SIMILAR PATTERNS OF AMINO ACIDS FOR 1DWC_H_MITH1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 SO4  A 248 (-3.9A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 (-3.3A)
 0.46A 1dwcH-1a0jA:
33.7		 1dwcH-1a0jA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 0GJ  A 245 (-2.7A)
0GJ  A 245 (-3.1A)
0GJ  A 245 (-1.4A)
None
0GJ  A 245 ( 4.2A)
 0.48A 1dwcH-1a5iA:
33.2		 1dwcH-1a5iA:
32.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 0GJ  A   1 ( 2.7A)
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 ( 4.3A)
 0.35A 1dwcH-1bqyA:
32.2		 1dwcH-1bqyA:
33.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 HIS A 460
ASP A 611
SER A 617
TRP A 640
GLY A 648
 SO4  A2001 ( 3.9A)
None
SO4  A2001 ( 2.7A)
None
None
 0.45A 1dwcH-1elvA:
30.9		 1dwcH-1elvA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 HIS A  57
ASP C 189
SER C 195
TRP C 215
GLY C 226
 None
 0.34A 1dwcH-1eptA:
2.2		 1dwcH-1eptA:
15.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.3A)
 0.47A 1dwcH-1fiwA:
34.8		 1dwcH-1fiwA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 ( 3.7A)
 0.41A 1dwcH-1fizA:
34.3		 1dwcH-1fizA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.3A)
 0.56A 1dwcH-1fxyA:
32.6		 1dwcH-1fxyA:
37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
BEN  A 250 (-2.9A)
BEN  A 250 (-3.6A)
None
BEN  A 250 (-3.3A)
 0.33A 1dwcH-1h4wA:
34.1		 1dwcH-1h4wA:
37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 HIS E  57
ASP E 189
SER E 195
TRP E 215
GLY E 226
 None
 0.51A 1dwcH-1h9hE:
33.7		 1dwcH-1h9hE:
38.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		5 HIS A  81
TRP A 296
ILE A  65
ASP A  54
GLY A  55
 None
TRS  A 704 (-3.8A)
None
None
None
 1.46A 1dwcH-1hjuA:
undetectable		 1dwcH-1hjuA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		6 HIS H  57
ILE H 174
ASP H 189
GLU H 192
TRP H 215
GLY H 226
 None
 0.64A 1dwcH-1id5H:
43.0		 1dwcH-1id5H:
87.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		6 HIS H  57
ILE H 174
ASP H 189
SER H 195
TRP H 215
GLY H 226
 None
 0.59A 1dwcH-1id5H:
43.0		 1dwcH-1id5H:
87.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 HIS T  57
ASP T 189
SER T 195
TRP T 215
GLY T 226
 SO4  T 600 (-3.8A)
ZEN  T   1 ( 3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
 0.37A 1dwcH-1j17T:
34.3		 1dwcH-1j17T:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		5 HIS H  57
ASP H 189
SER H 195
TRP H 215
GLY H 226
 None
 0.42A 1dwcH-1kigH:
34.5		 1dwcH-1kigH:
39.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mbq TRYPSIN

(Oncorhynchus
keta) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.4A)
 0.34A 1dwcH-1mbqA:
33.7		 1dwcH-1mbqA:
37.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		7 HIS K  57
TYR K  60
TRP K  60
ILE K 174
SER K 195
TRP K 215
GLY K 226
 None
 0.58A 1dwcH-1mkxK:
36.6		 1dwcH-1mkxK:
87.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1npm NEUROPSIN

(Mus musculus) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.51A 1dwcH-1npmA:
33.3		 1dwcH-1npmA:
33.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS H  57
ASP H 189
SER H 195
TRP H 215
GLY H 226
 CR9  H 256 (-3.9A)
CR9  H 256 (-2.4A)
CR9  H 256 (-1.5A)
None
CR9  H 256 (-3.0A)
 0.45A 1dwcH-1o5fH:
34.7		 1dwcH-1o5fH:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pfx FACTOR IXA

(Sus scrofa) 		PF00089
(Trypsin) 		5 HIS C  57
ASP C 189
SER C 195
TRP C 215
GLY C 226
 0G6  C 301 (-2.5A)
0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 ( 3.5A)
 0.61A 1dwcH-1pfxC:
34.0		 1dwcH-1pfxC:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pq5 TRYPSIN

(Fusarium
oxysporum) 		PF00089
(Trypsin) 		5 HIS A  56
ASP A 189
SER A 195
TRP A 212
GLY A 223
 ARG  A 703 (-4.3A)
ARG  A 703 (-2.0A)
ARG  A 703 (-2.3A)
None
ARG  A 703 (-2.6A)
 0.40A 1dwcH-1pq5A:
32.4		 1dwcH-1pq5A:
34.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 HIS A 483
ASP A 627
SER A 633
TRP A 655
GLY A 667
 None
NA  A 800 ( 4.6A)
GOL  A 701 (-3.0A)
None
GOL  A 701 ( 4.0A)
 0.39A 1dwcH-1q3xA:
34.6		 1dwcH-1q3xA:
28.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		5 HIS G  57
ASP G 189
SER G 195
TRP G 215
GLY G 226
 None
 0.49A 1dwcH-1sgfG:
32.6		 1dwcH-1sgfG:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.36A 1dwcH-1ym0A:
35.4		 1dwcH-1ym0A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 368  A 901 (-4.0A)
368  A 901 (-2.8A)
368  A 901 (-1.4A)
None
368  A 901 (-3.5A)
 0.28A 1dwcH-1zlrA:
34.9		 1dwcH-1zlrA:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eek TRYPSIN-1

(Gadus morhua) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
BEN  A 301 (-2.7A)
BEN  A 301 (-3.4A)
None
BEN  A 301 (-3.2A)
 0.37A 1dwcH-2eekA:
33.1		 1dwcH-2eekA:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
 0.46A 1dwcH-2ei8A:
35.4		 1dwcH-2ei8A:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 227
 None
 0.40A 1dwcH-2f91A:
34.3		 1dwcH-2f91A:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
BEN  A 245 (-3.4A)
 0.40A 1dwcH-2oq5A:
34.7		 1dwcH-2oq5A:
37.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 TYR A 576
TRP A 598
ILE A 559
GLU A 578
GLY A 588
 None
 1.17A 1dwcH-2p2mA:
undetectable		 1dwcH-2p2mA:
16.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pks THROMBIN HEAVY CHAIN
FRAGMENT

(Homo sapiens) 		PF00089
(Trypsin) 		5 ILE C 209
ASP C 229
SER C 235
TRP C 257
GLY C 268
 G44  C 101 (-3.9A)
G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
G44  C 101 (-4.1A)
G44  C 101 (-3.0A)
 0.40A 1dwcH-2pksC:
11.9		 1dwcH-2pksC:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.55A 1dwcH-2psyA:
33.9		 1dwcH-2psyA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS B 485
ASP B 631
SER B 637
TRP B 659
GLY B 668
 None
 0.27A 1dwcH-2qy0B:
32.9		 1dwcH-2qy0B:
38.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.30A 1dwcH-2r0lA:
35.0		 1dwcH-2r0lA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS S  57
ASP S 189
SER S 195
TRP S 215
GLY S 226
 None
 0.57A 1dwcH-2wpmS:
35.2		 1dwcH-2wpmS:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  59
ASP A 203
SER A 209
TRP A 229
GLY A 240
 None
11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.6A)
 0.43A 1dwcH-2zecA:
33.2		 1dwcH-2zecA:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.5A)
 0.30A 1dwcH-3beuA:
31.4		 1dwcH-3beuA:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS H  57
ASP H 189
SER H 195
TRP H 215
GLY H 226
 0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
0G6  H   1 (-4.1A)
0G6  H   1 ( 3.9A)
 0.54A 1dwcH-3f6uH:
36.1		 1dwcH-3f6uH:
40.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS B 490
ASP B 640
SER B 646
TRP B 668
GLY B 679
 None
 0.39A 1dwcH-3govB:
36.3		 1dwcH-3govB:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gym PROSTASIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.53A 1dwcH-3gymA:
33.7		 1dwcH-3gymA:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nxp PRETHROMBIN-1

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		5 HIS A 457
TYR A 460
ILE A 574
SER A 595
GLY A 626
 None
 0.85A 1dwcH-3nxpA:
29.3		 1dwcH-3nxpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS B  57
TYR B  60
ILE B 174
ASP B 189
GLU B 192
SER B 195
 None
 0.83A 1dwcH-3r3gB:
43.6		 1dwcH-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		7 HIS B  57
TYR B  60
ILE B 174
ASP B 189
SER B 195
TRP B 215
GLY B 226
 None
 0.39A 1dwcH-3r3gB:
43.6		 1dwcH-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 TYR B  60
TRP B  60
ILE B 174
ASP B 189
TRP B 215
 None
 0.83A 1dwcH-3r3gB:
43.6		 1dwcH-3r3gB:
97.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE

(Xenopus laevis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 HIS A 409
ILE A 344
GLU A 365
SER A 368
GLY A 292
 None
 1.45A 1dwcH-3w0lA:
undetectable		 1dwcH-3w0lA:
18.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS E 478
ASP E 639
SER E 645
TRP E 667
GLY E 680
 None
 0.70A 1dwcH-4iw4E:
33.0		 1dwcH-4iw4E:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m7g TRYPSIN-LIKE
PROTEASE

(Saccharopolyspora
erythraea) 		PF00089
(Trypsin) 		5 HIS A  42
ASP A 173
SER A 179
TRP A 195
GLY A 206
 None
 0.42A 1dwcH-4m7gA:
32.2		 1dwcH-4m7gA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 3KM  A 900 ( 4.4A)
3KM  A 900 (-2.9A)
3KM  A 900 (-3.6A)
None
3KM  A 900 (-3.2A)
 0.42A 1dwcH-4r0iA:
36.4		 1dwcH-4r0iA:
35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Ochrobactrum
anthropi) 		PF01547
(SBP_bac_1) 		5 HIS A 146
TRP A 252
ASP A 355
TRP A 150
GLY A 358
 GLC  A 501 (-4.4A)
GLC  A 501 (-4.0A)
None
None
None
 1.49A 1dwcH-4r2bA:
undetectable		 1dwcH-4r2bA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT
PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 HIS S  13
ILE S  78
GLU L  34
SER S  21
GLY S 112
 None
None
None
None
SF4  S2001 ( 3.7A)
 1.50A 1dwcH-4u9iS:
undetectable		 1dwcH-4u9iS:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.48A 1dwcH-4wwyA:
33.7		 1dwcH-4wwyA:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ylq COAGULATION FACTOR
VII

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS H  57
ASP H 189
SER H 195
TRP H 215
GLY H 226
 0Z7  H 501 (-2.6A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.0A)
 0.49A 1dwcH-4ylqH:
34.6		 1dwcH-4ylqH:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE

(Podospora
anserina) 		PF01596
(Methyltransf_3) 		5 HIS A  34
TYR A 114
ILE A  58
ASP A 144
SER A  76
 None
None
None
SAM  A1001 (-3.6A)
None
 1.33A 1dwcH-4ymgA:
undetectable		 1dwcH-4ymgA:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.45A 1dwcH-5f8zA:
34.7		 1dwcH-5f8zA:
39.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms3 KALLIKREIN-8

(Homo sapiens) 		no annotation 5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.45A 1dwcH-5ms3A:
33.2		 1dwcH-5ms3A:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		6 HIS B  58
TYR B  62
ILE B 194
ASP B 214
SER B 220
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 (-3.7A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.6A)
 0.40A 1dwcH-5to3B:
44.9		 1dwcH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		5 TYR B  62
ILE B 194
ASP B 214
GLU B 217
GLY B 253
 0G6  B 501 (-3.7A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.8A)
0G6  B 501 (-3.6A)
 1.01A 1dwcH-5to3B:
44.9		 1dwcH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		5 TYR B  62
TRP B  65
ILE B 194
ASP B 214
GLY B 253
 0G6  B 501 (-3.7A)
0G6  B 501 (-4.8A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.6A)
 0.80A 1dwcH-5to3B:
44.9		 1dwcH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 5 HIS A 475
ASP A 626
SER A 632
TRP A 655
GLY A 663
 None
 0.55A 1dwcH-5ubmA:
31.5		 1dwcH-5ubmA:
35.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII

(Homo sapiens) 		no annotation 5 HIS B  57
ASP B 189
SER B 195
TRP B 215
GLY B 226
 SO4  B 304 (-3.8A)
BEN  B 301 (-2.7A)
SO4  B 304 ( 2.5A)
None
BEN  B 301 (-3.1A)
 0.49A 1dwcH-6b74B:
34.5		 1dwcH-6b74B:
16.47