SIMILAR PATTERNS OF AMINO ACIDS FOR 1DY4_A_SNPA437
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dyp | KAPPA-CARRAGEENASE (Pseudoalteromonascarrageenovora) |
PF00722(Glyco_hydro_16) | 5 | ALA A 142TYR A 64GLU A 163ASP A 165GLU A 168 | NoneNoneNoneNone CL A1307 ( 4.3A) | 1.15A | 1dy4A-1dypA:11.1 | 1dy4A-1dypA:20.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1eg1 | ENDOGLUCANASE I (Trichodermareesei) |
PF00840(Glyco_hydro_7) | 7 | TYR A 146TYR A 170ASP A 172GLN A 174GLU A 196ASP A 198GLU A 201 | None | 0.39A | 1dy4A-1eg1A:48.7 | 1dy4A-1eg1A:43.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1eg1 | ENDOGLUCANASE I (Trichodermareesei) |
PF00840(Glyco_hydro_7) | 5 | TYR A 146TYR A 170ASP A 198GLU A 201ASP A 322 | None | 0.71A | 1dy4A-1eg1A:48.7 | 1dy4A-1eg1A:43.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h8l | CARBOXYPEPTIDASEGP180 RESIDUES503-882 (Lophonettaspecularioides) |
PF00246(Peptidase_M14)PF13620(CarboxypepD_reg) | 5 | ALA A 214TYR A 189TYR A 201ASP A 207SER A 204 | None | 1.45A | 1dy4A-1h8lA:undetectable | 1dy4A-1h8lA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n21 | (+)-BORNYLDIPHOSPHATE SYNTHASE (Salviaofficinalis) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 5 | ALA A 425TYR A 426ASP A 351GLU A 429THR A 500 | None MG A 701 ( 4.8A) MG A 703 (-2.4A) MG A 701 (-4.6A) MG A 702 ( 2.7A) | 1.24A | 1dy4A-1n21A:undetectable | 1dy4A-1n21A:19.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ovw | ENDOGLUCANASE I (Fusariumoxysporum) |
PF00840(Glyco_hydro_7) | 8 | ALA A 143TYR A 145TYR A 171ASP A 173GLN A 175GLU A 197ASP A 199GLU A 202 | DP5 A 401 (-3.6A)DP5 A 401 (-3.5A)NoneDP5 A 401 (-3.4A)DP5 A 401 (-4.2A)DP5 A 401 ( 2.5A)DP5 A 401 (-3.0A)DP5 A 401 ( 2.9A) | 0.35A | 1dy4A-1ovwA:51.3 | 1dy4A-1ovwA:39.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q2e | EXOCELLOBIOHYDROLASEI (Trichodermareesei) |
PF00840(Glyco_hydro_7) | 10 | ALA A 143TYR A 145TYR A 171ASP A 173SER A 174GLN A 175GLU A 212ASP A 214GLU A 217ASP A 369 | NoneNoneNoneNoneNoneGLC A 904 (-3.5A)NoneGLC A 904 (-3.9A)GLC A 904 (-2.9A)None | 0.30A | 1dy4A-1q2eA:70.9 | 1dy4A-1q2eA:97.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9h | CELLOBIOHYDROLASE ICATALYTIC DOMAIN (Rasamsoniaemersonii) |
PF00840(Glyco_hydro_7) | 12 | ALA A 140TYR A 142TYR A 168ASP A 170SER A 171GLN A 172GLU A 209ASP A 211GLU A 214THR A 243ARG A 248ASP A 373 | None | 0.28A | 1dy4A-1q9hA:64.4 | 1dy4A-1q9hA:66.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tkk | SIMILAR TOCHLOROMUCONATECYCLOISOMERASE (Bacillussubtilis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 307SER A 31GLU A 47THR A 51ARG A 24 | NoneNoneNoneNoneGLU A2471 (-3.8A) | 1.48A | 1dy4A-1tkkA:undetectable | 1dy4A-1tkkA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uj2 | URIDINE-CYTIDINEKINASE 2 (Homo sapiens) |
PF00485(PRK) | 5 | ALA A 139SER A 34GLU A 135ARG A 174ASP A 84 | None MG A2303 ( 2.3A) MG A2303 ( 4.6A)C5P A2301 (-3.9A)C5P A2301 (-2.8A) | 1.12A | 1dy4A-1uj2A:undetectable | 1dy4A-1uj2A:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1un1 | XYLOGLUCANENDOTRANSGLYCOSYLASE (Populus tremula) |
PF00722(Glyco_hydro_16)PF06955(XET_C) | 5 | ALA A 73TYR A 75GLU A 85ASP A 87GLU A 89 | None | 0.50A | 1dy4A-1un1A:11.4 | 1dy4A-1un1A:18.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1z3v | CELLULASE (Phanerochaetechrysosporium) |
PF00840(Glyco_hydro_7) | 10 | ALA A 140TYR A 142ASP A 170SER A 171GLN A 172GLU A 207ASP A 209GLU A 212ARG A 240ASP A 366 | NoneNoneNoneNoneLAT A 500 (-3.3A)NoneNoneLAT A 500 ( 4.5A)LAT A 500 (-3.1A)None | 0.54A | 1dy4A-1z3vA:62.2 | 1dy4A-1z3vA:55.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1z3v | CELLULASE (Phanerochaetechrysosporium) |
PF00840(Glyco_hydro_7) | 10 | ALA A 140TYR A 142TYR A 168ASP A 170SER A 171GLN A 172GLU A 207ASP A 209GLU A 212ASP A 366 | NoneNoneNoneNoneNoneLAT A 500 (-3.3A)NoneNoneLAT A 500 ( 4.5A)None | 0.24A | 1dy4A-1z3vA:62.2 | 1dy4A-1z3vA:55.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2a39 | ENDOGLUCANASE I (Humicolainsolens) |
PF00840(Glyco_hydro_7) | 9 | ALA A 145TYR A 147TYR A 171ASP A 173GLN A 175GLU A 197ASP A 199GLU A 202ASP A 349 | None | 0.53A | 1dy4A-2a39A:50.6 | 1dy4A-2a39A:40.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f37 | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 2 (Homo sapiens) |
PF12796(Ank_2) | 5 | TYR A 207ASP A 242SER A 243GLN A 244GLU A 210 | None | 1.38A | 1dy4A-2f37A:undetectable | 1dy4A-2f37A:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftp | HYDROXYMETHYLGLUTARYL-COA LYASE (Pseudomonasaeruginosa) |
PF00682(HMGL-like) | 5 | ALA A 78TYR A 44TYR A 172SER A 175GLU A 46 | None | 1.22A | 1dy4A-2ftpA:undetectable | 1dy4A-2ftpA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ixd | LMBE-RELATED PROTEIN (Bacillus cereus) |
PF02585(PIG-L) | 5 | ALA A 60SER A 177GLN A 178GLU A 56ASP A 15 | NoneNoneNoneNone ZN A1234 ( 2.1A) | 0.99A | 1dy4A-2ixdA:undetectable | 1dy4A-2ixdA:20.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rfz | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Melanocarpusalbomyces) |
PF00840(Glyco_hydro_7) | 11 | ALA A 143TYR A 145TYR A 171ASP A 173GLN A 175GLU A 212ASP A 214GLU A 217THR A 246ARG A 251ASP A 368 | CTR A 431 ( 4.6A)CTR A 431 (-3.8A)NoneCTR A 431 (-3.0A)CTR A 431 (-3.3A)CTR A 431 (-3.3A)CTR A 431 (-4.2A)CTR A 431 (-3.1A)CTR A 431 (-4.2A)CTR A 431 (-3.4A)None | 0.72A | 1dy4A-2rfzA:61.9 | 1dy4A-2rfzA:50.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2yg1 | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Heterobasidionannosum) |
PF00840(Glyco_hydro_7) | 10 | ALA A 145TYR A 147TYR A 173ASP A 175GLN A 177GLU A 214ASP A 216GLU A 219ARG A 251ASP A 377 | None | 0.26A | 1dy4A-2yg1A:61.7 | 1dy4A-2yg1A:56.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2yok | EXOGLUCANASE 1 (Trichodermaharzianum) |
PF00840(Glyco_hydro_7) | 12 | ALA A 156TYR A 158TYR A 184ASP A 186SER A 187GLN A 188GLU A 225ASP A 227GLU A 230THR A 259ARG A 264ASP A 382 | NoneNoneNoneNoneNoneNoneNoneNoneNonePEG A1445 (-3.5A)PEG A1445 (-3.3A)None | 0.48A | 1dy4A-2yokA:69.7 | 1dy4A-2yokA:82.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6e | BETA-GLUCANASE (Bacilluslicheniformis) |
PF00722(Glyco_hydro_16) | 5 | ALA A 77TYR A 79GLU A 92ASP A 94GLU A 96 | None | 0.47A | 1dy4A-3d6eA:10.7 | 1dy4A-3d6eA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwk | PENICILLIN-BINDINGPROTEIN 2 (Staphylococcusaureus) |
PF00905(Transpeptidase)PF00912(Transgly) | 5 | TYR A 210ASP A 199SER A 198ASP A 241ASP A 383 | None | 1.46A | 1dy4A-3dwkA:undetectable | 1dy4A-3dwkA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhh | OUTER MEMBRANE HEMERECEPTOR SHUA (Shigelladysenteriae) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | ALA A 221GLN A 59GLU A 191THR A 39ARG A 43 | None | 1.36A | 1dy4A-3fhhA:undetectable | 1dy4A-3fhhA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ipi | GERANYLTRANSTRANSFERASE (Methanosarcinamazei) |
PF00348(polyprenyl_synt) | 5 | ASP A 90SER A 86THR A 175ARG A 54ASP A 215 | NoneNoneNoneMLA A 305 (-4.0A)None | 1.43A | 1dy4A-3ipiA:undetectable | 1dy4A-3ipiA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l76 | ASPARTOKINASE (Synechocystissp. PCC 6803) |
PF00696(AA_kinase)PF01842(ACT)PF13840(ACT_7) | 5 | ALA A 405TYR A 266ASP A 267GLN A 270THR A 317 | None | 1.30A | 1dy4A-3l76A:undetectable | 1dy4A-3l76A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ozy | PUTATIVE MANDELATERACEMASE (Bordetellabronchiseptica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 251SER A 145ASP A 201GLU A 227ASP A 277 | NoneNone MG A 390 (-2.8A) MG A 390 (-3.1A)None | 1.34A | 1dy4A-3ozyA:undetectable | 1dy4A-3ozyA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uca | GERANYLTRANSTRANSFERASE (Clostridiumperfringens) |
PF00348(polyprenyl_synt) | 5 | ASP A 91SER A 87THR A 188ARG A 55ASP A 228 | None | 1.44A | 1dy4A-3ucaA:undetectable | 1dy4A-3ucaA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va8 | PROBABLE DEHYDRATASE (Fusariumgraminearum) |
PF13378(MR_MLE_C) | 5 | ALA A 266TYR A 243SER A 146GLU A 245ASP A 292 | NoneNoneNone MG A 425 ( 2.8A)None | 1.07A | 1dy4A-3va8A:undetectable | 1dy4A-3va8A:21.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4csi | CELLULASE (Humicola grisea) |
PF00840(Glyco_hydro_7) | 10 | ALA A 144TYR A 146TYR A 172ASP A 174GLN A 176GLU A 213ASP A 215GLU A 218ARG A 252ASP A 374 | PEG A1439 (-3.6A)PEG A1439 (-3.9A)NonePEG A1439 ( 3.9A)PEG A1439 (-3.4A)PEG A1439 (-2.8A)PEG A1439 ( 3.9A)PEG A1439 (-3.5A)NoneNone | 0.27A | 1dy4A-4csiA:64.4 | 1dy4A-4csiA:59.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dhg | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Thermobisporabispora) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 263TYR A 240SER A 143GLU A 242ASP A 289 | None | 1.08A | 1dy4A-4dhgA:undetectable | 1dy4A-4dhgA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ejs | ELONGATOR COMPLEXPROTEIN 5ELONGATOR COMPLEXPROTEIN 6 (Saccharomycescerevisiae) |
PF10483(Elong_Iki1)no annotation | 5 | ALA C 243TYR B 57ASP B 107SER B 108THR B 76 | None | 1.23A | 1dy4A-4ejsC:undetectable | 1dy4A-4ejsC:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4c | MULTIDRUG RESISTANCEPROTEIN PGP-1 (Caenorhabditiselegans) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 5 | ALA A 308SER A 822GLU A 267THR A 868ARG A 873 | None | 1.31A | 1dy4A-4f4cA:undetectable | 1dy4A-4f4cA:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gis | ENOLASE (Vibrio harveyi) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | TYR A 124GLU A 231ASP A 232GLU A 257ASP A 311 | None MG A 405 (-2.7A) MG A 405 ( 4.8A) MG A 405 ( 2.4A)GOL A 404 (-2.8A) | 1.46A | 1dy4A-4gisA:undetectable | 1dy4A-4gisA:19.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4haq | GH7 FAMILY PROTEIN (Limnoriaquadripunctata) |
PF00840(Glyco_hydro_7) | 10 | ALA A 164TYR A 166TYR A 192ASP A 194GLN A 196GLU A 233ASP A 235GLU A 238ARG A 271ASP A 394 | NoneNoneNoneNoneCBI A 501 (-3.8A)NoneNoneCBI A 501 ( 4.3A)CBI A 501 (-3.2A)None | 0.28A | 1dy4A-4haqA:61.2 | 1dy4A-4haqA:53.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4it1 | PUTATIVE GLUCARATEDEHYDRATASE (Pseudomonasfluorescens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 267TYR A 244SER A 145GLU A 246ASP A 293 | NoneNoneNone MG A 501 (-2.8A)None | 1.15A | 1dy4A-4it1A:undetectable | 1dy4A-4it1A:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kws | D-MANNONATEDEHYDRATASE (Chromohalobactersalexigens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | TYR A 122GLU A 239ASP A 240GLU A 265ASP A 319 | None MG A 501 (-2.8A) MG A 501 ( 4.7A) MG A 501 ( 2.5A)GOL A 502 (-2.8A) | 1.48A | 1dy4A-4kwsA:undetectable | 1dy4A-4kwsA:19.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4v20 | CELLOBIOHYDROLASE (Aspergillusfumigatus) |
PF00840(Glyco_hydro_7) | 12 | ALA A 143TYR A 145TYR A 171ASP A 173SER A 174GLN A 175GLU A 212ASP A 214GLU A 217THR A 246ARG A 251ASP A 376 | NoneNoneNoneNoneNoneU63 A1443 (-4.4A)NoneNoneU63 A1443 ( 4.3A)U63 A1443 (-4.0A)U63 A1443 (-3.0A)U63 A1443 ( 4.9A) | 0.34A | 1dy4A-4v20A:65.2 | 1dy4A-4v20A:64.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4woj | ASPARTATESEMIALDEHYDEDEHYDROGENASE (Francisellatularensis) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | ALA A 352ASP A 26SER A 24GLU A 353ASP A 112 | None | 1.39A | 1dy4A-4wojA:undetectable | 1dy4A-4wojA:20.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xeb | GLUCANASE (Talaromycesfuniculosus) |
PF00840(Glyco_hydro_7) | 12 | ALA A 140TYR A 142TYR A 168ASP A 170SER A 171GLN A 172GLU A 209ASP A 211GLU A 214THR A 243ARG A 248ASP A 373 | CE6 A 505 ( 4.7A)CE6 A 505 (-4.3A)None K A 506 (-3.2A) K A 506 ( 4.8A)CBI A 504 (-4.4A) K A 506 (-2.6A) K A 506 ( 4.7A)CBI A 504 ( 4.4A)CBI A 504 (-3.1A)CBI A 504 (-2.8A)None | 0.30A | 1dy4A-4xebA:64.9 | 1dy4A-4xebA:64.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4zzp | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Dictyosteliumpurpureum) |
PF00840(Glyco_hydro_7) | 10 | ALA A 142TYR A 144TYR A 170ASP A 172GLN A 174GLU A 211ASP A 213GLU A 216ARG A 250ASP A 375 | None | 0.47A | 1dy4A-4zzpA:63.9 | 1dy4A-4zzpA:58.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4zzp | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Dictyosteliumpurpureum) |
PF00840(Glyco_hydro_7) | 6 | ALA A 142TYR A 144TYR A 170ASP A 172GLU A 211THR A 246 | None | 0.97A | 1dy4A-4zzpA:63.9 | 1dy4A-4zzpA:58.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4zzq | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Dictyosteliumdiscoideum) |
PF00840(Glyco_hydro_7) | 10 | ALA A 142TYR A 144TYR A 170ASP A 172GLN A 174GLU A 211ASP A 213GLU A 216ARG A 250ASP A 375 | None | 0.42A | 1dy4A-4zzqA:63.6 | 1dy4A-4zzqA:59.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aeb | LRA-12 (unculturedbacterium BLR12) |
PF00753(Lactamase_B) | 5 | ALA A 155TYR A 154TYR A 243SER A 200GLN A 116 | NoneNoneNoneNone ZN A1308 ( 2.5A) | 1.46A | 1dy4A-5aebA:undetectable | 1dy4A-5aebA:22.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5amp | CELLOBIOHYDROLASE I (Galactomycescandidus) |
PF00840(Glyco_hydro_7) | 11 | ALA A 143TYR A 145TYR A 171ASP A 173GLN A 175GLU A 212ASP A 214GLU A 217THR A 246ARG A 251ASP A 373 | None | 0.32A | 1dy4A-5ampA:64.2 | 1dy4A-5ampA:63.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5amp | CELLOBIOHYDROLASE I (Galactomycescandidus) |
PF00840(Glyco_hydro_7) | 10 | ALA A 143TYR A 145TYR A 171ASP A 173SER A 174GLN A 175GLU A 212ASP A 214THR A 246ARG A 251 | None | 0.60A | 1dy4A-5ampA:64.2 | 1dy4A-5ampA:63.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mch | CELLOBIOHYDROLASECHBI (Daphnia pulex) |
PF00840(Glyco_hydro_7) | 10 | ALA A 167TYR A 169TYR A 195ASP A 197GLN A 199GLU A 236ASP A 238GLU A 241ARG A 275ASP A 403 | NoneNoneNoneNoneGOL A 501 ( 4.6A)GOL A 501 (-3.3A)GOL A 501 (-2.9A)GOL A 501 (-3.5A)NoneNone | 0.49A | 1dy4A-5mchA:60.7 | 1dy4A-5mchA:51.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mch | CELLOBIOHYDROLASECHBI (Daphnia pulex) |
PF00840(Glyco_hydro_7) | 5 | TYR A 195ASP A 197GLN A 199GLU A 236ASP A 405 | NoneNoneGOL A 501 ( 4.6A)GOL A 501 (-3.3A)None | 1.19A | 1dy4A-5mchA:60.7 | 1dy4A-5mchA:51.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o5d | GLUCANASE (Trichodermaatroviride) |
no annotation | 12 | ALA A 143TYR A 145TYR A 171ASP A 173SER A 174GLN A 175GLU A 212ASP A 214GLU A 217THR A 246ARG A 251ASP A 369 | BTB A 604 (-3.5A)BTB A 604 (-3.8A)NoneBTB A 604 (-3.7A)BTB A 604 (-3.4A)BTB A 604 (-3.8A)BTB A 604 (-2.7A)BTB A 604 ( 3.4A)BTB A 604 ( 3.0A)NoneNoneNone | 0.52A | 1dy4A-5o5dA:68.9 | 1dy4A-5o5dA:13.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t3b | GLYCOSIDE HYDROLASE (Bacteroidesplebeius) |
no annotation | 5 | ALA A 383TYR A 341GLU A 367ARG A 108ASP A 421 | EDO A 505 (-3.4A)EDO A 505 ( 3.7A)EDO A 505 ( 4.9A)NoneNone | 1.38A | 1dy4A-5t3bA:undetectable | 1dy4A-5t3bA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0a | GLUCANASE (Trichodermaharzianum) |
no annotation | 8 | ALA A 144TYR A 146TYR A 170ASP A 172GLN A 174GLU A 196ASP A 198GLU A 201 | ALA A 144 ( 0.0A)TYR A 146 ( 1.3A)TYR A 170 ( 1.3A)ASP A 172 ( 0.5A)GLN A 174 ( 0.5A)GLU A 196 ( 0.6A)ASP A 198 (-0.6A)GLU A 201 (-0.5A) | 0.36A | 1dy4A-5w0aA:48.5 | 1dy4A-5w0aA:11.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0a | GLUCANASE (Trichodermaharzianum) |
no annotation | 6 | ALA A 144TYR A 146TYR A 170ASP A 198GLU A 201ASP A 322 | ALA A 144 ( 0.0A)TYR A 146 ( 1.3A)TYR A 170 ( 1.3A)ASP A 198 (-0.6A)GLU A 201 (-0.5A)ASP A 322 ( 0.6A) | 0.76A | 1dy4A-5w0aA:48.5 | 1dy4A-5w0aA:11.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w11 | GLUCANASE (Thermothelomycesthermophila) |
no annotation | 9 | ALA A 144SER A 175GLN A 176GLU A 213ASP A 215GLU A 218THR A 247ARG A 252ASP A 374 | NoneNoneCTR A 506 (-4.1A)CTR A 506 ( 4.5A)NoneCTR A 506 ( 4.3A)CTR A 506 (-2.7A)CTR A 506 (-3.0A)CTR A 506 ( 3.0A) | 0.64A | 1dy4A-5w11A:65.6 | 1dy4A-5w11A:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w11 | GLUCANASE (Thermothelomycesthermophila) |
no annotation | 11 | ALA A 144TYR A 146TYR A 172ASP A 174SER A 175GLN A 176GLU A 213ASP A 215GLU A 218ARG A 252ASP A 374 | NoneNoneNoneCTR A 506 ( 4.6A)NoneCTR A 506 (-4.1A)CTR A 506 ( 4.5A)NoneCTR A 506 ( 4.3A)CTR A 506 (-3.0A)CTR A 506 ( 3.0A) | 0.29A | 1dy4A-5w11A:65.6 | 1dy4A-5w11A:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yz0 | SERINE/THREONINE-PROTEIN KINASE ATR (Homo sapiens) |
no annotation | 5 | ALA A2101TYR A2102ASP A2118GLN A2114GLU A2105 | None | 1.15A | 1dy4A-5yz0A:undetectable | 1dy4A-5yz0A:9.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q2e | EXOCELLOBIOHYDROLASEI (Trichodermareesei) |
PF00840(Glyco_hydro_7) | 5 | HIS A 228TRP A 367TYR A 371ALA A 372TRP A 376 | GLC A 904 (-4.0A)NoneNoneNoneGLC A 904 (-3.5A) | 0.32A | 1dy4A-1q2eA:70.9 | 1dy4A-1q2eA:97.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9h | CELLOBIOHYDROLASE ICATALYTIC DOMAIN (Rasamsoniaemersonii) |
PF00840(Glyco_hydro_7) | 4 | HIS A 225TRP A 371ALA A 376TRP A 380 | None | 0.29A | 1dy4A-1q9hA:64.4 | 1dy4A-1q9hA:66.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1z3v | CELLULASE (Phanerochaetechrysosporium) |
PF00840(Glyco_hydro_7) | 4 | HIS A 223TRP A 364ALA A 369TRP A 373 | LAT A 500 ( 4.9A)NoneLAT A 500 ( 4.3A)LAT A 500 (-3.7A) | 0.29A | 1dy4A-1z3vA:62.2 | 1dy4A-1z3vA:55.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2buc | DIPEPTIDYL PEPTIDASEIV (Sus scrofa) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 4 | HIS A 748TRP A 627ALA A 654TRP A 629 | None | 1.34A | 1dy4A-2bucA:undetectable | 1dy4A-2bucA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g5t | DIPEPTIDYL PEPTIDASE4 (Homo sapiens) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 4 | HIS A 748TRP A 627ALA A 654TRP A 629 | None | 1.44A | 1dy4A-2g5tA:undetectable | 1dy4A-2g5tA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oae | DIPEPTIDYL PEPTIDASE4 (Rattusnorvegicus) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 4 | HIS A 749TRP A 628ALA A 655TRP A 630 | None | 1.44A | 1dy4A-2oaeA:undetectable | 1dy4A-2oaeA:21.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rfz | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Melanocarpusalbomyces) |
PF00840(Glyco_hydro_7) | 4 | HIS A 228TRP A 366ALA A 371TRP A 375 | CTR A 431 (-4.1A)CTR A 432 (-4.6A)NoneCTR A 431 (-4.0A) | 0.44A | 1dy4A-2rfzA:61.9 | 1dy4A-2rfzA:50.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2yg1 | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Heterobasidionannosum) |
PF00840(Glyco_hydro_7) | 4 | HIS A 230TRP A 375ALA A 380TRP A 384 | None | 0.35A | 1dy4A-2yg1A:61.7 | 1dy4A-2yg1A:56.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bmw | CYCLOMALTODEXTRINGLUCANOTRANSFERASE (Thermoanaerobacteriumthermosulfurigenes) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 4 | HIS A 141TRP A 239TYR A 211ALA A 215 | ACI A 694 (-3.9A)NoneNoneNone | 1.44A | 1dy4A-3bmwA:undetectable | 1dy4A-3bmwA:22.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4haq | GH7 FAMILY PROTEIN (Limnoriaquadripunctata) |
PF00840(Glyco_hydro_7) | 5 | HIS A 249TRP A 392TYR A 396ALA A 397TRP A 401 | NoneNoneCBI A 501 (-4.5A)CBI A 501 ( 4.4A)CBI A 501 ( 3.8A) | 0.29A | 1dy4A-4haqA:61.2 | 1dy4A-4haqA:53.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcl | CYCLOMALTODEXTRINGLUCANOTRANSFERASE (Paenibacillusmacerans) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 4 | HIS A 140TRP A 238TYR A 210ALA A 214 | GOL A 711 (-4.0A)NoneNoneNone | 1.45A | 1dy4A-4jclA:undetectable | 1dy4A-4jclA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jjj | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Thermobifidafusca) |
PF02011(Glyco_hydro_48) | 4 | HIS A 32TRP A 414ALA A 504TRP A 420 | CBI A 701 ( 4.4A)CBI A 701 ( 3.9A)NoneNone | 1.31A | 1dy4A-4jjjA:undetectable | 1dy4A-4jjjA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lyp | EXO-BETA-1,4-MANNOSIDASE (Rhizomucormiehei) |
no annotation | 4 | HIS A 379TRP A 257ALA A 305TRP A 384 | TRS A 503 (-4.3A)TRS A 503 (-3.7A)NoneNone | 1.44A | 1dy4A-4lypA:undetectable | 1dy4A-4lypA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pcs | ALPHA-L-FUCOSIDASE (Bacteroidesthetaiotaomicron) |
PF01120(Alpha_L_fucos) | 4 | TRP A 100TYR A 82ALA A 93TRP A 77 | None | 1.37A | 1dy4A-4pcsA:undetectable | 1dy4A-4pcsA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7k | HYPOTHETICAL PROTEINJHP0584 (Helicobacterpylori) |
no annotation | 4 | HIS A 155TRP A 46ALA A 83TRP A 99 | None | 0.94A | 1dy4A-4r7kA:undetectable | 1dy4A-4r7kA:17.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4v20 | CELLOBIOHYDROLASE (Aspergillusfumigatus) |
PF00840(Glyco_hydro_7) | 4 | HIS A 228TRP A 374ALA A 379TRP A 383 | U63 A1443 (-4.2A)NoneU63 A1443 ( 4.9A)U63 A1443 (-3.6A) | 0.35A | 1dy4A-4v20A:65.2 | 1dy4A-4v20A:64.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4zzp | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Dictyosteliumpurpureum) |
PF00840(Glyco_hydro_7) | 4 | HIS A 227TRP A 373ALA A 378TRP A 382 | None | 0.58A | 1dy4A-4zzpA:63.9 | 1dy4A-4zzpA:58.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4zzq | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Dictyosteliumdiscoideum) |
PF00840(Glyco_hydro_7) | 4 | HIS A 227TRP A 373ALA A 378TRP A 382 | None | 0.48A | 1dy4A-4zzqA:63.6 | 1dy4A-4zzqA:59.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5amp | CELLOBIOHYDROLASE I (Galactomycescandidus) |
PF00840(Glyco_hydro_7) | 5 | HIS A 228TRP A 371TYR A 375ALA A 376TRP A 380 | None | 0.35A | 1dy4A-5ampA:64.2 | 1dy4A-5ampA:63.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ax7 | PYRUVYL TRANSFERASE1 (Schizosaccharomycespombe) |
PF04230(PS_pyruv_trans) | 4 | HIS A 351TRP A 297TYR A 320ALA A 108 | None | 1.11A | 1dy4A-5ax7A:undetectable | 1dy4A-5ax7A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nx7 | PENTALENENE SYNTHASE (Streptomycesclavuligerus) |
no annotation | 4 | HIS A 152TRP A 145ALA A 121TRP A 76 | None | 1.23A | 1dy4A-5nx7A:undetectable | 1dy4A-5nx7A:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nz7 | CELLODEXTRINPHOSPHORYLASE (Ruminiclostridiumthermocellum) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 4 | HIS A 677TRP A 894ALA A 754TRP A 755 | None | 1.27A | 1dy4A-5nz7A:undetectable | 1dy4A-5nz7A:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o5d | GLUCANASE (Trichodermaatroviride) |
no annotation | 4 | HIS A 228TRP A 367ALA A 372TRP A 376 | GOL A 608 (-4.0A)GOL A 607 ( 3.5A)NoneBTB A 604 (-4.9A) | 0.35A | 1dy4A-5o5dA:68.9 | 1dy4A-5o5dA:13.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6et8 | - (-) |
no annotation | 4 | HIS A 78TRP A 27ALA A 53TRP A 56 | BWH A 301 (-4.1A)BWH A 301 (-3.6A)NoneNone | 1.33A | 1dy4A-6et8A:undetectable | 1dy4A-6et8A:undetectable |