SIMILAR PATTERNS OF AMINO ACIDS FOR 1DVX_B_DIFB125

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1apy ASPARTYLGLUCOSAMINID
ASE

(Homo sapiens) 		PF01112
(Asparaginase_2) 		4 LEU A  82
ALA A  66
LEU A  64
SER A  55
 None
 1.06A 1dvxA-1apyA:
undetectable		 1dvxA-1apyA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e12 HALORHODOPSIN

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 LEU A  33
LEU A  81
SER A  82
THR A  85
 None
 1.00A 1dvxA-1e12A:
undetectable		 1dvxA-1e12A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f80 HOLO-(ACYL CARRIER
PROTEIN) SYNTHASE

(Bacillus
subtilis) 		PF01648
(ACPS) 		4 LEU A   7
ALA A 111
SER A 102
THR A 104
 None
None
None
NA  A1255 (-3.8A)
 0.49A 1dvxA-1f80A:
undetectable		 1dvxA-1f80A:
24.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 LEU A  17
ALA A 108
LEU A 110
SER A 115
SER A 117
 None
 0.82A 1dvxA-1gkeA:
22.2		 1dvxA-1gkeA:
84.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 LEU A  17
ALA A 108
LEU A 110
SER A 115
THR A 119
 None
 0.53A 1dvxA-1gkeA:
22.2		 1dvxA-1gkeA:
84.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gns SUBTILISIN BPN'

(Bacillus
amyloliquefaciens) 		PF00082
(Peptidase_S8) 		4 ALA A 137
LEU A 135
SER A 130
SER A 132
 None
 0.86A 1dvxA-1gnsA:
undetectable		 1dvxA-1gnsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 LYS A 361
LEU A 357
ALA A 360
THR A 352
 None
 0.74A 1dvxA-1jmyA:
0.0		 1dvxA-1jmyA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 4 LYS T 223
LEU T 157
SER T 154
THR T 150
 None
 0.99A 1dvxA-1lthT:
undetectable		 1dvxA-1lthT:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans) 		PF01263
(Aldose_epim) 		4 LEU A1018
ALA A1023
LEU A1025
THR A1060
 None
 1.05A 1dvxA-1lurA:
0.0		 1dvxA-1lurA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qas PHOSPHOLIPASE C
DELTA-1

(Rattus
norvegicus) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 LEU A 387
LEU A 340
SER A 308
SER A 310
 None
 1.00A 1dvxA-1qasA:
2.9		 1dvxA-1qasA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 1.01A 1dvxA-1sb3B:
undetectable		 1dvxA-1sb3B:
16.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		5 LEU A  17
ALA A 108
LEU A 110
SER A 115
THR A 119
 None
 0.38A 1dvxA-1sn2A:
21.0		 1dvxA-1sn2A:
55.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		6 LEU A  17
ALA A 108
LEU A 110
SER A 115
SER A 117
THR A 119
 None
 0.44A 1dvxA-1tfpA:
19.9		 1dvxA-1tfpA:
74.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE

(Staphylococcus
aureus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LYS A   2
ALA A 170
SER A 315
THR A 317
 None
 0.96A 1dvxA-1tvzA:
undetectable		 1dvxA-1tvzA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uun MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		4 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.61A 1dvxA-1uunA:
undetectable		 1dvxA-1uunA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2

(Infectious
bursal disease
virus) 		PF01766
(Birna_VP2) 		4 ALA J 366
SER J 103
SER J 105
THR J 107
 None
 0.82A 1dvxA-1wcdJ:
undetectable		 1dvxA-1wcdJ:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LEU A 289
ALA A 292
SER A 270
SER A 266
 None
 0.99A 1dvxA-1x9eA:
undetectable		 1dvxA-1x9eA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykd ADENYLATE CYCLASE

(Anabaena sp.) 		PF01590
(GAF) 		4 LYS A 200
ALA A 101
LEU A 180
THR A 104
 None
 0.87A 1dvxA-1ykdA:
undetectable		 1dvxA-1ykdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 1.06A 1dvxA-1yr2A:
undetectable		 1dvxA-1yr2A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		4 LEU A 108
LEU A  49
SER A  34
SER A  36
 None
 0.64A 1dvxA-1zliA:
undetectable		 1dvxA-1zliA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		4 LEU A   2
ALA A 216
LEU A 228
SER A 227
 None
 1.00A 1dvxA-1zzgA:
undetectable		 1dvxA-1zzgA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4a MALATE DEHYDROGENASE

(Aeropyrum
pernix) 		no annotation 4 LEU B  41
ALA B  44
SER B  59
SER B  57
 None
 1.03A 1dvxA-2d4aB:
undetectable		 1dvxA-2d4aB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvl ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A  46
ALA A  42
LEU A  48
SER A  89
 None
 0.96A 1dvxA-2dvlA:
undetectable		 1dvxA-2dvlA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbe PREDICTED: SIMILAR
TO RET FINGER
PROTEIN-LIKE 1

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 ALA A 113
LEU A 101
SER A  96
THR A 115
 None
 1.01A 1dvxA-2fbeA:
undetectable		 1dvxA-2fbeA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ALA A 252
LEU A 254
SER A 263
THR A 267
 HEX  A 807 ( 3.9A)
None
None
HEX  A 807 (-3.4A)
 0.52A 1dvxA-2gskA:
undetectable		 1dvxA-2gskA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hd7 TWINFILIN-1

(Mus musculus) 		PF00241
(Cofilin_ADF) 		4 LEU A 198
LEU A 193
SER A 252
SER A 194
 None
 1.08A 1dvxA-2hd7A:
undetectable		 1dvxA-2hd7A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 LEU A   6
LEU A  76
SER A  81
SER A  83
 None
 0.87A 1dvxA-2o5vA:
undetectable		 1dvxA-2o5vA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9u MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		4 LEU A  62
ALA A 164
LEU A 166
THR A 176
 LEU  A  62 ( 0.5A)
ALA  A 164 ( 0.0A)
LEU  A 166 ( 0.5A)
THR  A 176 ( 0.8A)
 0.54A 1dvxA-2v9uA:
3.3		 1dvxA-2v9uA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w45 ALKALINE EXONUCLEASE

(Human
gammaherpesvirus
4) 		PF01771
(Herpes_alk_exo) 		4 LEU A 216
SER A 108
SER A 104
THR A 100
 None
 0.96A 1dvxA-2w45A:
undetectable		 1dvxA-2w45A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 ALA A 137
SER A 183
SER A 185
THR A 187
 5AD  A1746 ( 3.9A)
None
EDO  A1754 (-3.2A)
None
 0.69A 1dvxA-2xijA:
undetectable		 1dvxA-2xijA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 ALA A  53
LEU A  78
SER A  98
THR A  51
 None
 0.94A 1dvxA-2z7xA:
undetectable		 1dvxA-2z7xA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7x FK506-BINDING
PROTEIN 6

(Homo sapiens) 		PF00254
(FKBP_C) 		4 LYS A 113
LEU A 111
LEU A 134
SER A  62
 None
 0.99A 1dvxA-3b7xA:
undetectable		 1dvxA-3b7xA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		4 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.82A 1dvxA-3b8kA:
undetectable		 1dvxA-3b8kA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.80A 1dvxA-3bdwB:
undetectable		 1dvxA-3bdwB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 LEU A 172
SER A 196
SER A 175
THR A 154
 None
 1.06A 1dvxA-3bz5A:
undetectable		 1dvxA-3bz5A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX

(Escherichia
coli) 		PF03320
(FBPase_glpX) 		4 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.37A 1dvxA-3d1rA:
undetectable		 1dvxA-3d1rA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		4 ALA A 444
LEU A 442
SER A 440
SER A 401
 None
 0.86A 1dvxA-3e0gA:
undetectable		 1dvxA-3e0gA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A 320
LEU A 359
SER A 368
SER A 370
 None
 0.80A 1dvxA-3e0gA:
undetectable		 1dvxA-3e0gA:
14.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		4 LEU A  17
LEU A 110
SER A 115
SER A 117
 IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
None
IFA  A3000 (-3.9A)
 0.82A 1dvxA-3fc8A:
24.2		 1dvxA-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 115
THR A 119
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
IFA  A3000 ( 4.9A)
 0.80A 1dvxA-3fc8A:
24.2		 1dvxA-3fc8A:
99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsi PHOSPHATIDYLSERINE
SYNTHASE

(Haemophilus
influenzae) 		PF13091
(PLDc_2) 		4 LEU A 373
LEU A 393
SER A 242
SER A 244
 None
 0.68A 1dvxA-3hsiA:
undetectable		 1dvxA-3hsiA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		4 LEU A 112
ALA A 142
LEU A 115
SER A 116
 None
None
None
CEW  A 501 (-3.1A)
 1.07A 1dvxA-3humA:
undetectable		 1dvxA-3humA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 LEU A 500
SER A 327
SER A 329
THR A 331
 None
 0.87A 1dvxA-3hvdA:
undetectable		 1dvxA-3hvdA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		4 LEU A 173
LEU A 146
SER A 224
THR A 226
 None
 0.65A 1dvxA-3i44A:
undetectable		 1dvxA-3i44A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		4 LEU A 184
LEU A 157
SER A 235
THR A 237
 None
 0.69A 1dvxA-3iwkA:
undetectable		 1dvxA-3iwkA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwj HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00270
(DEAD) 		4 LEU A  78
ALA A 148
SER A 182
THR A 178
 None
 0.87A 1dvxA-3mwjA:
undetectable		 1dvxA-3mwjA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		4 ALA A 304
LEU A 334
SER A 296
THR A 301
 None
None
None
GOL  A 341 (-4.6A)
 1.00A 1dvxA-3ntxA:
undetectable		 1dvxA-3ntxA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p54 ENVELOPE
GLYCOPROTEIN

(Japanese
encephalitis
virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 LEU A 239
SER A  89
SER A 120
THR A 122
 None
 1.08A 1dvxA-3p54A:
undetectable		 1dvxA-3p54A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf0 IMELYSIN-LIKE
PROTEIN

(Psychrobacter
arcticus) 		PF09375
(Peptidase_M75) 		4 LEU A 275
ALA A 281
LEU A 277
SER A 278
 None
 1.07A 1dvxA-3pf0A:
undetectable		 1dvxA-3pf0A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU B 280
LEU B 264
SER B 317
THR B 319
 None
 0.68A 1dvxA-3prxB:
3.5		 1dvxA-3prxB:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		4 LEU A  68
LEU A  65
SER A  62
THR A  87
 None
 1.09A 1dvxA-3q1yA:
undetectable		 1dvxA-3q1yA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5x D-ALANINE--D-ALANINE
LIGASE

(Bacillus
anthracis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ALA A 270
LEU A 272
SER A 183
THR A 268
 None
 1.02A 1dvxA-3r5xA:
undetectable		 1dvxA-3r5xA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		4 LEU A 307
ALA A 207
LEU A 203
SER A 200
 None
None
SAM  A 801 ( 4.7A)
SAM  A 801 (-3.0A)
 0.93A 1dvxA-3v8vA:
undetectable		 1dvxA-3v8vA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvi TYPE-2 RESTRICTION
ENZYME HINDIII

(Haemophilus
influenzae) 		PF09518
(RE_HindIII) 		4 LEU A  78
ALA A  74
LEU A  80
SER A  82
 None
 1.07A 1dvxA-3wviA:
undetectable		 1dvxA-3wviA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 LEU A 743
ALA A 238
SER A 302
SER A 298
 None
 0.92A 1dvxA-4a01A:
undetectable		 1dvxA-4a01A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		4 ALA A 221
SER A 217
SER A 191
THR A 193
 None
 1.01A 1dvxA-4a9aA:
undetectable		 1dvxA-4a9aA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buh CLONE M0418 SCFV

(Homo sapiens) 		PF07686
(V-set) 		4 ALA A 216
SER A 164
SER A 162
THR A 160
 None
 0.95A 1dvxA-4buhA:
undetectable		 1dvxA-4buhA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		4 LYS A 295
LEU A 297
LEU A 290
SER A 320
 None
 0.99A 1dvxA-4conA:
undetectable		 1dvxA-4conA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glw DNA LIGASE

(Streptococcus
pneumoniae) 		PF01653
(DNA_ligase_aden) 		4 ALA A 126
SER A 114
SER A 116
THR A 118
 None
 0.38A 1dvxA-4glwA:
undetectable		 1dvxA-4glwA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 LEU M 287
LEU M 299
SER M 308
SER M 310
 None
 0.95A 1dvxA-4gq2M:
0.4		 1dvxA-4gq2M:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyl STAGE II SPORULATION
PROTEIN

(Haliangium
ochraceum) 		PF01740
(STAS) 		4 ALA A  55
LEU A  20
SER A  50
THR A  22
 None
 1.04A 1dvxA-4hylA:
undetectable		 1dvxA-4hylA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		4 LEU A 184
LEU A 157
SER A 235
THR A 237
 None
None
None
NAD  A 601 (-4.2A)
 0.68A 1dvxA-4i8qA:
undetectable		 1dvxA-4i8qA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A  78
ALA A 148
SER A 182
THR A 178
 None
 0.85A 1dvxA-4kbfA:
undetectable		 1dvxA-4kbfA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 342
LEU A 367
SER A 391
THR A 360
 None
 0.99A 1dvxA-4m7eA:
undetectable		 1dvxA-4m7eA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.85A 1dvxA-4mr0A:
undetectable		 1dvxA-4mr0A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 238
LEU A 240
SER A 241
THR A 244
 None
 0.97A 1dvxA-4mz0A:
undetectable		 1dvxA-4mz0A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ALA A 728
SER A 724
SER A 748
THR A 750
 None
 0.89A 1dvxA-4om9A:
undetectable		 1dvxA-4om9A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5i CHEMOKINE BINDING
PROTEIN

(Orf virus) 		PF02250
(Orthopox_35kD) 		4 LEU A 144
LEU A  85
SER A  91
SER A  70
 None
 0.98A 1dvxA-4p5iA:
undetectable		 1dvxA-4p5iA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD

(Escherichia
coli) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A 387
LEU A 361
SER A 353
SER A 351
 None
 1.00A 1dvxA-4pl0A:
undetectable		 1dvxA-4pl0A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A  94
LEU A 115
SER A 138
SER A 114
 None
 0.89A 1dvxA-4psjA:
undetectable		 1dvxA-4psjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 118
LEU A 139
SER A 162
SER A 138
 None
 0.99A 1dvxA-4psjA:
undetectable		 1dvxA-4psjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 142
LEU A 163
SER A 186
SER A 162
 None
 0.97A 1dvxA-4psjA:
undetectable		 1dvxA-4psjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 166
LEU A 187
SER A 210
SER A 186
 None
 1.03A 1dvxA-4psjA:
undetectable		 1dvxA-4psjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 190
LEU A 211
SER A 234
SER A 210
 None
 1.01A 1dvxA-4psjA:
undetectable		 1dvxA-4psjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvg SIBL

(Streptosporangium
sibiricum) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 LEU A 242
LEU A 273
SER A 341
SER A 339
 None
 0.91A 1dvxA-4qvgA:
undetectable		 1dvxA-4qvgA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uob ENDONUCLEASE III-3

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		4 LEU A 313
ALA A 255
SER A 321
SER A 319
 SF4  A1329 ( 4.8A)
SF4  A1329 ( 4.7A)
None
None
 0.98A 1dvxA-4uobA:
undetectable		 1dvxA-4uobA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnz LIGHT CHAIN OF
ANTIBODY VRC06B

(Homo sapiens) 		no annotation 4 ALA L  98
SER L  14
SER L  12
THR L  10
 None
NAG  L 301 ( 4.2A)
None
None
 0.85A 1dvxA-4xnzL:
3.7		 1dvxA-4xnzL:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)

(Candidatus
Korarchaeum
cryptofilum) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		4 LYS A 240
ALA A 241
SER A 183
SER A 160
 None
 1.08A 1dvxA-4xz3A:
undetectable		 1dvxA-4xz3A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 255
SER A 257
SER A 233
THR A 209
 None
 0.76A 1dvxA-4z64A:
undetectable		 1dvxA-4z64A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 LEU A 380
ALA A 378
SER A 389
THR A 376
 None
 0.95A 1dvxA-4zxiA:
undetectable		 1dvxA-4zxiA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Colwellia
psychrerythraea) 		PF01791
(DeoC) 		4 ALA A   8
SER A 236
SER A 240
THR A 244
 None
 1.02A 1dvxA-5c5yA:
undetectable		 1dvxA-5c5yA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjj PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Campylobacter
jejuni) 		PF00551
(Formyl_trans_N) 		4 ALA A   6
LEU A  39
SER A  10
THR A  88
 None
None
None
GOL  A 201 (-3.7A)
 0.71A 1dvxA-5cjjA:
undetectable		 1dvxA-5cjjA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		4 LEU A  46
LEU A  49
SER A  53
THR A 716
 None
 0.91A 1dvxA-5e3cA:
undetectable		 1dvxA-5e3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 LEU A 356
LEU A 359
SER A 361
THR A 365
 None
 0.92A 1dvxA-5fsaA:
undetectable		 1dvxA-5fsaA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 167
SER A 190
SER A 166
THR A 142
 None
 0.99A 1dvxA-5gr8A:
undetectable		 1dvxA-5gr8A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR

(Acinetobacter
sp. ADP1) 		PF01614
(IclR) 		4 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 1.03A 1dvxA-5hpiA:
undetectable		 1dvxA-5hpiA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m76 LIGHT CHAIN DIMER

(Homo sapiens) 		no annotation 4 LEU A 135
ALA A 133
LEU A 181
THR A 184
 None
 1.08A 1dvxA-5m76A:
undetectable		 1dvxA-5m76A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr4 GDNF FAMILY RECEPTOR
ALPHA-2

(Homo sapiens) 		no annotation 4 ALA C  81
SER C  51
SER C  55
THR C  59
 None
 1.07A 1dvxA-5mr4C:
undetectable		 1dvxA-5mr4C:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 ALA A 426
SER A 407
SER A 405
THR A 403
 None
 0.91A 1dvxA-5n8pA:
undetectable		 1dvxA-5n8pA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 ALA A 426
SER A 407
SER A 405
THR A 403
 None
 0.91A 1dvxA-5n97A:
undetectable		 1dvxA-5n97A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 4 LYS A 326
SER A 398
SER A 400
THR A 402
 None
 0.88A 1dvxA-5na7A:
undetectable		 1dvxA-5na7A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no4 30S RIBOSOMAL
PROTEIN S7

(Escherichia
coli) 		PF00177
(Ribosomal_S7) 		4 ALA G 121
SER G  41
SER G  45
THR G  49
 None
U  A1291 ( 4.6A)
None
None
 1.01A 1dvxA-5no4G:
undetectable		 1dvxA-5no4G:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B

(Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG) 		4 LEU B 275
LEU B 277
SER B 283
SER B 278
 None
 1.07A 1dvxA-5odrB:
undetectable		 1dvxA-5odrB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF

(Shewanella
oneidensis) 		no annotation 4 LEU B 168
ALA B 180
SER B  44
SER B  40
 None
 1.03A 1dvxA-5vrfB:
undetectable		 1dvxA-5vrfB:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		5 LEU A 601
ALA A 572
LEU A 570
SER A 488
SER A 490
 None
 0.84A 1dvxA-5w81A:
undetectable		 1dvxA-5w81A:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1

(Homo sapiens) 		PF00514
(Arm) 		4 LEU A 471
ALA A 469
LEU A 467
SER A 422
 None
 1.02A 1dvxA-5xgcA:
undetectable		 1dvxA-5xgcA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn7 PUTATIVE RTX-TOXIN

(Vibrio
vulnificus) 		PF11647
(MLD) 		4 LEU A2427
LEU A2424
SER A2420
THR A2410
 None
 1.01A 1dvxA-5xn7A:
undetectable		 1dvxA-5xn7A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yay KINESIN-LIKE PROTEIN
KIF21A
KN MOTIF AND ANKYRIN
REPEAT DOMAINS 1

(Mus musculus) 		no annotation 4 LEU B1165
ALA A1212
LEU A1210
SER A1177
 None
 0.71A 1dvxA-5yayB:
undetectable		 1dvxA-5yayB:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybv KINESIN-LIKE PROTEIN
KIF21A
KN MOTIF AND ANKYRIN
REPEAT
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		no annotation 4 LEU C1163
ALA A 709
LEU A 707
SER A 674
 None
 0.68A 1dvxA-5ybvC:
undetectable		 1dvxA-5ybvC:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1

(Homo sapiens) 		no annotation 4 LEU A 243
LEU A 233
SER A 222
SER A 224
 None
 0.71A 1dvxA-6b3xA:
undetectable		 1dvxA-6b3xA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		4 LEU A 232
SER A 233
THR B 138
VAL B  16
 None
None
None
NDG  B 273 ( 4.9A)
 0.88A 1dvxB-1abrA:
0.0		 1dvxB-1abrA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ae9 LAMBDA INTEGRASE

(Escherichia
virus Lambda) 		PF00589
(Phage_integrase) 		4 LEU A 180
LEU A 313
SER A 314
VAL A 213
 None
 0.97A 1dvxB-1ae9A:
undetectable		 1dvxB-1ae9A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e12 HALORHODOPSIN

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 LEU A  33
LEU A  81
SER A  82
THR A  85
 None
 1.00A 1dvxB-1e12A:
undetectable		 1dvxB-1e12A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f80 HOLO-(ACYL CARRIER
PROTEIN) SYNTHASE

(Bacillus
subtilis) 		PF01648
(ACPS) 		4 LEU A   7
ALA A 111
SER A 102
THR A 104
 None
None
None
NA  A1255 (-3.8A)
 0.49A 1dvxB-1f80A:
0.0		 1dvxB-1f80A:
24.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		4 LEU A  17
ALA A 108
LEU A 110
SER A 117
 None
 0.72A 1dvxB-1gkeA:
21.1		 1dvxB-1gkeA:
84.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 LEU A  17
ALA A 108
LEU A 110
THR A 119
VAL A 121
 None
 0.37A 1dvxB-1gkeA:
21.1		 1dvxB-1gkeA:
84.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		4 LYS A  15
ALA A 108
THR A 119
VAL A 121
 None
 0.80A 1dvxB-1gkeA:
21.1		 1dvxB-1gkeA:
84.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 LYS A 361
LEU A 357
ALA A 360
THR A 352
 None
 0.76A 1dvxB-1jmyA:
0.0		 1dvxB-1jmyA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1e MYCOLIC ACID
SYNTHASE

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 LEU A 285
SER A 135
THR A 168
VAL A 170
 None
 1.00A 1dvxB-1l1eA:
undetectable		 1dvxB-1l1eA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 4 LYS T 223
LEU T 157
SER T 154
THR T 150
 None
 0.99A 1dvxB-1lthT:
undetectable		 1dvxB-1lthT:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgs PEPTIDE-N(4)-(N-ACET
YL-BETA-D-GLUCOSAMIN
YL)ASPARAGINE
AMIDASE F

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 LEU A 264
LEU A 268
SER A 271
VAL A 312
 None
 0.85A 1dvxB-1pgsA:
1.1		 1dvxB-1pgsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz8 FAB 17B HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  93
SER B  33
THR B  35
VAL B  37
 None
 0.47A 1dvxB-1rz8B:
undetectable		 1dvxB-1rz8B:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.98A 1dvxB-1sb3B:
undetectable		 1dvxB-1sb3B:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ALA B 197
SER B 227
THR B 225
VAL B 223
 None
 0.95A 1dvxB-1skyB:
undetectable		 1dvxB-1skyB:
15.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		5 LEU A  17
ALA A 108
LEU A 110
THR A 119
VAL A 121
 None
 0.43A 1dvxB-1sn2A:
21.6		 1dvxB-1sn2A:
55.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		6 LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
VAL A 121
 None
 0.44A 1dvxB-1tfpA:
19.3		 1dvxB-1tfpA:
74.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE

(Staphylococcus
aureus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LYS A   2
ALA A 170
SER A 315
THR A 317
 None
 0.95A 1dvxB-1tvzA:
undetectable		 1dvxB-1tvzA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uun MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		4 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.60A 1dvxB-1uunA:
3.1		 1dvxB-1uunA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		4 LEU A 735
LEU A 732
THR A 727
VAL A 720
 None
 0.79A 1dvxB-1w8jA:
undetectable		 1dvxB-1w8jA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2

(Infectious
bursal disease
virus) 		PF01766
(Birna_VP2) 		4 ALA J 334
SER J 332
THR J 207
VAL J 205
 None
 0.95A 1dvxB-1wcdJ:
undetectable		 1dvxB-1wcdJ:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1

(Solanum
lycopersicum) 		PF01095
(Pectinesterase) 		4 LEU A 257
SER A 227
THR A 229
VAL A 231
 None
 0.99A 1dvxB-1xg2A:
undetectable		 1dvxB-1xg2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		4 LEU A  90
SER A   8
THR A  34
VAL A  63
 None
 0.99A 1dvxB-1xhlA:
undetectable		 1dvxB-1xhlA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt5 VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3

(Branchiostoma
floridae) 		PF07686
(V-set) 		4 LEU A  94
LEU A  24
THR A   9
VAL A   7
 None
 0.89A 1dvxB-1xt5A:
undetectable		 1dvxB-1xt5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykd ADENYLATE CYCLASE

(Anabaena sp.) 		PF01590
(GAF) 		4 LYS A 200
ALA A 101
LEU A 180
THR A 104
 None
 0.88A 1dvxB-1ykdA:
undetectable		 1dvxB-1ykdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE

(Vibrio
proteolyticus) 		PF04389
(Peptidase_M28) 		4 ALA A 144
SER A 142
THR A  81
VAL A  79
 None
 1.00A 1dvxB-2anpA:
undetectable		 1dvxB-2anpA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bhm TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Brucella suis) 		PF04335
(VirB8) 		4 ALA A 181
SER A 162
THR A 164
VAL A 166
 None
 0.87A 1dvxB-2bhmA:
undetectable		 1dvxB-2bhmA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2i RV0130

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		4 LEU A  91
ALA A 143
THR A 129
VAL A 131
 None
 0.58A 1dvxB-2c2iA:
undetectable		 1dvxB-2c2iA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbe PREDICTED: SIMILAR
TO RET FINGER
PROTEIN-LIKE 1

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 ALA A 113
LEU A 101
SER A  96
THR A 115
 None
 1.02A 1dvxB-2fbeA:
undetectable		 1dvxB-2fbeA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3

(Branchiostoma
floridae) 		PF07686
(V-set) 		4 LEU J  94
LEU J  24
THR J   9
VAL J   7
 None
 0.87A 1dvxB-2fboJ:
undetectable		 1dvxB-2fboJ:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fd5 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 LEU A  73
LEU A  77
SER A  78
VAL A 179
 None
 0.73A 1dvxB-2fd5A:
undetectable		 1dvxB-2fd5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 LEU A  36
ALA A 409
THR A 238
VAL A 235
 None
 0.97A 1dvxB-2iyaA:
undetectable		 1dvxB-2iyaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lyi PROTEIN (ENTITY)

(Nephila
antipodiana) 		PF12042
(RP1-2) 		4 LEU A  43
LEU A 114
SER A 111
VAL A  98
 None
 1.02A 1dvxB-2lyiA:
undetectable		 1dvxB-2lyiA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 125
LEU A 123
THR A  69
VAL A  53
 None
 0.83A 1dvxB-2nqlA:
undetectable		 1dvxB-2nqlA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 125
LEU A 123
THR A  69
VAL A  53
 None
 0.84A 1dvxB-2ppgA:
undetectable		 1dvxB-2ppgA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzi UNCHARACTERIZED
PROTEIN

(Streptococcus
thermophilus) 		PF08860
(DUF1827) 		4 LYS A   2
ALA A  31
THR A  34
VAL A  36
 None
 1.02A 1dvxB-2qziA:
undetectable		 1dvxB-2qziA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rv8 DNA-BINDING RESPONSE
REGULATOR

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C) 		4 LEU A 174
SER A 175
THR A 177
VAL A 202
 None
 0.96A 1dvxB-2rv8A:
undetectable		 1dvxB-2rv8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 LYS G1358
SER G1397
THR G1395
VAL G1393
 None
 0.95A 1dvxB-2uv8G:
undetectable		 1dvxB-2uv8G:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9u MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		4 LEU A  62
ALA A 164
LEU A 166
THR A 176
 LEU  A  62 ( 0.5A)
ALA  A 164 ( 0.0A)
LEU  A 166 ( 0.5A)
THR  A 176 ( 0.8A)
 0.54A 1dvxB-2v9uA:
undetectable		 1dvxB-2v9uA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		4 LEU A  49
ALA A  38
LEU A  51
THR A  34
 None
 0.73A 1dvxB-2w6dA:
undetectable		 1dvxB-2w6dA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ALA A 149
SER A 226
THR A 228
VAL A 230
 None
 0.88A 1dvxB-2yv3A:
undetectable		 1dvxB-2yv3A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zch MONOCLONAL ANTIBODY
8G8F5 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS H 205
ALA H 198
SER H 149
THR H 151
 None
 0.97A 1dvxB-2zchH:
undetectable		 1dvxB-2zchH:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		4 LEU A 243
LEU A 117
SER A 116
VAL A 300
 None
 1.02A 1dvxB-2zm2A:
undetectable		 1dvxB-2zm2A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 LYS A 528
LEU A 526
ALA A 482
VAL A 558
 None
 0.65A 1dvxB-3aqpA:
undetectable		 1dvxB-3aqpA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		4 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.80A 1dvxB-3b8kA:
undetectable		 1dvxB-3b8kA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.80A 1dvxB-3bdwB:
undetectable		 1dvxB-3bdwB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT

(Methanosarcina
barkeri) 		PF02552
(CO_dh)
PF03063
(Prismane) 		4 ALA G 127
LEU G 125
THR A  70
VAL A  68
 ACY  A 821 (-3.6A)
PEG  G 173 ( 4.0A)
None
ACY  A 821 ( 4.3A)
 0.62A 1dvxB-3cf4G:
undetectable		 1dvxB-3cf4G:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Rhodospirillum
rubrum) 		PF00440
(TetR_N) 		4 LEU A 174
ALA A 106
LEU A 102
VAL A  68
 None
 1.02A 1dvxB-3cwrA:
undetectable		 1dvxB-3cwrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX

(Escherichia
coli) 		PF03320
(FBPase_glpX) 		4 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.40A 1dvxB-3d1rA:
undetectable		 1dvxB-3d1rA:
15.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
VAL A 121
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
None
 0.69A 1dvxB-3fc8A:
23.1		 1dvxB-3fc8A:
99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		4 LEU A 173
LEU A 146
SER A 224
THR A 226
 None
 0.66A 1dvxB-3i44A:
undetectable		 1dvxB-3i44A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		4 LEU A 184
LEU A 157
SER A 235
THR A 237
 None
 0.71A 1dvxB-3iwkA:
undetectable		 1dvxB-3iwkA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nib TEG14

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		4 LEU A  86
LEU A 161
THR A 148
VAL A 144
 None
 1.01A 1dvxB-3nibA:
undetectable		 1dvxB-3nibA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oit OS07G0271500 PROTEIN

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ALA A 392
LEU A 394
SER A 250
VAL A 390
 None
 0.85A 1dvxB-3oitA:
undetectable		 1dvxB-3oitA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oit OS07G0271500 PROTEIN

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A 203
ALA A 201
SER A 351
VAL A 139
 None
 0.93A 1dvxB-3oitA:
undetectable		 1dvxB-3oitA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)

(Mycobacterium
tuberculosis) 		PF03602
(Cons_hypoth95) 		4 LEU A  89
LEU A  91
SER A  92
VAL A  47
 None
 0.90A 1dvxB-3p9nA:
undetectable		 1dvxB-3p9nA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU B 280
LEU B 264
SER B 317
THR B 319
 None
 0.67A 1dvxB-3prxB:
3.6		 1dvxB-3prxB:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd5 PUTATIVE
RIBOSE-5-PHOSPHATE
ISOMERASE

(Coccidioides
immitis) 		PF02502
(LacAB_rpiB) 		4 ALA A  12
SER A  38
THR A  40
VAL A  42
 None
 1.02A 1dvxB-3qd5A:
undetectable		 1dvxB-3qd5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00348
(polyprenyl_synt) 		4 LEU A  52
ALA A 183
THR A  67
VAL A 187
 None
 0.90A 1dvxB-3rmgA:
undetectable		 1dvxB-3rmgA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		4 LEU A 264
ALA A 260
LEU A 266
VAL A 248
 None
 0.80A 1dvxB-3si9A:
undetectable		 1dvxB-3si9A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		4 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.72A 1dvxB-3ty7A:
undetectable		 1dvxB-3ty7A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Brucella suis) 		PF04335
(VirB8) 		4 ALA A 181
SER A 162
THR A 164
VAL A 166
 None
 0.93A 1dvxB-4akzA:
undetectable		 1dvxB-4akzA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 4 LEU A  74
SER A  78
THR A  82
VAL A  86
 None
 0.81A 1dvxB-4bb9A:
undetectable		 1dvxB-4bb9A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ALA A  92
LEU A  90
SER A  87
VAL A 156
 None
 1.02A 1dvxB-4bkmA:
undetectable		 1dvxB-4bkmA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 LEU A 250
SER A 226
THR A 224
VAL A 179
 None
 1.02A 1dvxB-4bplA:
undetectable		 1dvxB-4bplA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bva THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE

(Mus musculus) 		PF02423
(OCD_Mu_crystall) 		4 LEU A 138
ALA A 197
SER A 135
VAL A 216
 None
 0.89A 1dvxB-4bvaA:
undetectable		 1dvxB-4bvaA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwi PHYTOCHROME-LIKE
PROTEIN CPH2

(Synechocystis
sp.) 		PF00360
(PHY)
PF01590
(GAF) 		4 LEU A 240
ALA A 225
THR A 221
VAL A 212
 None
 0.98A 1dvxB-4bwiA:
undetectable		 1dvxB-4bwiA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		4 LYS A 613
LEU A 617
LEU A 619
VAL A 694
 None
 0.87A 1dvxB-4c51A:
undetectable		 1dvxB-4c51A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		4 LYS A 295
LEU A 297
LEU A 290
SER A 320
 None
 1.00A 1dvxB-4conA:
undetectable		 1dvxB-4conA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ctd OUTER MEMBRANE
PROTEIN G

(Escherichia
coli) 		PF09381
(Porin_OmpG) 		4 LEU A 167
ALA A 195
LEU A 197
THR A 210
 None
None
None
CL  A1274 (-4.2A)
 0.67A 1dvxB-4ctdA:
undetectable		 1dvxB-4ctdA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493

(Thermus
thermophilus) 		PF02475
(Met_10) 		4 LEU A 259
ALA A 255
LEU A 261
VAL A 225
 None
 1.01A 1dvxB-4dmgA:
undetectable		 1dvxB-4dmgA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnr CHEMOTAXIS PROTEIN
CHEY

(Vibrio cholerae) 		PF00072
(Response_reg) 		4 LEU A  81
ALA A   6
THR A  30
VAL A  28
 None
 0.82A 1dvxB-4hnrA:
undetectable		 1dvxB-4hnrA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		4 LEU A 184
LEU A 157
SER A 235
THR A 237
 None
None
None
NAD  A 601 (-4.2A)
 0.70A 1dvxB-4i8qA:
undetectable		 1dvxB-4i8qA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ki3 OUTER-MEMBRANE
LIPOPROTEIN CARRIER
PROTEIN

(Yersinia pestis) 		PF03548
(LolA) 		4 ALA A 149
SER A 160
THR A 162
VAL A 164
 None
 0.81A 1dvxB-4ki3A:
undetectable		 1dvxB-4ki3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lj2 CHORISMATE SYNTHASE

(Acinetobacter
baumannii) 		PF01264
(Chorismate_synt) 		4 ALA A  25
LEU A  23
THR A  14
VAL A  12
 None
 0.76A 1dvxB-4lj2A:
undetectable		 1dvxB-4lj2A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.83A 1dvxB-4mr0A:
undetectable		 1dvxB-4mr0A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 238
LEU A 240
SER A 241
THR A 244
 None
 0.97A 1dvxB-4mz0A:
undetectable		 1dvxB-4mz0A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhw GLUTATHIONE
S-TRANSFERASE

(Sinorhizobium
meliloti) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ALA A  65
LEU A  62
THR A  74
VAL A  72
 None
GSH  A 301 (-3.7A)
None
None
 1.00A 1dvxB-4nhwA:
undetectable		 1dvxB-4nhwA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5i CHEMOKINE BINDING
PROTEIN

(Orf virus) 		PF02250
(Orthopox_35kD) 		4 LEU A 208
ALA A 145
SER A  82
VAL A  86
 None
None
NAG  A 301 ( 4.9A)
None
 0.83A 1dvxB-4p5iA:
undetectable		 1dvxB-4p5iA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		4 LEU C 413
ALA C 466
LEU C 410
THR C 470
 None
 1.02A 1dvxB-4xgcC:
undetectable		 1dvxB-4xgcC:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 LEU A 380
ALA A 378
SER A 389
THR A 376
 None
 0.95A 1dvxB-4zxiA:
undetectable		 1dvxB-4zxiA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 LEU A 428
ALA A 376
THR A 369
VAL A 365
 None
 1.02A 1dvxB-5a5gA:
undetectable		 1dvxB-5a5gA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dze ENDO-GLUCANASE

(Vitis vinifera) 		PF00722
(Glyco_hydro_16) 		4 LEU A  78
LEU A 166
THR A  51
VAL A 207
 None
 0.95A 1dvxB-5dzeA:
undetectable		 1dvxB-5dzeA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 LEU A 356
LEU A 359
SER A 361
THR A 365
 None
 0.93A 1dvxB-5fsaA:
undetectable		 1dvxB-5fsaA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ALA C 449
SER C 503
THR C 463
VAL C 461
 None
 0.89A 1dvxB-5g5gC:
undetectable		 1dvxB-5g5gC:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk2 KETOSYNTHASE STLD

(Photorhabdus
laumondii) 		PF08541
(ACP_syn_III_C) 		4 ALA A 199
SER A 153
THR A 151
VAL A 149
 None
 0.87A 1dvxB-5gk2A:
undetectable		 1dvxB-5gk2A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h68 CHROMOSOME PARTITION
PROTEIN SMC

(Geobacillus
stearothermophilus) 		PF02463
(SMC_N) 		4 LEU A1086
LEU A1089
SER A1090
VAL A 146
 None
 0.93A 1dvxB-5h68A:
undetectable		 1dvxB-5h68A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR

(Acinetobacter
sp. ADP1) 		PF01614
(IclR) 		4 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 1.02A 1dvxB-5hpiA:
undetectable		 1dvxB-5hpiA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ALA A 197
SER A 227
THR A 225
VAL A 223
 None
 0.82A 1dvxB-5ik2A:
undetectable		 1dvxB-5ik2A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvf SITE-DETERMINING
PROTEIN

(Pseudomonas
aeruginosa) 		PF10609
(ParA) 		4 ALA A  47
LEU A  49
THR A 128
VAL A 126
 None
 0.92A 1dvxB-5jvfA:
undetectable		 1dvxB-5jvfA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		4 LYS A 620
LEU A 624
LEU A 626
VAL A 702
 None
 0.93A 1dvxB-5kqiA:
undetectable		 1dvxB-5kqiA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		4 ALA A 243
SER A 273
THR A 271
VAL A 269
 None
 0.86A 1dvxB-5l2pA:
undetectable		 1dvxB-5l2pA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nst HEAVY CHAIN OF
ANTIBODY MGD21

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF13895
(Ig_2) 		4 LEU B 144
SER B 153
THR B 155
VAL B 158
 None
 1.01A 1dvxB-5nstB:
undetectable		 1dvxB-5nstB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocp -

(-) 		no annotation 4 LEU A 218
ALA A 239
THR A 277
VAL A 275
 None
 1.02A 1dvxB-5ocpA:
undetectable		 1dvxB-5ocpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF13561
(adh_short_C2) 		4 LEU A  85
SER A   9
THR A  35
VAL A  62
 None
 0.88A 1dvxB-5va8A:
undetectable		 1dvxB-5va8A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w42 -

(-) 		no annotation 4 ALA H  93
SER H  33
THR H  35
VAL H  37
 None
 0.42A 1dvxB-5w42H:
undetectable		 1dvxB-5w42H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 LEU A 601
ALA A 572
LEU A 570
SER A 490
 None
 0.84A 1dvxB-5w81A:
undetectable		 1dvxB-5w81A:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn7 PUTATIVE RTX-TOXIN

(Vibrio
vulnificus) 		PF11647
(MLD) 		4 LEU A2427
LEU A2424
SER A2420
THR A2410
 None
 0.98A 1dvxB-5xn7A:
undetectable		 1dvxB-5xn7A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yiv CELL CYCLE
REGULATORY PROTEIN
GCRA

(Caulobacter
vibrioides) 		no annotation 4 LEU A  14
LEU A  19
SER A  20
VAL A  31
 None
 0.98A 1dvxB-5yivA:
undetectable		 1dvxB-5yivA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amw TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		4 LEU A 214
LEU A 141
SER A 140
VAL A 151
 None
 1.02A 1dvxB-6amwA:
undetectable		 1dvxB-6amwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 4 LEU A 166
ALA A 169
LEU A 165
VAL A 158
 None
None
SAH  A 305 ( 4.6A)
None
 1.02A 1dvxB-6b92A:
undetectable		 1dvxB-6b92A:
18.69