SIMILAR PATTERNS OF AMINO ACIDS FOR 1DY5_B_ACTB602_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 SER A 414
TYR A 412
GLN A 403
MET A 410
 None
 1.44A 1dy5B-1nfgA:
0.0		 1dy5B-1nfgA:
15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1srn RIBONUCLEASE A

(Bos taurus) 		PF00074
(RnaseA) 		4 SER A  21
TYR A  25
GLN A  28
MET A  29
 None
 0.91A 1dy5B-1srnA:
20.5		 1dy5B-1srnA:
99.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcw AROMATIC
PRENYLTRANSFERASE

(Streptomyces
sp. CL190) 		PF11468
(PTase_Orf2) 		4 SER A 214
TYR A 175
GLN A 161
MET A 162
 None
GPP  A 401 (-4.7A)
None
GPP  A 401 ( 4.7A)
 1.40A 1dy5B-1zcwA:
0.0		 1dy5B-1zcwA:
16.99