SIMILAR PATTERNS OF AMINO ACIDS FOR 1E7A_A_PFLA4001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dml DNA POLYMERASE
PROCESSIVITY FACTOR


(Human
alphaherpesvirus
1)
PF02282
(Herpes_UL42)
5 LEU A 288
LEU A 189
VAL A 283
GLY A 284
ALA A 303
None
1.31A 1e7aA-1dmlA:
undetectable
1e7aA-1dmlA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18')
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C)
5 ILE P 236
LEU P 247
VAL P 323
GLY P 322
ALA P 320
None
1.21A 1e7aA-1h71P:
undetectable
1e7aA-1h71P:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3g CYTOCHROME C-553

(Sporosarcina
pasteurii)
PF13442
(Cytochrome_CBB3)
5 LEU A  61
ILE A  64
VAL A  27
CYH A  32
ALA A  76
None
HEC  A  93 (-3.6A)
None
HEC  A  93 (-1.8A)
HEC  A  93 ( 3.6A)
1.00A 1e7aA-1k3gA:
undetectable
1e7aA-1k3gA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN


(Archaeoglobus
fulgidus)
PF01269
(Fibrillarin)
5 LEU A 143
ILE A 142
VAL A  87
GLY A  65
ALA A 114
None
None
None
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.4A)
1.21A 1e7aA-1nt2A:
undetectable
1e7aA-1nt2A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN


(Torpedo
marmorata)
PF02932
(Neur_chan_memb)
5 LEU E 457
ILE E 454
ASN E 300
VAL E 307
ALA E 450
None
0.93A 1e7aA-1oedE:
3.1
1e7aA-1oedE:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq7 TRIOSEPHOSPHATE
ISOMERASE


(Gallus gallus)
PF00121
(TIM)
5 LEU A  24
ILE A  25
VAL A  61
GLY A  60
ALA A  51
None
1.06A 1e7aA-1sq7A:
undetectable
1e7aA-1sq7A:
18.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
8 LEU A 387
ILE A 388
ASN A 391
LEU A 407
ARG A 410
VAL A 433
GLY A 434
ALA A 449
None
0.74A 1e7aA-1tf0A:
47.1
1e7aA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2


(Streptomyces
coelicolor)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 LEU B 234
ILE B 233
VAL B  11
GLY B 230
ALA B  78
None
1.30A 1e7aA-1tqyB:
undetectable
1e7aA-1tqyB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9t CYCLOPHILIN B

(Escherichia
coli)
PF00160
(Pro_isomerase)
5 LEU A 160
ILE A 159
ASN A  43
GLY A  39
ALA A 162
None
1.29A 1e7aA-1v9tA:
undetectable
1e7aA-1v9tA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE


(Zea mays)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
5 LEU A 499
ILE A 428
VAL A 471
GLY A 503
CYH A 469
None
1.23A 1e7aA-1vbgA:
undetectable
1e7aA-1vbgA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Thermus
thermophilus)
PF01070
(FMN_dh)
5 LEU A 277
ILE A 247
VAL A 265
GLY A 263
ALA A 261
None
None
None
FMN  A 501 (-3.2A)
None
1.28A 1e7aA-1vcgA:
undetectable
1e7aA-1vcgA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve2 UROPORPHYRIN-III
C-METHYLTRANSFERASE


(Thermus
thermophilus)
PF00590
(TP_methylase)
5 LEU A 215
LEU A 129
VAL A 222
GLY A 219
ALA A 183
None
1.30A 1e7aA-1ve2A:
undetectable
1e7aA-1ve2A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybd URIDYLATE KINASE

(Neisseria
meningitidis)
PF00696
(AA_kinase)
5 LEU A  21
ILE A  34
LEU A  14
GLY A  39
ALA A  94
None
1.17A 1e7aA-1ybdA:
undetectable
1e7aA-1ybdA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yob FLAVODOXIN 2

(Azotobacter
vinelandii)
PF00258
(Flavodoxin_1)
5 LEU A 168
ILE A 171
LEU A 151
GLY A 148
ALA A  92
None
0.78A 1e7aA-1yobA:
undetectable
1e7aA-1yobA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE


(Sulfolobus
solfataricus)
PF00218
(IGPS)
5 LEU A  38
ILE A  37
ASN A  34
ARG A 175
ALA A 229
None
1.21A 1e7aA-2c3zA:
undetectable
1e7aA-2c3zA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffj CONSERVED
HYPOTHETICAL PROTEIN


(Archaeoglobus
fulgidus)
PF01937
(DUF89)
5 ILE A  29
LEU A  37
VAL A  15
GLY A  13
ALA A  19
None
1.31A 1e7aA-2ffjA:
2.8
1e7aA-2ffjA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flq NITRIC OXIDE
SYNTHASE


(Geobacillus
stearothermophilus)
PF02898
(NO_synthase)
5 LEU A 213
ILE A 202
LEU A 263
GLY A 250
ALA A 292
None
1.11A 1e7aA-2flqA:
2.4
1e7aA-2flqA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzx PUTATIVE TATD
RELATED DNASE


(Staphylococcus
aureus)
PF01026
(TatD_DNase)
5 ILE A  90
LEU A 140
VAL A 148
GLY A 149
ALA A 118
None
1.23A 1e7aA-2gzxA:
undetectable
1e7aA-2gzxA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP


(Vibrio harveyi)
PF13407
(Peripla_BP_4)
5 LEU A 304
ILE A 286
VAL A 268
GLY A 244
ALA A 263
None
1.18A 1e7aA-2hj9A:
undetectable
1e7aA-2hj9A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imh HYPOTHETICAL PROTEIN
UNP Q5LQD5_SILPO


(Ruegeria
pomeroyi)
PF06267
(DUF1028)
5 LEU A   6
ILE A 114
LEU A  59
VAL A  69
ALA A  95
None
1.26A 1e7aA-2imhA:
undetectable
1e7aA-2imhA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq7 ENDOPOLYGALACTURONAS
E


(Colletotrichum
lupini)
PF00295
(Glyco_hydro_28)
5 LEU A 142
ILE A 103
ASN A 140
VAL A 162
GLY A 138
None
1.30A 1e7aA-2iq7A:
undetectable
1e7aA-2iq7A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfd FATTY ACID SYNTHASE

(Homo sapiens)
PF00698
(Acyl_transf_1)
PF16197
(KAsynt_C_assoc)
5 LEU A 805
LEU A 438
VAL A 472
GLY A 478
ALA A 798
None
1.25A 1e7aA-2jfdA:
1.7
1e7aA-2jfdA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ


(Mycobacterium
tuberculosis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 LEU A  89
ILE A  86
LEU A  47
VAL A  58
ALA A  82
None
1.19A 1e7aA-2q1yA:
undetectable
1e7aA-2q1yA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ


(Mycobacterium
tuberculosis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 LEU A 258
ILE A 308
LEU A 124
GLY A 127
ALA A 221
None
1.15A 1e7aA-2q1yA:
undetectable
1e7aA-2q1yA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxg CG6181-PA, ISOFORM A

(Drosophila
melanogaster)
no annotation 5 ILE A1222
LEU A1289
VAL A1247
GLY A1245
ALA A1238
None
1.13A 1e7aA-2vxgA:
undetectable
1e7aA-2vxgA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus)
PF00258
(Flavodoxin_1)
5 LEU A 169
ILE A 172
LEU A 152
GLY A 149
ALA A  93
None
0.78A 1e7aA-2wc1A:
undetectable
1e7aA-2wc1A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whk MANNAN
ENDO-1,4-BETA-MANNOS
IDASE


(Bacillus
subtilis)
PF02156
(Glyco_hydro_26)
5 ILE A 249
LEU A 313
VAL A 267
GLY A 268
ALA A 241
None
1.30A 1e7aA-2whkA:
undetectable
1e7aA-2whkA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG


(Aquifex
aeolicus)
PF01134
(GIDA)
PF13932
(GIDA_assoc)
5 LEU A 400
ASN A 397
LEU A 410
GLY A 391
ALA A  25
None
1.04A 1e7aA-2zxhA:
undetectable
1e7aA-2zxhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Mus musculus)
PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD)
5 LEU A 598
ASN A 696
VAL A 658
GLY A 657
CYH A 662
None
None
None
None
ZN  A2002 (-2.1A)
1.27A 1e7aA-3av6A:
undetectable
1e7aA-3av6A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw9 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E


(Pyrobaculum
calidifontis)
PF01370
(Epimerase)
5 LEU A  16
ILE A  12
LEU A 156
VAL A 228
ALA A 205
None
NAD  A 901 (-4.4A)
None
None
None
1.14A 1e7aA-3aw9A:
undetectable
1e7aA-3aw9A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc7 PUTATIVE
UNCHARACTERIZED
PROTEIN LP_3323


(Lactobacillus
plantarum)
PF13472
(Lipase_GDSL_2)
5 LEU A  46
ILE A  45
LEU A 180
VAL A 211
GLY A 208
None
1.18A 1e7aA-3dc7A:
undetectable
1e7aA-3dc7A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dj4 BIFUNCTIONAL PROTEIN
GLMU


(Mycobacterium
tuberculosis)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 LEU A  56
ILE A  63
LEU A  41
VAL A  67
GLY A  68
None
1.10A 1e7aA-3dj4A:
undetectable
1e7aA-3dj4A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN


(Plexaura
homomalla)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
5 ILE A 716
LEU A 984
VAL A 746
GLY A 745
ALA A 695
None
0.99A 1e7aA-3dy5A:
undetectable
1e7aA-3dy5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A


(Vibrio
vulnificus)
PF06026
(Rib_5-P_isom_A)
5 LEU A  63
ILE A  65
LEU A  15
VAL A  24
ALA A  49
None
1.19A 1e7aA-3enqA:
undetectable
1e7aA-3enqA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD


(Arthrobacter
sp. FB24)
PF13794
(MiaE_2)
5 LEU A 209
ILE A 206
ARG A 216
GLY A 170
ALA A 176
None
None
None
None
UNL  A 500 ( 4.1A)
1.32A 1e7aA-3ez0A:
undetectable
1e7aA-3ez0A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 28 KDA FORM


(Mus musculus)
PF04916
(Phospholip_B)
5 LEU A 118
LEU A 205
VAL A 126
GLY A 124
ALA A  90
NAG  A  11 ( 4.3A)
None
None
None
None
1.25A 1e7aA-3fgtA:
undetectable
1e7aA-3fgtA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2


(Mus musculus)
PF04916
(Phospholip_B)
5 LEU A 118
LEU A 205
VAL A 126
GLY A 124
ALA A  90
NAG  A  11 ( 4.6A)
None
None
None
None
1.20A 1e7aA-3fgwA:
undetectable
1e7aA-3fgwA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi9 MALATE DEHYDROGENASE

(Porphyromonas
gingivalis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 LEU A 207
ILE A 202
ARG A 218
VAL A 186
ALA A 188
None
1.28A 1e7aA-3fi9A:
undetectable
1e7aA-3fi9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN


(Novosphingobium
aromaticivorans)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ILE A 156
LEU A 246
VAL A 163
GLY A 162
ALA A 167
None
None
None
CA  A 401 ( 3.7A)
None
1.21A 1e7aA-3gazA:
undetectable
1e7aA-3gazA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg2 SUGAR DEHYDROGENASE,
UDP-GLUCOSE/GDP-MANN
OSE DEHYDROGENASE
FAMILY


(Porphyromonas
gingivalis)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
5 LEU A 423
ILE A 420
LEU A 465
VAL A 468
GLY A 401
None
1.26A 1e7aA-3gg2A:
undetectable
1e7aA-3gg2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE


(Micrococcus
luteus)
PF04960
(Glutaminase)
5 LEU A 304
ILE A 255
LEU A   9
VAL A 277
GLY A 276
None
1.28A 1e7aA-3ihaA:
undetectable
1e7aA-3ihaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron)
PF00128
(Alpha-amylase)
5 LEU A 680
ASN A 643
LEU A 515
GLY A 467
ALA A 628
None
1.29A 1e7aA-3k8kA:
undetectable
1e7aA-3k8kA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE


(Staphylococcus
aureus)
PF01791
(DeoC)
5 LEU A  24
ILE A  67
LEU A  32
GLY A  74
ALA A  57
None
1.30A 1e7aA-3kaoA:
undetectable
1e7aA-3kaoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III


(Rhodopseudomonas
palustris)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 LEU A 163
ILE A 222
VAL A 170
GLY A 171
ALA A   4
None
1.28A 1e7aA-3ledA:
undetectable
1e7aA-3ledA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7a UNCHARACTERIZED
PROTEIN


(Novosphingobium
aromaticivorans)
PF02643
(DUF192)
5 LEU A 145
ILE A 112
LEU A  82
GLY A 149
ALA A 152
None
1.13A 1e7aA-3m7aA:
undetectable
1e7aA-3m7aA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE


(Homo sapiens)
PF03372
(Exo_endo_phos)
5 LEU A 532
ILE A 491
ARG A 172
GLY A 502
ALA A 469
None
1.29A 1e7aA-3ngoA:
undetectable
1e7aA-3ngoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus)
PF00008
(EGF)
PF02210
(Laminin_G_2)
5 LEU A 638
ILE A 514
VAL A 691
GLY A 690
ALA A 683
None
1.27A 1e7aA-3poyA:
undetectable
1e7aA-3poyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqz PUTATIVE
UNCHARACTERIZED
PROTEIN YJIK


(Escherichia
coli)
PF06977
(SdiA-regulated)
5 LEU A 240
LEU A 280
VAL A 297
GLY A 296
ALA A 246
None
1.01A 1e7aA-3qqzA:
undetectable
1e7aA-3qqzA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvm OLEI00960

(Oleispira
antarctica)
PF00561
(Abhydrolase_1)
5 LEU A 181
ILE A 182
ARG A  44
GLY A 187
ALA A 169
SO4  A 283 (-4.4A)
None
SO4  A 284 (-3.6A)
None
None
1.07A 1e7aA-3qvmA:
undetectable
1e7aA-3qvmA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT


(Mycobacterium
marinum)
PF00202
(Aminotran_3)
5 LEU A 443
ILE A 442
LEU A 358
GLY A 435
ALA A 402
None
1.26A 1e7aA-3r4tA:
undetectable
1e7aA-3r4tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqh QUINONE
OXIDOREDUCTASE


(Coxiella
burnetii)
PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2)
5 LEU A 275
LEU A 142
VAL A 162
GLY A 163
ALA A 134
None
None
NDP  A 500 (-3.7A)
None
None
1.10A 1e7aA-3tqhA:
undetectable
1e7aA-3tqhA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE


(Pseudomonas
aeruginosa)
PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4)
5 ILE A 239
LEU A 250
VAL A 326
GLY A 325
ALA A 323
None
1.22A 1e7aA-3vi1A:
undetectable
1e7aA-3vi1A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY


(Thermus
thermophilus)
PF00440
(TetR_N)
5 LEU A 130
ILE A 129
LEU A 155
GLY A  66
ALA A  78
None
1.22A 1e7aA-3vprA:
3.4
1e7aA-3vprA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atg TAF6

(Antonospora
locustae)
PF07571
(TAF6_C)
5 LEU A 319
ILE A 318
VAL A 255
GLY A 311
ALA A 270
None
1.07A 1e7aA-4atgA:
2.1
1e7aA-4atgA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyl EFF-1A

(Caenorhabditis
elegans)
PF14884
(EFF-AFF)
5 LEU A 465
ILE A 388
VAL A 438
GLY A 414
ALA A 412
None
1.00A 1e7aA-4cylA:
undetectable
1e7aA-4cylA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ


(Thermobifida
fusca)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 LEU A 258
ILE A 308
LEU A 124
GLY A 127
ALA A 221
None
1.25A 1e7aA-4e6eA:
undetectable
1e7aA-4e6eA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ILE A 220
LEU A 281
ARG A 279
VAL A 234
ALA A 164
None
None
EDO  A 409 ( 3.7A)
None
None
1.21A 1e7aA-4ej6A:
undetectable
1e7aA-4ej6A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI


(Staphylococcus
aureus)
PF13561
(adh_short_C2)
5 LEU A 208
ILE A 207
ASN A 205
VAL A 201
GLY A 202
None
0WE  A 302 ( 4.8A)
None
0WE  A 302 ( 4.4A)
None
1.04A 1e7aA-4fs3A:
undetectable
1e7aA-4fs3A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7a ETHANOLAMINE
UTILIZATION PROTEIN
EUTN/CARBOXYSOME
STRUCTURAL PROTEIN
CCML


(Rhodospirillum
rubrum)
PF03319
(EutN_CcmL)
5 ILE A  81
LEU A  30
VAL A   6
GLY A  52
ALA A  49
None
1.14A 1e7aA-4i7aA:
undetectable
1e7aA-4i7aA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM


(Rattus
norvegicus)
PF00149
(Metallophos)
PF13499
(EF-hand_7)
5 LEU A 542
ILE A 545
VAL A 531
GLY A 534
ALA A 521
None
1.19A 1e7aA-4il1A:
2.4
1e7aA-4il1A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE


(Flavobacterium
johnsoniae)
PF01884
(PcrB)
5 LEU A 191
ILE A 194
VAL A 228
GLY A 208
ALA A 225
None
None
None
1GP  A 301 (-3.4A)
None
1.03A 1e7aA-4jejA:
undetectable
1e7aA-4jejA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]


(Synechocystis
sp. PCC 6803)
PF02347
(GDC-P)
5 LEU A 432
LEU A 393
VAL A 413
GLY A 412
ALA A 418
None
1.10A 1e7aA-4lglA:
undetectable
1e7aA-4lglA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6i NUCLEOPROTEIN

(Lymphocytic
choriomeningitis
mammarenavirus)
PF17290
(Arena_ncap_C)
5 LEU A 544
ILE A 543
ASN A 542
LEU A 520
GLY A 401
None
1.04A 1e7aA-4o6iA:
undetectable
1e7aA-4o6iA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN


([Ruminococcus]
gnavus)
no annotation 5 LEU E 167
ILE E 164
ASN E 163
VAL E 156
GLY E 158
None
None
PLP  E 501 ( 4.4A)
None
PLP  E 501 ( 4.3A)
1.27A 1e7aA-4obuE:
undetectable
1e7aA-4obuE:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
6 LEU A 387
ASN A 391
LEU A 407
ARG A 410
VAL A 433
GLY A 434
NPS  A 601 ( 4.7A)
NPS  A 601 (-4.3A)
NPS  A 601 ( 4.9A)
NPS  A 601 (-4.5A)
None
None
0.53A 1e7aA-4po0A:
47.8
1e7aA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnh MOTILITY REGULATOR

(Pseudomonas
aeruginosa)
PF00563
(EAL)
PF00990
(GGDEF)
5 LEU A1267
ILE A1266
LEU A1279
GLY A1221
ALA A1226
None
1.20A 1e7aA-4rnhA:
undetectable
1e7aA-4rnhA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ


(Bacillus
subtilis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 LEU A 261
ILE A 311
LEU A 127
GLY A 130
ALA A 224
None
1.28A 1e7aA-4u39A:
undetectable
1e7aA-4u39A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT
PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT


(Desulfovibrio
vulgaris)
PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
5 LEU L  57
LEU L  61
GLY S 119
CYH S 114
ALA S 130
None
None
None
SF4  S2001 (-2.2A)
None
1.30A 1e7aA-4u9iL:
undetectable
1e7aA-4u9iL:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE


(Shigella sonnei)
PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase)
5 LEU A 531
ILE A 532
LEU A 462
VAL A 551
ALA A 525
None
1.21A 1e7aA-4umvA:
undetectable
1e7aA-4umvA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN


(Ruegeria
pomeroyi)
PF00884
(Sulfatase)
PF16347
(DUF4976)
5 LEU A 403
ILE A 400
ARG A 364
VAL A   0
ALA A 384
None
1.01A 1e7aA-4uplA:
undetectable
1e7aA-4uplA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5k ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL


(Trypanosoma
brucei)
PF00155
(Aminotran_1_2)
5 LEU A 316
ILE A 332
LEU A 352
GLY A 343
ALA A 340
None
None
None
EDO  A 502 (-3.5A)
None
1.00A 1e7aA-4w5kA:
undetectable
1e7aA-4w5kA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxp NS3-4 PROTEASE

(Hepacivirus C)
PF07652
(Flavi_DEAD)
5 LEU A 226
ILE A 287
LEU A 274
GLY A 304
ALA A 310
None
1.13A 1e7aA-4wxpA:
undetectable
1e7aA-4wxpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2


(Vibrio cholerae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 LEU A 261
ILE A 257
LEU A 117
GLY A 312
ALA A 223
None
None
None
SCY  A 113 ( 3.1A)
None
1.26A 1e7aA-4x0oA:
undetectable
1e7aA-4x0oA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0w YEAZ

(Pseudomonas
aeruginosa)
PF00814
(Peptidase_M22)
5 LEU A   5
ILE A  60
LEU A  40
GLY A  77
ALA A  83
None
1.21A 1e7aA-4y0wA:
undetectable
1e7aA-4y0wA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5


(Homo sapiens)
PF00307
(CH)
5 LEU A 199
ILE A 200
VAL A 234
GLY A 233
ALA A 229
None
1.29A 1e7aA-4z6gA:
undetectable
1e7aA-4z6gA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1


(Homo sapiens)
PF12859
(ANAPC1)
5 LEU A1307
LEU A1612
VAL A1255
GLY A1256
ALA A1301
None
1.19A 1e7aA-5a31A:
2.6
1e7aA-5a31A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6s ENDOLYSIN

(Clostridium
phage phiCTP1)
PF01183
(Glyco_hydro_25)
5 ASN A 224
LEU A 250
VAL A 239
GLY A 240
ALA A 210
None
1.29A 1e7aA-5a6sA:
undetectable
1e7aA-5a6sA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE


(Mycolicibacterium
smegmatis)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ILE A 161
LEU A 250
VAL A 247
GLY A 203
ALA A 103
None
1.10A 1e7aA-5bp1A:
undetectable
1e7aA-5bp1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A  55
ILE A  54
LEU A  39
VAL A 267
ALA A 100
None
1.21A 1e7aA-5bz4A:
undetectable
1e7aA-5bz4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx8 LIPOPROTEIN RAGB

(Porphyromonas
gingivalis)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
5 LEU A 386
ILE A 387
LEU A 265
VAL A 260
ALA A 256
None
1.31A 1e7aA-5cx8A:
undetectable
1e7aA-5cx8A:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
6 LEU A 386
ASN A 390
LEU A 406
ARG A 409
VAL A 432
GLY A 433
None
0.76A 1e7aA-5dqfA:
48.6
1e7aA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 LEU A 547
ASN A 404
VAL A 423
GLY A 426
ALA A 529
None
None
PG4  A 604 ( 4.9A)
None
None
1.16A 1e7aA-5dqfA:
48.6
1e7aA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9s SERINE--PYRUVATE
AMINOTRANSFERASE


(Homo sapiens)
PF00266
(Aminotran_5)
5 LEU A  76
ILE A 220
LEU A 272
GLY A 206
ALA A  85
None
1.31A 1e7aA-5f9sA:
undetectable
1e7aA-5f9sA:
20.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
6 LEU A 387
ASN A 391
LEU A 407
ARG A 410
VAL A 433
GLY A 434
None
0.61A 1e7aA-5ghkA:
45.6
1e7aA-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
6 LEU A 387
ASN A 391
LEU A 407
VAL A 433
GLY A 434
ALA A 449
None
0.48A 1e7aA-5ghkA:
45.6
1e7aA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB


(Escherichia
coli)
PF00072
(Response_reg)
5 LEU A  23
ILE A  19
LEU A 123
VAL A 107
ALA A 112
None
0.99A 1e7aA-5i4cA:
undetectable
1e7aA-5i4cA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4q CONTACT-DEPENDENT
INHIBITOR A


(Escherichia
coli)
no annotation 5 LEU A 235
LEU A 195
ARG A 200
VAL A 246
GLY A 247
None
1.10A 1e7aA-5i4qA:
undetectable
1e7aA-5i4qA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7n MAOC-LIKE
DEHYDRATASE


(Mycobacteroides
abscessus)
PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N)
5 LEU A 266
ILE A 302
VAL A 294
GLY A 299
ALA A 292
None
0.97A 1e7aA-5i7nA:
undetectable
1e7aA-5i7nA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1


(Homo sapiens)
PF12859
(ANAPC1)
5 LEU A1307
LEU A1612
VAL A1255
GLY A1256
ALA A1301
None
1.14A 1e7aA-5lcwA:
2.7
1e7aA-5lcwA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mn5 CELL DIVISION
PROTEIN FTSZ


(Staphylococcus
aureus)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 LEU A 261
ILE A 311
LEU A 127
GLY A 130
ALA A 224
None
1.25A 1e7aA-5mn5A:
undetectable
1e7aA-5mn5A:
18.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 5 ASN A 390
LEU A 406
ARG A 409
VAL A 432
GLY A 433
None
0.79A 1e7aA-5oriA:
48.1
1e7aA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 6 LEU A 386
ILE A 387
ASN A 390
LEU A 406
VAL A 432
GLY A 433
None
0.83A 1e7aA-5oriA:
48.1
1e7aA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szm PCDHGA8 OR
PROTOCADHERIN GAMMA
A8


(Mus musculus)
PF00028
(Cadherin)
PF08266
(Cadherin_2)
5 LEU A  48
ILE A  37
LEU A  23
VAL A  90
GLY A  89
None
1.29A 1e7aA-5szmA:
undetectable
1e7aA-5szmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE


(Cupriavidus
necator)
PF07167
(PhaC_N)
5 ILE A 293
LEU A 345
VAL A 243
GLY A 321
ALA A 297
None
1.28A 1e7aA-5t6oA:
undetectable
1e7aA-5t6oA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium)
PF01341
(Glyco_hydro_6)
5 LEU A 130
ILE A 163
LEU A 143
VAL A 253
ALA A 211
None
1.26A 1e7aA-5xcyA:
undetectable
1e7aA-5xcyA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 7 LEU A 387
ASN A 391
LEU A 407
ARG A 410
VAL A 433
GLY A 434
ALA A 449
None
0.79A 1e7aA-5yxeA:
47.4
1e7aA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3y DENN
DOMAIN-CONTAINING
PROTEIN 3


(Mus musculus)
no annotation 5 LEU A 827
LEU A 807
VAL A 811
GLY A 818
ALA A 877
None
1.18A 1e7aA-6b3yA:
undetectable
1e7aA-6b3yA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2


(Candidatus
Methanoperedens
nitroreducens)
no annotation 5 LEU A  12
ILE A  15
VAL A  50
GLY A  24
ALA A  48
None
0.97A 1e7aA-6bxnA:
undetectable
1e7aA-6bxnA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1


(Homo sapiens)
no annotation 5 LEU A  76
LEU A 700
ARG A 698
GLY A 142
ALA A 139
None
1.24A 1e7aA-6c9dA:
undetectable
1e7aA-6c9dA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A


(Danio rerio)
no annotation 5 LEU A  74
ILE A  78
VAL A 112
GLY A 110
ALA A 103
None
1.11A 1e7aA-6g1kA:
3.6
1e7aA-6g1kA:
8.74