SIMILAR PATTERNS OF AMINO ACIDS FOR 1DTL_A_BEPA205_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 ALA A 250
PHE A 533
LEU A 538
LEU A 255
MET A 152
 None
 1.13A 1dtlA-1c0aA:
0.1		 1dtlA-1c0aA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecx AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00266
(Aminotran_5) 		5 ALA A 281
LEU A 366
PHE A 365
LEU A 311
LEU A 307
 None
 1.16A 1dtlA-1ecxA:
undetectable		 1dtlA-1ecxA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		5 ILE A 288
PHE A 296
LEU A 232
MET A 236
LEU A  88
 None
 1.12A 1dtlA-1hvyA:
undetectable		 1dtlA-1hvyA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		5 ALA A 278
ILE A 378
LEU A 122
LEU A 126
PHE A 297
 None
 1.19A 1dtlA-1js6A:
undetectable		 1dtlA-1js6A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		5 ALA A 232
ILE A 235
LEU A 277
LEU A 184
LEU A 250
 None
 1.12A 1dtlA-1l1lA:
0.0		 1dtlA-1l1lA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 ILE A 672
PHE A 536
LEU A 579
PHE A 574
LEU A 562
 None
 1.07A 1dtlA-1l5jA:
undetectable		 1dtlA-1l5jA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ln1 PHOSPHATIDYLCHOLINE
TRANSFER PROTEIN

(Homo sapiens) 		PF01852
(START) 		5 ILE A  71
PHE A 199
LEU A 200
MET A 203
MET A 173
 None
DLP  A2313 (-3.4A)
None
DLP  A2313 (-4.2A)
DLP  A2313 (-4.2A)
 1.09A 1dtlA-1ln1A:
undetectable		 1dtlA-1ln1A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw7 HYPOTHETICAL PROTEIN
HP0162

(Helicobacter
pylori) 		PF01709
(Transcrip_reg) 		5 ILE A 174
LEU A 194
PHE A 189
LEU A 185
LEU A 163
 None
 1.18A 1dtlA-1mw7A:
0.6		 1dtlA-1mw7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN

(Phaseolus
vulgaris) 		PF08263
(LRRNT_2) 		5 ILE A 181
PHE A 156
LEU A 151
PHE A 176
LEU A 197
 None
 0.94A 1dtlA-1ogqA:
undetectable		 1dtlA-1ogqA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pff METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		5 ALA A 313
ILE A 312
PHE A 314
LEU A 327
LEU A 339
 None
 1.20A 1dtlA-1pffA:
undetectable		 1dtlA-1pffA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh1 COLICIN B

(Escherichia
coli) 		PF01024
(Colicin)
PF03515
(Cloacin) 		5 ALA A 492
ILE A 373
PHE A 464
LEU A 382
MET A 377
 None
 1.00A 1dtlA-1rh1A:
0.0		 1dtlA-1rh1A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg6 HYPOTHETICAL PROTEIN
(RIKEN CDNA
2810455B10)

(Mus musculus) 		PF00595
(PDZ) 		5 ALA A  68
ILE A  62
LEU A  80
LEU A 116
MET A 104
 None
 1.02A 1dtlA-1wg6A:
undetectable		 1dtlA-1wg6A:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES

(Homo sapiens) 		PF13833
(EF-hand_8) 		5 ALA A  23
ILE A  26
PHE A  77
MET A  81
LEU A  48
 TFP  A 204 ( 4.7A)
None
None
TFP  A 202 ( 3.3A)
TFP  A 202 (-4.1A)
 0.71A 1dtlA-1wrkA:
14.4		 1dtlA-1wrkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y81 CONSERVED
HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF13380
(CoA_binding_2) 		5 ALA A  84
PHE A 103
LEU A 104
LEU A  89
PHE A  67
 None
 1.08A 1dtlA-1y81A:
undetectable		 1dtlA-1y81A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 ALA A 248
LEU A 207
MET A 211
LEU A 194
MET A 186
 None
 1.19A 1dtlA-1zg4A:
undetectable		 1dtlA-1zg4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmr PHOSPHOGLYCERATE
KINASE

(Escherichia
coli) 		PF00162
(PGK) 		5 ALA A 187
LEU A 367
PHE A 366
LEU A 174
LEU A 178
 None
 1.15A 1dtlA-1zmrA:
undetectable		 1dtlA-1zmrA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		5 ALA I  86
ILE I  83
PHE I 344
LEU I 340
LEU I 102
 None
 1.15A 1dtlA-2b4xI:
undetectable		 1dtlA-2b4xI:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 ILE A 669
PHE A 640
LEU A 606
LEU A 654
PHE A 674
 None
 1.21A 1dtlA-2c9kA:
undetectable		 1dtlA-2c9kA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		5 ALA X  14
LEU X  31
PHE X   4
LEU X  24
LEU X  22
 None
 1.19A 1dtlA-2epkX:
undetectable		 1dtlA-2epkX:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f02 TAGATOSE-6-PHOSPHATE
KINASE

(Enterococcus
faecalis) 		PF00294
(PfkB) 		5 PHE A 197
LEU A 209
PHE A 214
LEU A 173
LEU A 169
 None
 1.17A 1dtlA-2f02A:
undetectable		 1dtlA-2f02A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb4 THIOPURINE
S-METHYLTRANSFERASE

(Mus musculus) 		PF05724
(TPMT) 		5 ALA A  68
ILE A  69
PHE A  94
LEU A  48
LEU A  44
 SAH  A 300 ( 4.4A)
None
None
None
None
 1.11A 1dtlA-2gb4A:
undetectable		 1dtlA-2gb4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350

(Human
gammaherpesvirus
4) 		PF05109
(Herpes_BLLF1) 		5 ILE A 230
PHE A 228
PHE A 196
LEU A 179
LEU A 281
 None
 1.19A 1dtlA-2h6oA:
undetectable		 1dtlA-2h6oA:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1

(Saccharomyces
cerevisiae;
synthetic
construct) 		PF13499
(EF-hand_7) 		5 ALA A  15
PHE A  19
PHE A  68
MET A  72
LEU A 109
 None
 1.14A 1dtlA-2lhiA:
12.5		 1dtlA-2lhiA:
34.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lmv CALMODULIN-RELATED
PROTEIN 97A

(Drosophila
melanogaster) 		PF13499
(EF-hand_7) 		5 ALA A  88
ILE A  91
PHE A  92
PHE A 141
LEU A   4
 None
 0.87A 1dtlA-2lmvA:
8.5		 1dtlA-2lmvA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n7l TROPONIN C/TROPONIN
I CHIMERA

(Homo sapiens) 		PF13833
(EF-hand_8) 		5 ALA C  23
ILE C  26
PHE C  27
MET C  81
LEU C 111
 None
None
None
4J4  C  84 ( 4.7A)
None
 0.92A 1dtlA-2n7lC:
9.9		 1dtlA-2n7lC:
56.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		5 LEU A 264
PHE A 253
LEU A 251
LEU A 247
MET A 117
 None
 1.18A 1dtlA-2pn1A:
undetectable		 1dtlA-2pn1A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		5 ALA A 262
ILE A 260
PHE A 229
LEU A 301
LEU A 282
 None
 1.17A 1dtlA-2q6zA:
undetectable		 1dtlA-2q6zA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rh7 GREEN FLUORESCENT
PROTEIN

(Renilla
reniformis) 		PF01353
(GFP) 		5 ALA A  64
PHE A 124
MET A  29
PHE A 165
LEU A 200
 None
None
None
None
CRO  A  66 ( 4.2A)
 1.19A 1dtlA-2rh7A:
undetectable		 1dtlA-2rh7A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN

(Halomonas
elongata) 		PF03480
(DctP) 		5 ILE A 100
PHE A  94
LEU A 107
LEU A 299
PHE A 288
 None
 1.19A 1dtlA-2vpnA:
undetectable		 1dtlA-2vpnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		5 ALA A 695
PHE A 684
PHE A 654
PHE A 632
LEU A 672
 None
 1.08A 1dtlA-2x6kA:
undetectable		 1dtlA-2x6kA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A  90
PHE A 159
LEU A  41
LEU A 243
LEU A 238
 None
 1.21A 1dtlA-3a9vA:
undetectable		 1dtlA-3a9vA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjs 50S RIBOSOMAL
PROTEIN L11
RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF03946
(Ribosomal_L11_N)
no annotation 		5 PHE B  41
PHE B  37
PHE A  21
LEU A  17
LEU A  10
 None
 1.09A 1dtlA-3cjsB:
undetectable		 1dtlA-3cjsB:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebt UNCHARACTERIZED
NTF2-LIKE PROTEIN

(Burkholderia
pseudomallei) 		PF12680
(SnoaL_2) 		5 ILE A  65
PHE A  15
LEU A  70
MET A  68
PHE A 116
 None
UNL  A 133 ( 4.4A)
UNL  A 133 (-4.9A)
UNL  A 132 ( 3.9A)
UNL  A 133 (-4.8A)
 1.04A 1dtlA-3ebtA:
undetectable		 1dtlA-3ebtA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3er6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN

(Vibrio
parahaemolyticus) 		PF01965
(DJ-1_PfpI) 		5 ALA A 113
ILE A  80
LEU A  90
PHE A 142
MET A 134
 None
 1.05A 1dtlA-3er6A:
undetectable		 1dtlA-3er6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 195
PHE A 165
LEU A 182
LEU A 180
PHE A 171
 None
 1.13A 1dtlA-3fxiA:
undetectable		 1dtlA-3fxiA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l CYTOCHROME B

(Gallus gallus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		6 ALA C 278
ILE C 281
MET C 125
LEU C 302
LEU C 329
LEU C 333
 3H1  C2001 ( 3.7A)
None
3H1  C2001 ( 4.7A)
HEM  C 502 ( 4.9A)
None
PEE  C2007 ( 4.0A)
 1.22A 1dtlA-3h1lC:
undetectable		 1dtlA-3h1lC:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		5 LEU A 271
LEU A 421
MET A 266
LEU A 383
MET A 434
 None
 1.15A 1dtlA-3hvdA:
undetectable		 1dtlA-3hvdA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 ALA A 154
ILE A 153
LEU A 172
LEU A 253
PHE A 182
 None
 1.18A 1dtlA-3ju1A:
undetectable		 1dtlA-3ju1A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		5 ALA A  62
LEU A 340
PHE A 344
LEU A 305
LEU A  71
 None
 1.16A 1dtlA-3m1uA:
undetectable		 1dtlA-3m1uA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ni8 PFC0360W PROTEIN

(Plasmodium
falciparum) 		PF08327
(AHSA1) 		5 ILE A  83
PHE A  74
LEU A  65
PHE A 144
LEU A 116
 None
None
None
IPA  A 159 ( 4.8A)
None
 1.05A 1dtlA-3ni8A:
undetectable		 1dtlA-3ni8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 ILE A 369
LEU A 437
PHE A 422
MET A 381
LEU A 399
 None
 1.17A 1dtlA-3oksA:
undetectable		 1dtlA-3oksA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Listeria
monocytogenes) 		PF00275
(EPSP_synthase) 		5 ALA A 236
ILE A 252
LEU A 378
LEU A 267
LEU A 263
 None
 1.12A 1dtlA-3r38A:
undetectable		 1dtlA-3r38A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6k VP1 PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		5 ALA A 484
ILE A 470
MET A 525
LEU A 249
PHE A 429
 None
 1.02A 1dtlA-3r6kA:
undetectable		 1dtlA-3r6kA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K

(Escherichia
coli) 		no annotation 5 ALA J  12
ILE J  13
PHE J   5
LEU K  44
PHE J  43
 None
 1.17A 1dtlA-3rkoJ:
undetectable		 1dtlA-3rkoJ:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 ILE N 269
PHE N 207
LEU N 316
LEU N 313
PHE N 251
 None
 1.19A 1dtlA-3rkoN:
undetectable		 1dtlA-3rkoN:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t58 SULFHYDRYL OXIDASE 1

(Mus musculus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		5 ALA A 188
PHE A 183
PHE A 182
LEU A 242
LEU A 272
 None
 1.09A 1dtlA-3t58A:
undetectable		 1dtlA-3t58A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		5 ILE A  67
PHE A  68
LEU A  80
LEU A 285
PHE A 126
 None
 0.84A 1dtlA-3tsyA:
undetectable		 1dtlA-3tsyA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uow GMP SYNTHETASE

(Plasmodium
falciparum) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 PHE A 181
LEU A  79
PHE A  75
LEU A  70
LEU A  55
 None
 1.08A 1dtlA-3uowA:
undetectable		 1dtlA-3uowA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vup BETA-1,4-MANNANASE

(Aplysia kurodai) 		PF00150
(Cellulase) 		5 ALA A 319
PHE A 308
PHE A 294
LEU A  51
PHE A 107
 None
 1.08A 1dtlA-3vupA:
undetectable		 1dtlA-3vupA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zri CLPB PROTEIN

(Vibrio cholerae) 		PF02861
(Clp_N) 		5 ALA A 115
PHE A 148
LEU A  45
LEU A  91
LEU A  95
 None
 1.12A 1dtlA-3zriA:
undetectable		 1dtlA-3zriA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6j PHOSPHOSERINE
PHOSPHATASE

(Thermococcus
onnurineus) 		PF12710
(HAD) 		5 ALA A 117
ILE A 118
PHE A 124
PHE A  64
LEU A  49
 None
 0.92A 1dtlA-4b6jA:
undetectable		 1dtlA-4b6jA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ALA A 288
ILE A 353
PHE A 375
LEU A 361
LEU A 266
 None
 1.19A 1dtlA-4bziA:
1.5		 1dtlA-4bziA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cca SYNTAXIN-BINDING
PROTEIN 2

(Homo sapiens) 		PF00995
(Sec1) 		5 ALA A 202
ILE A 232
LEU A 156
MET A 539
LEU A 169
 None
 1.09A 1dtlA-4ccaA:
undetectable		 1dtlA-4ccaA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 ILE A 374
LEU A 427
PHE A 408
LEU A 382
LEU A 368
 None
 1.01A 1dtlA-4cp6A:
undetectable		 1dtlA-4cp6A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		5 ALA A 185
ILE A  81
PHE A 182
LEU A 150
LEU A 188
 None
 1.16A 1dtlA-4e7wA:
undetectable		 1dtlA-4e7wA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flc ADENYLOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 ALA A 127
ILE A 123
PHE A  30
LEU A 252
LEU A 193
 None
 1.15A 1dtlA-4flcA:
undetectable		 1dtlA-4flcA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4geq KINETOCHORE PROTEIN
SPC24
KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae) 		PF08286
(Spc24)
no annotation 		5 ALA A 213
ILE A 171
PHE A 163
LEU B 164
LEU A 200
 None
 1.13A 1dtlA-4geqA:
undetectable		 1dtlA-4geqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 ALA A  99
ILE A 122
PHE A  95
LEU A 326
LEU A 322
 None
 1.19A 1dtlA-4grsA:
undetectable		 1dtlA-4grsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hva CASPASE-6

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 ILE A 159
LEU A 286
PHE A 288
LEU A  81
LEU A 236
 None
 1.19A 1dtlA-4hvaA:
undetectable		 1dtlA-4hvaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilg A1 CISTRON-SPLICING
FACTOR AAR2

(Saccharomyces
cerevisiae) 		PF05282
(AAR2) 		5 PHE A 183
MET A 209
LEU A 268
LEU A 264
PHE A 221
 None
 1.13A 1dtlA-4ilgA:
undetectable		 1dtlA-4ilgA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ily CHITOSANASE

(Streptomyces
sp. SirexAA-E) 		PF01374
(Glyco_hydro_46) 		5 ALA A 198
ILE A 214
PHE A 211
LEU A 187
LEU A 239
 None
 1.16A 1dtlA-4ilyA:
undetectable		 1dtlA-4ilyA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6j WINGS APART-LIKE
PROTEIN HOMOLOG

(Homo sapiens) 		PF07814
(WAPL) 		5 ALA A 682
ILE A 726
LEU A 707
PHE A 704
LEU A 694
 None
 1.09A 1dtlA-4k6jA:
undetectable		 1dtlA-4k6jA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzl RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg) 		5 ILE A 117
PHE A 118
LEU A  22
LEU A  80
MET A  78
 None
 1.03A 1dtlA-4lzlA:
undetectable		 1dtlA-4lzlA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 PHE A 349
PHE A 454
LEU A 467
LEU A 488
MET A 509
 None
 1.13A 1dtlA-4mvfA:
9.2		 1dtlA-4mvfA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q00 FERROUS IRON
TRANSPORT PROTEIN B

(Escherichia
coli) 		PF02421
(FeoB_N) 		5 ALA A 118
ILE A 116
PHE A  45
LEU A  54
LEU A   8
 None
 1.11A 1dtlA-4q00A:
undetectable		 1dtlA-4q00A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpd CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		6 ALA A 484
ILE A 470
MET A 525
LEU A 249
PHE A 429
LEU A 448
 None
 1.38A 1dtlA-4rpdA:
undetectable		 1dtlA-4rpdA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ums CELLULOSOMAL
ANCHORING SCAFFOLDIN
B

(Pseudobacteroides
cellulosolvens) 		PF00963
(Cohesin) 		6 ALA A1134
ILE A1061
PHE A1115
PHE A1103
LEU A1087
PHE A1138
 None
 1.12A 1dtlA-4umsA:
undetectable		 1dtlA-4umsA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 ALA A 270
ILE A 269
LEU A  48
PHE A 208
LEU A 204
 None
 1.04A 1dtlA-4us4A:
undetectable		 1dtlA-4us4A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 ALA A 366
LEU A 131
LEU A 400
LEU A 252
MET A 374
 None
 1.18A 1dtlA-4wpzA:
undetectable		 1dtlA-4wpzA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 PHE A 503
LEU A 395
LEU A 376
LEU A 332
PHE A 360
 None
 1.14A 1dtlA-4z64A:
undetectable		 1dtlA-4z64A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2

(Homo sapiens) 		PF00043
(GST_C) 		5 ALA B 214
ILE B 213
LEU B 183
LEU B 142
PHE B 221
 None
None
None
None
GOL  B1321 (-3.8A)
 1.01A 1dtlA-5a1nB:
undetectable		 1dtlA-5a1nB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00043
(GST_C) 		5 ILE B 213
LEU A  72
LEU B 183
LEU B 142
PHE B 221
 None
None
None
None
GOL  B1321 (-3.8A)
 1.04A 1dtlA-5a1nB:
undetectable		 1dtlA-5a1nB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis) 		PF00303
(Thymidylat_synt) 		5 ILE A 282
PHE A 290
LEU A 226
MET A 230
LEU A  82
 None
 1.14A 1dtlA-5by6A:
undetectable		 1dtlA-5by6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF13476
(AAA_23) 		5 ILE A1259
PHE A1279
LEU A1280
MET A1283
LEU A  31
 None
 1.21A 1dtlA-5dacA:
undetectable		 1dtlA-5dacA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 PHE A 178
MET A 200
PHE A 236
LEU A 233
MET A 174
 None
 1.16A 1dtlA-5e5uA:
undetectable		 1dtlA-5e5uA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghf AMINOTRANSFERASE
CLASS-III

(Ochrobactrum
anthropi) 		PF00202
(Aminotran_3) 		5 ALA A 112
PHE A 114
LEU A 339
PHE A 264
MET A 285
 None
 1.00A 1dtlA-5ghfA:
undetectable		 1dtlA-5ghfA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2

(Arabidopsis
thaliana) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 ALA A 483
LEU A 380
PHE A 378
LEU A 403
LEU A 370
 None
 1.15A 1dtlA-5gxuA:
undetectable		 1dtlA-5gxuA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2

(Arabidopsis
thaliana) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 LEU A 380
PHE A 378
LEU A 403
LEU A 407
PHE A 478
 None
 1.19A 1dtlA-5gxuA:
undetectable		 1dtlA-5gxuA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hi9 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF12796
(Ank_2) 		5 ALA A 217
ILE A 172
MET A 270
LEU A 230
LEU A 212
 None
 1.17A 1dtlA-5hi9A:
undetectable		 1dtlA-5hi9A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		5 ALA A 247
ILE A 242
PHE A 240
PHE A 249
LEU A 215
 None
 1.16A 1dtlA-5kjaA:
undetectable		 1dtlA-5kjaA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA

(Homo sapiens) 		PF08311
(Mad3_BUB1_I) 		5 ALA S 171
ILE S 174
PHE S 175
PHE S 196
LEU S 136
 None
 1.19A 1dtlA-5lcwS:
undetectable		 1dtlA-5lcwS:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxr RNA-BINDING PROTEIN
7
ZINC FINGER CCHC
DOMAIN-CONTAINING
PROTEIN 8

(Homo sapiens) 		PF00076
(RRM_1)
PF04046
(PSP) 		5 PHE B 286
LEU A  69
PHE B 309
LEU B 299
LEU B 295
 None
 1.17A 1dtlA-5lxrB:
undetectable		 1dtlA-5lxrB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B

(Bos taurus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		6 ALA C 277
ILE C 280
MET C 124
LEU C 301
LEU C 328
LEU C 332
 None
None
None
HEM  C 502 ( 4.8A)
None
None
 1.21A 1dtlA-5nmiC:
undetectable		 1dtlA-5nmiC:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn7 URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
8) 		no annotation 5 ILE A  80
PHE A 184
LEU A  27
LEU A  35
PHE A 170
 None
 1.19A 1dtlA-5nn7A:
undetectable		 1dtlA-5nn7A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsj PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Whitewater
Arroyo
mammarenavirus) 		no annotation 5 ALA A 173
LEU A 140
LEU A 106
PHE A 147
MET A 144
 None
 0.89A 1dtlA-5nsjA:
undetectable		 1dtlA-5nsjA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 ILE T1511
LEU T1463
PHE T1445
LEU T1477
LEU T1473
 None
 1.14A 1dtlA-5ojsT:
undetectable		 1dtlA-5ojsT:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ILE A 585
PHE A 593
LEU A 527
MET A 531
LEU A 382
 None
 1.14A 1dtlA-5t0lA:
undetectable		 1dtlA-5t0lA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 5 ILE A 158
PHE A 162
LEU A 255
LEU A 249
MET A 242
 None
OAQ  A 302 (-4.6A)
None
None
OAQ  A 302 ( 4.0A)
 1.20A 1dtlA-5tiwA:
undetectable		 1dtlA-5tiwA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfa RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		no annotation 5 ILE A 117
PHE A 118
LEU A  22
LEU A  80
MET A  78
 None
 1.18A 1dtlA-5vfaA:
undetectable		 1dtlA-5vfaA:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w88 TROPONIN C, TROPONIN
I

(Homo sapiens) 		PF00992
(Troponin)
PF13833
(EF-hand_8) 		5 ALA A  23
ILE A  26
PHE A  77
MET A  81
LEU A  48
 None
None
9XG  A 201 (-3.8A)
9XG  A 201 ( 4.6A)
9XG  A 201 ( 4.8A)
 1.19A 1dtlA-5w88A:
10.7		 1dtlA-5w88A:
65.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13

(Homo sapiens) 		PF01564
(Spermine_synth) 		5 ALA A 479
PHE A 651
LEU A 507
LEU A 676
PHE A 515
 None
 1.11A 1dtlA-5wcjA:
undetectable		 1dtlA-5wcjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 5 ILE A 663
MET A 572
LEU A 612
PHE A 722
LEU A 718
 None
 1.21A 1dtlA-5x3jA:
undetectable		 1dtlA-5x3jA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7l TSRD

(Streptomyces
laurentii) 		no annotation 5 ALA A  50
LEU A  61
PHE A  81
LEU A 103
PHE A  13
 None
None
IPA  A 201 ( 3.6A)
IPA  A 201 ( 4.8A)
None
 1.14A 1dtlA-5x7lA:
undetectable		 1dtlA-5x7lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases) 		5 ALA D 458
PHE D 226
LEU D 225
LEU D 136
PHE D 140
 None
 1.17A 1dtlA-5xfaD:
undetectable		 1dtlA-5xfaD:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 5 ILE A 472
PHE A 523
PHE A 256
PHE A 388
LEU A 436
 None
 1.20A 1dtlA-5xixA:
0.2		 1dtlA-5xixA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E

(Staphylococcus
aureus) 		no annotation 5 ALA A 109
ILE A 112
PHE A 298
LEU A 277
LEU A   7
 None
 1.17A 1dtlA-5xoeA:
undetectable		 1dtlA-5xoeA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3

(Yarrowia
lipolytica) 		no annotation 5 ILE A  38
PHE A  36
LEU A 359
LEU A 639
PHE A 314
 None
 1.01A 1dtlA-5ys9A:
undetectable		 1dtlA-5ys9A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zi9 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Streptomyces
coelicolor) 		no annotation 5 ALA A 167
PHE A 170
PHE A 198
LEU A 151
LEU A  68
 None
 1.11A 1dtlA-5zi9A:
undetectable		 1dtlA-5zi9A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 240
PHE A 260
LEU A 221
LEU A 217
MET A 272
 None
 1.10A 1dtlA-6asoA:
undetectable		 1dtlA-6asoA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdz THYMIDYLATE SYNTHASE

(Escherichia
coli) 		no annotation 5 ILE A 239
PHE A 247
LEU A 183
MET A 187
LEU A  59
 None
 1.14A 1dtlA-6cdzA:
undetectable		 1dtlA-6cdzA:
21.60