SIMILAR PATTERNS OF AMINO ACIDS FOR 1DZ6_B_CAMB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		4 PHE D 200
VAL D 353
VAL D 192
ASP D 194
 None
 1.37A 1dz6B-1dkgD:
0.0		 1dz6B-1dkgD:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4v HISTIDYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 PHE B 228
TYR B 175
VAL B 182
ASP B 227
 None
 1.06A 1dz6B-1h4vB:
0.0		 1dz6B-1h4vB:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		4 PHE A  94
VAL A 107
VAL A  52
ASP A  65
 None
None
None
CA  A   7 (-2.2A)
 1.11A 1dz6B-1ktwA:
0.0		 1dz6B-1ktwA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		4 PHE A  94
VAL A 111
VAL A  52
ASP A  65
 None
None
None
CA  A   7 (-2.2A)
 1.14A 1dz6B-1ktwA:
0.0		 1dz6B-1ktwA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 TYR A 443
VAL A 544
VAL A 509
ASP A 487
 None
 1.43A 1dz6B-1llaA:
0.0		 1dz6B-1llaA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofm CHONDROITINASE B

(Pedobacter
heparinus) 		PF14592
(Chondroitinas_B) 		4 PHE A 237
TYR A 261
VAL A 232
VAL A 470
 None
 1.43A 1dz6B-1ofmA:
0.0		 1dz6B-1ofmA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9c GLUTATHIONE
TRANSFERASE

(Mesorhizobium
loti) 		PF00903
(Glyoxalase) 		4 PHE A 117
VAL A  54
VAL A  12
ASP A 111
 None
 1.40A 1dz6B-1r9cA:
0.0		 1dz6B-1r9cA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 TYR A 465
VAL A 335
VAL A 355
ASP A 352
 None
 1.38A 1dz6B-1w6sA:
0.0		 1dz6B-1w6sA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xau B- AND T-LYMPHOCYTE
ATTENUATOR

(Mus musculus) 		PF13895
(Ig_2) 		4 PHE A  82
VAL A 109
VAL A 113
ASP A  89
 None
 1.37A 1dz6B-1xauA:
undetectable		 1dz6B-1xauA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycd HYPOTHETICAL 27.3
KDA PROTEIN IN
AAP1-SMF2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF03959
(FSH1) 		4 PHE A  10
TYR A  41
VAL A 220
VAL A 231
 None
 1.22A 1dz6B-1ycdA:
0.0		 1dz6B-1ycdA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 TYR A  16
VAL A  53
VAL A  42
ASP A  10
 None
None
None
MG  A 500 (-2.8A)
 1.35A 1dz6B-1ydfA:
undetectable		 1dz6B-1ydfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys9 PROTEIN SPY1043

(Streptococcus
pyogenes) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 TYR A  15
VAL A  52
VAL A  41
ASP A   9
 None
 1.44A 1dz6B-1ys9A:
undetectable		 1dz6B-1ys9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv9 HYDROLASE, HALOACID
DEHALOGENASE FAMILY

(Enterococcus
faecalis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 TYR A  17
VAL A  54
VAL A  43
ASP A  11
 None
None
None
PO4  A3001 (-3.0A)
 1.45A 1dz6B-1yv9A:
undetectable		 1dz6B-1yv9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0y PROCATHEPSIN S

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 PHE A 289
TYR A 247
VAL A 281
VAL A 115
 None
 1.47A 1dz6B-2c0yA:
undetectable		 1dz6B-2c0yA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9i GREEN FLUORESCENT
PROTEIN ASFP499

(Anemonia
sulcata) 		PF01353
(GFP) 		4 PHE A  80
TYR A 178
VAL A 147
VAL A 214
 None
 1.08A 1dz6B-2c9iA:
undetectable		 1dz6B-2c9iA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.09A 1dz6B-2ct8A:
undetectable		 1dz6B-2ct8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		4 PHE A  77
TYR A  78
VAL A 148
VAL A 197
 None
 1.22A 1dz6B-2h0aA:
undetectable		 1dz6B-2h0aA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ill TITIN

(Homo sapiens) 		PF07679
(I-set) 		4 PHE A 162
TYR A 149
VAL A 193
ASP A 170
 None
 1.48A 1dz6B-2illA:
undetectable		 1dz6B-2illA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae) 		no annotation 4 PHE B 458
VAL B 482
VAL B 462
ASP B 460
 None
 1.23A 1dz6B-2j04B:
undetectable		 1dz6B-2j04B:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 PHE A  87
TYR A  96
VAL A 247
VAL A 295
ASP A 297
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
None
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
 0.23A 1dz6B-2m56A:
68.1		 1dz6B-2m56A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mt6 UBIQUITIN-CONJUGATIN
G ENZYME E2 W

(Homo sapiens) 		PF00179
(UQ_con) 		4 PHE A  60
TYR A  64
VAL A 108
VAL A  39
 None
 1.34A 1dz6B-2mt6A:
undetectable		 1dz6B-2mt6A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozz HYPOTHETICAL PROTEIN
YHFZ

(Shigella
flexneri) 		PF14503
(YhfZ_C) 		4 PHE A  43
TYR A  45
VAL A  67
VAL A 207
 None
 1.20A 1dz6B-2ozzA:
undetectable		 1dz6B-2ozzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozz HYPOTHETICAL PROTEIN
YHFZ

(Shigella
flexneri) 		PF14503
(YhfZ_C) 		4 PHE A  43
TYR A  45
VAL A 190
VAL A 206
 None
 1.26A 1dz6B-2ozzA:
undetectable		 1dz6B-2ozzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkq GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
B

(Spinacia
oleracea) 		PF00044
(Gp_dh_N)
PF02672
(CP12)
PF02800
(Gp_dh_C) 		4 PHE O   8
VAL O  57
VAL O  73
ASP O  32
 None
None
None
NDP  O 363 ( 4.8A)
 1.34A 1dz6B-2pkqO:
undetectable		 1dz6B-2pkqO:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		4 TYR A 663
VAL A 755
VAL A 785
ASP A 745
 None
 1.49A 1dz6B-2yhbA:
undetectable		 1dz6B-2yhbA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
agalactiae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 TYR A  17
VAL A  54
VAL A  43
ASP A  11
 None
None
None
NA  A 266 (-2.7A)
 1.46A 1dz6B-3eprA:
undetectable		 1dz6B-3eprA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grn MUTT RELATED PROTEIN

(Methanosarcina
mazei) 		PF00293
(NUDIX) 		4 PHE A 126
TYR A  12
VAL A  85
ASP A  39
 None
 1.34A 1dz6B-3grnA:
undetectable		 1dz6B-3grnA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1c DIISOPROPYL-FLUOROPH
OSPHATASE

(Loligo vulgaris) 		PF08450
(SGL) 		4 PHE A 124
TYR A 305
VAL A  96
ASP A  79
 None
 1.46A 1dz6B-3i1cA:
undetectable		 1dz6B-3i1cA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzt UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF12883
(DUF3828) 		4 PHE A  58
TYR A  62
VAL A  93
VAL A 149
 None
 1.24A 1dz6B-3kztA:
undetectable		 1dz6B-3kztA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00102
(Y_phosphatase) 		4 PHE A 106
TYR A 135
VAL A 189
VAL A  93
 None
 1.31A 1dz6B-3m4uA:
undetectable		 1dz6B-3m4uA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF04073
(tRNA_edit)
PF08668
(HDOD) 		4 PHE A 140
VAL A  35
VAL A 104
ASP A 101
 None
 1.45A 1dz6B-3memA:
undetectable		 1dz6B-3memA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pov ORF 37

(Human
gammaherpesvirus
8) 		PF01771
(Herpes_alk_exo) 		4 PHE A 408
TYR A 251
VAL A 289
VAL A 342
 None
 1.30A 1dz6B-3povA:
undetectable		 1dz6B-3povA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Salmonella
enterica) 		PF00290
(Trp_syntA) 		4 PHE A 114
TYR A 115
VAL A 123
VAL A  52
 None
 1.41A 1dz6B-3pr2A:
undetectable		 1dz6B-3pr2A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzl AGMATINE
UREOHYDROLASE

(Thermoplasma
volcanium) 		PF00491
(Arginase) 		4 PHE A 268
VAL A 254
VAL A 271
ASP A 269
 None
 1.34A 1dz6B-3pzlA:
undetectable		 1dz6B-3pzlA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3i NUCLEOCAPSID PROTEIN

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 PHE A 392
TYR A 311
VAL A 319
VAL A 397
 None
 1.36A 1dz6B-3u3iA:
undetectable		 1dz6B-3u3iA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A  31
TYR A  36
VAL A  43
VAL A  76
 None
 1.48A 1dz6B-3wd8A:
undetectable		 1dz6B-3wd8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bru ATP-DEPENDENT RNA
HELICASE DHH1

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 PHE A 100
VAL A 133
VAL A 121
ASP A 195
 None
 1.25A 1dz6B-4bruA:
undetectable		 1dz6B-4bruA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bru ATP-DEPENDENT RNA
HELICASE DHH1

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.07A 1dz6B-4bruA:
undetectable		 1dz6B-4bruA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxj KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF00651
(BTB) 		4 PHE A 107
TYR A 162
VAL A  83
VAL A  79
 None
 1.35A 1dz6B-4cxjA:
undetectable		 1dz6B-4cxjA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo0 ACTIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF00022
(Actin) 		4 TYR A 240
VAL A 263
VAL A 268
ASP A 238
 None
 1.49A 1dz6B-4fo0A:
undetectable		 1dz6B-4fo0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphaerobacter
thermophilus) 		PF00903
(Glyoxalase) 		4 PHE A 125
VAL A  60
VAL A  18
ASP A 119
 None
 1.33A 1dz6B-4hc5A:
undetectable		 1dz6B-4hc5A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqz UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF16253
(DUF4909) 		4 PHE A  79
TYR A 100
VAL A  72
ASP A  70
 None
 1.20A 1dz6B-4lqzA:
undetectable		 1dz6B-4lqzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9i SERPIN-18

(Bombyx mori) 		PF00079
(Serpin) 		4 PHE A 246
TYR A 202
VAL A 295
VAL A 377
 None
BME  A 403 (-4.8A)
BME  A 403 ( 4.6A)
None
 1.41A 1dz6B-4r9iA:
undetectable		 1dz6B-4r9iA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4std SCYTALONE
DEHYDRATASE

(Magnaporthe
grisea) 		PF02982
(Scytalone_dh) 		4 PHE A  53
TYR A  50
VAL A  75
VAL A 108
 None
BFS  A 173 (-4.3A)
BFS  A 173 (-4.5A)
BFS  A 173 ( 4.4A)
 1.02A 1dz6B-4stdA:
undetectable		 1dz6B-4stdA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 PHE L 128
TYR L 129
VAL L 137
VAL L 279
 None
 1.31A 1dz6B-4u9iL:
undetectable		 1dz6B-4u9iL:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxw PROTOCADHERIN-15

(Mus musculus) 		no annotation 4 PHE B 183
TYR B 207
VAL B 135
VAL B 141
 None
 1.41A 1dz6B-4xxwB:
undetectable		 1dz6B-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		4 PHE A 163
TYR A 202
VAL A 151
VAL A 117
 None
 0.94A 1dz6B-4y96A:
undetectable		 1dz6B-4y96A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 PHE A  54
TYR A  55
VAL A 176
VAL A 254
 GOL  A 401 (-3.6A)
GOL  A 401 ( 4.5A)
None
None
 1.41A 1dz6B-4yv7A:
undetectable		 1dz6B-4yv7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgs PUTATIVE D-LACTATE
DEHYDROGENASE

(Chlamydomonas
reinhardtii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 PHE A 338
TYR A 134
VAL A  86
VAL A  46
 NAD  A1000 (-3.6A)
NAD  A1000 (-4.0A)
None
None
 1.17A 1dz6B-4zgsA:
undetectable		 1dz6B-4zgsA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 PHE A 655
TYR A 656
VAL A 276
VAL A 175
 None
 1.32A 1dz6B-5f7sA:
undetectable		 1dz6B-5f7sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9x BETA-1,3-GLUCANASE

(Paenibacillus
barengoltzii) 		PF16483
(Glyco_hydro_64) 		4 TYR A 371
VAL A 357
VAL A 400
ASP A 398
 None
 1.33A 1dz6B-5h9xA:
undetectable		 1dz6B-5h9xA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 PHE A  34
TYR A  16
VAL A  28
VAL A  75
 None
 1.46A 1dz6B-5i1wA:
undetectable		 1dz6B-5i1wA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 4 PHE A 382
TYR A 465
VAL A 712
ASP A 388
 None
 1.23A 1dz6B-5o7eA:
undetectable		 1dz6B-5o7eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 PHE A 796
VAL A 766
VAL A 690
ASP A 795
 None
 1.43A 1dz6B-5t8vA:
undetectable		 1dz6B-5t8vA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa2 SURFACE ANTIGEN

(Toxoplasma
gondii) 		no annotation 4 PHE A 166
TYR A 149
VAL A 182
VAL A 198
 None
 1.41A 1dz6B-5wa2A:
undetectable		 1dz6B-5wa2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Homo sapiens) 		PF01370
(Epimerase) 		4 PHE J  64
VAL J 243
VAL J 352
ASP J 211
 None
None
None
NDP  J 401 ( 4.0A)
 1.24A 1dz6B-5xtdJ:
undetectable		 1dz6B-5xtdJ:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu6 CBM32 DOMAIN

(Vibrio) 		no annotation 4 PHE A 108
VAL A  80
VAL A 138
ASP A  60
 None
 1.47A 1dz6B-5zu6A:
undetectable		 1dz6B-5zu6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 4 PHE A 559
TYR A 440
VAL A 363
ASP A 557
 None
 1.45A 1dz6B-6em0A:
undetectable		 1dz6B-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 PHE A 330
VAL A 341
VAL A 333
ASP A 331
 None
 1.19A 1dz6B-6en4A:
undetectable		 1dz6B-6en4A:
undetectable