SIMILAR PATTERNS OF AMINO ACIDS FOR 1E73_M_ASCM995_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cen CELLULASE CELC

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 GLN A 140
TYR A 200
PHE A 203
PHE A 320
 BGC  A 351 (-2.8A)
BGC  A 351 (-4.3A)
None
BGC  A 351 ( 4.2A)
 0.95A 1e73M-1cenA:
20.7		 1e73M-1cenA:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		6 GLN M 187
ILE M 257
ARG M 259
TYR M 330
PHE M 331
PHE M 473
 GOL  M 936 (-3.6A)
None
SO4  M 926 ( 2.9A)
None
None
None
 0.08A 1e73M-1dwaM:
70.6		 1e73M-1dwaM:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 ILE A 220
ARG A 219
TYR A 212
PHE A 556
 None
 1.38A 1e73M-1e1cA:
2.9		 1e73M-1e1cA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		4 ILE A 257
ARG A 270
TYR A 150
PHE A 314
 None
 1.39A 1e73M-1gm5A:
0.0		 1e73M-1gm5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1

(Homo sapiens) 		no annotation 4 ILE B1952
ARG B1811
PHE B1816
PHE B1869
 None
 1.28A 1e73M-1gzhB:
undetectable		 1e73M-1gzhB:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 ILE A 547
ARG A 634
TYR A 548
PHE A 510
 None
 1.22A 1e73M-1hn0A:
undetectable		 1e73M-1hn0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk6 COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR

(Homo sapiens) 		PF00386
(C1q) 		4 ILE B 113
TYR B 145
PHE B 215
PHE B 170
 None
 1.27A 1e73M-1pk6B:
undetectable		 1e73M-1pk6B:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q32 TYROSYL-DNA
PHOSPHODIESTERASE

(Saccharomyces
cerevisiae) 		PF06087
(Tyr-DNA_phospho) 		4 ILE A 253
ARG A 116
PHE A 189
PHE A 262
 None
 1.45A 1e73M-1q32A:
undetectable		 1e73M-1q32A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urd MALTOSE-BINDING
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01547
(SBP_bac_1) 		4 GLN A 141
ILE A 288
PHE A  73
PHE A 180
 MLR  A1400 (-3.1A)
None
MLR  A1400 (-4.6A)
None
 1.14A 1e73M-1urdA:
0.0		 1e73M-1urdA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		4 ILE A 127
ARG A 171
PHE A 134
PHE A  64
 None
 1.46A 1e73M-1vjzA:
19.9		 1e73M-1vjzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A 418
ARG A 419
TYR A 422
PHE A 436
 None
 1.38A 1e73M-1w93A:
undetectable		 1e73M-1w93A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		4 GLN A 414
ILE A 446
TYR A 439
PHE A 435
 None
 1.36A 1e73M-1wacA:
undetectable		 1e73M-1wacA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xd5 ANTIFUNGAL PROTEIN
GAFP-1

(Gastrodia elata) 		PF01453
(B_lectin) 		4 GLN A  88
ILE A  86
ARG A   3
TYR A  96
 None
 1.31A 1e73M-1xd5A:
undetectable		 1e73M-1xd5A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xd6 GASTRODIANIN-4

(Gastrodia elata) 		PF01453
(B_lectin) 		4 GLN A  88
ILE A  86
ARG A   3
TYR A  96
 None
 1.32A 1e73M-1xd6A:
undetectable		 1e73M-1xd6A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 GLN A  61
ILE A  12
ARG A 183
PHE A  97
 None
 1.41A 1e73M-1yirA:
3.5		 1e73M-1yirA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		4 GLN A 122
ILE A 184
PHE A 239
PHE A 189
 None
 1.32A 1e73M-2ocpA:
undetectable		 1e73M-2ocpA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q03 UNCHARACTERIZED
PROTEIN

(Shewanella
denitrificans) 		PF11528
(DUF3224) 		4 GLN A  40
ILE A  38
PHE A  66
PHE A 100
 None
 1.50A 1e73M-2q03A:
undetectable		 1e73M-2q03A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7a CELL SURFACE
HEME-BINDING PROTEIN

(Streptococcus
pyogenes) 		PF11545
(HemeBinding_Shp) 		4 ILE A  51
ARG A  44
TYR A 160
PHE A 112
 None
 1.45A 1e73M-2q7aA:
undetectable		 1e73M-2q7aA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqz GLYOXALASE FAMILY
PROTEIN, PUTATIVE

(Bacillus
anthracis) 		PF00903
(Glyoxalase) 		4 ILE A  31
TYR A  27
PHE A  50
PHE A 112
 None
 1.16A 1e73M-2qqzA:
undetectable		 1e73M-2qqzA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9k UNCHARACTERIZED
PROTEIN FLJ32312

(Homo sapiens) 		no annotation 4 ILE A 189
ARG A  23
TYR A 186
PHE A 214
 None
 1.37A 1e73M-2v9kA:
undetectable		 1e73M-2v9kA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ILE B 278
TYR B 276
PHE B 291
PHE B 166
 None
 1.15A 1e73M-2w55B:
undetectable		 1e73M-2w55B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR) 		4 ILE A 300
ARG A 299
TYR A  67
PHE A  82
 None
 1.49A 1e73M-2xrcA:
undetectable		 1e73M-2xrcA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		4 GLN A1003
ILE A 926
PHE A 459
PHE A1011
 None
 1.39A 1e73M-3aibA:
3.5		 1e73M-3aibA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLN A 515
ILE A 511
ARG A 507
TYR A 508
 None
 1.33A 1e73M-3gdnA:
undetectable		 1e73M-3gdnA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 ILE A 503
ARG A 758
TYR A 498
PHE A 711
 None
 1.47A 1e73M-3jbhA:
undetectable		 1e73M-3jbhA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkv UNCHARACTERIZED
CONSERVED DOMAIN
PROTEIN

(Vibrio cholerae) 		PF04392
(ABC_sub_bind) 		4 GLN A  34
ILE A  95
TYR A  67
PHE A  65
 None
 1.10A 1e73M-3lkvA:
undetectable		 1e73M-3lkvA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 ILE A1014
ARG A1016
TYR A 996
PHE A 558
 None
 1.45A 1e73M-3nafA:
undetectable		 1e73M-3nafA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npi TETR FAMILY
REGULATORY PROTEIN

(Corynebacterium
diphtheriae) 		PF00440
(TetR_N) 		4 ILE A 176
ARG A 175
TYR A 105
PHE A 102
 None
 1.46A 1e73M-3npiA:
undetectable		 1e73M-3npiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr5 REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION MAF1
HOMOLOG

(Homo sapiens) 		PF09174
(Maf1) 		4 ILE A  50
TYR A 121
PHE A 142
PHE A 130
 None
 1.21A 1e73M-3nr5A:
undetectable		 1e73M-3nr5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohw PHYCOBILISOME LCM
CORE-MEMBRANE LINKER
POLYPEPTIDE

(Synechocystis
sp. PCC 6803) 		no annotation 4 ILE B 755
TYR B 743
PHE B 747
PHE B 777
 None
 1.33A 1e73M-3ohwB:
undetectable		 1e73M-3ohwB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1

(Saccharomyces
cerevisiae) 		PF06087
(Tyr-DNA_phospho) 		4 ILE A 253
ARG A 116
PHE A 189
PHE A 262
 None
 1.49A 1e73M-3sq7A:
undetectable		 1e73M-3sq7A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts9 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 ILE A  80
TYR A  83
PHE A  10
PHE A 121
 None
 1.38A 1e73M-3ts9A:
undetectable		 1e73M-3ts9A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 GLN A 175
ILE A 181
TYR A 224
PHE A 235
 None
 1.12A 1e73M-3umtA:
undetectable		 1e73M-3umtA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
HEME SUBUNIT

(Thermochromatium
tepidum) 		no annotation 4 GLN A  43
ILE A  49
ARG A 141
PHE A 136
 HEC  A 202 ( 4.6A)
None
HEC  A 202 ( 3.0A)
HEC  A 202 (-4.5A)
 1.21A 1e73M-3vrdA:
undetectable		 1e73M-3vrdA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzh PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pyogenes) 		PF09704
(Cas_Cas5d) 		4 ILE A  63
ARG A  10
TYR A  95
PHE A  18
 None
 1.32A 1e73M-3vzhA:
undetectable		 1e73M-3vzhA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ILE A 831
ARG A 829
TYR A 679
PHE A 611
 None
 1.08A 1e73M-3zyvA:
undetectable		 1e73M-3zyvA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Sus scrofa) 		PF00271
(Helicase_C) 		4 ILE A 619
TYR A 622
PHE A 549
PHE A 677
 None
 1.47A 1e73M-4i1sA:
undetectable		 1e73M-4i1sA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE

(Staphylococcus
aureus) 		PF02423
(OCD_Mu_crystall) 		4 GLN A 154
ILE A 235
PHE A 231
PHE A 162
 None
 1.37A 1e73M-4mp3A:
undetectable		 1e73M-4mp3A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9f CORE-BINDING FACTOR
SUBUNIT BETA
VIRION INFECTIVITY
FACTOR

(Homo sapiens;
Human
immunodeficiency
virus 1) 		no annotation
no annotation 		4 GLN b  97
ILE b   9
PHE a  17
PHE a 143
 None
 1.40A 1e73M-4n9fb:
undetectable		 1e73M-4n9fb:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqe MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS
I-RELATED GENE
PROTEIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ILE A  96
ARG A   9
TYR A   7
PHE A 168
 2L4  A 301 (-4.0A)
2L4  A 301 (-3.5A)
2L4  A 301 (-3.7A)
None
 1.46A 1e73M-4nqeA:
undetectable		 1e73M-4nqeA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntb LEUKOTRIENE C4
SYNTHASE

(Mus musculus) 		PF01124
(MAPEG) 		4 ILE A  27
ARG A  30
PHE A  46
PHE A  94
 None
 1.40A 1e73M-4ntbA:
undetectable		 1e73M-4ntbA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 ARG A 292
TYR A 200
PHE A 289
PHE A 219
 None
 1.45A 1e73M-4xh9A:
undetectable		 1e73M-4xh9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001) 		PF01425
(Amidase) 		4 ILE A 360
TYR A 136
PHE A 138
PHE A  87
 None
 0.98A 1e73M-4yjiA:
undetectable		 1e73M-4yjiA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8s RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00161
(RIP) 		4 ARG A  77
TYR A  76
PHE A  97
PHE A 151
 None
 1.27A 1e73M-4z8sA:
undetectable		 1e73M-4z8sA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE

(Thymus vulgaris) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ILE A 204
ARG A 161
PHE A 157
PHE A 183
 ILE  A 204 ( 0.7A)
ARG  A 161 (-0.6A)
PHE  A 157 ( 1.3A)
PHE  A 183 ( 1.3A)
 1.07A 1e73M-5c05A:
undetectable		 1e73M-5c05A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h82 HETEROYOHIMBINE
SYNTHASE THAS2

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 152
ARG A  30
TYR A  12
PHE A  28
 None
 0.98A 1e73M-5h82A:
1.3		 1e73M-5h82A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		4 ILE A 297
TYR A 329
PHE A 399
PHE A 354
 None
 1.29A 1e73M-5hkjA:
undetectable		 1e73M-5hkjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 GLN A1454
ARG A1367
TYR A1525
PHE A1340
 None
 1.32A 1e73M-5i6hA:
undetectable		 1e73M-5i6hA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		4 GLN A 880
TYR A 878
PHE A 839
PHE A 809
 None
 0.98A 1e73M-5j7tA:
undetectable		 1e73M-5j7tA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk7 PROTEIN VPRBP

(Homo sapiens) 		no annotation 4 ILE C1083
ARG C1081
TYR C1387
PHE C1334
 None
 1.49A 1e73M-5jk7C:
undetectable		 1e73M-5jk7C:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3h POLYMERASE ACIDIC
PROTEIN

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 ILE A  54
ARG A  75
TYR A 112
PHE A  76
 None
 1.33A 1e73M-5m3hA:
undetectable		 1e73M-5m3hA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqo NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bacteroides
thetaiotaomicron) 		PF07944
(Glyco_hydro_127) 		4 ILE A 330
TYR A 304
PHE A 391
PHE A 287
 None
 1.02A 1e73M-5mqoA:
undetectable		 1e73M-5mqoA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
BETA

(Chaetomium
thermophilum) 		PF01602
(Adaptin_N) 		4 ILE A  61
TYR A  81
PHE A  97
PHE A 122
 None
 1.46A 1e73M-5mu7A:
undetectable		 1e73M-5mu7A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o32 COMPLEMENT FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00530
(SRCR) 		4 ILE D 318
ARG D 317
TYR D  85
PHE D 100
 None
NAG  D 403 (-4.7A)
None
None
 1.42A 1e73M-5o32D:
undetectable		 1e73M-5o32D:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td6 FOG-3 PROTEIN

(Caenorhabditis
elegans) 		PF07742
(BTG) 		4 ILE A  89
ARG A 100
PHE A  98
PHE A  40
 None
 1.22A 1e73M-5td6A:
undetectable		 1e73M-5td6A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tta PUTATIVE EXPORTED
PROTEIN

(Clostridioides
difficile) 		no annotation 4 GLN A 210
ILE A 204
TYR A 101
PHE A 214
 None
 1.47A 1e73M-5ttaA:
undetectable		 1e73M-5ttaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF13401
(AAA_22)
PF14630
(ORC5_C) 		4 ILE E 333
TYR E 473
PHE E 474
PHE E 350
 None
 1.29A 1e73M-5v8fE:
undetectable		 1e73M-5v8fE:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens;
Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 ILE A 327
ARG A 325
TYR A 322
PHE B  88
 None
 1.46A 1e73M-5y3rA:
undetectable		 1e73M-5y3rA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 4 GLN I 145
ARG I 487
PHE I 483
PHE I 209
 None
 1.42A 1e73M-6bnpI:
undetectable		 1e73M-6bnpI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 4 GLN A 302
ARG A 214
PHE A 210
PHE A 161
 None
 1.11A 1e73M-6bxnA:
undetectable		 1e73M-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 4 GLN A 211
ARG A 184
PHE A 229
PHE A 355
 None
 1.42A 1e73M-6cc2A:
undetectable		 1e73M-6cc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 4 ILE A1120
ARG A1187
PHE A 266
PHE A1085
 None
 1.17A 1e73M-6fn1A:
undetectable		 1e73M-6fn1A:
undetectable