SIMILAR PATTERNS OF AMINO ACIDS FOR 1DZM_B_BZMB600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a3y ODORANT BINDING
PROTEIN

(Sus scrofa) 		PF00061
(Lipocalin) 		9 ILE A  21
MET A  39
VAL A  80
TYR A  82
ASN A  86
ASN A 102
MET A 114
GLY A 116
LEU A 118
 None
 0.39A 1dzmB-1a3yA:
29.1		 1dzmB-1a3yA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a3y ODORANT BINDING
PROTEIN

(Sus scrofa) 		PF00061
(Lipocalin) 		5 ILE A  29
TYR A  82
ASN A  86
ASN A 102
MET A 114
 None
 1.26A 1dzmB-1a3yA:
29.1		 1dzmB-1a3yA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		5 ILE A 442
VAL A 381
ASN A 411
GLY A 441
LEU A 433
 None
 1.14A 1dzmB-1gq2A:
0.0		 1dzmB-1gq2A:
15.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1obp ODORANT-BINDING
PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 ILE A  22
TYR A  83
ASN A  87
ASN A 103
GLY A 117
 UNX  A 186 (-3.9A)
UNX  A 167 ( 4.6A)
UNX  A 197 (-3.7A)
UNX  A 198 ( 2.8A)
UNX  A 181 (-2.9A)
 0.49A 1dzmB-1obpA:
18.6		 1dzmB-1obpA:
43.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Thermus
thermophilus) 		PF02219
(MTHFR) 		5 ILE A 178
VAL A 100
ASN A 102
GLY A 146
LEU A 106
 FAD  A 300 (-3.7A)
None
None
None
FAD  A 300 (-4.0A)
 1.13A 1dzmB-1v93A:
0.0		 1dzmB-1v93A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		5 ILE A 226
VAL A 416
ASN A 420
ASN A 238
GLY A 434
 None
 1.38A 1dzmB-1w8jA:
0.0		 1dzmB-1w8jA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 ILE A 226
VAL A 416
ASN A 420
ASN A 238
GLY A 434
 None
 1.31A 1dzmB-2dfsA:
0.0		 1dzmB-2dfsA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 134
MET A 257
ASN A 146
GLY A 297
LEU A 293
 None
 1.14A 1dzmB-2hlpA:
0.0		 1dzmB-2hlpA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 134
MET A 257
VAL A 142
ASN A 146
LEU A 293
 None
 1.31A 1dzmB-2hlpA:
0.0		 1dzmB-2hlpA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mou STAR-RELATED LIPID
TRANSFER PROTEIN 6

(Homo sapiens) 		PF01852
(START) 		5 ILE A 144
VAL A 171
ASN A 148
GLY A 177
LEU A 179
 None
 1.27A 1dzmB-2mouA:
0.0		 1dzmB-2mouA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 5 ILE A 282
VAL A 330
ASN A 239
ASN A 170
LEU A 323
 None
 1.20A 1dzmB-3j4uA:
0.0		 1dzmB-3j4uA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 ILE A 260
MET A 239
ASN A 253
GLY A 258
LEU A 268
 None
 1.41A 1dzmB-3rblA:
undetectable		 1dzmB-3rblA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		5 VAL A  95
ASN A  88
ASN A 508
MET A 371
GLY A 506
 None
 1.37A 1dzmB-3ujhA:
undetectable		 1dzmB-3ujhA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jro FABG PROTEIN

(Listeria
monocytogenes) 		PF13561
(adh_short_C2) 		5 ILE A 163
VAL A 110
TYR A 155
ASN A 114
GLY A 164
 None
 1.37A 1dzmB-4jroA:
undetectable		 1dzmB-4jroA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kry ACETYL ESTERASE

(Escherichia
coli) 		PF07859
(Abhydrolase_3) 		5 ILE A 159
VAL A  65
MET A 156
GLY A 186
LEU A 178
 None
 1.31A 1dzmB-4kryA:
undetectable		 1dzmB-4kryA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ILE A 452
MET A 328
VAL A 598
ASN A 497
LEU A 332
 None
None
None
GOL  A 705 ( 4.8A)
None
 1.49A 1dzmB-4ye5A:
undetectable		 1dzmB-4ye5A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6c URIC ACID-XANTHINE
PERMEASE

(Aspergillus
nidulans) 		PF00860
(Xan_ur_permease) 		5 ILE A 131
VAL A 367
ASN A 410
ASN A 409
GLY A 424
 None
 1.25A 1dzmB-5i6cA:
undetectable		 1dzmB-5i6cA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 5 ILE A 336
MET A  67
VAL A 356
ASN A 333
GLY A 335
 None
 1.47A 1dzmB-5m6gA:
undetectable		 1dzmB-5m6gA:
16.73