SIMILAR PATTERNS OF AMINO ACIDS FOR 1E7B_B_HLTB4001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 ARG A 289
LYS A 291
ASP A 306
GLY A 304
 ARG  A 289 ( 0.6A)
LYS  A 291 ( 0.0A)
ASP  A 306 ( 0.5A)
GLY  A 304 ( 0.0A)
 1.28A 1e7bB-1fxjA:
0.0		 1e7bB-1fxjA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npc NEUTRAL PROTEASE

(Bacillus cereus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 ARG A  91
LYS A  86
ASP A  96
GLY A  98
 None
 1.46A 1e7bB-1npcA:
2.2		 1e7bB-1npcA:
19.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 ARG A 209
LYS A 212
ASP A 324
GLY A 328
 DKA  A1001 ( 4.6A)
None
DKA  A1001 (-4.7A)
DKA  A1001 ( 4.1A)
 0.52A 1e7bB-1tf0A:
47.7		 1e7bB-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL) 		4 ARG A 592
LYS A 593
ASP A 588
GLY A 705
 None
 1.41A 1e7bB-2vdwA:
0.0		 1e7bB-2vdwA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n ASPARTATE
CARBAMOYLTRANSFERASE

(Aquifex
aeolicus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ARG B 240
LYS B 243
ASP B 200
GLY B 202
 None
 1.19A 1e7bB-3d6nB:
0.0		 1e7bB-3d6nB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejn SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 ARG A 440
LYS A  58
ASP A 298
GLY A 297
 None
 1.44A 1e7bB-3ejnA:
0.1		 1e7bB-3ejnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC4

(Schizosaccharomyces
pombe) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF03604
(DNA_RNApol_7kD) 		4 ARG L  63
LYS C 170
ASP C  46
GLY C 163
 None
 1.03A 1e7bB-3h0gL:
undetectable		 1e7bB-3h0gL:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 ARG A 614
LYS A 561
ASP A 612
GLY A 611
 None
 1.45A 1e7bB-3s29A:
0.0		 1e7bB-3s29A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 113
LYS A 338
ASP A 142
GLY A 140
 None
 1.47A 1e7bB-3t8qA:
0.2		 1e7bB-3t8qA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN
MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40)
PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 ARG A  44
LYS B 135
ASP B  89
GLY B  91
 None
 1.17A 1e7bB-4g56A:
0.0		 1e7bB-4g56A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 ARG A 188
LYS A 172
ASP A 189
GLY A 190
 None
 1.29A 1e7bB-5dkxA:
undetectable		 1e7bB-5dkxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		4 ARG A  90
LYS A  80
ASP A  92
GLY A  93
 None
 1.41A 1e7bB-5h6sA:
undetectable		 1e7bB-5h6sA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jki PUTATIVE LIPID
PHOSPHATE
PHOSPHATASE YODM

(Bacillus
subtilis) 		PF01569
(PAP2) 		4 ARG A 101
LYS A  96
ASP A 175
GLY A 178
 None
WO4  A 300 (-2.2A)
None
None
 1.06A 1e7bB-5jkiA:
undetectable		 1e7bB-5jkiA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 4 ARG A 209
LYS A 212
ASP A 324
GLY A 328
 None
 0.57A 1e7bB-5yxeA:
47.6		 1e7bB-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exn PRE-MRNA-SPLICING
FACTOR CWC2

(Saccharomyces
cerevisiae) 		no annotation 4 ARG M 131
LYS M 132
ASP M 119
GLY M 128
 None
None
None
G  6  39 ( 3.3A)
 1.46A 1e7bB-6exnM:
undetectable		 1e7bB-6exnM:
7.35