SIMILAR PATTERNS OF AMINO ACIDS FOR 1E7C_A_HLTA4001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvl HULYS11

(Homo sapiens;
Mus musculus) 		PF07686
(V-set) 		4 ARG B  24
ALA B  25
ASP B  70
GLY B  68
 None
 1.19A 1e7cA-1bvlB:
undetectable		 1e7cA-1bvlB:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		4 ARG A 288
ALA A 285
ASP A 265
GLY A 263
 None
 0.92A 1e7cA-1dabA:
undetectable		 1e7cA-1dabA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 ARG A 289
LYS A 291
ASP A 306
GLY A 304
 ARG  A 289 ( 0.6A)
LYS  A 291 ( 0.0A)
ASP  A 306 ( 0.5A)
GLY  A 304 ( 0.0A)
 1.19A 1e7cA-1fxjA:
undetectable		 1e7cA-1fxjA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		4 LYS A 187
ALA A 188
ASP A 126
GLY A 124
 None
None
MAN  A 329 ( 4.9A)
None
 0.91A 1e7cA-1g0vA:
undetectable		 1e7cA-1g0vA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gu3 ENDOGLUCANASE C

(Cellulomonas
fimi) 		PF02018
(CBM_4_9) 		4 ARG A  75
ALA A 126
ASP A  90
GLY A  79
 BGC  A 601 (-3.0A)
BGC  A 602 ( 4.5A)
None
None
 0.96A 1e7cA-1gu3A:
undetectable		 1e7cA-1gu3A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		4 LYS B 203
ALA B 202
ASP B 270
GLY B 275
 None
 1.13A 1e7cA-1gydB:
undetectable		 1e7cA-1gydB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ion PROBABLE CELL
DIVISION INHIBITOR
MIND

(Pyrococcus
horikoshii) 		PF13614
(AAA_31) 		4 LYS A  95
ALA A  96
ASP A  61
GLY A  65
 None
 1.22A 1e7cA-1ionA:
undetectable		 1e7cA-1ionA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ARG A  51
LYS A  65
ALA A  66
GLY A 106
 None
 1.12A 1e7cA-1iyxA:
0.1		 1e7cA-1iyxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 LYS A 203
ALA A 194
ASP A 291
GLY A 293
 None
 1.08A 1e7cA-1kb0A:
0.0		 1e7cA-1kb0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 LYS A  65
ALA A  66
ASP A  14
GLY A 119
 None
 1.15A 1e7cA-1lnzA:
undetectable		 1e7cA-1lnzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ARG B  14
LYS B  17
ALA B  15
ASP B 611
 None
 0.91A 1e7cA-1n60B:
undetectable		 1e7cA-1n60B:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		4 ARG A 262
ALA A 258
ASP A 208
GLY A 228
 SO4  A2711 (-3.1A)
None
SO4  A2711 ( 4.1A)
None
 1.17A 1e7cA-1nhcA:
undetectable		 1e7cA-1nhcA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5j HYPOTHETICAL PROTEIN
MJ1187

(Methanocaldococcus
jannaschii) 		PF03747
(ADP_ribosyl_GH) 		4 LYS A 157
ALA A 159
ASP A 224
GLY A 162
 None
 1.20A 1e7cA-1t5jA:
0.9		 1e7cA-1t5jA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 ARG A 209
LYS A 212
ALA A 213
ASP A 324
GLY A 328
 DKA  A1001 ( 4.6A)
None
DKA  A1001 ( 4.0A)
DKA  A1001 (-4.7A)
DKA  A1001 ( 4.1A)
 0.40A 1e7cA-1tf0A:
36.9		 1e7cA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LYS A 400
ALA A 402
ASP A 433
GLY A 419
 None
 1.20A 1e7cA-1tmoA:
undetectable		 1e7cA-1tmoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Escherichia
coli) 		PF00581
(Rhodanese) 		4 ARG A 178
ALA A 181
ASP A 184
GLY A 193
 None
 1.23A 1e7cA-1urhA:
undetectable		 1e7cA-1urhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		4 ARG A 118
ALA A 117
ASP A 120
GLY A 122
 None
 1.11A 1e7cA-1us4A:
undetectable		 1e7cA-1us4A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ARG A 162
ALA A 165
ASP A 172
GLY A 170
 None
 1.19A 1e7cA-1v5vA:
undetectable		 1e7cA-1v5vA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		4 LYS A 197
ALA A 196
ASP A 355
GLY A 318
 ANP  A 400 (-3.6A)
ANP  A 400 (-3.1A)
ANP  A 400 (-4.2A)
ANP  A 400 ( 3.8A)
 1.06A 1e7cA-1vpeA:
undetectable		 1e7cA-1vpeA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxj TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Thermus
thermophilus) 		PF00290
(Trp_syntA) 		4 ARG A  11
ALA A  10
ASP A 224
GLY A 225
 None
 1.22A 1e7cA-1wxjA:
undetectable		 1e7cA-1wxjA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		4 LYS A 185
ALA A 184
ASP A 179
GLY A  65
 None
 1.12A 1e7cA-1wzcA:
undetectable		 1e7cA-1wzcA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 ARG A 624
ALA A 549
ASP A 622
GLY A 617
 PGR  A 805 (-4.2A)
None
PGR  A 805 (-3.4A)
PGR  A 805 ( 4.9A)
 1.15A 1e7cA-1yiqA:
2.2		 1e7cA-1yiqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aip PROTEIN C ACTIVATOR

(Agkistrodon
contortrix) 		PF00089
(Trypsin) 		4 ARG A  95
ALA A 177
ASP A  96
GLY A 175
 None
 0.97A 1e7cA-2aipA:
undetectable		 1e7cA-2aipA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2

(Homo sapiens) 		PF01583
(APS_kinase) 		4 ARG A 176
LYS A 175
ALA A 177
GLY A 180
 None
 1.17A 1e7cA-2ax4A:
undetectable		 1e7cA-2ax4A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		4 ARG A  18
LYS A  53
ALA A  54
ASP A  12
 None
 0.97A 1e7cA-2cevA:
undetectable		 1e7cA-2cevA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Pyrococcus
horikoshii) 		PF03483
(B3_4)
PF03484
(B5) 		4 ARG A  56
ALA A  31
ASP A  58
GLY A  64
 None
 1.15A 1e7cA-2cxiA:
undetectable		 1e7cA-2cxiA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2evr COG0791: CELL
WALL-ASSOCIATED
HYDROLASES
(INVASION-ASSOCIATED
PROTEINS)

(Nostoc
punctiforme) 		PF00877
(NLPC_P60) 		4 ARG A 196
ALA A 210
ASP A 202
GLY A 208
 None
 1.19A 1e7cA-2evrA:
undetectable		 1e7cA-2evrA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ARG A 372
ALA A 347
ASP A 401
GLY A 344
 None
 1.00A 1e7cA-2f3oA:
undetectable		 1e7cA-2f3oA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		4 ARG A 227
ALA A 300
ASP A 371
GLY A 304
 None
 1.15A 1e7cA-2f5uA:
undetectable		 1e7cA-2f5uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		4 ARG A  89
ALA A  88
ASP A  91
GLY A  65
 None
 1.09A 1e7cA-2ghpA:
undetectable		 1e7cA-2ghpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		4 ARG A  71
LYS A  73
ALA A  74
GLY A 289
 None
 0.99A 1e7cA-2glfA:
undetectable		 1e7cA-2glfA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		4 ARG G 320
ALA G 317
ASP G 297
GLY G 295
 None
 1.01A 1e7cA-2iouG:
undetectable		 1e7cA-2iouG:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 ARG A 252
ALA A 273
ASP A 254
GLY A 275
 None
 0.98A 1e7cA-2j0jA:
undetectable		 1e7cA-2j0jA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyy POSSIBLE
ATP-DEPENDENT DNA
HELICASE
RECG-RELATED PROTEIN

(Nitrosomonas
europaea) 		PF04326
(AlbA_2) 		4 ARG A  24
ALA A  25
ASP A  55
GLY A  70
 None
 1.18A 1e7cA-2kyyA:
undetectable		 1e7cA-2kyyA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lmc DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Escherichia
coli) 		no annotation 4 ARG B  77
ALA B  28
ASP B  52
GLY B  32
 None
 1.14A 1e7cA-2lmcB:
undetectable		 1e7cA-2lmcB:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 ARG A 273
ALA A 276
ASP A 217
GLY A 218
 None
 1.22A 1e7cA-2plaA:
2.3		 1e7cA-2plaA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux0 CALCIUM-CALMODULIN
DEPENDENT PROTEIN
KINASE (CAM KINASE)
II GAMMA

(Homo sapiens) 		PF08332
(CaMKII_AD) 		4 ARG A 506
ALA A 476
ASP A 474
GLY A 472
 None
 1.08A 1e7cA-2ux0A:
undetectable		 1e7cA-2ux0A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE

(Escherichia
coli) 		PF03328
(HpcH_HpaI) 		4 ARG A  12
ALA A  68
ASP A  41
GLY A  39
 None
 1.19A 1e7cA-2vwsA:
undetectable		 1e7cA-2vwsA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ARG A  49
ALA A  19
ASP A  51
GLY A  17
 None
 0.87A 1e7cA-2wtbA:
undetectable		 1e7cA-2wtbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ARG A 367
ALA A 486
ASP A 423
GLY A 419
 K  A2903 (-4.0A)
None
None
None
 1.05A 1e7cA-3actA:
undetectable		 1e7cA-3actA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq2 6B PROTEIN

(Agrobacterium
vitis) 		PF02027
(RolB_RolC) 		4 ARG A  12
ALA A  72
ASP A  10
GLY A  76
 None
 1.07A 1e7cA-3aq2A:
undetectable		 1e7cA-3aq2A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A  63
ALA A   8
ASP A  65
GLY A   6
 None
 0.98A 1e7cA-3db2A:
2.2		 1e7cA-3db2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE

(Trypanosoma
brucei) 		no annotation 4 ARG A  17
ALA A 158
ASP A 237
GLY A 241
 None
 0.98A 1e7cA-3hj4A:
undetectable		 1e7cA-3hj4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 ARG A 181
LYS A 178
ALA A 180
GLY A 147
 None
 1.23A 1e7cA-3hn2A:
2.4		 1e7cA-3hn2A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LYS A 109
ALA A 108
ASP A  88
GLY A  91
 None
 1.17A 1e7cA-3hskA:
undetectable		 1e7cA-3hskA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4

(Thermus
thermophilus) 		PF00346
(Complex1_49kDa) 		4 ARG 4 249
ALA 4 349
ASP 4 247
GLY 4 237
 None
 0.97A 1e7cA-3i9v4:
1.9		 1e7cA-3i9v4:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ing HOMOSERINE
DEHYDROGENASE

(Thermoplasma
acidophilum) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 ARG A 215
LYS A 216
ALA A 214
GLY A 210
 None
NDP  A 326 ( 4.5A)
None
None
 1.22A 1e7cA-3ingA:
undetectable		 1e7cA-3ingA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens;
synthetic
construct) 		PF00025
(Arf)
PF01412
(ArfGap)
PF12796
(Ank_2) 		4 ARG E  95
ALA E  99
ASP E  22
GLY E  20
 None
None
CA  E 739 (-4.9A)
None
 1.16A 1e7cA-3lvrE:
undetectable		 1e7cA-3lvrE:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 ARG A 112
ALA A 171
ASP A 449
GLY A 465
 SO4  A 506 (-3.1A)
None
None
None
 1.14A 1e7cA-3prlA:
undetectable		 1e7cA-3prlA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r67 PUTATIVE GLYCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		4 ARG A 258
ALA A 308
ASP A 263
GLY A 306
 None
 1.11A 1e7cA-3r67A:
undetectable		 1e7cA-3r67A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 ARG X 120
LYS X 118
ALA X 119
ASP X 108
 None
PLP  X 502 (-1.3A)
None
None
 1.19A 1e7cA-3ss7X:
undetectable		 1e7cA-3ss7X:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ARG A  54
LYS A  68
ALA A  69
GLY A 109
 None
 1.11A 1e7cA-3uj2A:
2.1		 1e7cA-3uj2A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9p THYMIDYLATE KINASE

(Burkholderia
thailandensis) 		PF02223
(Thymidylate_kin) 		4 ARG A  90
ALA A  89
ASP A  92
GLY A   4
 None
 1.08A 1e7cA-3v9pA:
undetectable		 1e7cA-3v9pA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 ARG A 494
ALA A 439
ASP A 492
GLY A 441
 None
EDO  A1533 (-3.8A)
None
EDO  A1526 (-3.7A)
 0.84A 1e7cA-4c1sA:
undetectable		 1e7cA-4c1sA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7x MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 15

([Candida]
glabrata) 		PF16987
(KIX_2) 		4 LYS A  39
ALA A  37
ASP A  33
GLY A  32
 None
 1.10A 1e7cA-4d7xA:
3.1		 1e7cA-4d7xA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di1 ENOYL-COA HYDRATASE
ECHA17

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 ARG A  44
ALA A  14
ASP A  46
GLY A  12
 None
 0.90A 1e7cA-4di1A:
undetectable		 1e7cA-4di1A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF07993
(NAD_binding_4) 		4 ARG A  87
ALA A 125
ASP A 127
GLY A 134
 None
 1.15A 1e7cA-4dqvA:
undetectable		 1e7cA-4dqvA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ARG A  52
LYS A  66
ALA A  67
GLY A 107
 None
 0.99A 1e7cA-4ewjA:
undetectable		 1e7cA-4ewjA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4w DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		4 ARG A 127
LYS A 128
ALA A 126
GLY A 122
 None
 1.12A 1e7cA-4f4wA:
undetectable		 1e7cA-4f4wA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f67 UPF0176 PROTEIN
LPG2838

(Legionella
pneumophila) 		PF00581
(Rhodanese) 		4 ARG A 229
ALA A  50
ASP A 227
GLY A  48
 None
 1.15A 1e7cA-4f67A:
undetectable		 1e7cA-4f67A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ARG A 731
ALA A 730
ASP A 732
GLY A 733
 None
 1.21A 1e7cA-4fgvA:
undetectable		 1e7cA-4fgvA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 LYS A 461
ALA A 459
ASP A 423
GLY A 457
 None
 1.19A 1e7cA-4fwtA:
4.1		 1e7cA-4fwtA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN
MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40)
PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 ARG A  44
LYS B 135
ASP B  89
GLY B  91
 None
 1.14A 1e7cA-4g56A:
undetectable		 1e7cA-4g56A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hav RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00638
(Ran_BP1) 		4 ARG B  90
ALA B  91
ASP B 129
GLY B 107
 None
 1.23A 1e7cA-4havB:
undetectable		 1e7cA-4havB:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		4 ARG A  63
ALA A  62
ASP A  65
GLY A  67
 None
 1.00A 1e7cA-4i8qA:
undetectable		 1e7cA-4i8qA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2u ANTIBODY LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG L  24
ALA L  25
ASP L  70
GLY L  68
 None
 1.03A 1e7cA-4k2uL:
undetectable		 1e7cA-4k2uL:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp2 HOMOACONITASE LARGE
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		4 ARG A 306
ALA A 333
ASP A 309
GLY A 300
 None
 0.72A 1e7cA-4kp2A:
undetectable		 1e7cA-4kp2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE

(Aspergillus
nidulans) 		PF16363
(GDP_Man_Dehyd) 		4 ARG A 312
ALA A 249
ASP A 241
GLY A 247
 IOD  A 405 (-3.7A)
UPG  A 401 (-3.2A)
None
None
 0.94A 1e7cA-4lisA:
undetectable		 1e7cA-4lisA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		4 LYS A  53
ALA A  52
ASP A  64
GLY A   6
 None
 1.12A 1e7cA-4mioA:
undetectable		 1e7cA-4mioA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		4 ARG A 308
ALA A 336
ASP A 311
GLY A 302
 None
 0.88A 1e7cA-4nqyA:
undetectable		 1e7cA-4nqyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfq HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Brachybacterium
faecium) 		PF00156
(Pribosyltran) 		4 ARG A 157
ALA A 154
ASP A 174
GLY A 172
 None
 1.05A 1e7cA-4pfqA:
undetectable		 1e7cA-4pfqA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pib INCLUSION BODY
PROTEIN

(Burkholderia
thailandensis) 		PF12306
(PixA) 		4 LYS A 157
ALA A 156
ASP A 109
GLY A 107
 None
None
None
CL  A 202 (-4.4A)
 1.15A 1e7cA-4pibA:
undetectable		 1e7cA-4pibA:
15.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 ARG A 209
ALA A 213
ASP A 324
GLY A 328
 NPS  A 602 (-3.6A)
NPS  A 602 (-3.3A)
NPS  A 602 ( 4.4A)
NPS  A 602 (-3.8A)
 0.57A 1e7cA-4po0A:
39.4		 1e7cA-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 LYS A 212
ALA A 213
ASP A 324
GLY A 328
 None
NPS  A 602 (-3.3A)
NPS  A 602 ( 4.4A)
NPS  A 602 (-3.8A)
 0.58A 1e7cA-4po0A:
39.4		 1e7cA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roq MALYL-COA
LYASE/BETA-METHYLMAL
YL-COA LYASE

(Methylobacterium
extorquens) 		PF03328
(HpcH_HpaI) 		4 ARG A  15
LYS A 317
ALA A 320
ASP A  37
 None
 1.17A 1e7cA-4roqA:
undetectable		 1e7cA-4roqA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		4 ARG A  86
ALA A  85
ASP A 347
GLY A  80
 None
 1.03A 1e7cA-4wgxA:
undetectable		 1e7cA-4wgxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvj ANTIBODY HEAVY CHAIN
VARIABLE DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		4 ARG H  38
ALA H  40
ASP H  90
GLY H 136
 None
 1.10A 1e7cA-4xvjH:
undetectable		 1e7cA-4xvjH:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		4 ARG A 419
LYS A 418
ALA A 420
ASP A 391
 None
 1.23A 1e7cA-5abmA:
undetectable		 1e7cA-5abmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqb DITRANS,POLYCIS-UNDE
CAPRENYL-DIPHOSPHATE
SYNTHASE
((2E,6E)-FARNESYL-DI
PHOSPHATE SPECIFIC)

(Escherichia
coli) 		PF01255
(Prenyltransf) 		4 ARG A  39
LYS A  33
ALA A  32
GLY A  27
 None
 1.03A 1e7cA-5cqbA:
undetectable		 1e7cA-5cqbA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4y HOMOSERINE
O-ACETYLTRANSFERASE

(Pseudomonas
veronii) 		PF00561
(Abhydrolase_1) 		4 ARG A 225
ALA A 330
ASP A 320
GLY A 327
 None
 1.15A 1e7cA-5e4yA:
undetectable		 1e7cA-5e4yA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc8 PRENYLTRANSFERENCE
FOR PROTEIN

(Lavandula
lanata) 		PF01255
(Prenyltransf) 		4 ARG A  79
LYS A  83
ALA A  82
GLY A  77
 PIS  A 402 (-4.4A)
None
None
PIS  A 402 (-3.2A)
 1.15A 1e7cA-5hc8A:
undetectable		 1e7cA-5hc8A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Paraburkholderia
graminis) 		PF13407
(Peripla_BP_4) 		4 LYS A 229
ALA A 228
ASP A 253
GLY A 224
 None
 1.11A 1e7cA-5hqjA:
undetectable		 1e7cA-5hqjA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idu ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Paraburkholderia
phymatum) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  86
ALA A 258
ASP A  97
GLY A 262
 None
 1.11A 1e7cA-5iduA:
3.0		 1e7cA-5iduA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsc PUTATIVE ACYL-COA
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  87
ALA A 259
ASP A  98
GLY A 263
 None
 1.11A 1e7cA-5jscA:
3.1		 1e7cA-5jscA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A 538
ALA A 510
ASP A 540
GLY A 501
 GAL  A1000 (-4.4A)
GAL  A1000 ( 4.4A)
None
None
 0.90A 1e7cA-5k6oA:
undetectable		 1e7cA-5k6oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmx DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT
RPAC1,DNA-DIRECTED
RNA POLYMERASES I
AND III SUBUNIT
RPAC1

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 LYS C 218
ALA C 217
ASP C 215
GLY C 213
 LYS  C 218 ( 0.0A)
ALA  C 217 ( 0.0A)
ASP  C 215 ( 0.6A)
GLY  C 213 ( 0.0A)
 1.17A 1e7cA-5lmxC:
2.1		 1e7cA-5lmxC:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mt2 BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ARG A 113
ALA A 170
ASP A 118
GLY A 168
 GOL  A 402 (-3.5A)
None
None
None
 0.94A 1e7cA-5mt2A:
undetectable		 1e7cA-5mt2A:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 4 ARG A 208
ALA A 212
ASP A 323
GLY A 327
 None
 0.34A 1e7cA-5oriA:
39.4		 1e7cA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 4 ARG A  70
ALA A 238
ASP A  73
GLY A 242
 None
 1.17A 1e7cA-5oynA:
undetectable		 1e7cA-5oynA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 ARG A  78
LYS A 313
ALA A 311
GLY A 525
 None
 1.14A 1e7cA-5u3cA:
undetectable		 1e7cA-5u3cA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzm GROUP IIE SECRETORY
PHOSPHOLIPASE A2

(Homo sapiens) 		no annotation 4 LYS A 107
ALA A 109
ASP A  37
GLY A  24
 None
None
None
CA  A 209 (-4.2A)
 1.16A 1e7cA-5wzmA:
undetectable		 1e7cA-5wzmA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION

(Mycolicibacterium
smegmatis) 		PF00383
(dCMP_cyt_deam_1) 		4 ARG A  47
ALA A  21
ASP A  44
GLY A  30
 None
 1.21A 1e7cA-5xkoA:
undetectable		 1e7cA-5xkoA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LYS A 844
ALA A 845
ASP A 848
GLY A1067
 None
 1.20A 1e7cA-5xogA:
3.1		 1e7cA-5xogA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 ARG A 209
LYS A 212
ALA A 213
ASP A 324
GLY A 328
 None
 0.47A 1e7cA-5yxeA:
36.9		 1e7cA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP2

(Escherichia
virus N4) 		no annotation 4 ARG B  91
ALA B  94
ASP B 389
GLY B  89
 None
 1.06A 1e7cA-6c2jB:
undetectable		 1e7cA-6c2jB:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dzs HOMOSERINE
DEHYDROGENASE

(Mycolicibacterium
hassiacum) 		no annotation 4 ARG A  72
ALA A  11
ASP A  74
GLY A   9
 None
 0.89A 1e7cA-6dzsA:
undetectable		 1e7cA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT RPAC1

(Saccharomyces
cerevisiae) 		no annotation 4 LYS C 218
ALA C 217
ASP C 215
GLY C 213
 None
 1.05A 1e7cA-6f42C:
undetectable		 1e7cA-6f42C:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 4 ARG D 361
ALA D 134
ASP D 335
GLY D 155
 None
 1.23A 1e7cA-6f5dD:
undetectable		 1e7cA-6f5dD:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 ARG A1406
ALA A1378
ASP A1374
GLY A1376
 None
 1.07A 1e7cA-6fb3A:
undetectable		 1e7cA-6fb3A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 ARG A1596
ALA A1566
ASP A1562
GLY A1564
 None
 1.14A 1e7cA-6fb3A:
undetectable		 1e7cA-6fb3A:
7.38