SIMILAR PATTERNS OF AMINO ACIDS FOR 1E7B_A_HLTA4003

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN)

(Cupriavidus
necator) 		PF00101
(RuBisCO_small) 		5 ILE I  68
LEU I  58
VAL I  33
GLY I  34
LEU I  23
 None
 1.15A 1e7bA-1bxnI:
undetectable		 1e7bA-1bxnI:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A  93
VAL A 175
GLY A 176
CYH A 123
LEU A   3
 None
 1.18A 1e7bA-1cqjA:
undetectable		 1e7bA-1cqjA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1r HYPOTHETICAL 11.4 KD
PROTEIN YCIH IN
PYRF-OSMB INTERGENIC
REGION

(Escherichia
coli) 		PF01253
(SUI1) 		5 ILE A  83
LEU A  97
VAL A  54
GLY A  53
LEU A  64
 None
 1.13A 1e7bA-1d1rA:
undetectable		 1e7bA-1d1rA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3

(Mus musculus) 		PF00025
(Arf) 		5 ILE A  89
LEU A  10
VAL A 166
GLY A 169
LEU A  37
 None
 1.12A 1e7bA-1fzqA:
undetectable		 1e7bA-1fzqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3

(Mus musculus) 		PF00025
(Arf) 		5 LEU A 122
VAL A 166
GLY A 165
ALA A 160
LEU A  33
 None
None
None
GDP  A 301 (-3.7A)
None
 0.93A 1e7bA-1fzqA:
undetectable		 1e7bA-1fzqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		5 ILE P 236
LEU P 247
VAL P 323
GLY P 322
ALA P 320
 None
 1.15A 1e7bA-1h71P:
0.8		 1e7bA-1h71P:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 ILE A 254
LEU A 312
VAL A 229
ALA A 216
LEU A 219
 None
 1.15A 1e7bA-1khdA:
0.3		 1e7bA-1khdA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 ILE A  66
LEU A 336
GLY A  19
ALA A  23
LEU A 333
 None
ATP  A 450 (-4.8A)
None
None
None
 1.12A 1e7bA-1kyiA:
undetectable		 1e7bA-1kyiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		5 ILE A   8
LEU A 386
VAL A 379
ALA A  18
LEU A  22
 None
 1.01A 1e7bA-1lqtA:
undetectable		 1e7bA-1lqtA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx3 C-TERMINAL BINDING
PROTEIN 1

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 339
VAL A  30
GLY A  72
ALA A  49
LEU A  45
 None
 1.11A 1e7bA-1mx3A:
undetectable		 1e7bA-1mx3A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 300
VAL A 238
GLY A 239
ALA A 355
LEU A 352
 None
 1.15A 1e7bA-1n7gA:
undetectable		 1e7bA-1n7gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		5 ILE A 134
VAL A 197
GLY A 196
ALA A 199
LEU A 249
 None
 1.06A 1e7bA-1nbwA:
0.3		 1e7bA-1nbwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 ILE A 205
VAL A 509
GLY A 510
ALA A 486
LEU A 451
 None
 0.96A 1e7bA-1nowA:
undetectable		 1e7bA-1nowA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4w PIN (PILT
N-TERMINUS) DOMAIN

(Archaeoglobus
fulgidus) 		no annotation 5 ILE A 101
LEU A 123
VAL A  16
ALA A  14
LEU A  35
 None
 1.16A 1e7bA-1o4wA:
undetectable		 1e7bA-1o4wA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ooe DIHYDROPTERIDINE
REDUCTASE

(Caenorhabditis
elegans) 		PF00106
(adh_short) 		5 LEU A  31
VAL A  76
GLY A  75
ALA A 115
LEU A 114
 None
 1.15A 1e7bA-1ooeA:
undetectable		 1e7bA-1ooeA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9h PROBABLE GTPASE ENGC

(Bacillus
subtilis) 		PF03193
(RsgA_GTPase)
PF16745
(RsgA_N) 		5 ILE A 109
LEU A 228
GLY A 224
ALA A  81
LEU A  83
 None
 0.92A 1e7bA-1t9hA:
undetectable		 1e7bA-1t9hA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 ILE A 388
ASN A 391
LEU A 407
VAL A 433
GLY A 434
ALA A 449
LEU A 453
 None
 0.57A 1e7bA-1tf0A:
47.7		 1e7bA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 ILE A 388
ASN A 391
PHE A 403
LEU A 407
GLY A 434
ALA A 449
LEU A 453
 None
 0.44A 1e7bA-1tf0A:
47.7		 1e7bA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 LEU A 235
VAL A  47
GLY A  48
ALA A 161
LEU A 164
 None
 1.10A 1e7bA-1v5vA:
undetectable		 1e7bA-1v5vA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpx PROTEIN
(TRANSALDOLASE (EC
2.2.1.2))

(Thermotoga
maritima) 		PF00923
(TAL_FSA) 		5 ILE A  84
VAL A  67
GLY A  65
ALA A  93
LEU A  97
 None
 1.14A 1e7bA-1vpxA:
undetectable		 1e7bA-1vpxA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 ASN A 593
LEU A 327
GLY A 323
ALA A 489
LEU A 335
 None
None
None
GDP  A1002 (-3.4A)
None
 1.15A 1e7bA-1xjeA:
undetectable		 1e7bA-1xjeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bhv COMB10

(Helicobacter
pylori) 		PF03743
(TrbI) 		5 LEU A 233
VAL A 194
GLY A 220
ALA A 196
LEU A 182
 None
 0.89A 1e7bA-2bhvA:
undetectable		 1e7bA-2bhvA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1p HYPOTHETICAL PROTEIN
YHEL

(Escherichia
coli) 		PF04077
(DsrH) 		5 ILE C  74
VAL C  34
GLY C  33
ALA C  56
LEU C  61
 None
 1.19A 1e7bA-2d1pC:
undetectable		 1e7bA-2d1pC:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		5 LEU A 259
VAL A 279
GLY A 280
ALA A 275
LEU A  27
 None
 1.19A 1e7bA-2ef4A:
undetectable		 1e7bA-2ef4A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ged SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF09439
(SRPRB) 		5 PHE A 114
LEU A 132
VAL A 221
ALA A 219
LEU A 217
 None
 1.17A 1e7bA-2gedA:
undetectable		 1e7bA-2gedA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B

(Homo sapiens) 		no annotation 5 ILE M 205
VAL N 509
GLY N 510
ALA N 486
LEU N 451
 None
 1.06A 1e7bA-2gk1M:
undetectable		 1e7bA-2gk1M:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		5 ILE A 342
LEU A 238
VAL A 232
ALA A 318
LEU A 321
 None
 1.17A 1e7bA-2nxxA:
undetectable		 1e7bA-2nxxA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ome C-TERMINAL-BINDING
PROTEIN 2

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 345
VAL A  36
GLY A  78
ALA A  55
LEU A  51
 None
 1.05A 1e7bA-2omeA:
undetectable		 1e7bA-2omeA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 169
VAL A 179
GLY A 177
ALA A 210
LEU A 214
 None
 1.14A 1e7bA-2oqhA:
undetectable		 1e7bA-2oqhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pdz SYNTROPHIN

(Mus musculus) 		PF00595
(PDZ) 		5 ILE A  28
LEU A  45
VAL A  54
ALA A  67
LEU A  71
 None
 1.15A 1e7bA-2pdzA:
undetectable		 1e7bA-2pdzA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 461
VAL A 413
GLY A 412
ALA A 427
LEU A 454
 None
 1.07A 1e7bA-2qaeA:
undetectable		 1e7bA-2qaeA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxg CG6181-PA, ISOFORM A

(Drosophila
melanogaster) 		no annotation 5 ILE A1222
LEU A1289
VAL A1247
GLY A1245
ALA A1238
 None
 1.18A 1e7bA-2vxgA:
undetectable		 1e7bA-2vxgA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE B 118
LEU B  86
GLY B  38
ALA B 116
LEU B  52
 None
 1.17A 1e7bA-2w55B:
undetectable		 1e7bA-2w55B:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		5 ILE A 535
ASN A 538
PHE A 541
LEU A 478
GLY A 567
 None
 0.87A 1e7bA-2x9xA:
undetectable		 1e7bA-2x9xA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		5 ILE A 775
LEU A 646
VAL A 818
GLY A 817
LEU A 683
 None
 1.11A 1e7bA-3aibA:
undetectable		 1e7bA-3aibA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		5 ILE A 274
LEU A 323
GLY A 293
ALA A 238
LEU A 239
 None
 1.02A 1e7bA-3b9yA:
undetectable		 1e7bA-3b9yA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh6 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3

(Mus musculus) 		PF00025
(Arf) 		5 LEU A 122
VAL A 166
GLY A 165
ALA A 160
LEU A  33
 None
None
None
GNP  A   1 (-3.7A)
None
 0.97A 1e7bA-3bh6A:
undetectable		 1e7bA-3bh6A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 186
VAL A 235
GLY A 236
ALA A 177
LEU A 173
 None
 0.94A 1e7bA-3cpsA:
undetectable		 1e7bA-3cpsA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ILE A 716
LEU A 984
VAL A 746
GLY A 745
ALA A 695
 None
 1.01A 1e7bA-3dy5A:
undetectable		 1e7bA-3dy5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ILE A 652
PHE A 693
VAL A 621
ALA A 406
LEU A 623
 None
 0.99A 1e7bA-3f2bA:
undetectable		 1e7bA-3f2bA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fca CYSTEINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 ILE A 226
VAL A 165
GLY A 168
ALA A 190
LEU A 199
 None
 1.07A 1e7bA-3fcaA:
undetectable		 1e7bA-3fcaA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 767
VAL A 578
GLY A 579
ALA A 748
LEU A 749
 None
 1.03A 1e7bA-3hhdA:
undetectable		 1e7bA-3hhdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd9 COENZYME A DISULFIDE
REDUCTASE

(Pyrococcus
horikoshii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 440
VAL A 388
GLY A 387
ALA A 402
LEU A 433
 None
 1.15A 1e7bA-3kd9A:
undetectable		 1e7bA-3kd9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcq THIAMINE-MONOPHOSPHA
TE KINASE

(Methylobacillus
flagellatus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ILE A 291
VAL A 229
GLY A 289
ALA A 227
LEU A 216
 None
 1.18A 1e7bA-3mcqA:
undetectable		 1e7bA-3mcqA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1

(Bos taurus) 		PF00481
(PP2C) 		5 ILE A 176
LEU A 324
GLY A 200
CYH A  80
ALA A 197
 None
 1.00A 1e7bA-3mq3A:
undetectable		 1e7bA-3mq3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwy URIDYLATE KINASE

(Mycobacterium
tuberculosis) 		PF00696
(AA_kinase) 		5 PHE A  42
LEU A 111
GLY A  38
ALA A 184
LEU A  35
 None
 1.14A 1e7bA-3nwyA:
undetectable		 1e7bA-3nwyA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		5 ILE A 432
PHE A 508
LEU A 512
GLY A  41
ALA A 114
 HEA  A   1 ( 4.6A)
HEA  A   1 (-4.6A)
None
HEA  A   1 ( 4.1A)
HEA  A   1 ( 4.0A)
 1.18A 1e7bA-3omnA:
undetectable		 1e7bA-3omnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdk PHOSPHOGLUCOSAMINE
MUTASE

(Bacillus
anthracis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ILE A 264
LEU A 237
VAL A 256
ALA A 363
LEU A 359
 None
 1.15A 1e7bA-3pdkA:
undetectable		 1e7bA-3pdkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q41 GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
ZETA-1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 LEU A  91
VAL A 287
GLY A 286
ALA A 291
LEU A 325
 None
 1.12A 1e7bA-3q41A:
undetectable		 1e7bA-3q41A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 ILE A 277
VAL A 233
GLY A 249
ALA A 235
LEU A 286
 None
 1.19A 1e7bA-3qo6A:
undetectable		 1e7bA-3qo6A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qta CHEMOTAXIS PROTEIN
CHEC

(Haloarcula
marismortui) 		PF13690
(CheX) 		5 ILE A 169
LEU A 178
VAL A  38
ALA A  36
LEU A  28
 None
 1.01A 1e7bA-3qtaA:
undetectable		 1e7bA-3qtaA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpk BACKBONE PILUS
SUBUNIT

(Streptococcus
pneumoniae) 		PF16555
(GramPos_pilinD1)
PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		5 ILE A 535
ASN A 538
PHE A 541
LEU A 478
GLY A 567
 None
 0.89A 1e7bA-3rpkA:
undetectable		 1e7bA-3rpkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Toxoplasma
gondii) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 170
VAL A 219
GLY A 220
ALA A 161
LEU A 157
 None
 0.99A 1e7bA-3sthA:
undetectable		 1e7bA-3sthA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 ILE B  89
PHE B  71
VAL B  81
ALA B 148
LEU B 152
 None
 0.86A 1e7bA-3u0jB:
undetectable		 1e7bA-3u0jB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdy SINGLE-STRANDED
DNA-BINDING PROTEIN
SSBB

(Bacillus
subtilis) 		PF00436
(SSB) 		5 LEU A  11
VAL A 100
GLY A  72
ALA A  97
LEU A  53
 None
 1.13A 1e7bA-3vdyA:
undetectable		 1e7bA-3vdyA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		5 ILE A 239
LEU A 250
VAL A 326
GLY A 325
ALA A 323
 None
 1.15A 1e7bA-3vi1A:
1.0		 1e7bA-3vi1A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 PHE A 253
LEU A 263
VAL A 304
ALA A 300
LEU A 334
 None
 1.15A 1e7bA-3vtrA:
undetectable		 1e7bA-3vtrA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae) 		PF00079
(Serpin) 		5 ILE A 122
LEU A 322
VAL A  42
GLY A  45
LEU A 175
 None
 1.13A 1e7bA-3vvjA:
undetectable		 1e7bA-3vvjA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		5 LEU A  69
VAL A  87
GLY A  90
ALA A  60
LEU A  20
 None
 1.19A 1e7bA-3vzbA:
undetectable		 1e7bA-3vzbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		5 ILE A 244
VAL A 177
GLY A 174
ALA A 253
LEU A 257
 None
 1.15A 1e7bA-3zfvA:
undetectable		 1e7bA-3zfvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bms ALCLOHOL
DEHYDROGENASE/SHORT-
CHAIN DEHYDROGENASE

(Ralstonia sp.
DSMZ 6428) 		PF13561
(adh_short_C2) 		5 LEU A  84
VAL A  36
GLY A  13
ALA A  59
LEU A  70
 None
None
NAP  A1250 (-3.1A)
None
None
 1.17A 1e7bA-4bmsA:
undetectable		 1e7bA-4bmsA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e79 UDP-3-O-ACYLGLUCOSAM
INE
N-ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2) 		5 ILE A  64
VAL A  17
GLY A  19
ALA A  88
LEU A  92
 None
 1.01A 1e7bA-4e79A:
undetectable		 1e7bA-4e79A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e79 UDP-3-O-ACYLGLUCOSAM
INE
N-ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2) 		5 LEU A  10
VAL A  17
GLY A  19
ALA A  88
LEU A  92
 None
 1.10A 1e7bA-4e79A:
undetectable		 1e7bA-4e79A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9b BETA-PHOSPHOGLUCOMUT
ASE

(Escherichia
coli) 		PF13419
(HAD_2) 		5 ILE A 170
LEU A 125
VAL A 112
GLY A 113
LEU A 102
 None
 0.93A 1e7bA-4g9bA:
undetectable		 1e7bA-4g9bA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
NAD-BINDING

(Dyadobacter
fermentans) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 ILE A 262
PHE A 235
GLY A 238
ALA A 179
LEU A 182
 None
 1.14A 1e7bA-4gbjA:
undetectable		 1e7bA-4gbjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu3 OXYGEN SENSOR
PROTEIN DOSP

(Escherichia
coli) 		PF00563
(EAL) 		5 ILE A 719
VAL A 756
GLY A 755
ALA A 753
LEU A 765
 None
 1.07A 1e7bA-4hu3A:
undetectable		 1e7bA-4hu3A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7a ETHANOLAMINE
UTILIZATION PROTEIN
EUTN/CARBOXYSOME
STRUCTURAL PROTEIN
CCML

(Rhodospirillum
rubrum) 		PF03319
(EutN_CcmL) 		5 ILE A  81
LEU A  30
VAL A   6
GLY A  52
ALA A  49
 None
 1.12A 1e7bA-4i7aA:
undetectable		 1e7bA-4i7aA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Brugia malayi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 175
VAL A 222
GLY A 223
ALA A 166
LEU A 162
 None
 1.07A 1e7bA-4k9dA:
undetectable		 1e7bA-4k9dA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		5 ASN A 628
PHE A 555
VAL A 451
GLY A 450
LEU A 625
 None
None
None
None
IOD  A 708 ( 4.7A)
 1.10A 1e7bA-4kcaA:
undetectable		 1e7bA-4kcaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leb AGGLUTININ-LIKE
PROTEIN 3

(Candida
albicans) 		PF11766
(Candida_ALS_N) 		5 ILE A   3
VAL A  97
GLY A  47
ALA A  44
LEU A  39
 None
 1.16A 1e7bA-4lebA:
undetectable		 1e7bA-4lebA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		5 ILE A 240
VAL A 180
GLY A 183
ALA A 204
LEU A 213
 None
PLP  A 403 (-3.9A)
PLP  A 403 (-3.4A)
None
None
 1.15A 1e7bA-4lmbA:
0.6		 1e7bA-4lmbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
cruzi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 174
VAL A 221
GLY A 222
ALA A 165
LEU A 161
 None
 1.00A 1e7bA-4lsmA:
undetectable		 1e7bA-4lsmA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00118
(Cpn60_TCP1) 		5 ILE A  99
LEU A 427
VAL A 124
ALA A 509
LEU A 505
 None
 1.17A 1e7bA-4pj1A:
undetectable		 1e7bA-4pj1A:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 ASN A 391
PHE A 403
LEU A 407
VAL A 433
GLY A 434
LEU A 453
 NPS  A 601 (-4.3A)
None
NPS  A 601 ( 4.9A)
None
None
NPS  A 601 (-4.7A)
 0.41A 1e7bA-4po0A:
46.2		 1e7bA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjk PHOSPHOPANTETHEINYL
TRANSFERASE PPTT

(Mycobacterium
tuberculosis) 		PF01648
(ACPS) 		5 ILE A  73
VAL A 102
GLY A  89
ALA A  59
LEU A  63
 None
 1.03A 1e7bA-4qjkA:
undetectable		 1e7bA-4qjkA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjl PHOSPHOPANTETHEINYL
TRANSFERASE, PPTII

(Mycobacterium
ulcerans) 		PF01648
(ACPS) 		5 ILE A  73
VAL A 102
GLY A  89
ALA A  59
LEU A  63
 None
 0.87A 1e7bA-4qjlA:
undetectable		 1e7bA-4qjlA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		5 ILE A 444
VAL A 473
GLY A 460
ALA A 430
LEU A 434
 None
 0.87A 1e7bA-4qvhA:
undetectable		 1e7bA-4qvhA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1

(Saccharomyces
cerevisiae) 		PF01977
(UbiD) 		5 PHE A  53
VAL A 316
GLY A  68
CYH A  69
LEU A 144
 None
 1.17A 1e7bA-4s13A:
undetectable		 1e7bA-4s13A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 ILE A 884
VAL A 871
GLY A 975
ALA A 873
LEU A 853
 None
 0.94A 1e7bA-4u48A:
undetectable		 1e7bA-4u48A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT

(Mycobacterium
tuberculosis) 		PF01648
(ACPS) 		5 ILE A  73
VAL A 102
GLY A  89
ALA A  59
LEU A  63
 None
 1.02A 1e7bA-4u89A:
undetectable		 1e7bA-4u89A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6g OXYR

(Pseudomonas
aeruginosa) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		5 LEU A 105
VAL A  95
GLY A  96
ALA A 143
LEU A 289
 None
 1.12A 1e7bA-4x6gA:
undetectable		 1e7bA-4x6gA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkz VALINE-TRNA LIGASE

(Pseudomonas
aeruginosa) 		PF08264
(Anticodon_1) 		5 LEU A 825
VAL A 806
GLY A 805
ALA A 847
LEU A 849
 None
 1.03A 1e7bA-4xkzA:
undetectable		 1e7bA-4xkzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0m OXYR

(Pseudomonas
aeruginosa) 		PF03466
(LysR_substrate) 		5 LEU A 105
VAL A  95
GLY A  96
ALA A 143
LEU A 289
 None
 1.14A 1e7bA-4y0mA:
undetectable		 1e7bA-4y0mA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ILE A 161
LEU A 250
VAL A 247
GLY A 203
ALA A 103
 None
 1.09A 1e7bA-5bp1A:
undetectable		 1e7bA-5bp1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3) 		5 LEU A 185
VAL A  25
GLY A  24
ALA B  74
LEU B  75
 None
 1.14A 1e7bA-5c5bA:
undetectable		 1e7bA-5c5bA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 ILE A 229
PHE A 102
LEU A 149
GLY A 346
ALA A 233
 HEM  A 403 (-4.7A)
HEM  A 403 (-4.6A)
None
HEM  A 403 (-3.6A)
DAO  A 402 (-3.6A)
 1.04A 1e7bA-5cweA:
undetectable		 1e7bA-5cweA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da8 60 KDA CHAPERONIN

(Chlorobaculum
tepidum) 		PF00118
(Cpn60_TCP1) 		5 ILE A  99
LEU A 426
VAL A 124
ALA A 509
LEU A 505
 None
 1.10A 1e7bA-5da8A:
undetectable		 1e7bA-5da8A:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		6 ASN A 390
PHE A 402
LEU A 406
VAL A 432
GLY A 433
LEU A 452
 None
 0.70A 1e7bA-5dqfA:
46.6		 1e7bA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis) 		PF00067
(p450) 		5 ILE A 217
LEU A 343
VAL A 225
GLY A  83
LEU A 205
 None
HEM  A 401 ( 4.0A)
None
None
None
 1.10A 1e7bA-5ex8A:
3.3		 1e7bA-5ex8A:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		7 ASN A 391
PHE A 403
LEU A 407
VAL A 433
GLY A 434
ALA A 449
LEU A 453
 None
 0.52A 1e7bA-5ghkA:
45.3		 1e7bA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 ILE A 740
VAL A 704
GLY A 705
ALA A 744
LEU A 748
 None
 1.01A 1e7bA-5hm5A:
undetectable		 1e7bA-5hm5A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		5 LEU A 302
VAL A 363
GLY A 364
ALA A 425
LEU A 426
 None
 0.99A 1e7bA-5hxaA:
undetectable		 1e7bA-5hxaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		5 ILE A 100
LEU A 222
CYH A 136
ALA A 132
LEU A 156
 None
 0.94A 1e7bA-5jrjA:
undetectable		 1e7bA-5jrjA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1t MUCR
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 ILE A 612
VAL A 649
GLY A 648
ALA A 646
LEU A 658
 None
None
C2E  A 701 (-3.6A)
None
None
 1.06A 1e7bA-5m1tA:
undetectable		 1e7bA-5m1tA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN

(Tick-borne
encephalitis
virus) 		no annotation 5 ILE A 137
LEU A  45
VAL A 192
GLY A 191
LEU A 283
 None
 1.18A 1e7bA-5o6vA:
undetectable		 1e7bA-5o6vA:
8.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 6 ILE A 387
ASN A 390
LEU A 406
VAL A 432
GLY A 433
LEU A 452
 None
 0.64A 1e7bA-5oriA:
45.9		 1e7bA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 6 ILE A 387
ASN A 390
PHE A 402
LEU A 406
GLY A 433
LEU A 452
 None
 0.66A 1e7bA-5oriA:
45.9		 1e7bA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Naegleria
gruberi) 		no annotation 5 ILE A 167
VAL A 214
GLY A 215
ALA A 158
LEU A 154
 None
 0.96A 1e7bA-5ur0A:
undetectable		 1e7bA-5ur0A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 ASN A 391
LEU A 407
VAL A 433
GLY A 434
ALA A 449
LEU A 453
 None
 0.47A 1e7bA-5yxeA:
47.6		 1e7bA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 ASN A 391
PHE A 403
LEU A 407
GLY A 434
ALA A 449
LEU A 453
 None
 0.46A 1e7bA-5yxeA:
47.6		 1e7bA-5yxeA:
11.11