SIMILAR PATTERNS OF AMINO ACIDS FOR 1E7A_B_PFLB4002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		4 LEU A 228
VAL A  60
VAL A 217
GLN A 219
 None
 1.11A 1e7aB-1a4sA:
1.1		 1e7aB-1a4sA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 PHE A  60
LEU A   9
VAL A 128
VAL A 199
 None
 0.94A 1e7aB-1b25A:
0.1		 1e7aB-1b25A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1djs PROTEIN (FIBROBLAST
GROWTH FACTOR
RECEPTOR 2)

(Homo sapiens) 		PF07679
(I-set) 		4 PHE A 334
LEU A 357
VAL A 274
VAL A 270
 None
 0.73A 1e7aB-1djsA:
undetectable		 1e7aB-1djsA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dp2 RHODANESE

(Bos taurus) 		PF00581
(Rhodanese) 		4 PHE A 130
LEU A  15
VAL A  19
VAL A 140
 None
 1.09A 1e7aB-1dp2A:
0.0		 1e7aB-1dp2A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		4 PHE A 216
LEU A 187
VAL A 145
VAL A 200
 None
 0.81A 1e7aB-1dysA:
0.0		 1e7aB-1dysA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A 104
VAL A  19
VAL A  15
GLN A  79
 None
 1.00A 1e7aB-1fn4A:
undetectable		 1e7aB-1fn4A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i3g ANTIBODY FV FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 LEU L 145
VAL L  19
VAL L  15
GLN L  97
 None
 1.05A 1e7aB-1i3gL:
undetectable		 1e7aB-1i3gL:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 PHE A 273
LEU A 395
VAL A  36
VAL A 279
 None
 1.08A 1e7aB-1ig8A:
0.4		 1e7aB-1ig8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU E 104
VAL E  19
VAL E  15
GLN E  79
 None
 1.09A 1e7aB-1nfdE:
undetectable		 1e7aB-1nfdE:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9n MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
B

(Escherichia
coli) 		PF03205
(MobB) 		4 LEU A 127
VAL A 136
VAL A 140
SER A 138
 None
 0.79A 1e7aB-1p9nA:
0.0		 1e7aB-1p9nA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tx4 P50-RHOGAP

(Homo sapiens) 		PF00620
(RhoGAP) 		4 PHE A  45
LEU A 128
VAL A  65
GLN A  44
 None
 1.11A 1e7aB-1tx4A:
0.0		 1e7aB-1tx4A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urd MALTOSE-BINDING
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01547
(SBP_bac_1) 		4 LEU A 309
VAL A  34
SER A  36
GLN A  38
 None
None
None
MLR  A1400 (-3.0A)
 1.01A 1e7aB-1urdA:
0.9		 1e7aB-1urdA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vk1 CONSERVED
HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF02195
(ParBc) 		4 PHE A  20
LEU A  77
VAL A  44
VAL A 236
 None
 1.04A 1e7aB-1vk1A:
0.0		 1e7aB-1vk1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)

(Mus musculus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 LEU B 342
VAL B 393
VAL B 431
GLN B 381
 None
 0.85A 1e7aB-1vkxB:
1.0		 1e7aB-1vkxB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		4 LEU A  53
VAL A  33
VAL A  13
GLN A  57
 None
 0.92A 1e7aB-1wniA:
undetectable		 1e7aB-1wniA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4m FAR UPSTREAM ELEMENT
BINDING PROTEIN 1

(Mus musculus) 		PF00013
(KH_1) 		4 LEU A  64
VAL A  80
VAL A  73
GLN A  17
 None
 1.12A 1e7aB-1x4mA:
undetectable		 1e7aB-1x4mA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 LEU A  36
VAL A  40
VAL A  44
GLN A  27
 None
 1.09A 1e7aB-1yzyA:
undetectable		 1e7aB-1yzyA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE

(Streptococcus
pyogenes) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 LEU A 106
VAL A 137
VAL A  61
GLN A  81
 None
 1.12A 1e7aB-2ahrA:
undetectable		 1e7aB-2ahrA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7h EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A  26
VAL A  79
SER A  98
GLN A  99
 None
 1.05A 1e7aB-2e7hA:
undetectable		 1e7aB-2e7hA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 PHE A 691
LEU A 433
VAL A 439
GLN A 451
 None
 1.07A 1e7aB-2e7zA:
undetectable		 1e7aB-2e7zA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 PHE A 225
LEU A 222
VAL A  34
VAL A 371
 None
 0.89A 1e7aB-2efjA:
1.8		 1e7aB-2efjA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 4 PHE A 165
LEU A  92
VAL A 109
VAL A 142
 None
 1.06A 1e7aB-2f9rA:
undetectable		 1e7aB-2f9rA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		4 LEU A 133
VAL A 138
VAL A 240
GLN A 244
 None
 1.03A 1e7aB-2jgpA:
undetectable		 1e7aB-2jgpA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ngr PROTEIN (GTPASE
ACTIVATING PROTEIN
(RHG))

(Homo sapiens) 		PF00620
(RhoGAP) 		4 PHE B 265
LEU B 348
VAL B 285
GLN B 264
 None
 1.11A 1e7aB-2ngrB:
undetectable		 1e7aB-2ngrB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nps SYNTAXIN-6
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4

(Homo sapiens;
Mus musculus) 		PF00957
(Synaptobrevin)
no annotation 		4 PHE A  99
LEU A 106
VAL D 225
VAL D 218
 None
 1.12A 1e7aB-2npsA:
undetectable		 1e7aB-2npsA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF06032
(DUF917) 		4 PHE A 332
LEU A 236
VAL A 241
VAL A 324
 None
 0.77A 1e7aB-2o3iA:
undetectable		 1e7aB-2o3iA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p28 INTEGRIN BETA-2

(Homo sapiens) 		PF17205
(PSI_integrin)
no annotation 		4 PHE B 411
LEU B 347
VAL A  95
GLN A  75
 None
 1.12A 1e7aB-2p28B:
undetectable		 1e7aB-2p28B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo sapiens) 		PF00878
(CIMR) 		4 PHE A1637
VAL A1587
VAL A1609
SER A1611
 None
 0.96A 1e7aB-2v5nA:
undetectable		 1e7aB-2v5nA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PHE A 502
LEU A 535
VAL A 468
VAL A 451
 None
 1.08A 1e7aB-2vk4A:
undetectable		 1e7aB-2vk4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 308
VAL A 328
VAL A 287
GLN A 280
 None
 1.09A 1e7aB-2vosA:
undetectable		 1e7aB-2vosA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 258
LEU A 322
VAL A 278
VAL A 263
 None
 0.93A 1e7aB-2vwkA:
undetectable		 1e7aB-2vwkA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 LEU A  74
VAL A  93
VAL A  78
GLN A  87
 None
 1.06A 1e7aB-2x3kA:
undetectable		 1e7aB-2x3kA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 672
VAL A 670
VAL A 634
GLN A 636
 None
 1.05A 1e7aB-2x40A:
undetectable		 1e7aB-2x40A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		4 LEU A  86
VAL A  66
VAL A 116
GLN A 120
 None
 1.01A 1e7aB-2yg8A:
undetectable		 1e7aB-2yg8A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0r SENSOR PROTEIN

(Thermotoga
maritima) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		4 LEU A 614
VAL A 618
VAL A 654
GLN A 653
 None
 0.87A 1e7aB-3a0rA:
undetectable		 1e7aB-3a0rA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 258
LEU A 322
VAL A 278
VAL A 263
 None
 1.02A 1e7aB-3a2fA:
undetectable		 1e7aB-3a2fA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		4 LEU A 463
VAL A 437
SER A 440
GLN A 551
 None
GOL  A5002 (-3.3A)
None
None
 0.86A 1e7aB-3abzA:
undetectable		 1e7aB-3abzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		4 LEU B 136
VAL B 144
VAL B 106
GLN B 164
 None
 0.89A 1e7aB-3adaB:
undetectable		 1e7aB-3adaB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7e H16.V5 FAB LIGHT
CHAIN

(Mus musculus) 		no annotation 4 LEU L 110
VAL L  19
VAL L  15
GLN L  85
 None
 0.89A 1e7aB-3j7eL:
undetectable		 1e7aB-3j7eL:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		4 PHE B 212
LEU B 157
VAL B 268
VAL B 446
 None
 1.07A 1e7aB-3jb9B:
undetectable		 1e7aB-3jb9B:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
sp. ADP1) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 LEU A 255
VAL A 234
VAL A 227
GLN A 228
 None
 1.11A 1e7aB-3k1nA:
undetectable		 1e7aB-3k1nA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2p UDP-N-ACETYLGLUCOSAM
INE 4-EPIMERASE

(Bacillus cereus) 		PF01370
(Epimerase) 		4 LEU A 156
VAL A 103
VAL A 216
GLN A 213
 None
 0.92A 1e7aB-3m2pA:
0.6		 1e7aB-3m2pA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmh METHIONINE-R-SULFOXI
DE REDUCTASE

(Neisseria
meningitidis) 		PF13185
(GAF_2) 		4 LEU A  64
VAL A 130
VAL A  84
GLN A  87
 None
None
SME  A 168 (-3.8A)
None
 1.14A 1e7aB-3mmhA:
undetectable		 1e7aB-3mmhA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		4 LEU A 348
VAL A 357
VAL A 365
GLN A 405
 None
 1.07A 1e7aB-3n6xA:
undetectable		 1e7aB-3n6xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr1 HD DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF13328
(HD_4) 		4 LEU A  43
VAL A 118
VAL A  53
GLN A  56
 None
 1.12A 1e7aB-3nr1A:
undetectable		 1e7aB-3nr1A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE

(Shewanella
baltica) 		PF01182
(Glucosamine_iso) 		4 LEU A 156
VAL A 210
VAL A 218
GLN A 221
 None
 0.92A 1e7aB-3nwpA:
undetectable		 1e7aB-3nwpA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 PHE A 769
LEU A 711
VAL A  55
VAL A 695
 None
 1.00A 1e7aB-3o5aA:
undetectable		 1e7aB-3o5aA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		4 PHE A 311
LEU A 291
VAL A 277
VAL A 270
 None
 1.14A 1e7aB-3rhgA:
undetectable		 1e7aB-3rhgA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU A 151
VAL A 140
VAL A 324
GLN A 322
 None
 0.99A 1e7aB-3ut3A:
undetectable		 1e7aB-3ut3A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 PHE A 403
LEU A 385
VAL A 410
GLN A 408
 None
 1.14A 1e7aB-3v8uA:
undetectable		 1e7aB-3v8uA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 PHE A 400
LEU A 382
VAL A 407
GLN A 405
 None
 1.12A 1e7aB-3ve2A:
undetectable		 1e7aB-3ve2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vk6 E3 UBIQUITIN-PROTEIN
LIGASE HAKAI

(Mus musculus) 		no annotation 4 LEU A  58
VAL A  23
VAL A  13
GLN A  52
 None
 0.97A 1e7aB-3vk6A:
undetectable		 1e7aB-3vk6A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE

(Sporosarcina
psychrophila) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A  74
VAL A 291
VAL A 285
SER A 288
 None
 0.93A 1e7aB-3vpxA:
undetectable		 1e7aB-3vpxA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w64 MAGNETOSOME PROTEIN
MAMM

(Magnetospirillum
gryphiswaldense) 		PF16916
(ZT_dimer) 		4 LEU A 284
VAL A 274
VAL A 217
GLN A 218
 None
 0.95A 1e7aB-3w64A:
undetectable		 1e7aB-3w64A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli) 		PF01728
(FtsJ) 		4 LEU A 137
VAL A 148
VAL A  90
GLN A  94
 None
 0.89A 1e7aB-4aukA:
undetectable		 1e7aB-4aukA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn2 KINESIN-LIKE PROTEIN
KIF15

(Homo sapiens) 		PF00225
(Kinesin) 		4 LEU A 247
VAL A  80
VAL A 121
SER A 125
 None
 1.06A 1e7aB-4bn2A:
undetectable		 1e7aB-4bn2A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 VAL A 912
VAL A 938
SER A 941
GLN A 942
 None
 0.82A 1e7aB-4c3hA:
undetectable		 1e7aB-4c3hA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6r DISEASE RESISTANCE
PROTEIN RPS4

(Arabidopsis
thaliana) 		PF01582
(TIR) 		4 PHE A  31
LEU A  72
VAL A 171
VAL A 164
 None
 1.06A 1e7aB-4c6rA:
undetectable		 1e7aB-4c6rA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		4 PHE A 296
LEU A 291
VAL A 268
VAL A 263
 None
 1.11A 1e7aB-4dppA:
undetectable		 1e7aB-4dppA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 233
VAL A 198
SER A 191
GLN A 192
 None
 1.11A 1e7aB-4dzaA:
undetectable		 1e7aB-4dzaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eiu UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		4 VAL A 191
VAL A 151
SER A 229
GLN A 228
 None
None
None
PEG  A 307 (-4.9A)
 1.12A 1e7aB-4eiuA:
undetectable		 1e7aB-4eiuA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 258
LEU A 322
VAL A 278
VAL A 263
 PHE  A 258 ( 1.3A)
LEU  A 322 ( 0.6A)
VAL  A 278 ( 0.6A)
VAL  A 263 ( 0.6A)
 0.89A 1e7aB-4flxA:
undetectable		 1e7aB-4flxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k07 AMYLOIDOGENIC
IMMUNOGLOBULIN LIGHT
CHAIN PROTEIN AL-103

(Homo sapiens) 		PF07686
(V-set) 		4 LEU A 104
VAL A  19
VAL A  15
GLN A  79
 None
 1.00A 1e7aB-4k07A:
undetectable		 1e7aB-4k07A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkj TRANSCOBALAMIN-1

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 PHE A 258
LEU A 250
VAL A   5
VAL A 267
 None
 0.96A 1e7aB-4kkjA:
undetectable		 1e7aB-4kkjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 PHE A 309
VAL A 356
VAL A 314
GLN A  10
 None
 0.96A 1e7aB-4m9dA:
1.7		 1e7aB-4m9dA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maq PUTATIVE
FUMARYLPYRUVATE
HYDROLASE

(Burkholderia
cenocepacia) 		PF01557
(FAA_hydrolase) 		4 PHE A 198
LEU A 112
VAL A  68
VAL A 140
 None
 1.04A 1e7aB-4maqA:
undetectable		 1e7aB-4maqA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF00171
(Aldedh) 		4 LEU A 344
VAL A 353
VAL A 373
GLN A 387
 None
 1.13A 1e7aB-4ou2A:
undetectable		 1e7aB-4ou2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 LEU A 118
VAL A  50
VAL A  64
GLN A  75
 None
 1.13A 1e7aB-4p72A:
undetectable		 1e7aB-4p72A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''

(Thermococcus
kodakarensis) 		PF04998
(RNA_pol_Rpb1_5) 		4 VAL C 300
VAL C  67
SER C  71
GLN C  70
 None
 1.11A 1e7aB-4qiwC:
2.7		 1e7aB-4qiwC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnw CHANOCLAVINE-I
ALDEHYDE REDUCTASE

(Aspergillus
fumigatus) 		PF00724
(Oxidored_FMN) 		4 LEU A 226
VAL A 224
VAL A 207
GLN A 251
 None
 1.08A 1e7aB-4qnwA:
undetectable		 1e7aB-4qnwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpa PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 PHE A 207
LEU A 249
VAL A 274
VAL A 300
 None
 0.84A 1e7aB-4rpaA:
undetectable		 1e7aB-4rpaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS

(Mycoplasma
pneumoniae) 		PF02917
(Pertussis_S1) 		4 PHE A 528
LEU A 477
VAL A 357
VAL A 444
 ACT  A 608 (-4.6A)
None
None
None
 1.11A 1e7aB-4tlvA:
undetectable		 1e7aB-4tlvA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tuf MAJOR EXTRACELLULAR
ENDOGLUCANASE

(Xanthomonas
campestris) 		PF00150
(Cellulase) 		4 PHE A  52
LEU A 133
VAL A 174
VAL A 120
 None
 0.99A 1e7aB-4tufA:
undetectable		 1e7aB-4tufA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uym 14-ALPHA STEROL
DEMETHYLASE

(Aspergillus
fumigatus) 		PF00067
(p450) 		4 PHE A 486
LEU A 333
VAL A 362
VAL A 320
 None
 0.70A 1e7aB-4uymA:
undetectable		 1e7aB-4uymA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE IRON
PROTEIN 1

(Azotobacter
vinelandii) 		PF00142
(Fer4_NifH) 		4 LEU E 109
VAL E  86
VAL E 102
SER E  88
 None
 1.11A 1e7aB-4wzbE:
undetectable		 1e7aB-4wzbE:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		4 PHE A1240
LEU A1283
VAL A1315
VAL A1257
 None
 0.97A 1e7aB-4ziuA:
undetectable		 1e7aB-4ziuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 PHE A1240
LEU A1283
VAL A1315
VAL A1257
 None
 0.89A 1e7aB-5a42A:
undetectable		 1e7aB-5a42A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		4 LEU A  15
VAL A  93
VAL A  89
GLN A 116
 None
 1.12A 1e7aB-5b5rA:
0.7		 1e7aB-5b5rA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 PHE A 855
LEU A 684
VAL A 731
VAL A 861
 None
 1.01A 1e7aB-5d0fA:
undetectable		 1e7aB-5d0fA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhy ANTI-REV ANTIBODY
FAB SINGLE-CHAIN
VARIABLE FRAGMENT,
LIGHT CHAIN

(Oryctolagus
cuniculus) 		PF07686
(V-set) 		4 LEU B 107
VAL B  19
VAL B  15
GLN B  79
 None
 0.95A 1e7aB-5dhyB:
undetectable		 1e7aB-5dhyB:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn7 PROTEIN FAM179B

(Mus musculus) 		no annotation 4 LEU A 414
VAL A 442
VAL A 435
SER A 439
 None
 0.95A 1e7aB-5dn7A:
undetectable		 1e7aB-5dn7A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewt EXODEOXYRIBONUCLEASE
III XTH

(Sulfolobus
islandicus) 		PF03372
(Exo_endo_phos) 		4 PHE A  28
LEU A  19
VAL A   8
VAL A   4
 None
 0.98A 1e7aB-5ewtA:
undetectable		 1e7aB-5ewtA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f07 PUTATIVE GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A  35
VAL A  54
VAL A  12
GLN A  15
 GSH  A 301 ( 4.1A)
GSH  A 301 (-3.8A)
GSH  A 301 (-4.3A)
None
 0.93A 1e7aB-5f07A:
undetectable		 1e7aB-5f07A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A

(Homo sapiens) 		PF06105
(Aph-1) 		4 LEU C 170
VAL C 220
VAL C 193
SER C 196
 None
 1.07A 1e7aB-5fn4C:
undetectable		 1e7aB-5fn4C:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE

(Pyrococcus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 258
LEU A 322
VAL A 278
VAL A 263
 None
 1.02A 1e7aB-5h12A:
undetectable		 1e7aB-5h12A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imy VAGINOLYSIN

(Gardnerella
vaginalis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 PHE A 295
LEU A 221
VAL A 238
GLN A 236
 None
 1.07A 1e7aB-5imyA:
undetectable		 1e7aB-5imyA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzi HCV1406 TCR ALPHA
CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 LEU D 113
VAL D  24
SER D  87
GLN D  88
 None
 1.02A 1e7aB-5jziD:
undetectable		 1e7aB-5jziD:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko9 EMBRYONIC STEM
CELL-SPECIFIC
5-HYDROXYMETHYLCYTOS
INE-BINDING PROTEIN

(Homo sapiens) 		PF02586
(SRAP) 		4 LEU A 238
VAL A 102
VAL A 200
SER A  99
 None
 1.09A 1e7aB-5ko9A:
undetectable		 1e7aB-5ko9A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kt0 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Trichormus
variabilis) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		4 VAL A 194
VAL A 185
SER A 188
GLN A 189
 None
 0.83A 1e7aB-5kt0A:
0.9		 1e7aB-5kt0A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2
POLYCOMB PROTEIN
SUZ12

(Homo sapiens) 		PF00856
(SET)
PF09733
(VEFS-Box)
PF11616
(EZH2_WD-Binding) 		4 LEU C 658
VAL A 442
VAL A 272
SER A 438
 None
 1.00A 1e7aB-5ls6C:
undetectable		 1e7aB-5ls6C:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG

(Homo sapiens) 		PF04821
(TIMELESS) 		4 PHE A 345
LEU A 198
VAL A 163
VAL A 222
 None
 0.95A 1e7aB-5mqiA:
undetectable		 1e7aB-5mqiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nen LIPASE C

(Serratia
marcescens) 		no annotation 4 LEU A 174
VAL A 208
VAL A 201
GLN A 202
 None
 1.06A 1e7aB-5nenA:
undetectable		 1e7aB-5nenA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0l ARYL HYDROCARBON
RECEPTOR

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS) 		4 PHE B 168
LEU B 159
VAL B 151
VAL B 127
 None
 1.11A 1e7aB-5v0lB:
undetectable		 1e7aB-5v0lB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF00400
(WD40)
PF12937
(F-box-like) 		4 LEU B2403
VAL B2424
SER B2427
GLN B2428
 None
None
None
SO4  B2804 (-3.7A)
 1.11A 1e7aB-5v4bB:
undetectable		 1e7aB-5v4bB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xau LAMININ SUBUNIT
ALPHA-5
LAMININ SUBUNIT
BETA-1
LAMININ SUBUNIT
GAMMA-1

(Homo sapiens) 		PF02210
(Laminin_G_2)
PF06009
(Laminin_II)
no annotation 		4 LEU C1596
VAL A2733
VAL B1781
GLN B1777
 None
 0.97A 1e7aB-5xauC:
undetectable		 1e7aB-5xauC:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 4 LEU A 160
VAL A 181
VAL A 148
GLN A 157
 None
 0.98A 1e7aB-5xixA:
undetectable		 1e7aB-5xixA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029

(Streptococcus
pneumoniae) 		no annotation 4 LEU A 320
VAL A 339
SER A 342
GLN A 343
 None
 1.08A 1e7aB-5xj1A:
undetectable		 1e7aB-5xj1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 4 LEU A 201
VAL A 222
VAL A 231
GLN A 235
 None
None
None
GOL  A 401 (-4.0A)
 1.08A 1e7aB-5yatA:
undetectable		 1e7aB-5yatA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwl PAL

(Bacillus
thuringiensis) 		no annotation 4 PHE A  11
LEU A  79
VAL A 226
VAL A 219
 NAD  A 401 (-4.8A)
NAD  A 401 (-4.4A)
None
None
 1.10A 1e7aB-6bwlA:
0.4		 1e7aB-6bwlA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A   8
VAL A 508
VAL A 553
GLN A 555
 None
 1.07A 1e7aB-6eojA:
undetectable		 1e7aB-6eojA:
16.83