SIMILAR PATTERNS OF AMINO ACIDS FOR 1E7B_A_HLTA4001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		4 LYS A 219
ALA A 218
ASP A 377
GLY A 339
 3PG  A 423 ( 2.6A)
ADP  A 421 (-3.4A)
MG  A 422 ( 3.4A)
ADP  A 421 ( 4.1A)
 0.97A 1e7bA-13pkA:
0.0		 1e7bA-13pkA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 ARG A 279
ALA A  51
ASP A 146
GLY A 150
 None
 1.09A 1e7bA-1bt2A:
0.1		 1e7bA-1bt2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		4 ARG A 288
ALA A 285
ASP A 265
GLY A 263
 None
 1.02A 1e7bA-1dabA:
undetectable		 1e7bA-1dabA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		4 LYS A 187
ALA A 188
ASP A 126
GLY A 124
 None
None
MAN  A 329 ( 4.9A)
None
 1.21A 1e7bA-1g0vA:
undetectable		 1e7bA-1g0vA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gu3 ENDOGLUCANASE C

(Cellulomonas
fimi) 		PF02018
(CBM_4_9) 		4 ARG A  75
ALA A 126
ASP A  90
GLY A  79
 BGC  A 601 (-3.0A)
BGC  A 602 ( 4.5A)
None
None
 0.90A 1e7bA-1gu3A:
undetectable		 1e7bA-1gu3A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyo LIGHT CHAIN (VL) OF
FV-FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 ARG K  24
ALA K  25
ASP K  70
GLY K  68
 None
 0.98A 1e7bA-1kyoK:
undetectable		 1e7bA-1kyoK:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5q SMALL NUCLEAR
RIBONUCLEOPROTEIN
HOMOLOG

(Pyrobaculum
aerophilum) 		no annotation 4 ARG A  83
LYS A  87
ALA A  86
ASP A  81
 None
 1.05A 1e7bA-1m5qA:
undetectable		 1e7bA-1m5qA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qag UTROPHIN ACTIN
BINDING REGION

(Homo sapiens) 		PF00307
(CH) 		4 ARG A  86
ALA A  89
ASP A 117
GLY A 112
 None
 1.19A 1e7bA-1qagA:
undetectable		 1e7bA-1qagA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwr FILAMENTOUS
HEMAGGLUTININ

(Bordetella
pertussis) 		PF05860
(Haemagg_act) 		4 ARG A 242
ALA A 262
ASP A 218
GLY A 240
 None
 0.95A 1e7bA-1rwrA:
undetectable		 1e7bA-1rwrA:
18.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 ARG A 209
LYS A 212
ALA A 213
ASP A 324
GLY A 328
 DKA  A1001 ( 4.6A)
None
DKA  A1001 ( 4.0A)
DKA  A1001 (-4.7A)
DKA  A1001 ( 4.1A)
 0.66A 1e7bA-1tf0A:
47.7		 1e7bA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E

(Bacillus cereus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ARG A 419
ALA A 418
ASP A 385
GLY A 414
 None
 1.16A 1e7bA-1uokA:
undetectable		 1e7bA-1uokA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Escherichia
coli) 		PF00581
(Rhodanese) 		4 ARG A 178
ALA A 181
ASP A 184
GLY A 193
 None
 1.13A 1e7bA-1urhA:
0.0		 1e7bA-1urhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		4 ARG A 118
ALA A 117
ASP A 120
GLY A 122
 None
 0.98A 1e7bA-1us4A:
undetectable		 1e7bA-1us4A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ARG A 162
ALA A 165
ASP A 172
GLY A 170
 None
 1.19A 1e7bA-1v5vA:
undetectable		 1e7bA-1v5vA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aip PROTEIN C ACTIVATOR

(Agkistrodon
contortrix) 		PF00089
(Trypsin) 		4 ARG A  95
ALA A 177
ASP A  96
GLY A 175
 None
 0.91A 1e7bA-2aipA:
undetectable		 1e7bA-2aipA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		4 ARG A  18
LYS A  53
ALA A  54
ASP A  12
 None
 1.14A 1e7bA-2cevA:
0.0		 1e7bA-2cevA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF01255
(Prenyltransf) 		4 ARG A  26
LYS A  20
ALA A  19
GLY A  14
 None
 1.08A 1e7bA-2d2rA:
undetectable		 1e7bA-2d2rA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		4 ARG A 297
ALA A 295
ASP A 325
GLY A 174
 None
 0.94A 1e7bA-2epgA:
undetectable		 1e7bA-2epgA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ARG A 372
ALA A 347
ASP A 401
GLY A 344
 None
 0.97A 1e7bA-2f3oA:
undetectable		 1e7bA-2f3oA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		4 ARG A  78
ALA A  84
ASP A  96
GLY A  17
 None
 1.02A 1e7bA-2fukA:
0.5		 1e7bA-2fukA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		4 ARG A  89
ALA A  88
ASP A  91
GLY A  65
 None
 0.89A 1e7bA-2ghpA:
undetectable		 1e7bA-2ghpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		4 ARG G 320
ALA G 317
ASP G 297
GLY G 295
 None
 1.04A 1e7bA-2iouG:
undetectable		 1e7bA-2iouG:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 ARG A 252
ALA A 273
ASP A 254
GLY A 275
 None
 0.97A 1e7bA-2j0jA:
undetectable		 1e7bA-2j0jA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7p CELL DIVISION
PROTEIN FTSY

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ARG D 124
ALA D 120
ASP D 287
GLY D 285
 None
 1.04A 1e7bA-2j7pD:
undetectable		 1e7bA-2j7pD:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0n HYPOTHETICAL PROTEIN
NMB1532

(Neisseria
meningitidis) 		PF01814
(Hemerythrin) 		4 ARG A 166
ALA A 165
ASP A  69
GLY A 160
 None
 1.04A 1e7bA-2p0nA:
undetectable		 1e7bA-2p0nA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 ARG A 277
ALA A  50
ASP A 145
GLY A 149
 None
 1.15A 1e7bA-2p3xA:
undetectable		 1e7bA-2p3xA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q47 PROBABLE
TYROSINE-PROTEIN
PHOSPHATASE
AT1G05000

(Arabidopsis
thaliana) 		PF03162
(Y_phosphatase2) 		4 ARG A 188
ALA A 183
ASP A 191
GLY A 158
 SO4  A 203 ( 4.2A)
None
None
None
 1.15A 1e7bA-2q47A:
undetectable		 1e7bA-2q47A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtv SMALL COPII COAT
GTPASE SAR1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 ARG B 105
ALA B 109
ASP B  32
GLY B  30
 None
 1.19A 1e7bA-2qtvB:
undetectable		 1e7bA-2qtvB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1q HYALURONOGLUCOSAMINI
DASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 ARG A 865
ALA A 942
ASP A 831
GLY A 829
 None
 1.14A 1e7bA-2w1qA:
undetectable		 1e7bA-2w1qA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ARG A  49
ALA A  19
ASP A  51
GLY A  17
 None
 0.98A 1e7bA-2wtbA:
undetectable		 1e7bA-2wtbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xlr FLAVIN-CONTAINING
MONOOXYGENASE

(Methylophaga
aminisulfidivorans) 		PF00743
(FMO-like) 		4 ARG A 115
LYS A 118
ALA A 119
ASP A  88
 None
 1.07A 1e7bA-2xlrA:
undetectable		 1e7bA-2xlrA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 LYS A 121
ALA A 123
ASP A  93
GLY A  95
 None
 0.92A 1e7bA-2yv2A:
undetectable		 1e7bA-2yv2A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq2 6B PROTEIN

(Agrobacterium
vitis) 		PF02027
(RolB_RolC) 		4 ARG A  12
ALA A  72
ASP A  10
GLY A  76
 None
 1.03A 1e7bA-3aq2A:
undetectable		 1e7bA-3aq2A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A  63
ALA A   8
ASP A  65
GLY A   6
 None
 1.05A 1e7bA-3db2A:
undetectable		 1e7bA-3db2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Glutamicibacter
protophormiae) 		PF03644
(Glyco_hydro_85) 		4 ARG A 223
ALA A 215
ASP A 210
GLY A 212
 None
 0.71A 1e7bA-3fhaA:
undetectable		 1e7bA-3fhaA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC4

(Schizosaccharomyces
pombe) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF03604
(DNA_RNApol_7kD) 		4 ARG L  63
LYS C 170
ASP C  46
GLY C 163
 None
 0.93A 1e7bA-3h0gL:
undetectable		 1e7bA-3h0gL:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE

(Trypanosoma
brucei) 		no annotation 4 ARG A  17
ALA A 158
ASP A 237
GLY A 241
 None
 1.13A 1e7bA-3hj4A:
undetectable		 1e7bA-3hj4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LYS A 109
ALA A 108
ASP A  88
GLY A  91
 None
 1.15A 1e7bA-3hskA:
undetectable		 1e7bA-3hskA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4

(Thermus
thermophilus) 		PF00346
(Complex1_49kDa) 		4 ARG 4 249
ALA 4 349
ASP 4 247
GLY 4 237
 None
 1.05A 1e7bA-3i9v4:
undetectable		 1e7bA-3i9v4:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilh TWO COMPONENT
RESPONSE REGULATOR

(Cytophaga
hutchinsonii) 		PF00072
(Response_reg) 		4 ARG A 103
LYS A 107
ALA A 106
ASP A 101
 None
 1.18A 1e7bA-3ilhA:
undetectable		 1e7bA-3ilhA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens;
synthetic
construct) 		PF00025
(Arf)
PF01412
(ArfGap)
PF12796
(Ank_2) 		4 ARG E  95
ALA E  99
ASP E  22
GLY E  20
 None
None
CA  E 739 (-4.9A)
None
 1.10A 1e7bA-3lvrE:
undetectable		 1e7bA-3lvrE:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1q DESERT HEDGEHOG
PROTEIN

(Homo sapiens) 		no annotation 4 ARG B 102
ALA B 188
ASP B 172
GLY B  61
 None
 1.12A 1e7bA-3n1qB:
undetectable		 1e7bA-3n1qB:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 ARG A 867
LYS A 871
ALA A 868
GLY A 472
 None
 0.91A 1e7bA-3ne5A:
undetectable		 1e7bA-3ne5A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A  63
LYS A  62
ALA A  64
GLY A  70
 None
 1.15A 1e7bA-3ozyA:
undetectable		 1e7bA-3ozyA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 ARG B 177
ALA B 176
ASP B 168
GLY B 171
 None
 1.13A 1e7bA-3pcoB:
undetectable		 1e7bA-3pcoB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1v PROBABLE
TRANSALDOLASE

(Thermoplasma
acidophilum) 		PF00923
(TAL_FSA) 		4 ARG A  74
LYS A  75
ALA A  73
GLY A  68
 None
 0.97A 1e7bA-3s1vA:
undetectable		 1e7bA-3s1vA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		4 ARG A 344
ALA A 345
ASP A 335
GLY A 342
 None
 1.03A 1e7bA-3t8lA:
undetectable		 1e7bA-3t8lA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tjz ADP-RIBOSYLATION
FACTOR 1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 ARG A  99
ALA A 103
ASP A  26
GLY A  24
 None
 1.15A 1e7bA-3tjzA:
undetectable		 1e7bA-3tjzA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 ARG A1681
ALA A1739
ASP A1690
GLY A1688
 None
 1.17A 1e7bA-3topA:
undetectable		 1e7bA-3topA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ARG A 405
ALA A 404
ASP A 372
GLY A 400
 None
 1.18A 1e7bA-4aieA:
undetectable		 1e7bA-4aieA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh6 APC/C ACTIVATOR
PROTEIN CDH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ARG A 362
ALA A 348
ASP A 345
GLY A 324
 None
 1.03A 1e7bA-4bh6A:
undetectable		 1e7bA-4bh6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SAR1P

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 ARG B 105
ALA B 109
ASP B  32
GLY B  30
 None
 1.19A 1e7bA-4bziB:
undetectable		 1e7bA-4bziB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dag FUSION GLYCOPROTEIN
F0

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		4 ARG A 304
ALA A 288
ASP A 306
GLY A 308
 None
 1.19A 1e7bA-4dagA:
undetectable		 1e7bA-4dagA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di1 ENOYL-COA HYDRATASE
ECHA17

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 ARG A  44
ALA A  14
ASP A  46
GLY A  12
 None
 0.99A 1e7bA-4di1A:
undetectable		 1e7bA-4di1A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eaa PEROSAMINE
N-ACETYLTRANSFERASE

(Caulobacter
vibrioides) 		PF00132
(Hexapep) 		4 ARG A 166
ALA A 147
ASP A 184
GLY A 164
 None
 1.12A 1e7bA-4eaaA:
undetectable		 1e7bA-4eaaA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eaa PEROSAMINE
N-ACETYLTRANSFERASE

(Caulobacter
vibrioides) 		PF00132
(Hexapep) 		4 ARG A 166
ALA A 148
ASP A 184
GLY A 164
 None
 1.02A 1e7bA-4eaaA:
undetectable		 1e7bA-4eaaA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Salipiger
bermudensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 167
ALA A 166
ASP A 172
GLY A 194
 None
 1.16A 1e7bA-4h2hA:
undetectable		 1e7bA-4h2hA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7m ENDO-1,4-BETA-GLUCAN
ASE

(Trichoderma
harzianum) 		PF01670
(Glyco_hydro_12) 		4 ARG A 100
ALA A 101
ASP A 133
GLY A 135
 None
 0.92A 1e7bA-4h7mA:
undetectable		 1e7bA-4h7mA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hav RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00638
(Ran_BP1) 		4 ARG B  90
ALA B  91
ASP B 129
GLY B 107
 None
 1.12A 1e7bA-4havB:
undetectable		 1e7bA-4havB:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		4 ARG A  63
ALA A  62
ASP A  65
GLY A  67
 None
 0.95A 1e7bA-4i8qA:
undetectable		 1e7bA-4i8qA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ARG A 253
ALA A 252
ASP A  88
GLY A  90
 None
 1.20A 1e7bA-4jb6A:
undetectable		 1e7bA-4jb6A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2u ANTIBODY LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG L  24
ALA L  25
ASP L  70
GLY L  68
 None
 1.10A 1e7bA-4k2uL:
undetectable		 1e7bA-4k2uL:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT

(Desulfomicrobium
baculatum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ARG S 146
ALA S 128
ASP S 147
GLY S 130
 None
 1.11A 1e7bA-4ko2S:
0.3		 1e7bA-4ko2S:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp2 HOMOACONITASE LARGE
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		4 ARG A 306
ALA A 333
ASP A 309
GLY A 300
 None
 0.80A 1e7bA-4kp2A:
undetectable		 1e7bA-4kp2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE

(Aspergillus
nidulans) 		PF16363
(GDP_Man_Dehyd) 		4 ARG A 312
ALA A 249
ASP A 241
GLY A 247
 IOD  A 405 (-3.7A)
UPG  A 401 (-3.2A)
None
None
 0.94A 1e7bA-4lisA:
undetectable		 1e7bA-4lisA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ARG A 422
ALA A 421
ASP A 387
GLY A 417
 None
 1.20A 1e7bA-4m8uA:
undetectable		 1e7bA-4m8uA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		4 LYS A  53
ALA A  52
ASP A  64
GLY A   6
 None
 1.14A 1e7bA-4mioA:
2.3		 1e7bA-4mioA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 4 ARG E 210
ALA E 185
ASP E 232
GLY E 183
 None
 1.07A 1e7bA-4obuE:
undetectable		 1e7bA-4obuE:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfq HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Brachybacterium
faecium) 		PF00156
(Pribosyltran) 		4 ARG A 157
ALA A 154
ASP A 174
GLY A 172
 None
 1.01A 1e7bA-4pfqA:
undetectable		 1e7bA-4pfqA:
18.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 ARG A 209
LYS A 212
ALA A 213
ASP A 324
GLY A 328
 NPS  A 602 (-3.6A)
None
NPS  A 602 (-3.3A)
NPS  A 602 ( 4.4A)
NPS  A 602 (-3.8A)
 0.86A 1e7bA-4po0A:
46.2		 1e7bA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A 688
LYS A 692
ALA A 691
GLY A 686
 None
 1.02A 1e7bA-4rcnA:
undetectable		 1e7bA-4rcnA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		4 ARG A  86
ALA A  85
ASP A 347
GLY A  80
 None
 0.98A 1e7bA-4wgxA:
undetectable		 1e7bA-4wgxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvj ANTIBODY HEAVY CHAIN
VARIABLE DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		4 ARG H  38
ALA H  40
ASP H  90
GLY H 136
 None
 1.16A 1e7bA-4xvjH:
undetectable		 1e7bA-4xvjH:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Trichophyton
rubrum) 		no annotation 4 LYS D 111
ALA D 110
ASP D  90
GLY D  93
 None
 1.15A 1e7bA-4zhsD:
0.1		 1e7bA-4zhsD:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4znj PHAGE TERMINASE
LARGE SUBUNIT

(Thermus virus
P74-26) 		PF03237
(Terminase_6) 		4 ARG A 170
ALA A 141
ASP A 144
GLY A  63
 None
 1.06A 1e7bA-4znjA:
undetectable		 1e7bA-4znjA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ARG R 286
ALA R 272
ASP R 269
GLY R 248
 None
 1.11A 1e7bA-5a31R:
undetectable		 1e7bA-5a31R:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 ARG A 278
ALA A  50
ASP A 145
GLY A 149
 None
 1.16A 1e7bA-5ce9A:
undetectable		 1e7bA-5ce9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqb DITRANS,POLYCIS-UNDE
CAPRENYL-DIPHOSPHATE
SYNTHASE
((2E,6E)-FARNESYL-DI
PHOSPHATE SPECIFIC)

(Escherichia
coli) 		PF01255
(Prenyltransf) 		4 ARG A  39
LYS A  33
ALA A  32
GLY A  27
 None
 1.00A 1e7bA-5cqbA:
undetectable		 1e7bA-5cqbA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 ARG B 417
ALA B 416
ASP B 384
GLY B 412
 BGC  B 601 ( 4.8A)
None
None
None
 1.19A 1e7bA-5do8B:
undetectable		 1e7bA-5do8B:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6

(Homo sapiens) 		PF07571
(TAF6_C) 		4 ARG J 335
ALA J 338
ASP J 331
GLY J 379
 None
 0.97A 1e7bA-5furJ:
2.2		 1e7bA-5furJ:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 ARG A 150
ALA A 146
ASP A 189
GLY A 159
 None
 1.19A 1e7bA-5hxaA:
undetectable		 1e7bA-5hxaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idu ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Paraburkholderia
phymatum) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  86
ALA A 258
ASP A  97
GLY A 262
 None
 1.16A 1e7bA-5iduA:
undetectable		 1e7bA-5iduA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsc PUTATIVE ACYL-COA
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  87
ALA A 259
ASP A  98
GLY A 263
 None
 1.15A 1e7bA-5jscA:
undetectable		 1e7bA-5jscA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A 538
ALA A 510
ASP A 540
GLY A 501
 GAL  A1000 (-4.4A)
GAL  A1000 ( 4.4A)
None
None
 1.04A 1e7bA-5k6oA:
undetectable		 1e7bA-5k6oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov PL-2 SCFV CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 ARG C1024
ALA C1025
ASP C1070
GLY C1068
 None
 1.20A 1e7bA-5kovC:
undetectable		 1e7bA-5kovC:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1x HMPV F1 SUBUNIT

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		4 ARG B 304
ALA B 288
ASP B 306
GLY B 308
 None
 1.18A 1e7bA-5l1xB:
undetectable		 1e7bA-5l1xB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03147
(FDX-ACB) 		4 ARG A 271
ALA A 268
ASP A 133
GLY A 131
 None
 1.17A 1e7bA-5mgvA:
undetectable		 1e7bA-5mgvA:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 4 ARG A 208
ALA A 212
ASP A 323
GLY A 327
 None
 0.43A 1e7bA-5oriA:
45.9		 1e7bA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 4 ARG A 208
LYS A 211
ALA A 212
ASP A 323
 None
 1.11A 1e7bA-5oriA:
45.9		 1e7bA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf8 POTENTIAL
ADP-RIBOSYLATION
FACTOR

(Candida
albicans) 		PF00025
(Arf) 		4 ARG A  99
ALA A 103
ASP A  26
GLY A  24
 None
 1.17A 1e7bA-5uf8A:
undetectable		 1e7bA-5uf8A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 ARG A 151
ALA A 147
ASP A 190
GLY A 160
 None
 1.12A 1e7bA-5v0tA:
undetectable		 1e7bA-5v0tA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzm GROUP IIE SECRETORY
PHOSPHOLIPASE A2

(Homo sapiens) 		no annotation 4 LYS A 107
ALA A 109
ASP A  37
GLY A  24
 None
None
None
CA  A 209 (-4.2A)
 1.12A 1e7bA-5wzmA:
undetectable		 1e7bA-5wzmA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 4 ARG A 209
ALA A 213
ASP A 324
GLY A 328
 None
 0.49A 1e7bA-5yxeA:
47.6		 1e7bA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 4 ARG A 209
LYS A 212
ALA A 213
GLY A 328
 None
 0.63A 1e7bA-5yxeA:
47.6		 1e7bA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 4 ARG A1856
ALA A1888
ASP A1854
GLY A1892
 None
 1.10A 1e7bA-6bq1A:
undetectable		 1e7bA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP2

(Escherichia
virus N4) 		no annotation 4 ARG B  91
ALA B  94
ASP B 389
GLY B  89
 None
 1.13A 1e7bA-6c2jB:
undetectable		 1e7bA-6c2jB:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dzs HOMOSERINE
DEHYDROGENASE

(Mycolicibacterium
hassiacum) 		no annotation 4 ARG A  72
ALA A  11
ASP A  74
GLY A   9
 None
 0.87A 1e7bA-6dzsA:
1.2		 1e7bA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehv SCFV ABVANCE:
INCREASING OUR
KNOWLEDGE OF
ANTIBODY STRUCTURAL
SPACE TO ENABLE
FASTER AND BETTER
DECISION MAKING IN
DRUG DISCOVERY

(Homo sapiens) 		no annotation 4 ARG X 158
ALA X 159
ASP X 205
GLY X 203
 None
 1.06A 1e7bA-6ehvX:
undetectable		 1e7bA-6ehvX:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 4 ARG D 361
ALA D 134
ASP D 335
GLY D 155
 None
 1.15A 1e7bA-6f5dD:
undetectable		 1e7bA-6f5dD:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 4 LYS A 200
ALA A 199
ASP A 396
GLY A 394
 None
 1.19A 1e7bA-6f8zA:
undetectable		 1e7bA-6f8zA:
8.21