SIMILAR PATTERNS OF AMINO ACIDS FOR 1E7B_A_HLTA4002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 ARG A  55
ALA A  56
ALA A 274
GLU A 277
 None
 1.16A 1e7bA-1bjwA:
0.0		 1e7bA-1bjwA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ARG A 309
ALA A 308
ALA A 290
GLU A 302
 None
 1.23A 1e7bA-1dmsA:
undetectable		 1e7bA-1dmsA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dof ADENYLOSUCCINATE
LYASE

(Pyrobaculum
aerophilum) 		PF00206
(Lyase_1) 		4 ARG A 131
ALA A 127
ALA A 397
GLU A 395
 None
 1.23A 1e7bA-1dofA:
2.9		 1e7bA-1dofA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00106
(adh_short) 		4 ARG A 252
ALA A 197
ALA A 157
GLU A 160
 None
 0.94A 1e7bA-1e6wA:
0.4		 1e7bA-1e6wA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 ARG A 271
ALA A 267
ALA A 230
GLU A 226
 None
 1.15A 1e7bA-1fuiA:
1.6		 1e7bA-1fuiA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 ARG A  13
ALA A 227
ALA A 331
GLU A 329
 None
 1.13A 1e7bA-1guqA:
0.0		 1e7bA-1guqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 ARG A  13
ALA A 227
ALA A 332
GLU A 329
 None
 1.13A 1e7bA-1guqA:
0.0		 1e7bA-1guqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6r METHIONINE SYNTHASE

(Thermotoga
maritima) 		no annotation 4 ARG A  42
ALA A  43
ALA A 115
GLU A 111
 None
 1.22A 1e7bA-1j6rA:
undetectable		 1e7bA-1j6rA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		4 ARG A 183
ALA A 182
ALA A 219
GLU A 221
 None
 1.10A 1e7bA-1ktnA:
undetectable		 1e7bA-1ktnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no7 MAJOR CAPSID PROTEIN

(Human
alphaherpesvirus
1) 		PF03122
(Herpes_MCP) 		4 ARG A 660
ALA A 613
ALA A 688
GLU A 685
 None
 1.10A 1e7bA-1no7A:
0.0		 1e7bA-1no7A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5e SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF09272
(Hepsin-SRCR) 		4 ARG L  39
ALA L  38
ALA L  53
GLU L  46
 None
 1.08A 1e7bA-1o5eL:
undetectable		 1e7bA-1o5eL:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE

(Enterococcus
faecium) 		PF01427
(Peptidase_M15) 		4 ARG A 147
ALA A 152
ALA A 160
GLU A 159
 None
 0.99A 1e7bA-1r44A:
undetectable		 1e7bA-1r44A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		4 ARG A 100
ALA A  58
ALA A 126
GLU A 128
 None
 0.93A 1e7bA-1t9kA:
undetectable		 1e7bA-1t9kA:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 ARG A 209
ALA A 213
ALA A 350
GLU A 354
 DKA  A1001 ( 4.6A)
DKA  A1001 ( 4.0A)
DKA  A1002 ( 3.8A)
DKA  A1002 ( 4.4A)
 0.35A 1e7bA-1tf0A:
47.7		 1e7bA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5v CITE

(Mycobacterium
tuberculosis) 		PF03328
(HpcH_HpaI) 		4 ARG A 149
ALA A 136
ALA A 180
GLU A 194
 None
 1.17A 1e7bA-1u5vA:
undetectable		 1e7bA-1u5vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		4 ARG A 232
ALA A 177
ALA A 137
GLU A 140
 None
 0.98A 1e7bA-1uayA:
undetectable		 1e7bA-1uayA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 ARG A 176
ALA A 177
ALA A 139
GLU A 140
 None
 1.07A 1e7bA-1ub3A:
undetectable		 1e7bA-1ub3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 ARG A 176
ALA A 177
ALA A 142
GLU A 140
 None
 1.15A 1e7bA-1ub3A:
undetectable		 1e7bA-1ub3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ARG A 186
ALA A 189
ALA A 213
GLU A 215
 None
KCX  A 188 ( 3.7A)
None
None
 1.22A 1e7bA-1w78A:
undetectable		 1e7bA-1w78A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxd SHIKIMATE
5-DEHYDROGENASE

(Thermus
thermophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ARG A 129
ALA A 124
ALA A 154
GLU A 158
 None
 1.25A 1e7bA-1wxdA:
undetectable		 1e7bA-1wxdA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxd SHIKIMATE
5-DEHYDROGENASE

(Thermus
thermophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ARG A 129
ALA A 124
ALA A 156
GLU A 158
 None
 1.09A 1e7bA-1wxdA:
undetectable		 1e7bA-1wxdA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfk FORMIMIDOYLGLUTAMASE

(Vibrio cholerae) 		PF00491
(Arginase) 		4 ARG A  58
ALA A  54
ALA A 103
GLU A 101
 None
 0.92A 1e7bA-1xfkA:
undetectable		 1e7bA-1xfkA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 ARG A 151
ALA A 150
ALA A   7
GLU A   5
 None
 0.64A 1e7bA-1yirA:
undetectable		 1e7bA-1yirA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		4 ARG A  20
ALA A  19
ALA A  49
GLU A  51
 PO4  A2001 (-4.2A)
None
None
None
 1.13A 1e7bA-1yyaA:
undetectable		 1e7bA-1yyaA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ARG A 290
ALA A 289
ALA A 333
GLU A 335
 None
 1.20A 1e7bA-1zfjA:
undetectable		 1e7bA-1zfjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ARG A  57
ALA A  58
ALA A  18
GLU A  15
 None
 1.12A 1e7bA-2elcA:
undetectable		 1e7bA-2elcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hbo HYPOTHETICAL PROTEIN
(NP_422103.1)

(Caulobacter
vibrioides) 		PF03061
(4HBT) 		4 ARG A 144
ALA A 143
ALA A 152
GLU A 150
 None
 1.12A 1e7bA-2hboA:
undetectable		 1e7bA-2hboA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ARG A 783
ALA A 755
ALA A 762
GLU A 761
 None
 1.16A 1e7bA-2hpiA:
undetectable		 1e7bA-2hpiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idx COB(I)YRINIC ACID
A,C-DIAMIDE
ADENOSYLTRANSFERASE

(Homo sapiens) 		PF01923
(Cob_adeno_trans) 		4 ARG A 191
ALA A 187
ALA A  95
GLU A  91
 None
 1.06A 1e7bA-2idxA:
undetectable		 1e7bA-2idxA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jah CLAVULANIC ACID
DEHYDROGENASE

(Streptomyces
clavuligerus) 		PF00106
(adh_short) 		4 ARG A  25
ALA A  28
ALA A  54
GLU A  50
 None
 1.24A 1e7bA-2jahA:
undetectable		 1e7bA-2jahA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kcv TETRATRICOPEPTIDE
REPEAT DOMAIN
PROTEIN

(Salinibacter
ruber) 		PF14559
(TPR_19) 		4 ARG A   9
ALA A  13
ALA A  27
GLU A  31
 None
 1.22A 1e7bA-2kcvA:
undetectable		 1e7bA-2kcvA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mxy HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEINS
C1/C2

(Homo sapiens) 		PF00076
(RRM_1) 		4 ARG A  64
ALA A  63
ALA A  85
GLU A  87
 None
None
U  B   4 ( 3.5A)
None
 0.97A 1e7bA-2mxyA:
undetectable		 1e7bA-2mxyA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		4 ARG A  20
ALA A  19
ALA A  43
GLU A  45
 None
 1.22A 1e7bA-2nwqA:
undetectable		 1e7bA-2nwqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6c AQ_2013 PROTEIN

(Aquifex
aeolicus) 		PF01894
(UPF0047) 		4 ARG A  16
ALA A  89
ALA A  71
GLU A  68
 None
 1.23A 1e7bA-2p6cA:
undetectable		 1e7bA-2p6cA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ARG G1590
ALA G1655
ALA G1598
GLU G1594
 None
 1.15A 1e7bA-2uv8G:
undetectable		 1e7bA-2uv8G:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A 326
ALA A 328
ALA A 291
GLU A 292
 None
 1.09A 1e7bA-2wbiA:
undetectable		 1e7bA-2wbiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrr AMINOTRANSFERASE,
CLASS V

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		4 ARG A 204
ALA A 199
ALA A  55
GLU A 225
 None
 1.16A 1e7bA-2yrrA:
undetectable		 1e7bA-2yrrA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 ARG A 456
ALA A 480
ALA A 353
GLU A 355
 None
 1.20A 1e7bA-2zpaA:
undetectable		 1e7bA-2zpaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak4 NADH-DEPENDENT
QUINUCLIDINONE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		4 ARG A 205
ALA A 202
ALA A 211
GLU A 215
 None
 1.14A 1e7bA-3ak4A:
undetectable		 1e7bA-3ak4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2

(Burkholderia
pseudomallei) 		PF00464
(SHMT) 		4 ARG A 409
ALA A 405
ALA A 395
GLU A 391
 None
 1.23A 1e7bA-3ecdA:
undetectable		 1e7bA-3ecdA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		4 ARG A  20
ALA A  23
ALA A 221
GLU A 218
 None
 1.12A 1e7bA-3edmA:
undetectable		 1e7bA-3edmA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h75 PERIPLASMIC
SUGAR-BINDING DOMAIN
PROTEIN

(Pseudomonas
protegens) 		PF13407
(Peripla_BP_4) 		4 ARG A 225
ALA A 253
ALA A 285
GLU A 281
 None
 1.16A 1e7bA-3h75A:
undetectable		 1e7bA-3h75A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h90 FERROUS-IRON EFFLUX
PUMP FIEF

(Escherichia
coli) 		PF01545
(Cation_efflux)
PF16916
(ZT_dimer) 		4 ARG A 148
ALA A 149
ALA A 201
GLU A 200
 None
 0.99A 1e7bA-3h90A:
2.0		 1e7bA-3h90A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 ARG A  87
ALA A  86
ALA A 114
GLU A 116
 None
 1.12A 1e7bA-3i09A:
undetectable		 1e7bA-3i09A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 147
ALA A 143
ALA A 195
GLU A 191
 None
 1.25A 1e7bA-3i4gA:
undetectable		 1e7bA-3i4gA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 ARG B 946
ALA B 769
ALA B 823
GLU B 786
 None
 1.03A 1e7bA-3o8oB:
undetectable		 1e7bA-3o8oB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9x PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Bacillus
halodurans) 		PF00551
(Formyl_trans_N) 		4 ARG A 176
ALA A 180
ALA A 151
GLU A 153
 SO4  A 214 (-4.4A)
None
None
None
 0.92A 1e7bA-3p9xA:
undetectable		 1e7bA-3p9xA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 ARG A 249
ALA A 194
ALA A 154
GLU A 157
 None
 0.94A 1e7bA-3ppiA:
undetectable		 1e7bA-3ppiA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Staphylococcus
aureus) 		PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11) 		4 ARG A 255
ALA A 158
ALA A 274
GLU A 270
 None
 1.19A 1e7bA-3rkxA:
undetectable		 1e7bA-3rkxA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		4 ARG A 451
ALA A 449
ALA A 435
GLU A  26
 None
 0.95A 1e7bA-3sfwA:
undetectable		 1e7bA-3sfwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 ARG A 341
ALA A 345
ALA A 357
GLU A 361
 None
 1.15A 1e7bA-3tqoA:
undetectable		 1e7bA-3tqoA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ARG A 413
ALA A 414
ALA A 344
GLU A 348
 None
 1.12A 1e7bA-3ue3A:
undetectable		 1e7bA-3ue3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v57 PHYCOERYTHRIN BETA
SUBUNIT

(Porphyridium
purpureum) 		PF00502
(Phycobilisome) 		4 ARG B  37
ALA B  40
ALA B 162
GLU B 164
 None
PEB  B 204 ( 4.0A)
None
None
 1.18A 1e7bA-3v57B:
undetectable		 1e7bA-3v57B:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA

(Streptomyces
lividans) 		PF00266
(Aminotran_5) 		4 ARG A  49
ALA A  53
ALA A 209
GLU A 235
 None
 1.21A 1e7bA-3vaxA:
undetectable		 1e7bA-3vaxA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 ARG A 344
ALA A 345
ALA A 330
GLU A 295
 None
 0.83A 1e7bA-4dykA:
undetectable		 1e7bA-4dykA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		4 ARG A 153
ALA A 154
ALA A 258
GLU A 263
 None
 1.11A 1e7bA-4glfA:
undetectable		 1e7bA-4glfA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gsl AUTOPHAGY-RELATED
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF03986
(Autophagy_N)
PF03987
(Autophagy_act_C)
PF10381
(Autophagy_C) 		4 ARG C 167
ALA C  76
ALA C  80
GLU C 203
 None
 1.12A 1e7bA-4gslC:
undetectable		 1e7bA-4gslC:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iit PHENYLACETATE-COA
OXYGENASE SUBUNIT
PAAB
PHENYLACETATE-COA
OXYGENASE SUBUNIT
PAAC

(Klebsiella
pneumoniae) 		PF05138
(PaaA_PaaC)
PF06243
(PaaB) 		4 ARG C 146
ALA B  30
ALA B  35
GLU B  37
 None
 0.95A 1e7bA-4iitC:
undetectable		 1e7bA-4iitC:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 119
ALA A 121
ALA A 128
GLU A 130
 None
 1.05A 1e7bA-4izgA:
undetectable		 1e7bA-4izgA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ARG A 244
ALA A 305
ALA A 379
GLU A 381
 None
 1.00A 1e7bA-4lbwA:
undetectable		 1e7bA-4lbwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		4 ARG A 255
ALA A 211
ALA A 263
GLU A 262
 None
 1.16A 1e7bA-4llsA:
undetectable		 1e7bA-4llsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE

(Staphylococcus
aureus) 		PF02423
(OCD_Mu_crystall) 		4 ARG A  10
ALA A 115
ALA A  95
GLU A  93
 None
 1.11A 1e7bA-4mp3A:
undetectable		 1e7bA-4mp3A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Archaeoglobus
fulgidus) 		PF00215
(OMPdecase) 		4 ARG A  92
ALA A  91
ALA A 120
GLU A 122
 None
 1.08A 1e7bA-4muzA:
undetectable		 1e7bA-4muzA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A 270
ALA A 316
ALA A  77
GLU A  96
 None
 1.21A 1e7bA-4mv3A:
undetectable		 1e7bA-4mv3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B

(Streptococcus
thermophilus) 		PF02421
(FeoB_N) 		4 ARG A 197
ALA A 200
ALA A 179
GLU A 177
 ARG  A 197 ( 0.6A)
ALA  A 200 ( 0.0A)
ALA  A 179 ( 0.0A)
GLU  A 177 ( 0.6A)
 0.96A 1e7bA-4nonA:
undetectable		 1e7bA-4nonA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella suis) 		PF13561
(adh_short_C2) 		4 ARG A  22
ALA A  21
ALA A  44
GLU A  46
 None
 1.20A 1e7bA-4o6vA:
undetectable		 1e7bA-4o6vA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		4 ARG A 267
ALA A 271
ALA A  58
GLU A  62
 None
 1.08A 1e7bA-4oanA:
undetectable		 1e7bA-4oanA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 ARG A 413
ALA A  79
ALA A 147
GLU A 143
 None
 1.18A 1e7bA-4qjyA:
undetectable		 1e7bA-4qjyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A 853
ALA A1041
ALA A1012
GLU A1010
 None
 1.18A 1e7bA-4rcnA:
undetectable		 1e7bA-4rcnA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm7 ACYL-COA
DEHYDROGENASE

(Slackia
heliotrinireducens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A 304
ALA A 303
ALA A  69
GLU A   9
 None
 1.18A 1e7bA-4rm7A:
undetectable		 1e7bA-4rm7A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ARG A  32
ALA A 187
ALA A  38
GLU A 117
 None
 1.13A 1e7bA-4u8hA:
undetectable		 1e7bA-4u8hA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 ARG A 109
ALA A 105
ALA A 141
GLU A 145
 None
 0.97A 1e7bA-4v1yA:
undetectable		 1e7bA-4v1yA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0a SHIKIMATE KINASE

(Acinetobacter
baumannii) 		PF01202
(SKI) 		4 ARG A 173
ALA A 176
ALA A  39
GLU A  40
 None
 1.07A 1e7bA-4y0aA:
undetectable		 1e7bA-4y0aA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt9 PEPTIDYLARGININE
DEIMINASE

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		4 ARG A  56
ALA A 136
ALA A 357
GLU A  62
 GOL  A 505 (-4.9A)
None
None
None
 1.23A 1e7bA-4yt9A:
1.8		 1e7bA-4yt9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5er7 GAP JUNCTION BETA-2
PROTEIN

(Homo sapiens) 		no annotation 4 ARG B  75
ALA B  78
ALA B  40
GLU B  47
 None
None
None
CA  B 301 (-2.3A)
 1.10A 1e7bA-5er7B:
undetectable		 1e7bA-5er7B:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ARG B 229
ALA C 598
ALA B 312
GLU B 313
 None
 1.26A 1e7bA-5g5gB:
undetectable		 1e7bA-5g5gB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		4 ARG A 296
ALA A 299
ALA A 163
GLU A 169
 None
 0.91A 1e7bA-5ghsA:
undetectable		 1e7bA-5ghsA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6o PORPHOBILINOGEN
DEAMINASE

(Vibrio cholerae) 		no annotation 4 ARG A  17
ALA A  15
ALA A  75
GLU A  71
 None
 1.26A 1e7bA-5h6oA:
undetectable		 1e7bA-5h6oA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 ARG A 292
ALA A 290
ALA A 117
GLU A 115
 None
 1.08A 1e7bA-5i5lA:
undetectable		 1e7bA-5i5lA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdq CHITOPORIN

(Vibrio harveyi) 		no annotation 4 ARG A 330
ALA A 211
ALA A 246
GLU A 252
 None
 0.93A 1e7bA-5mdqA:
undetectable		 1e7bA-5mdqA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4

(Human
alphaherpesvirus
1) 		PF03584
(Herpes_ICP4_N) 		4 ARG A 336
ALA A 406
ALA A 345
GLU A 365
 None
 1.22A 1e7bA-5mhjA:
undetectable		 1e7bA-5mhjA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhk RS1

(Human
alphaherpesvirus
1) 		PF03584
(Herpes_ICP4_N) 		4 ARG A 336
ALA A 406
ALA A 345
GLU A 365
 None
 1.23A 1e7bA-5mhkA:
undetectable		 1e7bA-5mhkA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL

(Homo sapiens) 		PF01180
(DHO_dh) 		4 ARG A  57
ALA A  59
ALA A 104
GLU A 103
 None
U91  A 403 (-3.3A)
None
None
 1.11A 1e7bA-5mvdA:
undetectable		 1e7bA-5mvdA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o30 PUTATIVE
OXIDOREDUCTASE

(Ilumatobacter
coccineus) 		PF13561
(adh_short_C2) 		4 ARG A  25
ALA A  24
ALA A  15
GLU A  50
 None
 1.10A 1e7bA-5o30A:
undetectable		 1e7bA-5o30A:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 4 ARG A 208
ALA A 212
ALA A 349
GLU A 353
 None
 0.25A 1e7bA-5oriA:
45.9		 1e7bA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv6 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 3

(Methylophaga
aminisulfidivorans) 		PF00497
(SBP_bac_3) 		4 ARG A  70
ALA A  65
ALA A 261
GLU A 257
 None
 1.19A 1e7bA-5sv6A:
undetectable		 1e7bA-5sv6A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjj TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY

(Alicyclobacillus
acidocaldarius) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 ARG A 145
ALA A 191
ALA A 203
GLU A 196
 None
 1.24A 1e7bA-5tjjA:
undetectable		 1e7bA-5tjjA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		4 ARG A 288
ALA A 287
ALA A 331
GLU A 333
 None
 1.15A 1e7bA-5upyA:
undetectable		 1e7bA-5upyA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ARG A 102
ALA A 103
ALA A 290
GLU A 289
 None
 1.04A 1e7bA-5w4xA:
undetectable		 1e7bA-5w4xA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w75 ELONGATION FACTOR TU

(Thermotoga
neapolitana) 		no annotation 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 1.05A 1e7bA-5w75A:
0.9		 1e7bA-5w75A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 0.99A 1e7bA-5w76A:
1.6		 1e7bA-5w76A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 0.94A 1e7bA-5w7qA:
1.5		 1e7bA-5w7qA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 4 ARG A 265
ALA A 264
ALA A  18
GLU A  15
 None
 0.94A 1e7bA-5wabA:
undetectable		 1e7bA-5wabA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk0 DAMAGE-INDUCIBLE
PROTEIN DINB

(Staphylococcus
sp. HMSC055H04) 		no annotation 4 ARG A 102
ALA A 103
ALA A  55
GLU A  53
 None
 1.19A 1e7bA-5wk0A:
undetectable		 1e7bA-5wk0A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 ARG A 295
ALA A 298
ALA A 162
GLU A 168
 None
 0.93A 1e7bA-5x4jA:
undetectable		 1e7bA-5x4jA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 4 ARG A 209
ALA A 213
ALA A 350
GLU A 354
 None
 0.55A 1e7bA-5yxeA:
47.6		 1e7bA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6m CYANATE HYDRATASE

(Serratia
proteamaculans) 		no annotation 4 ARG A  59
ALA A  58
ALA A  71
GLU A  69
 None
 1.06A 1e7bA-6b6mA:
undetectable		 1e7bA-6b6mA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 4 ARG A 700
ALA A 699
ALA A 681
GLU A 686
 None
 0.97A 1e7bA-6bfiA:
undetectable		 1e7bA-6bfiA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gqd GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Homo sapiens) 		no annotation 4 ARG A  33
ALA A 247
ALA A 354
GLU A 352
 None
 1.12A 1e7bA-6gqdA:
undetectable		 1e7bA-6gqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9rub RIBULOSE-1,5-BISPHOS
PHATE CARBOXYLASE

(Rhodospirillum
rubrum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 217
ALA A 218
ALA A 182
GLU A 178
 None
 1.14A 1e7bA-9rubA:
undetectable		 1e7bA-9rubA:
21.99