SIMILAR PATTERNS OF AMINO ACIDS FOR 1E7B_B_HLTB4002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 ARG A  55
ALA A  56
ALA A 274
GLU A 277
 None
 1.20A 1e7bB-1bjwA:
0.0		 1e7bB-1bjwA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c04 RIBOSOMAL PROTEIN
L11

(Haloarcula
marismortui) 		PF00298
(Ribosomal_L11) 		4 ARG C  41
ALA C  44
ALA C  58
GLU C  57
 None
None
A  E  30 ( 3.5A)
None
 1.09A 1e7bB-1c04C:
undetectable		 1e7bB-1c04C:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 ARG A 271
ALA A 267
ALA A 230
GLU A 226
 None
 1.17A 1e7bB-1fuiA:
undetectable		 1e7bB-1fuiA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 ARG A  13
ALA A 227
ALA A 331
GLU A 329
 None
 1.16A 1e7bB-1guqA:
undetectable		 1e7bB-1guqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 ARG A  13
ALA A 227
ALA A 332
GLU A 329
 None
 1.07A 1e7bB-1guqA:
undetectable		 1e7bB-1guqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		4 ARG A 183
ALA A 182
ALA A 219
GLU A 221
 None
 1.17A 1e7bB-1ktnA:
undetectable		 1e7bB-1ktnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no7 MAJOR CAPSID PROTEIN

(Human
alphaherpesvirus
1) 		PF03122
(Herpes_MCP) 		4 ARG A 660
ALA A 613
ALA A 688
GLU A 685
 None
 1.10A 1e7bB-1no7A:
undetectable		 1e7bB-1no7A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvt SHIKIMATE
5'-DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ARG A 141
ALA A 136
ALA A 165
GLU A 169
 None
NAP  A 288 (-4.2A)
None
None
 1.21A 1e7bB-1nvtA:
0.0		 1e7bB-1nvtA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1l CHORISMATE SYNTHASE

(Aquifex
aeolicus) 		PF01264
(Chorismate_synt) 		4 ARG A  43
ALA A 147
ALA A 365
GLU A 361
 None
 1.22A 1e7bB-1q1lA:
0.5		 1e7bB-1q1lA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE

(Enterococcus
faecium) 		PF01427
(Peptidase_M15) 		4 ARG A 147
ALA A 152
ALA A 160
GLU A 159
 None
 0.90A 1e7bB-1r44A:
undetectable		 1e7bB-1r44A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1f PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 ARG A 103
ALA A 221
ALA A 232
GLU A 231
 None
 1.08A 1e7bB-1s1fA:
0.4		 1e7bB-1s1fA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA

(Archaeoglobus
fulgidus) 		PF01008
(IF-2B) 		4 ARG A 100
ALA A  55
ALA A 126
GLU A 128
 None
 1.07A 1e7bB-1t5oA:
undetectable		 1e7bB-1t5oA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		4 ARG A 100
ALA A  58
ALA A 126
GLU A 128
 None
 0.96A 1e7bB-1t9kA:
undetectable		 1e7bB-1t9kA:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 ARG A 209
ALA A 213
ALA A 350
GLU A 354
 DKA  A1001 ( 4.6A)
DKA  A1001 ( 4.0A)
DKA  A1002 ( 3.8A)
DKA  A1002 ( 4.4A)
 0.36A 1e7bB-1tf0A:
47.7		 1e7bB-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5v CITE

(Mycobacterium
tuberculosis) 		PF03328
(HpcH_HpaI) 		4 ARG A 149
ALA A 136
ALA A 180
GLU A 194
 None
 1.11A 1e7bB-1u5vA:
undetectable		 1e7bB-1u5vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 ARG A 176
ALA A 177
ALA A 139
GLU A 140
 None
 1.13A 1e7bB-1ub3A:
undetectable		 1e7bB-1ub3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 ARG A 176
ALA A 177
ALA A 142
GLU A 140
 None
 1.15A 1e7bB-1ub3A:
undetectable		 1e7bB-1ub3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ARG A 186
ALA A 189
ALA A 213
GLU A 215
 None
KCX  A 188 ( 3.7A)
None
None
 1.17A 1e7bB-1w78A:
undetectable		 1e7bB-1w78A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxd SHIKIMATE
5-DEHYDROGENASE

(Thermus
thermophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ARG A 129
ALA A 124
ALA A 154
GLU A 158
 None
 1.26A 1e7bB-1wxdA:
undetectable		 1e7bB-1wxdA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3
RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens;
Mus musculus) 		PF00104
(Hormone_recep) 		4 ARG E 282
ALA A 424
ALA E 327
GLU E 210
 None
 1.24A 1e7bB-1xlsE:
2.1		 1e7bB-1xlsE:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 ARG A 151
ALA A 150
ALA A   7
GLU A   5
 None
 0.65A 1e7bB-1yirA:
undetectable		 1e7bB-1yirA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		4 ARG A 529
ALA A 517
ALA A 440
GLU A 441
 None
 1.19A 1e7bB-2eaeA:
undetectable		 1e7bB-2eaeA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE

(Thermus
thermophilus) 		PF00596
(Aldolase_II) 		4 ARG A 144
ALA A  83
ALA A 165
GLU A 168
 None
 1.16A 1e7bB-2fk5A:
undetectable		 1e7bB-2fk5A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hbo HYPOTHETICAL PROTEIN
(NP_422103.1)

(Caulobacter
vibrioides) 		PF03061
(4HBT) 		4 ARG A 144
ALA A 143
ALA A 152
GLU A 150
 None
 1.12A 1e7bB-2hboA:
undetectable		 1e7bB-2hboA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ARG A 783
ALA A 755
ALA A 762
GLU A 761
 None
 1.17A 1e7bB-2hpiA:
undetectable		 1e7bB-2hpiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		4 ARG A 295
ALA A 257
ALA A 228
GLU A 232
 None
 1.21A 1e7bB-2hxgA:
undetectable		 1e7bB-2hxgA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idx COB(I)YRINIC ACID
A,C-DIAMIDE
ADENOSYLTRANSFERASE

(Homo sapiens) 		PF01923
(Cob_adeno_trans) 		4 ARG A 191
ALA A 187
ALA A  95
GLU A  91
 None
 1.07A 1e7bB-2idxA:
3.3		 1e7bB-2idxA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kcv TETRATRICOPEPTIDE
REPEAT DOMAIN
PROTEIN

(Salinibacter
ruber) 		PF14559
(TPR_19) 		4 ARG A   9
ALA A  13
ALA A  27
GLU A  31
 None
 1.20A 1e7bB-2kcvA:
2.2		 1e7bB-2kcvA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oix XANTHOMONAS OUTER
PROTEIN D

(Xanthomonas
euvesicatoria) 		PF02902
(Peptidase_C48) 		4 ARG A 354
ALA A 352
ALA A 482
GLU A 479
 None
 1.26A 1e7bB-2oixA:
undetectable		 1e7bB-2oixA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6c AQ_2013 PROTEIN

(Aquifex
aeolicus) 		PF01894
(UPF0047) 		4 ARG A  16
ALA A  89
ALA A  71
GLU A  68
 None
 1.26A 1e7bB-2p6cA:
undetectable		 1e7bB-2p6cA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 ARG A 480
ALA A 482
ALA A 490
GLU A 489
 ADP  A1001 (-3.6A)
None
None
ADP  A1001 ( 4.8A)
 0.97A 1e7bB-2r6fA:
1.8		 1e7bB-2r6fA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcd UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF11533
(DUF3225) 		4 ARG A  21
ALA A  25
ALA A  32
GLU A  36
 None
 1.24A 1e7bB-2rcdA:
undetectable		 1e7bB-2rcdA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ARG G1590
ALA G1655
ALA G1598
GLU G1594
 None
 1.13A 1e7bB-2uv8G:
0.3		 1e7bB-2uv8G:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A 326
ALA A 328
ALA A 291
GLU A 292
 None
 1.08A 1e7bB-2wbiA:
undetectable		 1e7bB-2wbiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 ARG A 456
ALA A 480
ALA A 353
GLU A 355
 None
 1.17A 1e7bB-2zpaA:
undetectable		 1e7bB-2zpaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak4 NADH-DEPENDENT
QUINUCLIDINONE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		4 ARG A 205
ALA A 202
ALA A 211
GLU A 215
 None
 1.16A 1e7bB-3ak4A:
undetectable		 1e7bB-3ak4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		4 ARG A  20
ALA A  23
ALA A 221
GLU A 218
 None
 1.12A 1e7bB-3edmA:
undetectable		 1e7bB-3edmA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h75 PERIPLASMIC
SUGAR-BINDING DOMAIN
PROTEIN

(Pseudomonas
protegens) 		PF13407
(Peripla_BP_4) 		4 ARG A 225
ALA A 253
ALA A 285
GLU A 281
 None
 1.12A 1e7bB-3h75A:
undetectable		 1e7bB-3h75A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h90 FERROUS-IRON EFFLUX
PUMP FIEF

(Escherichia
coli) 		PF01545
(Cation_efflux)
PF16916
(ZT_dimer) 		4 ARG A 148
ALA A 149
ALA A 201
GLU A 200
 None
 1.09A 1e7bB-3h90A:
undetectable		 1e7bB-3h90A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 ARG A  87
ALA A  86
ALA A 114
GLU A 116
 None
 1.12A 1e7bB-3i09A:
undetectable		 1e7bB-3i09A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE

(Brucella
melitensis) 		PF02569
(Pantoate_ligase) 		4 ARG A 169
ALA A 144
ALA A  44
GLU A  47
 None
 1.24A 1e7bB-3innA:
undetectable		 1e7bB-3innA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5f N-CARBAMOYL-L-AMINO
ACID HYDROLASE

(Geobacillus
stearothermophilus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ARG A  35
ALA A  37
ALA A 120
GLU A  54
 None
 1.23A 1e7bB-3n5fA:
2.4		 1e7bB-3n5fA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 ARG B 946
ALA B 769
ALA B 823
GLU B 786
 None
 1.09A 1e7bB-3o8oB:
undetectable		 1e7bB-3o8oB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9x PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Bacillus
halodurans) 		PF00551
(Formyl_trans_N) 		4 ARG A 176
ALA A 180
ALA A 151
GLU A 153
 SO4  A 214 (-4.4A)
None
None
None
 0.90A 1e7bB-3p9xA:
undetectable		 1e7bB-3p9xA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 ARG A 249
ALA A 194
ALA A 154
GLU A 157
 None
 1.00A 1e7bB-3ppiA:
undetectable		 1e7bB-3ppiA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Staphylococcus
aureus) 		PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11) 		4 ARG A 255
ALA A 158
ALA A 274
GLU A 270
 None
 1.18A 1e7bB-3rkxA:
undetectable		 1e7bB-3rkxA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		4 ARG A 451
ALA A 449
ALA A 435
GLU A  26
 None
 0.88A 1e7bB-3sfwA:
undetectable		 1e7bB-3sfwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 ARG A 341
ALA A 345
ALA A 357
GLU A 361
 None
 1.12A 1e7bB-3tqoA:
2.4		 1e7bB-3tqoA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ARG A 413
ALA A 414
ALA A 344
GLU A 348
 None
 1.07A 1e7bB-3ue3A:
undetectable		 1e7bB-3ue3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 ARG A 140
ALA A 144
ALA A 389
GLU A 391
 None
 1.03A 1e7bB-3uszA:
undetectable		 1e7bB-3uszA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1o ROQUIN-1

(Homo sapiens) 		no annotation 4 ARG A 251
ALA A 189
ALA A 294
GLU A 293
 None
 1.22A 1e7bB-3x1oA:
undetectable		 1e7bB-3x1oA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Synechococcus
elongatus) 		PF13561
(adh_short_C2) 		4 ARG A 212
ALA A 192
ALA A 216
GLU A 218
 None
 1.08A 1e7bB-4dmmA:
undetectable		 1e7bB-4dmmA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 ARG A 329
ALA A  61
ALA A 144
GLU A 143
 None
 1.26A 1e7bB-4dvjA:
undetectable		 1e7bB-4dvjA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 ARG A 344
ALA A 345
ALA A 330
GLU A 295
 None
 0.85A 1e7bB-4dykA:
undetectable		 1e7bB-4dykA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		4 ARG A 153
ALA A 154
ALA A 258
GLU A 263
 None
 1.05A 1e7bB-4glfA:
undetectable		 1e7bB-4glfA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iit PHENYLACETATE-COA
OXYGENASE SUBUNIT
PAAB
PHENYLACETATE-COA
OXYGENASE SUBUNIT
PAAC

(Klebsiella
pneumoniae) 		PF05138
(PaaA_PaaC)
PF06243
(PaaB) 		4 ARG C 146
ALA B  30
ALA B  35
GLU B  37
 None
 0.92A 1e7bB-4iitC:
undetectable		 1e7bB-4iitC:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jig DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		4 ARG A  30
ALA A  27
ALA A 228
GLU A 229
 None
 1.09A 1e7bB-4jigA:
undetectable		 1e7bB-4jigA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ARG A 244
ALA A 305
ALA A 379
GLU A 381
 None
 1.00A 1e7bB-4lbwA:
undetectable		 1e7bB-4lbwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		4 ARG A 255
ALA A 211
ALA A 263
GLU A 262
 None
 1.06A 1e7bB-4llsA:
undetectable		 1e7bB-4llsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE

(Staphylococcus
aureus) 		PF02423
(OCD_Mu_crystall) 		4 ARG A  10
ALA A 115
ALA A  95
GLU A  93
 None
 1.10A 1e7bB-4mp3A:
undetectable		 1e7bB-4mp3A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7b LYTB

(Plasmodium
falciparum) 		PF02401
(LYTB) 		4 ARG A 202
ALA A 205
ALA A 296
GLU A 298
 None
 1.12A 1e7bB-4n7bA:
undetectable		 1e7bB-4n7bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B

(Streptococcus
thermophilus) 		PF02421
(FeoB_N) 		4 ARG A 197
ALA A 200
ALA A 179
GLU A 177
 ARG  A 197 ( 0.6A)
ALA  A 200 ( 0.0A)
ALA  A 179 ( 0.0A)
GLU  A 177 ( 0.6A)
 0.97A 1e7bB-4nonA:
undetectable		 1e7bB-4nonA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		4 ARG A 267
ALA A 271
ALA A  58
GLU A  62
 None
 1.02A 1e7bB-4oanA:
undetectable		 1e7bB-4oanA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A 853
ALA A1041
ALA A1012
GLU A1010
 None
 1.12A 1e7bB-4rcnA:
undetectable		 1e7bB-4rcnA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ARG A  32
ALA A 187
ALA A  38
GLU A 117
 None
 1.13A 1e7bB-4u8hA:
undetectable		 1e7bB-4u8hA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 ARG L 160
ALA L 154
ALA L 210
GLU L 214
 None
 1.02A 1e7bB-4u9iL:
undetectable		 1e7bB-4u9iL:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 ARG A 109
ALA A 105
ALA A 141
GLU A 145
 None
 0.97A 1e7bB-4v1yA:
undetectable		 1e7bB-4v1yA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		4 ARG A 380
ALA A 376
ALA A 313
GLU A 314
 None
 1.13A 1e7bB-4wj3A:
undetectable		 1e7bB-4wj3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0a SHIKIMATE KINASE

(Acinetobacter
baumannii) 		PF01202
(SKI) 		4 ARG A 173
ALA A 176
ALA A  39
GLU A  40
 None
 1.10A 1e7bB-4y0aA:
undetectable		 1e7bB-4y0aA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt9 PEPTIDYLARGININE
DEIMINASE

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		4 ARG A  56
ALA A 136
ALA A 357
GLU A  62
 GOL  A 505 (-4.9A)
None
None
None
 1.24A 1e7bB-4yt9A:
undetectable		 1e7bB-4yt9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 ARG A 206
ALA A 234
ALA A 260
GLU A 259
 None
 1.10A 1e7bB-4yv7A:
undetectable		 1e7bB-4yv7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ARG A 150
ALA A 139
ALA A 273
GLU A 195
 None
 0.90A 1e7bB-4yzoA:
undetectable		 1e7bB-4yzoA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlc ROQUIN-2

(Homo sapiens) 		no annotation 4 ARG A 248
ALA A 186
ALA A 291
GLU A 290
 None
 1.14A 1e7bB-4zlcA:
undetectable		 1e7bB-4zlcA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Pyrobaculum
calidifontis) 		PF13685
(Fe-ADH_2) 		4 ARG A 325
ALA A 328
ALA A 304
GLU A 303
 None
 1.23A 1e7bB-5fb3A:
undetectable		 1e7bB-5fb3A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		4 ARG A 296
ALA A 299
ALA A 163
GLU A 169
 None
 0.87A 1e7bB-5ghsA:
undetectable		 1e7bB-5ghsA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiw CYTOCHROME P450
CYP260B1

(Sorangium
cellulosum) 		PF00067
(p450) 		4 ARG A 205
ALA A 209
ALA A  89
GLU A 202
 None
 1.24A 1e7bB-5hiwA:
undetectable		 1e7bB-5hiwA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 ARG A 292
ALA A 290
ALA A 117
GLU A 115
 None
 1.04A 1e7bB-5i5lA:
1.7		 1e7bB-5i5lA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA

(Homo sapiens) 		PF08332
(CaMKII_AD) 		4 ARG A 469
ALA A 379
ALA A 384
GLU A 383
 None
 1.20A 1e7bB-5ig3A:
undetectable		 1e7bB-5ig3A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdq CHITOPORIN

(Vibrio harveyi) 		no annotation 4 ARG A 330
ALA A 211
ALA A 246
GLU A 252
 None
 0.89A 1e7bB-5mdqA:
undetectable		 1e7bB-5mdqA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4

(Human
alphaherpesvirus
1) 		PF03584
(Herpes_ICP4_N) 		4 ARG A 336
ALA A 406
ALA A 345
GLU A 365
 None
 1.15A 1e7bB-5mhjA:
undetectable		 1e7bB-5mhjA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhk RS1

(Human
alphaherpesvirus
1) 		PF03584
(Herpes_ICP4_N) 		4 ARG A 336
ALA A 406
ALA A 345
GLU A 365
 None
 1.16A 1e7bB-5mhkA:
undetectable		 1e7bB-5mhkA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL

(Homo sapiens) 		PF01180
(DHO_dh) 		4 ARG A  57
ALA A  59
ALA A 104
GLU A 103
 None
U91  A 403 (-3.3A)
None
None
 1.07A 1e7bB-5mvdA:
undetectable		 1e7bB-5mvdA:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 4 ARG A 208
ALA A 212
ALA A 349
GLU A 353
 None
 0.18A 1e7bB-5oriA:
45.7		 1e7bB-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1q N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
DOMAIN-CONTAINING
PROTEIN
SAOUHSC_02979

(Staphylococcus
aureus) 		PF01832
(Glucosaminidase)
PF05257
(CHAP) 		4 ARG A 292
ALA A 361
ALA A 349
GLU A 352
 None
 1.10A 1e7bB-5t1qA:
1.8		 1e7bB-5t1qA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		4 ARG A 288
ALA A 287
ALA A 331
GLU A 333
 None
 1.15A 1e7bB-5upyA:
undetectable		 1e7bB-5upyA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ARG A 102
ALA A 103
ALA A 290
GLU A 289
 None
 1.08A 1e7bB-5w4xA:
undetectable		 1e7bB-5w4xA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w75 ELONGATION FACTOR TU

(Thermotoga
neapolitana) 		no annotation 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 1.03A 1e7bB-5w75A:
undetectable		 1e7bB-5w75A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 0.99A 1e7bB-5w76A:
undetectable		 1e7bB-5w76A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 0.96A 1e7bB-5w7qA:
undetectable		 1e7bB-5w7qA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 4 ARG A 265
ALA A 264
ALA A  18
GLU A  15
 None
 0.96A 1e7bB-5wabA:
undetectable		 1e7bB-5wabA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk0 DAMAGE-INDUCIBLE
PROTEIN DINB

(Staphylococcus
sp. HMSC055H04) 		no annotation 4 ARG A 102
ALA A 103
ALA A  55
GLU A  53
 None
 1.15A 1e7bB-5wk0A:
undetectable		 1e7bB-5wk0A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 4 ARG A 138
ALA A 134
ALA A 168
GLU A 172
 None
 1.18A 1e7bB-5wt4A:
undetectable		 1e7bB-5wt4A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 ARG A 295
ALA A 298
ALA A 162
GLU A 168
 None
 0.90A 1e7bB-5x4jA:
undetectable		 1e7bB-5x4jA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 4 ARG A 209
ALA A 213
ALA A 350
GLU A 354
 None
 0.43A 1e7bB-5yxeA:
47.6		 1e7bB-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9a CHORISMATE SYNTHASE

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A  47
ALA A 139
ALA A 336
GLU A 332
 None
 1.22A 1e7bB-5z9aA:
undetectable		 1e7bB-5z9aA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6m CYANATE HYDRATASE

(Serratia
proteamaculans) 		no annotation 4 ARG A  59
ALA A  58
ALA A  71
GLU A  69
 None
 1.08A 1e7bB-6b6mA:
undetectable		 1e7bB-6b6mA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 4 ARG A 700
ALA A 699
ALA A 681
GLU A 686
 None
 1.00A 1e7bB-6bfiA:
3.5		 1e7bB-6bfiA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 4 ARG A 216
ALA A 501
ALA A 483
GLU A 493
 None
 1.07A 1e7bB-6dk2A:
undetectable		 1e7bB-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gqd GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Homo sapiens) 		no annotation 4 ARG A  33
ALA A 247
ALA A 354
GLU A 352
 None
 1.12A 1e7bB-6gqdA:
undetectable		 1e7bB-6gqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9rub RIBULOSE-1,5-BISPHOS
PHATE CARBOXYLASE

(Rhodospirillum
rubrum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 217
ALA A 218
ALA A 182
GLU A 178
 None
 1.16A 1e7bB-9rubA:
undetectable		 1e7bB-9rubA:
21.99