SIMILAR PATTERNS OF AMINO ACIDS FOR 1DMA_B_NCAB700_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtp DIPHTHERIA TOXIN

(Corynephage
beta) 		PF02763
(Diphtheria_C) 		5 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.54A 1dmaB-1dtpA:
9.2		 1dmaB-1dtpA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus gallus) 		PF00644
(PARP)
PF02877
(PARP_reg) 		6 HIS A 862
GLY A 863
TYR A 896
ALA A 898
TYR A 907
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
 0.44A 1dmaB-1efyA:
5.6		 1dmaB-1efyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f99 R-PHYCOCYANIN

(Polysiphonia
urceolata) 		PF00502
(Phycobilisome) 		4 HIS A 140
GLY A 141
ALA A  43
GLU A  39
 None
 0.82A 1dmaB-1f99A:
undetectable		 1dmaB-1f99A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1faw HEMOGLOBIN (ALPHA
SUBUNIT)

(Anser anser) 		PF00042
(Globin) 		4 HIS A  50
GLY A  51
ALA A  26
GLU A  23
 None
 0.93A 1dmaB-1fawA:
undetectable		 1dmaB-1fawA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htn TETRANECTIN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 GLY A  90
TYR A  97
ALA A  95
GLU A  98
 None
 0.89A 1dmaB-1htnA:
undetectable		 1dmaB-1htnA:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		6 HIS A 440
GLY A 441
TYR A 470
ALA A 472
TYR A 481
GLU A 553
 None
 0.57A 1dmaB-1ikpA:
28.3		 1dmaB-1ikpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		4 GLY B 509
ALA B 465
TYR B 521
GLU B 468
 None
 0.98A 1dmaB-1k5sB:
undetectable		 1dmaB-1k5sB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1j HEMOGLOBIN ALPHA
CHAIN

(Homo sapiens) 		PF00042
(Globin) 		4 HIS A 192
GLY A 193
ALA A 168
GLU A 165
 None
 1.02A 1dmaB-1o1jA:
undetectable		 1dmaB-1o1jA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovw ENDOGLUCANASE I

(Fusarium
oxysporum) 		PF00840
(Glyco_hydro_7) 		4 GLY A  36
TYR A 167
ALA A  33
GLU A   8
 None
 1.01A 1dmaB-1ovwA:
undetectable		 1dmaB-1ovwA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p27 RNA-BINDING PROTEIN
8A

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLY B 115
TYR B 112
ALA B  84
GLU B  83
 None
 1.03A 1dmaB-1p27B:
undetectable		 1dmaB-1p27B:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qot CHITIN BINDING
LECTIN, UEA-II

(Ulex europaeus) 		PF00139
(Lectin_legB) 		4 HIS A 227
GLY A 217
ALA A  89
GLU A 126
 None
None
None
MN  A 301 (-2.5A)
 0.70A 1dmaB-1qotA:
undetectable		 1dmaB-1qotA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		4 HIS A  17
GLY A  38
ALA A  88
TYR A  39
 None
None
NAD  A 360 (-3.6A)
None
 1.00A 1dmaB-1rkxA:
undetectable		 1dmaB-1rkxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 GLY A 113
TYR A  72
ALA A 135
GLU A 139
 None
ADP  A 400 (-3.6A)
None
MG  A 600 ( 4.9A)
 0.77A 1dmaB-1s4eA:
undetectable		 1dmaB-1s4eA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp3 CYTOCHROME C,
PUTATIVE

(Shewanella
oneidensis) 		PF11783
(Cytochrome_cB)
PF13435
(Cytochrome_C554) 		4 HIS A  78
TYR A  81
ALA A 115
GLU A 117
 None
 0.88A 1dmaB-1sp3A:
undetectable		 1dmaB-1sp3A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		4 GLY A 441
TYR A 454
ALA A 444
GLU A 383
 None
 0.89A 1dmaB-1venA:
undetectable		 1dmaB-1venA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whw HYPOTHETICAL PROTEIN
RIKEN CDNA
1200009A02

(Mus musculus) 		PF00076
(RRM_1) 		4 HIS A  91
GLY A  62
ALA A  95
GLU A  98
 None
 0.86A 1dmaB-1whwA:
undetectable		 1dmaB-1whwA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wve 4-CRESOL
DEHYDROGENASE
[HYDROXYLATING]
FLAVOPROTEIN SUBUNIT

(Pseudomonas
putida) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 HIS A 291
GLY A 382
ALA A 287
GLU A 286
 None
 0.94A 1dmaB-1wveA:
undetectable		 1dmaB-1wveA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi9 PUTATIVE
TRANSAMINASE

(Pyrococcus
furiosus) 		PF00155
(Aminotran_1_2) 		4 HIS A 369
GLY A 368
TYR A 365
GLU A 364
 None
 0.95A 1dmaB-1xi9A:
undetectable		 1dmaB-1xi9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 219
TYR A 187
ALA A 183
GLU A 184
 None
 0.98A 1dmaB-1ykwA:
undetectable		 1dmaB-1ykwA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		4 GLY A 612
TYR A 398
TYR A 613
GLU A 434
 None
UGA  A1101 (-4.5A)
None
UGA  A1101 (-4.0A)
 0.79A 1dmaB-1z7eA:
undetectable		 1dmaB-1z7eA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9v CONSERVED
HYPOTHETICAL PROTEIN
MTH0776

(Methanothermobacter
thermautotrophicus) 		PF08979
(DUF1894) 		4 GLY A  80
ALA A  82
TYR A  79
GLU A  27
 None
 1.00A 1dmaB-1z9vA:
undetectable		 1dmaB-1z9vA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		4 GLY A 100
TYR A  64
ALA A  95
GLU A  93
 None
 0.82A 1dmaB-1zbsA:
undetectable		 1dmaB-1zbsA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2brt LEUCOANTHOCYANIDIN
DIOXYGENASE

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 GLY A 126
TYR A 216
TYR A 125
GLU A   8
 None
 0.97A 1dmaB-2brtA:
undetectable		 1dmaB-2brtA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dej PROBABLE
GALACTOKINASE

(Pyrococcus
horikoshii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 GLY A 111
TYR A  70
ALA A 133
GLU A 137
 None
APW  A 402 (-3.8A)
None
APW  A 402 ( 4.8A)
 0.86A 1dmaB-2dejA:
undetectable		 1dmaB-2dejA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY A 226
TYR A 185
ALA A 221
GLU A 188
 DT8  A 700 (-3.5A)
None
None
None
 0.94A 1dmaB-2ei8A:
undetectable		 1dmaB-2ei8A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		4 GLY A 453
TYR A 459
ALA A 463
GLU A 462
 None
 1.04A 1dmaB-2euhA:
undetectable		 1dmaB-2euhA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		4 GLY A  83
TYR A  90
ALA A  88
GLU A  91
 None
 0.92A 1dmaB-2gfiA:
undetectable		 1dmaB-2gfiA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		4 HIS A 266
GLY A  12
TYR A 290
ALA A 270
 None
 0.99A 1dmaB-2gt1A:
undetectable		 1dmaB-2gt1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF08327
(AHSA1) 		4 GLY A  99
TYR A  64
ALA A  62
GLU A  51
 None
 0.95A 1dmaB-2ldkA:
undetectable		 1dmaB-2ldkA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 GLY A 507
ALA A 558
TYR A 506
GLU A 559
 None
 0.83A 1dmaB-2oajA:
undetectable		 1dmaB-2oajA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		4 HIS A 217
GLY A   9
ALA A 154
GLU A 158
 None
 1.02A 1dmaB-2oy0A:
undetectable		 1dmaB-2oy0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqf POLY [ADP-RIBOSE]
POLYMERASE 12

(Homo sapiens) 		PF00644
(PARP) 		5 HIS A 564
GLY A 565
TYR A 596
ALA A 598
TYR A 607
 GAB  A 701 ( 3.7A)
GAB  A 701 (-3.6A)
GAB  A 701 (-4.5A)
GAB  A 701 (-3.3A)
GAB  A 701 (-3.3A)
 0.34A 1dmaB-2pqfA:
5.0		 1dmaB-2pqfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvf PUTATIVE
NICKEL-RESPONSIVE
REGULATOR

(Helicobacter
pylori) 		PF01402
(RHH_1)
PF08753
(NikR_C) 		4 GLY A 129
TYR A  72
ALA A 136
GLU A 109
 None
None
None
FMT  A1147 ( 4.5A)
 0.84A 1dmaB-2wvfA:
undetectable		 1dmaB-2wvfA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b78 EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly) 		6 HIS B 440
GLY B 441
TYR B 470
ALA B 472
TYR B 481
GLU B 553
 NAD  B 700 (-3.9A)
NAD  B 700 (-3.9A)
NAD  B 700 (-3.9A)
NAD  B 700 ( 4.2A)
NAD  B 700 (-3.4A)
NAD  B 700 (-3.5A)
 0.51A 1dmaB-3b78B:
29.3		 1dmaB-3b78B:
99.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A 534
TYR A 503
ALA A 500
TYR A 506
 None
 0.95A 1dmaB-3bc9A:
undetectable		 1dmaB-3bc9A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdk D-MANNONATE
DEHYDRATASE

(Streptococcus
suis) 		PF03786
(UxuA) 		4 GLY A  29
ALA A  51
TYR A  28
GLU A  84
 None
None
None
DNO  A 387 ( 4.8A)
 1.01A 1dmaB-3bdkA:
undetectable		 1dmaB-3bdkA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c49 POLY(ADP-RIBOSE)
POLYMERASE 3

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg) 		6 HIS A 384
GLY A 385
TYR A 414
ALA A 416
TYR A 425
GLU A 514
 KU8  A 601 (-4.0A)
KU8  A 601 (-3.5A)
KU8  A 601 (-4.1A)
KU8  A 601 ( 4.0A)
KU8  A 601 (-3.5A)
KU8  A 601 (-3.9A)
 0.53A 1dmaB-3c49A:
5.8		 1dmaB-3c49A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq2 PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF07228
(SpoIIE) 		4 GLY A 271
TYR A 196
ALA A 205
TYR A 207
 None
 1.04A 1dmaB-3eq2A:
undetectable		 1dmaB-3eq2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es2 PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF07228
(SpoIIE) 		4 GLY A 271
TYR A 196
ALA A 205
TYR A 207
 None
 0.93A 1dmaB-3es2A:
undetectable		 1dmaB-3es2A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdj HEMOGLOBIN SUBUNIT
ALPHA

(Camelus
dromedarius) 		PF00042
(Globin) 		4 HIS A  50
GLY A  51
ALA A  26
GLU A  23
 None
 0.96A 1dmaB-3gdjA:
undetectable		 1dmaB-3gdjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkv POLY [ADP-RIBOSE]
POLYMERASE 10

(Homo sapiens) 		PF00644
(PARP) 		5 HIS A 887
GLY A 888
TYR A 919
ALA A 921
TYR A 932
 3AB  A1025 (-3.8A)
3AB  A1025 (-3.5A)
3AB  A1025 (-4.4A)
3AB  A1025 ( 3.9A)
3AB  A1025 (-3.7A)
 0.52A 1dmaB-3hkvA:
5.3		 1dmaB-3hkvA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLY B 930
TYR B 962
ALA B 966
GLU B 968
 None
 0.92A 1dmaB-3hkzB:
undetectable		 1dmaB-3hkzB:
12.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ki6 CHOLIX TOXIN

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly) 		6 HIS A 460
GLY A 461
TYR A 493
ALA A 495
TYR A 504
GLU A 581
 G9L  A   1 (-3.9A)
G9L  A   1 (-3.7A)
G9L  A   1 (-4.5A)
G9L  A   1 (-3.4A)
G9L  A   1 (-3.5A)
G9L  A   1 (-4.6A)
 0.42A 1dmaB-3ki6A:
23.1		 1dmaB-3ki6A:
40.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9j TNFALPHA

(Homo sapiens) 		PF00059
(Lectin_C) 		4 GLY C  90
TYR C  97
ALA C  95
GLU C  98
 None
 0.94A 1dmaB-3l9jC:
undetectable		 1dmaB-3l9jC:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		4 HIS A 217
GLY A   9
ALA A 154
GLU A 158
 None
 1.03A 1dmaB-3lkzA:
undetectable		 1dmaB-3lkzA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		4 GLY A 145
ALA A 229
TYR A 146
GLU A 256
 None
ACT  A 452 ( 4.0A)
None
None
 0.99A 1dmaB-3mznA:
undetectable		 1dmaB-3mznA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz6 LEUCYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00133
(tRNA-synt_1) 		4 HIS A 379
GLY A 389
ALA A 374
GLU A 371
 None
 0.92A 1dmaB-3pz6A:
undetectable		 1dmaB-3pz6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		6 HIS A 460
GLY A 461
TYR A 493
ALA A 495
TYR A 504
GLU A 581
 NAD  A 700 (-3.8A)
NAD  A 700 (-3.7A)
NAD  A 700 ( 3.7A)
NAD  A 700 ( 3.9A)
NAD  A 700 (-3.4A)
NAD  A 700 (-3.2A)
 0.43A 1dmaB-3q9oA:
23.2		 1dmaB-3q9oA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rag UNCHARACTERIZED
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00092
(VWA) 		4 HIS A  32
GLY A  65
ALA A  28
GLU A  26
 None
 1.01A 1dmaB-3ragA:
undetectable		 1dmaB-3ragA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 HIS A 194
GLY A 196
ALA A 139
TYR A 253
 None
 0.95A 1dmaB-3rd5A:
undetectable		 1dmaB-3rd5A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uq3 HEAT SHOCK PROTEIN
STI1

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16) 		4 GLY A 432
ALA A 426
TYR A 433
GLU A 428
 None
 1.01A 1dmaB-3uq3A:
undetectable		 1dmaB-3uq3A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

([Clostridium]
cellulolyticum) 		PF01261
(AP_endonuc_2) 		4 HIS A  66
GLY A  67
ALA A  36
GLU A  15
 None
FUD  A 301 ( 4.2A)
None
None
 1.03A 1dmaB-3vnkA:
undetectable		 1dmaB-3vnkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		4 GLY A 851
TYR A 858
ALA A 856
GLU A 859
 None
 0.93A 1dmaB-3zgbA:
undetectable		 1dmaB-3zgbA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae) 		PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T) 		5 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 None
 0.84A 1dmaB-4ae0A:
8.6		 1dmaB-4ae0A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckk DNA GYRASE SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV) 		4 GLY A 418
TYR A 448
ALA A 384
GLU A 381
 None
 0.97A 1dmaB-4ckkA:
undetectable		 1dmaB-4ckkA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eay MANNONATE
DEHYDRATASE

(Escherichia
coli) 		PF03786
(UxuA) 		4 GLY A   9
ALA A  30
TYR A   8
GLU A  63
 None
None
None
CS2  A 402 (-3.6A)
 0.90A 1dmaB-4eayA:
undetectable		 1dmaB-4eayA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Burkholderia
pseudomallei) 		PF00753
(Lactamase_B) 		4 HIS A 236
GLY A 178
ALA A 180
TYR A 177
 None
 0.84A 1dmaB-4efzA:
undetectable		 1dmaB-4efzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elz DNA GYRASE SUBUNIT A

(Aliivibrio
fischeri) 		PF00521
(DNA_topoisoIV) 		4 GLY A 418
TYR A 448
ALA A 384
GLU A 381
 None
None
None
GOL  A 501 (-3.0A)
 1.01A 1dmaB-4elzA:
undetectable		 1dmaB-4elzA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq5 DNA LIGASE

(Thermococcus
sibiricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLY A 464
TYR A 466
ALA A 551
GLU A 549
 None
 0.97A 1dmaB-4eq5A:
undetectable		 1dmaB-4eq5A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0d POLY [ADP-RIBOSE]
POLYMERASE 16

(Homo sapiens) 		PF00644
(PARP) 		4 HIS A 152
GLY A 153
TYR A 182
TYR A 193
 3AB  A 301 (-4.0A)
3AB  A 301 (-3.4A)
3AB  A 301 (-4.3A)
3AB  A 301 (-3.8A)
 0.47A 1dmaB-4f0dA:
4.8		 1dmaB-4f0dA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0e POLY [ADP-RIBOSE]
POLYMERASE 15

(Homo sapiens) 		PF00644
(PARP) 		5 HIS A 537
GLY A 538
TYR A 569
ALA A 571
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.7A)
 0.43A 1dmaB-4f0eA:
4.9		 1dmaB-4f0eA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h54 DIGUANYLATE CYCLASE
YDEH

(Escherichia
coli) 		PF00990
(GGDEF) 		4 GLY A 267
TYR A 274
ALA A 272
GLU A 275
 None
 0.96A 1dmaB-4h54A:
undetectable		 1dmaB-4h54A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l2k TANKYRASE-2

(Homo sapiens) 		PF00644
(PARP) 		5 HIS A1031
GLY A1032
TYR A1060
ALA A1062
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
1V8  A1201 (-3.3A)
 0.41A 1dmaB-4l2kA:
2.4		 1dmaB-4l2kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oa7 TANKYRASE-1

(Homo sapiens) 		PF00644
(PARP) 		6 HIS A1184
GLY A1185
TYR A1213
ALA A1215
TYR A1224
GLU A1291
 2XS  A1402 (-4.2A)
None
2XS  A1402 (-4.2A)
None
2XS  A1402 ( 3.9A)
None
 0.67A 1dmaB-4oa7A:
5.3		 1dmaB-4oa7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 HIS B 180
TYR B 135
ALA B 133
GLU B 131
 None
None
None
A  C   3 ( 2.7A)
 1.01A 1dmaB-4oavB:
undetectable		 1dmaB-4oavB:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqa POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg)
PF05406
(WGR) 		6 HIS C 862
GLY C 863
TYR C 896
ALA C 898
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.40A 1dmaB-4oqaC:
5.9		 1dmaB-4oqaC:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p48 ANTIBODY SCFV 180

(Gallus gallus) 		PF07686
(V-set) 		4 GLY A  90
TYR A  32
ALA A  92
TYR A  33
 None
 1.03A 1dmaB-4p48A:
undetectable		 1dmaB-4p48A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 HIS A  98
GLY A 186
TYR A 190
ALA A 192
 None
 0.94A 1dmaB-4pfwA:
undetectable		 1dmaB-4pfwA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu6 L-ASPARAGINASE ALPHA
SUBUNIT

(Phaseolus
vulgaris) 		PF01112
(Asparaginase_2) 		4 GLY A  93
ALA A  82
TYR A 119
GLU A  81
 None
 1.03A 1dmaB-4pu6A:
undetectable		 1dmaB-4pu6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py4 POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF00644
(PARP) 		5 HIS A1682
GLY A1683
TYR A1714
ALA A1716
TYR A1727
 XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.4A)
XL2  A1901 (-3.6A)
 0.35A 1dmaB-4py4A:
5.2		 1dmaB-4py4A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rph UDP-GALACTOPYRANOSE
MUTASE

(Mycobacterium
tuberculosis) 		no annotation 5 HIS B  65
GLY B  63
TYR B  48
TYR B  62
GLU B  50
 FAD  B 401 (-3.5A)
FAD  B 401 (-3.5A)
None
None
None
 1.41A 1dmaB-4rphB:
undetectable		 1dmaB-4rphB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)

(Clostridium
acetobutylicum) 		PF07470
(Glyco_hydro_88) 		4 GLY A 349
TYR A 356
ALA A 354
GLU A 357
 None
 1.01A 1dmaB-4wu0A:
undetectable		 1dmaB-4wu0A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgk UDP-GALACTOPYRANOSE
MUTASE

(Corynebacterium
diphtheriae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 HIS A  61
GLY A  59
TYR A  44
TYR A  58
GLU A  46
 FDA  A 403 (-3.7A)
FDA  A 403 ( 3.9A)
None
None
None
 1.41A 1dmaB-4xgkA:
undetectable		 1dmaB-4xgkA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida) 		PF00753
(Lactamase_B) 		4 HIS A 236
GLY A 178
ALA A 180
TYR A 177
 None
None
GSH  A 302 (-3.5A)
None
 0.89A 1dmaB-4yslA:
undetectable		 1dmaB-4yslA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzy POLY [ADP-RIBOSE]
POLYMERASE 2

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg) 		6 HIS A 428
GLY A 429
TYR A 462
ALA A 464
TYR A 473
GLU A 558
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
 0.50A 1dmaB-4zzyA:
4.0		 1dmaB-4zzyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqy HEMAGGLUTININ HA2
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 HIS B  68
GLY B  67
ALA B  65
GLU B  64
 None
 0.97A 1dmaB-5bqyB:
undetectable		 1dmaB-5bqyB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcz TANKYRASE-2

(Homo sapiens) 		PF00644
(PARP) 		5 HIS A1031
GLY A1032
TYR A1060
ALA A1062
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
59B  A1203 (-3.3A)
 0.35A 1dmaB-5dczA:
5.5		 1dmaB-5dczA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcz TANKYRASE-2

(Homo sapiens) 		PF00644
(PARP) 		4 HIS A1031
GLY A1032
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.55A 1dmaB-5dczA:
5.5		 1dmaB-5dczA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsy POLY [ADP-RIBOSE]
POLYMERASE 2

(Homo sapiens) 		PF00644
(PARP) 		6 HIS A 415
GLY A 416
TYR A 449
ALA A 451
TYR A 460
GLU A 545
 UHB  A1001 (-3.7A)
UHB  A1001 (-3.9A)
UHB  A1001 (-3.8A)
UHB  A1001 ( 4.1A)
UHB  A1001 (-3.4A)
UHB  A1001 (-3.5A)
 0.52A 1dmaB-5dsyA:
5.1		 1dmaB-5dsyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 GLY A 494
ALA A 525
TYR A 491
GLU A 545
 None
 0.73A 1dmaB-5e6sA:
undetectable		 1dmaB-5e6sA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 4 HIS A 352
GLY A 354
TYR A  72
ALA A  75
 None
 0.92A 1dmaB-5hssA:
undetectable		 1dmaB-5hssA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 GLY A  87
TYR A  84
ALA A  35
GLU A  30
 None
 0.93A 1dmaB-5infA:
undetectable		 1dmaB-5infA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		4 GLY A1438
ALA A1424
TYR A1439
GLU A1386
 None
None
GLC  A1711 ( 4.4A)
None
 1.03A 1dmaB-5jbeA:
undetectable		 1dmaB-5jbeA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP2

(Rhinovirus C) 		PF00073
(Rhv) 		4 HIS C  99
GLY C 258
TYR C  98
GLU C 261
 None
 0.97A 1dmaB-5k0uC:
undetectable		 1dmaB-5k0uC:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov CAPSID POLYPROTEIN
VP90
PL-2 SCFV CHAIN

(Mamastrovirus
1;
Mus musculus) 		PF12226
(Astro_capsid_p)
PF07686
(V-set) 		4 GLY C1091
TYR C 100
ALA A 458
TYR C1032
 None
 0.96A 1dmaB-5kovC:
undetectable		 1dmaB-5kovC:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2l NAB2P

(Saccharomyces
cerevisiae) 		PF14608
(zf-CCCH_2) 		4 HIS A 430
GLY A 418
TYR A 428
GLU A 413
 ZN  A 501 (-3.3A)
None
A  G   3 ( 3.9A)
ZN  A 504 (-2.6A)
 0.88A 1dmaB-5l2lA:
undetectable		 1dmaB-5l2lA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10

(Homo sapiens) 		PF00644
(PARP) 		5 HIS A 887
GLY A 888
TYR A 919
ALA A 921
TYR A 932
 78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.2A)
78P  A1101 (-3.8A)
 0.64A 1dmaB-5lx6A:
5.3		 1dmaB-5lx6A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swc CARBONIC ANHYDRASE

(Synechocystis
sp. PCC 6803) 		PF00484
(Pro_CA) 		4 GLY A 181
ALA A 152
TYR A 194
GLU A 153
 None
 1.04A 1dmaB-5swcA:
undetectable		 1dmaB-5swcA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpm PYRUVATE
DEHYDROGENASE
COMPLEX REPRESSOR

(Escherichia
coli) 		PF07729
(FCD) 		4 HIS A 222
GLY A 109
ALA A 217
GLU A 215
 None
 0.97A 1dmaB-5tpmA:
undetectable		 1dmaB-5tpmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvk C-PHYCOCYANIN ALPHA
CHAIN

(Thermosynechococcus
elongatus) 		PF00502
(Phycobilisome) 		4 HIS A 140
GLY A 141
ALA A  43
GLU A  39
 None
 0.71A 1dmaB-5uvkA:
undetectable		 1dmaB-5uvkA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 4 HIS A  91
GLY A  90
ALA A  57
GLU A  58
 None
 1.00A 1dmaB-5wgcA:
undetectable		 1dmaB-5wgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 4 HIS A 346
GLY A 360
TYR A  15
ALA A  13
 None
 0.92A 1dmaB-5xb7A:
undetectable		 1dmaB-5xb7A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN
OS02G0668100 PROTEIN

(Oryza sativa;
Oryza sativa) 		PF00348
(polyprenyl_synt)
PF00348
(polyprenyl_synt) 		4 HIS A 124
GLY C 149
ALA C 154
GLU C 192
 None
 1.04A 1dmaB-5xn6A:
undetectable		 1dmaB-5xn6A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xst POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		no annotation 6 HIS A 201
GLY A 202
TYR A 235
ALA A 237
TYR A 246
GLU A 327
 8E6  A 401 (-3.5A)
8E6  A 401 (-3.9A)
8E6  A 401 (-4.1A)
8E6  A 401 (-3.5A)
8E6  A 401 (-3.4A)
8E6  A 401 (-3.9A)
 0.38A 1dmaB-5xstA:
6.1		 1dmaB-5xstA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0m -

(-) 		no annotation 4 GLY A  71
TYR A 156
ALA A 116
TYR A  65
 None
 0.97A 1dmaB-5y0mA:
undetectable		 1dmaB-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 4 GLY A 318
TYR A 313
ALA A 321
GLU A 311
 None
None
None
GOL  A 804 (-3.1A)
 1.01A 1dmaB-5yfbA:
undetectable		 1dmaB-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb4 MOUSE MONOCLONAL
ANTIBODY C5.2 FAB
HEAVY CHAIN
MOUSE MONOCLONAL
ANTIBODY C5.2 FAB
LIGHT CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 HIS L  91
GLY H  96
TYR L  49
GLU L  55
 None
SEP  P 396 ( 3.7A)
None
None
 0.89A 1dmaB-6bb4L:
undetectable		 1dmaB-6bb4L:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhv POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		no annotation 6 HIS A 862
GLY A 863
TYR A 896
ALA A 898
TYR A 907
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
 0.44A 1dmaB-6bhvA:
6.2		 1dmaB-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1

(Mus musculus) 		no annotation 4 HIS A 303
GLY A 301
ALA A 269
GLU A 270
 None
 0.99A 1dmaB-6enzA:
undetectable		 1dmaB-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE

(Legionella
pneumophila) 		no annotation 4 GLY A 315
ALA A 322
TYR A 316
GLU A 326
 None
 1.02A 1dmaB-6eslA:
undetectable		 1dmaB-6eslA:
undetectable