SIMILAR PATTERNS OF AMINO ACIDS FOR 1DSC_C_DVAC2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aun PR-5D

(Nicotiana
tabacum)
PF00314
(Thaumatin)
3 THR A 190
PRO A 187
THR A 188
None
0.80A 1dscC-1aunA:
undetectable
1dscC-1aunA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 THR A 117
PRO A 224
THR A 223
None
0.88A 1dscC-1bhgA:
undetectable
1dscC-1bhgA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cld CD2-LAC9

(Kluyveromyces
lactis)
PF00172
(Zn_clus)
3 THR A 108
PRO A 110
THR A 111
None
0.94A 1dscC-1cldA:
undetectable
1dscC-1cldA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei)
PF00840
(Glyco_hydro_7)
3 THR A   5
PRO A   8
THR A   7
None
0.67A 1dscC-1eg1A:
undetectable
1dscC-1eg1A:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gom ENDO-1,4-BETA-XYLANA
SE


(Thermoascus
aurantiacus)
PF00331
(Glyco_hydro_10)
3 THR A  22
PRO A  45
THR A  44
None
0.94A 1dscC-1gomA:
undetectable
1dscC-1gomA:
3.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3e SEQA PROTEIN

(Escherichia
coli)
PF03925
(SeqA)
3 THR A  84
PRO A  72
THR A  70
None
0.89A 1dscC-1j3eA:
undetectable
1dscC-1j3eA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I


(Homo sapiens)
PF00478
(IMPDH)
PF00571
(CBS)
3 THR A  52
PRO A  64
THR A  63
None
0.94A 1dscC-1jcnA:
undetectable
1dscC-1jcnA:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
3 THR A  97
PRO A  95
THR A  99
None
0.95A 1dscC-1jioA:
undetectable
1dscC-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2


(Cricetulus
griseus)
PF00478
(IMPDH)
PF00571
(CBS)
3 THR A  52
PRO A  64
THR A  63
None
0.96A 1dscC-1jr1A:
undetectable
1dscC-1jr1A:
2.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kj0 SERINE PROTEASE
INHIBITOR I


(Schistocerca
gregaria)
PF05375
(Pacifastin_I)
3 THR A   5
PRO A  21
THR A  20
None
0.91A 1dscC-1kj0A:
undetectable
1dscC-1kj0A:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kj0 SERINE PROTEASE
INHIBITOR I


(Schistocerca
gregaria)
PF05375
(Pacifastin_I)
3 THR A  20
PRO A   6
THR A   5
None
0.95A 1dscC-1kj0A:
undetectable
1dscC-1kj0A:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus)
PF00962
(A_deaminase)
3 THR A 266
PRO A  56
THR A  54
None
0.90A 1dscC-1krmA:
undetectable
1dscC-1krmA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
3 THR A  73
PRO A  76
THR A  75
None
0.96A 1dscC-1kwgA:
undetectable
1dscC-1kwgA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrr SEQA PROTEIN

(Escherichia
coli)
PF03925
(SeqA)
3 THR A 149
PRO A 137
THR A 135
None
0.91A 1dscC-1lrrA:
undetectable
1dscC-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina)
PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2)
3 THR A 367
PRO A 501
THR A 500
None
0.88A 1dscC-1m64A:
undetectable
1dscC-1m64A:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina)
PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2)
3 THR A 500
PRO A 366
THR A 367
None
0.96A 1dscC-1m64A:
undetectable
1dscC-1m64A:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE


(Pyrococcus
abyssi)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 139
PRO A 136
THR A 137
None
0.97A 1dscC-1ml4A:
undetectable
1dscC-1ml4A:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA


(Mycobacterium
tuberculosis)
PF01625
(PMSR)
3 THR A  63
PRO A  60
THR A  61
None
0.87A 1dscC-1nwaA:
undetectable
1dscC-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
3 THR A1032
PRO A1034
THR A1035
None
0.71A 1dscC-1ux6A:
undetectable
1dscC-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
3 THR A 135
PRO A 101
THR A 137
GTP  A 500 (-3.6A)
None
None
0.96A 1dscC-1w5eA:
undetectable
1dscC-1w5eA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5f CELL DIVISION
PROTEIN FTSZ


(Thermotoga
maritima)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
3 THR A 119
PRO A  85
THR A 121
G2P  A 500 (-3.6A)
None
None
0.97A 1dscC-1w5fA:
undetectable
1dscC-1w5fA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xru 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE


(Escherichia
coli)
PF04962
(KduI)
3 THR A 120
PRO A 123
THR A 122
None
0.95A 1dscC-1xruA:
undetectable
1dscC-1xruA:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yuz NIGERYTHRIN

(Desulfovibrio
vulgaris)
PF02915
(Rubrerythrin)
3 THR A 200
PRO A 175
THR A 198
None
0.95A 1dscC-1yuzA:
undetectable
1dscC-1yuzA:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI


(Homo sapiens)
PF00089
(Trypsin)
3 THR A  36
PRO A  37
THR A  37
None
0.58A 1dscC-1zlrA:
undetectable
1dscC-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zn6 PHAGE-RELATED
CONSERVED
HYPOTHETICAL PROTEIN


(Bordetella
bronchiseptica)
PF02586
(SRAP)
3 THR A 201
PRO A 197
THR A 199
None
0.89A 1dscC-1zn6A:
undetectable
1dscC-1zn6A:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwt MAJOR STRUCTURAL
SUBUNIT OF
BUNDLE-FORMING PILUS


(Escherichia
coli)
PF05307
(Bundlin)
3 THR A  99
PRO A 137
THR A 136
None
0.92A 1dscC-1zwtA:
undetectable
1dscC-1zwtA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE


(Phanerochaete
chrysosporium)
no annotation 3 THR A 252
PRO A 100
THR A  98
None
0.92A 1dscC-2cl2A:
undetectable
1dscC-2cl2A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ksk SUGARCANE DEFENSIN 5

(Saccharum
officinarum)
PF00304
(Gamma-thionin)
3 THR A   2
PRO A   5
THR A   4
None
0.91A 1dscC-2kskA:
undetectable
1dscC-2kskA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljp RIBONUCLEASE P
PROTEIN COMPONENT


(Escherichia
coli)
PF00825
(Ribonuclease_P)
3 THR A  34
PRO A  31
THR A  30
None
0.90A 1dscC-2ljpA:
undetectable
1dscC-2ljpA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ


(Aquifex
aeolicus)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
3 THR 1 105
PRO 1  71
THR 1 107
GDP  1 339 (-4.3A)
None
None
0.93A 1dscC-2r6r1:
undetectable
1dscC-2r6r1:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ


(Bacillus
subtilis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
3 THR A 109
PRO A  75
THR A 111
CIT  A 401 (-3.6A)
None
None
0.95A 1dscC-2vxyA:
undetectable
1dscC-2vxyA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7q OUTER-MEMBRANE
LIPOPROTEIN CARRIER
PROTEIN


(Pseudomonas
aeruginosa)
PF03548
(LolA)
3 THR A 106
PRO A 109
THR A 108
None
0.87A 1dscC-2w7qA:
undetectable
1dscC-2w7qA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN


(Shewanella
oneidensis)
PF00854
(PTR2)
3 THR A 468
PRO A 467
THR A 470
None
0.97A 1dscC-2xutA:
undetectable
1dscC-2xutA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A


(Homo sapiens)
PF01593
(Amino_oxidase)
3 THR A 278
PRO A 274
THR A 276
None
FAD  A 600 ( 4.9A)
None
0.97A 1dscC-2z5xA:
undetectable
1dscC-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max)
PF14541
(TAXi_C)
PF14543
(TAXi_N)
3 THR A 266
PRO A 269
THR A 268
None
0.84A 1dscC-3aupA:
undetectable
1dscC-3aupA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbu PROBABLE GST-RELATED
PROTEIN


(Cupriavidus
pinatubonensis)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
3 THR A  40
PRO A  43
THR A  42
None
0.95A 1dscC-3cbuA:
undetectable
1dscC-3cbuA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dao PUTATIVE PHOSPHATE

([Eubacterium]
rectale)
PF08282
(Hydrolase_3)
3 THR A  69
PRO A  82
THR A  80
None
0.96A 1dscC-3daoA:
undetectable
1dscC-3daoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens)
PF00626
(Gelsolin)
3 THR A 704
PRO A 700
THR A 702
None
0.85A 1dscC-3fg6A:
undetectable
1dscC-3fg6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG


(Escherichia
coli)
PF01134
(GIDA)
PF13932
(GIDA_assoc)
3 THR A 314
PRO A 202
THR A 201
None
0.95A 1dscC-3g05A:
undetectable
1dscC-3g05A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gle PILIN

(Streptococcus
pyogenes)
PF12892
(FctA)
3 THR A  84
PRO A  48
THR A  50
THR  A  84 ( 0.8A)
PRO  A  48 ( 1.1A)
THR  A  50 ( 0.8A)
0.86A 1dscC-3gleA:
undetectable
1dscC-3gleA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE


(Coxiella
burnetii)
PF00883
(Peptidase_M17)
3 THR A 305
PRO A 290
THR A 307
None
0.96A 1dscC-3ij3A:
undetectable
1dscC-3ij3A:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00476
(DNA_pol_A)
3 THR A 638
PRO A 635
THR A 636
None
0.78A 1dscC-3ikmA:
undetectable
1dscC-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j81 US2

(Kluyveromyces
lactis)
PF00318
(Ribosomal_S2)
3 THR A 124
PRO A 126
THR A 147
None
0.92A 1dscC-3j81A:
undetectable
1dscC-3j81A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN


(Escherichia
coli)
PF13538
(UvrD_C_2)
PF13604
(AAA_30)
3 THR D 239
PRO D 204
THR D 205
None
0.91A 1dscC-3k70D:
undetectable
1dscC-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE


(Listeria
monocytogenes)
PF00171
(Aldedh)
3 THR A 124
PRO A 121
THR A 122
None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
0.85A 1dscC-3k9dA:
undetectable
1dscC-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus)
PF04199
(Cyclase)
3 THR A  48
PRO A 195
THR A  46
None
0.91A 1dscC-3krvA:
undetectable
1dscC-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE


(Yersinia pestis)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 139
PRO A 136
THR A 137
None
0.94A 1dscC-3lxmA:
undetectable
1dscC-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE


(Salmonella
enterica)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
3 THR A 122
PRO A 125
THR A 124
None
0.90A 1dscC-3m07A:
undetectable
1dscC-3m07A:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 1


(Mycolicibacterium
smegmatis)
PF02682
(CT_C_D)
3 THR B 117
PRO B 120
THR B 119
None
0.93A 1dscC-3mmlB:
undetectable
1dscC-3mmlB:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE


(Vibrio
parahaemolyticus)
PF00171
(Aldedh)
3 THR A 119
PRO A 116
THR A 117
None
CL  A 453 ( 4.6A)
CL  A 453 ( 4.4A)
0.85A 1dscC-3my7A:
undetectable
1dscC-3my7A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qef BETA-XYLOSIDASE/ALPH
A-L-ARABINFURANOSIDA
SE, GLY43N


(Cellvibrio
japonicus)
PF04616
(Glyco_hydro_43)
3 THR A 158
PRO A 161
THR A 160
None
0.94A 1dscC-3qefA:
undetectable
1dscC-3qefA:
3.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)


(Triticum
aestivum)
PF00450
(Peptidase_S10)
3 THR B 346
PRO B 342
THR B 344
None
0.94A 1dscC-3sc2B:
undetectable
1dscC-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz4 EXONUCLEASE

(Laribacter
hongkongensis)
PF09588
(YqaJ)
3 THR A 118
PRO A 116
THR A 120
None
0.88A 1dscC-3sz4A:
undetectable
1dscC-3sz4A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3v E1 ENVELOPE
GLYCOPROTEIN


(Rubella virus)
PF05748
(Rubella_E1)
3 THR A 137
PRO A 134
THR A 135
None
0.91A 1dscC-4b3vA:
undetectable
1dscC-4b3vA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bil DNA MATURASE B

(Escherichia
virus T7)
no annotation 3 THR A 261
PRO A 263
THR A 259
None
0.78A 1dscC-4bilA:
undetectable
1dscC-4bilA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8)
no annotation 3 THR A 297
PRO A 299
THR A 295
None
0.90A 1dscC-4btpA:
undetectable
1dscC-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC


(Homo sapiens)
PF00063
(Myosin_head)
PF00612
(IQ)
3 THR A 647
PRO A 649
THR A 650
None
0.56A 1dscC-4byfA:
undetectable
1dscC-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cni INTERLEUKIN-6

(Homo sapiens)
PF00489
(IL6)
3 THR C 137
PRO C 139
THR C 138
None
0.95A 1dscC-4cniC:
undetectable
1dscC-4cniC:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euf PUTATIVE REDUCTASE
CA_C0462


(Clostridium
acetobutylicum)
PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b)
3 THR A 284
PRO A 286
THR A 168
None
0.86A 1dscC-4eufA:
undetectable
1dscC-4eufA:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2


(Danio rerio)
PF03372
(Exo_endo_phos)
3 THR A 211
PRO A 209
THR A 210
None
0.94A 1dscC-4f1hA:
undetectable
1dscC-4f1hA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN


(Bacteroides
ovatus)
PF07523
(Big_3)
PF13306
(LRR_5)
3 THR A 217
PRO A 192
THR A 194
None
0.95A 1dscC-4fdwA:
undetectable
1dscC-4fdwA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB


(Geobacillus
stearothermophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
3 THR A 268
PRO A 186
THR A 187
None
0.95A 1dscC-4fnqA:
undetectable
1dscC-4fnqA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE


(Thermothelomyces
thermophila)
no annotation 3 THR A 210
PRO A 234
THR A 232
None
0.91A 1dscC-4g4iA:
undetectable
1dscC-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN


(Homo sapiens)
PF00012
(HSP70)
3 THR A  66
PRO A  63
THR A  64
None
0.94A 1dscC-4hwiA:
undetectable
1dscC-4hwiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE


(Streptomyces
atroolivaceus)
no annotation 3 THR A 280
PRO A 283
THR A 282
None
0.94A 1dscC-4hzpA:
undetectable
1dscC-4hzpA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jru THAUMATIN-LIKE
PROTEIN


(Vitis vinifera)
PF00314
(Thaumatin)
3 THR A 100
PRO A 102
THR A  86
None
0.92A 1dscC-4jruA:
undetectable
1dscC-4jruA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE


(Leptospira
biflexa)
PF00682
(HMGL-like)
3 THR A 208
PRO A 176
THR A 178
None
KIV  A 402 (-4.2A)
KIV  A 402 (-2.8A)
0.92A 1dscC-4ov4A:
undetectable
1dscC-4ov4A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Alicyclobacillus
acidocaldarius)
PF13416
(SBP_bac_8)
3 THR A 259
PRO A 255
THR A 257
None
0.87A 1dscC-4ovjA:
undetectable
1dscC-4ovjA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 THR A 169
PRO A 172
THR A 171
None
0.90A 1dscC-4qorA:
undetectable
1dscC-4qorA:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE


(Lactobacillus
kefiri)
PF13561
(adh_short_C2)
3 THR A 210
PRO A 213
THR A 212
None
0.94A 1dscC-4rf3A:
undetectable
1dscC-4rf3A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ


(Bacillus
subtilis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
3 THR A 109
PRO A  75
THR A 111
PO4  A 401 (-4.1A)
None
None
0.86A 1dscC-4u39A:
undetectable
1dscC-4u39A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4h TEGUMENT PROTEIN
UL21


(Human
alphaherpesvirus
1)
PF03252
(Herpes_UL21)
3 THR A 124
PRO A 165
THR A 164
None
0.94A 1dscC-4u4hA:
undetectable
1dscC-4u4hA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu9 MEDI7814

(Homo sapiens)
PF07686
(V-set)
3 THR B  95
PRO B  93
THR B  94
None
0.81A 1dscC-4uu9B:
undetectable
1dscC-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xky DIHYDRODIPICOLINATE
SYNTHASE


(Bacteroides
thetaiotaomicron)
PF00701
(DHDPS)
3 THR A 142
PRO A 139
THR A 140
None
0.93A 1dscC-4xkyA:
undetectable
1dscC-4xkyA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xv0 BETA-XYLANASE

(Trichoderma
reesei)
PF00331
(Glyco_hydro_10)
3 THR A  67
PRO A  90
THR A  89
None
0.94A 1dscC-4xv0A:
undetectable
1dscC-4xv0A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)


(Chaetomium)
PF13472
(Lipase_GDSL_2)
3 THR A 285
PRO A 287
THR A 288
None
0.58A 1dscC-4xvhA:
undetectable
1dscC-4xvhA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN


(Streptococcus
pyogenes)
PF01597
(GCV_H)
3 THR A  77
PRO A  80
THR A  79
None
0.94A 1dscC-5a35A:
undetectable
1dscC-5a35A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens)
PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
3 THR A 152
PRO A 187
THR A 186
None
0.88A 1dscC-5ah5A:
undetectable
1dscC-5ah5A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum)
PF00026
(Asp)
3 THR A 116
PRO A 113
THR A 114
None
0.73A 1dscC-5bwyA:
undetectable
1dscC-5bwyA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2z EXFOLIATIVE TOXIN D2

(Staphylococcus
aureus)
PF00089
(Trypsin)
3 THR A 192
PRO A 187
THR A 190
None
0.94A 1dscC-5c2zA:
undetectable
1dscC-5c2zA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214


(Escherichia
coli;
Homo sapiens)
PF13416
(SBP_bac_8)
3 THR D1946
PRO D1943
THR D1944
None
0.70A 1dscC-5disD:
undetectable
1dscC-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis)
PF03415
(Peptidase_C11)
3 THR B 282
PRO B 278
THR B 388
None
0.91A 1dscC-5dynB:
undetectable
1dscC-5dynB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7o DMSO REDUCTASE
FAMILY TYPE II
ENZYME, IRON-SULFUR
SUBUNIT


(Azospira oryzae)
PF13247
(Fer4_11)
3 THR B 141
PRO B 254
THR B 252
None
None
SF4  B 403 ( 4.9A)
0.96A 1dscC-5e7oB:
undetectable
1dscC-5e7oB:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI


(Homo sapiens)
PF00024
(PAN_1)
PF00089
(Trypsin)
3 THR A 390
PRO A 392
THR A 393
None
0.77A 1dscC-5eodA:
undetectable
1dscC-5eodA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae)
PF00890
(FAD_binding_2)
3 THR A 283
PRO A 432
THR A 431
None
0.87A 1dscC-5glgA:
undetectable
1dscC-5glgA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE


(Legionella
pneumophila)
PF04389
(Peptidase_M28)
3 THR A 321
PRO A 327
THR A 326
None
0.95A 1dscC-5gneA:
undetectable
1dscC-5gneA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ia8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME
5,UBIQUITIN-FOLD
MODIFIER 1


(Homo sapiens)
PF03671
(Ufm1)
3 THR A  62
PRO A  28
THR A  27
None
0.94A 1dscC-5ia8A:
undetectable
1dscC-5ia8A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6o PUTATIVE POLYKETIDE
SYNTHASE


(Brevibacillus
brevis)
PF14765
(PS-DH)
3 THR A1993
PRO A2054
THR A2053
None
0.92A 1dscC-5j6oA:
undetectable
1dscC-5j6oA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)


(Parageobacillus
thermoglucosidasius)
PF00171
(Aldedh)
3 THR A 146
PRO A 143
THR A 144
None
ACT  A1005 (-3.9A)
ACT  A1005 (-3.3A)
0.79A 1dscC-5j78A:
undetectable
1dscC-5j78A:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE


(Rhodopseudomonas
palustris)
PF00171
(Aldedh)
3 THR A 203
PRO A 200
THR A 201
None
0.78A 1dscC-5jfmA:
undetectable
1dscC-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1


(Oryctolagus
cuniculus)
PF00575
(S1)
PF07541
(EIF_2_alpha)
3 THR P 220
PRO P 224
THR P 222
None
0.94A 1dscC-5k0yP:
undetectable
1dscC-5k0yP:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmp ISATIN HYDROLASE

(Ralstonia
solanacearum)
no annotation 3 THR A  77
PRO A 255
THR A  75
None
0.86A 1dscC-5nmpA:
undetectable
1dscC-5nmpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnb ISATIN HYDROLASE A

(Labrenzia
aggregata)
no annotation 3 THR A  72
PRO A 248
THR A  70
None
0.88A 1dscC-5nnbA:
undetectable
1dscC-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4


(Homo sapiens)
no annotation 3 THR D 388
PRO D 385
THR D 386
None
0.83A 1dscC-5of4D:
undetectable
1dscC-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum)
no annotation 3 THR A   5
PRO A   8
THR A   7
THR  A   5 ( 0.8A)
PRO  A   8 ( 1.1A)
THR  A   7 ( 0.8A)
0.73A 1dscC-5w0aA:
undetectable
1dscC-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE


(Culex
quinquefasciatus)
PF00135
(COesterase)
3 THR A 502
PRO A 504
THR A 505
None
0.58A 1dscC-5w1uA:
undetectable
1dscC-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Pseudomonas
syringae group
genomosp. 3)
PF00254
(FKBP_C)
3 THR A 133
PRO A 135
THR A 184
None
0.95A 1dscC-5xb0A:
undetectable
1dscC-5xb0A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT


(Methylomicrobium
alcaliphilum)
no annotation 3 THR B 191
PRO B 194
THR B 193
None
0.93A 1dscC-6cxhB:
undetectable
1dscC-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE


(Pseudomonas
putida)
no annotation 3 THR A 217
PRO A 193
THR A 192
None
0.84A 1dscC-6dllA:
undetectable
1dscC-6dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus)
no annotation 3 THR A1828
PRO A1820
THR A1826
None
0.84A 1dscC-6fb3A:
undetectable
1dscC-6fb3A:
undetectable