87
LYS A  85
 None
 1.11A 1e7cA-4hgvA:
undetectable		 1e7cA-4hgvA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		4 ARG A 601
ALA A 538
LYS A 500
GLU A 428
 None
 1.04A 1e7cA-4i3hA:
2.5		 1e7cA-4i3hA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iit PHENYLACETATE-COA
OXYGENASE SUBUNIT
PAAB
PHENYLACETATE-COA
OXYGENASE SUBUNIT
PAAC

(Klebsiella
pneumoniae) 		PF05138
(PaaA_PaaC)
PF06243
(PaaB) 		4 ARG C 146
ALA B  30
ALA B  35
GLU B  37
 None
 0.96A 1e7cA-4iitC:
undetectable		 1e7cA-4iitC:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4juo DNA TOPOISOMERASE 4
SUBUNIT B

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		4 ARG C 601
ALA C 538
LYS C 500
GLU C 428
 None
 1.14A 1e7cA-4juoC:
undetectable		 1e7cA-4juoC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 336
ALA A 361
LYS A 362
GLU A 365
 None
 0.86A 1e7cA-4ktoA:
1.8		 1e7cA-4ktoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ARG A 244
ALA A 305
ALA A 379
GLU A 381
 None
 1.00A 1e7cA-4lbwA:
undetectable		 1e7cA-4lbwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE

(Staphylococcus
aureus) 		PF02423
(OCD_Mu_crystall) 		4 ARG A  10
ALA A 115
ALA A  95
GLU A  93
 None
 1.09A 1e7cA-4mp3A:
undetectable		 1e7cA-4mp3A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Archaeoglobus
fulgidus) 		PF00215
(OMPdecase) 		4 ARG A  92
ALA A  91
ALA A 120
GLU A 122
 None
 1.15A 1e7cA-4muzA:
undetectable		 1e7cA-4muzA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3

(Brucella
melitensis) 		PF13458
(Peripla_BP_6) 		4 ALA A  31
ALA A  48
LYS A  46
GLU A  49
 None
 1.24A 1e7cA-4n0qA:
undetectable		 1e7cA-4n0qA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B

(Streptococcus
thermophilus) 		PF02421
(FeoB_N) 		4 ARG A 197
ALA A 200
ALA A 179
GLU A 177
 ARG  A 197 ( 0.6A)
ALA  A 200 ( 0.0A)
ALA  A 179 ( 0.0A)
GLU  A 177 ( 0.6A)
 0.95A 1e7cA-4nonA:
undetectable		 1e7cA-4nonA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ALA A  33
ALA A 524
LYS A 525
GLU A 529
 None
 1.02A 1e7cA-4pdxA:
undetectable		 1e7cA-4pdxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 ARG B 601
ALA B 540
LYS B 502
GLU B 430
 None
 1.00A 1e7cA-4plbB:
undetectable		 1e7cA-4plbB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A 853
ALA A1041
ALA A1012
GLU A1010
 None
 1.17A 1e7cA-4rcnA:
undetectable		 1e7cA-4rcnA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsx TYPE III EFFECTOR
HOPA1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 ARG A 359
ALA A 137
LYS A 138
GLU A 141
 None
 1.12A 1e7cA-4rsxA:
2.1		 1e7cA-4rsxA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 ARG L 160
ALA L 154
ALA L 210
GLU L 214
 None
 0.99A 1e7cA-4u9iL:
2.2		 1e7cA-4u9iL:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 ARG A 109
ALA A 105
ALA A 141
GLU A 145
 None
 1.00A 1e7cA-4v1yA:
undetectable		 1e7cA-4v1yA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 ARG A 206
ALA A 234
ALA A 260
GLU A 259
 None
 1.06A 1e7cA-4yv7A:
undetectable		 1e7cA-4yv7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomyces
pombe) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		4 ARG I 215
ALA I 266
LYS I 267
GLU I 161
 None
 1.15A 1e7cA-5b04I:
undetectable		 1e7cA-5b04I:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdo DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B

(Staphylococcus
aureus) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 ARG B 601
ALA B 540
LYS B 502
GLU B 430
 None
 1.09A 1e7cA-5cdoB:
undetectable		 1e7cA-5cdoB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 ARG A 217
ALA A 155
LYS A 154
GLU A 151
 None
 0.99A 1e7cA-5e8kA:
3.2		 1e7cA-5e8kA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 ARG A 219
ALA A 156
LYS A 155
GLU A 152
 None
 1.16A 1e7cA-5e8lA:
1.8		 1e7cA-5e8lA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		4 ALA A 100
ALA A 121
LYS A 120
GLU A 119
 None
FRU  A 501 (-3.3A)
None
None
 0.82A 1e7cA-5gooA:
undetectable		 1e7cA-5gooA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4

(Human
alphaherpesvirus
1) 		PF03584
(Herpes_ICP4_N) 		4 ARG A 336
ALA A 406
ALA A 345
GLU A 365
 None
 1.17A 1e7cA-5mhjA:
undetectable		 1e7cA-5mhjA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhk RS1

(Human
alphaherpesvirus
1) 		PF03584
(Herpes_ICP4_N) 		4 ARG A 336
ALA A 406
ALA A 345
GLU A 365
 None
 1.19A 1e7cA-5mhkA:
undetectable		 1e7cA-5mhkA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN

(Chaetomium
thermophilum) 		PF12569
(NARP1)
PF13432
(TPR_16) 		4 ALA A 447
ALA A 460
LYS A 459
GLU A 456
 None
 0.98A 1e7cA-5nnpA:
undetectable		 1e7cA-5nnpA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o30 PUTATIVE
OXIDOREDUCTASE

(Ilumatobacter
coccineus) 		PF13561
(adh_short_C2) 		4 ARG A  25
ALA A  24
ALA A  15
GLU A  50
 None
 1.14A 1e7cA-5o30A:
undetectable		 1e7cA-5o30A:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 4 ARG A 208
ALA A 212
ALA A 349
GLU A 353
 None
 0.23A 1e7cA-5oriA:
39.4		 1e7cA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		4 ARG A 288
ALA A 287
ALA A 331
GLU A 333
 None
 1.21A 1e7cA-5upyA:
undetectable		 1e7cA-5upyA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ARG A 102
ALA A 103
ALA A 290
GLU A 289
 None
 1.05A 1e7cA-5w4xA:
undetectable		 1e7cA-5w4xA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w75 ELONGATION FACTOR TU

(Thermotoga
neapolitana) 		no annotation 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 1.08A 1e7cA-5w75A:
undetectable		 1e7cA-5w75A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 1.06A 1e7cA-5w76A:
undetectable		 1e7cA-5w76A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 0.97A 1e7cA-5w7qA:
undetectable		 1e7cA-5w7qA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 4 ARG A 265
ALA A 264
ALA A  18
GLU A  15
 None
 0.98A 1e7cA-5wabA:
undetectable		 1e7cA-5wabA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk0 DAMAGE-INDUCIBLE
PROTEIN DINB

(Staphylococcus
sp. HMSC055H04) 		no annotation 4 ARG A 102
ALA A 103
ALA A  55
GLU A  53
 None
 1.23A 1e7cA-5wk0A:
undetectable		 1e7cA-5wk0A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 4 ARG A 138
ALA A 134
ALA A 168
GLU A 172
 None
 1.23A 1e7cA-5wt4A:
undetectable		 1e7cA-5wt4A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ALA A1071
ALA A 845
LYS A 844
GLU A 847
 None
 1.08A 1e7cA-5xogA:
3.1		 1e7cA-5xogA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 4 ARG A 209
ALA A 213
ALA A 350
GLU A 354
 None
 0.52A 1e7cA-5yxeA:
36.9		 1e7cA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii) 		no annotation 4 ARG A 199
ALA A 327
LYS A 328
GLU A 331
 None
 1.22A 1e7cA-5z0yA:
undetectable		 1e7cA-5z0yA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 4 ARG A 700
ALA A 699
ALA A 681
GLU A 686
 None
 1.07A 1e7cA-6bfiA:
undetectable		 1e7cA-6bfiA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gqd GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Homo sapiens) 		no annotation 4 ARG A  33
ALA A 247
ALA A 354
GLU A 352
 None
 1.20A 1e7cA-6gqdA:
undetectable		 1e7cA-6gqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9rub RIBULOSE-1,5-BISPHOS
PHATE CARBOXYLASE

(Rhodospirillum
rubrum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 217
ALA A 218
ALA A 182
GLU A 178
 None
 1.08A 1e7cA-9rubA:
undetectable		 1e7cA-9rubA:
21.99