SIMILAR PATTERNS OF AMINO ACIDS FOR 1DSC_C_DVAC8_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aun | PR-5D (Nicotianatabacum) |
PF00314(Thaumatin) | 3 | THR A 188THR A 190PRO A 187 | None | 0.67A | 1dscC-1aunA:undetectable | 1dscC-1aunA:4.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhg | BETA-GLUCURONIDASE (Homo sapiens) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 3 | THR A 223THR A 117PRO A 224 | None | 0.72A | 1dscC-1bhgA:undetectable | 1dscC-1bhgA:4.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cpt | CYTOCHROME P450-TERP (Pseudomonas sp.) |
PF00067(p450) | 3 | THR A 109THR A 111PRO A 108 | None | 0.82A | 1dscC-1cptA:undetectable | 1dscC-1cptA:5.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cpt | CYTOCHROME P450-TERP (Pseudomonas sp.) |
PF00067(p450) | 3 | THR A 111THR A 109PRO A 107 | None | 0.73A | 1dscC-1cptA:undetectable | 1dscC-1cptA:5.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eg1 | ENDOGLUCANASE I (Trichodermareesei) |
PF00840(Glyco_hydro_7) | 3 | THR A 7THR A 5PRO A 8 | None | 0.70A | 1dscC-1eg1A:undetectable | 1dscC-1eg1A:4.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eu1 | DIMETHYL SULFOXIDEREDUCTASE (Rhodobactersphaeroides) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 3 | THR A 107THR A 109PRO A 106 | None | 0.73A | 1dscC-1eu1A:undetectable | 1dscC-1eu1A:1.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ffv | CUTL, MOLYBDOPROTEINOF CARBON MONOXIDEDEHYDROGENASE (Hydrogenophagapseudoflava) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 3 | THR B 766THR B 768PRO B 765 | None | 0.70A | 1dscC-1ffvB:undetectable | 1dscC-1ffvB:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g7c | ELONGATION FACTOR1-ALPHA (Saccharomycescerevisiae) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 3 | THR A 267THR A 240PRO A 239 | None | 0.83A | 1dscC-1g7cA:undetectable | 1dscC-1g7cA:6.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gom | ENDO-1,4-BETA-XYLANASE (Thermoascusaurantiacus) |
PF00331(Glyco_hydro_10) | 3 | THR A 44THR A 22PRO A 45 | None | 0.79A | 1dscC-1gomA:undetectable | 1dscC-1gomA:3.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3e | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 3 | THR A 70THR A 84PRO A 72 | None | 0.80A | 1dscC-1j3eA:undetectable | 1dscC-1j3eA:9.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3u | ASPARTASE (Bacillus sp.YM55-1) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 3 | THR A 147THR A 149PRO A 146 | None | 0.72A | 1dscC-1j3uA:undetectable | 1dscC-1j3uA:2.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j83 | ENDO-1,4-BETAGLUCANASE ENGF (Clostridiumcellulovorans) |
PF03424(CBM_17_28) | 3 | THR A1118THR A1156PRO A1117 | None | 0.83A | 1dscC-1j83A:undetectable | 1dscC-1j83A:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jio | CYTOCHROME P450107A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 3 | THR A 99THR A 97PRO A 95 | None | 0.78A | 1dscC-1jioA:undetectable | 1dscC-1jioA:7.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k9x | M32 CARBOXYPEPTIDASE (Pyrococcusfuriosus) |
PF02074(Peptidase_M32) | 3 | THR A 422THR A 424PRO A 421 | None | 0.81A | 1dscC-1k9xA:undetectable | 1dscC-1k9xA:3.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kj0 | SERINE PROTEASEINHIBITOR I (Schistocercagregaria) |
PF05375(Pacifastin_I) | 3 | THR A 20THR A 5PRO A 21 | None | 0.67A | 1dscC-1kj0A:undetectable | 1dscC-1kj0A:38.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrr | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 3 | THR A 135THR A 149PRO A 137 | None | 0.76A | 1dscC-1lrrA:undetectable | 1dscC-1lrrA:6.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m64 | FLAVOCYTOCHROME C3 (Shewanellafrigidimarina) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 3 | THR A 500THR A 367PRO A 501 | None | 0.84A | 1dscC-1m64A:undetectable | 1dscC-1m64A:2.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ml4 | ASPARTATETRANSCARBAMOYLASE (Pyrococcusabyssi) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 137THR A 139PRO A 136 | None | 0.71A | 1dscC-1ml4A:undetectable | 1dscC-1ml4A:3.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nwa | PEPTIDE METHIONINESULFOXIDE REDUCTASEMSRA (Mycobacteriumtuberculosis) |
PF01625(PMSR) | 3 | THR A 61THR A 63PRO A 60 | None | 0.59A | 1dscC-1nwaA:undetectable | 1dscC-1nwaA:7.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pcv | OSMOTIN (Nicotianatabacum) |
PF00314(Thaumatin) | 3 | THR A 187THR A 189PRO A 186 | None | 0.77A | 1dscC-1pcvA:undetectable | 1dscC-1pcvA:5.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ux6 | THROMBOSPONDIN-1 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 3 | THR A1035THR A1032PRO A1034 | None | 0.70A | 1dscC-1ux6A:undetectable | 1dscC-1ux6A:4.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlr | COAGULATION FACTORXI (Homo sapiens) |
PF00089(Trypsin) | 3 | THR A 37THR A 36PRO A 37 | None | 0.75A | 1dscC-1zlrA:undetectable | 1dscC-1zlrA:4.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zrt | CYTOCHROME B (Rhodobactercapsulatus) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 3 | THR C 241THR C 37PRO C 36 | None | 0.84A | 1dscC-1zrtC:undetectable | 1dscC-1zrtC:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zwt | MAJOR STRUCTURALSUBUNIT OFBUNDLE-FORMING PILUS (Escherichiacoli) |
PF05307(Bundlin) | 3 | THR A 136THR A 99PRO A 137 | None | 0.84A | 1dscC-1zwtA:undetectable | 1dscC-1zwtA:14.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ad1 | SULFOTRANSFERASE 1C2 (Homo sapiens) |
PF00685(Sulfotransfer_1) | 3 | THR A 25THR A 23PRO A 22 | None | 0.82A | 1dscC-2ad1A:undetectable | 1dscC-2ad1A:4.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2be7 | ASPARTATECARBAMOYLTRANSFERASECATALYTIC CHAIN (Moritellaprofunda) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 136THR A 138PRO A 135 | None | 0.76A | 1dscC-2be7A:undetectable | 1dscC-2be7A:3.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f5v | PYRANOSE 2-OXIDASE (Peniophora sp.SG) |
PF05199(GMC_oxred_C) | 3 | THR A 595THR A 597PRO A 594 | FAD A1625 (-3.4A)NoneFAD A1625 ( 4.4A) | 0.83A | 1dscC-2f5vA:undetectable | 1dscC-2f5vA:2.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hxr | HTH-TYPETRANSCRIPTIONALREGULATOR CYNR (Escherichiacoli) |
PF03466(LysR_substrate) | 3 | THR A 100THR A 102PRO A 99 | None | 0.84A | 1dscC-2hxrA:undetectable | 1dscC-2hxrA:2.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ljp | RIBONUCLEASE PPROTEIN COMPONENT (Escherichiacoli) |
PF00825(Ribonuclease_P) | 3 | THR A 30THR A 34PRO A 31 | None | 0.75A | 1dscC-2ljpA:undetectable | 1dscC-2ljpA:8.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oce | HYPOTHETICAL PROTEINPA5201 (Pseudomonasaeruginosa) |
PF00575(S1)PF09371(Tex_N)PF12836(HHH_3)PF16921(Tex_YqgF) | 3 | THR A 618THR A 620PRO A 617 | None | 0.74A | 1dscC-2oceA:undetectable | 1dscC-2oceA:2.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rgw | ASPARTATECARBAMOYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 133THR A 135PRO A 132 | None | 0.78A | 1dscC-2rgwA:undetectable | 1dscC-2rgwA:3.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7z | HEAT SHOCK COGNATE71 KDA PROTEIN (Rattusnorvegicus) |
PF00012(HSP70) | 3 | THR A 64THR A 66PRO A 63 | None | 0.75A | 1dscC-2v7zA:undetectable | 1dscC-2v7zA:3.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9q | ROUNDABOUT HOMOLOG 1 (Homo sapiens) |
PF07679(I-set)PF13927(Ig_3) | 3 | THR A 228THR A 230PRO A 186 | None | 0.82A | 1dscC-2v9qA:undetectable | 1dscC-2v9qA:10.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w7q | OUTER-MEMBRANELIPOPROTEIN CARRIERPROTEIN (Pseudomonasaeruginosa) |
PF03548(LolA) | 3 | THR A 108THR A 106PRO A 109 | None | 0.82A | 1dscC-2w7qA:undetectable | 1dscC-2w7qA:4.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xmr | PROTEIN NDRG2 (Homo sapiens) |
PF03096(Ndr) | 3 | THR A 267THR A 269PRO A 266 | None | 0.80A | 1dscC-2xmrA:undetectable | 1dscC-2xmrA:7.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xut | PROTON/PEPTIDESYMPORTER FAMILYPROTEIN (Shewanellaoneidensis) |
PF00854(PTR2) | 3 | THR A 470THR A 468PRO A 467 | None | 0.83A | 1dscC-2xutA:undetectable | 1dscC-2xutA:4.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6j | PUTATIVE HALOACIDDEHALOGENASE-LIKEHYDROLASE (Bacteroidesfragilis) |
PF13419(HAD_2) | 3 | THR A 94THR A 96PRO A 93 | None | 0.82A | 1dscC-3d6jA:undetectable | 1dscC-3d6jA:4.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fmt | PROTEIN SEQA (Escherichiacoli) |
PF03925(SeqA)PF17206(SeqA_N) | 3 | THR A 135THR A 149PRO A 137 | None | 0.82A | 1dscC-3fmtA:undetectable | 1dscC-3fmtA:5.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g05 | TRNA URIDINE5-CARBOXYMETHYLAMINOMETHYL MODIFICATIONENZYME MNMG (Escherichiacoli) |
PF01134(GIDA)PF13932(GIDA_assoc) | 3 | THR A 201THR A 314PRO A 202 | None | 0.81A | 1dscC-3g05A:undetectable | 1dscC-3g05A:3.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1l | CYTOCHROME B (Gallus gallus) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 3 | THR C 175THR C 177PRO C 174 | None | 0.84A | 1dscC-3h1lC:undetectable | 1dscC-3h1lC:2.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1q | ETHANOLAMINEUTILIZATION PROTEINEUTJ (Carboxydothermushydrogenoformans) |
PF14450(FtsA) | 3 | THR A 147THR A 166PRO A 165 | None | 0.80A | 1dscC-3h1qA:undetectable | 1dscC-3h1qA:4.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5l | PUTATIVEBRANCHED-CHAIN AMINOACID ABC TRANSPORTER (Ruegeriapomeroyi) |
PF13458(Peripla_BP_6) | 3 | THR A 395THR A 397PRO A 394 | None | 0.71A | 1dscC-3h5lA:undetectable | 1dscC-3h5lA:4.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hoa | THERMOSTABLECARBOXYPEPTIDASE 1 (Thermusthermophilus) |
PF02074(Peptidase_M32) | 3 | THR A 429THR A 431PRO A 428 | None | 0.84A | 1dscC-3hoaA:undetectable | 1dscC-3hoaA:2.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ikm | DNA POLYMERASESUBUNIT GAMMA-1 (Homo sapiens) |
PF00476(DNA_pol_A) | 3 | THR A 636THR A 638PRO A 635 | None | 0.70A | 1dscC-3ikmA:undetectable | 1dscC-3ikmA:0.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iq2 | SORTING NEXIN-7 (Homo sapiens) |
PF00787(PX) | 3 | THR A 133THR A 135PRO A 132 | None | 0.82A | 1dscC-3iq2A:undetectable | 1dscC-3iq2A:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k70 | EXODEOXYRIBONUCLEASEV ALPHA CHAIN (Escherichiacoli) |
PF13538(UvrD_C_2)PF13604(AAA_30) | 3 | THR D 205THR D 239PRO D 204 | None | 0.79A | 1dscC-3k70D:undetectable | 1dscC-3k70D:2.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9d | ALDEHYDEDEHYDROGENASE (Listeriamonocytogenes) |
PF00171(Aldedh) | 3 | THR A 122THR A 124PRO A 121 | CL A 465 (-4.1A)None CL A 465 (-4.1A) | 0.64A | 1dscC-3k9dA:undetectable | 1dscC-3k9dA:3.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxm | ASPARTATECARBAMOYLTRANSFERASE (Yersinia pestis) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 137THR A 139PRO A 136 | None | 0.65A | 1dscC-3lxmA:undetectable | 1dscC-3lxmA:3.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my7 | ALCOHOLDEHYDROGENASE/ACETALDEHYDE DEHYDROGENASE (Vibrioparahaemolyticus) |
PF00171(Aldedh) | 3 | THR A 117THR A 119PRO A 116 | CL A 453 ( 4.4A)None CL A 453 ( 4.6A) | 0.71A | 1dscC-3my7A:undetectable | 1dscC-3my7A:3.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nvq | SEMAPHORIN-7A (Homo sapiens) |
PF01403(Sema)PF01437(PSI)PF13895(Ig_2) | 3 | THR A 377THR A 375PRO A 374 | None | 0.84A | 1dscC-3nvqA:undetectable | 1dscC-3nvqA:4.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rd8 | FUMARATE HYDRATASECLASS II (Mycolicibacteriumsmegmatis) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 3 | THR A 143THR A 145PRO A 142 | None | 0.83A | 1dscC-3rd8A:undetectable | 1dscC-3rd8A:2.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3thz | DNA MISMATCH REPAIRPROTEIN MSH2 (Homo sapiens) |
PF00488(MutS_V)PF01624(MutS_I)PF05188(MutS_II)PF05190(MutS_IV)PF05192(MutS_III) | 3 | THR A 33THR A 31PRO A 30 | None | 0.84A | 1dscC-3thzA:undetectable | 1dscC-3thzA:1.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vnp | HYPOTHETICALCONSERVED PROTEIN (Geobacilluskaustophilus) |
PF00132(Hexapep) | 3 | THR A 9THR A 25PRO A 4 | None | 0.83A | 1dscC-3vnpA:undetectable | 1dscC-3vnpA:9.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wuf | ENDO-1,4-BETA-XYLANASE A (Streptomycessp.) |
PF00331(Glyco_hydro_10) | 3 | THR A 80THR A 58PRO A 81 | None | 0.81A | 1dscC-3wufA:undetectable | 1dscC-3wufA:4.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zsu | TLL2057 PROTEIN (Thermosynechococcuselongatus) |
no annotation | 3 | THR A 103THR A 105PRO A 102 | None | 0.80A | 1dscC-3zsuA:undetectable | 1dscC-3zsuA:7.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a1r | LIP (Serratiamarcescens) |
PF12790(T6SS-SciN) | 3 | THR A 143THR A 145PRO A 142 | None | 0.82A | 1dscC-4a1rA:undetectable | 1dscC-4a1rA:5.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4apb | FUMARATE HYDRATASECLASS II (Mycobacteriumtuberculosis) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 3 | THR A 145THR A 147PRO A 144 | None | 0.82A | 1dscC-4apbA:undetectable | 1dscC-4apbA:4.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4av6 | K(+)-STIMULATEDPYROPHOSPHATE-ENERGIZED SODIUM PUMP (Thermotogamaritima) |
PF03030(H_PPase) | 3 | THR A 421THR A 423PRO A 420 | None | 0.72A | 1dscC-4av6A:undetectable | 1dscC-4av6A:2.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4brz | HALOALKANEDEHALOGENASE (Rhodobacteraceae) |
PF00561(Abhydrolase_1) | 3 | THR A 203THR A 205PRO A 202 | None | 0.76A | 1dscC-4brzA:undetectable | 1dscC-4brzA:4.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4byf | UNCONVENTIONALMYOSIN-IC (Homo sapiens) |
PF00063(Myosin_head)PF00612(IQ) | 3 | THR A 650THR A 647PRO A 649 | None | 0.70A | 1dscC-4byfA:undetectable | 1dscC-4byfA:1.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eog | PUTATIVEUNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF09455(Cas_DxTHG) | 3 | THR A 174THR A 176PRO A 173 | None | 0.79A | 1dscC-4eogA:undetectable | 1dscC-4eogA:5.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ez5 | CYCLIN-DEPENDENTKINASE 6 (Homo sapiens) |
PF00069(Pkinase) | 3 | THR A 121THR A 119PRO A 118 | None | 0.82A | 1dscC-4ez5A:undetectable | 1dscC-4ez5A:6.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fnq | ALPHA-GALACTOSIDASEAGAB (Geobacillusstearothermophilus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 3 | THR A 187THR A 268PRO A 186 | None | 0.77A | 1dscC-4fnqA:undetectable | 1dscC-4fnqA:1.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwi | HEAT SHOCK COGNATE71 KDA PROTEIN (Homo sapiens) |
PF00012(HSP70) | 3 | THR A 64THR A 66PRO A 63 | None | 0.72A | 1dscC-4hwiA:undetectable | 1dscC-4hwiA:5.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j4j | DNA DC->DU-EDITINGENZYME APOBEC-3F (Homo sapiens) |
PF08210(APOBEC_N) | 3 | THR A -19THR A -17PRO A -20 | None | 0.80A | 1dscC-4j4jA:undetectable | 1dscC-4j4jA:8.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j4s | NUCLEOCAPSID PROTEIN (SFTSphlebovirus) |
PF05733(Tenui_N) | 3 | THR A 113THR A 115PRO A 112 | None | 0.75A | 1dscC-4j4sA:undetectable | 1dscC-4j4sA:4.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kjd | INTESTINAL-TYPEALKALINE PHOSPHATASE1 (Rattusnorvegicus) |
PF00245(Alk_phosphatase) | 3 | THR A 48THR A 50PRO A 47 | None | 0.83A | 1dscC-4kjdA:undetectable | 1dscC-4kjdA:2.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l2j | OSMOTIN: ANTIFUNGALLATICIFER PROTEIN (Calotropisprocera) |
PF00314(Thaumatin) | 3 | THR A 187THR A 189PRO A 186 | None | 0.78A | 1dscC-4l2jA:undetectable | 1dscC-4l2jA:3.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m88 | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Verminephrobactereiseniae) |
PF13458(Peripla_BP_6) | 3 | THR A 150THR A 152PRO A 149 | GOL A 402 (-3.6A)NoneNone | 0.84A | 1dscC-4m88A:undetectable | 1dscC-4m88A:4.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mif | PYRANOSE 2-OXIDASE (Phanerochaetechrysosporium) |
PF05199(GMC_oxred_C) | 3 | THR A 598THR A 600PRO A 597 | FDA A 801 (-3.4A)NoneFDA A 801 (-4.1A) | 0.80A | 1dscC-4mifA:undetectable | 1dscC-4mifA:1.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ov4 | 2-ISOPROPYLMALATESYNTHASE (Leptospirabiflexa) |
PF00682(HMGL-like) | 3 | THR A 178THR A 208PRO A 176 | KIV A 402 (-2.8A)NoneKIV A 402 (-4.2A) | 0.77A | 1dscC-4ov4A:undetectable | 1dscC-4ov4A:2.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u16 | MUSCARINICACETYLCHOLINERECEPTORM3,LYSOZYME,MUSCARINIC ACETYLCHOLINERECEPTOR M3 (Rattusnorvegicus;Escherichiavirus T4) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | THR A 229THR A 231PRO A 228 | None | 0.72A | 1dscC-4u16A:undetectable | 1dscC-4u16A:4.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u4h | TEGUMENT PROTEINUL21 (Humanalphaherpesvirus1) |
PF03252(Herpes_UL21) | 3 | THR A 164THR A 124PRO A 165 | None | 0.83A | 1dscC-4u4hA:undetectable | 1dscC-4u4hA:7.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uu9 | MEDI7814 (Homo sapiens) |
PF07686(V-set) | 3 | THR B 94THR B 95PRO B 93 | None | 0.80A | 1dscC-4uu9B:undetectable | 1dscC-4uu9B:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzb | NITROGENASEMOLYBDENUM-IRONPROTEIN ALPHA CHAIN (Azotobactervinelandii) |
PF00148(Oxidored_nitro) | 3 | THR A 303THR A 305PRO A 302 | None | 0.69A | 1dscC-4wzbA:undetectable | 1dscC-4wzbA:4.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xv0 | BETA-XYLANASE (Trichodermareesei) |
PF00331(Glyco_hydro_10) | 3 | THR A 89THR A 67PRO A 90 | None | 0.80A | 1dscC-4xv0A:undetectable | 1dscC-4xv0A:7.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvh | CARBOHYDRATEESTERASE FAMILY 2(CE2) (Chaetomium) |
PF13472(Lipase_GDSL_2) | 3 | THR A 288THR A 285PRO A 287 | None | 0.56A | 1dscC-4xvhA:undetectable | 1dscC-4xvhA:3.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aff | SYMPORTIN 1 (Chaetomiumthermophilum) |
no annotation | 3 | THR A 280THR A 282PRO A 279 | None | 0.84A | 1dscC-5affA:undetectable | 1dscC-5affA:1.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwy | PLASMEPSIN-2 (Plasmodiumfalciparum) |
PF00026(Asp) | 3 | THR A 114THR A 116PRO A 113 | None | 0.62A | 1dscC-5bwyA:undetectable | 1dscC-5bwyA:2.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dis | MALTOSE-BINDINGPERIPLASMICPROTEIN,NUCLEAR PORECOMPLEX PROTEINNUP214 (Escherichiacoli;Homo sapiens) |
PF13416(SBP_bac_8) | 3 | THR D1944THR D1946PRO D1943 | None | 0.70A | 1dscC-5disD:undetectable | 1dscC-5disD:2.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eod | COAGULATION FACTORXI (Homo sapiens) |
PF00024(PAN_1)PF00089(Trypsin) | 3 | THR A 393THR A 390PRO A 392 | None | 0.74A | 1dscC-5eodA:undetectable | 1dscC-5eodA:1.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fpn | HEAT SHOCK-RELATED70 KDA PROTEIN 2 (Homo sapiens) |
PF00012(HSP70) | 3 | THR A 64THR A 66PRO A 63 | None | 0.74A | 1dscC-5fpnA:undetectable | 1dscC-5fpnA:4.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5glg | FUMARATE REDUCTASE 2 (Saccharomycescerevisiae) |
PF00890(FAD_binding_2) | 3 | THR A 431THR A 283PRO A 432 | None | 0.80A | 1dscC-5glgA:undetectable | 1dscC-5glgA:2.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gwe | CYTOCHROME P450 (Corynebacteriumglutamicum) |
PF00067(p450) | 3 | THR A 197THR A 199PRO A 196 | None | 0.83A | 1dscC-5gweA:undetectable | 1dscC-5gweA:1.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ia8 | UBIQUITIN-LIKEMODIFIER-ACTIVATINGENZYME5,UBIQUITIN-FOLDMODIFIER 1 (Homo sapiens) |
PF03671(Ufm1) | 3 | THR A 27THR A 62PRO A 28 | None | 0.79A | 1dscC-5ia8A:undetectable | 1dscC-5ia8A:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j78 | ACETALDEHYDEDEHYDROGENASE(ACETYLATING) (Parageobacillusthermoglucosidasius) |
PF00171(Aldedh) | 3 | THR A 144THR A 146PRO A 143 | ACT A1005 (-3.3A)NoneACT A1005 (-3.9A) | 0.62A | 1dscC-5j78A:undetectable | 1dscC-5j78A:2.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfm | ALDEHYDEDEHYDROGENASE (Rhodopseudomonaspalustris) |
PF00171(Aldedh) | 3 | THR A 201THR A 203PRO A 200 | None | 0.65A | 1dscC-5jfmA:undetectable | 1dscC-5jfmA:3.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lj3 | PRE-MRNA-SPLICINGFACTOR BUD31 (Saccharomycescerevisiae) |
PF01125(G10) | 3 | THR L 22THR L 24PRO L 21 | None | 0.69A | 1dscC-5lj3L:undetectable | 1dscC-5lj3L:7.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5of4 | GENERALTRANSCRIPTION FACTORIIH SUBUNIT4,P52,GENERALTRANSCRIPTION FACTORIIH SUBUNIT 4 (Homo sapiens) |
no annotation | 3 | THR D 386THR D 388PRO D 385 | None | 0.79A | 1dscC-5of4D:undetectable | 1dscC-5of4D:10.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0a | GLUCANASE (Trichodermaharzianum) |
no annotation | 3 | THR A 7THR A 5PRO A 8 | THR A 7 ( 0.8A)THR A 5 ( 0.8A)PRO A 8 ( 1.1A) | 0.74A | 1dscC-5w0aA:undetectable | 1dscC-5w0aA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1u | CARBOXYLIC ESTERHYDROLASE (Culexquinquefasciatus) |
PF00135(COesterase) | 3 | THR A 505THR A 502PRO A 504 | None | 0.73A | 1dscC-5w1uA:undetectable | 1dscC-5w1uA:2.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w81 | CYSTIC FIBROSISTRANSMEMBRANECONDUCTANCEREGULATOR (Danio rerio) |
PF00005(ABC_tran)PF00664(ABC_membrane)PF14396(CFTR_R) | 3 | THR A 538THR A 500PRO A 539 | None | 0.83A | 1dscC-5w81A:undetectable | 1dscC-5w81A:1.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfa | NAD-REDUCINGHYDROGENASE (Hydrogenophilusthermoluteolus) |
PF01257(2Fe-2S_thioredx)PF01512(Complex1_51K)PF10589(NADH_4Fe-4S) | 3 | THR A 212THR A 210PRO A 209 | None | 0.81A | 1dscC-5xfaA:undetectable | 1dscC-5xfaA:2.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xjn | CYTOCHROME P450 (Corynebacteriumglutamicum) |
PF00067(p450) | 3 | THR A 170THR A 172PRO A 169 | None | 0.76A | 1dscC-5xjnA:undetectable | 1dscC-5xjnA:2.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yid | PLASMEPSIN II (Plasmodiumfalciparum) |
no annotation | 3 | THR A 116THR A 118PRO A 115 | K95 A 401 ( 4.9A)NoneCPS A 402 ( 4.9A) | 0.84A | 1dscC-5yidA:undetectable | 1dscC-5yidA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z9y | THIAZOLE SYNTHASE (Mycobacteriumtuberculosis) |
no annotation | 3 | THR A 67THR A 42PRO A 68 | None | 0.80A | 1dscC-5z9yA:undetectable | 1dscC-5z9yA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ayi | HTH-TYPETRANSCRIPTIONALREGULATOR UIDR (Escherichiacoli) |
no annotation | 3 | THR A 14THR A 12PRO A 11 | None | 0.83A | 1dscC-6ayiA:undetectable | 1dscC-6ayiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq1 | PHOSPHATIDYLINOSITOL4-KINASE III ALPHA(PI4KA) (Homo sapiens) |
no annotation | 3 | THR A1074THR A1076PRO A1073 | None | 0.80A | 1dscC-6bq1A:undetectable | 1dscC-6bq1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dll | P-HYDROXYBENZOATEHYDROXYLASE (Pseudomonasputida) |
no annotation | 3 | THR A 192THR A 217PRO A 193 | None | 0.73A | 1dscC-6dllA:undetectable | 1dscC-6dllA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fuz | KINESIN LIGHT CHAIN1,KINESIN LIGHTCHAIN1,C-JUN-AMINO-TERMINALKINASE-INTERACTINGPROTEIN 1 (Homo sapiens;Mus musculus) |
no annotation | 3 | THR A 462THR A 464PRO A 461 | None | 0.80A | 1dscC-6fuzA:undetectable | 1dscC-6fuzA:undetectable |