SIMILAR PATTERNS OF AMINO ACIDS FOR 1DZ6_A_CAMA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		4 PHE A 217
TYR A 218
LEU A 260
ASP A 190
 None
 1.15A 1dz6A-1lc7A:
0.0		 1dz6A-1lc7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 PHE A 462
TYR A 466
LEU A 430
VAL A 367
 None
 1.40A 1dz6A-1ldjA:
0.0		 1dz6A-1ldjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lmi IMMUNOGENIC PROTEIN
MPT63/MPB63

(Mycobacterium
tuberculosis) 		PF09167
(DUF1942) 		4 TYR A   3
LEU A 127
VAL A  22
ASP A  17
 None
 1.49A 1dz6A-1lmiA:
undetectable		 1dz6A-1lmiA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n71 AAC(6')-II

(Enterococcus
faecium) 		PF00583
(Acetyltransf_1) 		4 PHE A 146
TYR A 147
LEU A  73
VAL A  78
 COA  A 601 (-3.7A)
None
None
COA  A 601 (-4.1A)
 1.23A 1dz6A-1n71A:
0.0		 1dz6A-1n71A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1
SEROTRANSFERRIN,
C-LOBE

(Homo sapiens;
Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
PF00405
(Transferrin) 		4 TYR A 643
LEU A 639
VAL E 360
ASP E 356
 None
 1.49A 1dz6A-1suvA:
0.0		 1dz6A-1suvA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 PHE B 224
TYR B 176
LEU B 232
VAL B 340
 None
 1.44A 1dz6A-1tnuB:
0.0		 1dz6A-1tnuB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wk4 TTK003001606

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		4 PHE A 139
TYR A 140
LEU A  91
VAL A  96
 MES  A 201 ( 4.3A)
None
None
MES  A 201 ( 4.4A)
 1.20A 1dz6A-1wk4A:
0.0		 1dz6A-1wk4A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 PHE A 563
TYR A 631
LEU A 547
VAL A 560
 None
 1.34A 1dz6A-2a3lA:
0.0		 1dz6A-2a3lA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae6 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		4 PHE A 129
TYR A 130
LEU A  82
VAL A  86
 None
 1.34A 1dz6A-2ae6A:
undetectable		 1dz6A-2ae6A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 PHE A 205
TYR A 181
LEU A  35
VAL A  50
 None
 1.18A 1dz6A-2bg9A:
undetectable		 1dz6A-2bg9A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgk GLUTAMATE
DECARBOXYLASE BETA

(Escherichia
coli) 		PF00282
(Pyridoxal_deC) 		4 PHE A 380
TYR A 363
LEU A 360
VAL A 406
 None
 1.22A 1dz6A-2dgkA:
undetectable		 1dz6A-2dgkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edk MYOSIN-BINDING
PROTEIN C, FAST-TYPE

(Homo sapiens) 		PF07679
(I-set) 		4 PHE A  71
TYR A  58
LEU A  48
ASP A  78
 None
 1.22A 1dz6A-2edkA:
undetectable		 1dz6A-2edkA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fna CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF01637
(ATPase_2) 		4 PHE A 228
TYR A 252
VAL A 233
ASP A 230
 None
 1.38A 1dz6A-2fnaA:
undetectable		 1dz6A-2fnaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 PHE A 239
TYR A 275
LEU A 103
ASP A 268
 None
 1.24A 1dz6A-2hgsA:
undetectable		 1dz6A-2hgsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Saccharomyces
cerevisiae) 		PF03770
(IPK) 		4 PHE A 326
TYR A  41
LEU A 117
ASP A 325
 None
 1.47A 1dz6A-2iewA:
undetectable		 1dz6A-2iewA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k6v PUTATIVE CYTOCHROME
C OXIDASE ASSEMBLY
PROTEIN

(Thermus
thermophilus) 		PF02630
(SCO1-SenC) 		4 TYR A  93
LEU A  55
VAL A  80
ASP A  85
 None
 1.47A 1dz6A-2k6vA:
undetectable		 1dz6A-2k6vA:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 PHE A  87
TYR A  96
LEU A 244
VAL A 295
ASP A 297
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
 0.19A 1dz6A-2m56A:
69.3		 1dz6A-2m56A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 PHE A  87
TYR A  96
LEU A 244
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
None
 0.68A 1dz6A-2m56A:
69.3		 1dz6A-2m56A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozz HYPOTHETICAL PROTEIN
YHFZ

(Shigella
flexneri) 		PF14503
(YhfZ_C) 		4 PHE A  43
TYR A  45
LEU A  30
VAL A 207
 None
 1.47A 1dz6A-2ozzA:
undetectable		 1dz6A-2ozzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2
HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF09454
(Vps23_core)
PF07200
(Mod_r)
PF09452
(Mvb12) 		4 PHE D  71
TYR D  75
LEU C  58
VAL A 232
 None
 1.24A 1dz6A-2p22D:
undetectable		 1dz6A-2p22D:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		4 PHE A 271
LEU A 218
VAL A 264
ASP A 222
 None
None
None
ANP  A 600 ( 4.6A)
 1.34A 1dz6A-2qptA:
undetectable		 1dz6A-2qptA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5u REPLICATIVE DNA
HELICASE

(Mycobacterium
tuberculosis) 		PF00772
(DnaB) 		4 PHE A  57
TYR A  66
LEU A  49
ASP A  56
 None
 1.33A 1dz6A-2r5uA:
undetectable		 1dz6A-2r5uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy4 SINGLE DOMAIN
HAEMOGLOBIN

(Campylobacter
jejuni) 		PF00042
(Globin) 		4 PHE A  42
TYR A  28
LEU A  56
VAL A  89
 HEM  A 150 ( 3.5A)
CYN  A 151 (-4.7A)
CYN  A 151 (-4.1A)
HEM  A 150 (-3.8A)
 1.11A 1dz6A-2wy4A:
undetectable		 1dz6A-2wy4A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xot AMPHOTERIN-INDUCED
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF13855
(LRR_8) 		4 PHE A 247
TYR A 217
LEU A 189
ASP A 246
 None
 1.34A 1dz6A-2xotA:
undetectable		 1dz6A-2xotA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE

(Bacillus
subtilis) 		no annotation 4 PHE A 162
TYR A  32
LEU A  42
ASP A 160
 None
 1.22A 1dz6A-2y0oA:
undetectable		 1dz6A-2y0oA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etu PROTEIN TRANSPORT
PROTEIN DSL1

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		4 PHE A 179
TYR A 167
LEU A 123
VAL A  68
 None
 1.20A 1dz6A-3etuA:
undetectable		 1dz6A-3etuA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etv PROTEIN TRANSPORT
PROTEIN TIP20,
PROTEIN TRANSPORT
PROTEIN DSL1 CHIMERA

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		4 PHE A 191
TYR A 179
LEU A 135
VAL A  80
 None
 1.31A 1dz6A-3etvA:
undetectable		 1dz6A-3etvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		4 PHE A   3
LEU A 282
VAL A 360
ASP A  33
 None
 1.39A 1dz6A-3fdbA:
undetectable		 1dz6A-3fdbA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD

(Ruegeria
pomeroyi) 		PF12680
(SnoaL_2) 		4 PHE A  75
LEU A 114
VAL A  12
ASP A  88
 UNL  A 137 ( 4.4A)
None
UNL  A 137 (-4.7A)
UNL  A 137 (-2.7A)
 1.47A 1dz6A-3fljA:
undetectable		 1dz6A-3fljA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp7 HEMOLYSIN, PUTATIVE

(Streptococcus
thermophilus) 		PF01479
(S4)
PF01728
(FtsJ) 		4 PHE A  77
LEU A 181
VAL A 261
ASP A 227
 None
 1.15A 1dz6A-3hp7A:
undetectable		 1dz6A-3hp7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0u PHOSPHOTHREONINE
LYASE OSPF

(Shigella
flexneri) 		PF03536
(VRP3) 		4 PHE A  51
TYR A  49
LEU A 169
ASP A 127
 None
 1.25A 1dz6A-3i0uA:
undetectable		 1dz6A-3i0uA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1c DIISOPROPYL-FLUOROPH
OSPHATASE

(Loligo vulgaris) 		PF08450
(SGL) 		4 PHE A 124
TYR A 305
VAL A  96
ASP A  79
 None
 1.48A 1dz6A-3i1cA:
undetectable		 1dz6A-3i1cA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		4 PHE A 105
TYR A 447
LEU A 425
VAL A 512
 None
 1.07A 1dz6A-3j1cA:
undetectable		 1dz6A-3j1cA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbm TETR TRANSCRIPTIONAL
REGULATOR

(Chloroflexus
aurantiacus) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 PHE A  19
TYR A  24
LEU A 119
VAL A  12
 None
None
PGE  A 210 ( 4.9A)
None
 1.42A 1dz6A-3qbmA:
undetectable		 1dz6A-3qbmA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 PHE A 646
TYR A 674
LEU A 676
VAL A 608
 None
 1.38A 1dz6A-3qfsA:
undetectable		 1dz6A-3qfsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		4 TYR A 224
LEU A  47
VAL A 169
ASP A  28
 None
 1.47A 1dz6A-3rv6A:
undetectable		 1dz6A-3rv6A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		4 PHE A 586
LEU A 590
VAL A 444
ASP A 441
 None
 0.89A 1dz6A-3t6gA:
undetectable		 1dz6A-3t6gA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Francisella
tularensis) 		PF01380
(SIS) 		4 PHE A 574
TYR A 436
LEU A 428
ASP A 573
 None
 1.32A 1dz6A-3tbfA:
undetectable		 1dz6A-3tbfA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		4 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.06A 1dz6A-3ubcA:
undetectable		 1dz6A-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8h THYMIDYLATE SYNTHASE

(Burkholderia
thailandensis) 		PF00303
(Thymidylat_synt) 		4 PHE A 306
LEU A  63
VAL A 284
ASP A 305
 None
 1.27A 1dz6A-3v8hA:
undetectable		 1dz6A-3v8hA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 PHE A 219
TYR A 241
LEU A 199
VAL A 185
 None
 1.30A 1dz6A-3zppA:
undetectable		 1dz6A-3zppA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqq L2 PROTEIN III
(PENTON BASE)

(Human
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		4 TYR A 376
LEU A 478
VAL A 210
ASP A 214
 None
 1.40A 1dz6A-4aqqA:
undetectable		 1dz6A-4aqqA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 PHE A 205
TYR A 181
LEU A  35
VAL A  50
 None
 1.17A 1dz6A-4booA:
undetectable		 1dz6A-4booA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 PHE A1985
LEU A2026
VAL A1907
ASP A1977
 None
 1.33A 1dz6A-4c0dA:
undetectable		 1dz6A-4c0dA:
19.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 TYR A  98
LEU A 252
VAL A 303
ASP A 305
 None
HEM  A1418 (-4.0A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
 0.57A 1dz6A-4c9mA:
57.8		 1dz6A-4c9mA:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6q PROLINE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF01619
(Pro_dh) 		4 TYR A 288
LEU A 257
VAL A 164
ASP A 135
 TFB  A2002 (-4.7A)
FAD  A2001 (-3.8A)
FAD  A2001 (-4.1A)
TFB  A2002 ( 3.7A)
 1.38A 1dz6A-4h6qA:
undetectable		 1dz6A-4h6qA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6k AMIDOHYDROLASE
FAMILY PROTEIN

(Acinetobacter
baumannii) 		PF04909
(Amidohydro_2) 		4 PHE A 152
TYR A 150
LEU A 112
VAL A 100
 None
 1.35A 1dz6A-4i6kA:
undetectable		 1dz6A-4i6kA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		4 PHE A 301
TYR A 351
LEU A 364
ASP A 292
 None
 1.43A 1dz6A-4iggA:
undetectable		 1dz6A-4iggA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 PHE A3640
TYR A3638
LEU A3551
ASP A3126
 None
 1.22A 1dz6A-4kc5A:
undetectable		 1dz6A-4kc5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 PHE A3708
LEU A3915
VAL A3893
ASP A3876
 None
 1.45A 1dz6A-4kc5A:
undetectable		 1dz6A-4kc5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 PHE A 268
TYR A 293
LEU A 283
VAL A 264
 None
 1.45A 1dz6A-4kcaA:
undetectable		 1dz6A-4kcaA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7a UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF15890
(Peptidase_Mx1) 		4 PHE A  65
TYR A  57
LEU A 100
VAL A 144
 None
 1.43A 1dz6A-4l7aA:
undetectable		 1dz6A-4l7aA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 TYR A 300
LEU A 287
VAL A 529
ASP A 526
 None
 1.49A 1dz6A-4lq1A:
undetectable		 1dz6A-4lq1A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqz UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF16253
(DUF4909) 		4 PHE A  79
TYR A 100
VAL A  72
ASP A  70
 None
 1.20A 1dz6A-4lqzA:
undetectable		 1dz6A-4lqzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8a BIFUNCTIONAL PROTEIN
PUTA

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 TYR A 552
LEU A 513
VAL A 402
ASP A 370
 2OP  A2002 (-4.7A)
FAD  A2001 (-4.2A)
FAD  A2001 (-4.4A)
FAD  A2001 ( 3.7A)
 1.30A 1dz6A-4o8aA:
undetectable		 1dz6A-4o8aA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN

(Pyrococcus
horikoshii) 		PF00375
(SDF) 		4 TYR A  88
LEU A 250
VAL A 400
ASP A 312
 None
 1.23A 1dz6A-4oyeA:
undetectable		 1dz6A-4oyeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 PHE A 303
TYR A 311
LEU A 322
VAL A 379
 None
 1.44A 1dz6A-4s15A:
undetectable		 1dz6A-4s15A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u13 PUTATIVE POLYKETIDE
CYCLASE SMA1630

(Sinorhizobium
meliloti) 		PF12680
(SnoaL_2) 		4 PHE A  11
TYR A  10
LEU A 103
VAL A  78
 None
 1.26A 1dz6A-4u13A:
undetectable		 1dz6A-4u13A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuu IMMUNOGLOBULIN HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE E  29
TYR E  27
LEU E   4
VAL E  51
 None
 1.45A 1dz6A-4wuuE:
undetectable		 1dz6A-4wuuE:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		4 TYR A 517
LEU A 225
VAL A 706
ASP A 666
 None
 1.45A 1dz6A-4xprA:
undetectable		 1dz6A-4xprA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxw PROTOCADHERIN-15

(Mus musculus) 		no annotation 4 PHE B 183
TYR B 207
LEU B 234
VAL B 141
 None
 1.42A 1dz6A-4xxwB:
undetectable		 1dz6A-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2g CARBOXYLIC ESTER
HYDROLASE

(Hungatella
hathewayi) 		PF00135
(COesterase) 		4 PHE A 360
TYR A 364
LEU A 401
ASP A 371
 None
 1.38A 1dz6A-5a2gA:
undetectable		 1dz6A-5a2gA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 PHE A 327
TYR A 347
LEU A 368
VAL A 393
 None
 1.38A 1dz6A-5fq6A:
undetectable		 1dz6A-5fq6A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 PHE A1985
LEU A2026
VAL A1907
ASP A1977
 None
 1.38A 1dz6A-5fu7A:
undetectable		 1dz6A-5fu7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 TYR A 329
LEU A 316
VAL A 558
ASP A 555
 None
 1.49A 1dz6A-5gr1A:
undetectable		 1dz6A-5gr1A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gte LACHRYMATORY-FACTOR
SYNTHASE

(Allium cepa) 		PF10604
(Polyketide_cyc2) 		4 PHE A 104
TYR A 114
LEU A 152
VAL A  73
 None
 0.90A 1dz6A-5gteA:
undetectable		 1dz6A-5gteA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 TYR A 485
LEU A 449
VAL A 338
ASP A 306
 TFB  A2003 (-4.9A)
FAD  A2001 (-4.1A)
FAD  A2001 (-4.3A)
TFB  A2003 ( 3.5A)
 1.29A 1dz6A-5kf7A:
undetectable		 1dz6A-5kf7A:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgd PLATELET
GLYCOPROTEIN 4

(Homo sapiens) 		PF01130
(CD36) 		4 PHE A 122
TYR A  93
LEU A 179
VAL A 128
 None
 1.40A 1dz6A-5lgdA:
undetectable		 1dz6A-5lgdA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt9 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTB

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 PHE A  99
LEU A 117
VAL A 153
ASP A 173
 ARG  A 301 (-3.6A)
ARG  A 301 (-4.7A)
None
ARG  A 301 (-3.1A)
 1.21A 1dz6A-5lt9A:
undetectable		 1dz6A-5lt9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL

(Homo sapiens) 		PF01180
(DHO_dh) 		4 PHE A  98
LEU A  68
VAL A 116
ASP A  99
 None
U91  A 403 (-4.8A)
None
None
 1.26A 1dz6A-5mvdA:
undetectable		 1dz6A-5mvdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 4 PHE A 382
TYR A 465
VAL A 712
ASP A 388
 None
 1.27A 1dz6A-5o7eA:
undetectable		 1dz6A-5o7eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Mus musculus;
Gloeobacter
violaceus) 		no annotation 4 PHE A 164
TYR A 185
LEU A 129
VAL A  38
 None
 1.49A 1dz6A-5osbA:
undetectable		 1dz6A-5osbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcb PELA

(Pseudomonas
aeruginosa) 		PF03537
(Glyco_hydro_114) 		4 TYR A 282
LEU A 246
VAL A 234
ASP A 260
 None
 1.36A 1dz6A-5tcbA:
undetectable		 1dz6A-5tcbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9o PLASTID DIVISION
PROTEIN CDP1,
CHLOROPLASTIC,PLASTI
D DIVISION PROTEIN
PDV1

(Arabidopsis
thaliana) 		no annotation 4 PHE A 810
TYR A 798
LEU A 773
VAL A 703
 None
 1.50A 1dz6A-5u9oA:
undetectable		 1dz6A-5u9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Homo sapiens) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 PHE A 452
TYR A 197
LEU A 137
ASP A 443
 None
 1.40A 1dz6A-5ukwA:
undetectable		 1dz6A-5ukwA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 4 PHE C 165
TYR C 186
LEU C 130
VAL C  39
 None
 1.47A 1dz6A-5v6nC:
undetectable		 1dz6A-5v6nC:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeu -

(-) 		no annotation 4 PHE A 491
TYR A 511
LEU A 454
VAL A 462
 None
 1.42A 1dz6A-5yeuA:
undetectable		 1dz6A-5yeuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 4 PHE A 610
TYR A 851
LEU A 864
VAL A 743
 None
 1.49A 1dz6A-6c01A:
undetectable		 1dz6A-6c01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 4 PHE F 158
TYR F 127
LEU F  67
ASP F 216
 None
 1.37A 1dz6A-6f0kF:
undetectable		 1dz6A-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdt -

(-) 		no annotation 4 PHE A  67
TYR A  10
LEU A 482
VAL A  32
 None
 1.40A 1dz6A-6gdtA:
undetectable		 1dz6A-6gdtA:
undetectable