SIMILAR PATTERNS OF AMINO ACIDS FOR 1DZ8_B_CAMB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 135
GLY A 134
THR A 131
VAL A 129
ASP A 141
 None
 1.39A 1dz8B-1d6hA:
undetectable		 1dz8B-1d6hA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu3 EIF4GII

(Homo sapiens) 		PF02854
(MIF4G) 		5 THR A 751
VAL A 791
GLY A 790
VAL A 821
ASP A 783
 None
 1.13A 1dz8B-1hu3A:
0.0		 1dz8B-1hu3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juh QUERCETIN
2,3-DIOXYGENASE

(Aspergillus
japonicus) 		no annotation 5 PHE A 136
TYR A  35
THR A  53
GLY A  62
THR A 113
 EDO  A2028 (-4.7A)
EDO  A2028 (-4.6A)
EDO  A2028 (-3.1A)
None
None
 1.38A 1dz8B-1juhA:
0.0		 1dz8B-1juhA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		5 TYR A1181
LEU A1103
VAL A1063
GLY A 997
THR A1161
 None
 1.35A 1dz8B-1k7yA:
undetectable		 1dz8B-1k7yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 TYR A 561
THR A 559
VAL A 520
GLY A 519
THR A 552
 None
None
None
None
GOL  A1823 (-4.3A)
 1.43A 1dz8B-1kb0A:
undetectable		 1dz8B-1kb0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lmi IMMUNOGENIC PROTEIN
MPT63/MPB63

(Mycobacterium
tuberculosis) 		PF09167
(DUF1942) 		5 TYR A   3
LEU A 127
GLY A  25
VAL A  22
ASP A  17
 None
 1.42A 1dz8B-1lmiA:
0.0		 1dz8B-1lmiA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		5 PHE A 285
TYR A 616
THR A 166
LEU A 170
GLY A 639
 None
 1.46A 1dz8B-1mqsA:
0.0		 1dz8B-1mqsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE

(Escherichia
coli) 		PF02965
(Met_synt_B12) 		5 TYR A1181
LEU A1103
VAL A1063
GLY A 997
THR A1161
 None
 1.31A 1dz8B-1mskA:
0.0		 1dz8B-1mskA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 LEU D 192
GLY D  70
THR D  74
VAL D  46
ASP D  43
 None
AGS  D 804 (-3.0A)
None
None
None
 1.15A 1dz8B-1sxjD:
0.0		 1dz8B-1sxjD:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN

(Shigella
flexneri) 		PF02578
(Cu-oxidase_4) 		5 PHE A 112
LEU A 130
VAL A 134
GLY A 133
VAL A 205
 None
 1.22A 1dz8B-1u05A:
undetectable		 1dz8B-1u05A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		5 PHE A 236
THR A 263
LEU A 303
VAL A 307
VAL A 244
 None
 1.41A 1dz8B-1vbmA:
undetectable		 1dz8B-1vbmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 242
THR A 252
LEU A 335
VAL A 341
GLY A 330
 None
 1.50A 1dz8B-1xapA:
undetectable		 1dz8B-1xapA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		5 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.50A 1dz8B-2fi1A:
undetectable		 1dz8B-2fi1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 THR A 252
LEU A 193
VAL A 390
GLY A 391
VAL A 398
 None
 1.12A 1dz8B-2i6tA:
undetectable		 1dz8B-2i6tA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 PHE A 535
TYR A 478
THR A 114
GLY A 357
VAL A 527
 None
 1.44A 1dz8B-2jirA:
undetectable		 1dz8B-2jirA:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		6 PHE A  87
TYR A  96
LEU A 244
GLY A 248
THR A 252
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
None
 1.28A 1dz8B-2m56A:
68.3		 1dz8B-2m56A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		9 PHE A  87
TYR A  96
THR A 101
LEU A 244
VAL A 247
GLY A 248
THR A 252
VAL A 295
ASP A 297
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
 0.60A 1dz8B-2m56A:
68.3		 1dz8B-2m56A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2k METHIONINE SYNTHASE

(Homo sapiens) 		PF02965
(Met_synt_B12) 		5 TYR A1219
LEU A1141
VAL A1102
GLY A1030
THR A1199
 None
 1.29A 1dz8B-2o2kA:
undetectable		 1dz8B-2o2kA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 PHE A 161
THR A 231
GLY A 453
THR A 438
VAL A 289
 GOL  A 602 (-4.0A)
NAD  A 500 (-4.1A)
None
None
GOL  A 602 ( 4.6A)
 1.39A 1dz8B-3b4wA:
undetectable		 1dz8B-3b4wA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bex TYPE III
PANTOTHENATE KINASE

(Thermotoga
maritima) 		PF03309
(Pan_kinase) 		5 THR A 235
VAL A  62
GLY A   8
THR A  10
ASP A 125
 None
PAU  A 248 ( 4.4A)
PO4  A 247 (-3.5A)
PO4  A 247 (-3.6A)
None
 1.39A 1dz8B-3bexA:
undetectable		 1dz8B-3bexA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		5 TYR A 165
THR A 216
VAL A 121
GLY A 122
THR A 137
 None
 1.04A 1dz8B-3emyA:
undetectable		 1dz8B-3emyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq1 PORPHOBILINOGEN
DEAMINASE

(Homo sapiens) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		5 PHE A  51
THR A  41
LEU A 238
VAL A 235
GLY A 236
 None
 1.37A 1dz8B-3eq1A:
undetectable		 1dz8B-3eq1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		5 PHE A 155
TYR A  84
THR A 102
GLY A  44
VAL A 131
 None
 1.49A 1dz8B-3ik2A:
undetectable		 1dz8B-3ik2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Hahella
chejuensis) 		PF13407
(Peripla_BP_4) 		5 PHE A 187
THR A 231
LEU A 229
GLY A 254
THR A 159
 None
 1.31A 1dz8B-3ksmA:
undetectable		 1dz8B-3ksmA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		5 THR A 229
LEU A 325
VAL A 245
GLY A 326
VAL A 283
 None
 1.38A 1dz8B-3lpdA:
undetectable		 1dz8B-3lpdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		5 PHE A 401
LEU A 478
VAL A 447
THR A 149
VAL A 495
 None
 1.48A 1dz8B-3p27A:
undetectable		 1dz8B-3p27A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		5 LEU A 191
VAL A 137
GLY A 193
THR A 195
ASP A 150
 None
None
None
None
ACT  A 402 (-4.0A)
 1.12A 1dz8B-3qphA:
undetectable		 1dz8B-3qphA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfz CYCLASE

(Streptomyces
sp. R1128) 		PF10604
(Polyketide_cyc2) 		5 THR A  34
VAL A  24
GLY A  26
VAL A 150
ASP A 146
 None
None
None
None
CXS  A 171 (-4.7A)
 1.33A 1dz8B-3tfzA:
undetectable		 1dz8B-3tfzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		5 THR A 229
LEU A 325
VAL A 245
GLY A 326
VAL A 283
 None
 1.42A 1dz8B-3ti7A:
undetectable		 1dz8B-3ti7A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpu 42F3 ALPHA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		5 TYR A  38
LEU A  46
VAL A  59
GLY A  58
ASP A  84
 None
 1.44A 1dz8B-3tpuA:
undetectable		 1dz8B-3tpuA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyj BCLA PROTEIN

(Bacillus
anthracis) 		no annotation 5 THR A 142
LEU A 198
VAL A 193
GLY A 150
VAL A 138
 None
 1.48A 1dz8B-3tyjA:
undetectable		 1dz8B-3tyjA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3v E1 ENVELOPE
GLYCOPROTEIN

(Rubella virus) 		PF05748
(Rubella_E1) 		5 PHE A 102
TYR A 109
THR A  55
GLY A  94
VAL A 138
 None
None
PEG  A1449 ( 4.2A)
PEG  A1449 ( 3.4A)
CA  A1451 ( 4.6A)
 1.25A 1dz8B-4b3vA:
undetectable		 1dz8B-4b3vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx0 PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 THR A 172
LEU A 118
VAL A 112
GLY A 114
VAL A 196
 None
 1.47A 1dz8B-4bx0A:
undetectable		 1dz8B-4bx0A:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		7 TYR A  98
THR A 103
LEU A 252
GLY A 256
THR A 260
VAL A 303
ASP A 305
 None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
 0.66A 1dz8B-4c9mA:
58.9		 1dz8B-4c9mA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		6 TYR A  98
THR A 103
LEU A 252
GLY A 256
THR A 260
VAL A 404
 None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.5A)
 1.14A 1dz8B-4c9mA:
58.9		 1dz8B-4c9mA:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw1 MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
GLYCOPROTEIN
HAPLOTYPE B14

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 TYR A  58
VAL A  34
GLY A  26
THR A  24
VAL A  66
 None
 1.13A 1dz8B-4cw1A:
undetectable		 1dz8B-4cw1A:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 PHE A  87
LEU A 250
GLY A 254
THR A 258
VAL A 301
 None
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
 0.63A 1dz8B-4dxyA:
52.3		 1dz8B-4dxyA:
46.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 THR A 101
LEU A 250
GLY A 254
THR A 258
VAL A 301
 HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
 0.81A 1dz8B-4dxyA:
52.3		 1dz8B-4dxyA:
46.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc4 NITRITE TRANSPORTER
NIRC

(Salmonella
enterica) 		PF01226
(Form_Nir_trans) 		5 PHE A 190
THR A  81
LEU A  79
VAL A  38
THR A 203
 None
 1.42A 1dz8B-4fc4A:
undetectable		 1dz8B-4fc4A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 PHE A 321
THR A 433
LEU A 434
VAL A 340
GLY A 341
 None
 1.27A 1dz8B-4ksiA:
undetectable		 1dz8B-4ksiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvs ALDEHYDE
DECARBONYLASE

(Prochlorococcus
marinus) 		PF11266
(Ald_deCOase) 		5 TYR A  30
LEU A  87
VAL A  89
GLY A  84
VAL A  41
 None
None
None
None
6NA  A 301 ( 4.2A)
 1.25A 1dz8B-4kvsA:
undetectable		 1dz8B-4kvsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 PHE A1162
THR A1169
GLY A1121
THR A1456
VAL A1142
 None
 1.30A 1dz8B-4ll6A:
undetectable		 1dz8B-4ll6A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 788
VAL A 792
THR A 778
VAL A 743
ASP A 803
 None
None
TPO  A 780 ( 2.6A)
None
None
 1.46A 1dz8B-4otdA:
undetectable		 1dz8B-4otdA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovx XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

(Planctopirus
limnophila) 		PF01261
(AP_endonuc_2) 		5 TYR A 267
THR A 301
LEU A 305
VAL A 283
GLY A 284
 None
 1.36A 1dz8B-4ovxA:
undetectable		 1dz8B-4ovxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxw PROTOCADHERIN-15

(Mus musculus) 		no annotation 5 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.38A 1dz8B-4xxwB:
undetectable		 1dz8B-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5s ALDEHYDE
DECARBONYLASE

(Synechocystis
sp. PCC 6803) 		PF11266
(Ald_deCOase) 		5 TYR A  17
LEU A  74
VAL A  76
GLY A  71
VAL A  28
 None
 1.34A 1dz8B-4z5sA:
undetectable		 1dz8B-4z5sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		5 PHE K 873
LEU K 887
VAL K 890
GLY K 889
THR K 763
 None
 1.38A 1dz8B-5anbK:
undetectable		 1dz8B-5anbK:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		5 PHE A 354
THR A 465
LEU A 466
VAL A 372
GLY A 373
 None
 1.33A 1dz8B-5cbmA:
undetectable		 1dz8B-5cbmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 2

(Homo sapiens) 		PF00169
(PH) 		5 THR A 553
LEU A 479
VAL A 493
GLY A 477
VAL A 565
 None
 1.32A 1dz8B-5efxA:
undetectable		 1dz8B-5efxA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		5 TYR A  17
LEU A  74
VAL A  76
GLY A  71
VAL A  28
 None
None
None
None
OCD  A 500 ( 4.6A)
 1.27A 1dz8B-5k52A:
undetectable		 1dz8B-5k52A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k53 ALDEHYDE
DEFORMYLATING
OXYGENASE

(Oscillatoria
sp.) 		PF11266
(Ald_deCOase) 		5 TYR A  17
LEU A  74
VAL A  76
GLY A  71
VAL A  28
 None
None
None
None
STE  A 502 ( 4.8A)
 1.18A 1dz8B-5k53A:
undetectable		 1dz8B-5k53A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 PHE A 402
THR A  79
LEU A  69
GLY A 188
THR A 135
 None
 1.49A 1dz8B-5tvjA:
undetectable		 1dz8B-5tvjA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 5 THR A 295
LEU A  20
VAL A  18
GLY A 169
ASP A 302
 None
 1.26A 1dz8B-5wgcA:
undetectable		 1dz8B-5wgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 5 THR A 295
LEU A  20
VAL A  18
GLY A 169
THR A 145
 None
 1.11A 1dz8B-5wgcA:
undetectable		 1dz8B-5wgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE

(Geobacillus sp.
12AMOR1) 		no annotation 5 PHE A 245
LEU A  39
VAL A  25
GLY A  95
THR A 103
 None
 1.27A 1dz8B-5xksA:
undetectable		 1dz8B-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14

(Saccharomyces
cerevisiae) 		PF00782
(DSPc)
PF14671
(DSPn) 		5 PHE A 185
THR A 301
VAL A 266
GLY A 267
ASP A 184
 None
 1.47A 1dz8B-5xw5A:
undetectable		 1dz8B-5xw5A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 5 PHE A 428
THR A 501
VAL A 243
GLY A 301
VAL A 384
 None
 1.15A 1dz8B-6d35A:
undetectable		 1dz8B-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 PHE A  34
TYR A  30
THR A 213
LEU A 274
VAL A 325
 None
 1.41A 1dz8B-6eu6A:
undetectable		 1dz8B-6eu6A:
undetectable