SIMILAR PATTERNS OF AMINO ACIDS FOR 1DSC_C_DVAC2_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aun | PR-5D (Nicotianatabacum) |
PF00314(Thaumatin) | 3 | THR A 190PRO A 187THR A 188 | None | 0.80A | 1dscC-1aunA:undetectable | 1dscC-1aunA:4.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhg | BETA-GLUCURONIDASE (Homo sapiens) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 3 | THR A 117PRO A 224THR A 223 | None | 0.88A | 1dscC-1bhgA:undetectable | 1dscC-1bhgA:4.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cld | CD2-LAC9 (Kluyveromyceslactis) |
PF00172(Zn_clus) | 3 | THR A 108PRO A 110THR A 111 | None | 0.94A | 1dscC-1cldA:undetectable | 1dscC-1cldA:28.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eg1 | ENDOGLUCANASE I (Trichodermareesei) |
PF00840(Glyco_hydro_7) | 3 | THR A 5PRO A 8THR A 7 | None | 0.67A | 1dscC-1eg1A:undetectable | 1dscC-1eg1A:4.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gom | ENDO-1,4-BETA-XYLANASE (Thermoascusaurantiacus) |
PF00331(Glyco_hydro_10) | 3 | THR A 22PRO A 45THR A 44 | None | 0.94A | 1dscC-1gomA:undetectable | 1dscC-1gomA:3.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3e | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 3 | THR A 84PRO A 72THR A 70 | None | 0.89A | 1dscC-1j3eA:undetectable | 1dscC-1j3eA:9.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jcn | INOSINEMONOPHOSPHATEDEHYDROGENASE I (Homo sapiens) |
PF00478(IMPDH)PF00571(CBS) | 3 | THR A 52PRO A 64THR A 63 | None | 0.94A | 1dscC-1jcnA:undetectable | 1dscC-1jcnA:2.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jio | CYTOCHROME P450107A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 3 | THR A 97PRO A 95THR A 99 | None | 0.95A | 1dscC-1jioA:undetectable | 1dscC-1jioA:7.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jr1 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (Cricetulusgriseus) |
PF00478(IMPDH)PF00571(CBS) | 3 | THR A 52PRO A 64THR A 63 | None | 0.96A | 1dscC-1jr1A:undetectable | 1dscC-1jr1A:2.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kj0 | SERINE PROTEASEINHIBITOR I (Schistocercagregaria) |
PF05375(Pacifastin_I) | 3 | THR A 5PRO A 21THR A 20 | None | 0.91A | 1dscC-1kj0A:undetectable | 1dscC-1kj0A:38.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kj0 | SERINE PROTEASEINHIBITOR I (Schistocercagregaria) |
PF05375(Pacifastin_I) | 3 | THR A 20PRO A 6THR A 5 | None | 0.95A | 1dscC-1kj0A:undetectable | 1dscC-1kj0A:38.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1krm | ADENOSINE DEAMINASE (Bos taurus) |
PF00962(A_deaminase) | 3 | THR A 266PRO A 56THR A 54 | None | 0.90A | 1dscC-1krmA:undetectable | 1dscC-1krmA:4.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kwg | BETA-GALACTOSIDASE (Thermusthermophilus) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 3 | THR A 73PRO A 76THR A 75 | None | 0.96A | 1dscC-1kwgA:undetectable | 1dscC-1kwgA:2.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrr | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 3 | THR A 149PRO A 137THR A 135 | None | 0.91A | 1dscC-1lrrA:undetectable | 1dscC-1lrrA:6.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m64 | FLAVOCYTOCHROME C3 (Shewanellafrigidimarina) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 3 | THR A 367PRO A 501THR A 500 | None | 0.88A | 1dscC-1m64A:undetectable | 1dscC-1m64A:2.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m64 | FLAVOCYTOCHROME C3 (Shewanellafrigidimarina) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 3 | THR A 500PRO A 366THR A 367 | None | 0.96A | 1dscC-1m64A:undetectable | 1dscC-1m64A:2.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ml4 | ASPARTATETRANSCARBAMOYLASE (Pyrococcusabyssi) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 139PRO A 136THR A 137 | None | 0.97A | 1dscC-1ml4A:undetectable | 1dscC-1ml4A:3.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nwa | PEPTIDE METHIONINESULFOXIDE REDUCTASEMSRA (Mycobacteriumtuberculosis) |
PF01625(PMSR) | 3 | THR A 63PRO A 60THR A 61 | None | 0.87A | 1dscC-1nwaA:undetectable | 1dscC-1nwaA:7.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ux6 | THROMBOSPONDIN-1 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 3 | THR A1032PRO A1034THR A1035 | None | 0.71A | 1dscC-1ux6A:undetectable | 1dscC-1ux6A:4.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w5e | FTSZ (Methanocaldococcusjannaschii) |
PF00091(Tubulin)PF12327(FtsZ_C) | 3 | THR A 135PRO A 101THR A 137 | GTP A 500 (-3.6A)NoneNone | 0.96A | 1dscC-1w5eA:undetectable | 1dscC-1w5eA:3.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w5f | CELL DIVISIONPROTEIN FTSZ (Thermotogamaritima) |
PF00091(Tubulin)PF12327(FtsZ_C) | 3 | THR A 119PRO A 85THR A 121 | G2P A 500 (-3.6A)NoneNone | 0.97A | 1dscC-1w5fA:undetectable | 1dscC-1w5fA:3.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xru | 4-DEOXY-L-THREO-5-HEXOSULOSE-URONATEKETOL-ISOMERASE (Escherichiacoli) |
PF04962(KduI) | 3 | THR A 120PRO A 123THR A 122 | None | 0.95A | 1dscC-1xruA:undetectable | 1dscC-1xruA:4.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yuz | NIGERYTHRIN (Desulfovibriovulgaris) |
PF02915(Rubrerythrin) | 3 | THR A 200PRO A 175THR A 198 | None | 0.95A | 1dscC-1yuzA:undetectable | 1dscC-1yuzA:6.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlr | COAGULATION FACTORXI (Homo sapiens) |
PF00089(Trypsin) | 3 | THR A 36PRO A 37THR A 37 | None | 0.58A | 1dscC-1zlrA:undetectable | 1dscC-1zlrA:4.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zn6 | PHAGE-RELATEDCONSERVEDHYPOTHETICAL PROTEIN (Bordetellabronchiseptica) |
PF02586(SRAP) | 3 | THR A 201PRO A 197THR A 199 | None | 0.89A | 1dscC-1zn6A:undetectable | 1dscC-1zn6A:5.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zwt | MAJOR STRUCTURALSUBUNIT OFBUNDLE-FORMING PILUS (Escherichiacoli) |
PF05307(Bundlin) | 3 | THR A 99PRO A 137THR A 136 | None | 0.92A | 1dscC-1zwtA:undetectable | 1dscC-1zwtA:14.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cl2 | PUTATIVELAMINARINASE (Phanerochaetechrysosporium) |
no annotation | 3 | THR A 252PRO A 100THR A 98 | None | 0.92A | 1dscC-2cl2A:undetectable | 1dscC-2cl2A:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ksk | SUGARCANE DEFENSIN 5 (Saccharumofficinarum) |
PF00304(Gamma-thionin) | 3 | THR A 2PRO A 5THR A 4 | None | 0.91A | 1dscC-2kskA:undetectable | 1dscC-2kskA:8.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ljp | RIBONUCLEASE PPROTEIN COMPONENT (Escherichiacoli) |
PF00825(Ribonuclease_P) | 3 | THR A 34PRO A 31THR A 30 | None | 0.90A | 1dscC-2ljpA:undetectable | 1dscC-2ljpA:8.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r6r | CELL DIVISIONPROTEIN FTSZ (Aquifexaeolicus) |
PF00091(Tubulin)PF12327(FtsZ_C) | 3 | THR 1 105PRO 1 71THR 1 107 | GDP 1 339 (-4.3A)NoneNone | 0.93A | 1dscC-2r6r1:undetectable | 1dscC-2r6r1:4.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vxy | CELL DIVISIONPROTEIN FTSZ (Bacillussubtilis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 3 | THR A 109PRO A 75THR A 111 | CIT A 401 (-3.6A)NoneNone | 0.95A | 1dscC-2vxyA:undetectable | 1dscC-2vxyA:5.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w7q | OUTER-MEMBRANELIPOPROTEIN CARRIERPROTEIN (Pseudomonasaeruginosa) |
PF03548(LolA) | 3 | THR A 106PRO A 109THR A 108 | None | 0.87A | 1dscC-2w7qA:undetectable | 1dscC-2w7qA:4.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xut | PROTON/PEPTIDESYMPORTER FAMILYPROTEIN (Shewanellaoneidensis) |
PF00854(PTR2) | 3 | THR A 468PRO A 467THR A 470 | None | 0.97A | 1dscC-2xutA:undetectable | 1dscC-2xutA:4.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z5x | AMINE OXIDASE[FLAVIN-CONTAINING]A (Homo sapiens) |
PF01593(Amino_oxidase) | 3 | THR A 278PRO A 274THR A 276 | NoneFAD A 600 ( 4.9A)None | 0.97A | 1dscC-2z5xA:undetectable | 1dscC-2z5xA:1.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aup | BASIC 7S GLOBULIN (Glycine max) |
PF14541(TAXi_C)PF14543(TAXi_N) | 3 | THR A 266PRO A 269THR A 268 | None | 0.84A | 1dscC-3aupA:undetectable | 1dscC-3aupA:4.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cbu | PROBABLE GST-RELATEDPROTEIN (Cupriaviduspinatubonensis) |
PF13410(GST_C_2)PF13417(GST_N_3) | 3 | THR A 40PRO A 43THR A 42 | None | 0.95A | 1dscC-3cbuA:undetectable | 1dscC-3cbuA:6.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dao | PUTATIVE PHOSPHATE ([Eubacterium]rectale) |
PF08282(Hydrolase_3) | 3 | THR A 69PRO A 82THR A 80 | None | 0.96A | 1dscC-3daoA:undetectable | 1dscC-3daoA:9.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fg6 | ADSEVERIN (Homo sapiens) |
PF00626(Gelsolin) | 3 | THR A 704PRO A 700THR A 702 | None | 0.85A | 1dscC-3fg6A:undetectable | 1dscC-3fg6A:3.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g05 | TRNA URIDINE5-CARBOXYMETHYLAMINOMETHYL MODIFICATIONENZYME MNMG (Escherichiacoli) |
PF01134(GIDA)PF13932(GIDA_assoc) | 3 | THR A 314PRO A 202THR A 201 | None | 0.95A | 1dscC-3g05A:undetectable | 1dscC-3g05A:3.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gle | PILIN (Streptococcuspyogenes) |
PF12892(FctA) | 3 | THR A 84PRO A 48THR A 50 | THR A 84 ( 0.8A)PRO A 48 ( 1.1A)THR A 50 ( 0.8A) | 0.86A | 1dscC-3gleA:undetectable | 1dscC-3gleA:9.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ij3 | CYTOSOLAMINOPEPTIDASE (Coxiellaburnetii) |
PF00883(Peptidase_M17) | 3 | THR A 305PRO A 290THR A 307 | None | 0.96A | 1dscC-3ij3A:undetectable | 1dscC-3ij3A:2.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ikm | DNA POLYMERASESUBUNIT GAMMA-1 (Homo sapiens) |
PF00476(DNA_pol_A) | 3 | THR A 638PRO A 635THR A 636 | None | 0.78A | 1dscC-3ikmA:undetectable | 1dscC-3ikmA:0.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j81 | US2 (Kluyveromyceslactis) |
PF00318(Ribosomal_S2) | 3 | THR A 124PRO A 126THR A 147 | None | 0.92A | 1dscC-3j81A:undetectable | 1dscC-3j81A:4.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k70 | EXODEOXYRIBONUCLEASEV ALPHA CHAIN (Escherichiacoli) |
PF13538(UvrD_C_2)PF13604(AAA_30) | 3 | THR D 239PRO D 204THR D 205 | None | 0.91A | 1dscC-3k70D:undetectable | 1dscC-3k70D:2.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9d | ALDEHYDEDEHYDROGENASE (Listeriamonocytogenes) |
PF00171(Aldedh) | 3 | THR A 124PRO A 121THR A 122 | None CL A 465 (-4.1A) CL A 465 (-4.1A) | 0.85A | 1dscC-3k9dA:undetectable | 1dscC-3k9dA:3.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3krv | HYDROLASE (Geobacillusstearothermophilus) |
PF04199(Cyclase) | 3 | THR A 48PRO A 195THR A 46 | None | 0.91A | 1dscC-3krvA:undetectable | 1dscC-3krvA:5.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxm | ASPARTATECARBAMOYLTRANSFERASE (Yersinia pestis) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 139PRO A 136THR A 137 | None | 0.94A | 1dscC-3lxmA:undetectable | 1dscC-3lxmA:3.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m07 | PUTATIVE ALPHAAMYLASE (Salmonellaenterica) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 3 | THR A 122PRO A 125THR A 124 | None | 0.90A | 1dscC-3m07A:undetectable | 1dscC-3m07A:1.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mml | ALLOPHANATEHYDROLASE SUBUNIT 1 (Mycolicibacteriumsmegmatis) |
PF02682(CT_C_D) | 3 | THR B 117PRO B 120THR B 119 | None | 0.93A | 1dscC-3mmlB:undetectable | 1dscC-3mmlB:6.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my7 | ALCOHOLDEHYDROGENASE/ACETALDEHYDE DEHYDROGENASE (Vibrioparahaemolyticus) |
PF00171(Aldedh) | 3 | THR A 119PRO A 116THR A 117 | None CL A 453 ( 4.6A) CL A 453 ( 4.4A) | 0.85A | 1dscC-3my7A:undetectable | 1dscC-3my7A:3.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qef | BETA-XYLOSIDASE/ALPHA-L-ARABINFURANOSIDASE, GLY43N (Cellvibriojaponicus) |
PF04616(Glyco_hydro_43) | 3 | THR A 158PRO A 161THR A 160 | None | 0.94A | 1dscC-3qefA:undetectable | 1dscC-3qefA:3.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sc2 | SERINECARBOXYPEPTIDASE II(CPDW-II) (Triticumaestivum) |
PF00450(Peptidase_S10) | 3 | THR B 346PRO B 342THR B 344 | None | 0.94A | 1dscC-3sc2B:undetectable | 1dscC-3sc2B:7.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sz4 | EXONUCLEASE (Laribacterhongkongensis) |
PF09588(YqaJ) | 3 | THR A 118PRO A 116THR A 120 | None | 0.88A | 1dscC-3sz4A:undetectable | 1dscC-3sz4A:7.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3v | E1 ENVELOPEGLYCOPROTEIN (Rubella virus) |
PF05748(Rubella_E1) | 3 | THR A 137PRO A 134THR A 135 | None | 0.91A | 1dscC-4b3vA:undetectable | 1dscC-4b3vA:2.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bil | DNA MATURASE B (Escherichiavirus T7) |
no annotation | 3 | THR A 261PRO A 263THR A 259 | None | 0.78A | 1dscC-4bilA:undetectable | 1dscC-4bilA:2.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btp | P1 (Pseudomonasphage phi8) |
no annotation | 3 | THR A 297PRO A 299THR A 295 | None | 0.90A | 1dscC-4btpA:undetectable | 1dscC-4btpA:3.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4byf | UNCONVENTIONALMYOSIN-IC (Homo sapiens) |
PF00063(Myosin_head)PF00612(IQ) | 3 | THR A 647PRO A 649THR A 650 | None | 0.56A | 1dscC-4byfA:undetectable | 1dscC-4byfA:1.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cni | INTERLEUKIN-6 (Homo sapiens) |
PF00489(IL6) | 3 | THR C 137PRO C 139THR C 138 | None | 0.95A | 1dscC-4cniC:undetectable | 1dscC-4cniC:6.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4euf | PUTATIVE REDUCTASECA_C0462 (Clostridiumacetobutylicum) |
PF07055(Eno-Rase_FAD_bd)PF12241(Enoyl_reductase)PF12242(Eno-Rase_NADH_b) | 3 | THR A 284PRO A 286THR A 168 | None | 0.86A | 1dscC-4eufA:undetectable | 1dscC-4eufA:1.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f1h | TYROSYL-DNAPHOSPHODIESTERASE 2 (Danio rerio) |
PF03372(Exo_endo_phos) | 3 | THR A 211PRO A 209THR A 210 | None | 0.94A | 1dscC-4f1hA:undetectable | 1dscC-4f1hA:29.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdw | LEUCINE RICHHYPOTHETICAL PROTEIN (Bacteroidesovatus) |
PF07523(Big_3)PF13306(LRR_5) | 3 | THR A 217PRO A 192THR A 194 | None | 0.95A | 1dscC-4fdwA:undetectable | 1dscC-4fdwA:4.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fnq | ALPHA-GALACTOSIDASEAGAB (Geobacillusstearothermophilus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 3 | THR A 268PRO A 186THR A 187 | None | 0.95A | 1dscC-4fnqA:undetectable | 1dscC-4fnqA:1.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g4i | 4-O-METHYL-GLUCURONOYL METHYLESTERASE (Thermothelomycesthermophila) |
no annotation | 3 | THR A 210PRO A 234THR A 232 | None | 0.91A | 1dscC-4g4iA:undetectable | 1dscC-4g4iA:3.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwi | HEAT SHOCK COGNATE71 KDA PROTEIN (Homo sapiens) |
PF00012(HSP70) | 3 | THR A 66PRO A 63THR A 64 | None | 0.94A | 1dscC-4hwiA:undetectable | 1dscC-4hwiA:5.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzp | BIFUNCTIONALMETHYLMALONYL-COA:ACPACYLTRANSFERASE/DECARBOXYLASE (Streptomycesatroolivaceus) |
no annotation | 3 | THR A 280PRO A 283THR A 282 | None | 0.94A | 1dscC-4hzpA:undetectable | 1dscC-4hzpA:4.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jru | THAUMATIN-LIKEPROTEIN (Vitis vinifera) |
PF00314(Thaumatin) | 3 | THR A 100PRO A 102THR A 86 | None | 0.92A | 1dscC-4jruA:undetectable | 1dscC-4jruA:7.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ov4 | 2-ISOPROPYLMALATESYNTHASE (Leptospirabiflexa) |
PF00682(HMGL-like) | 3 | THR A 208PRO A 176THR A 178 | NoneKIV A 402 (-4.2A)KIV A 402 (-2.8A) | 0.92A | 1dscC-4ov4A:undetectable | 1dscC-4ov4A:2.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovj | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Alicyclobacillusacidocaldarius) |
PF13416(SBP_bac_8) | 3 | THR A 259PRO A 255THR A 257 | None | 0.87A | 1dscC-4ovjA:undetectable | 1dscC-4ovjA:4.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qor | CATALASE (Bacilluspumilus) |
PF00199(Catalase)PF06628(Catalase-rel) | 3 | THR A 169PRO A 172THR A 171 | None | 0.90A | 1dscC-4qorA:undetectable | 1dscC-4qorA:2.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf3 | NADPH DEPENDENTR-SPECIFIC ALCOHOLDEHYDROGENASE (Lactobacilluskefiri) |
PF13561(adh_short_C2) | 3 | THR A 210PRO A 213THR A 212 | None | 0.94A | 1dscC-4rf3A:undetectable | 1dscC-4rf3A:9.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u39 | CELL DIVISIONPROTEIN FTSZ (Bacillussubtilis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 3 | THR A 109PRO A 75THR A 111 | PO4 A 401 (-4.1A)NoneNone | 0.86A | 1dscC-4u39A:undetectable | 1dscC-4u39A:4.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u4h | TEGUMENT PROTEINUL21 (Humanalphaherpesvirus1) |
PF03252(Herpes_UL21) | 3 | THR A 124PRO A 165THR A 164 | None | 0.94A | 1dscC-4u4hA:undetectable | 1dscC-4u4hA:7.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uu9 | MEDI7814 (Homo sapiens) |
PF07686(V-set) | 3 | THR B 95PRO B 93THR B 94 | None | 0.81A | 1dscC-4uu9B:undetectable | 1dscC-4uu9B:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xky | DIHYDRODIPICOLINATESYNTHASE (Bacteroidesthetaiotaomicron) |
PF00701(DHDPS) | 3 | THR A 142PRO A 139THR A 140 | None | 0.93A | 1dscC-4xkyA:undetectable | 1dscC-4xkyA:3.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xv0 | BETA-XYLANASE (Trichodermareesei) |
PF00331(Glyco_hydro_10) | 3 | THR A 67PRO A 90THR A 89 | None | 0.94A | 1dscC-4xv0A:undetectable | 1dscC-4xv0A:7.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvh | CARBOHYDRATEESTERASE FAMILY 2(CE2) (Chaetomium) |
PF13472(Lipase_GDSL_2) | 3 | THR A 285PRO A 287THR A 288 | None | 0.58A | 1dscC-4xvhA:undetectable | 1dscC-4xvhA:3.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a35 | GLYCINE CLEAVAGESYSTEM H PROTEIN (Streptococcuspyogenes) |
PF01597(GCV_H) | 3 | THR A 77PRO A 80THR A 79 | None | 0.94A | 1dscC-5a35A:undetectable | 1dscC-5a35A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ah5 | LEUCINE--TRNA LIGASE (Agrobacteriumtumefaciens) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1)PF13603(tRNA-synt_1_2) | 3 | THR A 152PRO A 187THR A 186 | None | 0.88A | 1dscC-5ah5A:undetectable | 1dscC-5ah5A:5.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwy | PLASMEPSIN-2 (Plasmodiumfalciparum) |
PF00026(Asp) | 3 | THR A 116PRO A 113THR A 114 | None | 0.73A | 1dscC-5bwyA:undetectable | 1dscC-5bwyA:2.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2z | EXFOLIATIVE TOXIN D2 (Staphylococcusaureus) |
PF00089(Trypsin) | 3 | THR A 192PRO A 187THR A 190 | None | 0.94A | 1dscC-5c2zA:undetectable | 1dscC-5c2zA:5.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dis | MALTOSE-BINDINGPERIPLASMICPROTEIN,NUCLEAR PORECOMPLEX PROTEINNUP214 (Escherichiacoli;Homo sapiens) |
PF13416(SBP_bac_8) | 3 | THR D1946PRO D1943THR D1944 | None | 0.70A | 1dscC-5disD:undetectable | 1dscC-5disD:2.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dyn | PUTATIVE PEPTIDASE (Bacteroidesfragilis) |
PF03415(Peptidase_C11) | 3 | THR B 282PRO B 278THR B 388 | None | 0.91A | 1dscC-5dynB:undetectable | 1dscC-5dynB:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7o | DMSO REDUCTASEFAMILY TYPE IIENZYME, IRON-SULFURSUBUNIT (Azospira oryzae) |
PF13247(Fer4_11) | 3 | THR B 141PRO B 254THR B 252 | NoneNoneSF4 B 403 ( 4.9A) | 0.96A | 1dscC-5e7oB:undetectable | 1dscC-5e7oB:4.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eod | COAGULATION FACTORXI (Homo sapiens) |
PF00024(PAN_1)PF00089(Trypsin) | 3 | THR A 390PRO A 392THR A 393 | None | 0.77A | 1dscC-5eodA:undetectable | 1dscC-5eodA:1.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5glg | FUMARATE REDUCTASE 2 (Saccharomycescerevisiae) |
PF00890(FAD_binding_2) | 3 | THR A 283PRO A 432THR A 431 | None | 0.87A | 1dscC-5glgA:undetectable | 1dscC-5glgA:2.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gne | LEUCINEAMINOPEPTIDASE (Legionellapneumophila) |
PF04389(Peptidase_M28) | 3 | THR A 321PRO A 327THR A 326 | None | 0.95A | 1dscC-5gneA:undetectable | 1dscC-5gneA:4.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ia8 | UBIQUITIN-LIKEMODIFIER-ACTIVATINGENZYME5,UBIQUITIN-FOLDMODIFIER 1 (Homo sapiens) |
PF03671(Ufm1) | 3 | THR A 62PRO A 28THR A 27 | None | 0.94A | 1dscC-5ia8A:undetectable | 1dscC-5ia8A:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6o | PUTATIVE POLYKETIDESYNTHASE (Brevibacillusbrevis) |
PF14765(PS-DH) | 3 | THR A1993PRO A2054THR A2053 | None | 0.92A | 1dscC-5j6oA:undetectable | 1dscC-5j6oA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j78 | ACETALDEHYDEDEHYDROGENASE(ACETYLATING) (Parageobacillusthermoglucosidasius) |
PF00171(Aldedh) | 3 | THR A 146PRO A 143THR A 144 | NoneACT A1005 (-3.9A)ACT A1005 (-3.3A) | 0.79A | 1dscC-5j78A:undetectable | 1dscC-5j78A:2.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfm | ALDEHYDEDEHYDROGENASE (Rhodopseudomonaspalustris) |
PF00171(Aldedh) | 3 | THR A 203PRO A 200THR A 201 | None | 0.78A | 1dscC-5jfmA:undetectable | 1dscC-5jfmA:3.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k0y | EUKARYOTICTRANSLATIONINITIATION FACTOR 2SUBUNIT 1 (Oryctolaguscuniculus) |
PF00575(S1)PF07541(EIF_2_alpha) | 3 | THR P 220PRO P 224THR P 222 | None | 0.94A | 1dscC-5k0yP:undetectable | 1dscC-5k0yP:4.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nmp | ISATIN HYDROLASE (Ralstoniasolanacearum) |
no annotation | 3 | THR A 77PRO A 255THR A 75 | None | 0.86A | 1dscC-5nmpA:undetectable | 1dscC-5nmpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnb | ISATIN HYDROLASE A (Labrenziaaggregata) |
no annotation | 3 | THR A 72PRO A 248THR A 70 | None | 0.88A | 1dscC-5nnbA:undetectable | 1dscC-5nnbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5of4 | GENERALTRANSCRIPTION FACTORIIH SUBUNIT4,P52,GENERALTRANSCRIPTION FACTORIIH SUBUNIT 4 (Homo sapiens) |
no annotation | 3 | THR D 388PRO D 385THR D 386 | None | 0.83A | 1dscC-5of4D:undetectable | 1dscC-5of4D:10.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0a | GLUCANASE (Trichodermaharzianum) |
no annotation | 3 | THR A 5PRO A 8THR A 7 | THR A 5 ( 0.8A)PRO A 8 ( 1.1A)THR A 7 ( 0.8A) | 0.73A | 1dscC-5w0aA:undetectable | 1dscC-5w0aA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1u | CARBOXYLIC ESTERHYDROLASE (Culexquinquefasciatus) |
PF00135(COesterase) | 3 | THR A 502PRO A 504THR A 505 | None | 0.58A | 1dscC-5w1uA:undetectable | 1dscC-5w1uA:2.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xb0 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Pseudomonassyringae groupgenomosp. 3) |
PF00254(FKBP_C) | 3 | THR A 133PRO A 135THR A 184 | None | 0.95A | 1dscC-5xb0A:undetectable | 1dscC-5xb0A:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cxh | PARTICULATE METHANEMONOOXYGENASE, ASUBUNIT (Methylomicrobiumalcaliphilum) |
no annotation | 3 | THR B 191PRO B 194THR B 193 | None | 0.93A | 1dscC-6cxhB:undetectable | 1dscC-6cxhB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dll | P-HYDROXYBENZOATEHYDROXYLASE (Pseudomonasputida) |
no annotation | 3 | THR A 217PRO A 193THR A 192 | None | 0.84A | 1dscC-6dllA:undetectable | 1dscC-6dllA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fb3 | TENEURIN-2 (Gallus gallus) |
no annotation | 3 | THR A1828PRO A1820THR A1826 | None | 0.84A | 1dscC-6fb3A:undetectable | 1dscC-6fb3A:undetectable |